Atherosclerosis Susceptibility (ALP)

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OMIM 57 108725 Disease Ontology 12 DOID:1936 ICD10 33 I25.1 I70 ICD9CM 35 440 MeSH 44 D050197

NCIt 50 C35768 C35771 SNOMED-CT 68 38716007 MedGen 42 C1531719 SNOMED-CT via HPO 69 263681008 22298006 190785000 UMLS 73 C0004153 C0003850

MedlinePlus : ⁴³ Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body. Atherosclerosis can lead to serious problems, including Coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack. Carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke. Peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections. Atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have it until they have a medical emergency. A physical exam, imaging, and other diagnostic tests can tell if you have it. Medicines can slow the progress of plaque buildup. Your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Atherosclerosis Susceptibility is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Interleukin-4 and 13 signaling. The drugs Liver Extracts and insulin have been mentioned in the context of this disorder. Affiliated tissues include Endothelium and Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

OMIM : ⁵⁷ The atherogenic lipoprotein phenotype (ALP) is a common heritable trait characterized by a preponderance of small, dense low density lipoprotein (LDL) particles (subclass pattern B), increased levels of triglyceride-rich lipoproteins, reduction in high density lipoprotein, and a 3-fold increased risk of myocardial infarction (summary by Nishina et al., 1992). The so-called atherogenic lipoprotein phenotype was shown by Austin et al. (1988) to be independently associated with an increased risk for coronary artery disease. Allayee et al. (1998) concluded, furthermore, that there is a genetically based association between familial combined hyperlipidemia (FCHL; 144250) and small, dense LDL particles and that the genetic determinants for LDL particle size are shared, at least in part, among FCHL families and the more general population at risk for coronary artery disease. Juo et al. (1998) concluded from a bivariate segregation analysis of small, dense LDL particles and elevated apolipoprotein B levels (APOB; 107730), which are commonly found together in members of FCHL families, that the 2 traits share a common major gene plus individual polygenic components. The common major gene was estimated to explain 37% of the variance of adjusted LDL particle size and 23% of the variance of adjusted apoB levels. (108725)

PubMed Health : ⁶³ About atherosclerosis: Atherosclerosis (ath-er-o-skler-O-sis) is a disease in which plaque (plak) builds up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body.Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death.

Wikipedia : ⁷⁶ Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.... more...

Clinical features from OMIM:

108725

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased free cholesterol	GR00340-A-2	9.26	APOA1 APOB APOE LDLR
2	Increased LDL uptake	GR00340-A-1	8.8	APOA1 APOE LDLR

Treatments for atherosclerosis may include lifestyle changes, medicines, and medical procedures or surgery.The goals of treatment include:Relieving symptomsReducing risk factors in an effort to slow or stop the buildup of plaqueLowering the risk of blood clots formingWidening or bypassing plaque-clogged arteriesPreventing atherosclerosis-related diseases

Search NIH Clinical Center for Atherosclerosis Susceptibility

epoprostenol epoprostenol sodium

isoxsuprine isoxsuprine hydrochloride

Search GEO for disease gene expression data for Atherosclerosis Susceptibility.