MCID: ATP013
MIFTS: 41

Atopic Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

MalaCards integrated aliases for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 58 70

Characteristics:

Orphanet epidemiological data:

58
atopic keratoconjunctivitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 H16.2
UMLS via Orphanet 71 C1274788
Orphanet 58 ORPHA163934
UMLS 70 C1274788

Summaries for Atopic Keratoconjunctivitis

MalaCards based summary : Atopic Keratoconjunctivitis is related to blepharitis and pemphigoid. An important gene associated with Atopic Keratoconjunctivitis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and skin, and related phenotypes are corneal opacity and dry skin

Related Diseases for Atopic Keratoconjunctivitis

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 blepharitis 30.4 MUC5AC MUC16 IL4
2 pemphigoid 30.3 IL5 IL4 IFNG
3 vernal keratoconjunctivitis 30.3 RNASE3 IL5 IL4 IGHE
4 eye disease 30.2 MUC5AC IL5 IL4 IL2 IFNG
5 thyroiditis 30.1 IL4 IL2 IFNG
6 alopecia areata 30.1 IL4 IL2 IFNG
7 alopecia 30.1 IL4 IL2 IFNG
8 keratoconjunctivitis sicca 30.0 MUC5AC IL4
9 erythema multiforme 29.9 IL5 IL4 IL2 IFNG
10 autoimmune disease 29.9 IL5 IL4 IL2 IFNG
11 ige responsiveness, atopic 29.9 RNASE3 IL5 IL4 IGHE IFNG
12 keratoconjunctivitis 29.8 RNASE3 MUC5AC MUC16 IL5 IL4 IL3
13 allergic conjunctivitis 29.8 RNASE3 IL5 IL4 IL2 IGHE IFNG
14 hyper ige syndrome 29.6 RNASE3 IL4 IGHE IFNG
15 ocular cicatricial pemphigoid 29.5 RNASE3 PRG2 IL4
16 conjunctival disease 29.5 RNASE3 MUC5AC IL5 IL4 IL2 IFNG
17 dermatitis 29.5 RNASE3 IL5 IL4 IL2 IGHE IFNG
18 conjunctivitis 29.5 RNASE3 MUC16 IL5 IL4 IL2 IGHE
19 proteasome-associated autoinflammatory syndrome 1 29.3 RNASE3 IL5 IL4 IGHE IFNG
20 chronic conjunctivitis 29.3 RNASE3 MUC5AC IL5 IL4 IGHE
21 dermatitis, atopic 29.2 RNASE3 PRG2 IL5 IL4 IL2 IGHE
22 pollen allergy 28.7 RNASE3 PRG2 IL5 IL3 IGHE
23 rhinitis 28.7 RNASE3 PRG2 IL5 IL4 IGHE IFNG
24 allergic disease 28.2 RNASE3 PRG2 IL5 IL4 IL3 IL2
25 keratitis, hereditary 10.5
26 keratoconus 10.4
27 keratopathy 10.3
28 corneal ulcer 10.3
29 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.3 IL4 IL2
30 fixed drug eruption 10.3 IL2 IFNG
31 skin sarcoidosis 10.3 IL2 IFNG
32 eosinophilic fasciitis 10.3 IL5 IFNG
33 virus associated hemophagocytic syndrome 10.3 IL4 IL2
34 oral tuberculosis 10.3 IL2 IFNG
35 aztreonam allergy 10.3 IL5 IL2
36 jak3-deficient severe combined immunodeficiency 10.3 IL4 IL2
37 metal allergy 10.3 IL4 IL2
38 orofacial granulomatosis 10.3 IL4 IFNG
39 berylliosis 10.3 IL2 IFNG
40 eales disease 10.3 IL4 IFNG
41 retinitis pigmentosa 46 10.3 IL4 IFNG
42 scleral disease 10.3 IL2 IFNG
43 ifap syndrome 2 10.3
44 cow milk allergy 10.3 IL5 IL4
45 tungiasis 10.3 IL4 IFNG
46 chronic active epstein-barr virus infection 10.3 IL2 IFNG
47 loiasis 10.3 IL5 IL4
48 mikulicz disease 10.3 IL5 IL4
49 chorioretinitis 10.3 IL2 IFNG
50 tuberculoid leprosy 10.2 IL2 IFNG

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to Atopic Keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

Human phenotypes related to Atopic Keratoconjunctivitis:

58 31 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 corneal opacity 58 31 hallmark (90%) Very frequent (99-80%) HP:0007957
2 dry skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0000958
3 keratoconjunctivitis sicca 58 31 hallmark (90%) Very frequent (99-80%) HP:0001097
4 corneal neovascularization 58 31 frequent (33%) Frequent (79-30%) HP:0011496
5 blepharitis 58 31 frequent (33%) Frequent (79-30%) HP:0000498
6 loss of eyelashes 58 31 frequent (33%) Frequent (79-30%) HP:0011457
7 chemosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012375
8 abnormality of the eyelid 58 Frequent (79-30%)
9 keratitis 58 Very frequent (99-80%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
3 Pharmaceutical Solutions Phase 3
4 Ophthalmic Solutions Phase 3
5 Immunosuppressive Agents Phase 3
6 Antirheumatic Agents Phase 3
7 Antifungal Agents Phase 3
8 Cyclosporins Phase 3
9 Calcineurin Inhibitors Phase 3
10 Anti-Infective Agents Phase 3
11 Immunologic Factors Phase 3
12 Dermatologic Agents Phase 3
13 Immunoglobulins Phase 2
14 Antibodies Phase 2
15 Antibodies, Monoclonal Phase 2
16 Immunoglobulin G Phase 1
17 Immunoglobulins, Intravenous Phase 1
18
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis Completed NCT00884585 Phase 3 Cyclosporine Vehicle;Cyclosporine 0.010%
2 A Multi-Center, Double-Masked, Randomized, Placebo-Controlled, Parallel-Group Study Evaluating the Efficacy, Safety, and Tolerability of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC) Recruiting NCT04296864 Phase 2 Dupilumab
3 Topical rVA576 for Treatment of Atopic Keratoconjunctivitis: a Randomised Placebo-controlled Double Masked Parallel Trial (TRACKER) Terminated NCT04037891 Phase 1, Phase 2 rVA576
4 A Phase 1b, Open-Label, Multiple Dose, Proof-of-Concept Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Completed NCT03379311 Phase 1 AK002
5 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Steroid Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Unknown status NCT03557203
6 Long-term Results of Topical Cyclosporine 0.05% in the Treatment of Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

40
Eye, Lung, Skin, T Cells, Bone Marrow, Endothelial, Neutrophil

Publications for Atopic Keratoconjunctivitis

Articles related to Atopic Keratoconjunctivitis:

(show top 50) (show all 324)
# Title Authors PMID Year
1
Pulsed oral corticosteroids for the treatment of vernal and atopic keratoconjunctivitis: a management plan. 61
32612172 2021
2
Tear N-glycomics in vernal and atopic keratoconjunctivitis. 61
33583051 2021
3
Long-term outcomes of 0.1% tacrolimus eye drops in eyes with severe allergic conjunctival diseases. 61
33522964 2021
4
Association between atopic keratoconjunctivitis and the risk of keratoconus. 61
32567209 2021
5
Current Knowledge in Allergic Conjunctivitis. 61
33631915 2021
6
A polymeric aqueous tacrolimus formulation for topical ocular delivery. 61
33571621 2021
7
Dupilumab-associated ocular surface disease: presentation, management and long-term sequelae. 61
33504973 2021
8
Ocular surface disease associated with dupilumab treatment for atopic diseases. 61
32439390 2021
9
IL-1α antibody inhibits dose-dependent exacerbation of eosinophilic inflammation by crude house-dust-mite antigen in the conjunctiva of an atopic keratoconjunctivitis mouse model. 61
33428487 2021
10
Reduced steroid-induced intraocular pressure elevation in tacrolimus-treated refractory allergic ocular diseases. 61
33026594 2020
11
Pharmacotherapeutic management of atopic keratoconjunctivitis. 61
32602382 2020
12
Systemic interventions for severe atopic and vernal keratoconjunctivitis in children and young people up to the age of 16 years. 61
33084033 2020
13
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases. 61
32563624 2020
14
Association between atopic keratoconjunctivitis and the risk of corneal ulcer. 61
33011686 2020
15
Prospective Clinical Study of Keratoconus Progression in Patients Awaiting Corneal Cross-linking. 61
32482959 2020
16
Recognition of Atopic Keratoconjunctivitis During Treatment with Dupilumab for Atopic Dermatitis. 61
32956738 2020
17
Conjunctival Injection Reduction in Patients with Atopic Keratoconjunctivitis Due to Synergic Effect of Bovine Enteric-Coated Lactoferrin in 0.1% Tacrolimus Ophthalmic Suspension. 61
32992801 2020
18
The role of human immunodeficiency virus in the pathogenesis of vernal keratoconjunctivitis-like disease in adults: A demographic and epidemiological study. 61
32709773 2020
19
The prevalence of keratoconus in children with allergic eye disease in an Egyptian population. 61
32659124 2020
20
Japanese guidelines for allergic conjunctival diseases 2020. 61
33211650 2020
21
Dupilumab-induced ocular surface disease (DIOSD) in patients with atopic dermatitis: clinical presentation, risk factors for development and outcomes of treatment with tacrolimus ointment. 61
31554632 2020
22
Dupilumab therapy in a patient with atopic dermatitis and severe atopic keratoconjunctivitis. 61
32031716 2020
23
Potential Biomarkers for Allergic Conjunctival Diseases. 61
32097185 2020
24
Amelioration of conjunctival giant papillae by dupilumab in patients with atopic keratoconjunctivitis. 61
31678297 2020
25
Combination of Two Rapid Ophthalmic Test Kits for Improved Diagnosis in Cases of Severe Binocular Conjunctivitis. 61
32079333 2020
26
Clinical characteristics and outcomes of ocular allergy in Thai children. 61
32061246 2020
27
Air pollution significantly associated with severe ocular allergic inflammatory diseases. 61
31796815 2019
28
Neurotrophic factors and nerve growth factor in ocular allergy. 61
31145195 2019
29
Topical tacrolimus for allergic eye diseases. 61
31169598 2019
30
Recent trends of ocular complications in patients with atopic dermatitis. 61
31243592 2019
31
Atopic Keratoconjunctivitis: Pharmacotherapy for the Elderly. 61
31055787 2019
32
Diagnosing and managing allergic conjunctivitis in childhood: The allergist's perspective. 61
30742722 2019
33
[Tacrolimus ointment in the management of atopic keratoconjunctivitis]. 61
30935698 2019
34
Tacrolimus ointment in the management of atopic keratoconjunctivitis. 61
30851973 2019
35
The efficacy of 0.1% tacrolimus ophthalmic suspension in the treatment of severe atopic keratoconjunctivitis. 61
30639466 2019
36
Management of advanced ocular surface disease in patients with severe atopic keratoconjunctivitis. 61
30528292 2019
37
Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing. 61
30471305 2019
38
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
39
Immunopathological Features of Severe Chronic Atopic Keratoconjunctivitis and Effects of Topical Cyclosporine Treatment. 61
30189151 2019
40
Topical Treatment of Persistent Epithelial Defects with a Matrix Regenerating Agent. 61
30312119 2018
41
Ocular involvement in atopic disease: a review. 61
30222657 2018
42
[Erratum to "Atopic keratoconjunctivitis: One allergy may mask another. A clinical observation with two types of hypersensitivity reactions: IgE-mediated and non-IgE-mediated" J Fr Ophtalmol 2018;41:224-30]. 61
30269972 2018
43
Preclinical characterization and clinical evaluation of tacrolimus eye drops. 61
29705214 2018
44
Seeing is believing: A review of apheresis therapy in the treatment of ophthalmologic disease. 61
29150864 2018
45
Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review. 61
29610174 2018
46
Atopic keratoconjunctivitis: A diagnostic dilemma-a case report. 61
29668589 2018
47
[Atopic keratoconjunctivitis: One allergy may mask another. A clinical observation with two types of hypersensitivity reactions: IgE-mediated and non-IgE-mediated]. 61
29567021 2018
48
Clinical Severity and Tear Biomarkers, Eosinophil Cationic Protein and CCL23, in Chronic Allergic Conjunctival Diseases. 61
27929738 2018
49
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. 61
27901637 2018
50
Allergic conjunctivitis: current concepts on pathogenesis and management. 61
29552874 2018

Variations for Atopic Keratoconjunctivitis

Expression for Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for Atopic Keratoconjunctivitis

Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 RNASE3 PRG2 MUC5AC MUC16 IL5 IL4
2
Show member pathways
13.37 IL5 IL4 IL3 IL2 IFNG CCL22
3
Show member pathways
13.19 IL5 IL4 IL3 IL2 IGHE IFNG
4
Show member pathways
13.12 IL5 IL4 IL3 IL2 CCL22
5 12.68 IL5 IL4 IL3 IL2 IFNG
6
Show member pathways
12.61 RNASE3 PRG2 IL5 IL4 IL3 IL2
7
Show member pathways
12.5 IL4 IL2 IGHE IFNG
8
Show member pathways
12.46 IL5 IL4 IL2 IFNG
9
Show member pathways
12.45 IL5 IL4 IL2 IFNG
10
Show member pathways
12.43 IL5 IL4 IL3 IGHE
11 12.41 IL4 IL3 IL2 IFNG
12
Show member pathways
12.36 IL4 IL3 IL2 IFNG
13
Show member pathways
12.29 IL5 IL4 IL3 IL2 IFNG
14
Show member pathways
12.2 MUC5AC IL5 IL4 IFNG
15
Show member pathways
12.17 IL4 IL2 IFNG
16
Show member pathways
12.13 IL5 IL4 IL3 IL2 IFNG
17
Show member pathways
12.01 IL5 IL3 IL2
18 11.89 IL4 IL2 IFNG
19 11.87 IL4 IGHE CCL22
20
Show member pathways
11.86 IL4 IL2 IFNG
21 11.83 IL5 IL4 IL3 IL2 IFNG
22 11.78 IL5 IL4 IL3
23 11.69 IL5 IL4 IL2 IFNG
24 11.66 IL5 IL4 IL2 IFNG
25 11.55 IL5 IL4 IGHE
26
Show member pathways
11.43 IL5 IL4 IL3 IL2 IFNG
27 11.25 IL5 IL4 IL2 IFNG
28 11.23 IL5 IL4 IFNG
29 11.11 IL2 IFNG
30 11.02 IL5 IL4 IL2 IFNG CCL22
31 10.97 IL5 IL4 IL2 IFNG
32 10.89 PRG2 IL5 IL4 IL3 IL2 CCL22
33 10.7 IL5 IL4
34 10.48 IL5 IL4 IL3 IL2 IFNG

GO Terms for Atopic Keratoconjunctivitis

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 RNASE3 MUC5AC MUC16 IL5 IL4 IL3
2 extracellular region GO:0005576 9.36 RNASE3 PRG2 MUC5AC MUC16 IL5 IL4

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 IL5 IL4 IL3 IL2 IFNG
2 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.56 IL4 IL2
3 microglial cell activation GO:0001774 9.55 IL4 IFNG
4 innate immune response in mucosa GO:0002227 9.54 RNASE3 IL4
5 positive regulation of T cell differentiation GO:0045582 9.52 IL4 IL2
6 positive regulation of immunoglobulin production GO:0002639 9.51 IL5 IL2
7 regulation of regulatory T cell differentiation GO:0045589 9.49 IL2 IFNG
8 positive regulation of MHC class II biosynthetic process GO:0045348 9.48 IL4 IFNG
9 negative regulation of T-helper 17 cell differentiation GO:2000320 9.46 IL4 IL2
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 IL4 IL3 IL2 IFNG
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IL4 IL2
12 positive regulation of B cell proliferation GO:0030890 9.43 IL5 IL4 IL2
13 cytokine-mediated signaling pathway GO:0019221 9.43 IL5 IL4 IL3 IL2 IGHE CCL22
14 positive regulation of cellular respiration GO:1901857 9.4 IL4 IFNG
15 neuroinflammatory response GO:0150076 9.37 IL4 IFNG
16 immune response GO:0006955 9.23 PRG2 IL5 IL4 IL3 IL2 IGHE

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL5 IL4 IL3 IL2
2 cytokine activity GO:0005125 9.1 IL5 IL4 IL3 IL2 IFNG CCL22

Sources for Atopic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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