MCID: ATP013
MIFTS: 46

Atopic Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

MalaCards integrated aliases for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 59 73

Characteristics:

Orphanet epidemiological data:

59
atopic keratoconjunctivitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA163934
UMLS via Orphanet 74 C1274788
ICD10 via Orphanet 34 H16.2
UMLS 73 C1274788

Summaries for Atopic Keratoconjunctivitis

MalaCards based summary : Atopic Keratoconjunctivitis is related to keratoconjunctivitis and vernal keratoconjunctivitis. An important gene associated with Atopic Keratoconjunctivitis is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Miconazole and Calcineurin Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related phenotypes are corneal opacity and dry skin

Related Diseases for Atopic Keratoconjunctivitis

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 30.9 IFNG IL2 IL3 IL4 IL5 RNASE3
2 vernal keratoconjunctivitis 30.4 IL4 IL5 RNASE3
3 dermatitis 29.9 CCL22 IFNG IGHE IL4 IL5
4 ocular cicatricial pemphigoid 29.9 IL4 PRG2 RNASE3
5 allergic conjunctivitis 29.8 IFNG IL4 IL5 RNASE3
6 conjunctivitis 29.4 IFNG IL2 IL4 IL5 MUC16 RNASE3
7 dermatitis, atopic 29.4 CCL22 IFNG IGHE IL2 IL4 IL5
8 virus associated hemophagocytic syndrome 10.3 IL2 IL4
9 autoimmune vasculitis 10.3 IL2 IL4
10 jak3-deficient severe combined immunodeficiency 10.2 IL2 IL4
11 variola major 10.2 IFNG IL2
12 fixed drug eruption 10.2 IFNG IL2
13 berylliosis 10.2 IFNG IL2
14 hyperlucent lung 10.2 IFNG IL4
15 autoimmune myocarditis 10.2 IFNG IL4
16 eosinophilic fasciitis 10.2 IFNG IL5
17 sulfamethoxazole allergy 10.2 IL4 IL5
18 cephalosporin allergy 10.2 IFNG IL5
19 autoimmune gastritis 10.2 IL2 IL4
20 trichinosis 10.2 IL4 IL5
21 baylisascariasis 10.2 IFNG IL4
22 penicillin allergy 10.2 IFNG IL4
23 crustacean allergy 10.2 IFNG IL4
24 non-suppurative otitis media 10.2 IL4 IL5
25 clonorchiasis 10.2 IFNG IL2
26 eosinophilic meningitis 10.2 IL4 IL5
27 crohn's colitis 10.2 IFNG IL2
28 vulvovaginal candidiasis 10.2 IL2 IL4
29 intestinal schistosomiasis 10.2 IL4 IL5
30 cardiac sarcoidosis 10.2 IFNG IL5
31 chronic tic disorder 10.2 IL4 IL5
32 filarial elephantiasis 10.2 IL4 IL5
33 eosinophilia-myalgia syndrome 10.2 IFNG IL5
34 necatoriasis 10.2 CCL22 IL5
35 strongyloidiasis 10.2 IFNG IL5
36 seborrheic infantile dermatitis 10.2 IL3 IL5
37 ascaris lumbricoides infection 10.2 IFNG IL5
38 chronic active epstein-barr virus infection 10.2 IFNG IL2
39 intermediate uveitis 10.2 IFNG IL2
40 hypereosinophilic syndrome, idiopathic 10.2 IL3 IL5
41 hypersplenism 10.2 IFNG IL4
42 orofacial granulomatosis 10.2 IFNG IL4
43 corneal ulcer 10.2
44 buruli ulcer 10.2 IFNG IL4
45 posterior uveitis 10.2 IFNG IL2
46 primary systemic mycosis 10.2 IFNG IL4
47 mycoplasma pneumoniae pneumonia 10.2 IFNG IL4
48 poliomyelitis 10.2 IFNG IL4
49 opisthorchiasis 10.2 IL4 MUC16
50 eales disease 10.2 IFNG IL4

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to Atopic Keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

Human phenotypes related to Atopic Keratoconjunctivitis:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 corneal opacity 59 32 hallmark (90%) Very frequent (99-80%) HP:0007957
2 dry skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0000958
3 keratoconjunctivitis sicca 59 32 hallmark (90%) Very frequent (99-80%) HP:0001097
4 blepharitis 59 32 frequent (33%) Frequent (79-30%) HP:0000498
5 loss of eyelashes 59 32 frequent (33%) Frequent (79-30%) HP:0011457
6 corneal neovascularization 59 32 frequent (33%) Frequent (79-30%) HP:0011496
7 chemosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012375
8 keratitis 59 Very frequent (99-80%)
9 abnormality of the eyelid 59 Frequent (79-30%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
2 Calcineurin Inhibitors Phase 3,Not Applicable
3 Anti-Infective Agents Phase 3,Not Applicable
4 Immunologic Factors Phase 3,Not Applicable
5 Dermatologic Agents Phase 3,Not Applicable
6 Cyclosporins Phase 3,Not Applicable
7 Ophthalmic Solutions Phase 3,Not Applicable
8 Antifungal Agents Phase 3,Not Applicable
9 Antirheumatic Agents Phase 3,Not Applicable
10 Pharmaceutical Solutions Phase 3,Not Applicable
11 Immunosuppressive Agents Phase 3,Not Applicable
12 Antibodies, Monoclonal Phase 1
13 Immunoglobulin G Phase 1
14 Immunoglobulins Phase 1
15 Antibodies Phase 1
16
Tacrolimus Approved, Investigational 104987-11-3 445643 439492

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis Completed NCT00884585 Phase 3 Cyclosporine Vehicle;Cyclosporine 0.010%
2 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Active, not recruiting NCT03379311 Phase 1 AK002
3 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
4 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Recruiting NCT03557203

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

41
Eye, Skin, Bone, T Cells, Lung, Tonsil, Pancreas

Publications for Atopic Keratoconjunctivitis

Articles related to Atopic Keratoconjunctivitis:

(show top 50) (show all 96)
# Title Authors Year
1
Atopic keratoconjunctivitis: A diagnostic dilemma-a case report. ( 29668589 )
2018
2
Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review. ( 29610174 )
2018
3
Immunopathological Features of Severe Chronic Atopic Keratoconjunctivitis and Effects of Topical Cyclosporine Treatment. ( 30189151 )
2018
4
Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing. ( 30471305 )
2018
5
Management of advanced ocular surface disease in patients with severe atopic keratoconjunctivitis. ( 30528292 )
2018
6
Ocular Surface Squamous Neoplasia Associated with Atopic Keratoconjunctivitis. ( 28275599 )
2017
7
Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice. ( 28855579 )
2017
8
Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case. ( 28138334 )
2017
9
Successful Subcutaneous Allergen-Specific Immunotherapy in Refractory Atopic Keratoconjunctivitis: A Case Report. ( 29422859 )
2017
10
Atopic keratoconjunctivitis: long-term results of medical treatment and penetrating keratoplasty. ( 28076564 )
2016
11
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. ( 27901637 )
2016
12
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
13
Atopic keratoconjunctivitis with corneal ulcer. Case report. ( 29450349 )
2016
14
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. ( 26278858 )
2015
15
Involvement of Chemokines and a CD4-Positive T Cell Subset in the Development of Conjunctival Secondary Lymphoid Follicles in an Atopic Keratoconjunctivitis Mouse Model. ( 26302769 )
2015
16
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. ( 25682856 )
2015
17
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. ( 25923050 )
2015
18
Functional visual acuity assessment of severe atopic keratoconjunctivitis. ( 25289719 )
2014
19
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. ( 24439439 )
2014
20
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. ( 25705372 )
2014
21
Central corneal thickness in patients with atopic keratoconjunctivitis. ( 25240805 )
2014
22
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. ( 23949491 )
2013
23
Atopic keratoconjunctivitis. ( 23406935 )
2013
24
Atopic keratoconjunctivitis: A review. ( 24342754 )
2013
25
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. ( 23886231 )
2013
26
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? ( 23106347 )
2013
27
Topical cyclosporine for atopic keratoconjunctivitis. ( 22972132 )
2012
28
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. ( 22581322 )
2012
29
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. ( 22441637 )
2012
30
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. ( 22092652 )
2012
31
Atopic keratoconjunctivitis: present day diagnosis. ( 22872669 )
2012
32
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. ( 22717457 )
2012
33
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. ( 22486642 )
2012
34
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. ( 22378107 )
2012
35
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. ( 22275342 )
2012
36
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. ( 21541276 )
2011
37
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. ( 22606467 )
2011
38
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. ( 20861732 )
2011
39
Omalizumab for severe atopic keratoconjunctivitis. ( 22791726 )
2010
40
Atopic keratoconjunctivitis and atopic dermatitis. ( 20720488 )
2010
41
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. ( 20657166 )
2010
42
Systemic cyclosporin A in severe atopic keratoconjunctivitis. ( 20491051 )
2010
43
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. ( 20482394 )
2010
44
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. ( 18721214 )
2009
45
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). ( 19693288 )
2009
46
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. ( 18782111 )
2008
47
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. ( 18724148 )
2008
48
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 18584874 )
2008
49
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. ( 18614131 )
2008
50
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. ( 17620070 )
2007

Variations for Atopic Keratoconjunctivitis

Expression for Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for Atopic Keratoconjunctivitis

Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL22 IFNG IGHE IL2 IL3 IL4
2
Show member pathways
13.49 CCL22 IFNG IL2 IL3 IL4 IL5
3
Show member pathways
13.38 CCL22 IFNG IL2 IL3 IL4 IL5
4
Show member pathways
13.22 CCL22 IFNG IGHE IL2 IL3 IL4
5
Show member pathways
13.13 CCL22 IL2 IL3 IL4 IL5
6
Show member pathways
12.72 IFNG IL2 IL3 IL4 IL5 PRG2
7 12.7 IFNG IL2 IL3 IL4 IL5
8
Show member pathways
12.51 IFNG IGHE IL2 IL4
9
Show member pathways
12.47 IFNG IL2 IL4 IL5
10
Show member pathways
12.46 IGHE IL3 IL4 IL5
11 12.43 IFNG IL2 IL3 IL4
12
Show member pathways
12.39 IFNG IL2 IL3 IL4
13
Show member pathways
12.31 IFNG IL2 IL4 IL5
14
Show member pathways
12.31 IFNG IL2 IL3 IL4 IL5
15
Show member pathways
12.22 IFNG IL4 IL5 MUC5AC
16
Show member pathways
12.18 IFNG IL2 IL4
17
Show member pathways
12.17 IFNG IL2 IL3 IL4 IL5
18
Show member pathways
12.02 IL2 IL3 IL5
19
Show member pathways
11.95 CCL22 IFNG IL2 IL3 IL4 IL5
20 11.91 IFNG IL2 IL4
21 11.88 CCL22 IGHE IL4
22
Show member pathways
11.87 IFNG IL2 IL4
23 11.79 IL3 IL4 IL5
24 11.78 IFNG IL2 IL3
25 11.78 IFNG IL2 IL3 IL4 IL5
26 11.74 IFNG IL2 IL4 IL5
27 11.71 IFNG IL2 IL4 IL5
28 11.65 CCL22 IFNG IL2 IL4
29 11.57 IGHE IL4 IL5
30
Show member pathways
11.43 IFNG IL2 IL3 IL4 IL5
31 11.26 IFNG IL4 IL5
32 11.19 IFNG IL2 IL4 IL5
33 11.11 IFNG IL2
34 11.11 CCL22 IL2 IL3 IL4 IL5
35 11.02 CCL22 IFNG IL2 IL4 IL5
36 10.97 IFNG IL2 IL4 IL5
37 10.92 CCL22 IL2 IL3 IL4 IL5 PRG2
38 10.48 IFNG IL2 IL3 IL4 IL5

GO Terms for Atopic Keratoconjunctivitis

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CCL22 IFNG IL2 IL3 IL4 IL5
2 extracellular region GO:0005576 9.36 CCL22 IFNG IGHE IL2 IL3 IL4

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.78 IFNG IL2 IL3 IL5
2 cell-cell signaling GO:0007267 9.69 CCL22 IL2 IL3
3 MAPK cascade GO:0000165 9.67 IL2 IL3 IL5
4 regulation of signaling receptor activity GO:0010469 9.63 CCL22 IFNG IL2 IL3 IL4 IL5
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.56 IFNG IL2 IL3 IL4
6 positive regulation of B cell proliferation GO:0030890 9.5 IL2 IL4 IL5
7 positive regulation of T cell differentiation GO:0045582 9.46 IL2 IL4
8 regulation of regulatory T cell differentiation GO:0045589 9.43 IFNG IL2
9 cytokine-mediated signaling pathway GO:0019221 9.43 CCL22 IGHE IL2 IL3 IL4 IL5
10 positive regulation of immunoglobulin secretion GO:0051024 9.4 IL2 IL5
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.37 IL2 IL4
12 immune response GO:0006955 9.23 CCL22 IFNG IGHE IL2 IL3 IL4

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 IL2 IL3 IL5
2 growth factor activity GO:0008083 9.26 IL2 IL3 IL4 IL5
3 cytokine activity GO:0005125 9.1 CCL22 IFNG IL2 IL3 IL4 IL5

Sources for Atopic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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