MCID: ASY002
MIFTS: 41

Asymptomatic Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Asymptomatic Neurosyphilis

MalaCards integrated aliases for Asymptomatic Neurosyphilis:

Name: Asymptomatic Neurosyphilis 12 15 32
Neurosyphilis 44 70
Neurosyphilis, Asymptomatic 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10035
ICD9CM 34 094.3
MeSH 44 D009494
SNOMED-CT 67 37754005
ICD10 32 A52.2
UMLS 70 C0027927 C0153167

Summaries for Asymptomatic Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in mild meningitis.

MalaCards based summary : Asymptomatic Neurosyphilis, also known as neurosyphilis, is related to tabes dorsalis and meningovascular neurosyphilis, and has symptoms including syphilitic chancre An important gene associated with Asymptomatic Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Ceftriaxone and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, eye and skin.

Wikipedia : 73 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Asymptomatic Neurosyphilis

Diseases related to Asymptomatic Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 357)
# Related Disease Score Top Affiliating Genes
1 tabes dorsalis 32.5 CXCL13 CD4
2 meningovascular neurosyphilis 31.8 IL17A CXCL13 CD4
3 neurosyphilis 31.6 IL17A CXCL13 CXCL10
4 tertiary neurosyphilis 31.6 ITPA CXCL13 CD4 CCL15
5 secondary syphilis 31.0 CXCL13 CD4
6 syphilitic meningitis 31.0 CXCL13 CD4
7 syphilis 30.7 IL17A CD4
8 primary syphilis 30.7 CD4 CCL15
9 latent syphilis 30.6 CXCL13 CD4
10 tertiary syphilis 30.2 CXCL13 CD4
11 meningoencephalitis 30.2 CXCL10 CD4
12 viral encephalitis 30.2 CXCL10 CD4
13 chorioretinitis 30.1 IL17A CD4
14 aortitis 29.9 IL17A CD4
15 panuveitis 29.7 IL17A CD4
16 tick-borne encephalitis 29.7 CXCL13 CXCL10
17 sarcoidosis 1 29.6 CXCL5 CXCL10 CD4
18 iritis 29.5 IL17A CD4
19 iridocyclitis 29.5 IL17A CD4
20 central nervous system vasculitis 29.5 IL17A CD4
21 neuromyelitis optica 29.4 IL17A CXCL13 CXCL10
22 spinal cord disease 29.1 IL17A CXCL10 CD4
23 leprosy 3 29.1 IL17A CXCL10 CD4
24 demyelinating disease 29.1 IL17A CXCL10 CD4
25 pneumonia 29.1 IL17A CXCL5 CXCL10
26 multiple sclerosis 28.8 IL17A CXCL13 CXCL10 CD4
27 peripheral nervous system disease 28.5 NEFH IL17A CD4
28 parenchymatous neurosyphilis 11.3
29 late congenital syphilis 11.1
30 cerebral atrophy 11.0
31 argyll robertson pupil 11.0
32 aids - neurological complications 10.9
33 transient pseudohypoaldosteronism 10.5
34 encephalitis 10.4
35 immune deficiency disease 10.3
36 status epilepticus 10.3
37 malaria 10.3
38 dementia 10.3
39 polyclonal hypergammaglobulinemia 10.3 CXCL13 CD4
40 facial nerve disease 10.3 CXCL13 CD4
41 west nile encephalitis 10.3 ITPA CD4
42 postinfectious encephalitis 10.3 CXCL13 CCL15
43 ataxia and polyneuropathy, adult-onset 10.2
44 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
45 acquired immunodeficiency syndrome 10.2
46 multicentric castleman disease 10.2 CXCL13 CD4
47 castleman disease 10.2 CXCL13 CD4
48 central nervous system hematologic cancer 10.2 CXCL13 CD4
49 disease by infectious agent 10.2
50 noonan syndrome 4 10.2 ITPA CD4

Graphical network of the top 20 diseases related to Asymptomatic Neurosyphilis:



Diseases related to Asymptomatic Neurosyphilis

Symptoms & Phenotypes for Asymptomatic Neurosyphilis

UMLS symptoms related to Asymptomatic Neurosyphilis:


syphilitic chancre

Drugs & Therapeutics for Asymptomatic Neurosyphilis

Drugs for Asymptomatic Neurosyphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved 73384-59-5 5479530 5361919
2
Penicillin G Approved, Vet_approved 61-33-6 5904
3
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
4 Anti-Bacterial Agents
5 penicillins
6 Penicillin G Procaine
7 Anti-Infective Agents
8 Penicillin G Benzathine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
2 Xijing HOSPITAL, Fourth Military Medical University, China Completed NCT00921648
3 A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals Completed NCT00000648 Penicillin G potassium;Ceftriaxone sodium
4 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441

Search NIH Clinical Center for Asymptomatic Neurosyphilis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Probenecid

Cochrane evidence based reviews: neurosyphilis

Genetic Tests for Asymptomatic Neurosyphilis

Anatomical Context for Asymptomatic Neurosyphilis

MalaCards organs/tissues related to Asymptomatic Neurosyphilis:

40
Spinal Cord, Eye, Skin, Kidney, Cerebellum, T Cells, Lymph Node

Publications for Asymptomatic Neurosyphilis

Articles related to Asymptomatic Neurosyphilis:

(show top 50) (show all 2257)
# Title Authors PMID Year
1
Cerebrospinal Fluid Analysis. 61
33788511 2021
2
A Failure of Rapid Drug Desensitization. 61
33748854 2021
3
Clinical and serological outcomes in patients treated with oral doxycycline for early neurosyphilis. 61
33783506 2021
4
Identification of the factors associated with post-treatment asymptomatic neurosyphilis in HIV-negative patients with serological non-response syphilis: a retrospective study. 61
33345747 2021
5
Neurosyphilis and the Jarisch-Herxheimer reaction: A therapy concern with HIV disease. 61
33527658 2021
6
Neurosyphilis and Lyme neuroborreliosis. 61
33709978 2021
7
Combination of the neutrophil to lymphocyte ratio and serum toluidine red unheated serum test titer as a predictor of neurosyphilis in HIV-negative patients. 61
33488794 2021
8
Incidental finding of neurosyphilis with intracranial hemorrhage and cerebral infarction: A case report. 61
33067106 2021
9
Cerebrospinal fluid findings in patients with psychotic symptoms-a retrospective analysis. 61
33785807 2021
10
Prevalence of Self-reported Neurologic and Ocular Symptoms in Early Syphilis Cases. 61
32103243 2021
11
Concurrent benign tertiary syphilis and asymptomatic neurosyphilis in an immunocompetent patient. 61
32810327 2021
12
Imaging Characteristics of Brain SPECT, PET, and MRI in Neurosyphilis. 61
33643490 2021
13
An Unusual Case of Neurosyphilis Manifesting as Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH). 61
33589580 2021
14
Small vessel occlusion and syphilis in patients with first-ever ischemic stroke. 61
33759975 2021
15
The relationship of syphilis to small vessel stroke in the absence of neurosyphilis: real or imaginary? 61
33759974 2021
16
All that glitters is not gold: A limbic encephalitis due to neurosyphilis. 61
32631679 2021
17
Syfilis med dobbeltsyn. 61
33433108 2021
18
Syphilis with vision loss. 61
33433102 2021
19
Assessing Utilization of the Cerebrospinal Fluid Venereal Disease Research Laboratory Test for Diagnosis of Neurosyphilis: a Cohort Study. 61
32869202 2021
20
Diagnostic role of CXCL13 and CSF serology in patients with neurosyphilis. 61
33436504 2021
21
Neurosyphilis Masquerading as Guillain-Barre Syndrome. 61
33449490 2021
22
Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis. 61
31647700 2021
23
Clinical and laboratory characteristics of ocular syphilis and neurosyphilis among individuals with and without HIV infection. 61
32220852 2021
24
[Brazilian Protocol for Sexually Transmitted Infections 2020: acquired syphilis]. 61
33729409 2021
25
Prolonged postictal hemianopsia after a focal extraoccipital onset seizure. 61
33431543 2021
26
Outcomes of infants born to pregnant women with syphilis: a nationwide study in Korea. 61
33478429 2021
27
[Brazilian Protocol for Sexually Transmitted Infections 2020: syphilis diagnostic tests]. 61
33729411 2021
28
Clinical Manifestations, Fluid Changes and Neuroimaging Alterations in Patients with General Paresis of the Insane. 61
33469294 2021
29
Prevalence of syphilis, neurosyphilis and associated factors in a cross-sectional analysis of HIV infected patients attending Bugando Medical Centre, Mwanza, Tanzania. 61
33276749 2020
30
Identification of an HIV-1 and Neurosyphilis Cluster in Vermont. 61
33289032 2020
31
An Atypical Case of Neurosyphilis. 61
33271641 2020
32
Asymptomatic neurosyphilis may need early intervention in people living with HIV. 61
33273339 2020
33
Appearance of Meningovascular Neurosyphilis Causing an Acute Ischemic Stroke. 61
33165212 2020
34
Decomplexifying Serum and Cerebrospinal Fluid (CSF) Serologic Testing of Neurosyphilis: A Case Report of Ocular Syphilis and Highlights of the Principles of Serologic Testing. 61
33354477 2020
35
Deciphering the serological response to syphilis treatment in men living with HIV. 61
32773482 2020
36
Ocular syphilis 61
33161392 2020
37
Clinical and ophthalmologic characteristics of ocular syphilis in a retrospective tertiary hospital cohort. 61
33156290 2020
38
Neurosyphilis in AIDS patient presenting as isolated cranial nerve 6 palsy. 61
33088510 2020
39
Hearing loss in individuals at risk for neurosyphilis. 61
32928054 2020
40
A Rare Cause of Acute Bilateral Hearing Loss: Otosyphilis. 61
33274126 2020
41
Outcomes from re-treatment and cerebrospinal fluid analyses in syphilis patients who had serological non-response or lack of seroreversion after initial therapy. 61
33093287 2020
42
Early symptomatic neurosyphilis and ocular syphilis: A comparative study between HIV-positive and HIV-negative patients. 61
33239175 2020
43
Immunoblot and Polymerase Chain Reaction to Diagnose Ocular Syphilis and Neurosyphilis in HIV-positive and HIV-negative Patients. 61
31944129 2020
44
A new specimen for syphilis diagnosis: Evidence by high loads of Treponema pallidum DNA in saliva. 61
33099614 2020
45
Recurrent ocular syphilis in a patient living with HIV. 61
32829675 2020
46
Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals. 61
32657637 2020
47
Choriocapillaris Involvement in Acute Syphilis Posterior Placoid Chorioretinitis is Responsible for Functional Impairment and Points towards an Immunologic Mechanism: A Comprehensive Clinicopathological Approach. 61
33553841 2020
48
Increased CCL24 and CXCL7 levels in the cerebrospinal fluid of patients with neurosyphilis. 61
32419252 2020
49
False positives in the ultrasound diagnosis of giant cell arteritis: some diseases can also show the halo sign. 61
31953951 2020
50
Cerebral thrombophlebitis and neurosyphilis: Association or coincidence. 61
32631676 2020

Variations for Asymptomatic Neurosyphilis

Expression for Asymptomatic Neurosyphilis

Search GEO for disease gene expression data for Asymptomatic Neurosyphilis.

Pathways for Asymptomatic Neurosyphilis

Pathways related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 IL17A CXCL5 CXCL13 CXCL10 CD4 CCL15
2
Show member pathways
13.19 IL17A CXCL5 CXCL13 CXCL10 CD4 CCL15
3
Show member pathways
12.95 IL17A CXCL5 CXCL13 CXCL10 CD4 CCL15
4
Show member pathways
12.7 IL17A CXCL5 CXCL13 CXCL10 CD4 CCL15
5
Show member pathways
12.41 CXCL5 CXCL13 CXCL10 CD4 CCL15
6
Show member pathways
11.94 IL17A CXCL5 CXCL10
7
Show member pathways
11.59 CXCL5 CXCL13 CXCL10 CCL15
8 10.99 CXCL13 CXCL10
9 9.92 IL17A CXCL5 CXCL13 CXCL10 CCL15

GO Terms for Asymptomatic Neurosyphilis

Cellular components related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 PILRA IL17A CXCL5 CXCL13 CXCL10 CCL15

Biological processes related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.95 PILRA CXCL5 CXCL13 CXCL10 CD4 CCL15
2 cell surface receptor signaling pathway GO:0007166 9.72 CD4 CXCL10 CXCL13
3 inflammatory response GO:0006954 9.72 IL17A CXCL5 CXCL13 CXCL10 CCL15
4 cytokine-mediated signaling pathway GO:0019221 9.71 CD4 CXCL10 IL17A
5 cellular response to lipopolysaccharide GO:0071222 9.69 CXCL5 CXCL13 CXCL10
6 defense response GO:0006952 9.67 CXCL5 CXCL13 CXCL10
7 chemotaxis GO:0006935 9.67 CXCL5 CXCL13 CXCL10 CCL15
8 cell chemotaxis GO:0060326 9.61 CXCL5 CXCL13 CCL15
9 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.58 CXCL5 CXCL13 CXCL10
10 neutrophil chemotaxis GO:0030593 9.56 CXCL5 CXCL13 CXCL10 CCL15
11 positive chemotaxis GO:0050918 9.52 CCL15 CXCL10
12 response to vitamin D GO:0033280 9.46 CXCL10 CD4
13 chemokine-mediated signaling pathway GO:0070098 9.46 CXCL5 CXCL13 CXCL10 CCL15
14 cell-cell signaling GO:0007267 9.35 IL17A CXCL5 CXCL13 CXCL10 CCL15
15 immune response GO:0006955 9.1 IL17A CXCL5 CXCL13 CXCL10 CD4 CCL15

Molecular functions related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.5 CXCL13 CXCL10 CCL15
2 chemoattractant activity GO:0042056 9.37 CXCL10 CCL15
3 cytokine activity GO:0005125 9.35 IL17A CXCL5 CXCL13 CXCL10 CCL15
4 CXCR chemokine receptor binding GO:0045236 9.33 CXCL5 CXCL13 CXCL10
5 CXCR3 chemokine receptor binding GO:0048248 9.26 CXCL13 CXCL10
6 chemokine activity GO:0008009 8.92 CXCL5 CXCL13 CXCL10 CCL15

Sources for Asymptomatic Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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