MCID: ATR057
MIFTS: 54

Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Atrioventricular Block

MalaCards integrated aliases for Atrioventricular Block:

Name: Atrioventricular Block 12 30 56 6 45 15 74
Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050820
ICD9CM 36 426.10
MeSH 45 D054537
NCIt 51 C26703
SNOMED-CT 69 58547007
ICD10 34 I44.3 I44.30
UMLS 74 C0004245

Summaries for Atrioventricular Block

Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to second-degree atrioventricular block and third-degree atrioventricular block. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Cardiac conduction. The drugs Aspirin and Nicorandil have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are Decreased shRNA abundance and cardiovascular system

Wikipedia : 77 Atrioventricular block (AV block) is a type of heart block in which the conduction between the atria and... more...

Related Diseases for Atrioventricular Block

Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 296)
# Related Disease Score Top Affiliating Genes
1 second-degree atrioventricular block 34.6 HCN4 LMNA
2 third-degree atrioventricular block 34.2 HCN4 KCNE2 NPPB SCN5A
3 progressive familial heart block 32.0 SCN5A TRPM4
4 syncope 31.1 KCNH2 KCNQ1 NPPB SCN5A
5 inferior myocardial infarction 30.9 NPPB PIK3C2A
6 sick sinus syndrome 30.9 HCN4 LMNA SCN5A
7 left bundle branch hemiblock 30.6 NPPB SCN5A
8 atrial standstill 1 30.6 LMNA NPPB SCN5A
9 cardiogenic shock 30.5 NPPB PIK3C2A
10 sinoatrial node disease 30.5 HCN4 SCN5A
11 wolff-parkinson-white syndrome 30.4 KCNQ1 NKX2-5 NPPB
12 right bundle branch block 30.3 HCN4 SCN5A TRPM4
13 ventricular septal defect 30.2 GATA4 NKX2-5 NPPB TBX5
14 atrial heart septal defect 30.2 GATA4 NKX2-5 TBX5
15 mitral valve insufficiency 30.1 NPPB TBX5
16 cardiac conduction defect 30.0 KCNH2 KCNQ1 LMNA SCN5A
17 cardiac arrest 30.0 KCNH2 KCNQ1 NPPB PIK3C2A SCN5A
18 left ventricular noncompaction 29.7 HCN4 KCNQ1 LMNA NKX2-5 SCN5A
19 ventricular fibrillation, paroxysmal familial, 1 29.7 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5 SCN5A
20 arrhythmogenic right ventricular cardiomyopathy 29.6 HCN4 KCNH2 LMNA SCN5A
21 tetralogy of fallot 29.5 GATA4 KCNH2 NKX2-5 NPPB TBX5
22 long qt syndrome 29.5 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
23 atrial fibrillation 29.4 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 NPPB
24 dilated cardiomyopathy 28.6 CRYAB GATA4 KCNH2 KCNQ1 LMNA NKX2-5
25 brugada syndrome 28.5 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
26 heart disease 28.2 GATA4 HCN4 KCNE2 KCNH2 KCNQ1 LMNA
27 first-degree atrioventricular block 12.8
28 mobitz type ii atrioventricular block 12.5
29 heart block, congenital 11.8
30 progressive familial heart block, type ia 11.6
31 myocardial infarction 10.8
32 acute myocardial infarction 10.6
33 myocarditis 10.6
34 cardiac sarcoidosis 10.5
35 lymphoma 10.4
36 sarcoidosis 1 10.4
37 rere-related disorders 10.4
38 hypertrophic cardiomyopathy 10.4
39 endocarditis 10.3
40 brugada syndrome 1 10.3 KCNH2 SCN5A
41 acute myocarditis 10.3
42 ischemia 10.3
43 familial short qt syndrome 10.3 KCNH2 KCNQ1
44 arrhythmogenic right ventricular dysplasia, familial, 5 10.3 NKX2-5 SCN5A
45 arteries, anomalies of 10.3
46 progressive familial heart block, type ib 10.3
47 coronary artery anomaly 10.3
48 myopathy 10.3
49 familial sick sinus syndrome 10.3 HCN4 SCN5A
50 pulmonary valve stenosis 10.2 GATA4 SCN5A

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Aortic Valve Disease 1
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:



Diseases related to Atrioventricular Block

Symptoms & Phenotypes for Atrioventricular Block

GenomeRNAi Phenotypes related to Atrioventricular Block according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.92 KCNH2 KCNQ1 PIK3C2A TRPM4

MGI Mouse Phenotypes related to Atrioventricular Block:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 GATA4 HCN4 KCNH2 KCNQ1 LMNA NKX2-5
2 growth/size/body region MP:0005378 9.81 GATA4 KCNE2 KCNH2 KCNQ1 LMNA NKX2-5
3 muscle MP:0005369 9.61 CRYAB GATA4 HCN4 KCNH2 KCNQ1 LMNA
4 normal MP:0002873 9.17 GATA4 HCN4 KCNQ1 LMNA NKX2-5 SCN5A

Drugs & Therapeutics for Atrioventricular Block

Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
3
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
4
Ticagrelor Approved Phase 4 274693-27-5 9871419
5
Bisoprolol Approved Phase 4,Phase 3,Phase 2 66722-44-9 2405
6
Ramipril Approved Phase 4 87333-19-5 5362129
7
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
8
Amiloride Approved Phase 4 2609-46-3, 2016-88-8 16231
9
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
10
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
11
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
12
Ofloxacin Approved Phase 4 82419-36-1 4583
13
Polyestradiol phosphate Approved Phase 4 28014-46-2
14
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
15
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
16
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
17
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
18
Remifentanil Approved Phase 4 132875-61-7 60815
19
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
20
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
21
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
22
Tenecteplase Approved Phase 4 191588-94-0
23
Atenolol Approved Phase 4 29122-68-7 2249
24
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
25
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
27
Calcium Approved, Nutraceutical Phase 4,Phase 2 7440-70-2 271
28 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Vitamins Phase 4
30 Trace Elements Phase 4
31 Micronutrients Phase 4
32 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Antihypertensive Agents Phase 4,Phase 3,Phase 2
34 Folate Phase 4,Phase 2
35 Vitamin B Complex Phase 4,Phase 2
36 calcium heparin Phase 4
37 Platelet Aggregation Inhibitors Phase 4,Phase 2
38 Nutrients Phase 4
39 Vitamin B9 Phase 4,Phase 2
40 Immunologic Factors Phase 4,Phase 3,Phase 1
41 Immunosuppressive Agents Phase 4,Phase 3
42 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2
45 Anti-Infective Agents, Urinary Phase 4,Phase 2
46 Renal Agents Phase 4,Phase 2
47 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Fingolimod Hydrochloride Phase 4
49 Epithelial Sodium Channel Blockers Phase 4
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 185)
# Name Status NCT ID Phase Drugs
1 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
2 Ventricular Pacing Site Selection (V-PASS) Unknown status NCT00292383 Phase 4
3 Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
4 Effect of Nicorandil for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4 Nicorandil;normal saline
5 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
6 Comparative Study Between Cryoablation and Radiofrequency Ablation in the Treatment of Supraventricular Tachycardia Unknown status NCT01584154 Phase 4
7 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
8 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
9 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
10 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
11 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) Completed NCT00621621 Phase 4
12 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
13 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) Completed NCT01585298 Phase 4 FTY720
14 Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension Completed NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
15 Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker Indication Completed NCT00562107 Phase 4
16 Magnetically Navigated vs. Manually Guided Radiofrequency in Atrioventricular-node-reentry-tachycardia Completed NCT00875914 Phase 4
17 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Levofloxacin
18 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation Completed NCT01474213 Phase 4 dexmedetomidine group;remifentanil group
19 Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial. Completed NCT01311700 Phase 4 Injectable (i.v.) metoprolol tartrate (up to 15 mg).
20 STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction Recruiting NCT02777580 Phase 4 Tenecteplase;Clopidogrel
21 Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART) Recruiting NCT03278509 Phase 4 Metoprolol Succinate;Bisoprolol
22 Safety and Effectiveness of Drug up Titration by Nurses Specialized in Heart Failure (HF) Patients Recruiting NCT02546856 Phase 4
23 Carvedilol SR Study for Biomarkers From Blood and Urine and Safety of in Patients With Heart Failure With Preserved Ejection Fraction Not yet recruiting NCT03948685 Phase 4 Carvedilol SR;Placebo
24 Biventricular Alternative Pacing Withdrawn NCT00559143 Phase 4
25 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
26 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
27 First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) Unknown status NCT00392054 Phase 3 Conventional Antiarrhythmic Drug Therapy
28 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3 Benznidazole;Placebo
29 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
30 Safety Profile of IntRAvenous Lidocaine Use in Coelioscopic Bariatric Surgery Completed NCT02525016 Phase 3 Lidocaine
31 Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Completed NCT02386358 Phase 3 Benznidazole;Placebo
32 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3 Bisoprolol
33 Efficacy and Safety Study of Total Flavonoids of Propolis Dropping Pill to Treat Angina Pectoris Completed NCT01453582 Phase 3 Total Flavonoids of Propolis dropping pill;total Flavonoids of Propolis dropping pill
34 Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of Alzheimer's Type Completed NCT01438060 Phase 3 Aripiprazole (BMS-337039);Placebo
35 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944970 Phase 3 binodenoson;adenosine
36 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944294 Phase 3 binodenoson;adenosine
37 Aripiprazole for Schizophrenia Outpatients Completing BMS Clinical Trials Completed NCT00239356 Phase 3 Aripiprazole
38 A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT) Completed NCT01618669 Phase 3 Regadenoson
39 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
40 Bisoprolol in DMD Early Cardiomyopathy Recruiting NCT03779646 Phase 2, Phase 3 Bisoprolol Fumarate
41 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
42 Transcatheter Aortic Valve Replacement Single Center Registry in Chinese Population Not yet recruiting NCT02803294 Phase 3
43 Second Study on Cardio-neuromodulation in Humans Unknown status NCT02954666 Phase 2
44 Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler Unknown status NCT01593644 Phase 2 adenosine + dipyridamole
45 Ablation of Paroxysmal Atrial Fibrillation Using the Appropriate Contact Force in a Chinese Population Unknown status NCT02493075 Phase 1, Phase 2
46 Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania Unknown status NCT02909712 Phase 2 sulfadoxine-pyrimethamine (SP);dihydroartemisinin-piperaquine (DHA-PQP)
47 Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker Completed NCT01945606 Phase 2 Placebo (treatment 1);BAY1067197 (treatment 2)
48 Safety and Feasibility of Intracoronary Hypothermia in Acute Myocardial Infarction Completed NCT02753478 Phase 1, Phase 2
49 Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration Completed NCT01570790 Phase 1, Phase 2 Combretastatin A-4 phosphate;Combretastatin A-4 Phosphate;Combretastatin A-4 Phosphate
50 SB-705498 Dental Pain Study After Tooth Extraction Completed NCT00281684 Phase 2 SB705498 400 mg;SB705498 1000 mg;Placebo;Co-Codamol

Search NIH Clinical Center for Atrioventricular Block

Cochrane evidence based reviews: atrioventricular block

Genetic Tests for Atrioventricular Block

Genetic tests related to Atrioventricular Block:

# Genetic test Affiliating Genes
1 Atrioventricular Block 30

Anatomical Context for Atrioventricular Block

MalaCards organs/tissues related to Atrioventricular Block:

42
Heart, Testes, Atrioventricular Node, Lung, B Cells, Kidney, Brain

Publications for Atrioventricular Block

Articles related to Atrioventricular Block:

(show top 50) (show all 2199)
# Title Authors Year
1
Atrioventricular block can be used as a risk predictor of clinical atrial fibrillation. ( 30801746 )
2019
2
Reversible mechanical atrioventricular block during cryoablation for paroxysmal atrial fibrillation with a 28 mm balloon. ( 30693198 )
2019
3
First-degree atrioventricular block on basal electrocardiogram predicts future arrhythmic events in patients with Brugada syndrome: a long-term follow-up study from the Veneto region of Northeastern Italy. ( 29986018 )
2019
4
Leadless pacemaker used as long-term temporary therapy in Lyme carditis with high-grade atrioventricular block. ( 30059962 )
2019
5
Disruption of RHOA-ROCK Signaling Results in Atrioventricular Block and Disturbed Development of the Putative Atrioventricular Node. ( 30412368 )
2019
6
High-degree atrioventricular block revealing hypertrophic cardiomyopathy related to a mutation in MYBPC3 gene. ( 30528150 )
2019
7
The Lotus Valve Is Safe and Effective, But Will Atrioventricular Block Improve With the Next-Generation System? ( 30621977 )
2019
8
Risk factors for atrioventricular block after transcatheter aortic valve implantation: a single-centre analysis including assessment of aortic calcifications and follow-up. ( 30629159 )
2019
9
Aripiprazole overdose and transient 2:1 second degree atrioventricular block: only a coincidence? ( 30659549 )
2019
10
Atrioventricular Block During Catheter Ablation for Ventricular Arrhythmias. ( 30678774 )
2019
11
Paradoxical nonreentrant tachycardia induced by iatrogenic atrioventricular block. ( 30735477 )
2019
12
Case report: Atrioventricular block after transcatheter atrial septal closure using the Figulla® Flex II ASD occluder. ( 30773790 )
2019
13
Rescue Percutaneous Coronary Intervention for a Lethal "Jailed" Septal Perforator Branch to Resolve Delayed Complete Atrioventricular Block. ( 30799381 )
2019
14
A rare case of Staphylococcus lugdunensis septicemia associated with myocarditis and atrioventricular block. ( 30800154 )
2019
15
A 2:1 atrioventricular block presenting paradoxical ventriculophasic response. ( 30888696 )
2019
16
His-bundle pacing in a patient with dextrocardia, severe systolic dysfunction, and complete atrioventricular block. ( 30891412 )
2019
17
Appropriate use of genetics in a young patient with atrioventricular block and family history of sudden cardiac death. ( 30891417 )
2019
18
Potential usage of cardioneuroablation in vagally mediated functional atrioventricular block. ( 30906551 )
2019
19
Atrioventricular block after congenital heart surgery: Analysis from the Pediatric Cardiac Critical Care Consortium. ( 30917883 )
2019
20
Cardiac Magnetic Resonance Identified the Fibrotic Lesion Associated with Syncope Attack Due to Complete Atrioventricular Block in a Patient with Hypertrophic Cardiomyopathy and Aortic Stenosis. ( 30918200 )
2019
21
Frequency and characteristics of exercise-induced second-degree atrioventricular block in patients undergoing stress testing. ( 30925274 )
2019
22
A Unique Case of Complete Atrioventricular Block Rapidly Progressing to Diastolic and Systolic Dysfunction in Cardiac Sarcoidosis. ( 30956665 )
2019
23
Complete atrioventricular block during exercise: New insights from an old test. ( 30968667 )
2019
24
Atrioventricular block at the distal His bundle: Electrophysiological insights from left bundle branch pacing. ( 30997342 )
2019
25
Causes of fetal third-degree atrioventricular block and use of hydroxychloroquine in pregnant women with Ro/La antibodies. ( 30997589 )
2019
26
Intraprocedural high-degree atrioventricular block or complete heart block in transcatheter aortic valve replacement recipients with no prior intraventricular conduction disturbances. ( 31037836 )
2019
27
Permanent left bundle branch area pacing for atrioventricular block: feasibility, safety and acute effect. ( 31048065 )
2019
28
Predicting postpartum cardiac events in pregnant women with complete atrioventricular block. ( 31060956 )
2019
29
A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies. ( 31061413 )
2019
30
Multiscale simulation of the effects of atrioventricular block and valve diseases on heart performance. ( 31083764 )
2019
31
Post-pacemaker implant QRS duration and heart failure admission in patients with sick sinus syndrome and complete atrioventricular block. ( 31111655 )
2019
32
Maternal steroid therapy for fetuses with immune-mediated complete atrioventricular block: a systematic review and meta-analysis. ( 29251180 )
2019
33
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2019
34
Dextrocardia with complete AV block and the implantation of a temporary pacemaker before cesarean section: A case report. ( 31027067 )
2019
35
Exposure to glucocorticoids prior to transcatheter aortic valve replacement is associated with reduced incidence of high-degree AV block and pacemaker. ( 30037717 )
2019
36
Treating Lyme carditis high-degree AV block using a temporary-permanent pacemaker. ( 30265432 )
2019
37
Fortuitous Identification of Fluctuating AV Block: A Case Report. ( 31072656 )
2019
38
Atrioventricular block after acute myocardial infarction and its association with other clinical parameters in Pakistani patients: an institutional perspective. ( 29784020 )
2018
39
High-grade atrioventricular block in patients with acute myocardial infarction. Insights from a contemporary multi-center survey. ( 29550105 )
2018
40
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring. ( 29877257 )
2018
41
Dynamic Electrocardiography is Useful in the Diagnosis of Persistent Atrial Fibrillation Accompanied with Second-Degree Atrioventricular Block. ( 30271091 )
2018
42
Early childhood onset of high-grade atrioventricular block in Hunter syndrome. ( 29506582 )
2018
43
Unexpected delayed complete atrioventricular block after Cardioband implantation. ( 29508515 )
2018
44
Maternal steroid therapy for fetuses with second-degree immune-mediated congenital atrioventricular block: a systematic review and meta-analysis. ( 29512819 )
2018
45
Intramyocardial block in patients with atrioventricular block. ( 29514866 )
2018
46
Paliperidone-Associated Atrioventricular Block. ( 29528883 )
2018
47
Lyme Carditis and High-Degree Atrioventricular Block. ( 29598856 )
2018
48
Full Atrioventricular Block Secondary to Acute Poisoning Mercury: A Case Report. ( 29614795 )
2018
49
Case Report: III° atrioventricular block due to fulminant myocarditis managed with non-invasive transcutaneous pacing. ( 29636901 )
2018
50
Slow pathway modification for treatment of pseudo-pacemaker syndrome due to first-degree atrioventricular block with dual atrioventricular nodal physiology. ( 29707483 )
2018

Variations for Atrioventricular Block

ClinVar genetic disease variations for Atrioventricular Block:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh37 Chromosome 3, 38595800: 38595800
2 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh38 Chromosome 3, 38554309: 38554309
3 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh37 Chromosome 3, 38651267: 38651267
4 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh38 Chromosome 3, 38609776: 38609776

Expression for Atrioventricular Block

Search GEO for disease gene expression data for Atrioventricular Block.

Pathways for Atrioventricular Block

Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 KCNE1 KCNQ1 SCN5A TRPM4
2
Show member pathways
12.29 GATA4 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5
3
Show member pathways
12.22 GATA4 NKX2-5 NPPB TBX5
4 12.11 KCNE1 KCNE2 KCNH2 KCNQ1
5
Show member pathways
11.98 GATA4 NKX2-5 TBX5
6 11.91 KCNH2 KCNQ1 SCN5A
7
Show member pathways
11.86 HCN4 KCNH2 KCNQ1
8 11.79 GATA4 NKX2-5 TBX5
9
Show member pathways
11.43 KCNE1 KCNE2 KCNQ1 SCN5A
10 11.24 GATA4 NKX2-5 TBX5
11 11.18 GATA4 NKX2-5 SCN5A TBX5
12 10.92 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 LMNA
13 10.89 GATA4 NKX2-5 NPPB
14 10.78 HCN4 KCNE1 KCNQ1
15 10.21 GATA4 NKX2-5

GO Terms for Atrioventricular Block

Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 CRYAB KCNE1 KCNE2 KCNH2 SCN5A
2 Z disc GO:0030018 9.33 CRYAB KCNE1 SCN5A
3 voltage-gated potassium channel complex GO:0008076 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.91 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
2 regulation of ion transmembrane transport GO:0034765 9.91 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
3 potassium ion transmembrane transport GO:0071805 9.88 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
4 regulation of membrane potential GO:0042391 9.86 HCN4 KCNH2 TRPM4
5 cellular response to drug GO:0035690 9.82 KCNE2 KCNH2 KCNQ1
6 cellular response to cAMP GO:0071320 9.8 HCN4 KCNE1 KCNQ1
7 cardiac muscle contraction GO:0060048 9.8 KCNH2 KCNQ1 NKX2-5 SCN5A
8 cardiac muscle cell differentiation GO:0055007 9.77 GATA4 NKX2-5 TBX5
9 regulation of potassium ion transmembrane transport GO:1901379 9.76 KCNE1 KCNE2 KCNH2
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.75 KCNE1 KCNE2 SCN5A
11 positive regulation of potassium ion transmembrane transport GO:1901381 9.74 KCNE1 KCNH2 KCNQ1
12 atrial septum morphogenesis GO:0060413 9.73 GATA4 NKX2-5 TBX5
13 regulation of membrane repolarization GO:0060306 9.72 KCNE2 KCNH2 KCNQ1
14 potassium ion export across plasma membrane GO:0097623 9.71 KCNE1 KCNE2 KCNH2 KCNQ1
15 regulation of heart rate GO:0002027 9.7 HCN4 SCN5A
16 ventricular septum development GO:0003281 9.7 GATA4 TBX5
17 positive regulation of heart rate GO:0010460 9.7 KCNQ1 TRPM4
18 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.7 KCNE1 KCNH2 KCNQ1
19 regulation of cardiac muscle contraction GO:0055117 9.69 HCN4 NKX2-5
20 cardiovascular system development GO:0072358 9.69 KCNQ1 NKX2-5
21 membrane depolarization during action potential GO:0086010 9.68 KCNH2 SCN5A
22 positive regulation of sodium ion transport GO:0010765 9.68 NKX2-5 SCN5A
23 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.68 KCNE1 KCNE2
24 sodium ion import across plasma membrane GO:0098719 9.68 HCN4 TRPM4
25 endocardial cushion development GO:0003197 9.67 GATA4 TBX5
26 regulation of cardiac muscle cell contraction GO:0086004 9.67 GATA4 SCN5A
27 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.67 HCN4 SCN5A
28 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNE1 KCNE2 KCNH2 KCNQ1
29 cardiac ventricle morphogenesis GO:0003208 9.66 GATA4 NKX2-5
30 ventricular cardiac muscle cell development GO:0055015 9.66 LMNA NKX2-5
31 atrial cardiac muscle cell action potential GO:0086014 9.65 KCNQ1 SCN5A
32 regulation of delayed rectifier potassium channel activity GO:1902259 9.65 KCNE1 KCNE2
33 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.64 KCNQ1 SCN5A
34 SA node cell action potential GO:0086015 9.63 HCN4 SCN5A
35 positive regulation of cardioblast differentiation GO:0051891 9.63 GATA4 NKX2-5 TBX5
36 membrane depolarization during AV node cell action potential GO:0086045 9.62 SCN5A TRPM4
37 membrane depolarization during SA node cell action potential GO:0086046 9.62 HCN4 SCN5A
38 membrane repolarization GO:0086009 9.62 KCNE1 KCNE2 KCNH2 KCNQ1
39 bundle of His development GO:0003166 9.61 NKX2-5 TBX5
40 membrane depolarization during bundle of His cell action potential GO:0086048 9.61 SCN5A TRPM4
41 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.6 SCN5A TRPM4
42 membrane repolarization during action potential GO:0086011 9.56 KCNE1 KCNE2 KCNH2 KCNQ1
43 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.55 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
44 ventricular cardiac muscle cell action potential GO:0086005 9.35 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
45 regulation of heart rate by cardiac conduction GO:0086091 9.17 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
46 ion transport GO:0006811 10.08 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
47 transmembrane transport GO:0055085 10.05 HCN4 KCNH2 KCNQ1 SCN5A TRPM4

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.76 HCN4 KCNH2 SCN5A TRPM4
2 voltage-gated ion channel activity GO:0005244 9.72 HCN4 KCNE2 KCNH2 KCNQ1 SCN5A
3 calmodulin binding GO:0005516 9.71 KCNQ1 SCN5A TRPM4
4 ion channel binding GO:0044325 9.71 KCNE1 KCNE2 KCNQ1 SCN5A
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.7 GATA4 NKX2-5 TBX5
6 scaffold protein binding GO:0097110 9.65 KCNH2 KCNQ1 SCN5A
7 delayed rectifier potassium channel activity GO:0005251 9.56 KCNE1 KCNE2 KCNH2 KCNQ1
8 potassium channel activity GO:0005267 9.55 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
9 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.54 KCNE1 KCNH2 KCNQ1
10 inward rectifier potassium channel activity GO:0005242 9.51 KCNE2 KCNH2
11 voltage-gated sodium channel activity GO:0005248 9.49 HCN4 SCN5A
12 sodium channel activity GO:0005272 9.43 HCN4 SCN5A
13 voltage-gated potassium channel activity GO:0005249 9.35 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
14 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Sources for Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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