MCID: ATR024
MIFTS: 22

Atrial Fibrillation and Stroke

Categories: Blood diseases, Respiratory diseases

Aliases & Classifications for Atrial Fibrillation and Stroke

MalaCards integrated aliases for Atrial Fibrillation and Stroke:

Name: Atrial Fibrillation and Stroke 53

Classifications:



Summaries for Atrial Fibrillation and Stroke

NINDS : 53 Atrial fibrillation (AF) describes the rapid, irregular beating of the left atrium (upper chamber) of the heart. These rapid contractions of the heart are weaker than normal contractions, resulting in slow flow of blood in the atrium. The blood pools and becomes sluggish and can result in the formation of blood clots. If a clot leaves the heart and travels to the brain, it can cause a stroke by blocking the flow of blood through cerebral arteries. Some people with AF have no symptoms, but others may experience a fluttering feeling in the area of the chest above the heart, chest pain, lightheadness or fainting, shortness of breath, and fatigue. AF is diagnosed by an electrocardiogram (ECG), a device that records the heart’s electrical activity. Other tests are often performed to rule out contributing causes, such as high blood pressure, an overactive thyroid gland, heart failure, faulty heart valves, lung disease, and stimulant or alcohol abuse. Some people will have no identifiable cause for their AF.

MalaCards based summary : Atrial Fibrillation and Stroke is related to cerebrovascular disease and stroke, ischemic. An important gene associated with Atrial Fibrillation and Stroke is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways is cAMP signaling pathway. The drugs Warfarin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung.

Related Diseases for Atrial Fibrillation and Stroke

Graphical network of the top 20 diseases related to Atrial Fibrillation and Stroke:



Diseases related to Atrial Fibrillation and Stroke

Symptoms & Phenotypes for Atrial Fibrillation and Stroke

Drugs & Therapeutics for Atrial Fibrillation and Stroke

Drugs for Atrial Fibrillation and Stroke (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4 81-81-2 6691 54678486
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Dabigatran Investigational Phase 4 211914-51-1
4 Anti-Inflammatory Agents Phase 4
5 Antithrombins Phase 4
6 HIV Protease Inhibitors Phase 4
7 Fibrinolytic Agents Phase 4
8
protease inhibitors Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Platelet Aggregation Inhibitors Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Antipyretics Phase 4
13 Serine Proteinase Inhibitors Phase 4
14 Cyclooxygenase Inhibitors Phase 4
15 Antirheumatic Agents Phase 4
16 Analgesics Phase 4
17 Antithrombin III Phase 4
18 Anticoagulants Phase 4
19
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
20 Nutmeg Approved
21 Mace

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial Completed NCT00256152 Phase 4
2 Effectiveness of Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Aortic and Mitral Valvular Atrial Fibrillation Patients Active, not recruiting NCT02982850 Phase 4 Dabigatran;Acetylsalicylic acid;Warfarin
3 SILENT - Subclinical AtrIal FibrilLation and StrokE PreveNtion Trial Not yet recruiting NCT02004509 Phase 4 anticoagulant by physician criteria
4 Prevalence, Severity and Natural Course of Sleep Apnea After Cardiac Surgery Unknown status NCT02632162
5 Right Apical Versus Septal Pacing Trial Unknown status NCT00199498
6 Biological Bank for Studies Related to Atrial Fibrillation and Stroke Recruiting NCT03611816
7 The Nordic Atrial Fibrillation and Stroke Study Recruiting NCT02937077
8 Fibrosis, Inflammation and Brain Health in Atrial Fibrillation. The Norwegian Atrial Fibrillation and Stroke Study Recruiting NCT03816865
9 Impact of Obstructive Sleep Apnea on Outcomes in Acute Coronary Syndrome Recruiting NCT03793582
10 Massachusetts-wide Study of the Incidence of ATrial Fibrillation and Stroke Occurring After Discharge From Cardiac Surgery (MATRICeS) Active, not recruiting NCT03466125
11 HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy Active, not recruiting NCT01915615

Search NIH Clinical Center for Atrial Fibrillation and Stroke

Genetic Tests for Atrial Fibrillation and Stroke

Anatomical Context for Atrial Fibrillation and Stroke

MalaCards organs/tissues related to Atrial Fibrillation and Stroke:

40
Heart, Brain, Lung, Testes, Thyroid, Kidney

Publications for Atrial Fibrillation and Stroke

Articles related to Atrial Fibrillation and Stroke:

(show top 50) (show all 245)
# Title Authors PMID Year
1
Atrial fibrillation and stroke: how much atrial fibrillation is enough to cause a stroke? 61
31809335 2020
2
Incident Hospitalization with Major Cardiovascular Diseases and Subsequent Risk of ESKD: Implications for Cardiorenal Syndrome. 61
31919105 2020
3
Leisure-time cross-country skiing and risk of atrial fibrillation and stroke: A prospective cohort study. 61
32013594 2020
4
Incidence, clinical features and outcomes of atrial fibrillation and stroke in Qatar. 61
30789323 2020
5
Atrial fibrillation and stroke: chicken or egg? Does it really matter? 61
31898731 2020
6
Lung function and cardiovascular disease: A link. 61
31932098 2020
7
Rhythm monitoring strategies in patients at high risk for atrial fibrillation and stroke: A comparative analysis from the REVEAL AF study. 61
31862084 2020
8
Association of Abnormal P-Wave Indices With Dementia and Cognitive Decline Over 25 Years: ARIC-NCS (The Atherosclerosis Risk in Communities Neurocognitive Study). 61
31830872 2019
9
Atrial Fibrillation and Stroke Risk in Patients With Cancer: A Primer for Oncologists. 61
31825754 2019
10
A Systematic Review of a Long-forgotten Cause of Atrial Fibrillation and Stroke: Cor Triatriatum. 61
31938652 2019
11
Assessment of cardiac biomarkers (troponin, B-type natriuretic peptide, and D-dimer) in patients with non-valvular atrial fibrillation and stroke. 61
31745392 2019
12
E-noise: An increasingly relevant health risk. 61
31362866 2019
13
Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation-A report from the CHART-2 Study. 61
31104823 2019
14
Prevalence of atrial fibrillation and stroke risk assessment based on telemedicine screening tools in a primary healthcare setting. 61
31320151 2019
15
Atrial Fibrillation and Stroke. A Review on the Use of Vitamin K Antagonists and Novel Oral Anticoagulants. 61
31547188 2019
16
Long-Term Incidence of Atrial Fibrillation and Stroke Among Cross-Country Skiers. 61
31446766 2019
17
Parental Atrial Fibrillation and Stroke or Atrial Fibrillation in Young Adults. 61
31337299 2019
18
Association of Antihyperglycemic Therapy with Risk of Atrial Fibrillation and Stroke in Diabetic Patients. 61
31540142 2019
19
Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study. 61
31449466 2019
20
Postoperative Atrial Fibrillation Following Noncardiac Surgery Increases Risk of Stroke. 61
31473150 2019
21
Short lookback periods causing exaggerated stroke risk estimates in atrial fibrillation may expose patients to unnecessary anticoagulant treatment. 61
31112361 2019
22
Advanced interatrial block is a surrogate for left atrial strain reduction which predicts atrial fibrillation and stroke. 61
30719798 2019
23
Electrocardiographic evidence of abnormal atrial phenotype in Brugada syndrome. 61
31152990 2019
24
Atrial fibrillation in cryptogenic stroke and transient ischaemic attack - The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and design. 61
31259265 2019
25
Retrospecting atrial fibrillation and stroke severity: impact onset time of acute ischemic stroke. 61
31321960 2019
26
Atrial fibrillation and stroke: a practical guide. 61
30826740 2019
27
Prevalence and Significance of Interatrial Block in Takotsubo Syndrome (from the RETAKO Registry). 61
30987829 2019
28
Small unrepaired atrial septal defects display impaired exercise capacity compared with healthy peers. 61
30582285 2019
29
Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery. 61
31087023 2019
30
Atrial Fibrillation and Stroke in Patients with Hypertrophic Cardiomyopathy: Important New Insights. 61
30759487 2019
31
Common source of miscalculation and misclassification of P-wave negativity and P-wave terminal force in lead V1. 61
30716527 2019
32
Assessment of Cardiovascular Disease Risk and Therapeutic Patterns among Urban Black Rheumatoid Arthritis Patients. 61
30791646 2019
33
Prognostic of Interatrial Block after an Acute ST-Segment Elevation Myocardial Infarction. 61
31117073 2019
34
Warfarin Dosing and Outcomes in Chronic Kidney Disease: A Closer Look at Warfarin Disposition. 61
31267868 2019
35
Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study. 61
30150122 2018
36
Incident Atrial Fibrillation and the Risk of Stroke in Adults with Chronic Kidney Disease: The Stockholm CREAtinine Measurements (SCREAM) Project. 61
30030271 2018
37
Reply to Green et al.-Elevated Incidence of Atrial Fibrillation and Stroke in Patients With Atrial Flutter: A Population-Based Study. 61
30170684 2018
38
Does Left Atrial Appendage Amputation During Routine Cardiac Surgery Reduce Future Atrial Fibrillation and Stroke? 61
30171381 2018
39
Atrial fibrillation and stroke: The more we learn, the less we understand. 61
29910049 2018
40
Stroke type and severity in patients with subclinical atrial fibrillation: An analysis from the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT). 61
29764671 2018
41
Elevated Incidence of Atrial Fibrillation and Stroke in Patients With Atrial Flutter-A Population-Based Study. 61
29801742 2018
42
Incident Atrial Fibrillation and Stroke in Patients With Atrial Flutter. 61
29729880 2018
43
Progression of Device-Detected Subclinical Atrial Fibrillation and the Risk of Heart Failure. 61
29880119 2018
44
Atrial fibrillation and stroke prevention: where we are and where we should be. 61
29853572 2018
45
Comparison of left atrial size and function in hypertrophic cardiomyopathy and in Fabry disease with left ventricular hypertrophy. 61
29457264 2018
46
Subclinical device-detected atrial fibrillation and stroke risk: a systematic review and meta-analysis. 61
29340587 2018
47
[Serum albumin and cardiovascular diseases: A comprehensive review of the literature]. 61
29544976 2018
48
Transcatheter Mitral Valve Replacement: An Alternate Treatment Methodology for Patients at High Surgical Risk. 61
29928564 2018
49
What we have learned from the European Heart Rhythm Association consensus document on device-detected subclinical atrial tachyarrhythmias. 61
29424734 2018
50
Atrial fibrillation and stroke risk factors induce decline in creatinine clearance: Is there a specific "fibrillatory kidney disease"? 61
29306477 2018

Variations for Atrial Fibrillation and Stroke

Expression for Atrial Fibrillation and Stroke

Search GEO for disease gene expression data for Atrial Fibrillation and Stroke.

Pathways for Atrial Fibrillation and Stroke

Pathways related to Atrial Fibrillation and Stroke according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 PDE4D NPPA

GO Terms for Atrial Fibrillation and Stroke

Sources for Atrial Fibrillation and Stroke

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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