MCID: ATR048
MIFTS: 39

Atrial Tachyarrhythmia with Short Pr Interval

Categories: Rare diseases

Aliases & Classifications for Atrial Tachyarrhythmia with Short Pr Interval

MalaCards integrated aliases for Atrial Tachyarrhythmia with Short Pr Interval:

Name: Atrial Tachyarrhythmia with Short Pr Interval 57 12 59
Lown-Ganong-Levine Syndrome 12 59 44 15 73
Syndrome of Short P-R Interval, Normal Qrs Complexes, and Supraventricular Tachycardias 12
Lgl Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
lown-ganong-levine syndrome
Inheritance: Autosomal dominant,Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
atrial tachyarrhythmia with short pr interval:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 108950
Disease Ontology 12 DOID:13087
ICD10 33 I45.6
ICD9CM 35 426.81
MeSH 44 D008151
SNOMED-CT 68 55475008
Orphanet 59 ORPHA844
UMLS via Orphanet 74 C1862387 C0024054
ICD10 via Orphanet 34 I45.6
MedGen 42 C1862387
UMLS 73 C0024054

Summaries for Atrial Tachyarrhythmia with Short Pr Interval

Disease Ontology : 12 A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles.

MalaCards based summary : Atrial Tachyarrhythmia with Short Pr Interval, also known as lown-ganong-levine syndrome, is related to progressive familial heart block, type ia and progressive familial heart block, type ib. An important gene associated with Atrial Tachyarrhythmia with Short Pr Interval is RORA (RAR Related Orphan Receptor A), and among its related pathways/superpathways are Cellular senescence (KEGG) and Phagosome. Affiliated tissues include heart, lung and tongue, and related phenotypes are shortened pr interval and paroxysmal atrial tachycardia

Description from OMIM: 108950

Related Diseases for Atrial Tachyarrhythmia with Short Pr Interval

Diseases related to Atrial Tachyarrhythmia with Short Pr Interval via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ia 10.7
2 progressive familial heart block, type ib 10.5
3 left ventricular noncompaction 10.5
4 right bundle branch block 10.5
5 hypertrophic cardiomyopathy 10.5
6 phenytoin or carbamazepine toxicity 9.9 HLA-B HLA-A
7 postherpetic neuralgia 9.9 HLA-B HLA-A
8 pars planitis 9.9 HLA-B HLA-A
9 pityriasis rosea 9.9 HLA-B HLA-A
10 anterior uveitis 9.9 HLA-B HLA-A
11 chronic pyelonephritis 9.9 HLA-B HLA-A
12 nontuberculous mycobacterial lung disease 9.9 HLA-B HLA-A
13 human herpesvirus 8 9.9 HLA-B HLA-A
14 idiopathic bronchiectasis 9.9 HLA-B HLA-A
15 histoplasmosis 9.9 HLA-B HLA-A
16 pure red-cell aplasia 9.9 HLA-B HLA-A
17 cytomegalovirus retinitis 9.9 HLA-B HLA-A
18 alveolar echinococcosis 9.9 HLA-B HLA-A
19 glaucomatocyclitic crisis 9.9 HLA-B HLA-A
20 hematopoietic stem cell transplantation 9.9 HLA-B HLA-A
21 geographic tongue 9.9 HLA-B HLA-A
22 panuveitis 9.9 HLA-B HLA-A
23 separation anxiety disorder 9.9 HLA-B HLA-A
24 stevens-johnson syndrome/toxic epidermal necrolysis 9.9 HLA-B HLA-A
25 aphthous stomatitis 9.9 HLA-B HLA-A
26 paraneoplastic pemphigus 9.9 HLA-B HLA-A
27 herpes zoster 9.9 HLA-B HLA-A
28 spondyloarthropathy 9.9 HLA-B HLA-A
29 dengue hemorrhagic fever 9.9 HLA-B HLA-A
30 vogt-koyanagi-harada disease 9.9 HLA-B HLA-A
31 severe cutaneous adverse reaction 9.9 HLA-B HLA-A
32 rubella 9.9 HLA-B HLA-A
33 takayasu arteritis 9.8 HLA-B HLA-A
34 cytomegalovirus infection 9.8 HLA-B HLA-A
35 mitochondrial metabolism disease 9.8 NDUFA6 MT-ND4
36 graft-versus-host disease 9.8 HLA-B HLA-A
37 melanoma, uveal 9.8 HLA-B HLA-A
38 behcet syndrome 9.7 HLA-B HLA-A

Comorbidity relations with Atrial Tachyarrhythmia with Short Pr Interval via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation

Graphical network of the top 20 diseases related to Atrial Tachyarrhythmia with Short Pr Interval:



Diseases related to Atrial Tachyarrhythmia with Short Pr Interval

Symptoms & Phenotypes for Atrial Tachyarrhythmia with Short Pr Interval

Symptoms via clinical synopsis from OMIM:

57
Cardiac:
paroxysmal atrial tachycardia
paroxysmal or chronic atrial fibrillation

Lab:
electrocardiographic short pr interval


Clinical features from OMIM:

108950

Human phenotypes related to Atrial Tachyarrhythmia with Short Pr Interval:

32
# Description HPO Frequency HPO Source Accession
1 shortened pr interval 32 HP:0005165
2 paroxysmal atrial tachycardia 32 HP:0006671
3 paroxysmal atrial fibrillation 32 HP:0004757
4 permanent atrial fibrillation 32 HP:0004754

GenomeRNAi Phenotypes related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.36 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.36 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.36 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.36 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.36 HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.36 HLA-A HLA-B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.36 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.36 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.36 HLA-A HLA-B

Drugs & Therapeutics for Atrial Tachyarrhythmia with Short Pr Interval

Search Clinical Trials , NIH Clinical Center for Atrial Tachyarrhythmia with Short Pr Interval

Cochrane evidence based reviews: lown-ganong-levine syndrome

Genetic Tests for Atrial Tachyarrhythmia with Short Pr Interval

Anatomical Context for Atrial Tachyarrhythmia with Short Pr Interval

MalaCards organs/tissues related to Atrial Tachyarrhythmia with Short Pr Interval:

41
Heart, Lung, Tongue

Publications for Atrial Tachyarrhythmia with Short Pr Interval

Articles related to Atrial Tachyarrhythmia with Short Pr Interval:

(show all 27)
# Title Authors Year
1
A Case of Lown-Ganong-Levine Syndrome: Due to an Accessory Pathway of James Fibers or Enhanced Atrioventricular Nodal Conduction (EAVNC)? ( 29550833 )
2018
2
Anaesthetic management of a patient with Lown Ganong Levine syndrome-a case report. ( 27365828 )
2011
3
Lown-Ganong-Levine syndrome in a 3-month-old infant with isolated left ventricular noncompaction. ( 19859765 )
2010
4
Lown-Ganong-Levine syndrome in pregnancy. ( 14662232 )
2003
5
Enhanced A-V nodal conduction (Lown-Ganong-Levine syndrome) by congenitally hypoplastic A-V node. ( 1464347 )
1992
6
Supraventricular tachycardia in a patient with Lown-Ganong-Levine syndrome associated with apical hypertrophic cardiomyopathy. ( 3398258 )
1988
7
Lown-Ganong-Levine syndrome. ( 3269321 )
1988
8
Intrauterine supraventricular tachycardia with a familial history of Lown-Ganong-Levine syndrome. ( 3774583 )
1986
9
Multifocal Purkinje-like tumor of the heart. Occurrence with other anatomic abnormalities in the atrioventricular junction of an infant with junctional tachycardia, Lown-Ganong-Levine syndrome, and sudden death. ( 3971758 )
1985
10
Mechanisms of junctional tachycardias in the Lown-Ganong-Levine syndrome. ( 6849236 )
1983
11
Lown-Ganong-Levine syndrome associated with Mahaim nodoventricular fibers. ( 15227113 )
1983
12
The Lown-Ganong-Levine syndrome. ( 6182544 )
1982
13
Analysis of anterograde and retrograde fast pathway properties in patients with dual atrioventricular nodal pathways: observations regarding the pathophysiology of the Lown-Ganong-Levine syndrome. ( 7058743 )
1982
14
How to spot...and care for...the patient with Lown-Ganong-Levine syndrome. ( 6907768 )
1981
15
Cycle length in atrioventricular nodal reentrant paroxysmal tachycardia with observations on the Lown-Ganong-Levine syndrome. ( 7377112 )
1980
16
Atrial depolarization in Wolf-Parkinson-White and Lown-Ganong-Levine syndrome: vectorcardiographic features. ( 156108 )
1979
17
Electrocardiograms of the month: Lown-Ganong-Levine syndrome and right bundle-branch block. ( 287918 )
1979
18
Lown-Ganong-Levine syndrome. ( 679452 )
1978
19
Abnormalities of atrioventricular conduction in patients with the Lown-Ganong-Levine syndrome. ( 747919 )
1978
20
Characteristics of atrioventricular conduction and the spectrum of arrhythmias in lown-ganong-levine syndrome. ( 624155 )
1978
21
Supraventricular tachycardia in Lown-Ganong-Levine syndrome: atrionodal versus intranodal reentry. ( 910716 )
1977
22
Familial atrial tachyarrhythmia with short PR interval. ( 836114 )
1977
23
Intermittent bundle-branch block in patients with accessory atrio-His or atrio-AV nodal pathways. Variants of the Lown-Ganong-Levine syndrome. ( 1259830 )
1976
24
Demonstration of dual A-V pathways in a patient with Lown-Ganong-Levine syndrome. ( 4813840 )
1974
25
Lown-Ganong-Levine syndrome. ( 5020803 )
1972
26
Taboparesis: Lown-Ganong-Levine syndrome. ( 5035914 )
1972
27
Lown-Ganong-Levine syndrome. A study using His bundle electrograms. ( 5094149 )
1971

Variations for Atrial Tachyarrhythmia with Short Pr Interval

Expression for Atrial Tachyarrhythmia with Short Pr Interval

Search GEO for disease gene expression data for Atrial Tachyarrhythmia with Short Pr Interval.

Pathways for Atrial Tachyarrhythmia with Short Pr Interval

Pathways related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.53 HLA-A HLA-B
2 11.44 HLA-A HLA-B
3 11.31 HLA-A HLA-B
4 11.09 HLA-A HLA-B
5 10.02 HLA-A HLA-B

GO Terms for Atrial Tachyarrhythmia with Short Pr Interval

Cellular components related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial membrane GO:0031966 9.43 MT-ND4 NDUFA6
2 early endosome membrane GO:0031901 9.4 HLA-A HLA-B
3 recycling endosome membrane GO:0055038 9.37 HLA-A HLA-B
4 phagocytic vesicle membrane GO:0030670 9.32 HLA-A HLA-B
5 ER to Golgi transport vesicle membrane GO:0012507 9.26 HLA-A HLA-B
6 mitochondrial respiratory chain complex I GO:0005747 9.16 MT-ND4 NDUFA6
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-A HLA-B
8 MHC class I protein complex GO:0042612 8.62 HLA-A HLA-B

Biological processes related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.49 HLA-A HLA-B
2 type I interferon signaling pathway GO:0060337 9.48 HLA-A HLA-B
3 mitochondrial respiratory chain complex I assembly GO:0032981 9.46 MT-ND4 NDUFA6
4 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.43 MT-ND4 NDUFA6
5 antigen processing and presentation GO:0019882 9.4 HLA-A HLA-B
6 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.37 HLA-A HLA-B
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.32 HLA-A HLA-B
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.26 HLA-A HLA-B
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.16 HLA-A HLA-B
10 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 8.96 HLA-A HLA-B
11 protection from natural killer cell mediated cytotoxicity GO:0042270 8.62 HLA-A HLA-B

Molecular functions related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.96 MT-ND4 NDUFA6
2 peptide antigen binding GO:0042605 8.62 HLA-A HLA-B

Sources for Atrial Tachyarrhythmia with Short Pr Interval

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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