MCID: ASY002
MIFTS: 37

Asymptomatic Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Asymptomatic Neurosyphilis

MalaCards integrated aliases for Asymptomatic Neurosyphilis:

Name: Asymptomatic Neurosyphilis 12 15
Neurosyphilis 44 73
Neurosyphilis, Asymptomatic 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10035
ICD10 33 A52.2
ICD9CM 35 094.3
MeSH 44 D009494
SNOMED-CT 68 37754005
UMLS 73 C0153167

Summaries for Asymptomatic Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in mild meningitis.

MalaCards based summary : Asymptomatic Neurosyphilis, also known as neurosyphilis, is related to neurosyphilis and panuveitis, and has symptoms including syphilitic chancre An important gene associated with Asymptomatic Neurosyphilis is EXTL3 (Exostosin Like Glycosyltransferase 3), and among its related pathways/superpathways are PAK Pathway and NF-kappaB Signaling. Affiliated tissues include skin and heart, and related phenotypes are cellular and hematopoietic system

Wikipedia : 76 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Asymptomatic Neurosyphilis

Diseases related to Asymptomatic Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 neurosyphilis 32.1 CXCL10 CXCL13 IL17A
2 panuveitis 30.1 CD40LG IL17A
3 latent syphilis 28.5 CD40LG DDX41 EXTL3 MYH9
4 syphilis 28.1 CD40LG CD79A DDX41 EXTL3 MYH9
5 syphilitic meningitis 10.8 CD40LG EXTL3
6 optic papillitis 10.8 CD40LG EXTL3
7 pontiac fever 10.7 CD40LG TRIM37
8 early congenital syphilis 10.6 CD40LG MYH9
9 neuroretinitis 10.6 CD40LG EXTL3
10 thrombocytopenia due to platelet alloimmunization 10.6 CD40LG MYH9
11 selective igg deficiency disease 10.6 CD40LG CD79A
12 c1q nephropathy 10.6 CD40LG CD79A
13 meningovascular neurosyphilis 10.6 CD40LG CD79A
14 alpha chain disease 10.6 CD40LG CD79A
15 brill-zinsser disease 10.6 CD40LG CD79A
16 exudative glomerulonephritis 10.6 CD40LG CD79A
17 cork-handlers' disease 10.6 CD40LG CD79A
18 trichomoniasis 10.6 CD79A EXTL3
19 salpingo-oophoritis 10.6 CD40LG CD79A
20 ventilation pneumonitis 10.6 CD40LG CD79A
21 chronic interstitial cystitis 10.6 CD40LG CD79A
22 axillary adenitis 10.6 CD40LG CD79A
23 cryofibrinogenemia 10.6 CD40LG CD79A
24 trichostrongyloidiasis 10.5 CD40LG CD79A
25 subacute bacterial endocarditis 10.5 CD40LG CD79A
26 heterophyiasis 10.5 CD40LG CD79A
27 immunoglobulin g deficiency 10.5 CD40LG CD79A
28 orbital granuloma 10.5 CD40LG CD79A
29 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
30 hyperglobulinemic purpura 10.5 CD40LG CD79A
31 gastroduodenitis 10.5 CD40LG CD79A
32 bacterial conjunctivitis 10.5 CD40LG CD79A
33 heavy chain disease 10.5 CD40LG CD79A
34 ophthalmia neonatorum 10.5 CD40LG CD79A
35 immunoglobulin a deficiency 1 10.5 CD40LG CD79A
36 parotid disease 10.5 CD40LG CD79A
37 cerebral arteritis 10.5 CD40LG CD79A
38 selective immunoglobulin deficiency disease 10.5 CD40LG CD79A
39 geniculate herpes zoster 10.5 CD40LG CD79A
40 rheumatoid lung disease 10.5 CD40LG IL17A
41 erythema elevatum diutinum 10.5 CD40LG CD79A
42 sporotrichosis 10.5 CD40LG CD79A
43 fallopian tube disease 10.5 CD40LG CD79A
44 hyperimmunoglobulin syndrome 10.5 CD40LG CD79A
45 polyclonal hypergammaglobulinemia 10.5 CD40LG CD79A
46 monoclonal paraproteinemia 10.5 CD40LG CD79A
47 salpingitis 10.5 CD40LG CD79A
48 dysgammaglobulinemia 10.5 CD40LG CD79A
49 congenital hypogammaglobulinemia 10.5 CD40LG CD79A
50 acute maxillary sinusitis 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Asymptomatic Neurosyphilis:



Diseases related to Asymptomatic Neurosyphilis

Symptoms & Phenotypes for Asymptomatic Neurosyphilis

UMLS symptoms related to Asymptomatic Neurosyphilis:


syphilitic chancre

MGI Mouse Phenotypes related to Asymptomatic Neurosyphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 EXTL3 GRM1 ITPA CD40LG MYH9 CD79A
2 hematopoietic system MP:0005397 9.86 IL17A ITPA CD40LG MYH9 CD79A TRIM37
3 homeostasis/metabolism MP:0005376 9.76 EXTL3 GRM1 IL17A CD40LG MYH9 CD79A
4 mortality/aging MP:0010768 9.61 DDX41 EXTL3 GRM1 IL17A ITPA CD40LG
5 renal/urinary system MP:0005367 9.02 GRM1 IL17A CD40LG MYH9 CD79A

Drugs & Therapeutics for Asymptomatic Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Asymptomatic Neurosyphilis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: neurosyphilis

Genetic Tests for Asymptomatic Neurosyphilis

Anatomical Context for Asymptomatic Neurosyphilis

MalaCards organs/tissues related to Asymptomatic Neurosyphilis:

41
Skin, Heart

Publications for Asymptomatic Neurosyphilis

Articles related to Asymptomatic Neurosyphilis:

(show all 24)
# Title Authors Year
1
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study. ( 28196838 )
2017
2
Incidence of asymptomatic neurosyphilis in serofast Chinese syphilis patients. ( 29133821 )
2017
3
Value of CXCL13 in diagnosing asymptomatic neurosyphilis in HIV-infected patients. ( 25769888 )
2015
4
Different cerebrospinal fluid levels of Alzheimer-type biomarker AI^42 between general paresis and asymptomatic neurosyphilis. ( 25707998 )
2015
5
Elevated cerebrospinal fluid interleukin-17A and interferon-I^ levels in early asymptomatic neurosyphilis. ( 24275734 )
2013
6
Optimal treatment for asymptomatic neurosyphilis. ( 23104753 )
2012
7
Syphilitic panuveitis and asymptomatic neurosyphilis: a marker of HIV infection. ( 11589818 )
2001
8
Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis. ( 8108759 )
1993
9
Central nervous system involvement in early and late syphilis: the problem of asymptomatic neurosyphilis. ( 3225622 )
1988
10
Ceftriaxone therapy for asymptomatic neurosyphilis. Case report and Western blot analysis of serum and cerebrospinal fluid IgG response to therapy. ( 3764632 )
1986
11
Arthritis in a patient with asymptomatic neurosyphilis. ( 3991433 )
1985
12
Asymptomatic neurosyphilis. ( 6363314 )
1983
13
Penicillin therapy for asymptomatic neurosyphilis: inpatient, intravenous or outpatient, intramuscular? ( 6126763 )
1982
14
Conjugal asymptomatic neurosyphilis. ( 1273776 )
1976
15
Syphilitic stricture of the left main bronchus and early asymptomatic neurosyphilis, presenting with paresis of the left vocal cord. ( 13986399 )
1962
16
Asymptomatic neurosyphilis in Hong Kong. ( 13260624 )
1955
17
Penicillin therapy of asymptomatic neurosyphilis; the spinal fluid cell count as a guide to therapeutic response and re-treatment. ( 14856452 )
1951
18
Gumma of the right side of the face; noduloulcerative syphilis of the arms; asymptomatic neurosyphilis. ( 14782722 )
1950
19
Penicillin therapy in asymptomatic neurosyphilis; a comparison of the effects of amorphous penicillin, penicillin in oil and wax, and crystalline penicillin G. ( 15393649 )
1949
20
Rapid treatment of asymptomatic neurosyphilis. ( 18862297 )
1948
21
The treatment of asymptomatic neurosyphilis in the white mouse. ( 18122297 )
1948
22
Asymptomatic neurosyphilis; prognosis. ( 20277130 )
1946
23
Penicillin in the treatment of neurosyphilis; asymptomatic neurosyphilis. ( 21065217 )
1946
24
Asymptomatic neurosyphilis; a review of the literature. ( 20992346 )
1946

Variations for Asymptomatic Neurosyphilis

Expression for Asymptomatic Neurosyphilis

Search GEO for disease gene expression data for Asymptomatic Neurosyphilis.

Pathways for Asymptomatic Neurosyphilis

Pathways related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 CD40LG CXCL10 CXCL13 IL17A MYH9
2 11.44 CD40LG CD79A CXCL10 IL17A
3 10.82 CD40LG CD79A
4 10.69 CXCL10 CXCL13

GO Terms for Asymptomatic Neurosyphilis

Cellular components related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD40LG CD79A CXCL10 IL17A

Biological processes related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.46 CD40LG CXCL10 CXCL13 IL17A
2 B cell proliferation GO:0042100 9.32 CD40LG CD79A
3 positive regulation of leukocyte chemotaxis GO:0002690 9.26 CXCL10 CXCL13
4 regulation of signaling receptor activity GO:0010469 9.26 CD40LG CXCL10 CXCL13 IL17A
5 inflammatory response GO:0006954 8.92 CD40LG CXCL10 CXCL13 IL17A

Molecular functions related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.26 CD40LG TRIM37
2 CXCR chemokine receptor binding GO:0045236 9.16 CXCL10 CXCL13
3 CXCR3 chemokine receptor binding GO:0048248 8.96 CXCL10 CXCL13
4 cytokine activity GO:0005125 8.92 CD40LG CXCL10 CXCL13 IL17A

Sources for Asymptomatic Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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