MCID: ATP013
MIFTS: 44

Atopic Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

MalaCards integrated aliases for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 60 74

Characteristics:

Orphanet epidemiological data:

60
atopic keratoconjunctivitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

ICD10 via Orphanet 35 H16.2
UMLS via Orphanet 75 C1274788
Orphanet 60 ORPHA163934
UMLS 74 C1274788

Summaries for Atopic Keratoconjunctivitis

MalaCards based summary : Atopic Keratoconjunctivitis is related to keratoconjunctivitis and vernal keratoconjunctivitis. An important gene associated with Atopic Keratoconjunctivitis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Miconazole and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related phenotypes are corneal opacity and dry skin

Related Diseases for Atopic Keratoconjunctivitis

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 30.7 IFNG IL2 IL3 IL4 IL5 RNASE3
2 vernal keratoconjunctivitis 30.4 IL4 IL5 RNASE3
3 ocular cicatricial pemphigoid 29.9 IL4 PRG2 RNASE3
4 allergic conjunctivitis 29.9 IFNG IL4 IL5 RNASE3
5 dermatitis 29.8 CCL22 IFNG IGHE IL4 IL5
6 conjunctivitis 29.2 IFNG IL2 IL4 IL5 MUC16 RNASE3
7 dermatitis, atopic 28.9 CCL22 IFNG IGHE IL2 IL4 IL5
8 hyperlucent lung 10.4 IFNG IL4
9 eosinophilic fasciitis 10.4 IFNG IL5
10 cephalosporin allergy 10.4 IFNG IL5
11 baylisascariasis 10.4 IFNG IL4
12 penicillin allergy 10.4 IFNG IL4
13 crustacean allergy 10.4 IFNG IL4
14 variola major 10.4 IFNG IL2
15 fixed drug eruption 10.4 IFNG IL2
16 berylliosis 10.4 IFNG IL2
17 virus associated hemophagocytic syndrome 10.4 IL2 IL4
18 eosinophilia-myalgia syndrome 10.4 IFNG IL5
19 sulfamethoxazole allergy 10.4 IL4 IL5
20 strongyloidiasis 10.4 IFNG IL5
21 autoimmune vasculitis 10.4 IL2 IL4
22 trichinosis 10.3 IL4 IL5
23 jak3-deficient severe combined immunodeficiency 10.3 IL2 IL4
24 non-suppurative otitis media 10.3 IL4 IL5
25 clonorchiasis 10.3 IFNG IL2
26 multicentric castleman disease 10.3 IFNG IL5
27 seborrheic infantile dermatitis 10.3 IL3 IL5
28 eosinophilic meningitis 10.3 IL4 IL5
29 crohn's colitis 10.3 IFNG IL2
30 intestinal schistosomiasis 10.3 IL4 IL5
31 chronic tic disorder 10.3 IL4 IL5
32 orofacial granulomatosis 10.3 IFNG IL4
33 filarial elephantiasis 10.3 IL4 IL5
34 buruli ulcer 10.3 IFNG IL4
35 autoimmune gastritis 10.3 IL2 IL4
36 hypereosinophilic syndrome, idiopathic 10.3 IL3 IL5
37 primary systemic mycosis 10.3 IFNG IL4
38 chronic active epstein-barr virus infection 10.3 IFNG IL2
39 mycoplasma pneumoniae pneumonia 10.3 IFNG IL4
40 intermediate uveitis 10.3 IFNG IL2
41 necatoriasis 10.3 CCL22 IL5
42 poliomyelitis 10.3 IFNG IL4
43 eales disease 10.3 IFNG IL4
44 vulvovaginal candidiasis 10.3 IL2 IL4
45 cyclic neutropenia 10.3 IFNG IL3
46 posterior uveitis 10.3 IFNG IL2
47 miliary tuberculosis 10.3 IFNG MUC16
48 lichen disease 10.3 IFNG IL4
49 opisthorchiasis 10.3 IL4 MUC16
50 blepharoconjunctivitis 10.2 IL4 RNASE3

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to Atopic Keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

Human phenotypes related to Atopic Keratoconjunctivitis:

60 33 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 corneal opacity 60 33 hallmark (90%) Very frequent (99-80%) HP:0007957
2 dry skin 60 33 hallmark (90%) Very frequent (99-80%) HP:0000958
3 keratoconjunctivitis sicca 60 33 hallmark (90%) Very frequent (99-80%) HP:0001097
4 blepharitis 60 33 frequent (33%) Frequent (79-30%) HP:0000498
5 loss of eyelashes 60 33 frequent (33%) Frequent (79-30%) HP:0011457
6 corneal neovascularization 60 33 frequent (33%) Frequent (79-30%) HP:0011496
7 chemosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012375
8 keratitis 60 Very frequent (99-80%)
9 abnormality of the eyelid 60 Frequent (79-30%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
2 Anti-Infective Agents Phase 3,Not Applicable
3 Ophthalmic Solutions Phase 3,Not Applicable
4 Immunosuppressive Agents Phase 3,Not Applicable
5 Immunologic Factors Phase 3,Not Applicable
6 Cyclosporins Phase 3,Not Applicable
7 Antifungal Agents Phase 3,Not Applicable
8 Dermatologic Agents Phase 3,Not Applicable
9 Antirheumatic Agents Phase 3,Not Applicable
10 Calcineurin Inhibitors Phase 3,Not Applicable
11 Pharmaceutical Solutions Phase 3,Not Applicable
12 Antibodies Phase 1
13 Immunoglobulin G Phase 1
14 Antibodies, Monoclonal Phase 1
15 Immunoglobulins Phase 1
16
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis Completed NCT00884585 Phase 3 Cyclosporine Vehicle;Cyclosporine 0.010%
2 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Active, not recruiting NCT03379311 Phase 1 AK002
3 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
4 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Recruiting NCT03557203

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

42
Eye, Skin, Bone, Bone Marrow, T Cells

Publications for Atopic Keratoconjunctivitis

Articles related to Atopic Keratoconjunctivitis:

(show top 50) (show all 98)
# Title Authors Year
1
The efficacy of 0.1% tacrolimus ophthalmic suspension in the treatment of severe atopic keratoconjunctivitis. ( 30639466 )
2019
2
Tacrolimus ointment in the management of atopic keratoconjunctivitis. ( 30851973 )
2019
3
Atopic keratoconjunctivitis: A diagnostic dilemma-a case report. ( 29668589 )
2018
4
Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review. ( 29610174 )
2018
5
Immunopathological Features of Severe Chronic Atopic Keratoconjunctivitis and Effects of Topical Cyclosporine Treatment. ( 30189151 )
2018
6
Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing. ( 30471305 )
2018
7
Management of advanced ocular surface disease in patients with severe atopic keratoconjunctivitis. ( 30528292 )
2018
8
Ocular Surface Squamous Neoplasia Associated with Atopic Keratoconjunctivitis. ( 28275599 )
2017
9
Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice. ( 28855579 )
2017
10
Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case. ( 28138334 )
2017
11
Successful Subcutaneous Allergen-Specific Immunotherapy in Refractory Atopic Keratoconjunctivitis: A Case Report. ( 29422859 )
2017
12
Atopic keratoconjunctivitis: long-term results of medical treatment and penetrating keratoplasty. ( 28076564 )
2016
13
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. ( 27901637 )
2016
14
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
15
Atopic keratoconjunctivitis with corneal ulcer. Case report. ( 29450349 )
2016
16
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. ( 26278858 )
2015
17
Involvement of Chemokines and a CD4-Positive T Cell Subset in the Development of Conjunctival Secondary Lymphoid Follicles in an Atopic Keratoconjunctivitis Mouse Model. ( 26302769 )
2015
18
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. ( 25682856 )
2015
19
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. ( 25923050 )
2015
20
Functional visual acuity assessment of severe atopic keratoconjunctivitis. ( 25289719 )
2014
21
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. ( 24439439 )
2014
22
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. ( 25705372 )
2014
23
Central corneal thickness in patients with atopic keratoconjunctivitis. ( 25240805 )
2014
24
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. ( 23949491 )
2013
25
Atopic keratoconjunctivitis. ( 23406935 )
2013
26
Atopic keratoconjunctivitis: A review. ( 24342754 )
2013
27
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. ( 23886231 )
2013
28
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? ( 23106347 )
2013
29
Topical cyclosporine for atopic keratoconjunctivitis. ( 22972132 )
2012
30
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. ( 22581322 )
2012
31
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. ( 22441637 )
2012
32
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. ( 22092652 )
2012
33
Atopic keratoconjunctivitis: present day diagnosis. ( 22872669 )
2012
34
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. ( 22717457 )
2012
35
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. ( 22486642 )
2012
36
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. ( 22378107 )
2012
37
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. ( 22275342 )
2012
38
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. ( 21541276 )
2011
39
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. ( 22606467 )
2011
40
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. ( 20861732 )
2011
41
Omalizumab for severe atopic keratoconjunctivitis. ( 22791726 )
2010
42
Atopic keratoconjunctivitis and atopic dermatitis. ( 20720488 )
2010
43
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. ( 20657166 )
2010
44
Systemic cyclosporin A in severe atopic keratoconjunctivitis. ( 20491051 )
2010
45
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. ( 20482394 )
2010
46
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. ( 18721214 )
2009
47
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). ( 19693288 )
2009
48
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. ( 18782111 )
2008
49
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. ( 18724148 )
2008
50
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. ( 18614131 )
2008

Variations for Atopic Keratoconjunctivitis

Expression for Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for Atopic Keratoconjunctivitis

Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL22 IFNG IGHE IL2 IL3 IL4
2
Show member pathways
13.49 CCL22 IFNG IL2 IL3 IL4 IL5
3
Show member pathways
13.38 CCL22 IFNG IL2 IL3 IL4 IL5
4
Show member pathways
13.22 CCL22 IFNG IGHE IL2 IL3 IL4
5
Show member pathways
13.13 CCL22 IL2 IL3 IL4 IL5
6
Show member pathways
12.72 IFNG IL2 IL3 IL4 IL5 PRG2
7 12.71 IFNG IL2 IL3 IL4 IL5
8
Show member pathways
12.51 IFNG IGHE IL2 IL4
9
Show member pathways
12.47 IFNG IL2 IL4 IL5
10
Show member pathways
12.46 IGHE IL3 IL4 IL5
11 12.43 IFNG IL2 IL3 IL4
12
Show member pathways
12.39 IFNG IL2 IL3 IL4
13
Show member pathways
12.31 IFNG IL2 IL4 IL5
14
Show member pathways
12.31 IFNG IL2 IL3 IL4 IL5
15
Show member pathways
12.22 IFNG IL4 IL5 MUC5AC
16
Show member pathways
12.18 IFNG IL2 IL4
17
Show member pathways
12.17 IFNG IL2 IL3 IL4 IL5
18
Show member pathways
12.02 IL2 IL3 IL5
19
Show member pathways
11.95 CCL22 IFNG IL2 IL3 IL4 IL5
20 11.91 IFNG IL2 IL4
21 11.88 CCL22 IGHE IL4
22
Show member pathways
11.87 IFNG IL2 IL4
23 11.79 IL3 IL4 IL5
24 11.78 IFNG IL2 IL3
25 11.78 IFNG IL2 IL3 IL4 IL5
26 11.74 IFNG IL2 IL4 IL5
27 11.71 IFNG IL2 IL4 IL5
28 11.65 CCL22 IFNG IL2 IL4
29 11.57 IGHE IL4 IL5
30
Show member pathways
11.43 IFNG IL2 IL3 IL4 IL5
31 11.26 IFNG IL4 IL5
32 11.19 IFNG IL2 IL4 IL5
33 11.11 IFNG IL2
34 11.11 CCL22 IL2 IL3 IL4 IL5
35 11.02 CCL22 IFNG IL2 IL4 IL5
36 10.97 IFNG IL2 IL4 IL5
37 10.92 CCL22 IL2 IL3 IL4 IL5 PRG2
38 10.48 IFNG IL2 IL3 IL4 IL5

GO Terms for Atopic Keratoconjunctivitis

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CCL22 IFNG IL2 IL3 IL4 IL5
2 extracellular region GO:0005576 9.36 CCL22 IFNG IGHE IL2 IL3 IL4

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.78 IFNG IL2 IL3 IL5
2 cell-cell signaling GO:0007267 9.69 CCL22 IL2 IL3
3 MAPK cascade GO:0000165 9.67 IL2 IL3 IL5
4 regulation of signaling receptor activity GO:0010469 9.63 CCL22 IFNG IL2 IL3 IL4 IL5
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.56 IFNG IL2 IL3 IL4
6 positive regulation of B cell proliferation GO:0030890 9.5 IL2 IL4 IL5
7 positive regulation of T cell differentiation GO:0045582 9.46 IL2 IL4
8 regulation of regulatory T cell differentiation GO:0045589 9.43 IFNG IL2
9 cytokine-mediated signaling pathway GO:0019221 9.43 CCL22 IGHE IL2 IL3 IL4 IL5
10 positive regulation of immunoglobulin secretion GO:0051024 9.4 IL2 IL5
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.37 IL2 IL4
12 immune response GO:0006955 9.23 CCL22 IFNG IGHE IL2 IL3 IL4

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 IL2 IL3 IL5
2 growth factor activity GO:0008083 9.26 IL2 IL3 IL4 IL5
3 cytokine activity GO:0005125 9.1 CCL22 IFNG IL2 IL3 IL4 IL5

Sources for Atopic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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