ATHS
MCID: ATH013
MIFTS: 60

Atherosclerosis Susceptibility (ATHS)

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Atherosclerosis Susceptibility

MalaCards integrated aliases for Atherosclerosis Susceptibility:

Name: Atherosclerosis Susceptibility 58
Atherosclerosis 58 39 12 77 30 56 44 45 15 64 17 74
Atherosclerosis, Susceptibility to 58 13 6
Atherogenic Lipoprotein Phenotype; Alp 58
Atherogenic Lipoprotein Phenotype 58
Arteriosclerosis 74
Aths 58
Alp 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant
? same as ldlr


HPO:

33
atherosclerosis susceptibility:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:1936
OMIM 58 108725
ICD9CM 36 440
MeSH 45 D050197
SNOMED-CT 69 38716007
ICD10 34 I25.1 I70
MedGen 43 C1531719
SNOMED-CT via HPO 70 190785000 22298006 263681008

Summaries for Atherosclerosis Susceptibility

MedlinePlus : 44 Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body. Atherosclerosis can lead to serious problems, including Coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack. Carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke. Peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections. Atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have it until they have a medical emergency. A physical exam, imaging, and other diagnostic tests can tell if you have it. Medicines can slow the progress of plaque buildup. Your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Atherosclerosis Susceptibility is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Interleukin-4 and 13 signaling. The drugs Liver Extracts and insulin have been mentioned in the context of this disorder. Affiliated tissues include Endothelium and Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

OMIM : 58 The atherogenic lipoprotein phenotype (ALP) is a common heritable trait characterized by a preponderance of small, dense low density lipoprotein (LDL) particles (subclass pattern B), increased levels of triglyceride-rich lipoproteins, reduction in high density lipoprotein, and a 3-fold increased risk of myocardial infarction (summary by Nishina et al., 1992). The so-called atherogenic lipoprotein phenotype was shown by Austin et al. (1988) to be independently associated with an increased risk for coronary artery disease. Allayee et al. (1998) concluded, furthermore, that there is a genetically based association between familial combined hyperlipidemia (FCHL; 144250) and small, dense LDL particles and that the genetic determinants for LDL particle size are shared, at least in part, among FCHL families and the more general population at risk for coronary artery disease. Juo et al. (1998) concluded from a bivariate segregation analysis of small, dense LDL particles and elevated apolipoprotein B levels (APOB; 107730), which are commonly found together in members of FCHL families, that the 2 traits share a common major gene plus individual polygenic components. The common major gene was estimated to explain 37% of the variance of adjusted LDL particle size and 23% of the variance of adjusted apoB levels. (108725)

PubMed Health : 64 About atherosclerosis: Atherosclerosis (ath-er-o-skler-O-sis) is a disease in which plaque (plak) builds up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body.Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death.

Wikipedia : 77 Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.... more...

Related Diseases for Atherosclerosis Susceptibility

Diseases related to Atherosclerosis Susceptibility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 708)
# Related Disease Score Top Affiliating Genes
1 cerebral atherosclerosis 34.6 APOA1 APOE
2 generalized atherosclerosis 34.4 APOE CRP
3 carotid stenosis 32.6 APOE CDKN2B-AS1 CRP
4 carotid artery disease 32.5 APOA1 APOB APOE CCL2 CRP
5 arteriosclerosis 32.5 APOA1 APOB APOE CCL2 CRP PON1
6 hypercholesterolemia, familial 32.5 APOA1 APOB APOE CRP LDLR PON1
7 hepatic lipase deficiency 32.5 APOA1 APOE
8 peripheral vascular disease 32.2 APOA1 APOB CRP VCAM1
9 cerebrovascular disease 32.2 APOA1 APOB APOE CRP LDLR PON1
10 familial lcat deficiency 32.1 APOA1 APOE
11 vascular disease 32.0 APOA1 APOB APOE CCL2 CRP LDLR
12 coronary heart disease 1 31.8 APOA1 APOB APOE CDKN2B-AS1 CRP H19
13 lipid metabolism disorder 31.2 APOA1 APOB APOE CRP LDLR
14 heart disease 31.2 APOA1 APOB APOE CRP H19 LDLR
15 ischemic heart disease 31.1 APOA1 APOB APOE CRP
16 hypertriglyceridemia, familial 31.0 APOA1 APOB APOE
17 chronic kidney failure 30.9 APOB CRP PON1 TUG1 VCAM1
18 aortic aneurysm, familial abdominal, 1 30.9 APOE CCL2 CDKN2B-AS1 H19
19 peripheral artery disease 30.8 APOB CCL2 CDKN2B-AS1 CRP VCAM1
20 stroke, ischemic 30.8 APOB APOE CDKN2B-AS1 CRP PON1 TLR4
21 homozygous familial hypercholesterolemia 30.8 APOB APOE LDLR
22 coronary stenosis 30.7 APOA1 APOB APOE CRP PON1
23 macular degeneration, age-related, 1 30.5 APOB APOE CCL2 CRP
24 vasculitis 30.5 CCL2 CRP VCAM1
25 acute myocardial infarction 30.4 APOA1 APOB CDKN2B-AS1 CRP
26 rheumatoid arthritis 30.4 CCL2 CRP H19 TLR4 VCAM1
27 coronary artery anomaly 30.4 APOA1 APOB CRP PON1
28 tangier disease 30.4 APOA1 APOB APOE
29 defective apolipoprotein b-100 30.3 APOB APOE LDLR
30 lipoprotein glomerulopathy 30.3 APOB APOE LDLR
31 xanthomatosis 30.2 APOB APOE LDLR
32 hypoalphalipoproteinemia, primary 30.2 APOA1 APOB LDLR
33 periodontitis 30.2 CCL2 CDKN2B-AS1 CRP TLR4
34 aortic atherosclerosis 30.2 APOE LDLR PON1
35 diabetes mellitus 30.2 APOA1 APOB CDKN2B-AS1 CRP PON1 TUG1
36 endometriosis 30.2 CCL2 CDKN2B-AS1 ESR1 H19
37 lecithin:cholesterol acyltransferase deficiency 30.2 APOA1 APOB APOE LDLR
38 takayasu arteritis 30.2 CRP PON1 VCAM1
39 overnutrition 30.2 APOB CCL2 CRP
40 diabetes mellitus, noninsulin-dependent 30.1 APOA1 APOB APOE CCL2 CDKN2B-AS1 CRP
41 bacterial infectious disease 30.1 CCL2 CRP TLR4
42 pneumonia 30.0 CCL2 CRP TLR4
43 body mass index quantitative trait locus 11 29.9 APOA1 APOB APOE CCL2 CRP H19
44 chorioamnionitis 29.9 CCL2 CRP TLR4
45 arteries, anomalies of 29.9 APOA1 APOB APOE CCL2 CRP LDLR
46 hyperlipoproteinemia, type iii 29.9 APOA1 APOB APOE LDLR
47 arcus corneae 29.8 APOA1 APOB APOE LDLR
48 hyperalphalipoproteinemia 1 29.8 APOA1 APOB APOE LDLR
49 abetalipoproteinemia 29.8 APOA1 APOB APOE LDLR
50 myocardial infarction 29.8 APOA1 APOB APOE CCL2 CDKN2B-AS1 CRP

Graphical network of the top 20 diseases related to Atherosclerosis Susceptibility:



Diseases related to Atherosclerosis Susceptibility

Symptoms & Phenotypes for Atherosclerosis Susceptibility

Human phenotypes related to Atherosclerosis Susceptibility:

33
# Description HPO Frequency HPO Source Accession
1 hypertriglyceridemia 33 HP:0002155
2 myocardial infarction 33 HP:0001658
3 decreased hdl cholesterol concentration 33 HP:0003233

Symptoms via clinical synopsis from OMIM:

58
Cardiac:
increased myocardial infarction risk

Lab:
preponderance of small, dense low density lipoprotein (ldl) particles (subclass pattern b)
increased triglyceride-rich lipoproteins
reduced high density lipoprotein

Clinical features from OMIM:

108725

UMLS symptoms related to Atherosclerosis Susceptibility:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE LDLR
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LDLR

MGI Mouse Phenotypes related to Atherosclerosis Susceptibility:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.32 ALOX5 APOA1 APOB APOE CRP ESR1

Drugs & Therapeutics for Atherosclerosis Susceptibility

PubMedHealth treatment related to Atherosclerosis Susceptibility: 64

Treatments for atherosclerosis may include lifestyle changes, medicines, and medical procedures or surgery.The goals of treatment include:Relieving symptomsReducing risk factors in an effort to slow or stop the buildup of plaqueLowering the risk of blood clots formingWidening or bypassing plaque-clogged arteriesPreventing atherosclerosis-related diseases

Drugs for Atherosclerosis Susceptibility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable
2 insulin Not Applicable
3 Insulin, Globin Zinc Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 How Does Dietary Carbohydrate Influence the Formation of an Atherogenic Lipoprotein Phenotype (ALP)? Completed NCT01790984 Not Applicable
2 Genetic Mapping of Atherogenic Lipoprotein Phenotypes Completed NCT00005465
3 Lipids Profile in Subclinical Hypothyroidism Terminated NCT00962221
4 Lipids Profile in Primary Hyperparathyroidism Terminated NCT00961701
5 Genetic Epidemiology of Hypertriglyceridemia Completed NCT00005368
6 Effects of Almond Intake on Atherogenic Lipoprotein Particles Completed NCT01792648 Not Applicable
7 Resistant Starch Insulin Sensitivity Trial Completed NCT01027325 Not Applicable

Search NIH Clinical Center for Atherosclerosis Susceptibility

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: atherosclerosis

Genetic Tests for Atherosclerosis Susceptibility

Genetic tests related to Atherosclerosis Susceptibility:

# Genetic test Affiliating Genes
1 Atherosclerosis 30

Anatomical Context for Atherosclerosis Susceptibility

MalaCards organs/tissues related to Atherosclerosis Susceptibility:

42
Heart, Endothelial, Kidney, Liver, Lung, Smooth Muscle, T Cells
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Atherosclerosis Susceptibility:
# Tissue Anatomical CompartmentCell Relevance
1 Endothelium Arteries Arterial Endothelial Cells Affected by disease
2 Heart Coronary Capillary Plexus Affected by disease
3 Heart Coronary Vessels Affected by disease

Publications for Atherosclerosis Susceptibility

Articles related to Atherosclerosis Susceptibility:

(show top 50) (show all 3053)
# Title Authors Year
1
Resolving atherosclerosis and Alzheimer disease. ( 30903022 )
2019
2
Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β2-microglobulin-related amyloidosis and indoxyl sulfate-induced atherosclerosis-Oshima Award Address 2016. ( 29869756 )
2019
3
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice. ( 30850299 )
2019
4
Reply: "Diabetes-related factors and abdominal aortic aneurysm events: the Atherosclerosis Risk in Communities study". ( 30700391 )
2019
5
Association between Negatively Charged Low-Density Lipoprotein L5 and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients. ( 30717448 )
2019
6
Rheumatoid Arthritis: Atherosclerosis Imaging and Cardiovascular Risk Assessment Using Machine and Deep Learning-Based Tissue Characterization. ( 30684090 )
2019
7
Regional 18F-FDG uptake indicates coronary artery anomaly in a middle-aged patient with no atherosclerosis risk. ( 30820815 )
2019
8
Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study. ( 30439332 )
2019
9
Assessment of biomarkers of inflammation and premature atherosclerosis in adolescents with type-1 diabetes mellitus. ( 30710485 )
2019
10
Changes in CDKN2A/2B expression associate with T-cell phenotype modulation in atherosclerosis and type 2 diabetes mellitus. ( 30176239 )
2019
11
Helicobacter pylori infection combined with non-alcoholic fatty liver disease increase the risk of atherosclerosis: Focus in carotid artery plaque. ( 30817593 )
2019
12
Protective effect of HSP27 in atherosclerosis and coronary heart disease by inhibiting reactive oxygen species. ( 29232010 )
2019
13
The role of serial carotid intima-media thickness assessment as a surrogate marker of atherosclerosis control in patients with recent myocardial infarction. ( 31043988 )
2019
14
Association of Apical Periodontitis With Cardiovascular Disease via Noninvasive Assessment of Endothelial Function and Subclinical Atherosclerosis. ( 31030979 )
2019
15
Serum magnesium and the prevalence of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study. ( 30658844 )
2019
16
Cardiac biomarkers but not measures of vascular atherosclerosis predict mortality in patients with peripheral artery disease. ( 30981846 )
2019
17
Associations of edge-detected and manual-traced common carotid artery intima-media thickness with incident peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis. ( 31023166 )
2019
18
Monocyte-platelet cross-talk in peripheral artery disease-how much does the pathogenesis of atherosclerosis depend on anatomical location? ( 31032300 )
2019
19
Noninvasive assessment of subclinical atherosclerosis in patients with rosacea. ( 30717569 )
2019
20
Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis. ( 30346597 )
2019
21
Arousal index as a marker of carotid artery atherosclerosis in patients with obstructive sleep apnea syndrome. ( 29779142 )
2019
22
Epicardial adipose tissue thickness as a new risk factor for atherosclerosis in patients with ankylosing spondylitis. ( 30248026 )
2019
23
The Relationship of Ankylosing Spondylitis and Subclinical Atherosclerosis: A Systemic Review and Meta-Analysis. ( 30497278 )
2019
24
Evaluation of subclinical atherosclerosis using ultrasound radiofrequency data technology in patients diagnosed with ankylosing spondylitis. ( 30182506 )
2019
25
Common Pathogenesis of Acne Vulgaris and Atherosclerosis. ( 30073565 )
2019
26
Therapeutic Target Identified for Slowing Early Atherosclerosis in Progeria: Researchers have identifi ed a new molecular mechanism involved in the premature development of atherosclerosis in progeria. ( 31033169 )
2019
27
Recurrent atherosclerosis complications as a mechanism for stent failure. ( 31034959 )
2019
28
Nε-carboxymethyl-lysine-induced PI3K/Akt signaling inhibition promotes foam cell apoptosis and atherosclerosis progression. ( 31035012 )
2019
29
Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis. ( 31035303 )
2019
30
An update on the tools for creating transgenic animal models of human diseases - focus on atherosclerosis. ( 31038578 )
2019
31
Angiographical Identification of Intracranial, Atherosclerosis-Related, Large Vessel Occlusion in Endovascular Treatment. ( 31040811 )
2019
32
Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. ( 31042164 )
2019
33
Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis. ( 31043077 )
2019
34
Coronary Intimal Thickening Begins in Fetuses and Progresses in Pediatric Population and Adolescents to Atherosclerosis. ( 31088126 )
2019
35
Relation of Isolated Systolic Hypertension and Pulse Pressure to High-Sensitivity Cardiac Troponin-T and N-Terminal pro-B-Type Natriuretic Peptide in Older Adults (from the Atherosclerosis Risk in Communities Study). ( 31088661 )
2019
36
Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE-/- mice. ( 31088858 )
2019
37
The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis. ( 31089324 )
2019
38
Correction to: Use of oral anticoagulant drugs is associated with carotid intraplaque hemorrhage in atherosclerosis patients: a meta-analysis. ( 31089987 )
2019
39
Greater Adherence to Life's Simple 7 Is Associated With Less Arterial Stiffness: the Atherosclerosis Risk in Communities (ARIC) Study. ( 31090885 )
2019
40
B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B1-Cell Responses. ( 31092015 )
2019
41
Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice. ( 31093011 )
2019
42
Mitochondrial Dysfunction in Atherosclerosis. ( 31095428 )
2019
43
The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis. ( 31095432 )
2019
44
Lipoproteins in Atherosclerosis Process. ( 31096892 )
2019
45
Synthesis and Automated Labeling of [18F]Darapladib, a Lp-PLA2 Ligand, as Potential PET Imaging Tool of Atherosclerosis. ( 31097993 )
2019
46
NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy. ( 31100709 )
2019
47
Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease. ( 31102408 )
2019
48
Risk of obstructive coronary artery disease and major adverse cardiac events in patients with noncoronary atherosclerosis: Insights from the Veterans Affairs Clinical Assessment, Reporting, and Tracking (CART) Program. ( 31102799 )
2019
49
Development, synthesis, and 68Ga-Labeling of a Lipophilic complexing agent for atherosclerosis PET imaging. ( 31102933 )
2019
50
Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr-/- mice. ( 31102954 )
2019

Variations for Atherosclerosis Susceptibility

ClinVar genetic disease variations for Atherosclerosis Susceptibility:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ESR1 ESR1, IVS1, T-C, -401 single nucleotide variant drug response,risk factor
2 ALOX5 ALOX5, VARIANT PROMOTER SP1 BINDING undetermined variant drug response,risk factor
3 VEGFA NM_001025366.2(VEGFA): c.-2055A> C single nucleotide variant Benign rs699947 GRCh38 Chromosome 6, 43768652: 43768652
4 VEGFA NM_001025366.2(VEGFA): c.-2055A> C single nucleotide variant Benign rs699947 GRCh37 Chromosome 6, 43736389: 43736389

Copy number variations for Atherosclerosis Susceptibility from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 207754 6 160900000 164400000 Gain LPA Atherosclerosis

Expression for Atherosclerosis Susceptibility

Search GEO for disease gene expression data for Atherosclerosis Susceptibility.

Pathways for Atherosclerosis Susceptibility

GO Terms for Atherosclerosis Susceptibility

Cellular components related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.63 APOA1 APOB APOE LDLR TLR4 VCAM1
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.61 APOB APOE LDLR
3 high-density lipoprotein particle GO:0034364 9.58 APOA1 APOE PON1
4 very-low-density lipoprotein particle GO:0034361 9.54 APOA1 APOB APOE
5 endocytic vesicle lumen GO:0071682 9.5 APOA1 APOB APOE
6 spherical high-density lipoprotein particle GO:0034366 9.48 APOA1 PON1
7 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
8 chylomicron GO:0042627 9.43 APOA1 APOB APOE
9 intermediate-density lipoprotein particle GO:0034363 9.13 APOA1 APOB APOE
10 low-density lipoprotein particle GO:0034362 8.92 APOA1 APOB APOE LDLR
11 extracellular space GO:0005615 10.1 ALOX5 APOA1 APOB APOE CCL2 CRP

Biological processes related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.93 APOE CDKN2B-AS1 ESR1 LDLR
2 receptor-mediated endocytosis GO:0006898 9.91 APOA1 APOB APOE LDLR
3 lipid transport GO:0006869 9.85 APOA1 APOB APOE LDLR
4 steroid metabolic process GO:0008202 9.84 APOA1 APOB APOE LDLR
5 cholesterol homeostasis GO:0042632 9.76 APOA1 APOB APOE LDLR
6 retinoid metabolic process GO:0001523 9.75 APOA1 APOB APOE
7 cholesterol transport GO:0030301 9.7 APOA1 APOB LDLR
8 triglyceride catabolic process GO:0019433 9.69 APOA1 APOB APOE
9 reverse cholesterol transport GO:0043691 9.67 APOA1 APOE
10 high-density lipoprotein particle remodeling GO:0034375 9.67 APOA1 APOE
11 positive regulation of lipid biosynthetic process GO:0046889 9.67 APOA1 APOE
12 lipoxygenase pathway GO:0019372 9.66 ALOX5 PON1
13 positive regulation of cholesterol efflux GO:0010875 9.66 APOE PON1
14 low-density lipoprotein particle remodeling GO:0034374 9.65 APOB APOE
15 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 CCL2 TLR4
16 regulation of cholesterol metabolic process GO:0090181 9.65 APOE LDLR
17 cholesterol efflux GO:0033344 9.65 APOA1 APOB APOE
18 high-density lipoprotein particle assembly GO:0034380 9.64 APOA1 APOE
19 phospholipid efflux GO:0033700 9.63 APOA1 APOE
20 regulation of protein metabolic process GO:0051246 9.62 APOE LDLR
21 positive regulation of cholesterol esterification GO:0010873 9.62 APOA1 APOE
22 very-low-density lipoprotein particle remodeling GO:0034372 9.61 APOA1 APOE
23 chylomicron assembly GO:0034378 9.61 APOA1 APOB APOE
24 regulation of Cdc42 protein signal transduction GO:0032489 9.59 APOA1 APOE
25 regulation of cholesterol transport GO:0032374 9.58 APOA1 APOE
26 high-density lipoprotein particle clearance GO:0034384 9.58 APOA1 APOE LDLR
27 cholesterol import GO:0070508 9.57 APOA1 LDLR
28 very-low-density lipoprotein particle clearance GO:0034447 9.56 APOB APOE
29 cholesterol metabolic process GO:0008203 9.55 APOA1 APOB APOE LDLR PON1
30 chylomicron remnant clearance GO:0034382 9.54 APOB APOE LDLR
31 chylomicron remodeling GO:0034371 9.5 APOA1 APOB APOE
32 response to caloric restriction GO:0061771 9.49 APOE LDLR
33 lipoprotein biosynthetic process GO:0042158 9.43 APOA1 APOB APOE
34 lipoprotein metabolic process GO:0042157 9.26 APOA1 APOB APOE LDLR
35 lipoprotein catabolic process GO:0042159 8.8 APOB APOE LDLR
36 lipid metabolic process GO:0006629 10.04 APOA1 APOB APOE LDLR PON1
37 positive regulation of gene expression GO:0010628 10 APOB CDKN2B-AS1 CRP LDLR TLR4

Molecular functions related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.63 APOA1 APOE ESR1
2 amyloid-beta binding GO:0001540 9.58 APOA1 APOE LDLR
3 phospholipid binding GO:0005543 9.46 APOA1 APOB APOE PON1
4 low-density lipoprotein particle binding GO:0030169 9.43 CRP LDLR
5 lipid transporter activity GO:0005319 9.43 APOA1 APOB APOE
6 lipoprotein particle binding GO:0071813 9.37 APOA1 APOE
7 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.32 APOA1 APOE
8 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CRP
9 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE

Sources for Atherosclerosis Susceptibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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