MCID: ASY002
MIFTS: 44

Asymptomatic Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Asymptomatic Neurosyphilis

MalaCards integrated aliases for Asymptomatic Neurosyphilis:

Name: Asymptomatic Neurosyphilis 12 15
Neurosyphilis 44 73
Neurosyphilis, Asymptomatic 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10035
ICD10 33 A52.2
ICD9CM 35 094.3
MeSH 44 D009494
SNOMED-CT 68 37754005

Summaries for Asymptomatic Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in mild meningitis.

MalaCards based summary : Asymptomatic Neurosyphilis, also known as neurosyphilis, is related to tabes dorsalis and tertiary neurosyphilis, and has symptoms including syphilitic chancre An important gene associated with Asymptomatic Neurosyphilis is EXTL3 (Exostosin Like Glycosyltransferase 3), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include skin, heart and testes, and related phenotypes are cellular and hematopoietic system

Wikipedia : 76 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Asymptomatic Neurosyphilis

Diseases related to Asymptomatic Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 tabes dorsalis 32.9 EXTL3 DDX41 CXCL13
2 tertiary neurosyphilis 32.6 TRIM37 MYH9 ITPA GRM1 EXTL3 DDX41
3 late congenital syphilis 32.6 EXTL3 DDX41
4 neurosyphilis 32.2 IL17A CXCL8 CXCL13 CXCL10
5 tertiary syphilis 30.9 MYH9 EXTL3 DDX41
6 syphilis 30.3 MYH9 EXTL3 DDX41
7 viral infectious disease 30.1 IFNG CXCL8 CXCL10
8 secondary syphilis 30.0 EXTL3 DDX41
9 malaria 29.9 IL17A IFNG CXCL8 CXCL10
10 transverse myelitis 29.8 IL17A CXCL8
11 latent syphilis 29.8 MYH9 EXTL3 DDX41
12 congenital syphilis 29.6 MYH9 EXTL3 DDX41
13 polyradiculoneuropathy 29.4 IL17A IFNG
14 arthritis 29.2 CXCL8 IFNG IL17A
15 multiple sclerosis 29.1 IL17A IFNG CXCL13 CXCL10
16 psoriasis 28.9 IL17A IFNG CXCL8 CXCL10
17 meningovascular neurosyphilis 12.4
18 parenchymatous neurosyphilis 12.4
19 argyll robertson pupil 11.4
20 syphilitic aseptic meningitis 11.0
21 aids - neurological complications 11.0
22 cerebral atrophy 11.0
23 dementia 10.4
24 encephalitis 10.4
25 status epilepticus 10.3
26 trichomoniasis 10.1 EXTL3 CXCL8
27 vaginal disease 10.1 EXTL3 CXCL8
28 limbic encephalitis 10.1
29 thrombocytopenia due to platelet alloimmunization 10.1 MYH9 IL17A
30 glaucomatocyclitic crisis 10.1 CXCL8 CXCL10
31 acute pyelonephritis 10.0 CXCL8 CXCL10
32 fasciitis 10.0 CXCL8 MYH9
33 acute generalized exanthematous pustulosis 10.0 IL17A CXCL8
34 neuritis 10.0
35 herpes simplex 10.0
36 herpes simplex encephalitis 10.0
37 syphilitic myelopathy 10.0
38 stromal keratitis 10.0 IL17A CXCL10
39 primary syphilis 10.0 MYH9 EXTL3 DDX41
40 radiculopathy 10.0 IL17A CXCL8
41 fungal meningitis 10.0 IFNG CXCL10
42 alzheimer disease 10.0
43 schizophrenia 10.0
44 human immunodeficiency virus type 1 10.0
45 hepatitis 10.0
46 optic neuritis 10.0
47 neuropathy 10.0
48 chorioretinitis 10.0
49 meningitis 10.0
50 peanut allergy 10.0 IFNG CXCL10

Graphical network of the top 20 diseases related to Asymptomatic Neurosyphilis:



Diseases related to Asymptomatic Neurosyphilis

Symptoms & Phenotypes for Asymptomatic Neurosyphilis

UMLS symptoms related to Asymptomatic Neurosyphilis:


syphilitic chancre

MGI Mouse Phenotypes related to Asymptomatic Neurosyphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 CXCL10 CXCL13 EXTL3 GRM1 IFNG ITPA
2 hematopoietic system MP:0005397 9.5 CXCL10 CXCL13 IFNG IL17A ITPA MYH9
3 mortality/aging MP:0010768 9.28 CXCL10 DDX41 EXTL3 GRM1 IFNG IL17A

Drugs & Therapeutics for Asymptomatic Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Asymptomatic Neurosyphilis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: neurosyphilis

Genetic Tests for Asymptomatic Neurosyphilis

Anatomical Context for Asymptomatic Neurosyphilis

MalaCards organs/tissues related to Asymptomatic Neurosyphilis:

41
Skin, Heart, Testes, B Cells, Lung, Bone, Tonsil

Publications for Asymptomatic Neurosyphilis

Articles related to Asymptomatic Neurosyphilis:

(show top 50) (show all 358)
# Title Authors Year
1
Neurosyphilis Presenting with Anxiety: A Case Report. ( 30254809 )
2018
2
Newly diagnosed AIDS with neurosyphilis, Kaposi sarcoma, pancytopenia, oropharyngeal candidiasis, and pseudomonal pneumonia: We shouldn't be seeing this anymore. ( 30101071 )
2018
3
Comparison of Clinical and Laboratory Characteristics of General Paresis and Non-Neurosyphilis Dementia. ( 30343296 )
2018
4
Atypical development of neurosyphilis mimicking limbic encephalitis. ( 30253732 )
2018
5
Thomas Mann's depiction of neurosyphilis and other diseases. ( 28471291 )
2018
6
A case of very early neurosyphilis presented as schizophrenia-like psychosis. ( 29453149 )
2018
7
Postmortem Histopathologic Analysis of Neurosyphilis: A Report of 3 Cases With Clinicopathologic Correlations. ( 29546365 )
2018
8
Diagnostic performance of PCR assays for the diagnosis of neurosyphilis: a systematic review. ( 30061192 )
2018
9
Neurosyphilis: The shape of a rising threat. ( 30081207 )
2018
10
Charcot osteoarthropathy of the knee secondary to neurosyphilis: a rare condition managed by a challenging arthrodesis. ( 30131415 )
2018
11
Medial medullary stroke due to neurosyphilis in a newly diagnosed HIV-positive man. ( 30133989 )
2018
12
Neurosyphilis: A Simulation Case for Emergency Medicine Residents. ( 30237945 )
2018
13
Neuroborreliosis and Neurosyphilis. ( 30273247 )
2018
14
Neurosyphilis prevalence at a Portuguese stroke unit care. ( 30343380 )
2018
15
Neurosyphilis concurrently involving eye and ear. ( 30344157 )
2018
16
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. ( 30368740 )
2018
17
Risk of neurosyphilis in HIV-infected persons with syphilis lacking signs or symptoms of central nervous system infection. ( 30402918 )
2018
18
Lack of antiretroviral therapy is associated with higher risk of neurosyphilis among HIV-infected patients who remain serofast after therapy for early syphilis. ( 30407349 )
2018
19
Neurosyphilis: a masked evildoer. ( 30530406 )
2018
20
Early neurosyphilis presenting with multiple cranial nerve palsies: A case report of management by combined penicillin-corticosteroid treatment. ( 30538059 )
2018
21
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study. ( 28196838 )
2017
22
Incidence of asymptomatic neurosyphilis in serofast Chinese syphilis patients. ( 29133821 )
2017
23
Syphilitic chancre and condylomata lata possibly coexisting with neurosyphilis. ( 28093716 )
2017
24
Teaching Video NeuroImages: Candy sign: The clue to the diagnosis of neurosyphilis. ( 28115606 )
2017
25
Repeated episodes of acute stroke as manifestation of neurosyphilis in a well-controlled human immunodeficiency virus-infected patient-Successful treatment with ceftriaxone. ( 28190667 )
2017
26
A Brief Resolved Unexplained Event and Congenital Neurosyphilis. ( 28192580 )
2017
27
The big imitator strikes again: a case report of neurosyphilis in a patient with newly diagnosed HIV. ( 28220718 )
2017
28
Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter? ( 28288165 )
2017
29
A case of neurosyphilis presenting with essential-like tremor. ( 28320518 )
2017
30
Cerebrospinal Fluid Treponema pallidum Particle Agglutination Assay for Neurosyphilis Diagnosis. ( 28381602 )
2017
31
A Case of Early Neurosyphilis. ( 28414665 )
2017
32
Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study. ( 28446129 )
2017
33
Erratum to: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study. ( 28532388 )
2017
34
Neurosyphilis - the white matter disintegration? - two case reports. ( 28953791 )
2017
35
Spinal Intramedullary Syphilitic Gumma: An Unusual Presentation of Neurosyphilis. ( 27452967 )
2016
36
Clinical and Biological Characteristics of 40 Patients With Neurosyphilis and Evaluation of Treponema pallidum Nested Polymerase Chain Reaction in Cerebrospinal Fluid Samples. ( 27585981 )
2016
37
Value of CXCL13 in diagnosing asymptomatic neurosyphilis in HIV-infected patients. ( 25769888 )
2015
38
Different cerebrospinal fluid levels of Alzheimer-type biomarker AI^42 between general paresis and asymptomatic neurosyphilis. ( 25707998 )
2015
39
A clinical study of new cases of parenchymal neurosyphilis: has tabes dorsalis disappeared or been missed? ( 25321411 )
2015
40
The effect of penicillin therapy on cognitive outcomes in neurosyphilis: a systematic review of the literature. ( 25468254 )
2015
41
Neurosyphilis initially presenting as hemorrhagic exudative optic neuropathy in an immunocompetent patient. ( 25970315 )
2015
42
Neurosyphilis: An Uncommon Cause of Dementia. ( 26289700 )
2015
43
Syphilis associated with paretic neurosyphilis mimicking Reiter's syndrome in HIV-infected patients. ( 26312720 )
2015
44
Neurosyphilis presenting as parkinsonism. ( 26416774 )
2015
45
Neurosyphilis: a case report. ( 28058343 )
2015
46
Tabetic arthropathy revealing neurosyphilis: a new observation. ( 25419325 )
2014
47
Neurosyphilis presenting as primary progressive aphasia. ( 24515700 )
2014
48
A case of neurosyphilis presenting with dementia and psychiatric symptoms. ( 24515707 )
2014
49
Solitary cavernous sinus neurosarcoidosis mimicking neurosyphilis. ( 24570823 )
2014
50
Psychosis in neurosyphilis: an association of poor prognosis. ( 24630893 )
2014

Variations for Asymptomatic Neurosyphilis

Expression for Asymptomatic Neurosyphilis

Search GEO for disease gene expression data for Asymptomatic Neurosyphilis.

Pathways for Asymptomatic Neurosyphilis

Pathways related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CXCL10 CXCL13 CXCL8 IL17A MYH9
2
Show member pathways
12.58 CXCL13 CXCL8 IFNG IL17A
3
Show member pathways
11.88 CXCL10 CXCL13 CXCL8 MYH9
4
Show member pathways
11.83 CXCL10 CXCL8 IFNG
5
Show member pathways
11.79 CXCL10 CXCL8 IFNG IL17A
6 11.66 CXCL10 CXCL8 IFNG
7
Show member pathways
11.61 CXCL10 CXCL13 CXCL8
8 11.45 CXCL8 IFNG IL17A
9 11.37 CXCL8 IFNG MYH9
10 11.2 CXCL8 IFNG
11 11.12 CXCL10 IFNG
12 11.06 CXCL10 CXCL13
13 11.02 IFNG IL17A
14 10.78 CXCL10 CXCL13 IFNG IL17A
15 10.66 CXCL10 CXCL13 CXCL8 IL17A
16 10.49 CXCL10 CXCL13 CXCL8 IL17A

GO Terms for Asymptomatic Neurosyphilis

Biological processes related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 CXCL10 CXCL13 CXCL8 IL17A
2 cell-cell signaling GO:0007267 9.71 CXCL10 CXCL13 IL17A
3 defense response to virus GO:0051607 9.7 CXCL10 DDX41 IFNG
4 cellular response to lipopolysaccharide GO:0071222 9.69 CXCL10 CXCL13 CXCL8
5 chemotaxis GO:0006935 9.67 CXCL10 CXCL13 CXCL8
6 defense response GO:0006952 9.63 CXCL10 CXCL13 CXCL8
7 neutrophil chemotaxis GO:0030593 9.58 CXCL10 CXCL13 CXCL8
8 immune response GO:0006955 9.55 CXCL10 CXCL13 CXCL8 IFNG IL17A
9 chemokine-mediated signaling pathway GO:0070098 9.54 CXCL10 CXCL13 CXCL8
10 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.5 CXCL10 CXCL13 CXCL8
11 positive regulation of osteoclast differentiation GO:0045672 9.48 IFNG IL17A
12 regulation of signaling receptor activity GO:0010469 9.35 CXCL10 CXCL13 CXCL8 IFNG IL17A
13 positive regulation of interleukin-23 production GO:0032747 9.26 IFNG IL17A
14 leukocyte chemotaxis GO:0030595 8.8 CXCL10 CXCL13 CXCL8

Molecular functions related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CXCR3 chemokine receptor binding GO:0048248 9.16 CXCL10 CXCL13
2 chemokine activity GO:0008009 9.13 CXCL10 CXCL13 CXCL8
3 cytokine activity GO:0005125 9.02 CXCL10 CXCL13 CXCL8 IFNG IL17A

Sources for Asymptomatic Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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