MCID: ATR057
MIFTS: 52

Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Atrioventricular Block

MalaCards integrated aliases for Atrioventricular Block:

Name: Atrioventricular Block 12 29 55 6 44 15 73
Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050820
ICD10 33 I44.3 I44.30
ICD9CM 35 426.10
MeSH 44 D054537
NCIt 50 C26703
UMLS 73 C0004245

Summaries for Atrioventricular Block

Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to third-degree atrioventricular block and inferior myocardial infarction. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and Human Embryonic Stem Cell Pluripotency. The drugs Enfuvirtide and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotypes are Decreased shRNA abundance and cardiovascular system

Wikipedia : 76 Atrioventricular block (AV block) is a type of heart block in which the conduction between the atria and... more...

Related Diseases for Atrioventricular Block

Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 third-degree atrioventricular block 33.9 HCN4 KCNE2 NPPB
2 inferior myocardial infarction 30.8 NPPB PIK3C2A
3 sick sinus syndrome 30.7 HCN4 LMNA SCN5A
4 syncope 30.6 KCNH2 KCNQ1 NPPB SCN5A
5 cardiogenic shock 30.4 NPPB PIK3C2A
6 atrial standstill 1 30.0 LMNA NPPB SCN5A
7 right bundle branch block 29.8 HCN4 SCN5A TRPM4
8 cardiac conduction defect 29.7 KCNH2 KCNQ1 LMNA SCN5A
9 atrial heart septal defect 29.6 GATA4 NKX2-5 TBX5
10 cardiac arrest 29.5 KCNQ1 PIK3C2A SCN5A
11 ventricular septal defect 29.5 GATA4 NKX2-5 NPPB TBX5
12 left ventricular noncompaction 29.1 HCN4 KCNQ1 LMNA NKX2-5 SCN5A
13 ventricular fibrillation, paroxysmal familial, 1 28.5 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5 SCN5A
14 tetralogy of fallot 28.5 GATA4 KCNH2 NKX2-5 NPPB TBX5
15 long qt syndrome 27.9 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
16 atrial fibrillation 27.6 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 NPPB
17 dilated cardiomyopathy 26.2 CRYAB GATA4 KCNH2 KCNQ1 LMNA NKX2-5
18 heart disease 25.6 GATA4 KCNE2 KCNH2 KCNQ1 LMNA NKX2-5
19 first-degree atrioventricular block 12.6
20 second-degree atrioventricular block 12.6
21 mobitz type ii atrioventricular block 12.3
22 heart block, congenital 11.6
23 progressive familial heart block, type ia 11.3
24 brugada syndrome 1 10.6 KCNH2 SCN5A
25 familial short qt syndrome 10.6 KCNH2 KCNQ1
26 familial sick sinus syndrome 10.5 HCN4 SCN5A
27 cardiomyopathy, dilated, 1e 10.4 LMNA NKX2-5 SCN5A
28 long qt syndrome 13 10.4 KCNH2 KCNQ1 SCN5A
29 myocardial infarction 10.4
30 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 10.4 KCNH2 KCNQ1 SCN5A
31 arrhythmogenic right ventricular dysplasia, familial, 5 10.4 NKX2-5 SCN5A
32 myocarditis 10.3
33 long qt syndrome 9 10.3 HCN4 SCN5A
34 cardiac sarcoidosis 10.3
35 timothy syndrome 10.3 KCNE1 KCNH2 KCNQ1
36 tricuspid valve disease 10.2 NKX2-5 NPPB
37 sinoatrial node disease 10.2 HCN4 SCN5A
38 arrhythmogenic right ventricular cardiomyopathy 10.2 KCNH2 LMNA SCN5A
39 ebstein anomaly 10.2 GATA4 NKX2-5 NPPB
40 acute myocarditis 10.2
41 toxic myocarditis 10.2 NPPB PIK3C2A
42 progressive familial heart block 10.2 SCN5A TRPM4
43 type i 10.1
44 pulmonary valve disease 10.1 GATA4 TBX5
45 progressive familial heart block, type ib 10.1
46 acute myocardial infarction 10.1
47 endocarditis 10.1
48 myopathy 10.1
49 familial progressive cardiac conduction defect 10.1 NKX2-5 SCN5A TRPM4
50 kearns-sayre syndrome 10.1

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Aortic Valve Disease 1
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:



Diseases related to Atrioventricular Block

Symptoms & Phenotypes for Atrioventricular Block

GenomeRNAi Phenotypes related to Atrioventricular Block according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.92 KCNH2 KCNQ1 PIK3C2A TRPM4

MGI Mouse Phenotypes related to Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 NKX2-5 PIK3C2A SCN5A TBX5 TRPM4 GATA4
2 growth/size/body region MP:0005378 9.81 GATA4 KCNE2 KCNH2 KCNQ1 LMNA NKX2-5
3 muscle MP:0005369 9.61 CRYAB GATA4 HCN4 KCNH2 KCNQ1 LMNA
4 normal MP:0002873 9.17 GATA4 HCN4 KCNQ1 LMNA NKX2-5 SCN5A

Drugs & Therapeutics for Atrioventricular Block

Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enfuvirtide Approved, Investigational Phase 4 159519-65-0 16130199
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
4
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
5
Ticagrelor Approved Phase 4 274693-27-5 9871419
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
8
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
9
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
10
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
11
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
12
Ofloxacin Approved Phase 4 82419-36-1 4583
13
Polyestradiol phosphate Approved Phase 4 28014-46-2
14
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
17
Bisoprolol Approved Phase 4,Phase 3 66722-44-9 2405
18
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
19
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
20
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
21
Ramipril Approved Phase 4 87333-19-5 5362129
22
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
23
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
24
Tenecteplase Approved Phase 4 191588-94-0
25
Atenolol Approved Phase 4 29122-68-7 2249
26
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
28 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Antihypertensive Agents Phase 4,Phase 3
30 calcium heparin Phase 4
31 Micronutrients Phase 4
32 Platelet Aggregation Inhibitors Phase 4,Phase 2
33 Trace Elements Phase 4
34 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Vitamin B Complex Phase 4,Phase 2
36 Vitamins Phase 4
37 Immunosuppressive Agents Phase 4,Phase 3
38 Anti-Infective Agents Phase 4,Phase 3,Phase 2
39 Renal Agents Phase 4,Phase 2
40 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Fingolimod Hydrochloride Phase 4
44 Anti-Bacterial Agents Phase 4
45 Contraceptive Agents Phase 4
46 Contraceptives, Oral Phase 4
47 Contraceptives, Oral, Combined Phase 4
48 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
49 Cytochrome P-450 Enzyme Inhibitors Phase 4
50 Estradiol 17 beta-cypionate Phase 4

Interventional clinical trials:

(show top 50) (show all 161)
# Name Status NCT ID Phase Drugs
1 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
2 Ventricular Pacing Site Selection (V-PASS) Unknown status NCT00292383 Phase 4
3 Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
4 Effect of Nicorandil for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4 Nicorandil;normal saline
5 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
6 Comparative Study Between Cryoablation and Radiofrequency Ablation in the Treatment of Supraventricular Tachycardia Unknown status NCT01584154 Phase 4
7 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
8 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
9 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
10 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
11 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) Completed NCT00621621 Phase 4
12 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
13 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) Completed NCT01585298 Phase 4 FTY720
14 Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker Indication Completed NCT00562107 Phase 4
15 Magnetically Navigated vs. Manually Guided Radiofrequency in Atrioventricular-node-reentry-tachycardia Completed NCT00875914 Phase 4
16 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Levofloxacin
17 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation Completed NCT01474213 Phase 4 dexmedetomidine group;remifentanil group
18 Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial. Completed NCT01311700 Phase 4 Injectable (i.v.) metoprolol tartrate (up to 15 mg).
19 Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension Recruiting NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
20 STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction Recruiting NCT02777580 Phase 4 Tenecteplase;Clopidogrel
21 Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART) Recruiting NCT03278509 Phase 4 Metoprolol Succinate;Bisoprolol
22 Safety and Effectiveness of Drug up Titration by Nurses Specialized in Heart Failure (HF) Patients Recruiting NCT02546856 Phase 4
23 Biventricular Alternative Pacing Withdrawn NCT00559143 Phase 4
24 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
25 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
26 First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) Unknown status NCT00392054 Phase 3 Conventional Antiarrhythmic Drug Therapy
27 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3 Benznidazole;Placebo
28 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
29 Safety Profile of IntRAvenous Lidocaine Use in Coelioscopic Bariatric Surgery Completed NCT02525016 Phase 3 Lidocaine
30 Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Completed NCT02386358 Phase 3 Benznidazole;Placebo
31 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3 Bisoprolol
32 Efficacy and Safety Study of Total Flavonoids of Propolis Dropping Pill to Treat Angina Pectoris Completed NCT01453582 Phase 3 Total Flavonoids of Propolis dropping pill;total Flavonoids of Propolis dropping pill
33 Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of Alzheimer's Type Completed NCT01438060 Phase 3 Aripiprazole (BMS-337039);Placebo
34 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944970 Phase 3 binodenoson;adenosine
35 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944294 Phase 3 binodenoson;adenosine
36 Aripiprazole for Schizophrenia Outpatients Completing BMS Clinical Trials Completed NCT00239356 Phase 3 Aripiprazole
37 A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT) Completed NCT01618669 Phase 3 Regadenoson
38 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
39 Impact of Right Ventricular Pacing Determined by Electrocardiography Recruiting NCT01922518 Phase 3
40 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
41 Transcatheter Aortic Valve Replacement Single Center Registry in Chinese Population Not yet recruiting NCT02803294 Phase 3
42 Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler Unknown status NCT01593644 Phase 2 adenosine + dipyridamole
43 Ablation of Paroxysmal Atrial Fibrillation Using the Appropriate Contact Force in a Chinese Population Unknown status NCT02493075 Phase 1, Phase 2
44 Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania Unknown status NCT02909712 Phase 2 sulfadoxine-pyrimethamine (SP);dihydroartemisinin-piperaquine (DHA-PQP)
45 Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker Completed NCT01945606 Phase 2 Placebo (treatment 1);BAY1067197 (treatment 2)
46 Safety and Feasibility of Intracoronary Hypothermia in Acute Myocardial Infarction Completed NCT02753478 Phase 1, Phase 2
47 Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration Completed NCT01570790 Phase 1, Phase 2 Combretastatin A-4 phosphate;Combretastatin A-4 Phosphate;Combretastatin A-4 Phosphate
48 SB-705498 Dental Pain Study After Tooth Extraction Completed NCT00281684 Phase 2 SB705498 400 mg;SB705498 1000 mg;Placebo;Co-Codamol
49 Multiple Dose Study in Heart Failure of BAY 1067197 Completed NCT02040233 Phase 2 BAY1067197 (10 mg);BAY1067197;Placebo (10 mg);Placebo
50 4 Week Switch Study in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease Completed NCT01587924 Phase 2 GSK1278863;rhEPO

Search NIH Clinical Center for Atrioventricular Block

Cochrane evidence based reviews: atrioventricular block

Genetic Tests for Atrioventricular Block

Genetic tests related to Atrioventricular Block:

# Genetic test Affiliating Genes
1 Atrioventricular Block 29

Anatomical Context for Atrioventricular Block

MalaCards organs/tissues related to Atrioventricular Block:

41
Heart, Testes, Kidney, Brain, Lung, Atrioventricular Node, B Cells

Publications for Atrioventricular Block

Articles related to Atrioventricular Block:

(show top 50) (show all 437)
# Title Authors Year
1
Gerbezius' Pulsus Mira Inconstantia and the First Descriptions of the Atrioventricular Block. ( 29784478 )
2018
2
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2018
3
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )
2018
4
Chronic Apical and Nonapical Right Ventricular Pacing in Patients with High-Grade Atrioventricular Block: Results of the Right Pace Study. ( 29951525 )
2018
5
High Grade Atrioventricular Block in Von Recklinghausen Disease: A Rare Phenomenon. ( 29904455 )
2018
6
Major determinant of the occurrence of pacing-induced cardiomyopathy in complete atrioventricular block: a multicentre, retrospective analysis over a 15-year period in South Korea. ( 29439074 )
2018
7
Marked First-Degree Atrioventricular Block and Pseudo-Pacemaker Syndrome in a Pediatric Patient. ( 29435607 )
2018
8
Second-degree Atrioventricular Block: Conceptions and Misconceptions. ( 29977560 )
2018
9
Atrioventricular block after acute myocardial infarction and its association with other clinical parameters in Pakistani patients: an institutional perspective. ( 29784020 )
2018
10
An extremely rare clinical entity: congenitally corrected transposition with situs A+nversus and single coronary artery presented with complete atrioventricular block in a young man. ( 29428001 )
2018
11
Importance of Early Diagnosis of Cardiac Sarcoidosis in Patients with Complete Atrioventricular Block. ( 29794391 )
2018
12
Complete Atrioventricular Block in an Elderly Patient Treated with Low-Dose Lacosamide. ( 29948594 )
2018
13
Lyme carditis and atrioventricular block. ( 29789287 )
2018
14
An unusual case of complete atrioventricular block causing Takotsubo syndrome. ( 29325979 )
2018
15
Recovery of High Degree Atrioventricular Block in a Patient with Cardiac Sarcoidosis by Corticosteroid Therapy. ( 29399570 )
2018
16
Cardiac resynchronization therapy improves left ventricular remodeling and function compared with right ventricular pacing in patients with atrioventricular block. ( 29968221 )
2018
17
Wide QRS complex tachycardia followed by 2:1 atrioventricular block: What is the mechanism? ( 29328513 )
2018
18
Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome. ( 29350247 )
2018
19
Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs. ( 29753687 )
2018
20
Cardiac pacing for complete atrioventricular block complicating heart lymphoma: A challenging issue. ( 29933920 )
2018
21
Progression of intrahisian atrioventricular block: Will this presage a renaissance of His-bundle studies? ( 29758403 )
2018
22
Impact of high-grade Atrioventricular block and cumulative frequent pacing on atrial arrhythmias. ( 29931776 )
2018
23
Adenosine hypersensitivity and atrioventricular block. ( 29845316 )
2018
24
Prediction of Delayed Atrioventricular Block and Pacemaker Implantation After Transcatheter Aortic Valve Replacement With CoreValve. ( 29223288 )
2018
25
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring. ( 29877257 )
2018
26
A Case of Atrioventricular Block Potentially Associated with Right Coronary Artery Lesion and Ticagrelor Therapy Mediated by the Increasing Adenosine Plasma Concentration. ( 29850368 )
2018
27
Slow pathway modification for treatment of pseudo-pacemaker syndrome due to first-degree atrioventricular block with dual atrioventricular nodal physiology. ( 29707483 )
2018
28
Risperidone-Associated Atrioventricular Block. ( 29927774 )
2018
29
A Case of Congenital Complete Atrioventricular Block Treated with Transdermal Tulobuterol. ( 29955022 )
2018
30
Echocardiographic assessment of ventricular contraction and synchrony in children with isolated complete atrioventricular block and epicardial pacing: Implications of interventricular mechanical delay. ( 29808935 )
2018
31
Atrioventricular block due to papillary fibroelastoma. ( 28942946 )
2017
32
Heparan sulfate storage in the cardiac conduction system triggers atrioventricular block. ( 28089344 )
2017
33
Syncope, Junctional Premature Complexes, and Pseudo-Type II Atrioventricular Block. ( 29395000 )
2017
34
Hypopituitarism and hypothyroidism following atrioventricular block during nivolumab treatment. ( 28295551 )
2017
35
Symptomatic first-degree atrioventricular block in a young woman after taking a fat burner supplement. ( 29162998 )
2017
36
Paroxysmal atrioventricular block: Electrophysiological mechanism of phase 4 conduction block in the His-Purkinje system: A comparison with phase 3 block. ( 28846146 )
2017
37
Frequency of Recovery from Complete Atrioventricular Block After Cardiac Surgery. ( 28864321 )
2017
38
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. ( 27886613 )
2017
39
Marked Symptomatic Sinus Bradycardia With New Onset First-Degree Atrioventricular Block After Concomitant Methadone and Trazodone Use. ( 28953513 )
2017
40
Successful prenatal management of ventricular tachycardia and second-degree atrioventricular block in fetal long QT syndrome. ( 28491768 )
2017
41
Complex phenotype linked to a mutation in exon 11 of the lamin A/C gene: Hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes. ( 28874324 )
2017
42
Atrioventricular block after reperfusion: A reflection on early beta-blocker therapy for acute myocardial infarction. ( 29256884 )
2017
43
Mobitz Type II Atrioventricular Block following Tramadol and Fentanyl in a Patient with Acute Coronary Syndrome and Systolic Heart Failure. ( 29184615 )
2017
44
Swallow presyncope in an athletic patient caused by third-degree atrioventricular block. ( 29202647 )
2017
45
The use of non-invasive fetal electrocardiography in diagnosing second-degree fetal atrioventricular block. ( 28794892 )
2017
46
Acute Idiopathic Gastric Distension Causing Atrioventricular Block and Cardiogenic Shock. ( 28602457 )
2017
47
Perservative paroxysmal atrioventricular block : Cardiac syncope misdiagnosed as anxiety for more than 20A years. ( 28840364 )
2017
48
Syncope and paroxysmal atrioventricular block. ( 29255501 )
2017
49
Genetic Mechanisms Contribute to the Development of Heart Failure in Patients with Atrioventricular Block and Right Ventricular Apical Pacing. ( 28878402 )
2017
50
Maternal steroid therapy for fetuses with immune-mediated complete atrioventricular block: a systematic review and meta-analysis. ( 29251180 )
2017

Variations for Atrioventricular Block

ClinVar genetic disease variations for Atrioventricular Block:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh37 Chromosome 3, 38595800: 38595800
2 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh38 Chromosome 3, 38554309: 38554309

Expression for Atrioventricular Block

Search GEO for disease gene expression data for Atrioventricular Block.

Pathways for Atrioventricular Block

Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 GATA4 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5
2
Show member pathways
12.22 GATA4 NKX2-5 NPPB TBX5
3 12.11 KCNE1 KCNE2 KCNH2 KCNQ1
4
Show member pathways
11.97 GATA4 NKX2-5 TBX5
5 11.91 KCNH2 KCNQ1 SCN5A
6
Show member pathways
11.86 HCN4 KCNH2 KCNQ1
7 11.79 GATA4 NKX2-5 TBX5
8
Show member pathways
11.43 KCNE1 KCNE2 KCNQ1 SCN5A
9 11.24 GATA4 NKX2-5 TBX5
10 11.18 GATA4 NKX2-5 SCN5A TBX5
11 10.92 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 LMNA
12 10.89 GATA4 NKX2-5 NPPB
13 10.78 HCN4 KCNE1 KCNQ1
14 10.21 GATA4 NKX2-5

GO Terms for Atrioventricular Block

Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 CRYAB KCNE1 KCNE2 KCNH2 SCN5A
2 Z disc GO:0030018 9.33 CRYAB KCNE1 SCN5A
3 voltage-gated potassium channel complex GO:0008076 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.95 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
2 potassium ion transport GO:0006813 9.93 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
3 potassium ion transmembrane transport GO:0071805 9.91 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
4 regulation of membrane potential GO:0042391 9.87 HCN4 KCNH2 TRPM4
5 cellular response to drug GO:0035690 9.83 KCNE2 KCNH2 KCNQ1
6 cardiac muscle contraction GO:0060048 9.83 KCNH2 KCNQ1 NKX2-5 SCN5A
7 cellular response to cAMP GO:0071320 9.8 HCN4 KCNE1 KCNQ1
8 cardiac muscle cell differentiation GO:0055007 9.77 GATA4 NKX2-5 TBX5
9 regulation of potassium ion transmembrane transport GO:1901379 9.77 KCNE1 KCNE2 KCNH2
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.76 KCNE1 KCNE2 SCN5A
11 regulation of membrane repolarization GO:0060306 9.76 KCNE1 KCNE2 KCNH2 KCNQ1
12 positive regulation of potassium ion transmembrane transport GO:1901381 9.75 KCNE1 KCNH2 KCNQ1
13 atrial septum morphogenesis GO:0060413 9.74 GATA4 NKX2-5 TBX5
14 membrane repolarization GO:0086009 9.73 KCNE1 KCNE2 KCNH2 KCNQ1
15 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.72 KCNE1 KCNH2 KCNQ1
16 potassium ion export GO:0071435 9.71 KCNE1 KCNE2 KCNH2 KCNQ1
17 ventricular septum development GO:0003281 9.7 GATA4 TBX5
18 membrane depolarization during action potential GO:0086010 9.7 KCNH2 SCN5A
19 regulation of cardiac muscle contraction GO:0055117 9.7 HCN4 NKX2-5
20 positive regulation of heart rate GO:0010460 9.7 KCNQ1 TRPM4
21 positive regulation of sodium ion transport GO:0010765 9.69 NKX2-5 SCN5A
22 sodium ion import across plasma membrane GO:0098719 9.69 HCN4 TRPM4
23 cardiovascular system development GO:0072358 9.68 KCNQ1 NKX2-5
24 endocardial cushion development GO:0003197 9.68 GATA4 TBX5
25 regulation of cardiac muscle cell contraction GO:0086004 9.68 GATA4 SCN5A
26 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.68 HCN4 SCN5A
27 ventricular cardiac muscle cell development GO:0055015 9.67 LMNA NKX2-5
28 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.67 KCNE1 KCNE2
29 positive regulation of cardioblast differentiation GO:0051891 9.67 GATA4 NKX2-5 TBX5
30 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNE1 KCNE2 KCNH2 KCNQ1
31 cardiac ventricle morphogenesis GO:0003208 9.66 GATA4 NKX2-5
32 atrial cardiac muscle cell action potential GO:0086014 9.66 KCNQ1 SCN5A
33 regulation of delayed rectifier potassium channel activity GO:1902259 9.65 KCNE1 KCNE2
34 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.65 KCNQ1 SCN5A
35 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
36 SA node cell action potential GO:0086015 9.64 HCN4 SCN5A
37 membrane depolarization during AV node cell action potential GO:0086045 9.64 SCN5A TRPM4
38 membrane depolarization during SA node cell action potential GO:0086046 9.63 HCN4 SCN5A
39 potassium ion export across plasma membrane GO:0097623 9.62 KCNH2 KCNQ1
40 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.62 SCN5A TRPM4
41 membrane repolarization during action potential GO:0086011 9.62 KCNE1 KCNE2 KCNH2 KCNQ1
42 bundle of His development GO:0003166 9.61 NKX2-5 TBX5
43 membrane depolarization during bundle of His cell action potential GO:0086048 9.61 SCN5A TRPM4
44 ventricular cardiac muscle cell action potential GO:0086005 9.55 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
45 cardiac conduction GO:0061337 9.43 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A TRPM4
46 regulation of heart rate by cardiac conduction GO:0086091 9.17 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
47 ion transport GO:0006811 10.1 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
48 transmembrane transport GO:0055085 10.06 HCN4 KCNH2 KCNQ1 SCN5A TRPM4

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.73 HCN4 KCNH2 SCN5A TRPM4
2 voltage-gated ion channel activity GO:0005244 9.72 HCN4 KCNE2 KCNH2 KCNQ1 SCN5A
3 calmodulin binding GO:0005516 9.71 KCNQ1 SCN5A TRPM4
4 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.7 GATA4 NKX2-5 TBX5
5 ion channel binding GO:0044325 9.65 KCNE2 KCNQ1 SCN5A
6 scaffold protein binding GO:0097110 9.63 KCNH2 KCNQ1 SCN5A
7 sodium channel activity GO:0005272 9.58 HCN4 SCN5A TRPM4
8 delayed rectifier potassium channel activity GO:0005251 9.56 KCNE1 KCNE2 KCNH2 KCNQ1
9 potassium channel activity GO:0005267 9.55 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
10 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.54 KCNE1 KCNH2 KCNQ1
11 voltage-gated sodium channel activity GO:0005248 9.51 HCN4 SCN5A
12 inward rectifier potassium channel activity GO:0005242 9.49 KCNE2 KCNH2
13 voltage-gated potassium channel activity GO:0005249 9.35 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
14 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Sources for Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....