MCID: ATR057
MIFTS: 54

Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Atrioventricular Block

MalaCards integrated aliases for Atrioventricular Block:

Name: Atrioventricular Block 12 30 56 6 45 15 74
Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050820
ICD9CM 36 426.10
MeSH 45 D054537
NCIt 51 C26703
SNOMED-CT 69 58547007
ICD10 34 I44.3 I44.30
UMLS 74 C0004245

Summaries for Atrioventricular Block

Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to second-degree atrioventricular block and third-degree atrioventricular block. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Cardiac conduction. The drugs Aspirin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are Decreased shRNA abundance and cardiovascular system

Wikipedia : 77 Atrioventricular block (AV block) is a type of heart block in which the conduction between the atria and... more...

Related Diseases for Atrioventricular Block

Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 second-degree atrioventricular block 34.5 HCN4 LMNA
2 third-degree atrioventricular block 34.1 HCN4 KCNE2 NPPB SCN5A
3 progressive familial heart block 31.9 SCN5A TRPM4
4 syncope 31.1 KCNH2 KCNQ1 NPPB SCN5A
5 inferior myocardial infarction 30.8 NPPB PIK3C2A
6 sick sinus syndrome 30.8 HCN4 LMNA SCN5A
7 left bundle branch hemiblock 30.6 NPPB SCN5A
8 cardiogenic shock 30.5 NPPB PIK3C2A
9 wolff-parkinson-white syndrome 30.4 KCNQ1 NKX2-5 NPPB
10 sinoatrial node disease 30.4 HCN4 SCN5A
11 atrial standstill 1 30.3 LMNA NPPB SCN5A
12 ventricular septal defect 30.2 GATA4 NKX2-5 NPPB TBX5
13 atrial heart septal defect 30.2 GATA4 NKX2-5 TBX5
14 right bundle branch block 30.2 HCN4 SCN5A TRPM4
15 mitral valve insufficiency 30.1 NPPB TBX5
16 cardiac conduction defect 30.0 KCNH2 KCNQ1 LMNA SCN5A
17 cardiac arrest 30.0 KCNH2 KCNQ1 NPPB PIK3C2A SCN5A
18 ventricular fibrillation, paroxysmal familial, 1 29.7 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5 SCN5A
19 left ventricular noncompaction 29.6 HCN4 KCNQ1 LMNA NKX2-5 SCN5A
20 tetralogy of fallot 29.5 GATA4 KCNH2 NKX2-5 NPPB TBX5
21 atrial fibrillation 29.4 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 NPPB
22 long qt syndrome 29.4 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
23 dilated cardiomyopathy 28.6 CRYAB GATA4 KCNH2 KCNQ1 LMNA NKX2-5
24 brugada syndrome 28.5 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
25 heart disease 28.2 GATA4 HCN4 KCNE2 KCNH2 KCNQ1 LMNA
26 first-degree atrioventricular block 12.8
27 mobitz type ii atrioventricular block 12.5
28 heart block, congenital 11.8
29 progressive familial heart block, type ia 11.5
30 cardiac arrhythmia with increased serum creatine kinase 11.2
31 myocardial infarction 10.8
32 acute myocardial infarction 10.6
33 myocarditis 10.6
34 cardiac sarcoidosis 10.5
35 lymphoma 10.4
36 rere-related disorders 10.4
37 hypertrophic cardiomyopathy 10.4
38 endocarditis 10.3
39 brugada syndrome 1 10.3 KCNH2 SCN5A
40 acute myocarditis 10.3
41 familial short qt syndrome 10.3 KCNH2 KCNQ1
42 arrhythmogenic right ventricular dysplasia, familial, 5 10.3 NKX2-5 SCN5A
43 ischemia 10.3
44 arteries, anomalies of 10.3
45 coronary artery anomaly 10.3
46 myopathy 10.3
47 familial sick sinus syndrome 10.3 HCN4 SCN5A
48 pulmonary valve stenosis 10.2 GATA4 SCN5A
49 infective endocarditis 10.2
50 double discordia 10.2

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Aortic Valve Disease 1
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:



Diseases related to Atrioventricular Block

Symptoms & Phenotypes for Atrioventricular Block

GenomeRNAi Phenotypes related to Atrioventricular Block according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.92 KCNH2 KCNQ1 PIK3C2A TRPM4

MGI Mouse Phenotypes related to Atrioventricular Block:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 GATA4 HCN4 KCNH2 KCNQ1 LMNA NKX2-5
2 growth/size/body region MP:0005378 9.81 GATA4 KCNE2 KCNH2 KCNQ1 LMNA NKX2-5
3 muscle MP:0005369 9.61 CRYAB GATA4 HCN4 KCNH2 KCNQ1 LMNA
4 normal MP:0002873 9.17 GATA4 HCN4 KCNQ1 LMNA NKX2-5 SCN5A

Drugs & Therapeutics for Atrioventricular Block

Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 210)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Ticagrelor Approved Phase 4 274693-27-5 9871419
4
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
5
Ramipril Approved Phase 4 87333-19-5 5362129
6
Bisoprolol Approved Phase 4,Phase 3,Phase 2 66722-44-9 2405
7
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
8
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
9
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
10
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
11
Tenecteplase Approved Phase 4 191588-94-0
12
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
13
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
14
Atenolol Approved Phase 4 29122-68-7 2249
15
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
16
Polyestradiol phosphate Approved Phase 4 28014-46-2
17
Ofloxacin Approved Phase 4 82419-36-1 4583
18
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
19
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
20
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
21
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
22
Remifentanil Approved Phase 4 132875-61-7 60815
23
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
24
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
26
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 4 8001-79-4
27 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
28 calcium heparin Phase 4
29 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Nutrients Phase 4
31 Vitamin B Complex Phase 4,Phase 2
32 Trace Elements Phase 4
33 Vitamins Phase 4
34 Micronutrients Phase 4
35 Vitamin B9 Phase 4,Phase 2
36 Folate Phase 4,Phase 2
37 Antihypertensive Agents Phase 4,Phase 3,Phase 2
38 Platelet Aggregation Inhibitors Phase 4,Phase 2
39 Immunologic Factors Phase 4,Phase 3
40 Immunosuppressive Agents Phase 4,Phase 3
41 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Anti-Infective Agents Phase 4,Phase 3,Phase 2
44 Anti-Infective Agents, Urinary Phase 4,Phase 2
45 Renal Agents Phase 4,Phase 2
46 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Fingolimod Hydrochloride Phase 4
48 Epithelial Sodium Channel Blockers Phase 4
49 Sympatholytics Phase 4,Phase 3,Phase 2
50 Sodium Potassium Chloride Symporter Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 184)
# Name Status NCT ID Phase Drugs
1 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
2 Ventricular Pacing Site Selection (V-PASS) Unknown status NCT00292383 Phase 4
3 Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
4 Effect of Nicorandil for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4 Nicorandil;normal saline
5 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
6 Comparative Study Between Cryoablation and Radiofrequency Ablation in the Treatment of Supraventricular Tachycardia Unknown status NCT01584154 Phase 4
7 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
8 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
9 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
10 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
11 Biventricular Alternative Pacing Withdrawn NCT00559143 Phase 4
12 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) Completed NCT00621621 Phase 4
13 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
14 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) Completed NCT01585298 Phase 4 FTY720
15 Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension Recruiting NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
16 Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker Indication Completed NCT00562107 Phase 4
17 STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction Recruiting NCT02777580 Phase 4 Tenecteplase;Clopidogrel
18 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
19 Magnetically Navigated vs. Manually Guided Radiofrequency in Atrioventricular-node-reentry-tachycardia Completed NCT00875914 Phase 4
20 Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART) Recruiting NCT03278509 Phase 4 Metoprolol Succinate;Bisoprolol
21 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Levofloxacin
22 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation Completed NCT01474213 Phase 4 dexmedetomidine group;remifentanil group
23 Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial. Completed NCT01311700 Phase 4 Injectable (i.v.) metoprolol tartrate (up to 15 mg).
24 Safety and Effectiveness of Drug up Titration by Nurses Specialized in Heart Failure (HF) Patients Recruiting NCT02546856 Phase 4
25 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
26 First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) Unknown status NCT00392054 Phase 3 Conventional Antiarrhythmic Drug Therapy
27 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3 Benznidazole;Placebo
28 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
29 Safety Profile of IntRAvenous Lidocaine Use in Coelioscopic Bariatric Surgery Completed NCT02525016 Phase 3 Lidocaine
30 Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Completed NCT02386358 Phase 3 Benznidazole;Placebo
31 Transcatheter Aortic Valve Replacement Single Center Registry in Chinese Population Not yet recruiting NCT02803294 Phase 3
32 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3 Bisoprolol
33 Efficacy and Safety Study of Total Flavonoids of Propolis Dropping Pill to Treat Angina Pectoris Completed NCT01453582 Phase 3 Total Flavonoids of Propolis dropping pill;total Flavonoids of Propolis dropping pill
34 Bisoprolol in DMD Early Cardiomyopathy Recruiting NCT03779646 Phase 2, Phase 3 Bisoprolol Fumarate
35 Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of Alzheimer's Type Completed NCT01438060 Phase 3 Aripiprazole (BMS-337039);Placebo
36 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944970 Phase 3 binodenoson;adenosine
37 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944294 Phase 3 binodenoson;adenosine
38 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
39 Aripiprazole for Schizophrenia Outpatients Completing BMS Clinical Trials Completed NCT00239356 Phase 3 Aripiprazole
40 A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT) Completed NCT01618669 Phase 3 Regadenoson
41 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
42 Second Study on Cardio-neuromodulation in Humans Unknown status NCT02954666 Phase 2
43 Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler Unknown status NCT01593644 Phase 2 adenosine + dipyridamole
44 Ablation of Paroxysmal Atrial Fibrillation Using the Appropriate Contact Force in a Chinese Population Unknown status NCT02493075 Phase 1, Phase 2
45 Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania Unknown status NCT02909712 Phase 2 sulfadoxine-pyrimethamine (SP);dihydroartemisinin-piperaquine (DHA-PQP)
46 Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker Completed NCT01945606 Phase 2 Placebo (treatment 1);BAY1067197 (treatment 2)
47 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Recruiting NCT01379573 Phase 2 Hydroxychloroquine
48 Safety and Feasibility of Intracoronary Hypothermia in Acute Myocardial Infarction Completed NCT02753478 Phase 1, Phase 2
49 Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH). Recruiting NCT03338998 Phase 2 BAF312;Placebo
50 Adjunctive Ganglionated Plexus Ablation in Redo-Pulmonary Vein Isolation Recruiting NCT03535818 Phase 2

Search NIH Clinical Center for Atrioventricular Block

Cochrane evidence based reviews: atrioventricular block

Genetic Tests for Atrioventricular Block

Genetic tests related to Atrioventricular Block:

# Genetic test Affiliating Genes
1 Atrioventricular Block 30

Anatomical Context for Atrioventricular Block

MalaCards organs/tissues related to Atrioventricular Block:

42
Heart, Testes, Atrioventricular Node, Kidney, Brain, Lung, B Cells

Publications for Atrioventricular Block

Articles related to Atrioventricular Block:

(show top 50) (show all 2153)
# Title Authors Year
1
Atrioventricular block can be used as a risk predictor of clinical atrial fibrillation. ( 30801746 )
2019
2
Reversible mechanical atrioventricular block during cryoablation for paroxysmal atrial fibrillation with a 28 mm balloon. ( 30693198 )
2019
3
The Lotus Valve Is Safe and Effective, But Will Atrioventricular Block Improve With the Next-Generation System? ( 30621977 )
2019
4
Risk factors for atrioventricular block after transcatheter aortic valve implantation: a single-centre analysis including assessment of aortic calcifications and follow-up. ( 30629159 )
2019
5
Aripiprazole overdose and transient 2:1 second degree atrioventricular block: only a coincidence? ( 30659549 )
2019
6
Atrioventricular Block During Catheter Ablation for Ventricular Arrhythmias. ( 30678774 )
2019
7
Paradoxical nonreentrant tachycardia induced by iatrogenic atrioventricular block. ( 30735477 )
2019
8
Case report: Atrioventricular block after transcatheter atrial septal closure using the Figulla® Flex II ASD occluder. ( 30773790 )
2019
9
Rescue Percutaneous Coronary Intervention for a Lethal "Jailed" Septal Perforator Branch to Resolve Delayed Complete Atrioventricular Block. ( 30799381 )
2019
10
A rare case of Staphylococcus lugdunensis septicemia associated with myocarditis and atrioventricular block. ( 30800154 )
2019
11
A 2:1 atrioventricular block presenting paradoxical ventriculophasic response. ( 30888696 )
2019
12
His-bundle pacing in a patient with dextrocardia, severe systolic dysfunction, and complete atrioventricular block. ( 30891412 )
2019
13
Appropriate use of genetics in a young patient with atrioventricular block and family history of sudden cardiac death. ( 30891417 )
2019
14
Potential usage of cardioneuroablation in vagally mediated functional atrioventricular block. ( 30906551 )
2019
15
Gerbezius' Pulsus Mira Inconstantia and the First Descriptions of the Atrioventricular Block. ( 29784478 )
2018
16
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2018
17
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )
2018
18
Chronic Apical and Nonapical Right Ventricular Pacing in Patients with High-Grade Atrioventricular Block: Results of the Right Pace Study. ( 29951525 )
2018
19
High Grade Atrioventricular Block in Von Recklinghausen Disease: A Rare Phenomenon. ( 29904455 )
2018
20
Major determinant of the occurrence of pacing-induced cardiomyopathy in complete atrioventricular block: a multicentre, retrospective analysis over a 15-year period in South Korea. ( 29439074 )
2018
21
Marked First-Degree Atrioventricular Block and Pseudo-Pacemaker Syndrome in a Pediatric Patient. ( 29435607 )
2018
22
Second-degree Atrioventricular Block: Conceptions and Misconceptions. ( 29977560 )
2018
23
Atrioventricular block after acute myocardial infarction and its association with other clinical parameters in Pakistani patients: an institutional perspective. ( 29784020 )
2018
24
An extremely rare clinical entity: congenitally corrected transposition with situs A+nversus and single coronary artery presented with complete atrioventricular block in a young man. ( 29428001 )
2018
25
Importance of Early Diagnosis of Cardiac Sarcoidosis in Patients with Complete Atrioventricular Block. ( 29794391 )
2018
26
Complete Atrioventricular Block in an Elderly Patient Treated with Low-Dose Lacosamide. ( 29948594 )
2018
27
Lyme carditis and atrioventricular block. ( 29789287 )
2018
28
An unusual case of complete atrioventricular block causing Takotsubo syndrome. ( 29325979 )
2018
29
Recovery of High Degree Atrioventricular Block in a Patient with Cardiac Sarcoidosis by Corticosteroid Therapy. ( 29399570 )
2018
30
Cardiac resynchronization therapy improves left ventricular remodeling and function compared with right ventricular pacing in patients with atrioventricular block. ( 29968221 )
2018
31
Wide QRS complex tachycardia followed by 2:1 atrioventricular block: What is the mechanism? ( 29328513 )
2018
32
Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome. ( 29350247 )
2018
33
Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs. ( 29753687 )
2018
34
Cardiac pacing for complete atrioventricular block complicating heart lymphoma: A challenging issue. ( 29933920 )
2018
35
Progression of intrahisian atrioventricular block: Will this presage a renaissance of His-bundle studies? ( 29758403 )
2018
36
Impact of high-grade Atrioventricular block and cumulative frequent pacing on atrial arrhythmias. ( 29931776 )
2018
37
Adenosine hypersensitivity and atrioventricular block. ( 29845316 )
2018
38
Prediction of Delayed Atrioventricular Block and Pacemaker Implantation After Transcatheter Aortic Valve Replacement With CoreValve. ( 29223288 )
2018
39
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring. ( 29877257 )
2018
40
A Case of Atrioventricular Block Potentially Associated with Right Coronary Artery Lesion and Ticagrelor Therapy Mediated by the Increasing Adenosine Plasma Concentration. ( 29850368 )
2018
41
Slow pathway modification for treatment of pseudo-pacemaker syndrome due to first-degree atrioventricular block with dual atrioventricular nodal physiology. ( 29707483 )
2018
42
Risperidone-Associated Atrioventricular Block. ( 29927774 )
2018
43
A Case of Congenital Complete Atrioventricular Block Treated with Transdermal Tulobuterol. ( 29955022 )
2018
44
Echocardiographic assessment of ventricular contraction and synchrony in children with isolated complete atrioventricular block and epicardial pacing: Implications of interventricular mechanical delay. ( 29808935 )
2018
45
High-grade atrioventricular block in patients with acute myocardial infarction. Insights from a contemporary multi-center survey. ( 29550105 )
2018
46
Dynamic Electrocardiography is Useful in the Diagnosis of Persistent Atrial Fibrillation Accompanied with Second-Degree Atrioventricular Block. ( 30271091 )
2018
47
Ablative care of atrioventricular block: Uncovering new horizons or chasing ghosts. ( 28923352 )
2018
48
Exercise induced complete atrioventricular block: Utility of exercise stress test. ( 29042058 )
2018
49
Prognostic value of fluorine-18 fluoro-2-deoxyglucose positron emission computed tomography in patients with unexplained atrioventricular block. ( 29061522 )
2018
50
Exercise-induced Atrioventricular Block with Coronary Artery Stenosis that Appeared Five Years after Bypass Surgery. ( 29093419 )
2018

Variations for Atrioventricular Block

ClinVar genetic disease variations for Atrioventricular Block:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh37 Chromosome 3, 38595800: 38595800
2 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh38 Chromosome 3, 38554309: 38554309
3 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh37 Chromosome 3, 38651267: 38651267
4 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh38 Chromosome 3, 38609776: 38609776

Expression for Atrioventricular Block

Search GEO for disease gene expression data for Atrioventricular Block.

Pathways for Atrioventricular Block

Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 KCNE1 KCNQ1 SCN5A TRPM4
2
Show member pathways
12.29 GATA4 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5
3
Show member pathways
12.22 GATA4 NKX2-5 NPPB TBX5
4 12.11 KCNE1 KCNE2 KCNH2 KCNQ1
5
Show member pathways
11.98 GATA4 NKX2-5 TBX5
6 11.91 KCNH2 KCNQ1 SCN5A
7
Show member pathways
11.86 HCN4 KCNH2 KCNQ1
8 11.79 GATA4 NKX2-5 TBX5
9
Show member pathways
11.43 KCNE1 KCNE2 KCNQ1 SCN5A
10 11.24 GATA4 NKX2-5 TBX5
11 11.18 GATA4 NKX2-5 SCN5A TBX5
12 10.92 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 LMNA
13 10.89 GATA4 NKX2-5 NPPB
14 10.78 HCN4 KCNE1 KCNQ1
15 10.21 GATA4 NKX2-5

GO Terms for Atrioventricular Block

Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 CRYAB KCNE1 KCNE2 KCNH2 SCN5A
2 Z disc GO:0030018 9.33 CRYAB KCNE1 SCN5A
3 voltage-gated potassium channel complex GO:0008076 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.91 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
2 regulation of ion transmembrane transport GO:0034765 9.91 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
3 potassium ion transmembrane transport GO:0071805 9.88 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
4 regulation of membrane potential GO:0042391 9.86 HCN4 KCNH2 TRPM4
5 cellular response to drug GO:0035690 9.82 KCNE2 KCNH2 KCNQ1
6 cellular response to cAMP GO:0071320 9.8 HCN4 KCNE1 KCNQ1
7 cardiac muscle contraction GO:0060048 9.8 KCNH2 KCNQ1 NKX2-5 SCN5A
8 cardiac muscle cell differentiation GO:0055007 9.77 GATA4 NKX2-5 TBX5
9 regulation of potassium ion transmembrane transport GO:1901379 9.76 KCNE1 KCNE2 KCNH2
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.75 KCNE1 KCNE2 SCN5A
11 positive regulation of potassium ion transmembrane transport GO:1901381 9.74 KCNE1 KCNH2 KCNQ1
12 atrial septum morphogenesis GO:0060413 9.73 GATA4 NKX2-5 TBX5
13 regulation of membrane repolarization GO:0060306 9.72 KCNE2 KCNH2 KCNQ1
14 potassium ion export across plasma membrane GO:0097623 9.71 KCNE1 KCNE2 KCNH2 KCNQ1
15 regulation of heart rate GO:0002027 9.7 HCN4 SCN5A
16 ventricular septum development GO:0003281 9.7 GATA4 TBX5
17 positive regulation of heart rate GO:0010460 9.7 KCNQ1 TRPM4
18 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.7 KCNE1 KCNH2 KCNQ1
19 regulation of cardiac muscle contraction GO:0055117 9.69 HCN4 NKX2-5
20 cardiovascular system development GO:0072358 9.69 KCNQ1 NKX2-5
21 membrane depolarization during action potential GO:0086010 9.68 KCNH2 SCN5A
22 positive regulation of sodium ion transport GO:0010765 9.68 NKX2-5 SCN5A
23 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.68 KCNE1 KCNE2
24 sodium ion import across plasma membrane GO:0098719 9.68 HCN4 TRPM4
25 endocardial cushion development GO:0003197 9.67 GATA4 TBX5
26 regulation of cardiac muscle cell contraction GO:0086004 9.67 GATA4 SCN5A
27 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.67 HCN4 SCN5A
28 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNE1 KCNE2 KCNH2 KCNQ1
29 cardiac ventricle morphogenesis GO:0003208 9.66 GATA4 NKX2-5
30 ventricular cardiac muscle cell development GO:0055015 9.66 LMNA NKX2-5
31 atrial cardiac muscle cell action potential GO:0086014 9.65 KCNQ1 SCN5A
32 regulation of delayed rectifier potassium channel activity GO:1902259 9.65 KCNE1 KCNE2
33 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.64 KCNQ1 SCN5A
34 SA node cell action potential GO:0086015 9.63 HCN4 SCN5A
35 positive regulation of cardioblast differentiation GO:0051891 9.63 GATA4 NKX2-5 TBX5
36 membrane depolarization during AV node cell action potential GO:0086045 9.62 SCN5A TRPM4
37 membrane depolarization during SA node cell action potential GO:0086046 9.62 HCN4 SCN5A
38 membrane repolarization GO:0086009 9.62 KCNE1 KCNE2 KCNH2 KCNQ1
39 bundle of His development GO:0003166 9.61 NKX2-5 TBX5
40 membrane depolarization during bundle of His cell action potential GO:0086048 9.61 SCN5A TRPM4
41 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.6 SCN5A TRPM4
42 membrane repolarization during action potential GO:0086011 9.56 KCNE1 KCNE2 KCNH2 KCNQ1
43 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.55 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
44 ventricular cardiac muscle cell action potential GO:0086005 9.35 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
45 regulation of heart rate by cardiac conduction GO:0086091 9.17 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
46 ion transport GO:0006811 10.08 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
47 transmembrane transport GO:0055085 10.05 HCN4 KCNH2 KCNQ1 SCN5A TRPM4

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.76 HCN4 KCNH2 SCN5A TRPM4
2 voltage-gated ion channel activity GO:0005244 9.72 HCN4 KCNE2 KCNH2 KCNQ1 SCN5A
3 calmodulin binding GO:0005516 9.71 KCNQ1 SCN5A TRPM4
4 ion channel binding GO:0044325 9.71 KCNE1 KCNE2 KCNQ1 SCN5A
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.7 GATA4 NKX2-5 TBX5
6 scaffold protein binding GO:0097110 9.65 KCNH2 KCNQ1 SCN5A
7 sodium channel activity GO:0005272 9.61 HCN4 SCN5A TRPM4
8 delayed rectifier potassium channel activity GO:0005251 9.56 KCNE1 KCNE2 KCNH2 KCNQ1
9 potassium channel activity GO:0005267 9.55 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
10 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.54 KCNE1 KCNH2 KCNQ1
11 inward rectifier potassium channel activity GO:0005242 9.51 KCNE2 KCNH2
12 voltage-gated sodium channel activity GO:0005248 9.49 HCN4 SCN5A
13 voltage-gated potassium channel activity GO:0005249 9.35 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
14 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Sources for Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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