MCID: ATP013
MIFTS: 44

Atopic Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

MalaCards integrated aliases for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 59 73

Characteristics:

Orphanet epidemiological data:

59
atopic keratoconjunctivitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA163934
UMLS via Orphanet 74 C1274788
ICD10 via Orphanet 34 H16.2
UMLS 73 C1274788

Summaries for Atopic Keratoconjunctivitis

MalaCards based summary : Atopic Keratoconjunctivitis is related to vernal keratoconjunctivitis and allergic conjunctivitis. An important gene associated with Atopic Keratoconjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Miconazole and Cyclosporins have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and t cells, and related phenotypes are dry skin and keratoconjunctivitis sicca

Related Diseases for Atopic Keratoconjunctivitis

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 vernal keratoconjunctivitis 30.6 IL4 IL5 RNASE3
2 allergic conjunctivitis 29.7 IFNG IL4 IL5 RNASE3
3 keratoconjunctivitis 29.7 IFNG IL2 IL3 IL4 IL5 RNASE3
4 ocular cicatricial pemphigoid 29.3 IL4 PRG2 RNASE3
5 conjunctivitis 28.4 IFNG IL2 IL4 IL5 MUC16 RNASE3
6 dermatitis 28.3 CCL22 IFNG IGHE IL4 IL5 RNASE3
7 dermatitis, atopic 27.6 CCL22 IFNG IGHE IL2 IL4 IL5
8 mycoplasmal pneumonia 10.9 IFNG IL4
9 hyperlucent lung 10.8 IFNG IL4
10 baylisascariasis 10.8 IFNG IL4
11 penicillin allergy 10.8 IFNG IL4
12 eosinophilic fasciitis 10.8 IFNG IL5
13 virus associated hemophagocytic syndrome 10.8 IL2 IL4
14 scleritis 10.8 IL4 IL5
15 variola major 10.8 IFNG IL2
16 trichinosis 10.8 IL4 IL5
17 autoimmune myocarditis 10.8 IFNG IL2
18 jak3-deficient severe combined immunodeficiency 10.8 IL2 IL4
19 non-suppurative otitis media 10.7 IL4 IL5
20 fixed drug eruption 10.7 IFNG IL2
21 strongyloidiasis 10.7 IFNG IL5
22 berylliosis 10.7 IFNG IL2
23 eosinophilia-myalgia syndrome 10.7 IFNG IL5
24 buruli ulcer 10.7 IFNG IL4
25 eosinophilic meningitis 10.7 IL4 IL5
26 cercarial dermatitis 10.7 IL4 IL5
27 intestinal schistosomiasis 10.7 IL4 IL5
28 primary systemic mycosis 10.7 IFNG IL4
29 poliomyelitis 10.7 IFNG IL4
30 clonorchiasis 10.7 IFNG IL2
31 chronic tic disorder 10.7 IL4 IL5
32 crohn's colitis 10.7 IFNG IL2
33 necatoriasis 10.7 CCL22 IL5
34 multicentric castleman disease 10.7 IFNG IL5
35 orofacial granulomatosis 10.7 IFNG IL4
36 primary amebic meningoencephalitis 10.7 IL4 IL5
37 chronic active epstein-barr virus infection 10.7 IFNG IL2
38 eales disease 10.7 IFNG IL4
39 opisthorchiasis 10.6 IL4 MUC16
40 posterior uveitis 10.6 IFNG IL2
41 blepharoconjunctivitis 10.6 IL4 RNASE3
42 intermediate uveitis 10.6 IFNG IL2
43 giant papillary conjunctivitis 10.6 IL4 RNASE3
44 loeffler endocarditis 10.6 IL5 RNASE3
45 lichen disease 10.6 IFNG IL4
46 cow milk allergy 10.6 IL5 RNASE3
47 paragonimiasis 10.6 IL5 RNASE3
48 erythema multiforme 10.6 IFNG IL2
49 tuberculous peritonitis 10.6 IFNG MUC16
50 proliferative glomerulonephritis 10.5 IFNG IL4

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to Atopic Keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

Human phenotypes related to Atopic Keratoconjunctivitis:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0000958
2 keratoconjunctivitis sicca 59 32 hallmark (90%) Very frequent (99-80%) HP:0001097
3 corneal opacity 59 32 hallmark (90%) Very frequent (99-80%) HP:0007957
4 blepharitis 59 32 frequent (33%) Frequent (79-30%) HP:0000498
5 loss of eyelashes 59 32 frequent (33%) Frequent (79-30%) HP:0011457
6 corneal neovascularization 59 32 frequent (33%) Frequent (79-30%) HP:0011496
7 chemosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012375
8 keratitis 59 Very frequent (99-80%)
9 abnormality of the eyelid 59 Frequent (79-30%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
2 Cyclosporins Phase 3,Not Applicable
3 Dermatologic Agents Phase 3,Not Applicable
4 Ophthalmic Solutions Phase 3,Not Applicable
5 Pharmaceutical Solutions Phase 3,Not Applicable
6 Immunosuppressive Agents Phase 3,Not Applicable
7 Anti-Infective Agents Phase 3,Not Applicable
8 Antifungal Agents Phase 3,Not Applicable
9 Antirheumatic Agents Phase 3,Not Applicable
10 Calcineurin Inhibitors Phase 3,Not Applicable
11 Immunoglobulin G Phase 1
12 Antibodies Phase 1
13 Immunoglobulins Phase 1
14 Antibodies, Monoclonal Phase 1
15 Tetrahydrozoline Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis Completed NCT00884585 Phase 3 Cyclosporine Vehicle;Cyclosporine 0.010%
2 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Recruiting NCT03379311 Phase 1 AK002
3 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
4 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Recruiting NCT03557203

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

41
Eye, Skin, T Cells, Bone, Bone Marrow

Publications for Atopic Keratoconjunctivitis

Articles related to Atopic Keratoconjunctivitis:

(show top 50) (show all 92)
# Title Authors Year
1
Atopic keratoconjunctivitis: A diagnostic dilemma-a case report. ( 29668589 )
2018
2
Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review. ( 29610174 )
2018
3
Ocular Surface Squamous Neoplasia Associated with Atopic Keratoconjunctivitis. ( 28275599 )
2017
4
Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice. ( 28855579 )
2017
5
Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case. ( 28138334 )
2017
6
Successful Subcutaneous Allergen-Specific Immunotherapy in Refractory Atopic Keratoconjunctivitis: A Case Report. ( 29422859 )
2017
7
Atopic keratoconjunctivitis: long-term results of medical treatment and penetrating keratoplasty. ( 28076564 )
2016
8
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. ( 27901637 )
2016
9
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
10
Atopic keratoconjunctivitis with corneal ulcer. Case report. ( 29450349 )
2016
11
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. ( 26278858 )
2015
12
Involvement of Chemokines and a CD4-Positive T Cell Subset in the Development of Conjunctival Secondary Lymphoid Follicles in an Atopic Keratoconjunctivitis Mouse Model. ( 26302769 )
2015
13
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. ( 25682856 )
2015
14
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. ( 25923050 )
2015
15
Functional visual acuity assessment of severe atopic keratoconjunctivitis. ( 25289719 )
2014
16
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. ( 24439439 )
2014
17
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. ( 25705372 )
2014
18
Central corneal thickness in patients with atopic keratoconjunctivitis. ( 25240805 )
2014
19
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. ( 23949491 )
2013
20
Atopic keratoconjunctivitis. ( 23406935 )
2013
21
Atopic keratoconjunctivitis: A review. ( 24342754 )
2013
22
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. ( 23886231 )
2013
23
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? ( 23106347 )
2013
24
Topical cyclosporine for atopic keratoconjunctivitis. ( 22972132 )
2012
25
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. ( 22581322 )
2012
26
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. ( 22441637 )
2012
27
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. ( 22092652 )
2012
28
Atopic keratoconjunctivitis: present day diagnosis. ( 22872669 )
2012
29
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. ( 22717457 )
2012
30
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. ( 22486642 )
2012
31
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. ( 22378107 )
2012
32
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. ( 22275342 )
2012
33
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. ( 21541276 )
2011
34
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. ( 22606467 )
2011
35
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. ( 20861732 )
2011
36
Omalizumab for severe atopic keratoconjunctivitis. ( 22791726 )
2010
37
Atopic keratoconjunctivitis and atopic dermatitis. ( 20720488 )
2010
38
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. ( 20657166 )
2010
39
Systemic cyclosporin A in severe atopic keratoconjunctivitis. ( 20491051 )
2010
40
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. ( 20482394 )
2010
41
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. ( 18721214 )
2009
42
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). ( 19693288 )
2009
43
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. ( 18782111 )
2008
44
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. ( 18724148 )
2008
45
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. ( 18614131 )
2008
46
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 18584874 )
2008
47
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. ( 17620070 )
2007
48
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 17768384 )
2007
49
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. ( 17893528 )
2007
50
Clinical grading of atopic keratoconjunctivitis. ( 17873586 )
2007

Variations for Atopic Keratoconjunctivitis

Expression for Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for Atopic Keratoconjunctivitis

Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL22 IFNG IGHE IL2 IL3 IL4
2
Show member pathways
13.33 CCL22 IFNG IL2 IL3 IL4 IL5
3
Show member pathways
13.18 CCL22 IFNG IGHE IL2 IL3 IL4
4
Show member pathways
13.11 CCL22 IL2 IL3 IL4 IL5
5
Show member pathways
12.72 IFNG IL2 IL3 IL4 IL5 PRG2
6 12.67 IFNG IL2 IL3 IL4 IL5
7
Show member pathways
12.5 IFNG IL2 IL3 IL4 IL5
8
Show member pathways
12.44 IGHE IL3 IL4 IL5
9 12.41 IFNG IL2 IL3 IL4
10
Show member pathways
12.37 IFNG IL2 IL3 IL4
11
Show member pathways
12.31 IFNG IL2 IL4 IL5
12
Show member pathways
12.29 IFNG IL2 IL4 IL5
13
Show member pathways
12.19 IFNG IL4 IL5 MUC5AC
14
Show member pathways
12.16 IFNG IL2 IL4
15
Show member pathways
12 IL2 IL3 IL5
16
Show member pathways
11.95 CCL22 IFNG IL2 IL3 IL4 IL5
17 11.89 IFNG IL2 IL4
18 11.86 CCL22 IGHE IL4
19
Show member pathways
11.85 IFNG IL2 IL4
20 11.78 IFNG IL2 IL3 IL4 IL5
21 11.77 IL3 IL4 IL5
22 11.76 IFNG IL2 IL3
23 11.71 IFNG IL2 IL4 IL5
24 11.68 IFNG IL2 IL4 IL5
25 11.54 IGHE IL4 IL5
26
Show member pathways
11.43 IFNG IL2 IL3 IL4 IL5
27 11.22 IFNG IL4 IL5
28 11.19 IFNG IL2 IL4 IL5
29 11.09 IFNG IL2
30 11.02 CCL22 IFNG IL2 IL4 IL5
31 10.97 IFNG IL2 IL4 IL5
32 10.5 IFNG IL2 IL3 IL4 IL5

GO Terms for Atopic Keratoconjunctivitis

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CCL22 IFNG IL2 IL3 IL4 IL5
2 extracellular region GO:0005576 9.36 CCL22 IFNG IGHE IL2 IL3 IL4

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.78 IFNG IL2 IL3 IL5
2 defense response to bacterium GO:0042742 9.67 IGHE PRG2 RNASE3
3 regulation of signaling receptor activity GO:0010469 9.63 CCL22 IFNG IL2 IL3 IL4 IL5
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 IFNG IL2 IL3
5 positive regulation of T cell differentiation GO:0045582 9.46 IL2 IL4
6 regulation of regulatory T cell differentiation GO:0045589 9.43 IFNG IL2
7 positive regulation of B cell proliferation GO:0030890 9.43 IL2 IL4 IL5
8 cytokine-mediated signaling pathway GO:0019221 9.43 CCL22 IGHE IL2 IL3 IL4 IL5
9 positive regulation of immunoglobulin secretion GO:0051024 9.4 IL2 IL5
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.37 IL2 IL4
11 immune response GO:0006955 9.23 CCL22 IFNG IGHE IL2 IL3 IL4

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 IL2 IL3 IL5
2 growth factor activity GO:0008083 9.26 IL2 IL3 IL4 IL5
3 cytokine activity GO:0005125 9.1 CCL22 IFNG IL2 IL3 IL4 IL5

Sources for Atopic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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