MCID: ASY002
MIFTS: 41

Asymptomatic Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Asymptomatic Neurosyphilis

MalaCards integrated aliases for Asymptomatic Neurosyphilis:

Name: Asymptomatic Neurosyphilis 12 15 32
Neurosyphilis 43 71
Neurosyphilis, Asymptomatic 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10035
ICD9CM 34 094.3
MeSH 43 D009494
SNOMED-CT 67 37754005
ICD10 32 A52.2
UMLS 71 C0027927 C0153167

Summaries for Asymptomatic Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in mild meningitis.

MalaCards based summary : Asymptomatic Neurosyphilis, also known as neurosyphilis, is related to meningovascular neurosyphilis and tabes dorsalis, and has symptoms including syphilitic chancre An important gene associated with Asymptomatic Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and skin.

Wikipedia : 74 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Asymptomatic Neurosyphilis

Diseases related to Asymptomatic Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 391)
# Related Disease Score Top Affiliating Genes
1 meningovascular neurosyphilis 33.4 MYH9 CXCL13 CD40LG CD4
2 tabes dorsalis 33.2 MYH9 CXCL13 CD4
3 tertiary neurosyphilis 32.9 MYH9 ITPA CXCL13 CD40LG CD4
4 syphilitic meningitis 30.9 CXCL13 CD40LG CD4
5 optic papillitis 30.8 CD40LG CD4
6 chorioretinitis 30.7 CD40LG CD4
7 secondary syphilis 30.6 MYH9 CD40LG CD4
8 facial paralysis 30.6 CD40LG CD4
9 syphilis 30.6 MYH9 CD40LG CD4
10 neuroretinitis 30.5 CD40LG CD4
11 aortitis 30.5 CD40LG CD4
12 cranial nerve palsy 30.5 CD40LG CD4
13 primary syphilis 30.4 MYH9 CD40LG CD4
14 chronic meningitis 30.4 CD40LG CD4
15 viral encephalitis 30.3 CD40LG CD4
16 papilledema 30.3 CD40LG CD4
17 cysticercosis 30.3 CD40LG CD4
18 congenital syphilis 30.2 MYH9 CD40LG CD4
19 tertiary syphilis 30.2 MYH9 CXCL13 CD40LG CD4
20 mastoiditis 30.1 CD40LG CD4
21 iritis 30.1 CD40LG CD4
22 iridocyclitis 30.1 CD40LG CD4
23 panuveitis 30.1 CD40LG CD4
24 orchitis 30.1 CD40LG CD4
25 central nervous system vasculitis 30.1 CD40LG CD4
26 urethritis 30.1 CD40LG CD4
27 aseptic meningitis 29.9 CXCL13 CD40LG
28 sarcoidosis 1 29.9 CXCL5 CD40LG CD4
29 progressive multifocal leukoencephalopathy 29.9 CD40LG CD4
30 latent syphilis 29.7 MYH9 CXCL13 CD40LG CD4
31 pancytopenia 29.7 ITPA CD40LG CD4
32 parenchymatous neurosyphilis 12.6
33 neurosyphilis 11.8
34 late congenital syphilis 11.7
35 cerebral atrophy 11.6
36 argyll robertson pupil 11.5
37 aids - neurological complications 11.2
38 immune deficiency disease 10.6
39 encephalitis 10.6
40 transient pseudohypoaldosteronism 10.6
41 dementia 10.5
42 malaria 10.5
43 status epilepticus 10.4
44 human immunodeficiency virus type 1 10.4
45 eye lymphoma 10.4 CXCL13 CD4
46 ataxia and polyneuropathy, adult-onset 10.4
47 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
48 acquired immunodeficiency syndrome 10.3
49 cork-handlers' disease 10.3 CD40LG CD4
50 american histoplasmosis 10.3 CD40LG CD4

Graphical network of the top 20 diseases related to Asymptomatic Neurosyphilis:



Diseases related to Asymptomatic Neurosyphilis

Symptoms & Phenotypes for Asymptomatic Neurosyphilis

UMLS symptoms related to Asymptomatic Neurosyphilis:


syphilitic chancre

Drugs & Therapeutics for Asymptomatic Neurosyphilis

Drugs for Asymptomatic Neurosyphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
3 Penicillin G Benzathine Phase 4
4 Penicillin G Procaine Phase 4
5 penicillins Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
9
Azithromycin Approved Phase 3 83905-01-5 447043 55185
10 Antiparasitic Agents Phase 3
11 Antiprotozoal Agents Phase 3
12 Antimalarials Phase 3
13
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
14
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
15 Calcium, Dietary Phase 2
16 Hormones Phase 2
17
Calcium Nutraceutical Phase 2 7440-70-2 271
18
Ceftriaxone Approved 73384-59-5 5361919 5479530

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
3 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
4 To Study the Efficacy of Teriparatide in Improving Remodeling of Foot Bones in Chronic Charcot Neuroarthropathy in Patients With Diabetes Mellitus. Unknown status NCT02023411 Phase 2 Teriparatide
5 A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals Completed NCT00000648 Penicillin G potassium;Ceftriaxone sodium
6 Xijing HOSPITAL, Fourth Military Medical University, China Completed NCT00921648
7 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441

Search NIH Clinical Center for Asymptomatic Neurosyphilis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Probenecid

Cochrane evidence based reviews: neurosyphilis

Genetic Tests for Asymptomatic Neurosyphilis

Anatomical Context for Asymptomatic Neurosyphilis

MalaCards organs/tissues related to Asymptomatic Neurosyphilis:

40
Testes, Brain, Skin, Heart, Spinal Cord, Eye, Bone

Publications for Asymptomatic Neurosyphilis

Articles related to Asymptomatic Neurosyphilis:

(show top 50) (show all 2176)
# Title Authors PMID Year
1
Frequency of Screening and Prevalence of Neurosyphilis in Stroke Population. 61
32570248 2020
2
Persistent Verrucous Plaques in an HIV-Positive Patient with Secondary and Neurosyphilis. 61
32496387 2020
3
Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests. 61
32578862 2020
4
Sensitivity and Specificity of Treponemal-specific Tests for the Diagnosis of Syphilis. 61
32578866 2020
5
The potential for CXCL13 in CSF as a differential diagnostic tool in central nervous system infection. 61
32479125 2020
6
Reply to query: Cerebrospinal fluid tests for neurosyphilis diagnosis by Drago et al. 61
32366607 2020
7
Increased CCL24 and CXCL7 levels in the cerebrospinal fluid of patients with neurosyphilis. 61
32419252 2020
8
Mixed-pattern syphilitic alopecia of the scalp associated with uveitis and asymptomatic neurosyphilis. 61
32441352 2020
9
Cerebrospinal fluid tests for neurosyphilis diagnosis. 61
32366605 2020
10
An epidemiological study of syphilis and predictors of treatment failure in University Malaya Medical Centre. 61
32467532 2020
11
Syphilitic aortitis: still a current common cause of aneurysm of the tubular portion of ascending aorta. 61
31951962 2020
12
Peripheral blood mononuclear cell microRNA profiles in syphilitic patients with serofast status. 61
32333247 2020
13
The Devil Is in the Details: Neurological Diseases Presenting as Religious Hallucinations in Two Literary Works. 61
32434181 2020
14
Neuroimaging Features, Follow-Up Analyses, and Comparisons Between Asymptomatic and Symptomatic Neurosyphilis. 61
32124253 2020
15
The Treponema pallidum outer membrane protein Tp92 activates endothelial cells via the chemerin/CMKLR1 pathway. 61
32173267 2020
16
Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance. 61
32331231 2020
17
Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection. 61
32251462 2020
18
General paresis of insane: A forgotten entity. 61
32415032 2020
19
Differential diagnosis of temporal lobe lesions with hyperintense signal on T2-weighted and FLAIR sequences: pictorial essay. 61
32336830 2020
20
Imaging of Diffuse Neurosyphilis Affecting the Corticospinal Tracts and Cerebellum. 61
31730295 2020
21
Clinical and laboratory characteristics of ocular syphilis and neurosyphilis among individuals with and without HIV infection. 61
32220852 2020
22
[Ocular syphilis, a re-emergent pathology: Series of 12 patients in one Hospital, 2017]. 61
31301942 2020
23
Neurosyphilis Presenting as Mania and Psychosis After Incidental Treatment With Cephalexin: A Case Report and Literature Review of Jarisch-Herxheimer Reactions. 61
31331661 2020
24
Cerebrospinal fluid treponemal antibody titres: a breakthrough in the diagnosis of neurosyphilis. 61
32033979 2020
25
Ocular and neurosyphilis: epidemiology and approach to management. 61
31789673 2020
26
Neurosyphilis: Old Disease, New Implications for Emergency Physicians. 61
32064424 2020
27
Neurosyphilis presenting with myelitis-case series and literature review. 61
31859039 2020
28
Eyes As the Window to Syphilis: A Rare Case of Ocular Syphilis As the Initial Presentation of Syphilis. 61
32206462 2020
29
Prevalence of Self-Reported Neurologic and Ocular Symptoms in Early Syphilis Cases. 61
32103243 2020
30
Ocular syphilis: case series (2000-2015) from 2 tertiary care centres in Montreal, Canada. 61
31712031 2020
31
False positives in the ultrasound diagnosis of giant cell arteritis: some diseases can also show the halo sign. 61
31953951 2020
32
Neurosyphilis presenting as acute ischemic stroke. 61
31941739 2020
33
Neurosyphilis vasculitis manifesting as ischemic stroke. 61
32187345 2020
34
Ocular syphilis in an immunocompetent man. 61
32528847 2020
35
Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis. 61
32117023 2020
36
Cerebrospinal fluid TPPA titres in the diagnosis of neurosyphilis. 61
31959701 2020
37
[Diagnostic problems and treatment of late neurosyphilis in a young patient: a case report]. 61
32307418 2020
38
The great imitator: Mesial temporal alterations in MRI in an atypical case of neurosyphilis. 61
28863830 2020
39
UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS. 61
28816862 2020
40
Cerebral Impaludation - An Ignoble Procedure between Two Nobel Prizes: Frontal Lobe Lesions before the Introduction of Leucotomy. 61
32320974 2020
41
[Damage to the inner ear with syphilitic infection]. 61
32476396 2020
42
Molecular diagnostic of syphilis. 61
32111369 2020
43
High HbA1c level is correlated with blood-brain barrier disruption in syphilis patients. 61
31440863 2020
44
Immunoblot and Polymerase Chain Reaction to Diagnose Ocular Syphilis and Neurosyphilis in HIV-positive and HIV-negative Patients. 61
31944129 2020
45
Clinical prediction and diagnosis of neurosyphilis in HIV-negative patients: a case-control study. 61
31791265 2019
46
Neurosyphilis Presenting as Intermittent Explosive Disorder and Acute Psychosis. 61
31938625 2019
47
Neurosyphilis presenting as visually asymptomatic bilateral optic perineuritis. 61
31871011 2019
48
Neurosyphilis. Reply. 61
31826358 2019
49
Creutzfeldt-Jakob Disease Mimicking Neurosyphilis: A Complex Presentation, Histopathological Findings, and Special Precautions for Autopsy. 61
31306170 2019
50
Neurosyphilis. 61
31826356 2019

Variations for Asymptomatic Neurosyphilis

Expression for Asymptomatic Neurosyphilis

Search GEO for disease gene expression data for Asymptomatic Neurosyphilis.

Pathways for Asymptomatic Neurosyphilis

Pathways related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 MYH9 CXCL5 CXCL13 CD40LG CD4 CCL15
2
Show member pathways
12.91 CXCL5 CXCL13 CD40LG CD4 CCL15
3
Show member pathways
12.21 CXCL5 CXCL13 CD4 CCL15
4
Show member pathways
12.17 MYH9 CXCL5 CXCL13 CD40LG CD4 CCL15
5
Show member pathways
11.83 CXCL5 CXCL13 CCL15
6 10.98 CD40LG CD4
7 10.16 CXCL5 CXCL13 CD40LG CCL15

GO Terms for Asymptomatic Neurosyphilis

Biological processes related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.85 PILRA CXCL5 CXCL13 CD40LG CD4 CCL15
2 cell-cell signaling GO:0007267 9.63 CXCL5 CXCL13 CCL15
3 inflammatory response GO:0006954 9.62 CXCL5 CXCL13 CD40LG CCL15
4 chemotaxis GO:0006935 9.58 CXCL5 CXCL13 CCL15
5 leukocyte chemotaxis GO:0030595 9.43 CXCL5 CXCL13
6 cell chemotaxis GO:0060326 9.43 CXCL5 CXCL13 CCL15
7 neutrophil chemotaxis GO:0030593 9.33 CXCL5 CXCL13 CCL15
8 chemokine-mediated signaling pathway GO:0070098 9.13 CXCL5 CXCL13 CCL15
9 immune response GO:0006955 9.02 CXCL5 CXCL13 CD40LG CD4 CCL15

Molecular functions related to Asymptomatic Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL5 CXCL13 CD40LG CCL15
2 CXCR chemokine receptor binding GO:0045236 9.16 CXCL5 CXCL13
3 chemokine activity GO:0008009 8.8 CXCL5 CXCL13 CCL15

Sources for Asymptomatic Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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