ALP
MCID: ATH013
MIFTS: 66

Atherosclerosis Susceptibility (ALP)

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Atherosclerosis Susceptibility

MalaCards integrated aliases for Atherosclerosis Susceptibility:

Name: Atherosclerosis Susceptibility 57 13
Atherosclerosis 57 38 12 76 29 55 43 44 15 63 73
Atherosclerosis, Susceptibility to 57 6
Atherogenic Lipoprotein Phenotype; Alp 57
Atherogenic Lipoprotein Phenotype 57
Arteriosclerosis 73
Aths 57
Alp 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant
? same as ldlr


HPO:

32
atherosclerosis susceptibility:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 108725
Disease Ontology 12 DOID:1936
ICD10 33 I25.1 I70
ICD9CM 35 440
MeSH 44 D050197
SNOMED-CT 68 38716007
MedGen 42 C1531719
SNOMED-CT via HPO 69 263681008 22298006 190785000

Summaries for Atherosclerosis Susceptibility

MedlinePlus : 43 Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body. Atherosclerosis can lead to serious problems, including Coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack. Carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke. Peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections. Atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have it until they have a medical emergency. A physical exam, imaging, and other diagnostic tests can tell if you have it. Medicines can slow the progress of plaque buildup. Your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Atherosclerosis Susceptibility is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Interleukin-4 and 13 signaling. The drugs Liver Extracts and insulin have been mentioned in the context of this disorder. Affiliated tissues include Endothelium and Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

OMIM : 57 The atherogenic lipoprotein phenotype (ALP) is a common heritable trait characterized by a preponderance of small, dense low density lipoprotein (LDL) particles (subclass pattern B), increased levels of triglyceride-rich lipoproteins, reduction in high density lipoprotein, and a 3-fold increased risk of myocardial infarction (summary by Nishina et al., 1992). The so-called atherogenic lipoprotein phenotype was shown by Austin et al. (1988) to be independently associated with an increased risk for coronary artery disease. Allayee et al. (1998) concluded, furthermore, that there is a genetically based association between familial combined hyperlipidemia (FCHL; 144250) and small, dense LDL particles and that the genetic determinants for LDL particle size are shared, at least in part, among FCHL families and the more general population at risk for coronary artery disease. Juo et al. (1998) concluded from a bivariate segregation analysis of small, dense LDL particles and elevated apolipoprotein B levels (APOB; 107730), which are commonly found together in members of FCHL families, that the 2 traits share a common major gene plus individual polygenic components. The common major gene was estimated to explain 37% of the variance of adjusted LDL particle size and 23% of the variance of adjusted apoB levels. (108725)

PubMed Health : 63 About atherosclerosis: Atherosclerosis (ath-er-o-skler-O-sis) is a disease in which plaque (plak) builds up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body.Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death.

Wikipedia : 76 Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.... more...

Related Diseases for Atherosclerosis Susceptibility

Diseases related to Atherosclerosis Susceptibility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 600)
# Related Disease Score Top Affiliating Genes
1 cerebral atherosclerosis 34.3 APOA1 APOE
2 generalized atherosclerosis 34.0 APOE CRP
3 arteriosclerosis 32.4 APOA1 APOB APOE CCL2 CRP PON1
4 hypercholesterolemia, familial 32.3 APOA1 APOB APOE CRP LDLR PON1
5 carotid stenosis 32.3 APOE CDKN2B-AS1 CRP
6 carotid artery disease 32.3 APOA1 APOB APOE CCL2 CRP
7 hepatic lipase deficiency 32.2 APOA1 APOE
8 cerebrovascular disease 32.0 APOA1 APOB APOE CRP LDLR PON1
9 peripheral vascular disease 31.9 APOA1 APOB CRP VCAM1
10 vascular disease 31.9 APOA1 APOB APOE CCL2 CRP LDLR
11 familial lcat deficiency 31.8 APOA1 APOE
12 coronary heart disease 1 31.6 APOA1 APOB APOE CDKN2B-AS1 CRP H19
13 heart disease 30.9 APOA1 APOB APOE CRP H19 LDLR
14 lipid metabolism disorder 30.6 APOA1 APOB APOE CRP LDLR
15 chronic kidney failure 30.6 APOB CRP PON1 TUG1 VCAM1
16 peripheral artery disease 30.6 APOB CCL2 CDKN2B-AS1 CRP VCAM1
17 ischemic heart disease 30.6 APOA1 APOB APOE CCL2 CRP
18 homozygous familial hypercholesterolemia 30.5 APOB APOE LDLR
19 coronary stenosis 30.5 APOA1 APOB APOE CRP PON1
20 hypertension, essential 30.4 APOA1 APOB CDKN2B-AS1 CRP PON1
21 aortic aneurysm, familial abdominal, 1 30.4 APOE CCL2 CDKN2B-AS1 CRP H19
22 stroke, ischemic 30.3 APOB APOE CDKN2B-AS1 CRP PON1 TLR4
23 rheumatoid arthritis 30.3 CCL2 CRP H19 TLR4 VCAM1
24 macular degeneration, age-related, 1 30.2 APOB APOE CCL2 CRP
25 vasculitis 30.2 CCL2 CRP VCAM1
26 coronary artery anomaly 30.2 APOA1 APOB CRP PON1
27 hypertriglyceridemia, familial 30.1 APOA1 APOB APOE
28 tangier disease 30.1 APOA1 APOB APOE
29 diabetes mellitus 30.1 APOA1 APOB CDKN2B-AS1 CRP PON1 TUG1
30 defective apolipoprotein b-100 30.1 APOB APOE LDLR
31 lipoprotein glomerulopathy 30.1 APOB APOE LDLR
32 periodontitis 30.0 CCL2 CDKN2B-AS1 CRP TLR4
33 xanthomatosis 30.0 APOB APOE LDLR
34 endometriosis 30.0 CCL2 CDKN2B-AS1 ESR1 H19
35 aortic atherosclerosis 30.0 APOE LDLR PON1
36 acute myocardial infarction 30.0 APOA1 APOB CDKN2B-AS1 CRP
37 takayasu arteritis 30.0 CRP PON1 VCAM1
38 overnutrition 29.9 APOB CCL2 CRP
39 inflammatory bowel disease 29.9 ALOX5 CCL2 CRP TLR4 VCAM1
40 diabetes mellitus, noninsulin-dependent 29.9 APOA1 APOB APOE CCL2 CDKN2B-AS1 CRP
41 arteries, anomalies of 29.8 APOA1 APOB APOE CCL2 CRP LDLR
42 lecithin:cholesterol acyltransferase deficiency 29.8 APOA1 APOB APOE LDLR
43 pneumonia 29.8 CCL2 CRP TLR4
44 chorioamnionitis 29.6 CCL2 CRP TLR4
45 arcus corneae 29.6 APOA1 APOB APOE LDLR
46 abetalipoproteinemia 29.6 APOA1 APOB APOE LDLR
47 adamantinoma of long bones 29.6 CDKN2B-AS1 ESR1 H19 HULC TUG1
48 pre-eclampsia 29.5 H19 TLR4 TUG1 VCAM1
49 body mass index quantitative trait locus 11 29.4 APOA1 APOB APOE CCL2 CRP H19
50 myocardial infarction 29.4 APOA1 APOB APOE CCL2 CDKN2B-AS1 CRP

Graphical network of the top 20 diseases related to Atherosclerosis Susceptibility:



Diseases related to Atherosclerosis Susceptibility

Symptoms & Phenotypes for Atherosclerosis Susceptibility

Symptoms via clinical synopsis from OMIM:

57
Cardiac:
increased myocardial infarction risk

Lab:
preponderance of small, dense low density lipoprotein (ldl) particles (subclass pattern b)
increased triglyceride-rich lipoproteins
reduced high density lipoprotein


Clinical features from OMIM:

108725

Human phenotypes related to Atherosclerosis Susceptibility:

32
# Description HPO Frequency HPO Source Accession
1 hypertriglyceridemia 32 HP:0002155
2 myocardial infarction 32 HP:0001658
3 decreased hdl cholesterol concentration 32 HP:0003233

UMLS symptoms related to Atherosclerosis Susceptibility:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE LDLR
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LDLR

MGI Mouse Phenotypes related to Atherosclerosis Susceptibility:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.32 ALOX5 APOA1 APOB APOE CRP ESR1

Drugs & Therapeutics for Atherosclerosis Susceptibility

PubMedHealth treatment related to Atherosclerosis Susceptibility: 63

Treatments for atherosclerosis may include lifestyle changes, medicines, and medical procedures or surgery.The goals of treatment include:Relieving symptomsReducing risk factors in an effort to slow or stop the buildup of plaqueLowering the risk of blood clots formingWidening or bypassing plaque-clogged arteriesPreventing atherosclerosis-related diseases

Drugs for Atherosclerosis Susceptibility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable
2 insulin Not Applicable
3 Insulin, Globin Zinc Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 How Does Dietary Carbohydrate Influence the Formation of an Atherogenic Lipoprotein Phenotype (ALP)? Completed NCT01790984 Not Applicable
2 Genetic Mapping of Atherogenic Lipoprotein Phenotypes Completed NCT00005465
3 Lipids Profile in Subclinical Hypothyroidism Terminated NCT00962221
4 Lipids Profile in Primary Hyperparathyroidism Terminated NCT00961701
5 Genetic Epidemiology of Hypertriglyceridemia Completed NCT00005368
6 Effects of Almond Intake on Atherogenic Lipoprotein Particles Completed NCT01792648 Not Applicable
7 Resistant Starch Insulin Sensitivity Trial Completed NCT01027325 Not Applicable

Search NIH Clinical Center for Atherosclerosis Susceptibility

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: atherosclerosis

Genetic Tests for Atherosclerosis Susceptibility

Genetic tests related to Atherosclerosis Susceptibility:

# Genetic test Affiliating Genes
1 Atherosclerosis 29

Anatomical Context for Atherosclerosis Susceptibility

MalaCards organs/tissues related to Atherosclerosis Susceptibility:

41
Endothelial, Heart, Kidney, Testes, Monocytes, Bone, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Atherosclerosis Susceptibility:
# Tissue Anatomical CompartmentCell Relevance
1 Endothelium Arteries Arterial Endothelial Cells Affected by disease
2 Heart Coronary Capillary Plexus Affected by disease
3 Heart Coronary Vessels Affected by disease

Publications for Atherosclerosis Susceptibility

Articles related to Atherosclerosis Susceptibility:

(show top 50) (show all 1037)
# Title Authors Year
1
Changes in CDKN2A/2B expression associate with T-cell phenotype modulation in atherosclerosis and type 2 diabetes mellitus. ( 30176239 )
2019
2
Effects of atorvastatin and/or probucol on recovery of atherosclerosis in high-fat-diet-fed apolipoprotein E-deficient mice. ( 30551396 )
2019
3
miR-449a induces EndMT, promotes the development of atherosclerosis by targeting the interaction between AdipoR2 and E-cadherin in Lipid Rafts. ( 30551487 )
2019
4
mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5. ( 30551500 )
2019
5
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro. ( 30551549 )
2019
6
Low molecule weight fucoidan mitigates atherosclerosis in ApoE (-/-) mouse model through activating multiple signal pathway. ( 30553304 )
2019
7
Subclinical atherosclerosis in asymptomatic carriers of persistent antiphospholipid antibodies positivity: A cross-sectional study. ( 30454720 )
2019
8
Folate-Modified Liposomes Loaded with Telmisartan Enhance Anti-Atherosclerotic Potency for Advanced Atherosclerosis in ApoE-/- Mice. ( 30480514 )
2019
9
Hyaluronic Acid-Functionalized Gadolinium Doped Iron Oxide Nanoparticles for Atherosclerosis-Targeted Mr Imaging. ( 30480520 )
2019
10
Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet. ( 30342015 )
2019
11
Evaluation on the effect of hydrogen sulfide on the NLRP3 signaling pathway and its involvement in the pathogenesis of atherosclerosis. ( 30246263 )
2019
12
PCSK9: A novel inflammation modulator in atherosclerosis? ( 30246446 )
2019
13
Effects and mechanisms of Danshen-Shanzha herb-pair for atherosclerosis treatment using network pharmacology and experimental pharmacology. ( 30312741 )
2019
14
Borderline Q-waves in individuals without overt cardiovascular disease: Relations with adiposity, subclinical atherosclerosis and vascular stiffness. ( 30195838 )
2019
15
Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis. ( 30107156 )
2019
16
Critical roles of inflammation in atherosclerosis. ( 29907363 )
2019
17
The Growing Field of Imaging of Atherosclerosis in Peripheral Arteries. ( 29783854 )
2019
18
Preclinical markers of atherosclerosis in acromegaly: a systematic review and meta-analysis. ( 30225826 )
2018
19
Left atrial myxoma and concomittant acute myocardial infarction due to coronary atherosclerosis. ( 30306631 )
2018
20
Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis. ( 30185234 )
2018
21
Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β2-microglobulin-related amyloidosis and indoxyl sulfate-induced atherosclerosis-Oshima Award Address 2016. ( 29869756 )
2018
22
The Extent of Aortic Atherosclerosis Predicts the Occurrence, Severity, and Recovery of Acute Kidney Injury After Transcatheter Aortic Valve Replacement. ( 30354779 )
2018
23
Corrigendum to "The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness" [Int. J. Cardiol. 227 (2017) 938-949]. ( 30384978 )
2018
24
Association of galectin-3 with markers of myocardial function, atherosclerosis, and vascular fibrosis in patients with rheumatoid arthritis. ( 30353563 )
2018
25
Common atherosclerosis genetic risk factors and subclinical atherosclerosis in rheumatoid arthritis: the relevance of disease duration. ( 30374689 )
2018
26
Corrigendum to "Vascular brain-derived neurotrophic factor pathway in rats with adjuvant-induced arthritis: Effect of anti-rheumatic drugs" [Atherosclerosis 274 (July 2018) 77-85]. ( 30301567 )
2018
27
Atherosclerosis in Rheumatoid Arthritis: Promoters and Opponents. ( 30259381 )
2018
28
Total body proteoglycan 4 (Prg4) deficiency increases atherosclerosis susceptibility in apolipoprotein E knockout and low-density lipoprotein receptor knockout mice. ( 30477757 )
2018
29
Relation of the CHA2DS2-VASc Score to Risk of Thrombotic and Embolic Stroke in Community-Dwelling Individuals Without Atrial Fibrillation (From The Atherosclerosis Risk in Communities [ARIC] Study). ( 30527796 )
2018
30
Television Watching as Sedentary Behavior and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study. ( 30463480 )
2018
31
The epicardial adipose inflammatory triad: coronary atherosclerosis, atrial fibrillation, and heart failure with a preserved ejection fraction. ( 30225884 )
2018
32
Role of the CHADS2 Score in the Evaluation of Carotid Atherosclerosis in Patients with Atrial Fibrillation Undergoing Carotid Artery Ultrasonography. ( 30211222 )
2018
33
The Association of Fibroblast Growth Factor 23 with Arterial Stiffness and Atherosclerosis in Patients with Autosomal Dominant Polycystic Kidney Disease. ( 30064143 )
2018
34
Plasma miR-126 and miR-143 as Potential Novel Biomarkers for Cerebral Atherosclerosis. ( 30309729 )
2018
35
Intracranial Arterial Calcificationes Can Reflect Cerebral Atherosclerosis Burden. ( 30375758 )
2018
36
The Impact of Cerebral Atherosclerosis According to Location on Prognosis after Coronary Artery Bypass Grafting. ( 30408800 )
2018
37
Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice. ( 30292879 )
2018
38
Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100only/LDLR-/- Mouse Strain. ( 29770337 )
2018
39
Atherosclerosis of the right posterior hepatic artery in a patient with hilar cholangiocarcinoma undergoing left trisectionectomy: a case report of a therapeutic pitfall. ( 30249240 )
2018
40
Long-term prognosis of unheralded myocardial infarction vs chronic angina; role of sex and coronary atherosclerosis burden. ( 30064378 )
2018
41
Cardiovascular disease in chronic myelomonocytic leukemia: do monocytosis and chronic inflammation predispose to accelerated atherosclerosis? ( 30182347 )
2018
42
Case Image: Endovascular coil treatment of a right coronary artery aneurysm related to atherosclerosis. ( 30516535 )
2018
43
Atherosclerosis, Hypertension, and Diabetes in Alzheimer's Disease, Vascular dementia, and Mixed Dementia: Prevalence and Presentation. ( 30507582 )
2018
44
Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study. ( 30439332 )
2018
45
Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis. ( 30333009 )
2018
46
Atherosclerosis, Hypertension, and Diabetes in Alzheimer's Disease, Vascular Dementia, and Mixed Dementia: Prevalence and Presentation. ( 30149459 )
2018
47
The introduction of refined carbohydrates in the Alaskan Inland Inuit diet may have led to an increase in dental caries, hypertension and atherosclerosis. ( 30018773 )
2018
48
Association Between Folic Acid Supplementation and Retinal Atherosclerosis in Chinese Adults With Hypertension Complicated by Diabetes Mellitus. ( 30425639 )
2018
49
New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. ( 30384259 )
2018
50
Serum Uric Acid Levels in Type 2 Diabetes Mellitus: Is There a Linear Relationship with Severity of Carotid Atherosclerosis? ( 30294580 )
2018

Variations for Atherosclerosis Susceptibility

ClinVar genetic disease variations for Atherosclerosis Susceptibility:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 VEGFA NM_001025366.2(VEGFA): c.-2055A> C single nucleotide variant Benign rs699947 GRCh37 Chromosome 6, 43736389: 43736389
2 VEGFA NM_001025366.2(VEGFA): c.-2055A> C single nucleotide variant Benign rs699947 GRCh38 Chromosome 6, 43768652: 43768652
3 ALOX5 ALOX5, VARIANT PROMOTER SP1 BINDING undetermined variant drug response,risk factor
4 ESR1 ESR1, IVS1, T-C, -401 single nucleotide variant drug response,risk factor

Copy number variations for Atherosclerosis Susceptibility from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 207754 6 160900000 164400000 Gain LPA Atherosclerosis

Expression for Atherosclerosis Susceptibility

Search GEO for disease gene expression data for Atherosclerosis Susceptibility.

Pathways for Atherosclerosis Susceptibility

GO Terms for Atherosclerosis Susceptibility

Cellular components related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.63 APOA1 APOB APOE LDLR TLR4 VCAM1
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.61 APOB APOE LDLR
3 high-density lipoprotein particle GO:0034364 9.58 APOA1 APOE PON1
4 very-low-density lipoprotein particle GO:0034361 9.54 APOA1 APOB APOE
5 endocytic vesicle lumen GO:0071682 9.5 APOA1 APOB APOE
6 spherical high-density lipoprotein particle GO:0034366 9.48 APOA1 PON1
7 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
8 chylomicron GO:0042627 9.43 APOA1 APOB APOE
9 intermediate-density lipoprotein particle GO:0034363 9.13 APOA1 APOB APOE
10 low-density lipoprotein particle GO:0034362 8.92 APOA1 APOB APOE LDLR
11 extracellular space GO:0005615 10.1 ALOX5 APOA1 APOB APOE CCL2 CRP

Biological processes related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.93 APOE CDKN2B-AS1 ESR1 LDLR
2 receptor-mediated endocytosis GO:0006898 9.91 APOA1 APOB APOE LDLR
3 lipid transport GO:0006869 9.85 APOA1 APOB APOE LDLR
4 steroid metabolic process GO:0008202 9.84 APOA1 APOB APOE LDLR
5 cholesterol homeostasis GO:0042632 9.76 APOA1 APOB APOE LDLR
6 retinoid metabolic process GO:0001523 9.75 APOA1 APOB APOE
7 cholesterol transport GO:0030301 9.7 APOA1 APOB LDLR
8 triglyceride catabolic process GO:0019433 9.69 APOA1 APOB APOE
9 reverse cholesterol transport GO:0043691 9.67 APOA1 APOE
10 high-density lipoprotein particle remodeling GO:0034375 9.67 APOA1 APOE
11 positive regulation of lipid biosynthetic process GO:0046889 9.67 APOA1 APOE
12 lipoxygenase pathway GO:0019372 9.66 ALOX5 PON1
13 positive regulation of cholesterol efflux GO:0010875 9.66 APOE PON1
14 low-density lipoprotein particle remodeling GO:0034374 9.65 APOB APOE
15 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 CCL2 TLR4
16 regulation of cholesterol metabolic process GO:0090181 9.65 APOE LDLR
17 cholesterol efflux GO:0033344 9.65 APOA1 APOB APOE
18 high-density lipoprotein particle assembly GO:0034380 9.64 APOA1 APOE
19 phospholipid efflux GO:0033700 9.63 APOA1 APOE
20 regulation of protein metabolic process GO:0051246 9.62 APOE LDLR
21 positive regulation of cholesterol esterification GO:0010873 9.62 APOA1 APOE
22 very-low-density lipoprotein particle remodeling GO:0034372 9.61 APOA1 APOE
23 chylomicron assembly GO:0034378 9.61 APOA1 APOB APOE
24 regulation of Cdc42 protein signal transduction GO:0032489 9.59 APOA1 APOE
25 regulation of cholesterol transport GO:0032374 9.58 APOA1 APOE
26 high-density lipoprotein particle clearance GO:0034384 9.58 APOA1 APOE LDLR
27 cholesterol import GO:0070508 9.57 APOA1 LDLR
28 very-low-density lipoprotein particle clearance GO:0034447 9.56 APOB APOE
29 cholesterol metabolic process GO:0008203 9.55 APOA1 APOB APOE LDLR PON1
30 chylomicron remnant clearance GO:0034382 9.54 APOB APOE LDLR
31 chylomicron remodeling GO:0034371 9.5 APOA1 APOB APOE
32 response to caloric restriction GO:0061771 9.49 APOE LDLR
33 lipoprotein biosynthetic process GO:0042158 9.43 APOA1 APOB APOE
34 lipoprotein metabolic process GO:0042157 9.26 APOA1 APOB APOE LDLR
35 lipoprotein catabolic process GO:0042159 8.8 APOB APOE LDLR
36 lipid metabolic process GO:0006629 10.04 APOA1 APOB APOE LDLR PON1
37 positive regulation of gene expression GO:0010628 10 APOB CDKN2B-AS1 CRP LDLR TLR4

Molecular functions related to Atherosclerosis Susceptibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.76 APOA1 APOB APOE ESR1
2 amyloid-beta binding GO:0001540 9.58 APOA1 APOE LDLR
3 phospholipid binding GO:0005543 9.46 APOA1 APOB APOE PON1
4 low-density lipoprotein particle binding GO:0030169 9.43 CRP LDLR
5 lipid transporter activity GO:0005319 9.43 APOA1 APOB APOE
6 lipoprotein particle binding GO:0071813 9.37 APOA1 APOE
7 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.32 APOA1 APOE
8 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CRP
9 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE

Sources for Atherosclerosis Susceptibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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