MCID: ASY002
MIFTS: 43

Asymptomatic Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Asymptomatic Neurosyphilis

MalaCards integrated aliases for Asymptomatic Neurosyphilis:

Name: Asymptomatic Neurosyphilis 12 15
Neurosyphilis 45 74
Neurosyphilis, Asymptomatic 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10035
ICD9CM 36 094.3
MeSH 45 D009494
SNOMED-CT 69 37754005
ICD10 34 A52.2

Summaries for Asymptomatic Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in mild meningitis.

MalaCards based summary : Asymptomatic Neurosyphilis, also known as neurosyphilis, is related to tabes dorsalis and late congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Asymptomatic Neurosyphilis is EXTL3 (Exostosin Like Glycosyltransferase 3), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and NF-kappaB Signaling. Affiliated tissues include skin, testes and heart, and related phenotypes are cellular and hematopoietic system

Wikipedia : 77 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Asymptomatic Neurosyphilis

Diseases related to Asymptomatic Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 tabes dorsalis 32.8 CXCL13 DDX41 EXTL3
2 late congenital syphilis 32.6 DDX41 EXTL3
3 neurosyphilis 32.2 CXCL10 CXCL13 IL17A
4 tertiary neurosyphilis 31.9 CXCL10 CXCL13 DDX41 EXTL3 GRM1 ITPA
5 tertiary syphilis 30.9 DDX41 EXTL3 MYH9
6 syphilis 30.2 DDX41 EXTL3 MYH9
7 secondary syphilis 30.1 DDX41 EXTL3
8 neuritis 30.0 CXCL10 IFNG
9 latent syphilis 29.7 DDX41 EXTL3 MYH9
10 congenital syphilis 29.6 DDX41 EXTL3 MYH9
11 polyradiculoneuropathy 29.5 IFNG IL17A
12 meningovascular neurosyphilis 12.5
13 parenchymatous neurosyphilis 12.5
14 argyll robertson pupil 11.4
15 syphilitic aseptic meningitis 11.1
16 aids - neurological complications 11.1
17 cerebral atrophy 11.1
18 dementia 10.5
19 malaria 10.5
20 encephalitis 10.4
21 status epilepticus 10.4
22 trichomoniasis 10.2 EXTL3 IRF6
23 human immunodeficiency virus type 1 10.2
24 limbic encephalitis 10.2
25 peanut allergy 10.1 CXCL10 IFNG
26 acute graft versus host disease 10.1 IFNG MYH9
27 schizophrenia 10.1
28 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.1
29 hepatitis 10.1
30 herpes simplex 10.1
31 herpes simplex encephalitis 10.1
32 syphilitic myelopathy 10.1
33 viral meningitis 10.1 CXCL10 IFNG
34 spotted fever 10.0 CXCL10 IFNG
35 primary peritoneal carcinoma 10.0 CXCL10 IFNG
36 proliferative glomerulonephritis 10.0 CXCL10 IFNG
37 invasive aspergillosis 10.0 CXCL10 IFNG
38 alzheimer disease 10.0
39 optic neuritis 10.0
40 neuropathy 10.0
41 chorioretinitis 10.0
42 meningitis 10.0
43 eumycotic mycetoma 10.0 DDX41 IFNG
44 paracoccidioidomycosis 10.0 CXCL10 IFNG
45 autoimmune disease of endocrine system 10.0 DDX41 IFNG
46 thrombocytopenia due to platelet alloimmunization 10.0 IL17A MYH9
47 primary syphilis 9.9 DDX41 EXTL3 MYH9
48 creutzfeldt-jakob disease 9.9
49 3-methylglutaconic aciduria, type iii 9.9
50 stroke, ischemic 9.9

Graphical network of the top 20 diseases related to Asymptomatic Neurosyphilis:



Diseases related to Asymptomatic Neurosyphilis

Symptoms & Phenotypes for Asymptomatic Neurosyphilis

UMLS symptoms related to Asymptomatic Neurosyphilis:


syphilitic chancre

MGI Mouse Phenotypes related to Asymptomatic Neurosyphilis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.81 CXCL10 CXCL13 EXTL3 GRM1 IFNG IRF6
2 hematopoietic system MP:0005397 9.5 CXCL10 CXCL13 IFNG IL17A ITPA MYH9
3 mortality/aging MP:0010768 9.32 CXCL10 DDX41 EXTL3 GRM1 IFNG IL17A

Drugs & Therapeutics for Asymptomatic Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Asymptomatic Neurosyphilis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: neurosyphilis

Genetic Tests for Asymptomatic Neurosyphilis

Anatomical Context for Asymptomatic Neurosyphilis

MalaCards organs/tissues related to Asymptomatic Neurosyphilis:

42
Skin, Testes, Heart, Brain, T Cells, Spinal Cord, B Cells

Publications for Asymptomatic Neurosyphilis

Articles related to Asymptomatic Neurosyphilis:

(show top 50) (show all 979)
# Title Authors Year
1
Neurosyphilis presenting as cranial nerve palsy, an entity which is easy to miss. ( 30796075 )
2019
2
A Rare Case of Neurosyphilis with Ocular Involvement in a Patient with HIV Infection and New Onset Syphilis. ( 31011497 )
2019
3
Schizophrenia-like psychosis as the presenting feature of neurosyphilis in a non-human immunodeficiency virus-infected Indian man: A reminder of a forgotten complication! ( 30992619 )
2019
4
Exosomal microRNA profiles from serum and cerebrospinal fluid in neurosyphilis. ( 30926713 )
2019
5
Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis. ( 30912484 )
2019
6
Metabolite Profiles of the Cerebrospinal Fluid in Neurosyphilis Patients Determined by Untargeted Metabolomics Analysis. ( 30863278 )
2019
7
Changes of T lymphocyte subsets in patients with HIV-negative symptomatic neurosyphilis. ( 30862559 )
2019
8
Neurosyphilis: Concordance between cerebrospinal fluid analysis and subsequent antibiotic strategy for patients undergoing evaluation of a diagnosis of neurosyphilis. ( 30853444 )
2019
9
A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies. ( 30810592 )
2019
10
Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review. ( 30586032 )
2019
11
Early neurosyphilis presenting with multiple cranial nerve palsies: A case report of management by combined penicillin-corticosteroid treatment. ( 30538059 )
2019
12
Risk of neurosyphilis in HIV-infected persons with syphilis lacking signs or symptoms of central nervous system infection. ( 30402918 )
2019
13
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. ( 30368740 )
2019
14
Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period. ( 30923165 )
2019
15
Neurosyphilis presenting as rapidly progressive psychosis & dementia - A forgotten entity. ( 30785032 )
2019
16
A Case Report of Neurosyphilis Limbic Encephalitis With Reversible Geschwind Syndrome and Mood Disorder. ( 31083037 )
2019
17
Lesson of the month 1: Neurosyphilis mimicking viral encephalitis and ischaemic stroke. ( 31092522 )
2019
18
Atypical development of neurosyphilis mimicking limbic encephalitis. ( 30253732 )
2019
19
Neurosyphilis Presenting with Anxiety: A Case Report. ( 30254809 )
2018
20
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study. ( 28196838 )
2018
21
Newly diagnosed AIDS with neurosyphilis, Kaposi sarcoma, pancytopenia, oropharyngeal candidiasis, and pseudomonal pneumonia: We shouldn't be seeing this anymore. ( 30101071 )
2018
22
How Well Do Neurologic Symptoms Identify Individuals With Neurosyphilis? ( 29020214 )
2018
23
Biological false-positive venereal disease research laboratory test in cerebrospinal fluid in the diagnosis of neurosyphilis - a case-control study. ( 29117430 )
2018
24
Historical reflections on neurosyphilis based on the 1826 treatise on general paralysis in demented patients by Louis Florentin Calmeil (1798-1895). ( 29169563 )
2018
25
Diverse clinical presentations of neurosyphilis: focus on differential diagnosis. ( 29181654 )
2018
26
Diversity in clinical manifestations and imaging features of neurosyphilis: obstacles to the diagnosis and treatment (report of three cases). ( 29199527 )
2018
27
Diplopia: An Overlooked Feature in Patients With Neurosyphilis. Report of 2 Cases and Literature Review. ( 29329180 )
2018
28
Management of neurosyphilis: time for a new approach? ( 29415349 )
2018
29
Neurosyphilis: Knowledge Gaps and Controversies. ( 29420441 )
2018
30
A case of very early neurosyphilis presented as schizophrenia-like psychosis. ( 29453149 )
2018
31
Neurosyphilis in patients with HIV. ( 29478035 )
2018
32
The clinical and laboratory features of neurosyphilis in HIV-infected patients: A retrospective study in 92 patients. ( 29489672 )
2018
33
Teaching NeuroImages: Gummatous neurosyphilis: An atypical presentation in a patient with HIV. ( 29507143 )
2018
34
Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report. ( 29545440 )
2018
35
Postmortem Histopathologic Analysis of Neurosyphilis: A Report of 3 Cases With Clinicopathologic Correlations. ( 29546365 )
2018
36
Neurosyphilis with Bilateral Optic Perineuritis in an Immunocompetent Patient. ( 29566376 )
2018
37
The performance of rapid plasma reagin (RPR) titer in HIV-negative general paresis after neurosyphilis therapy. ( 29606102 )
2018
38
Electroclinical and radiological observation of dysfunctional zones in a patient with neurosyphilis. ( 29620006 )
2018
39
Different Faces of Neurosyphilis. ( 29624563 )
2018
40
Ischemic Stroke in an HIV Positive Patient: An Initial Presentation of Neurosyphilis. ( 29666731 )
2018
41
Pruritic plaque on the arm after treatment for neurosyphilis. ( 30576631 )
2018
42
Neurosyphilis and classical music: the great composers and "The Great Imitator". ( 30570024 )
2018
43
Neurosyphilis: a masked evildoer. ( 30530406 )
2018
44
Lack of antiretroviral therapy is associated with higher risk of neurosyphilis among HIV-infected patients who remain serofast after therapy for early syphilis. ( 30407349 )
2018
45
Neurosyphilis concurrently involving eye and ear. ( 30344157 )
2018
46
Neurosyphilis prevalence at a Portuguese stroke unit care. ( 30343380 )
2018
47
Neuroborreliosis and Neurosyphilis. ( 30273247 )
2018
48
Neurosyphilis: A Simulation Case for Emergency Medicine Residents. ( 30237945 )
2018
49
Medial medullary stroke due to neurosyphilis in a newly diagnosed HIV-positive man. ( 30133989 )
2018
50
Charcot osteoarthropathy of the knee secondary to neurosyphilis: a rare condition managed by a challenging arthrodesis. ( 30131415 )
2018

Variations for Asymptomatic Neurosyphilis

Expression for Asymptomatic Neurosyphilis

Search GEO for disease gene expression data for Asymptomatic Neurosyphilis.

Pathways for Asymptomatic Neurosyphilis

GO Terms for Asymptomatic Neurosyphilis

Biological processes related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.61 CXCL10 CXCL13 IFNG
2 cell-cell signaling GO:0007267 9.58 CXCL10 CXCL13 IL17A
3 immune response GO:0006955 9.56 CXCL10 CXCL13 IFNG IL17A
4 defense response to virus GO:0051607 9.54 CXCL10 DDX41 IFNG
5 leukocyte chemotaxis GO:0030595 9.32 CXCL10 CXCL13
6 regulation of signaling receptor activity GO:0010469 9.26 CXCL10 CXCL13 IFNG IL17A
7 positive regulation of osteoclast differentiation GO:0045672 9.16 IFNG IL17A
8 positive regulation of interleukin-23 production GO:0032747 8.62 IFNG IL17A

Molecular functions related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CXCL10 CXCL13
2 CXCR3 chemokine receptor binding GO:0048248 8.96 CXCL10 CXCL13
3 cytokine activity GO:0005125 8.92 CXCL10 CXCL13 IFNG IL17A

Sources for Asymptomatic Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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