MCID: ATR024
MIFTS: 22

Atrial Fibrillation and Stroke

Categories: Blood diseases, Respiratory diseases

Aliases & Classifications for Atrial Fibrillation and Stroke

MalaCards integrated aliases for Atrial Fibrillation and Stroke:

Name: Atrial Fibrillation and Stroke 54

Classifications:



Summaries for Atrial Fibrillation and Stroke

NINDS : 54 Atrial fibrillation (AF) describes the rapid, irregular beating of the left atrium (upper chamber) of the heart. These rapid contractions of the heart are weaker than normal contractions, resulting in slow flow of blood in the atrium. The blood pools and becomes sluggish and can result in the formation of blood clots. If a clot leaves the heart and travels to the brain, it can cause a stroke by blocking the flow of blood through cerebral arteries. Some people with AF have no symptoms, but others may experience a fluttering feeling in the area of the chest above the heart, chest pain, lightheadness or fainting, shortness of breath, and fatigue. AF is diagnosed by an electrocardiogram (ECG), a device that records the heart’s electrical activity. Other tests are often performed to rule out contributing causes, such as high blood pressure, an overactive thyroid gland, heart failure, faulty heart valves, lung disease, and stimulant or alcohol abuse. Some people will have no identifiable cause for their AF.

MalaCards based summary : Atrial Fibrillation and Stroke is related to atrial fibrillation and cerebrovascular disease. An important gene associated with Atrial Fibrillation and Stroke is NPPA (Natriuretic Peptide A). The drugs Warfarin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes.

Related Diseases for Atrial Fibrillation and Stroke

Graphical network of the top 20 diseases related to Atrial Fibrillation and Stroke:



Diseases related to Atrial Fibrillation and Stroke

Symptoms & Phenotypes for Atrial Fibrillation and Stroke

Drugs & Therapeutics for Atrial Fibrillation and Stroke

Drugs for Atrial Fibrillation and Stroke (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4 81-81-2 6691 54678486
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
4
Dabigatran Investigational Phase 4 211914-51-1
5 Cyclooxygenase Inhibitors Phase 4
6 Analgesics, Non-Narcotic Phase 4
7
protease inhibitors Phase 4
8 Fibrinolytic Agents Phase 4
9 Peripheral Nervous System Agents Phase 4
10 Antithrombin III Phase 4
11 HIV Protease Inhibitors Phase 4
12 Analgesics Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Serine Proteinase Inhibitors Phase 4
15 Antipyretics Phase 4
16 Platelet Aggregation Inhibitors Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Antithrombins Phase 4
19 Antirheumatic Agents Phase 4
20 Anticoagulants Phase 4
21 Nutmeg Approved
22 Mace

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial Completed NCT00256152 Phase 4
2 Effectiveness of Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Aortic and Mitral Valvular Atrial Fibrillation Patients Recruiting NCT02982850 Phase 4 Dabigatran;Acetylsalicylic acid;Warfarin
3 SILENT - Subclinical AtrIal FibrilLation and StrokE PreveNtion Trial Not yet recruiting NCT02004509 Phase 4 anticoagulant by physician criteria
4 Prevalence, Severity and Natural Course of Sleep Apnea After Cardiac Surgery Unknown status NCT02632162
5 Right Apical Versus Septal Pacing Trial Unknown status NCT00199498
6 The Nordic Atrial Fibrillation and Stroke Study Recruiting NCT02937077
7 Fibrosis, Inflammation and Brain Health in Atrial Fibrillation. The Norwegian Atrial Fibrillation and Stroke Study Recruiting NCT03816865
8 Impact of Obstructive Sleep Apnea on Outcomes in Acute Coronary Syndrome Recruiting NCT03793582
9 Massachusetts-wide Study of the Incidence of ATrial Fibrillation and Stroke Occurring After Discharge From Cardiac Surgery (MATRICeS) Active, not recruiting NCT03466125
10 HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy Active, not recruiting NCT01915615
11 Biological Bank for Studies Related to Atrial Fibrillation and Stroke Not yet recruiting NCT03611816

Search NIH Clinical Center for Atrial Fibrillation and Stroke

Genetic Tests for Atrial Fibrillation and Stroke

Anatomical Context for Atrial Fibrillation and Stroke

MalaCards organs/tissues related to Atrial Fibrillation and Stroke:

41
Heart, Brain, Testes, Lung, Thyroid, Kidney

Publications for Atrial Fibrillation and Stroke

Articles related to Atrial Fibrillation and Stroke:

(show top 50) (show all 231)
# Title Authors PMID Year
1
Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation-A report from the CHART-2 Study. 38
31104823 2019
2
Short lookback periods causing exaggerated stroke risk estimates in atrial fibrillation may expose patients to unnecessary anticoagulant treatment. 38
31112361 2019
3
Prevalence of atrial fibrillation and stroke risk assessment based on telemedicine screening tools in a primary healthcare setting. 38
31320151 2019
4
Advanced interatrial block is a surrogate for left atrial strain reduction which predicts atrial fibrillation and stroke. 38
30719798 2019
5
E-noise: An increasingly relevant health risk. 38
31362866 2019
6
Electrocardiographic evidence of abnormal atrial phenotype in Brugada syndrome. 38
31152990 2019
7
Parental Atrial Fibrillation and Stroke or Atrial Fibrillation in Young Adults. 38
31337299 2019
8
Atrial fibrillation in cryptogenic stroke and transient ischaemic attack - The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and design. 38
31259265 2019
9
Atrial fibrillation and stroke: a practical guide. 38
30826740 2019
10
Retrospecting atrial fibrillation and stroke severity: impact onset time of acute ischemic stroke. 38
31321960 2019
11
Prevalence and Significance of Interatrial Block in Takotsubo Syndrome (from the RETAKO Registry). 38
30987829 2019
12
Warfarin Dosing and Outcomes in Chronic Kidney Disease: A Closer Look at Warfarin Disposition. 38
31267868 2019
13
Small unrepaired atrial septal defects display impaired exercise capacity compared with healthy peers. 38
30582285 2019
14
Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery. 38
31087023 2019
15
Atrial Fibrillation and Stroke in Patients with Hypertrophic Cardiomyopathy: Important New Insights. 38
30759487 2019
16
Common source of miscalculation and misclassification of P-wave negativity and P-wave terminal force in lead V1. 38
30716527 2019
17
Assessment of Cardiovascular Disease Risk and Therapeutic Patterns among Urban Black Rheumatoid Arthritis Patients. 38
30791646 2019
18
Incidence, clinical features and outcomes of atrial fibrillation and stroke in Qatar. 38
30789323 2019
19
Prognostic of Interatrial Block after an Acute ST-Segment Elevation Myocardial Infarction. 38
31117073 2019
20
Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study. 38
30150122 2018
21
Reply to Green et al.-Elevated Incidence of Atrial Fibrillation and Stroke in Patients With Atrial Flutter: A Population-Based Study. 38
30170684 2018
22
Incident Atrial Fibrillation and the Risk of Stroke in Adults with Chronic Kidney Disease: The Stockholm CREAtinine Measurements (SCREAM) Project. 38
30030271 2018
23
Does Left Atrial Appendage Amputation During Routine Cardiac Surgery Reduce Future Atrial Fibrillation and Stroke? 38
30171381 2018
24
Stroke type and severity in patients with subclinical atrial fibrillation: An analysis from the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT). 38
29764671 2018
25
Atrial fibrillation and stroke: The more we learn, the less we understand. 38
29910049 2018
26
Progression of Device-Detected Subclinical Atrial Fibrillation and the Risk of Heart Failure. 38
29880119 2018
27
Atrial fibrillation and stroke prevention: where we are and where we should be. 38
29853572 2018
28
Elevated Incidence of Atrial Fibrillation and Stroke in Patients With Atrial Flutter-A Population-Based Study. 38
29801742 2018
29
Incident Atrial Fibrillation and Stroke in Patients With Atrial Flutter. 38
29729880 2018
30
Comparison of left atrial size and function in hypertrophic cardiomyopathy and in Fabry disease with left ventricular hypertrophy. 38
29457264 2018
31
[Serum albumin and cardiovascular diseases: A comprehensive review of the literature]. 38
29544976 2018
32
Subclinical device-detected atrial fibrillation and stroke risk: a systematic review and meta-analysis. 38
29340587 2018
33
Transcatheter Mitral Valve Replacement: An Alternate Treatment Methodology for Patients at High Surgical Risk. 38
29928564 2018
34
What we have learned from the European Heart Rhythm Association consensus document on device-detected subclinical atrial tachyarrhythmias. 38
29424734 2018
35
Atrial fibrillation and stroke risk factors induce decline in creatinine clearance: Is there a specific "fibrillatory kidney disease"? 38
29306477 2018
36
Usefulness of the CHA2DS2-VASc Score to Predict Outcome in Patients Who Underwent Transcatheter Aortic Valve Implantation. 38
29157734 2018
37
Abstract 4: Safety of Intravenous Thrombolysis Among Patients Taking Direct Oral Anticoagulants: A Systematic Review and Meta-analysis. 38
30520352 2018
38
The National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010): Objectives, Design, and Population Characteristics. 38
29503381 2018
39
Barriers and enablers to adherence to anticoagulation in heart failure with atrial fibrillation: patient and provider perspectives. 38
28178370 2017
40
Impact of percutaneous mitral valvuloplasty on left ventricular function in patients with mitral stenosis assessed by 3D echocardiography. 38
28712559 2017
41
Atrial fibrillation and stroke as initial manifestations of painless type A aortic dissection. 38
28803639 2017
42
Some light in the shadows of atrial fibrillation and stroke: To look or not to look. 38
28904089 2017
43
The Global Burden of Atrial Fibrillation and Stroke: A Systematic Review of the Clinical Epidemiology of Atrial Fibrillation in Asia. 38
28427968 2017
44
Management of amiodarone extravasation with intradermal hyaluronidase. 38
28947526 2017
45
Impact of pro-atrial natriuretic peptide in atrial fibrillation and stroke. 38
28452559 2017
46
Nonvitamin-K-antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and previous stroke or transient ischemic attack: An updated systematic review and meta-analysis of randomized controlled trials. 38
28730948 2017
47
Atrial cardiopathy: a mechanism of cryptogenic stroke. 38
28718666 2017
48
Cancer, atrial fibrillation, and stroke. 38
28528288 2017
49
Regulation of cardiac Ca2+ and ion channels by shear mechanotransduction. 38
28702845 2017
50
Pro-atrial natriuretic peptide and prediction of atrial fibrillation and stroke: The Malmö Preventive Project. 38
28195503 2017

Variations for Atrial Fibrillation and Stroke

Expression for Atrial Fibrillation and Stroke

Search GEO for disease gene expression data for Atrial Fibrillation and Stroke.

Pathways for Atrial Fibrillation and Stroke

GO Terms for Atrial Fibrillation and Stroke

Biological processes related to Atrial Fibrillation and Stroke according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 8.32 PDE4D

Sources for Atrial Fibrillation and Stroke

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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