MCID: ATR055
MIFTS: 25

Atrial Septal Aneurysm

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Atrial Septal Aneurysm

MalaCards integrated aliases for Atrial Septal Aneurysm:

Name: Atrial Septal Aneurysm 58 71

Classifications:

Orphanet: 58  
Rare cardiac malformations
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 Q21.1
UMLS via Orphanet 72 C0521533
Orphanet 58 ORPHA99107
UMLS 71 C0521533

Summaries for Atrial Septal Aneurysm

MalaCards based summary : Atrial Septal Aneurysm is related to aneurysm and patent foramen ovale. The drugs Coagulants and Anticoagulants have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and cerebellum.

Related Diseases for Atrial Septal Aneurysm

Diseases related to Atrial Septal Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 aneurysm 12.0
2 patent foramen ovale 11.9
3 atrial heart septal defect 11.8
4 heart septal defect 10.8
5 orthostatic intolerance 10.7
6 stroke, ischemic 10.5
7 intracranial embolism 10.5
8 transient cerebral ischemia 10.5
9 pulmonary embolism 10.4
10 interatrial communication 10.4
11 migraine with or without aura 1 10.4
12 atrial fibrillation 10.4
13 progressive familial heart block, type ia 10.3
14 mitral valve stenosis 10.3
15 progressive familial heart block, type ib 10.3
16 migraine with aura 10.3
17 right bundle branch block 10.3
18 thrombophilia due to thrombin defect 10.2
19 pulmonary hypertension 10.2
20 mitral valve insufficiency 10.2
21 ventricular septal defect 10.2
22 congestive heart failure 10.2
23 supravalvular aortic stenosis 10.1
24 hypoplastic right heart syndrome 10.1
25 endocarditis 10.1
26 dilated cardiomyopathy 10.1
27 thrombophilia 10.1
28 ischemia 10.1
29 restrictive cardiomyopathy 10.1
30 kidney disease 10.1
31 mitral valve disease 10.1
32 cerebrovascular disease 10.1
33 cor triatriatum 10.1
34 atrial standstill 1 10.0
35 cardiac arrhythmia 10.0
36 cardiac conduction defect 10.0
37 hypercholesterolemia, familial, 1 10.0
38 juvenile polyposis syndrome 10.0
39 thrombophilia due to activated protein c resistance 10.0
40 wolff-parkinson-white syndrome 10.0
41 cutis marmorata telangiectatica congenita 10.0
42 pseudoxanthoma elasticum 10.0
43 pulmonary arteriovenous fistulas 10.0
44 tricuspid atresia 10.0
45 patent ductus arteriosus 1 10.0
46 cyanosis, transient neonatal 10.0
47 atrial septal defect 3 10.0
48 atrioventricular block 10.0
49 aphasia 10.0
50 polycystic kidney disease 10.0

Graphical network of the top 20 diseases related to Atrial Septal Aneurysm:



Diseases related to Atrial Septal Aneurysm

Symptoms & Phenotypes for Atrial Septal Aneurysm

Drugs & Therapeutics for Atrial Septal Aneurysm

Drugs for Atrial Septal Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Coagulants Phase 4
2 Anticoagulants Phase 4
3
Rivaroxaban Approved Phase 3 366789-02-8
4
Apixaban Approved Phase 3 503612-47-3 10182969
5
Dipyridamole Approved Phase 3 58-32-2 3108
6
Dabigatran Investigational Phase 3 211914-51-1
7 Antithrombins Phase 3
8 Antithrombin III Phase 3
9 Serine Proteinase Inhibitors Phase 3
10 Phosphodiesterase Inhibitors Phase 3
11
protease inhibitors Phase 3
12 Factor Xa Inhibitors Phase 3
13 Vasodilator Agents Phase 3
14 HIV Protease Inhibitors Phase 3
15 Aspirin, Dipyridamole Drug Combination Phase 3
16 Antivitamins K Phase 3
17
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
18
Clopidogrel Approved 113665-84-2, 120202-66-6 60606
19
Aspirin Approved, Vet_approved 50-78-2 2244
20 Neurotransmitter Agents
21 Fibrinolytic Agents
22 Analgesics, Non-Narcotic
23 Purinergic P2Y Receptor Antagonists
24 Analgesics
25 Cyclooxygenase Inhibitors
26 Platelet Aggregation Inhibitors
27 Anti-Inflammatory Agents
28 Antipyretics
29 Antirheumatic Agents
30 Anti-Inflammatory Agents, Non-Steroidal
31 Calamus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Device Closure Versus Medical Therapy for Secondary Prevention in Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale : DEFENSE-PFO Unknown status NCT01550588 Phase 4 Standard medical treatment
2 Interventional Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in High-risk Patients With Atrial Fibrillation (PRAGUE-17 Study) Recruiting NCT02426944 Phase 4 NOAC
3 Closure of Patent Foramen Ovale or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence Completed NCT00562289 Phase 3 aspirin;Antivitamins K or rivaroxaban or dabigatran or apixaban
4 Prospective Clinical Follow-up of Patients Presenting With Cryptogenic Stroke Treated With the Percutaneous Closure of a Patent Foramen Ovale Unknown status NCT01149447
5 Prospective, Open-label, Multicenter, Non-randomized Investigation on Percutaneous Patent Foramen Ovale (PFO) Closure Using the Occlutech PFO Occluder to Prevent Recurrence of Stroke in Patients With Cryptogenic Stroke and High Risk PFO Recruiting NCT04029233
6 Secondary Stroke Prevention In Patients With Patent Foramen Ovale: International PFO Consortium Recruiting NCT00859885 Antithrombotic treatment
7 A Pilot Randomized Controlled Trial of Maternal Oxygen Therapy for Fetal Left Heart Hypoplasia Recruiting NCT02965638
8 Suture Mediated Septal Defect Closure/Repair Evaluation of the NobleStitch EL System Enrolling by invitation NCT03373929

Search NIH Clinical Center for Atrial Septal Aneurysm

Genetic Tests for Atrial Septal Aneurysm

Anatomical Context for Atrial Septal Aneurysm

MalaCards organs/tissues related to Atrial Septal Aneurysm:

40
Heart, Brain, Cerebellum, Retina, Kidney, Skin, Neutrophil

Publications for Atrial Septal Aneurysm

Articles related to Atrial Septal Aneurysm:

(show top 50) (show all 723)
# Title Authors PMID Year
1
Transseptal occluder migration after transcatheter atrial septal aneurysm and double secondary septal defect correction: A case report. 61
32566068 2020
2
Association between atrial septal aneurysm and arrhythmias. 61
31544553 2020
3
Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence: A Prospective Cohort Study. 61
32422058 2020
4
Cardiovascular MRI: A valuable tool to detect cardiac source of emboli in cryptogenic ischemic strokes. 61
32304360 2020
5
Atrial Septal Aneurysm, Shunt Size, and Recurrent Stroke Risk in Patients With Patent Foramen Ovale. 61
32381162 2020
6
Acute cerebral infarction with acute myocardial infarction due to patent foramen ovale: A case report. 61
32384468 2020
7
Patent foramen ovale. 61
32299831 2020
8
Correlations between serum homocysteine levels and RoPE score in patients with patent foramen ovale. 61
31676957 2020
9
[Isolated atrial septal aneurysm: Exceptional cause of digital ischemia - a case report]. 61
32222284 2020
10
Atrial septal aneurysm in pregnancy: echocardiography and obstetric outcomes. 61
32134736 2020
11
[Patent foramen ovale with a license to kill]. 61
30859250 2020
12
Simultaneous Multifocal Paradoxical Embolism in an Elderly Patient with Patent Foramen Ovale: A Case Report. 61
32206456 2020
13
Patent foramen ovale and stroke: current evidence and treatment options. 61
31789709 2020
14
Screening and evaluation of newly diagnosed cardiovascular diseases in first-trimester asymptomatic pregnant women in a tertiary antenatal care center in Turkey. 61
32011322 2020
15
A giant atrial septal aneurysm causing tricuspid valvular obstruction. 61
31930731 2020
16
Study of transesophageal echocardiography in young patients (<40 years) with acute arterial ischemic stroke: A pilot study. 61
32020968 2020
17
Morphometric Features of Patent Foramen Ovale as a Risk Factor of Cerebrovascular Accidents: A Systematic Review and Meta-Analysis. 61
32097931 2020
18
Reprint of : Transcatheter closure of patent foramen ovale to prevent stroke recurrence in patients with otherwise unexplained ischaemic stroke: Expert consensus of the French Neurovascular Society and the French Society of Cardiology. 61
31787326 2020
19
Fetal atrial septal aneurysm: a differential diagnosis of aortic arch retrograde flow. 61
31969409 2020
20
'Windsock' type atrial septal aneurysm in an adult causing paradoxical embolism. 61
32463106 2020
21
An atrial septal aneurysm with an organized thrombus in an asymptomatic patient: A case report. 61
31770224 2019
22
Is there any association between rs1303 (Pi*M3) variant of alpha-1 antitrypsin gene and atrial septal aneurysm development? 61
31523846 2019
23
Patent foramen ovale closure versus medical therapy for cryptogenic stroke: An updated systematic review and meta-analysis. 61
32248916 2019
24
Left atrial enlargement as a maker of significant high-risk patent foramen ovale. 61
31325066 2019
25
Stroke in the Young: a Global Update. 61
31768660 2019
26
Role of 3D transesophageal echocardiography in transcatheter closure of atrial septal aneurysms. 61
31541598 2019
27
Frugal innovation in the cardiac catheter laboratory: Retrograde balloon mitral valvuloplasty using extra back-up guide catheter. 61
31497174 2019
28
Long-Term Outcome After Percutaneous Closure of Patent Foramen Ovale for Cryptogenic Ischemic Events. 61
31368895 2019
29
Transcatheter closure of patent foramen ovale to prevent stroke recurrence in patients with otherwise unexplained ischaemic stroke: Expert consensus of the French Neurovascular Society and the French Society of Cardiology. 61
31378692 2019
30
Identification of High-Risk Patent Foramen Ovale Associated With Cryptogenic Stroke: Development of a Scoring System. 61
31130417 2019
31
Cutis marmorata in decompression sickness is associated with a patent foramen ovale. 61
31087401 2019
32
Atrial septal aneurysm with rare comorbid pulmonary arteriovenous malformation as aetiology for cryptogenic stroke. 61
31248896 2019
33
Insertable cardiac monitor detection of silent atrial fibrillation in candidates for percutaneous patent foramen ovale closure. 61
30921267 2019
34
Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated meta-analysis of randomized trials. 61
31110604 2019
35
Cardioembolic Sources in Patients With Small Single Subcortical Infarcts. 61
30817491 2019
36
Updated meta-analysis of closure of patent foramen ovale versus medical therapy after cryptogenic stroke. 61
30905408 2019
37
Management of Patients with Patent Foramen Ovale and Cryptogenic Stroke: An Update. 61
31307049 2019
38
Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study. 61
31061729 2019
39
Are we there yet with patent foramen ovale closure for secondary prevention in cryptogenic stroke? A systematic review and meta-analysis of randomized trials. 61
30783525 2019
40
A Proposed Etiology for Atrial Tachyarrhythmia in Neonates with Atrial Septal Aneurysms. 61
30426160 2019
41
Current management aspects in adult congenital heart disease: non-surgical closure of patent foramen ovale. 61
30740321 2018
42
Clinical relevance of atrial septal aneurysm and patent foramen ovale with migraine. 61
30568946 2018
43
Electrocardiography-gated dual-source computed tomography in the detection of atrial septal aneurysm. 61
30402163 2018
44
Giant atrial septal aneurysm prolapsing into the right ventricle in an asymptomatic infant. 61
30391977 2018
45
Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies. 61
29804325 2018
46
Interatrial shunts: technical approaches to percutaneous closure. 61
30246569 2018
47
Updated Meta-analysis on the Closure of Patent Foramen Ovale in Reduction of Stroke Rates: the DEFENSE-PFO Trial Does not Change the Scenario. 61
30517261 2018
48
Is Patent Foramen Ovale Closure More Effective Than Medical Therapy in Preventing Stroke Recurrence in Patients With Cryptogenic Stroke?: A Critically Appraised Topic. 61
30169372 2018
49
[Patent foramen ovale-intervention or pharmaceutical treatment]. 61
29978350 2018
50
Patent foramen ovale and stroke. 61
29680895 2018

Variations for Atrial Septal Aneurysm

ClinVar genetic disease variations for Atrial Septal Aneurysm:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RNF213 NM_001256071.3(RNF213):c.11659A>G (p.Lys3887Glu)SNV Uncertain significance 523426 rs1555673862 17:78337499-78337499 17:80363699-80363699

Expression for Atrial Septal Aneurysm

Search GEO for disease gene expression data for Atrial Septal Aneurysm.

Pathways for Atrial Septal Aneurysm

GO Terms for Atrial Septal Aneurysm

Sources for Atrial Septal Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....