Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Atrioventricular Block

MalaCards integrated aliases for Atrioventricular Block:

Name: Atrioventricular Block 12 29 54 6 43 15 71
Av Block 12 15


External Ids:

Disease Ontology 12 DOID:0050820
ICD9CM 34 426.10
MeSH 43 D054537
NCIt 49 C26703
SNOMED-CT 67 233917008
ICD10 32 I44.3
UMLS 71 C0004245

Summaries for Atrioventricular Block

Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to first-degree atrioventricular block and second-degree atrioventricular block. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. The drugs Nebivolol and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Atrioventricular block (AV block) is a type of heart block that occurs when the electrical signal... more...

Related Diseases for Atrioventricular Block

Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 528)
# Related Disease Score Top Affiliating Genes
1 first-degree atrioventricular block 35.1 SCN5A NPPB MYH7 LMNA
2 second-degree atrioventricular block 34.4 TRIM21 SSB SCN5A HCN4 CA5B
3 third-degree atrioventricular block 33.9 TTN TRIM21 SSB SCN5A NPPB KCNH2
4 progressive familial heart block, type ia 33.4 TTN SCN5A SCN1A
5 long qt syndrome 14 32.5 SCN5A KCNQ1 KCNH2 KCNE1
6 progressive familial heart block 32.3 TRPM4 SCN5A NKX2-5 KCNQ1 KCNH2
7 syncope 32.1 TTN SCN5A KCNQ1 KCNH2
8 cardiogenic shock 31.4 PIK3C2A NPPB
9 sick sinus syndrome 31.4 TTN SCN5A LMNA KCNQ1 HCN4
10 heart septal defect 31.4 TBX5 NKX2-5 GATA4 CA5B
11 inferior myocardial infarction 31.4 PIK3C2A NPPB CA5B
12 left bundle branch hemiblock 31.2 SCN5A PIK3C2A NPPB LMNA CA5B
13 mitral valve insufficiency 31.2 TBX5 PIK3C2A NPPB
14 cardiac conduction defect 31.2 SCN5A MYH7 LMNA KCNQ1 KCNH2
15 right bundle branch block 31.1 TRPM4 SCN5A NPPB KCNH2 HCN4 CA5B
16 ventricular septal defect 31.1 TBX5 NPPB NKX2-5 MYH7 GATA4
17 ventricular fibrillation, paroxysmal familial, 1 31.0 SCN5A NKX2-5 KCNQ1 KCNH2 KCNE2 KCNE1
18 dextro-looped transposition of the great arteries 31.0 TBX5 NPPB NKX2-5 GATA4
19 atrial standstill 1 31.0 TTN SCN5A NPPB MYH7 LMNA GATA4
20 familial long qt syndrome 30.9 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
21 hypokalemia 30.9 PIK3C2A KCNQ1 KCNH2
22 cardiac arrhythmia 30.8 SCN5A KCNQ1 KCNH2 KCNE2
23 tricuspid atresia 30.8 TBX5 NKX2-5 GATA4
24 sinoatrial node disease 30.7 TBX5 SCN5A NKX2-5 KCNQ1 KCNH2 KCNE2
25 atrial heart septal defect 30.6 TTN TBX5 SCN5A NPPB NKX2-5 MYH7
26 lipoprotein quantitative trait locus 30.5 SCN5A PIK3C2A NPPB NKX2-5 KCNH2 GATA4
27 hypoplastic left heart syndrome 30.5 TBX5 NPPB NKX2-5 GATA4
28 muscular dystrophy 30.5 TTN PIK3C2A NKX2-5 MYH7 LMNA CRYAB
29 restrictive cardiomyopathy 30.4 TTN TRPM4 NPPB MYH7 LMNA CRYAB
30 peripartum cardiomyopathy 30.4 TTN SCN5A MYH7
31 patent ductus arteriosus 1 30.4 TBX5 NPPB NKX2-5 GATA4
32 long qt syndrome 30.4 TTN TRPM4 SCN5A MYH7 LMNA KCNQ1
33 endocardial fibroelastosis 30.3 TRIM21 SSB NPPB MYH7 CA5B
34 long qt syndrome 3 30.3 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
35 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 30.3 SCN5A MYH7 KCNQ1 KCNH2
36 congestive heart failure 30.3 TTN SCN5A PIK3C2A NPPB MYH7 LMNA
37 cardiac arrest 30.3 TTN TRPM4 SCN5A PIK3C2A NPPB MYH7
38 respiratory failure 30.3 TTN PIK3C2A NPPB MYH7 GATA4
39 aortic valve disease 2 30.3 TTN TBX5 NPPB NKX2-5 MYH7 GATA4
40 double outlet right ventricle 30.3 TBX5 NKX2-5 GATA4
41 atrioventricular septal defect 30.2 TBX5 NKX2-5 GATA4
42 aortic valve disease 1 30.2 TBX5 NKX2-5 HCN4 GATA4
43 tetralogy of fallot 30.2 TBX5 SCN5A NPPB NKX2-5 KCNH2 GATA4
44 miyoshi muscular dystrophy 30.1 TTN PIK3C2A MYH7
45 jervell and lange-nielsen syndrome 1 30.1 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
46 atrial fibrillation 30.1 TTN TBX5 SCN5A NPPB MYH7 LMNA
47 long qt syndrome 2 30.1 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
48 wolff-parkinson-white syndrome 30.0 TBX5 SCN5A NPPB NKX2-5 MYH7 KCNQ1
49 neuromuscular disease 30.0 TTN SCN5A MYH7 LMNA KCNH2 CRYAB
50 ebstein anomaly 29.7 TBX5 SCN5A NPPB NKX2-5 MYH7 HCN4

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 13)

Acute Cystitis Aortic Valve Disease 1
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:

Diseases related to Atrioventricular Block

Symptoms & Phenotypes for Atrioventricular Block

GenomeRNAi Phenotypes related to Atrioventricular Block according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.7 PIK3C2A
2 Decreased viability GR00055-A-2 9.7 PIK3C2A
3 Decreased viability GR00055-A-3 9.7 PIK3C2A
4 Decreased viability GR00221-A-1 9.7 PIK3C2A
5 Decreased viability GR00221-A-2 9.7 PIK3C2A TTN
6 Decreased viability GR00221-A-4 9.7 PIK3C2A TTN
7 Decreased viability GR00240-S-1 9.7 LMNA PIK3C2A TRIM21
8 Decreased viability GR00249-S 9.7 KCNE2 LMNA PIK3C2A TRPM4
9 Decreased viability GR00342-S-1 9.7 PIK3C2A TTN
10 Decreased viability GR00342-S-2 9.7 PIK3C2A
11 Decreased viability GR00342-S-3 9.7 PIK3C2A TTN
12 Decreased viability GR00386-A-1 9.7 LMNA
13 Decreased viability GR00402-S-2 9.7 KCNE2 KCNQ1 SCN5A

MGI Mouse Phenotypes related to Atrioventricular Block:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 GATA4 HCN4 KCNH2 KCNQ1 LMNA MYH7
2 growth/size/body region MP:0005378 10.1 CA5B GATA4 KCNE2 KCNH2 KCNQ1 LMNA
3 homeostasis/metabolism MP:0005376 10.1 CA5B CRYAB GATA4 KCNE2 KCNH2 KCNQ1
4 mortality/aging MP:0010768 10 CA5B GATA4 HCN4 KCNH2 LMNA MYH7
5 muscle MP:0005369 9.7 CRYAB GATA4 HCN4 KCNH2 KCNQ1 LMNA
6 normal MP:0002873 9.32 GATA4 HCN4 KCNQ1 LMNA MYH7 NKX2-5

Drugs & Therapeutics for Atrioventricular Block

Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 131)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Nebivolol Approved, Investigational Phase 4 99200-09-6, 118457-14-0, 152520-56-4 71301
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
Enalaprilat Approved Phase 4 76420-72-9 6917719
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
Bisoprolol Approved Phase 4 66722-44-9 2405
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Ticagrelor Approved Phase 4 274693-27-5 9871419
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
Ramipril Approved Phase 4 87333-19-5 5362129
Remifentanil Approved Phase 4 132875-61-7 60815
Ephedrine Approved Phase 4 299-42-3 9294
Pseudoephedrine Approved Phase 4 90-82-4 7028
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Verapamil Approved Phase 4 52-53-9 2520
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
Procainamide Approved Phase 4 51-06-9 4913
Choline Approved, Nutraceutical Phase 4 62-49-7 305
29 Adrenergic beta-Agonists Phase 4
30 Angiotensin II Type 1 Receptor Blockers Phase 4
31 Angiotensinogen Phase 4
32 Giapreza Phase 4
33 Anesthetics Phase 4
34 Anesthetics, General Phase 4
35 Analgesics, Non-Narcotic Phase 4
36 Hypnotics and Sedatives Phase 4
37 Anesthetics, Intravenous Phase 4
38 Cytidine Diphosphate Choline Phase 4
39 Adrenergic alpha-Antagonists Phase 4
40 Natriuretic Peptide, Brain Phase 4
41 Antioxidants Phase 4
42 Adrenergic alpha-1 Receptor Antagonists Phase 4
43 Protective Agents Phase 4
44 Anesthetics, Local Phase 4
45 Purinergic P2Y Receptor Antagonists Phase 4
46 Antipyretics Phase 4
47 Platelet Aggregation Inhibitors Phase 4
48 Cyclooxygenase Inhibitors Phase 4
49 Antirheumatic Agents Phase 4
50 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 169)
# Name Status NCT ID Phase Drugs
1 Randomized Clinical Study to Assess the Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
2 A Randomized, Prospective Multicenter Pilot Study to Determine the Influence of the Ventricular Pacing Site on the Incidence of Atrial Fibrillation and Heart Failure in Patients With Indication for Permanent Pacemaker Stimulation Therapy. Unknown status NCT00292383 Phase 4
3 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
4 IntAct, Study on Promotion of Intrinsic Activity. Unknown status NCT00156741 Phase 4
5 A Randomized, Prospective Multicenter Study to Determine the Incidence of Atrial Fibrillation and Heart Failure in Correlation to Stimulation Modes of Pacemakers Unknown status NCT00161551 Phase 4
6 Comparative Study of the Effects of Telmisartan and Nebivolol on 24-h Ambulatory Blood Pressure and Arterial Stiffness in Patients With Arterial Hypertension Unknown status NCT02057328 Phase 4 TELMISARTAN;NEBIVOLOL
7 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
8 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) Completed NCT00621621 Phase 4
9 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
10 PreFER MVP for Elective Replacement Completed NCT00293241 Phase 4
11 Nimodipine for Treating Acute Massive Cerebral Infarction: a Randomized, Double-blind, Controlled Clinical Study Completed NCT02248233 Phase 4 Nimodipine;Saline + citicoline
12 A Randomized Trial of Carvedilol After Renin-angiotensin System Inhibition in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
13 A Randomized, Double-Blind Comparison Of Dexmedetomidine And Remifentanil For Sedation During Awake Fiberoptic Intubations Completed NCT00349245 Phase 4 Remifentanil;Dexmedetomidine
14 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption, Cognitive Function and Incidence of Neuropathic Pain in Laparoscopic Intestine Resection Completed NCT02616523 Phase 4 Dexmedetomidine;Lidocaine;Fentanyl
15 Reversal of the Anti-platelet Effects of Ticagrelor in Healthy Persons and Patients With Coronary Artery Disease Completed NCT02383771 Phase 4 Ticagrelor;Aspirin + Ticagrelor;Control;Aspirin + Ticagrelor
16 Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT) Completed NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
17 Effects of Remifentanil on Diastolic and Systolic Function in Patients With Diastolic Dysfunction Recruiting NCT04117009 Phase 4 Remifentanil 2 MG
18 A Comparison Between Right Ventricular Apical Pacing and True Mid-septal Pacing, Verified With Computed Tomography: a Randomized Study Recruiting NCT02412176 Phase 4
19 Randomized Evaluation of Beta Blocker and Angiotensin Converting Enzyme Inhibitor (ACEI) /Angiotensin Receptor Blocker (ARB) Treatment in MINOCA Patients. Recruiting NCT03686696 Phase 4 Beta blocker;ACEI;ARB
20 Beta-blockeRs tO patieNts With CHronIc Obstructive puLmonary diseasE Recruiting NCT03566667 Phase 4 Metoprolol;Standard care
21 Atrioventricular Block and Cluster Headache Not yet recruiting NCT04406259 Phase 4 Verapamil
22 A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Not yet recruiting NCT02347111 Phase 4 Flecainide;Sotalol
23 Comparison of Intravenous Amiodarone Versus Intravenous Procainamide for the Acute Treatment of Regular and Haemodynamically Well Tolerated Wide QRS Tachycardia (Probably of Ventricular Origen). The PROCAMIO Multicenter Study Terminated NCT00383799 Phase 4 iv Amiodarone;iv Procainamide
24 Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock Terminated NCT02668432 Phase 4 Amiodarone
25 Better Pacing - Biventricular Pacing as Alternative Method in Patients With Disturbances of AV Conduction and Preserved LV Function Withdrawn NCT00559143 Phase 4
26 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
27 An Assessment of the Echo-guided Optimal Cardiac Resynchronization Therapy in Patients Undergoing 'Ablate And Pace' Therapy for Permanent Atrial Fibrillation Completed NCT00111527 Phase 3
28 A Prospective Canadian Multi-Center Randomized Study; Spontaneous AtrioVEntricular Conduction PReservation Completed NCT01219621 Phase 3
29 A Randomized Double-blind Placebo Force-titration Controlled Study With Bisoprolol in Patients With Chronic Heart Failure Secondary to Chagas´ Cardiomyopathy. Completed NCT00323973 Phase 3 Bisoprolol
30 Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem Completed NCT00319982 Phase 2, Phase 3 Diltiazem;Placebo
31 Safety and Efficacy of Dexmedetomidine in Painless Colonoscopy: a Single-center, Randomized, Single-blind Study Not yet recruiting NCT03892928 Phase 3 Dexmedetomidine group
32 Magnesium Sulfate Versus Dexmedetomidine on Anesthesia Awakening. Randomized Clinical Trial. Not yet recruiting NCT04300985 Phase 3 Dexmedetomidine;Sham treatment;Magnesium Sulfate
33 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
34 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2
35 Ablation of Paroxysmal Atrial Fibrillation Using the Appropriate Contact Force in a Chinese Population: A Prospective Randomized Single-center Trial Unknown status NCT02493075 Phase 1, Phase 2
36 Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery Completed NCT02498769 Phase 1, Phase 2 Botulinum Toxin Type A;Placebo
37 Efficacy of Antihypertensive and Plasma Total Homocysteine Lowering Combined Therapy With Enalapril and Folic Acid in Hypertensive Patients:A Multicenter Double Blind Randomized Clinical Trial Completed NCT00520247 Phase 2 enalapril plus folic acid
38 Combination of Hydroxyurea and Verapamil for Refractory Meningiomas Completed NCT00706810 Phase 2 Hydroxyurea;Verapamil
39 Adjunctive GP Ablation In Redo-PVI: Paroxysmal Atrial Arrhythmias After Pulmonary Vein Isolation Are Driven By Ectopy-Triggering Left Atrial Ganglionated Plexus Recruiting NCT03535818 Phase 2
40 Lidocaine Combined With Low Opioid Anesthesia and Analgesia Can Enhance Recovery After Surgery of Patients With Primary Liver Cancer: a Prospective Randomized Controlled Study Recruiting NCT04295330 Phase 2 Lidocaine Hydrochloride, Injectable;0.9% normal saline
41 A Phase II, Patient- and Investigator-blinded, Randomized, Placebo-controlled Study to Evaluate Efficacy, Safety and Tolerability of BAF312 (Siponimod) in Patients With Stroke Due to Intracerebral Hemorrhage (ICH) Suspended NCT03338998 Phase 2 BAF312;Placebo
42 A Randomised Controlled Trial of Combinating an Immune Modulator Fingolimod With Alteplase Bridging With Mechanical Thrombectomy in Acute Ischemic Stroke Withdrawn NCT02956200 Phase 2 Fingolimod
43 Micra Atrial Tracking Using a Ventricular Accelerometer Study Completed NCT03157297 Phase 1
44 Pharmacokinetics of Orally Administered Dasotraline in Subjects With Mild, Moderate, and Severe Hepatic Dysfunction Completed NCT02795637 Phase 1 dasotraline
45 Prospective Analysis of Low-Dose Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart Completed NCT02462941 Phase 1 Adenosine
46 A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Assess the Safety, Tolerability, and Electrocardiographic Effects of Lofexidine When Administered Orally to Methadone Maintained Adult Subjects Completed NCT01650649 Phase 1 Lofexidine HCl;Lofexidine-matching sugar pill
47 A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Assess the Safety, Tolerability, and Electrocardiographic Effects of Lofexidine When Administered Orally to Buprenorphine-Maintained Adult Subjects Completed NCT01820442 Phase 1 Lofexidine HCl;Lofexidine-matching sugar pill
48 Cohort Description of Younger With AV-block Unknown status NCT03024047
49 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
50 Effect of Atrioventricular Optimization on Left Ventricular Function With Dual Chamber Pacemaker; Prospective Randomized Trial Unknown status NCT03556189

Search NIH Clinical Center for Atrioventricular Block

Cochrane evidence based reviews: atrioventricular block

Genetic Tests for Atrioventricular Block

Genetic tests related to Atrioventricular Block:

# Genetic test Affiliating Genes
1 Atrioventricular Block 29

Anatomical Context for Atrioventricular Block

MalaCards organs/tissues related to Atrioventricular Block:

Heart, Atrioventricular Node, Testes, Brain, Kidney, Liver, Lung

Publications for Atrioventricular Block

Articles related to Atrioventricular Block:

(show top 50) (show all 10131)
# Title Authors PMID Year
Identification of a new lamin A/C mutation in a Chinese family affected with atrioventricular block as the prominent phenotype. 54 61
20155465 2010
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. 61 54
19546853 2009
Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. 61 54
19638735 2009
Plasma levels of B-type natriuretic peptide in children and adolescents with high degree atrioventricular block. 54 61
18485504 2009
A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death. 61 54
19328042 2009
Molecular and clinical characterization of a novel SCN5A mutation associated with atrioventricular block and dilated cardiomyopathy. 61 54
19808398 2008
Novel point mutation in the NKX2-5 gene in a Moroccan family with atrioventricular conduction disturbance and an atrial septal defect in the oval fossa. 54 61
17184575 2007
Effect of right ventricular apex pacing on the Tei index and brain natriuretic peptide in patients with a dual-chamber pacemaker. 61 54
16981923 2006
Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter. 61 54
15982494 2005
Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect. 54 61
15810002 2005
Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies. 61 54
15364612 2004
Function follows form: cardiac conduction system defects in Nkx2-5 mutation. 61 54
15368343 2004
[Neonatal forms of congenital long QT syndrome]. 54 61
15214551 2004
Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations. 54 61
14998624 2004
Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects. 61 54
12898247 2003
Congenital long QT syndrome and 2:1 atrioventricular block with a mutation of the SCN5A gene. 54 61
12574983 2003
Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. 61 54
11897440 2002
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. 54 61
11804990 2002
Homozygous SCN5A mutation in long-QT syndrome with functional two-to-one atrioventricular block. 61 54
11463728 2001
Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. 54 61
10587520 1999
[Temporal electric stimulation and right ventricular extension in acute postero-inferior myocardial infarction. Influence on clinical characteristics and prognosis]. 61 54
1807297 1991
Incidence and predictors of atrial fibrillation in a Chinese cohort of Brugada syndrome. 61
32387420 2020
Temporal trends in in-hospital complications of acute coronary syndromes: Insights from the nationwide AMIS Plus registry. 61
32305559 2020
Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs. 61
32499094 2020
In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys. 61
32499095 2020
Prevalence of permanent pacemaker implantation after conventional aortic valve replacement-a propensity-matched analysis in patients with a bicuspid or tricuspid aortic valve: a benchmark for transcatheter aortic valve replacement. 61
32211779 2020
Long-term Follow-up of Epicardial Pacing and Left Ventricular Dysfunction in Children With Congenital Heart Block. 61
31715154 2020
A Pharmacovigilance Study of Hydroxychloroquine Cardiac Safety Profile: Potential Implication in COVID-19 Mitigation. 61
32549293 2020
Cardiovascular manifestations in severe and critical patients with COVID-19. 61
32562427 2020
His-Purkinje Conduction System Pacing Following Transcatheter Aortic Valve Replacement: Feasibility and Safety. 61
32553214 2020
"Preventive" pacing in patients with tachy-brady syndrome (TBS): Confirming a common practice. 61
32533880 2020
Simplified, minimally invasive, beating-heart technique for redo isolated tricuspid valve surgery. 61
32552843 2020
Short-term and intermediate-term performance and safety of left bundle branch pacing. 61
32239598 2020
Network meta-analysis of His bundle, biventricular, or right ventricular pacing as a primary strategy for advanced atrioventricular conduction disease with normal or mildly reduced ejection fraction. 61
32275339 2020
Pacemaker and conduction disturbances in patients with atrial septal defect. 61
32498739 2020
Unplanned Thirty-Day Readmission After Alcohol Septal Ablation for Hypertrophic Cardiomyopathy (From the Nationwide Readmission Database). 61
32305221 2020
[Indications for His bundle and left bundle branch pacing]. 61
32385573 2020
Autopsy evaluation of the implantation site of a his bundle pacing lead demonstrating selective capture. 61
32548908 2020
Cardiac rhythm abnormalities - An underestimated cardiovascular risk in adult patients with Mucopolysaccharidoses. 61
32241717 2020
Immediate and long-term need for permanent cardiac pacing following aortic valve replacement. 61
31809597 2020
Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia. 61
32555258 2020
Ablation of atrioventricular-nodal-reentrant- tachycardia in a patient with left-sided superior vena cava and dilated coronary sinus. 61
32567577 2020
Fast pathway ablation in a patient with PR prolongation: A case report. 61
32533707 2020
Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction. 61
32520982 2020
Clinical predictors of all-cause mortality in patients presenting to specialist heart failure clinic with raised NT-proBNP and no heart failure. 61
32496010 2020
AV Block Post-TAVR: When AV Block Is High, We Go Low (in the Conduction System). 61
32553215 2020
Behavior of the PR Interval with Increasing Heart Rate in Patients with COVID-19. 61
32535142 2020
Long-term percentage of ventricular pacing in patients requiring pacemaker implantation after transcatheter aortic valve replacement. A multicenter 10 years' experience. 61
32512176 2020
Left ventricular (LV) pacing in newborns and infants: Echo assessment of LV systolic function and synchrony at 5-year follow-up. 61
32233121 2020
Direct left ventricular wire pacing during transcatheter aortic valve implantation. 61
32567288 2020

Variations for Atrioventricular Block

ClinVar genetic disease variations for Atrioventricular Block:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 SCN5A NM_198056.2(SCN5A):c.4783G>A (p.Asp1595Asn)SNV Pathogenic 9385 rs137854607 3:38595800-38595800 3:38554309-38554309
2 SCN5A NM_000335.5(SCN5A):c.892G>A (p.Gly298Ser)SNV Uncertain significance 9387 rs137854608 3:38651267-38651267 3:38609776-38609776

Expression for Atrioventricular Block

Search GEO for disease gene expression data for Atrioventricular Block.

Pathways for Atrioventricular Block

Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
5 11.66 TBX5 NKX2-5 GATA4
Show member pathways
7 11.35 TBX5 SCN5A NKX2-5 GATA4
8 11.3 TBX5 NKX2-5 GATA4
10 10.86 KCNQ1 KCNE1 HCN4
11 10.8 NPPB NKX2-5 MYH7 GATA4
12 10.26 NKX2-5 GATA4

GO Terms for Atrioventricular Block

Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 9.26 SCN5A SCN1A
2 voltage-gated potassium channel complex GO:0008076 9.26 KCNQ1 KCNH2 KCNE2 KCNE1
3 sodium channel complex GO:0034706 9.16 TRPM4 SCN1A
4 Z disc GO:0030018 9.1 TTN SCN5A SCN1A MYH7 KCNE1 CRYAB

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.13 TRPM4 SCN5A SCN1A KCNQ1 KCNH2 KCNE2
2 transmembrane transport GO:0055085 10.12 TRPM4 SCN5A SCN1A KCNQ1 KCNH2 HCN4
3 potassium ion transport GO:0006813 9.96 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
4 potassium ion transmembrane transport GO:0071805 9.95 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
5 regulation of membrane potential GO:0042391 9.92 TRPM4 SCN1A KCNH2 HCN4
6 muscle contraction GO:0006936 9.91 TTN MYH7 HCN4 CRYAB
7 regulation of ion transmembrane transport GO:0034765 9.91 SCN5A SCN1A KCNQ1 KCNH2 KCNE2 KCNE1
8 sodium ion transmembrane transport GO:0035725 9.86 SCN5A SCN1A HCN4
9 cellular response to drug GO:0035690 9.85 KCNQ1 KCNH2 KCNE2
10 cellular response to cAMP GO:0071320 9.84 KCNQ1 KCNE1 HCN4
11 potassium ion import across plasma membrane GO:1990573 9.82 KCNH2 KCNE2 HCN4
12 regulation of heart rate GO:0002027 9.8 SCN5A MYH7 HCN4
13 cardiac muscle cell action potential involved in contraction GO:0086002 9.8 SCN5A SCN1A KCNE2 KCNE1
14 cardiac muscle cell differentiation GO:0055007 9.78 TBX5 NKX2-5 GATA4
15 potassium ion export across plasma membrane GO:0097623 9.78 KCNQ1 KCNH2 KCNE2 KCNE1
16 regulation of potassium ion transmembrane transport GO:1901379 9.77 KCNH2 KCNE2 KCNE1
17 membrane depolarization during action potential GO:0086010 9.77 SCN5A SCN1A KCNH2
18 positive regulation of potassium ion transmembrane transport GO:1901381 9.76 KCNQ1 KCNH2 KCNE1
19 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.76 KCNQ1 KCNH2 KCNE2 KCNE1
20 atrial septum morphogenesis GO:0060413 9.75 TBX5 NKX2-5 GATA4
21 regulation of membrane repolarization GO:0060306 9.74 KCNQ1 KCNH2 KCNE2
22 membrane repolarization GO:0086009 9.73 KCNQ1 KCNH2 KCNE2 KCNE1
23 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.72 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
24 sodium ion import across plasma membrane GO:0098719 9.71 TRPM4 HCN4
25 striated muscle contraction GO:0006941 9.71 TTN MYH7
26 cardiovascular system development GO:0072358 9.71 NKX2-5 KCNQ1
27 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.71 KCNQ1 KCNH2 KCNE1
28 membrane repolarization during action potential GO:0086011 9.71 KCNQ1 KCNH2 KCNE2 KCNE1
29 positive regulation of sodium ion transport GO:0010765 9.7 SCN5A NKX2-5
30 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.7 KCNE2 KCNE1
31 cardiac muscle tissue morphogenesis GO:0055008 9.7 TTN NKX2-5
32 adult heart development GO:0007512 9.7 NKX2-5 MYH7
33 regulation of cardiac muscle cell contraction GO:0086004 9.69 SCN5A GATA4
34 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.69 SCN5A HCN4
35 endocardial cushion development GO:0003197 9.69 TBX5 GATA4
36 positive regulation of cardioblast differentiation GO:0051891 9.69 TBX5 NKX2-5 GATA4
37 ventricular cardiac muscle cell development GO:0055015 9.68 NKX2-5 LMNA
38 cardiac ventricle morphogenesis GO:0003208 9.68 NKX2-5 GATA4
39 atrial cardiac muscle cell action potential GO:0086014 9.68 SCN5A KCNQ1
40 regulation of delayed rectifier potassium channel activity GO:1902259 9.67 KCNE2 KCNE1
41 SA node cell action potential GO:0086015 9.66 SCN5A HCN4
42 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.66 SCN5A KCNQ1
43 membrane depolarization during SA node cell action potential GO:0086046 9.65 SCN5A HCN4
44 membrane depolarization during AV node cell action potential GO:0086045 9.65 TRPM4 SCN5A
45 ventricular cardiac muscle cell action potential GO:0086005 9.65 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
46 membrane depolarization during bundle of His cell action potential GO:0086048 9.64 TRPM4 SCN5A
47 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.63 TRPM4 SCN5A
48 bundle of His development GO:0003166 9.63 TBX5 NKX2-5
49 cardiac conduction GO:0061337 9.63 TRPM4 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
50 cardiac muscle contraction GO:0060048 9.43 TTN SCN5A NKX2-5 MYH7 KCNQ1 KCNH2

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.83 TTN TRPM4 SCN5A MYH7 KCNQ1
2 ion channel binding GO:0044325 9.8 SCN5A KCNQ1 KCNE2 KCNE1
3 ion channel activity GO:0005216 9.8 TRPM4 SCN5A SCN1A KCNQ1 KCNH2 HCN4
4 scaffold protein binding GO:0097110 9.69 SCN5A KCNQ1 KCNH2
5 delayed rectifier potassium channel activity GO:0005251 9.67 KCNQ1 KCNH2 KCNE2 KCNE1
6 sodium channel activity GO:0005272 9.65 SCN5A SCN1A HCN4
7 potassium channel activity GO:0005267 9.65 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
8 voltage-gated sodium channel activity GO:0005248 9.63 SCN5A SCN1A HCN4
9 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.58 KCNQ1 KCNH2 KCNE1
10 voltage-gated potassium channel activity GO:0005249 9.55 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
11 telethonin binding GO:0031433 9.52 TTN KCNE1
12 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.26 KCNQ1 KCNH2 KCNE2 KCNE1
13 voltage-gated ion channel activity GO:0005244 9.17 SCN5A SCN1A KCNQ1 KCNH2 KCNE2 KCNE1

Sources for Atrioventricular Block

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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