MCID: ATR057
MIFTS: 56

Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Atrioventricular Block

MalaCards integrated aliases for Atrioventricular Block:

Name: Atrioventricular Block 12 29 55 6 44 15 72
Av Block 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050820
ICD9CM 35 426.10
MeSH 44 D054537
NCIt 50 C26703
SNOMED-CT 68 58547007
ICD10 33 I44.3 I44.30
UMLS 72 C0004245

Summaries for Atrioventricular Block

Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to first-degree atrioventricular block and second-degree atrioventricular block. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Cardiac conduction. The drugs Nebivolol and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are Decreased shRNA abundance and cardiovascular system

Wikipedia : 75 Atrioventricular block (AV block) is a type of heart block in which the conduction between the atria and... more...

Related Diseases for Atrioventricular Block

Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 493)
# Related Disease Score Top Affiliating Genes
1 first-degree atrioventricular block 35.3 SCN5A MYH7
2 second-degree atrioventricular block 35.0 LMNA HCN4
3 third-degree atrioventricular block 33.7 TRIM21 SCN5A NPPB KCNE2 HCN4
4 progressive familial heart block 32.3 TRPM4 SCN5A
5 syncope 31.7 SCN5A NPPB KCNQ1 KCNH2
6 left bundle branch hemiblock 31.6 SCN5A NPPB
7 sick sinus syndrome 31.4 SCN5A LMNA HCN4
8 atrial standstill 1 31.2 SCN5A NPPB MYH7 LMNA
9 right bundle branch block 31.1 TRPM4 SCN5A HCN4
10 heart septal defect 31.1 TBX5 NKX2-5 GATA4
11 sinoatrial node disease 31.1 SCN5A HCN4
12 inferior myocardial infarction 30.9 PIK3C2A NPPB
13 atrial heart septal defect 30.8 TBX5 NKX2-5 GATA4
14 cardiogenic shock 30.7 PIK3C2A NPPB
15 wolff-parkinson-white syndrome 30.7 NPPB NKX2-5 MYH7 KCNQ1
16 cardiac conduction defect 30.7 SCN5A MYH7 LMNA KCNQ1 KCNH2
17 patent ductus arteriosus 1 30.3 NPPB NKX2-5 GATA4
18 restrictive cardiomyopathy 30.3 NPPB MYH7 CRYAB
19 aortic valve disease 2 30.3 TBX5 NPPB MYH7
20 ventricular septal defect 30.2 TBX5 NPPB NKX2-5 MYH7 GATA4
21 ventricular fibrillation, paroxysmal familial, 1 30.2 SCN5A NKX2-5 KCNQ1 KCNH2 KCNE2 KCNE1
22 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 30.0 SCN5A MYH7 KCNQ1 KCNH2
23 cardiac arrhythmia 29.9 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
24 atrioventricular septal defect 29.8 TBX5 NKX2-5 GATA4
25 ebstein anomaly 29.8 NPPB NKX2-5 MYH7 GATA4
26 tetralogy of fallot 29.7 TBX5 NPPB NKX2-5 KCNH2 GATA4
27 long qt syndrome 3 29.7 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
28 left ventricular noncompaction 29.6 SCN5A NKX2-5 MYH7 LMNA KCNQ1 HCN4
29 cardiac arrest 29.5 SCN5A PIK3C2A NPPB MYH7 KCNQ1 KCNH2
30 arrhythmogenic right ventricular cardiomyopathy 29.5 SCN5A MYH7 LMNA KCNH2 HCN4
31 jervell and lange-nielsen syndrome 1 29.4 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
32 long qt syndrome 2 29.4 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
33 long qt syndrome 29.3 TRPM4 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
34 atrial fibrillation 28.9 TBX5 SCN5A NPPB KCNQ1 KCNH2 KCNE2
35 familial atrial fibrillation 28.6 SCN5A NKX2-5 KCNQ1 KCNH2 KCNE2 KCNE1
36 brugada syndrome 28.5 TRPM4 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
37 dilated cardiomyopathy 28.1 TBX5 SCN5A NPPB NKX2-5 MYH7 LMNA
38 heart disease 26.4 TBX5 SCN5A PIK3C2A NPPB NKX2-5 MYH7
39 mobitz type ii atrioventricular block 12.7
40 heart block, congenital 12.2
41 progressive familial heart block, type ia 11.8
42 myocarditis 10.7
43 progressive familial heart block, type ib 10.7
44 acute myocardial infarction 10.7
45 sarcoidosis 1 10.6
46 congestive heart failure 10.6
47 myocardial infarction 10.6
48 cardiac sarcoidosis 10.6
49 brugada syndrome 1 10.5 SCN5A KCNH2
50 endocarditis 10.5

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Aortic Valve Disease 1
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:



Diseases related to Atrioventricular Block

Symptoms & Phenotypes for Atrioventricular Block

GenomeRNAi Phenotypes related to Atrioventricular Block according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.92 KCNH2 KCNQ1 PIK3C2A TRPM4

MGI Mouse Phenotypes related to Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 GATA4 HCN4 KCNH2 KCNQ1 LMNA MYH7
2 homeostasis/metabolism MP:0005376 9.85 GATA4 KCNE2 KCNH2 KCNQ1 LMNA NKX2-5
3 muscle MP:0005369 9.65 CRYAB GATA4 HCN4 KCNH2 KCNQ1 LMNA
4 normal MP:0002873 9.17 GATA4 HCN4 KCNQ1 LMNA NKX2-5 SCN5A

Drugs & Therapeutics for Atrioventricular Block

Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 157)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
2
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
3
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
4
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
5
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
6
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
7
tannic acid Approved Phase 4 1401-55-4
8
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
9
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
10
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
11
Enalaprilat Approved Phase 4 76420-72-9 6917719
12
Remifentanil Approved Phase 4 132875-61-7 60815
13
Bisoprolol Approved Phase 4 66722-44-9 2405
14
Ticagrelor Approved Phase 4 274693-27-5 9871419
15
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
16
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
17
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
18
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
19
Ramipril Approved Phase 4 87333-19-5 5362129
20
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
21
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
22
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
23
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
24
Procainamide Approved Phase 4 51-06-9 4913
25
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
26
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
27
Choline Approved, Nutraceutical Phase 4 62-49-7 305
28 Adrenergic beta-Agonists Phase 4
29 Sodium Chloride Symporter Inhibitors Phase 4
30 Giapreza Phase 4
31 Angiotensin II Type 1 Receptor Blockers Phase 4
32 Angiotensinogen Phase 4
33 Anti-Inflammatory Agents Phase 4
34 Hormones Phase 4
35 Hormone Antagonists Phase 4
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
37 Analgesics Phase 4
38 Analgesics, Non-Narcotic Phase 4
39 Adrenergic alpha-2 Receptor Agonists Phase 4
40 Adrenergic Agonists Phase 4
41 Adrenergic alpha-Agonists Phase 4
42 Central Nervous System Depressants Phase 4
43 Hypnotics and Sedatives Phase 4
44 Anesthetics, General Phase 4
45 Anesthetics Phase 4
46 Anesthetics, Intravenous Phase 4
47 calcium channel blockers Phase 4
48 Calcium, Dietary Phase 4
49 Nootropic Agents Phase 4
50 Cytidine Diphosphate Choline Phase 4

Interventional clinical trials:

(show top 50) (show all 147)
# Name Status NCT ID Phase Drugs
1 Randomized Clinical Study to Assess the Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
2 A Randomized, Prospective Multicenter Pilot Study to Determine the Influence of the Ventricular Pacing Site on the Incidence of Atrial Fibrillation and Heart Failure in Patients With Indication for Permanent Pacemaker Stimulation Therapy. Unknown status NCT00292383 Phase 4
3 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
4 A Randomized, Prospective Multicenter Study to Determine the Incidence of Atrial Fibrillation and Heart Failure in Correlation to Stimulation Modes of Pacemakers Unknown status NCT00161551 Phase 4
5 Comparative Study of the Effects of Telmisartan and Nebivolol on 24-h Ambulatory Blood Pressure and Arterial Stiffness in Patients With Arterial Hypertension Unknown status NCT02057328 Phase 4 TELMISARTAN;NEBIVOLOL
6 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
7 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) Completed NCT00621621 Phase 4
8 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
9 PreFER MVP for Elective Replacement Completed NCT00293241 Phase 4
10 Nimodipine for Treating Acute Massive Cerebral Infarction: a Randomized, Double-blind, Controlled Clinical Study Completed NCT02248233 Phase 4 Nimodipine;Saline + citicoline
11 A Randomized Trial of Carvedilol After Renin-angiotensin System Inhibition in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
12 A Randomized, Double-Blind Comparison Of Dexmedetomidine And Remifentanil For Sedation During Awake Fiberoptic Intubations Completed NCT00349245 Phase 4 Remifentanil;Dexmedetomidine
13 Reversal of the Anti-platelet Effects of Ticagrelor in Healthy Persons and Patients With Coronary Artery Disease Completed NCT02383771 Phase 4 Ticagrelor;Aspirin + Ticagrelor;Control;Aspirin + Ticagrelor
14 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption, Cognitive Function and Incidence of Neuropathic Pain in Laparoscopic Intestine Resection Completed NCT02616523 Phase 4 Dexmedetomidine;Lidocaine;Fentanyl
15 Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT) Completed NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
16 A Comparison Between Right Ventricular Apical Pacing and True Mid-septal Pacing, Verified With Computed Tomography: a Randomized Study Recruiting NCT02412176 Phase 4
17 Randomized Evaluation of Beta Blocker and Angiotensin Converting Enzyme Inhibitor (ACEI) /Angiotensin Receptor Blocker (ARB) Treatment in MINOCA Patients. Recruiting NCT03686696 Phase 4 Beta blocker;ACEI;ARB
18 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Recruiting NCT02347111 Phase 4 Flecainide;Sotalol
19 Beta-blockeRs tO patieNts With CHronIc Obstructive puLmonary diseasE Recruiting NCT03566667 Phase 4 Metoprolol;Standard care
20 Comparison of Intravenous Amiodarone Versus Intravenous Procainamide for the Acute Treatment of Regular and Haemodynamically Well Tolerated Wide QRS Tachycardia (Probably of Ventricular Origen). The PROCAMIO Multicenter Study Terminated NCT00383799 Phase 4 iv Amiodarone;iv Procainamide
21 Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock Terminated NCT02668432 Phase 4 Amiodarone
22 Better Pacing - Biventricular Pacing as Alternative Method in Patients With Disturbances of AV Conduction and Preserved LV Function Withdrawn NCT00559143 Phase 4
23 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
24 An Assessment of the Echo-guided Optimal Cardiac Resynchronization Therapy in Patients Undergoing 'Ablate And Pace' Therapy for Permanent Atrial Fibrillation Completed NCT00111527 Phase 3
25 A Prospective Canadian Multi-Center Randomized Study; Spontaneous AtrioVEntricular Conduction PReservation Completed NCT01219621 Phase 3
26 A Randomized Double-blind Placebo Force-titration Controlled Study With Bisoprolol in Patients With Chronic Heart Failure Secondary to Chagas´ Cardiomyopathy. Completed NCT00323973 Phase 3 Bisoprolol
27 Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem Completed NCT00319982 Phase 2, Phase 3 Diltiazem;Placebo
28 Safety and Efficacy of Dexmedetomidine in Painless Colonoscopy: a Single-center, Randomized, Single-blind Study Not yet recruiting NCT03892928 Phase 3 Dexmedetomidine group
29 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
30 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2
31 Second Study on Cardio-neuromodulation in Humans Unknown status NCT02954666 Phase 2
32 A Randomised Controlled Trial of Combinating an Immune Modulator Fingolimod With Alteplase Bridging With Mechanical Thrombectomy in Acute Ischemic Stroke Unknown status NCT02956200 Phase 2 Fingolimod
33 Ablation of Paroxysmal Atrial Fibrillation Using the Appropriate Contact Force in a Chinese Population: A Prospective Randomized Single-center Trial Unknown status NCT02493075 Phase 1, Phase 2
34 Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery Completed NCT02498769 Phase 1, Phase 2 Botulinum Toxin Type A;Placebo
35 Efficacy of Antihypertensive and Plasma Total Homocysteine Lowering Combined Therapy With Enalapril and Folic Acid in Hypertensive Patients:A Multicenter Double Blind Randomized Clinical Trial Completed NCT00520247 Phase 2 enalapril plus folic acid
36 Combination of Hydroxyurea and Verapamil for Refractory Meningiomas Completed NCT00706810 Phase 2 Hydroxyurea;Verapamil
37 A Phase II, Patient- and Investigator-blinded, Randomized, Placebo-controlled Study to Evaluate Efficacy, Safety and Tolerability of BAF312 (Siponimod) in Patients With Stroke Due to Intracerebral Hemorrhage (ICH) Recruiting NCT03338998 Phase 2 BAF312;Placebo
38 Adjunctive GP Ablation In Redo-PVI: Paroxysmal Atrial Arrhythmias After Pulmonary Vein Isolation Are Driven By Ectopy-Triggering Left Atrial Ganglionated Plexus Recruiting NCT03535818 Phase 2
39 Micra Atrial Tracking Using a Ventricular Accelerometer Study Completed NCT03157297 Phase 1
40 Pharmacokinetics of Orally Administered Dasotraline in Subjects With Mild, Moderate, and Severe Hepatic Dysfunction Completed NCT02795637 Phase 1 dasotraline
41 Prospective Analysis of Low-Dose Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart Completed NCT02462941 Phase 1 Adenosine
42 A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Assess the Safety, Tolerability, and Electrocardiographic Effects of Lofexidine When Administered Orally to Buprenorphine-Maintained Adult Subjects Completed NCT01820442 Phase 1 Lofexidine HCl;Lofexidine-matching sugar pill
43 A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Assess the Safety, Tolerability, and Electrocardiographic Effects of Lofexidine When Administered Orally to Methadone Maintained Adult Subjects Completed NCT01650649 Phase 1 Lofexidine HCl;Lofexidine-matching sugar pill
44 Phase 1 Study of Digoxin for Congenital Polycythemia Due to Up-Regulated Hypoxia Sensing Not yet recruiting NCT03433833 Phase 1 Digoxin
45 Cohort Description of Younger With AV-block Unknown status NCT03024047
46 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
47 Minimizing Right Ventricular Pacing in Dual-chamber Pacemaker Patients With Sinus Node Disease and First Degree Atrioventricular Block. Unknown status NCT01611389
48 Observation of ImageReady™ MR Conditional Pacing System in China Unknown status NCT02636712
49 Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms Unknown status NCT02881671
50 Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block Unknown status NCT01477658

Search NIH Clinical Center for Atrioventricular Block

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Atropine

Cochrane evidence based reviews: atrioventricular block

Genetic Tests for Atrioventricular Block

Genetic tests related to Atrioventricular Block:

# Genetic test Affiliating Genes
1 Atrioventricular Block 29

Anatomical Context for Atrioventricular Block

MalaCards organs/tissues related to Atrioventricular Block:

41
Heart, Testes, Atrioventricular Node, Kidney, Brain, Liver, Lung

Publications for Atrioventricular Block

Articles related to Atrioventricular Block:

(show top 50) (show all 9774)
# Title Authors PMID Year
1
Identification of a new lamin A/C mutation in a Chinese family affected with atrioventricular block as the prominent phenotype. 9 38
20155465 2010
2
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. 9 38
19546853 2009
3
Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. 9 38
19638735 2009
4
Plasma levels of B-type natriuretic peptide in children and adolescents with high degree atrioventricular block. 9 38
18485504 2009
5
A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death. 9 38
19328042 2009
6
Molecular and clinical characterization of a novel SCN5A mutation associated with atrioventricular block and dilated cardiomyopathy. 9 38
19808398 2008
7
Novel point mutation in the NKX2-5 gene in a Moroccan family with atrioventricular conduction disturbance and an atrial septal defect in the oval fossa. 9 38
17184575 2007
8
Effect of right ventricular apex pacing on the Tei index and brain natriuretic peptide in patients with a dual-chamber pacemaker. 9 38
16981923 2006
9
Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter. 9 38
15982494 2005
10
Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect. 9 38
15810002 2005
11
Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies. 9 38
15364612 2004
12
Function follows form: cardiac conduction system defects in Nkx2-5 mutation. 9 38
15368343 2004
13
[Neonatal forms of congenital long QT syndrome]. 9 38
15214551 2004
14
Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations. 9 38
14998624 2004
15
Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects. 9 38
12898247 2003
16
Congenital long QT syndrome and 2:1 atrioventricular block with a mutation of the SCN5A gene. 9 38
12574983 2003
17
Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. 9 38
11897440 2002
18
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. 9 38
11804990 2002
19
Homozygous SCN5A mutation in long-QT syndrome with functional two-to-one atrioventricular block. 9 38
11463728 2001
20
Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. 9 38
10587520 1999
21
[Temporal electric stimulation and right ventricular extension in acute postero-inferior myocardial infarction. Influence on clinical characteristics and prognosis]. 9 38
1807297 1991
22
Mitral Annulus Calcium Score. 38
30636515 2019
23
Predicting postpartum cardiac events in pregnant women with complete atrioventricular block. 38
31060956 2019
24
Comparison of transcatheter versus surgical closure of perimembranous ventricular septal defect in pediatric patients: A systematic review and meta-analysis. 38
31337945 2019
25
[Alcohol septal ablation for obstructive hypertrophic cardiomopathy]. 38
31070317 2019
26
Long-term performance of right ventricular pacing leads: risk factors associated with permanent right ventricular pacing threshold increase. 38
30402790 2019
27
Common Postcardiothoracic Surgery Arrhythmias. 38
31351556 2019
28
Beta-blocker choice and exchangeability in patients with heart failure and chronic obstructive pulmonary disease: an Italian register-based cohort study. 38
31391573 2019
29
Predicting Major Adverse Events in Patients With Acute Myocardial Infarction. 38
31416527 2019
30
Contemporary practice pattern of permanent pacing for conduction disorders in inferior ST-elevation myocardial infarction. 38
31173380 2019
31
Association between PR Interval, First-degree atrioventricular block and major arrhythmic events in patients with Brugada syndrome - Systematic review and meta-analysis. 38
31410227 2019
32
Atrial pacing-induced paroxysmal atrioventricular block: Concealed conduction or phase 3 block or intrahisian reentry? 38
31259426 2019
33
Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block. 38
31410243 2019
34
Interesting case of pre-excitation masking complete atrioventricular block. 38
31187599 2019
35
Reply to Atrial pacing-induced paroxysmal atrioventricular block: Concealed conduction or phase 3 block or intrahisian reentry? 38
31259428 2019
36
Post-pacemaker implant QRS duration and heart failure admission in patients with sick sinus syndrome and complete atrioventricular block. 38
31111655 2019
37
Epigastric Pain, Vomiting, and Cardiac Arrhythmias. 38
31256802 2019
38
A comprehensive scoping review on transvenous temporary pacing therapy. 38
31392624 2019
39
Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG. 38
30928258 2019
40
[A Total Right Heart Bypass Operation for Polysplenia with Unilateral Pulmonary Arteriovenous Fistula;the Usefulness of the Anastomosis of the Hepatic Vein to the Azygous Vein Combined with Dilatable Pulmonary Artery Banding]. 38
31353348 2019
41
Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis. 38
31413232 2019
42
Efficacy and safety of ozanimod in multiple sclerosis: Dose-blinded extension of a randomized phase II study. 38
30043658 2019
43
Comparison of Fast-Track and Conventional Anesthesia for Transthoracic Closure of Ventricular Septal Defects in Pediatric Patients. 38
30867385 2019
44
Transient severe conduction disturbances associated with ankylosing spondylitis. 38
31410244 2019
45
Causes of fetal third-degree atrioventricular block and use of hydroxychloroquine in pregnant women with Ro/La antibodies. 38
30997589 2019
46
Arrhythmias and Adaptations of the Cardiac Conduction System in Former National Football League Players. 38
31337251 2019
47
Cardiac pacing challenge in Sub-Saharan Africa environnement: experience of the Cardiology Department of Teaching Hospital Aristide Le Dantec in Dakar. 38
31412773 2019
48
Increased risk of late pacemaker implantation after ablation for atrioventricular nodal reentry tachycardia: A 10-year follow-up of a nationwide cohort. 38
30826422 2019
49
Initial experience with transcatheter pacemaker implantation for adults with congenital heart disease. 38
31045294 2019
50
Factors predicting persistence of AV nodal block in post-TAVR patients following permanent pacemaker implantation. 38
31429947 2019

Variations for Atrioventricular Block

ClinVar genetic disease variations for Atrioventricular Block:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 SCN5A NM_000335.4(SCN5A): c.4780G> A (p.Asp1594Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 3:38595800-38595800 3:38554309-38554309
2 SCN5A NM_000335.4(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 3:38651267-38651267 3:38609776-38609776

Expression for Atrioventricular Block

Search GEO for disease gene expression data for Atrioventricular Block.

Pathways for Atrioventricular Block

Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 TRPM4 SCN5A MYH7 KCNQ1 KCNE1
2
Show member pathways
12.29 TBX5 SCN5A NKX2-5 KCNQ1 KCNH2 KCNE2
3
Show member pathways
12.25 TBX5 NPPB NKX2-5 MYH7 GATA4
4 12.15 KCNQ1 KCNH2 KCNE2 KCNE1
5 11.92 SCN5A KCNQ1 KCNH2
6
Show member pathways
11.87 KCNQ1 KCNH2 HCN4
7 11.81 TBX5 NKX2-5 GATA4
8
Show member pathways
11.5 SCN5A KCNQ1 KCNE2 KCNE1
9 11.28 TBX5 SCN5A NKX2-5 GATA4
10 11.27 TBX5 NKX2-5 GATA4
11 10.92 SCN5A LMNA KCNQ1 KCNH2 KCNE2 KCNE1
12 10.82 KCNQ1 KCNE1 HCN4
13 10.8 NPPB NKX2-5 MYH7 GATA4
14 10.23 NKX2-5 GATA4

GO Terms for Atrioventricular Block

Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 SCN5A KCNH2 KCNE2 KCNE1 CRYAB
2 Z disc GO:0030018 9.26 SCN5A MYH7 KCNE1 CRYAB
3 voltage-gated potassium channel complex GO:0008076 8.92 KCNQ1 KCNH2 KCNE2 KCNE1

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.93 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
2 potassium ion transport GO:0006813 9.91 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
3 potassium ion transmembrane transport GO:0071805 9.89 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
4 regulation of membrane potential GO:0042391 9.87 TRPM4 KCNH2 HCN4
5 muscle contraction GO:0006936 9.87 MYH7 HCN4 CRYAB
6 cellular response to drug GO:0035690 9.83 KCNQ1 KCNH2 KCNE2
7 cellular response to cAMP GO:0071320 9.81 KCNQ1 KCNE1 HCN4
8 regulation of heart rate GO:0002027 9.77 SCN5A MYH7 HCN4
9 cardiac muscle cell differentiation GO:0055007 9.77 TBX5 NKX2-5 GATA4
10 cardiac muscle contraction GO:0060048 9.77 SCN5A NKX2-5 MYH7 KCNQ1 KCNH2
11 regulation of potassium ion transmembrane transport GO:1901379 9.76 KCNH2 KCNE2 KCNE1
12 cardiac muscle cell action potential involved in contraction GO:0086002 9.75 SCN5A KCNE2 KCNE1
13 positive regulation of potassium ion transmembrane transport GO:1901381 9.74 KCNQ1 KCNH2 KCNE1
14 atrial septum morphogenesis GO:0060413 9.73 TBX5 NKX2-5 GATA4
15 potassium ion export across plasma membrane GO:0097623 9.73 KCNQ1 KCNH2 KCNE2 KCNE1
16 ventricular septum development GO:0003281 9.71 TBX5 GATA4
17 regulation of membrane repolarization GO:0060306 9.71 KCNQ1 KCNH2 KCNE2
18 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.71 KCNQ1 KCNH2 KCNE2 KCNE1
19 positive regulation of heart rate GO:0010460 9.7 TRPM4 KCNQ1
20 regulation of cardiac muscle contraction GO:0055117 9.7 NKX2-5 HCN4
21 cardiovascular system development GO:0072358 9.7 NKX2-5 KCNQ1
22 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.7 KCNQ1 KCNH2 KCNE1
23 positive regulation of sodium ion transport GO:0010765 9.69 SCN5A NKX2-5
24 membrane depolarization during action potential GO:0086010 9.69 SCN5A KCNH2
25 sodium ion import across plasma membrane GO:0098719 9.68 TRPM4 HCN4
26 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.68 KCNE2 KCNE1
27 adult heart development GO:0007512 9.68 NKX2-5 MYH7
28 regulation of cardiac muscle cell contraction GO:0086004 9.68 SCN5A GATA4
29 endocardial cushion development GO:0003197 9.67 TBX5 GATA4
30 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.67 SCN5A HCN4
31 ventricular cardiac muscle cell development GO:0055015 9.66 NKX2-5 LMNA
32 cardiac ventricle morphogenesis GO:0003208 9.66 NKX2-5 GATA4
33 atrial cardiac muscle cell action potential GO:0086014 9.65 SCN5A KCNQ1
34 regulation of delayed rectifier potassium channel activity GO:1902259 9.65 KCNE2 KCNE1
35 positive regulation of cardioblast differentiation GO:0051891 9.65 TBX5 NKX2-5 GATA4
36 SA node cell action potential GO:0086015 9.64 SCN5A HCN4
37 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.64 SCN5A KCNQ1
38 membrane depolarization during SA node cell action potential GO:0086046 9.63 SCN5A HCN4
39 membrane depolarization during AV node cell action potential GO:0086045 9.62 TRPM4 SCN5A
40 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.62 TRPM4 SCN5A
41 membrane repolarization GO:0086009 9.62 KCNQ1 KCNH2 KCNE2 KCNE1
42 membrane depolarization during bundle of His cell action potential GO:0086048 9.61 TRPM4 SCN5A
43 bundle of His development GO:0003166 9.61 TBX5 NKX2-5
44 membrane repolarization during action potential GO:0086011 9.56 KCNQ1 KCNH2 KCNE2 KCNE1
45 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.55 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
46 ventricular cardiac muscle cell action potential GO:0086005 9.35 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
47 regulation of heart rate by cardiac conduction GO:0086091 9.17 TRPM4 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
48 ion transport GO:0006811 10.09 TRPM4 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
49 transmembrane transport GO:0055085 10.06 TRPM4 SCN5A KCNQ1 KCNH2 HCN4

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.78 TRPM4 SCN5A MYH7 KCNQ1
2 voltage-gated ion channel activity GO:0005244 9.77 SCN5A KCNQ1 KCNH2 KCNE2 HCN4
3 ion channel activity GO:0005216 9.76 TRPM4 SCN5A KCNH2 HCN4
4 ion channel binding GO:0044325 9.73 SCN5A KCNQ1 KCNE2 KCNE1
5 scaffold protein binding GO:0097110 9.67 SCN5A KCNQ1 KCNH2
6 delayed rectifier potassium channel activity GO:0005251 9.56 KCNQ1 KCNH2 KCNE2 KCNE1
7 potassium channel activity GO:0005267 9.55 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
8 inward rectifier potassium channel activity GO:0005242 9.52 KCNH2 KCNE2
9 voltage-gated sodium channel activity GO:0005248 9.51 SCN5A HCN4
10 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.5 KCNQ1 KCNH2 KCNE1
11 sodium channel activity GO:0005272 9.4 SCN5A HCN4
12 voltage-gated potassium channel activity GO:0005249 9.35 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
13 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.92 KCNQ1 KCNH2 KCNE2 KCNE1

Sources for Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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