MCID: ATR011
MIFTS: 68

Atrial Fibrillation

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Atrial Fibrillation

MalaCards integrated aliases for Atrial Fibrillation:

Name: Atrial Fibrillation 12 37 29 29 55 6 43 3 44 15 63 63 73
Fibrillation, Atrial 40
a-Fib 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060224
ICD10 33 I48
ICD9CM 35 427.31
MeSH 44 D001281
NCIt 50 C50466
KEGG 37 H00731
UMLS 73 C0004238

Summaries for Atrial Fibrillation

PubMed Health : 63 About atrial fibrillation: Atrial fibrillation (A-tre-al fi-bri-LA-shun), or AF, is the most common type of arrhythmia (ah-RITH-me-ah). An arrhythmia is a problem with the rate or rhythm of the heartbeat. During an arrhythmia, the heart can beat too fast, too slow, or with an irregular rhythm.AF occurs if rapid, disorganized electrical signals cause the heart's two upper chambers—called the atria (AY-tree-uh)—to fibrillate. The term "fibrillate" means to contract very fast and irregularly.In AF, blood pools in the atria. It isn't pumped completely into the heart's two lower chambers, called the ventricles (VEN-trih-kuls). As a result, the heart's upper and lower chambers don't work together as they should.People who have AF may not feel symptoms. However, even when AF isn't noticed, it can increase the risk of stroke. In some people, AF can cause chest pain or heart failure, especially if the heart rhythm is very rapid.AF may happen rarely or every now and then, or it may become an ongoing or long-term heart problem that lasts for years.

MalaCards based summary : Atrial Fibrillation, also known as fibrillation, atrial, is related to familial atrial fibrillation and progressive familial heart block, type ia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Atrial Fibrillation is KCNQ1 (Potassium Voltage-Gated Channel Subfamily Q Member 1), and among its related pathways/superpathways are Vascular smooth muscle contraction and Adrenergic signaling in cardiomyocytes. The drugs Amiodarone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

MedlinePlus : 43 An arrhythmia is a problem with the speed or rhythm of the heartbeat. Atrial fibrillation (AF) is the most common type of arrhythmia. The cause is a disorder in the heart's electrical system. Often, people who have AF may not even feel symptoms. But you may feel Palpitations -- an abnormal rapid heartbeat Shortness of breath Weakness or difficulty exercising Chest pain Dizziness or fainting Fatigue Confusion AF can lead to an increased risk of stroke. In many patients, it can also cause chest pain, heart attack, or heart failure. Doctors diagnose AF using family and medical history, a physical exam, and a test called an electrocardiogram (EKG), which looks at the electrical waves your heart makes. Treatments include medicines and procedures to restore normal rhythm. NIH: National Heart, Lung, and Blood Institute

CDC : 3 Electrical activity of a normal heart (left) and a heart with atrial fibrillation (right).

Disease Ontology : 12 A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.

Wikipedia : 76 Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm characterized by rapid and irregular... more...

Related Diseases for Atrial Fibrillation

Diseases in the Atrial Fibrillation family:

Atrial Fibrillation, Familial, 3 Atrial Fibrillation, Familial, 1
Atrial Fibrillation, Familial, 2 Atrial Fibrillation, Familial, 4
Atrial Fibrillation, Familial, 5 Atrial Fibrillation, Familial, 6
Atrial Fibrillation, Familial, 7 Atrial Fibrillation, Familial, 8
Atrial Fibrillation, Familial, 9 Atrial Fibrillation, Familial, 10
Atrial Fibrillation, Familial, 11 Atrial Fibrillation, Familial, 12
Atrial Fibrillation, Familial, 13 Atrial Fibrillation, Familial, 14
Atrial Fibrillation, Familial, 15 Atrial Fibrillation, Familial, 18
Familial Atrial Fibrillation

Diseases related to Atrial Fibrillation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 familial atrial fibrillation 33.1 ABCC9 GJA5 KCNA5 KCNE2 KCNH2 KCNJ2
2 progressive familial heart block, type ia 31.9 GJA5 SCN5A
3 right bundle branch block 31.5 SCN1B SCN2B SCN3B SCN5A
4 atrioventricular block 31.3 KCNE2 KCNH2 KCNQ1 NPPB SCN5A
5 short qt syndrome 31.3 KCNE2 KCNH2 KCNJ2 KCNQ1
6 cardiac conduction defect 31.3 KCNH2 KCNQ1 SCN5A
7 first-degree atrioventricular block 31.3 GJA5 SCN5A
8 central sleep apnea 31.2 NPPA NPPB
9 catecholaminergic polymorphic ventricular tachycardia 31.2 KCNH2 KCNJ2 SCN5A
10 ventricular fibrillation, paroxysmal familial, 1 31.2 KCNE2 KCNH2 KCNQ1 SCN5A
11 atrial standstill 31.1 GJA5 NPPA SCN5A
12 aortic valve disease 2 31.1 ACE MYL4 NPPA NPPB
13 third-degree atrioventricular block 31.1 KCNE2 NPPB
14 cardiac arrest 31.0 ACE KCNQ1 SCN5A
15 cardiac arrhythmia 30.9 KCNE2 KCNH2 KCNJ2 KCNQ1 SCN5A
16 congestive heart failure 30.9 ACE ADRB1 NPPA NPPB
17 syncope 30.8 KCNH2 KCNJ2 KCNQ1 NPPA NPPB SCN5A
18 systolic heart failure 30.8 ACE ADRB1 NPPB
19 pulmonary hypertension 30.8 ACE KCNA5 NPPA NPPB
20 acute myocardial infarction 30.6 ACE ADRB1 NPPA NPPB
21 tetralogy of fallot 30.5 GJA5 KCNH2 NPPA NPPB
22 brugada syndrome 30.5 ABCC9 KCNA5 KCNE2 KCNH2 KCNQ1 SCN1B
23 coronary artery anomaly 30.4 ACE ADRB1 NPPA NPPB
24 myocardial infarction 30.4 ABCC9 ACE ADRB1 NPPA NPPB
25 timothy syndrome 30.4 KCNH2 KCNQ1
26 hypertension, essential 30.2 ACE ADRB1 NPPA NPPB
27 chronic kidney failure 30.2 ACE NPPA NPPB
28 chagas disease 29.8 ACE ADRB1 NPPB
29 heart disease 29.7 ACE ADRB1 GJA5 KCNE2 KCNH2 KCNJ2
30 atrial standstill 1 29.7 ACE ADRB1 GJA5 NPPB SCN1B SCN5A
31 long qt syndrome 29.5 ADRB1 KCNA5 KCNE2 KCNH2 KCNJ2 KCNQ1
32 dilated cardiomyopathy 29.3 ABCC9 ACE ADRB1 GJA5 KCNH2 KCNQ1
33 atrial fibrillation, familial, 15 12.5
34 atrial fibrillation, familial, 3 12.5
35 atrial fibrillation, familial, 4 12.5
36 atrial fibrillation, familial, 6 12.5
37 atrial fibrillation, familial, 7 12.5
38 atrial fibrillation, familial, 9 12.5
39 atrial fibrillation, familial, 10 12.5
40 atrial fibrillation, familial, 11 12.5
41 atrial fibrillation, familial, 12 12.5
42 atrial fibrillation, familial, 13 12.5
43 atrial fibrillation, familial, 14 12.5
44 atrial fibrillation, familial, 18 12.4
45 atrial fibrillation and stroke 12.4
46 atrial fibrillation, familial, 1 12.4
47 atrial fibrillation, familial, 2 12.4
48 atrial fibrillation, familial, 5 12.4
49 atrial fibrillation, familial, 8 12.4
50 long qt syndrome 10 11.9

Graphical network of the top 20 diseases related to Atrial Fibrillation:



Diseases related to Atrial Fibrillation

Symptoms & Phenotypes for Atrial Fibrillation

UMLS symptoms related to Atrial Fibrillation:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Atrial Fibrillation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 NPPA NUP155 SCN3B SCN5A VKORC1 ABCC9
2 homeostasis/metabolism MP:0005376 9.8 ABCC9 ACE ADRB1 GJA5 KCNA5 KCNE2
3 muscle MP:0005369 9.28 ABCC9 ADRB1 GJA5 KCNA5 KCNH2 KCNJ2

Drugs & Therapeutics for Atrial Fibrillation

PubMedHealth treatment related to Atrial Fibrillation: 63

Treatment for atrial fibrillation (AF) depends on how often you have symptoms, how severe they are, and whether you already have heart disease. General treatment options include medicines, medical procedures, and lifestyle changes.

Drugs for Atrial Fibrillation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 586)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amiodarone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 1951-25-3 2157
2
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
3
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
4
Propafenone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 54063-53-5 4932
5
Sotalol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 959-24-0, 3930-20-9 5253
6
Carvedilol Approved, Investigational Phase 4,Phase 3,Not Applicable 72956-09-3 2585
7
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
9
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
10
Rivaroxaban Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 366789-02-8
11
Ticagrelor Approved Phase 4,Phase 3,Phase 1 274693-27-5 9871419
12
Warfarin Approved Phase 4,Phase 3,Phase 2,Not Applicable 81-81-2 6691 54678486
13
Diltiazem Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 42399-41-7 39186
14
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
15
Irbesartan Approved, Investigational Phase 4,Phase 3 138402-11-6 3749
16
Acenocoumarol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 152-72-7 9052 54676537
17
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 3 69-72-7 338
18
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
19
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
21
Phenprocoumon Approved, Investigational Phase 4,Phase 3 435-97-2 9908 54680692
22
Enfuvirtide Approved, Investigational Phase 4 159519-65-0 16130199
23
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
24
Dalteparin Approved Phase 4,Phase 3,Phase 2 9005-49-6
25 fluindione Approved, Investigational Phase 4,Phase 3 957-56-2
26
Amlodipine Approved Phase 4,Not Applicable 88150-42-9 2162
27
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
28
Simvastatin Approved Phase 4,Phase 2,Not Applicable 79902-63-9 54454
29
Telmisartan Approved, Investigational Phase 4,Not Applicable 144701-48-4 65999
30
Ranolazine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 142387-99-3, 95635-55-5 56959
31
Dobutamine Approved Phase 4,Phase 3 34368-04-2 36811
32
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
33
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068 160954
34
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
35
Bisoprolol Approved Phase 4,Early Phase 1,Not Applicable 66722-44-9 2405
36
Candesartan cilexetil Approved Phase 4,Phase 3 145040-37-5 2540
37
Captopril Approved Phase 4,Not Applicable 62571-86-2 44093
38
Enalapril Approved, Vet_approved Phase 4,Phase 3,Not Applicable 75847-73-3 5362032 40466924
39
Enalaprilat Approved Phase 4,Phase 3,Not Applicable 76420-72-9 6917719
40
Eplerenone Approved Phase 4,Phase 3,Phase 2 107724-20-9 150310 443872
41
Lisinopril Approved, Investigational Phase 4,Not Applicable 83915-83-7, 76547-98-3 5362119
42
Nebivolol Approved, Investigational Phase 4,Not Applicable 152520-56-4, 99200-09-6, 118457-14-0 71301
43
Ramipril Approved Phase 4,Phase 2,Phase 3,Not Applicable 87333-19-5 5362129
44
Spironolactone Approved Phase 4,Phase 3,Phase 2,Not Applicable 1952-01-7, 52-01-7 5833
45
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
46
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 58-61-7 60961
47
Ibutilide Approved Phase 4,Not Applicable 122647-32-9, 122647-31-8 60753
48
Digoxin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 20830-75-5 30322 2724385
49
Apixaban Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 503612-47-3 10182969
50
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594

Interventional clinical trials:

(show top 50) (show all 2389)
# Name Status NCT ID Phase Drugs
1 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
2 Intensive Statin Therapy Effect on Post-Operative Atrial Fibrillation (POAF) Unknown status NCT02029534 Phase 4 Atorvastatin 20 mg;Atorvastatin 80 mg
3 Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer Unknown status NCT00724581 Phase 4 Amiodarone
4 Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation Unknown status NCT00196209 Phase 4
5 The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation Unknown status NCT02808897 Phase 4
6 AF Ablation With or Without ROX Coupler Study Unknown status NCT02243891 Phase 4
7 Line Versus Spot Ablation in Persistent Atrial Fibrillation Unknown status NCT00196157 Phase 4
8 Left Atrial Ablation of Paroxysmal Atrial Fibrillation With Implantable Loop Recorder Follow Up Study: The LAAPITUP 2 Study Unknown status NCT01504451 Phase 4
9 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
10 Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation Unknown status NCT02145546 Phase 4 Amiodarone;Propafenone;Sotalol
11 Rate Control in Atrial Fibrillation Unknown status NCT02251509 Phase 4 Carvedilol;Metoprolol tartrate
12 Graz Study on the Risk of Atrial Fibrillation Unknown status NCT01461434 Phase 4
13 Vernakalant Versus Flecainide: Atrial Contractility Unknown status NCT01646281 Phase 4 Vernakalant;Flecainide
14 Catheter Ablation Versus Antiarrythmic Drugs for Atrial Fibrillation in China Unknown status NCT01341353 Phase 4 Digaoxin,amiodarone,β receptor antagonist, Calcium Antagonists
15 Efficacy and Safety Study of Catheter Ablation for Atrial Fibrillation Unknown status NCT01113294 Phase 4
16 Dronedarone in Pacemakers Patients With Paroxysmal Atrial Fibrillation Unknown status NCT01070667 Phase 4 Dronedarone;Placebo
17 Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study Unknown status NCT02642419 Phase 4 Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
18 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
19 Pulmonary Vein (PV) -Isolation: Arrhythmogenic Vein(s) Versus All Veins Unknown status NCT00605748 Phase 4
20 Low Dose of Diltiazem for Rate Control of Atrial Fibrillation Unknown status NCT00834925 Phase 4 low dose diltiazem
21 Evaluation of WATCHMAN Left Atrial Appendage Occlusion Device in Patients With Atrial Fibrillation Versus Rivaroxaban Unknown status NCT02549963 Phase 4 Rivaroxaban
22 Anti-inflammatory Effects of Rivaroxaban Versus Dabigatran Unknown status NCT02331602 Phase 4 Rivaroxaban;Dabigatran
23 Pulmonary Vein Isolation With Versus Without Continued Antiarrhythmic Drug Treatment in Subjects With Recurrent Atrial Fibrillation Unknown status NCT02475642 Phase 4
24 N-3 Fatty Acids for the Prevention of Atrial Fibrillation in Patients With Acute Heart Failure Unknown status NCT00692718 Phase 4 Epadel, Eicosapentaenoic acid
25 A Prospective Randomized Study Comparing Radiofrequency Energy With Cryoenergy Unknown status NCT00773539 Phase 4
26 EvaluAtion of Predictive Value of Multisite Intracardiac EchoCardiography During Imaging of Structure and funCTION of Left Atrial Appendage in Comparison to Transesophageal Echocardiography Unknown status NCT01371279 Phase 4
27 Irbesartan and Adhesion Molecules in AF Unknown status NCT00613496 Phase 4 irbesartan;placebo
28 Anticoagulation in Stent Intervention Unknown status NCT01141153 Phase 4 Acetylsalicylic Acid + clopidogrel + acenocoumarol;Acetylsalicylic Acid + clopidogrel
29 Corticosteroid Pulse After Ablation Unknown status NCT00807586 Phase 4 Solumedrol;Placebo
30 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
31 Left Atrial Thrombus Reduction - Effect of Dabigatran Versus Phenprocoumon Unknown status NCT02591225 Phase 4 Dabigatranetexilate;Phenprocoumon
32 Safety of "Ticagrelor+ Warfarin"in Comparison With "Clopidogrel+Aspirin+Warfarin" Unknown status NCT02206815 Phase 4 Ticagrelor+Warfarin;Clopidogrel+Aspirin+Warfarin
33 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
34 Catheter Contact Force and Electrograms Unknown status NCT01587404 Phase 4
35 Ventricular Pacing Site Selection (V-PASS) Unknown status NCT00292383 Phase 4
36 Resolution of Left Atrial-Appendage Thrombus - Effects of Dabigatran in Patients With AF Unknown status NCT02256683 Phase 4 Dabigatran etexilate;Phenprocoumon
37 SmartTouch Catheter for Left Anterior Line - SmarT Line Study Unknown status NCT02217657 Phase 4
38 Registry for Estimation of Warfarin and Rivaroxaban in Atrial Fibrillation Patients With Coronary Stent Implantation Unknown status NCT02024230 Phase 4 Warfarin or Rivaroxaban
39 The Efficacy and Safety of CARTO 3D Mapping System Versus Conventional Method in AF and VT Unknown status NCT00959205 Phase 4
40 Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation Unknown status NCT00776633 Phase 4 aspirin;clopidogrel;oral anticoagulation
41 Potential Effect of Topical Imiquimod on Atrial Ectopy in Patients With Actinic Keratosis Unknown status NCT01413763 Phase 4 Imiquimod cream 3.75%;Placebo cream
42 Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation Unknown status NCT02161965 Phase 4 Rivaroxaban;Fluindione;Warfarin
43 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
44 Applying Pharmacogenetics to Warfarin Dosing in Chinese Patients Unknown status NCT01610141 Phase 4
45 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
46 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
47 Aliskiren or Amlodipine in Hypertensive Hemodialysed Patients Unknown status NCT01394770 Phase 4 Aliskiren
48 Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients Unknown status NCT01011660 Phase 4 Amlodipine, Telmisartan, Amiloride Compound , Simvastatin
49 Safety of Amiodarone and Ranolazine Together in Patients With Angina Unknown status NCT01558830 Phase 4 ranolazine;placebo
50 Safety and Feasibility of Arrhythmia Ablation Using the Amigo Remote Robotic System as Compared With Manual Ablation Unknown status NCT01834872 Phase 4

Search NIH Clinical Center for Atrial Fibrillation

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: atrial fibrillation

Genetic Tests for Atrial Fibrillation

Genetic tests related to Atrial Fibrillation:

# Genetic test Affiliating Genes
1 Atrial Fibrillation 29

Anatomical Context for Atrial Fibrillation

MalaCards organs/tissues related to Atrial Fibrillation:

41
Heart, Testes, Lung, Kidney, Brain, Endothelial, Prostate

Publications for Atrial Fibrillation

Articles related to Atrial Fibrillation:

(show top 50) (show all 2690)
# Title Authors Year
1
Atrial fibrillation and stroke risk factors induce decline in creatinine clearance: Is there a specific "fibrillatory kidney disease"? ( 29306477 )
2018
2
Acute pericarditis following second-generation cryoballoon ablation for atrial fibrillation. ( 29445985 )
2018
3
Detecting cerebrovascular changes in the brain caused by hypertension in atrial fibrillation group using acoustocerebrography. ( 29979716 )
2018
4
Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial. ( 29447773 )
2018
5
Atrial Fibrillation Characteristics in Patients on Haemodialysis vs. Peritoneal Dialysis. ( 29445225 )
2018
6
Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients. ( 29375116 )
2018
7
Atrial fibrillation in acute Chagas disease acquired via oral transmission: a case report. ( 29972578 )
2018
8
Rhythm control better prevents stroke and mortality than rate control strategies in patients with atrial fibrillation - A nationwide cohort study. ( 29980369 )
2018
9
Atrial fibrillation detected after stroke is related to a low risk of ischemic stroke recurrence. ( 29444969 )
2018
10
Preventing Postoperative Atrial Fibrillation: is There One Best Option? ( 29452262 )
2018
11
Dabigatran, Rivaroxaban, and Warfarin in the Oldest Adults with Atrial Fibrillation in Taiwan. ( 29975405 )
2018
12
Analysis of Haematological and Biochemical Blood Parameters After Electrical Cardioversion of Atrial Fibrillation in Dogs. ( 29978135 )
2018
13
Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults. ( 29390969 )
2018
14
Atrial fibrillation and stroke prevention: where we are and where we should be. ( 29853572 )
2018
15
Epicardial Fat Thickness and Free Fatty Acid Level are Predictors of Acute Ischemic Stroke with Atrial Fibrillation. ( 29971268 )
2018
16
Stroke Risk in Patients With Reduced Ejection Fraction After Myocardial Infarction Without Atrial Fibrillation. ( 29447733 )
2018
17
Kohlmeier-Degos disease with constrictive pericarditis and atrial fibrillation. ( 29974345 )
2018
18
Uncontrolled blood pressure affects atrial remodeling and adverse clinical outcome in paroxysmal atrial fibrillation. ( 29446840 )
2018
19
Anticoagulation strategies in patients with atrial fibrillation after PCI or with ACS : The end of triple therapy? ( 29188358 )
2018
20
Letter regarding the article "Detecting atrial fibrillation by deep convolutional neural networks" by Xia et al. ( 29975853 )
2018
21
Concurrent renal dysfunction with ischemic heart disease is an important determinant for cardiac and cerebrovascular mortality in patients on chronic digoxin therapy for atrial fibrillation. ( 29971208 )
2018
22
The Optimal Anti-Coagulation for Enhanced-Risk Patients Post-Catheter Ablation for Atrial Fibrillation (OCEAN) trial. ( 29447772 )
2018
23
Prognostic value of von Willebrand factor in patients with atrial fibrillation: A meta-analysis. ( 29979393 )
2018
24
Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial. ( 29389037 )
2018
25
Incident Atrial Fibrillation and Stroke in Patients With Atrial Flutter. ( 29729880 )
2018
26
Screening for Atrial Fibrillation using Smartphone-based Technology and Layperson Volunteers: High-Tech Meets Community Participatory Research for the Best of Both Worlds. ( 29981478 )
2018
27
The unrecognized role of tumor suppressor genes in atrial fibrillation. ( 29126922 )
2018
28
Outcomes and Management of Patients With Severe Pulmonary Vein Stenosis From Prior Atrial Fibrillation Ablation. ( 29752377 )
2018
29
Iatrogenic atrial septal defect with right-to-left shunt following atrial fibrillation ablation in a patient with arrhythmogenic right ventricular cardiomyopathy. ( 29755946 )
2018
30
Elevated Incidence of Atrial Fibrillation and Stroke in Patients With Atrial Flutter-A Population-Based Study. ( 29801742 )
2018
31
Atrial fibrillation and stroke: The more we learn, the less we understand. ( 29910049 )
2018
32
Impact of antibiotic prophylaxis on catheter-associated urinary tract infections during atrial fibrillation ablation. ( 29445984 )
2018
33
Low Risk of Pulmonary Vein Stenosis After Contemporary Atrial Fibrillation Ablationa88- Lessons From Repeat Procedures After Radiofrequency Current, Cryoballoon, and Laser Balloon. ( 29618679 )
2018
34
High-Resolution Infrared Thermography of Esophageal Temperature During Radiofrequency Ablation of Atrial Fibrillation. ( 29449354 )
2018
35
Spontaneous massive hemothorax presenting as a late complication of stent implantation in a patient with pulmonary vein stenosis following radiofrequency ablation for atrial fibrillation. ( 29325041 )
2018
36
Cryptogenic Acute Ischemic Stroke: Assessment of the Performance of a New Continuous Long-Term Monitoring System in the Detection of Atrial Fibrillation. ( 29972414 )
2018
37
Pulmonary Vein Stenosis After Atrial Fibrillation Ablation: An Iatrogenic Problem Larger Than the Primary Problem. ( 29752378 )
2018
38
Predictors of future onset of atrial fibrillation in hypertrophic cardiomyopathy. ( 29884599 )
2018
39
Subclinical device-detected atrial fibrillation and stroke risk: a systematic review and meta-analysis. ( 29340587 )
2018
40
Left atrial low-voltage zone ablation of persistent atrial fibrillation in a patient with myotonic dystrophy: A case report. ( 29951149 )
2018
41
Insights into atrial fibrillation newly diagnosed after stroke: Can the brain rule the heart? ( 29444967 )
2018
42
Response by Rowin et al to Letter Regarding Article, "Clinical Profile and Consequences of Atrial Fibrillation in Hypertrophic Cardiomyopathy". ( 29866781 )
2018
43
Cor Triatriatum Sinister: An Unusual Cause of Atrial Fibrillation in Adults. ( 29808125 )
2018
44
Effectiveness and Safety of Anticoagulants in Adults with Non-valvular Atrial Fibrillation and Concomitant Coronary/Peripheral Artery Disease. ( 29807001 )
2018
45
Impact of the pulmonary vein orifice area assessed using intracardiac echocardiography on the outcome of radiofrequency catheter ablation for atrial fibrillation. ( 29445983 )
2018
46
Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation. ( 29306474 )
2018
47
Primary and secondary prevention of stroke and systemic embolism with rivaroxaban in patients with non-valvular atrial fibrillation : Sub-analysis of the EXPAND Study. ( 29980835 )
2018
48
New-Onset Atrial Fibrillation After PCIA orA CABGA forA Left Main Disease: The EXCEL Trial. ( 29447735 )
2018
49
Case report of recurrent atrial fibrillation induced by thyrotropin-secreting pituitary adenoma with Graves' disease. ( 29901603 )
2018
50
Long-Term Outcomes of Post-OperativeA Atrial Fibrillation: Guilty as Charged. ( 29447736 )
2018

Variations for Atrial Fibrillation

ClinVar genetic disease variations for Atrial Fibrillation:

6
(show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 KCNQ1 NM_000218.2(KCNQ1): c.418A> G (p.Ser140Gly) single nucleotide variant Pathogenic rs120074192 GRCh37 Chromosome 11, 2549189: 2549189
2 KCNQ1 NM_000218.2(KCNQ1): c.418A> G (p.Ser140Gly) single nucleotide variant Pathogenic rs120074192 GRCh38 Chromosome 11, 2527959: 2527959
3 SCN5A NM_000335.4(SCN5A): c.1410C> G (p.Asn470Lys) single nucleotide variant Pathogenic rs199473115 GRCh37 Chromosome 3, 38646328: 38646328
4 SCN5A NM_000335.4(SCN5A): c.1410C> G (p.Asn470Lys) single nucleotide variant Pathogenic rs199473115 GRCh38 Chromosome 3, 38604837: 38604837
5 SCN5A NM_198056.2(SCN5A): c.1963G> A (p.Glu655Lys) single nucleotide variant Likely pathogenic rs199473579 GRCh37 Chromosome 3, 38640469: 38640469
6 SCN5A NM_198056.2(SCN5A): c.1963G> A (p.Glu655Lys) single nucleotide variant Likely pathogenic rs199473579 GRCh38 Chromosome 3, 38598978: 38598978
7 KCNQ1 NM_000218.2(KCNQ1): c.421G> A (p.Val141Met) single nucleotide variant Pathogenic/Likely pathogenic rs199472687 GRCh37 Chromosome 11, 2549192: 2549192
8 KCNQ1 NM_000218.2(KCNQ1): c.421G> A (p.Val141Met) single nucleotide variant Pathogenic/Likely pathogenic rs199472687 GRCh38 Chromosome 11, 2527962: 2527962
9 KCNQ1 NM_000218.2(KCNQ1): c.625T> C (p.Ser209Pro) single nucleotide variant Pathogenic rs199472705 GRCh37 Chromosome 11, 2592575: 2592575
10 KCNQ1 NM_000218.2(KCNQ1): c.625T> C (p.Ser209Pro) single nucleotide variant Pathogenic rs199472705 GRCh38 Chromosome 11, 2571345: 2571345
11 SCN5A NM_198056.2(SCN5A): c.5624T> C (p.Met1875Thr) single nucleotide variant Likely pathogenic rs199473324 GRCh37 Chromosome 3, 38592239: 38592239
12 SCN5A NM_198056.2(SCN5A): c.5624T> C (p.Met1875Thr) single nucleotide variant Likely pathogenic rs199473324 GRCh38 Chromosome 3, 38550748: 38550748

Expression for Atrial Fibrillation

Search GEO for disease gene expression data for Atrial Fibrillation.

Pathways for Atrial Fibrillation

Pathways related to Atrial Fibrillation according to KEGG:

37
# Name Kegg Source Accession
1 Vascular smooth muscle contraction hsa04270
2 Adrenergic signaling in cardiomyocytes hsa04261

Pathways related to Atrial Fibrillation according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 ADRB1 GJA5 SCN1B SCN2B SCN3B SCN4B
2
Show member pathways
12.85 ADRB1 KCNQ1 MYL4 SCN1B SCN4B SCN5A
3
Show member pathways
12.48 SCN1B SCN2B SCN3B SCN4B SCN5A
4
Show member pathways
12.46 ABCC9 KCNE2 KCNH2 KCNJ2 KCNQ1 MYL4
5 12.38 ADRB1 SCN1B SCN2B SCN5A
6 12.19 KCNA5 KCNE2 KCNH2 KCNJ2 KCNQ1
7 12.01 KCNH2 KCNQ1 SCN3B SCN4B SCN5A
8
Show member pathways
12 ADRB1 KCNE2 KCNJ2 KCNQ1
9
Show member pathways
11.94 ABCC9 KCNA5 KCNH2 KCNJ2 KCNQ1
10
Show member pathways
11.82 SCN1B SCN2B SCN3B SCN4B SCN5A
11
Show member pathways
11.57 KCNE2 KCNQ1 SCN1B SCN2B SCN3B SCN4B
12 11.51 ACE ADRB1 KCNJ2
13 11.18 ABCC9 ADRB1 GJA5 KCNA5 KCNE2 KCNH2
14 11.13 SCN1B SCN2B SCN3B SCN4B SCN5A
15 10.9 NPPA NPPB
16 10.82 KCNJ2 KCNQ1

GO Terms for Atrial Fibrillation

Cellular components related to Atrial Fibrillation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 9.63 ABCC9 KCNA5 KCNE2 KCNH2 KCNJ2 KCNQ1
2 Z disc GO:0030018 9.61 KCNA5 SCN3B SCN5A
3 T-tubule GO:0030315 9.5 KCNJ2 SCN1B SCN5A
4 intercalated disc GO:0014704 9.43 GJA5 KCNA5 KCNJ2 SCN1B SCN4B SCN5A
5 voltage-gated sodium channel complex GO:0001518 9.02 SCN1B SCN2B SCN3B