MCID: ATR048
MIFTS: 34

Atrial Tachyarrhythmia with Short Pr Interval

Categories: Rare diseases

Aliases & Classifications for Atrial Tachyarrhythmia with Short Pr Interval

MalaCards integrated aliases for Atrial Tachyarrhythmia with Short Pr Interval:

Name: Atrial Tachyarrhythmia with Short Pr Interval 57 12 59
Lown-Ganong-Levine Syndrome 12 59 44 15 73
Syndrome of Short P-R Interval, Normal Qrs Complexes, and Supraventricular Tachycardias 12
Lgl Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
lown-ganong-levine syndrome
Inheritance: Autosomal dominant,Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
atrial tachyarrhythmia with short pr interval:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 108950
Disease Ontology 12 DOID:13087
ICD10 33 I45.6
ICD9CM 35 426.81
MeSH 44 D008151
SNOMED-CT 68 55475008
Orphanet 59 ORPHA844
UMLS via Orphanet 74 C1862387 C0024054
ICD10 via Orphanet 34 I45.6
MedGen 42 C1862387
UMLS 73 C0024054

Summaries for Atrial Tachyarrhythmia with Short Pr Interval

Disease Ontology : 12 A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles.

MalaCards based summary : Atrial Tachyarrhythmia with Short Pr Interval, also known as lown-ganong-levine syndrome, is related to progressive familial heart block, type ia and progressive familial heart block, type ib. An important gene associated with Atrial Tachyarrhythmia with Short Pr Interval is RORA (RAR Related Orphan Receptor A), and among its related pathways/superpathways are Cellular senescence (KEGG) and Phagosome. Affiliated tissues include heart, and related phenotypes are permanent atrial fibrillation and paroxysmal atrial fibrillation

Description from OMIM: 108950

Related Diseases for Atrial Tachyarrhythmia with Short Pr Interval

Diseases related to Atrial Tachyarrhythmia with Short Pr Interval via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ia 10.5
2 progressive familial heart block, type ib 10.4
3 left ventricular noncompaction 10.4
4 hypertrophic cardiomyopathy 10.4
5 right bundle branch block 10.4
6 phenytoin or carbamazepine toxicity 9.8 HLA-A HLA-B
7 postherpetic neuralgia 9.8 HLA-A HLA-B
8 glaucomatocyclitic crisis 9.8 HLA-A HLA-B
9 pars planitis 9.8 HLA-A HLA-B
10 anterior uveitis 9.8 HLA-A HLA-B
11 pityriasis rosea 9.8 HLA-A HLA-B
12 chronic pyelonephritis 9.8 HLA-A HLA-B
13 human herpesvirus 8 9.7 HLA-A HLA-B
14 nontuberculous mycobacterial lung disease 9.7 HLA-A HLA-B
15 idiopathic bronchiectasis 9.7 HLA-A HLA-B
16 histoplasmosis 9.7 HLA-A HLA-B
17 alveolar echinococcosis 9.7 HLA-A HLA-B
18 pure red-cell aplasia 9.7 HLA-A HLA-B
19 hematopoietic stem cell transplantation 9.7 HLA-A HLA-B
20 separation anxiety disorder 9.7 HLA-A HLA-B
21 geographic tongue 9.6 HLA-A HLA-B
22 aphthous stomatitis 9.6 HLA-A HLA-B
23 paraneoplastic pemphigus 9.6 HLA-A HLA-B
24 spondyloarthropathy 9.6 HLA-A HLA-B
25 vogt-koyanagi-harada disease 9.6 HLA-A HLA-B
26 severe cutaneous adverse reaction 9.5 HLA-A HLA-B
27 rubella 9.5 HLA-A HLA-B
28 takayasu arteritis 9.4 HLA-A HLA-B
29 graft-versus-host disease 9.3 HLA-A HLA-B
30 melanoma, uveal 9.2 HLA-A HLA-B
31 behcet syndrome 9.0 HLA-A HLA-B

Comorbidity relations with Atrial Tachyarrhythmia with Short Pr Interval via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation

Graphical network of the top 20 diseases related to Atrial Tachyarrhythmia with Short Pr Interval:



Diseases related to Atrial Tachyarrhythmia with Short Pr Interval

Symptoms & Phenotypes for Atrial Tachyarrhythmia with Short Pr Interval

Symptoms via clinical synopsis from OMIM:

57
Lab:
electrocardiographic short pr interval

Cardiac:
paroxysmal or chronic atrial fibrillation
paroxysmal atrial tachycardia


Clinical features from OMIM:

108950

Human phenotypes related to Atrial Tachyarrhythmia with Short Pr Interval:

32
# Description HPO Frequency HPO Source Accession
1 permanent atrial fibrillation 32 HP:0004754
2 paroxysmal atrial fibrillation 32 HP:0004757
3 shortened pr interval 32 HP:0005165
4 paroxysmal atrial tachycardia 32 HP:0006671

GenomeRNAi Phenotypes related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.36 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.36 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.36 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.36 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.36 HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.36 HLA-A HLA-B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.36 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.36 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.36 HLA-A HLA-B

Drugs & Therapeutics for Atrial Tachyarrhythmia with Short Pr Interval

Search Clinical Trials , NIH Clinical Center for Atrial Tachyarrhythmia with Short Pr Interval

Cochrane evidence based reviews: lown-ganong-levine syndrome

Genetic Tests for Atrial Tachyarrhythmia with Short Pr Interval

Anatomical Context for Atrial Tachyarrhythmia with Short Pr Interval

MalaCards organs/tissues related to Atrial Tachyarrhythmia with Short Pr Interval:

41
Heart

Publications for Atrial Tachyarrhythmia with Short Pr Interval

Articles related to Atrial Tachyarrhythmia with Short Pr Interval:

(show all 26)
# Title Authors Year
1
Anaesthetic management of a patient with Lown Ganong Levine syndrome-a case report. ( 27365828 )
2011
2
Lown-Ganong-Levine syndrome in a 3-month-old infant with isolated left ventricular noncompaction. ( 19859765 )
2010
3
Lown-Ganong-Levine syndrome in pregnancy. ( 14662232 )
2003
4
Enhanced A-V nodal conduction (Lown-Ganong-Levine syndrome) by congenitally hypoplastic A-V node. ( 1464347 )
1992
5
Supraventricular tachycardia in a patient with Lown-Ganong-Levine syndrome associated with apical hypertrophic cardiomyopathy. ( 3398258 )
1988
6
Lown-Ganong-Levine syndrome. ( 3269321 )
1988
7
Intrauterine supraventricular tachycardia with a familial history of Lown-Ganong-Levine syndrome. ( 3774583 )
1986
8
Multifocal Purkinje-like tumor of the heart. Occurrence with other anatomic abnormalities in the atrioventricular junction of an infant with junctional tachycardia, Lown-Ganong-Levine syndrome, and sudden death. ( 3971758 )
1985
9
Mechanisms of junctional tachycardias in the Lown-Ganong-Levine syndrome. ( 6849236 )
1983
10
Lown-Ganong-Levine syndrome associated with Mahaim nodoventricular fibers. ( 15227113 )
1983
11
The Lown-Ganong-Levine syndrome. ( 6182544 )
1982
12
Analysis of anterograde and retrograde fast pathway properties in patients with dual atrioventricular nodal pathways: observations regarding the pathophysiology of the Lown-Ganong-Levine syndrome. ( 7058743 )
1982
13
How to spot...and care for...the patient with Lown-Ganong-Levine syndrome. ( 6907768 )
1981
14
Cycle length in atrioventricular nodal reentrant paroxysmal tachycardia with observations on the Lown-Ganong-Levine syndrome. ( 7377112 )
1980
15
Atrial depolarization in Wolf-Parkinson-White and Lown-Ganong-Levine syndrome: vectorcardiographic features. ( 156108 )
1979
16
Electrocardiograms of the month: Lown-Ganong-Levine syndrome and right bundle-branch block. ( 287918 )
1979
17
Lown-Ganong-Levine syndrome. ( 679452 )
1978
18
Abnormalities of atrioventricular conduction in patients with the Lown-Ganong-Levine syndrome. ( 747919 )
1978
19
Characteristics of atrioventricular conduction and the spectrum of arrhythmias in lown-ganong-levine syndrome. ( 624155 )
1978
20
Supraventricular tachycardia in Lown-Ganong-Levine syndrome: atrionodal versus intranodal reentry. ( 910716 )
1977
21
Familial atrial tachyarrhythmia with short PR interval. ( 836114 )
1977
22
Intermittent bundle-branch block in patients with accessory atrio-His or atrio-AV nodal pathways. Variants of the Lown-Ganong-Levine syndrome. ( 1259830 )
1976
23
Demonstration of dual A-V pathways in a patient with Lown-Ganong-Levine syndrome. ( 4813840 )
1974
24
Lown-Ganong-Levine syndrome. ( 5020803 )
1972
25
Taboparesis: Lown-Ganong-Levine syndrome. ( 5035914 )
1972
26
Lown-Ganong-Levine syndrome. A study using His bundle electrograms. ( 5094149 )
1971

Variations for Atrial Tachyarrhythmia with Short Pr Interval

Expression for Atrial Tachyarrhythmia with Short Pr Interval

Search GEO for disease gene expression data for Atrial Tachyarrhythmia with Short Pr Interval.

Pathways for Atrial Tachyarrhythmia with Short Pr Interval

Pathways related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.53 HLA-A HLA-B
2 11.44 HLA-A HLA-B
3 11.31 HLA-A HLA-B
4 11.09 HLA-A HLA-B
5 10.02 HLA-A HLA-B

GO Terms for Atrial Tachyarrhythmia with Short Pr Interval

Cellular components related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial membrane GO:0031966 9.46 MT-ND4 NDUFA6
2 early endosome membrane GO:0031901 9.43 HLA-A HLA-B
3 recycling endosome membrane GO:0055038 9.4 HLA-A HLA-B
4 phagocytic vesicle membrane GO:0030670 9.37 HLA-A HLA-B
5 respiratory chain GO:0070469 9.32 MT-ND4 NDUFA6
6 ER to Golgi transport vesicle membrane GO:0012507 9.26 HLA-A HLA-B
7 mitochondrial respiratory chain complex I GO:0005747 9.16 MT-ND4 NDUFA6
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-A HLA-B
9 MHC class I protein complex GO:0042612 8.62 HLA-A HLA-B

Biological processes related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.46 HLA-A HLA-B
2 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-A HLA-B
3 type I interferon signaling pathway GO:0060337 9.4 HLA-A HLA-B
4 mitochondrial respiratory chain complex I assembly GO:0032981 9.37 MT-ND4 NDUFA6
5 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.32 MT-ND4 NDUFA6
6 antigen processing and presentation GO:0019882 9.26 HLA-A HLA-B
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.16 HLA-A HLA-B
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.96 HLA-A HLA-B
9 protection from natural killer cell mediated cytotoxicity GO:0042270 8.62 HLA-A HLA-B

Molecular functions related to Atrial Tachyarrhythmia with Short Pr Interval according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.96 MT-ND4 NDUFA6
2 peptide antigen binding GO:0042605 8.62 HLA-A HLA-B

Sources for Atrial Tachyarrhythmia with Short Pr Interval

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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