MedlinePlus
:
43
Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body.
Atherosclerosis can lead to serious problems, including
Coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack.
Carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke.
Peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections.
Atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have it until they have a medical emergency.
A physical exam, imaging, and other diagnostic tests can tell if you have it. Medicines can slow the progress of plaque buildup. Your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress.
NIH: National Heart, Lung, and Blood Institute
MalaCards based summary
:
Atherosclerosis Susceptibility, also known as
atherosclerosis, is related to
cerebral atherosclerosis and
peripheral vascular disease, and has symptoms including
angina pectoris,
chest pain and
edema. An important gene associated with Atherosclerosis Susceptibility is
CDKN2B-AS1 (CDKN2B Antisense RNA 1
abundantly expressed in atherosclerotic lesions.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are
Metabolism of fat-soluble vitamins and
Interleukin-4 and 13 signaling. The drugs
insulin and
Insulin, Globin Zinc have been mentioned in the context of this disorder. Affiliated tissues include
Endothelium and
Heart, and related phenotypes are
myocardial infarction and
hypertriglyceridemia
OMIM
:
57
The atherogenic lipoprotein phenotype (ALP) is a common heritable trait characterized by a preponderance of small, dense low density lipoprotein (LDL) particles (subclass pattern B), increased levels of triglyceride-rich lipoproteins, reduction in high density lipoprotein, and a 3-fold increased risk of myocardial infarction (summary by Nishina et al., 1992).
The so-called atherogenic lipoprotein phenotype was shown by Austin et al. (1988) to be independently associated with an increased risk for coronary artery disease. Allayee et al. (1998) concluded, furthermore, that there is a genetically based association between familial combined hyperlipidemia (FCHL; 144250) and small, dense LDL particles and that the genetic determinants for LDL particle size are shared, at least in part, among FCHL families and the more general population at risk for coronary artery disease. Juo et al. (1998) concluded from a bivariate segregation analysis of small, dense LDL particles and elevated apolipoprotein B levels (APOB; 107730), which are commonly found together in members of FCHL families, that the 2 traits share a common major gene plus individual polygenic components. The common major gene was estimated to explain 37% of the variance of adjusted LDL particle size and 23% of the variance of adjusted apoB levels.
(108725)
PubMed Health
:
63
About atherosclerosis: Atherosclerosis (ath-er-o-skler-O-sis) is a disease in which
plaque (plak) builds up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts
of your body.Plaque is made up of fat, cholesterol, calcium, and other
substances found in the blood. Over time, plaque hardens and
narrows your arteries. This limits the flow of oxygen-rich blood to
your organs and other parts of your body.Atherosclerosis can lead to serious problems, including heart attack,
stroke, or even
death.
Wikipedia
:
76
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque....
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