Atrial Fibrillation, Familial, 4 (ATFB4)

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OMIM 57 611493 MedGen 42 C1862394 MeSH 44 D001281

SNOMED-CT via HPO 69 263681008 80313002 426749004 440028005 282825002 284470004 287057009 406461004 63593006 more UMLS 73 C1862394

OMIM : ⁵⁷ Atrial fibrillation is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997). For a discussion of genetic heterogeneity of atrial fibrillation, see 608583. (611493)

MalaCards based summary : Atrial Fibrillation, Familial, 4, also known as atfb4, is related to long qt syndrome 6 and familial atrial fibrillation. An important gene associated with Atrial Fibrillation, Familial, 4 is KCNE2 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 2). Affiliated tissues include heart, and related phenotypes are palpitations and paroxysmal atrial fibrillation

UniProtKB/Swiss-Prot : ⁷⁵ Atrial fibrillation, familial, 4: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Clinical features from OMIM:

611493

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