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MCID: ATR057
MIFTS: 54

Atrioventricular Block

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Atrioventricular Block

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MalaCards integrated aliases for Atrioventricular Block:

Name: Atrioventricular Block 12 29 54 6 44 15 71
Av Block 12 15

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0050820
ICD9CM 34 426.10
MeSH 44 D054537
NCIt 50 C26703
SNOMED-CT 67 58547007
ICD10 32 I44.3
UMLS 71 C0004245
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Summaries for Atrioventricular Block

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Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to first-degree atrioventricular block and second-degree atrioventricular block. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. The drugs Verapamil and Hormones have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Atrioventricular block (AV block) is a type of heart block that occurs when the electrical signal... more...

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Related Diseases for Atrioventricular Block

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Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 529)
# Related Disease Score Top Affiliating Genes
1 first-degree atrioventricular block 32.7 TRIM21 SCN5A NPPB MYH7 LMNA KCNH2
2 second-degree atrioventricular block 32.7 TRIM21 SSB SCN5A HCN4
3 progressive familial heart block, type ia 32.4 SCN5A SCN1A GJA5
4 long qt syndrome 14 32.1 SCN5A KCNQ1 KCNH2
5 third-degree atrioventricular block 32.0 TTN TRIM21 SSB SCN5A NPPB KCNH2
6 syncope 31.9 TTN SCN5A KCNQ1 KCNH2
7 myocarditis 31.5 TTN PIK3C2A NPPB
8 inferior myocardial infarction 31.4 PIK3C2A NPPB
9 left bundle branch hemiblock 31.4 SCN5A PIK3C2A NPPB LMNA
10 right bundle branch block 31.3 TRPM4 SCN5A NPPB KCNH2 HCN4
11 progressive familial heart block 31.3 TRPM4 SCN5A NKX2-5 MYH7 KCNQ1 KCNH2
12 heart septal defect 31.3 TBX5 NKX2-5 GJA5 GATA4
13 sick sinus syndrome 31.1 TTN SCN5A LMNA HCN4 GJA5
14 ventricular fibrillation, paroxysmal familial, 1 31.0 SCN5A NKX2-5 KCNQ1 KCNH2 KCNE2 KCNE1
15 ventricular septal defect 31.0 TBX5 NPPB NKX2-5 MYH7 GATA4
16 dextro-looped transposition of the great arteries 30.9 TBX5 NPPB NKX2-5 GATA4
17 familial long qt syndrome 30.9 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
18 mitral valve insufficiency 30.9 TTN TBX5 PIK3C2A NPPB MYH7
19 wolff-parkinson-white syndrome 30.8 SCN5A NPPB NKX2-5 MYH7 KCNQ1
20 myocardial infarction 30.8 SCN5A PIK3C2A NPPB MYH7 KCNQ1 GATA4
21 atrial standstill 1 30.8 TTN SCN5A NPPB MYH7 LMNA GJA5
22 congestive heart failure 30.7 TTN SCN5A PIK3C2A NPPB MYH7 KCNQ1
23 cardiac conduction defect 30.7 TRPM4 SCN5A MYH7 LMNA KCNQ1 KCNH2
24 tricuspid atresia 30.7 TBX5 NKX2-5 GATA4
25 cardiac arrest 30.6 TTN SCN5A PIK3C2A NPPB MYH7 KCNQ1
26 atrial heart septal defect 30.6 TBX5 SCN5A NPPB NKX2-5 MYH7 GJA5
27 sinoatrial node disease 30.6 TBX5 SCN5A NKX2-5 KCNQ1 KCNH2 HCN4
28 cardiac arrhythmia 30.5 SCN5A KCNQ1 KCNH2 KCNE2 HCN4
29 endocardial fibroelastosis 30.5 TRIM21 SSB NPPB MYH7
30 restrictive cardiomyopathy 30.4 TTN TRPM4 NPPB MYH7 LMNA CRYAB
31 muscular dystrophy 30.4 TTN PIK3C2A NKX2-5 MYH7 LMNA CRYAB
32 patent ductus arteriosus 1 30.3 TBX5 NPPB NKX2-5 GATA4
33 long qt syndrome 30.2 TTN TRPM4 SCN5A SCN1A MYH7 LMNA
34 respiratory failure 30.2 TTN PIK3C2A NPPB MYH7 GATA4
35 peripartum cardiomyopathy 30.2 TTN SCN5A MYH7
36 interatrial communication 30.2 TBX5 NKX2-5 GATA4
37 aortic valve disease 2 30.2 TTN TBX5 NPPB NKX2-5 MYH7 GATA4
38 hypoplastic left heart syndrome 30.2 TBX5 NPPB NKX2-5 GJA5 GATA4
39 tetralogy of fallot 30.2 TBX5 SCN5A NPPB NKX2-5 KCNH2 GJA5
40 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 30.1 SCN5A MYH7 KCNQ1 KCNH2
41 double outlet right ventricle 30.1 TBX5 NKX2-5 GJA5 GATA4
42 long qt syndrome 3 30.1 SCN5A SCN1A KCNQ1 KCNH2 KCNE2 KCNE1
43 jervell and lange-nielsen syndrome 1 30.1 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
44 right atrial isomerism 30.1 TBX5 NKX2-5 GJA5
45 cardiomyopathy, familial hypertrophic, 1 30.0 TTN SCN5A MYH7 LMNA KCNH2
46 miyoshi muscular dystrophy 30.0 TTN PIK3C2A MYH7
47 atrioventricular septal defect 29.9 TBX5 NKX2-5 GJA5 GATA4
48 atrial fibrillation 29.9 TTN TBX5 SCN5A NPPB MYH7 LMNA
49 neuromuscular disease 29.9 TTN SCN5A MYH7 LMNA KCNH2 CRYAB
50 long qt syndrome 2 29.7 SCN5A MYH7 KCNQ1 KCNH2 KCNE2 KCNE1

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Aortic Valve Disease 1
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:



Diseases related to Atrioventricular Block
Sources

Symptoms & Phenotypes for Atrioventricular Block

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GenomeRNAi Phenotypes related to Atrioventricular Block according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.72 PIK3C2A
2 Decreased viability GR00055-A-2 9.72 PIK3C2A
3 Decreased viability GR00055-A-3 9.72 PIK3C2A
4 Decreased viability GR00221-A-1 9.72 PIK3C2A
5 Decreased viability GR00221-A-2 9.72 PIK3C2A TTN
6 Decreased viability GR00221-A-4 9.72 PIK3C2A TTN
7 Decreased viability GR00240-S-1 9.72 LMNA PIK3C2A TRIM21
8 Decreased viability GR00249-S 9.72 GJA5 KCNE2 LMNA PIK3C2A TRPM4
9 Decreased viability GR00342-S-1 9.72 PIK3C2A TTN
10 Decreased viability GR00342-S-2 9.72 PIK3C2A
11 Decreased viability GR00342-S-3 9.72 PIK3C2A TTN
12 Decreased viability GR00386-A-1 9.72 LMNA
13 Decreased viability GR00402-S-2 9.72 KCNE2 KCNQ1 SCN5A

MGI Mouse Phenotypes related to Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 GATA4 GJA5 HCN4 KCNH2 KCNQ1 LMNA
2 homeostasis/metabolism MP:0005376 10.1 CRYAB GATA4 GJA5 KCNE2 KCNH2 KCNQ1
3 mortality/aging MP:0010768 10 GATA4 GJA5 HCN4 KCNH2 LMNA MYH7
4 muscle MP:0005369 9.73 CRYAB GATA4 GJA5 HCN4 KCNH2 KCNQ1
5 normal MP:0002873 9.36 GATA4 GJA5 HCN4 KCNQ1 LMNA MYH7
Sources

Drugs & Therapeutics for Atrioventricular Block

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Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 4 52-53-9 2520
2 Hormones Phase 4
3 Vasodilator Agents Phase 4
4 Anti-Arrhythmia Agents Phase 4
5 Calcium, Dietary Phase 4
6 calcium channel blockers Phase 4
7
Calcium Nutraceutical Phase 4 7440-70-2 271
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10 Gastrointestinal Agents Phase 3
11 Anti-Inflammatory Agents Phase 3
12 Hormone Antagonists Phase 3
13 glucocorticoids Phase 3
14 Antineoplastic Agents, Hormonal Phase 3
15 Antiemetics Phase 3
16
Adenosine Approved, Investigational Phase 1 58-61-7 60961
17
Calcium carbonate Approved, Investigational Phase 1 471-34-1
18 Neurotransmitter Agents Phase 1
19 Analgesics Phase 1
20
Acetylcholine Approved, Investigational 51-84-3 187
21
Nimodipine Approved, Investigational 66085-59-4 4497
22
Midazolam Approved, Illicit 59467-70-8 4192
23
Thrombin Approved, Investigational
24 Antihypertensive Agents
25 Immunoglobulins
26 Antibodies
27 Antibodies, Antinuclear
28 Hemostatics
29 Coagulants
30 Pharmaceutical Solutions

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 IntAct, Study on Promotion of Intrinsic Activity. Unknown status NCT00156741 Phase 4
2 A Randomized, Prospective Multicenter Pilot Study to Determine the Influence of the Ventricular Pacing Site on the Incidence of Atrial Fibrillation and Heart Failure in Patients With Indication for Permanent Pacemaker Stimulation Therapy. Unknown status NCT00292383 Phase 4
3 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
4 Randomized Clinical Study to Assess the Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
5 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
6 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
7 Atrioventricular Block and Cluster Headache Not yet recruiting NCT04406259 Phase 4 Verapamil
8 Better Pacing - Biventricular Pacing as Alternative Method in Patients With Disturbances of AV Conduction and Preserved LV Function Withdrawn NCT00559143 Phase 4
9 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
10 Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ) Recruiting NCT04474223 Phase 3 Dexamethasone;IVIG
11 Prospective Analysis of Low-Dose Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart Completed NCT02462941 Phase 1 Adenosine
12 Micra Atrial Tracking Using a Ventricular Accelerometer Study Completed NCT03157297 Phase 1
13 Effect of Atrioventricular Optimization on Left Ventricular Function With Dual Chamber Pacemaker; Prospective Randomized Trial Unknown status NCT03556189
14 Cohort Description of Younger With AV-block Unknown status NCT03024047
15 Impact of Left Ventricular Pacing on Left Ventricular Systolic Function in High-risk Bradycardia Patients Unknown status NCT01302717
16 BiventRicular Pacing in prolongEd Atrio-Ventricular intervaL: the REAL-CRT Study Unknown status NCT02150538
17 Impact of Right Ventricular Pacing Determined by Electrocardiography; Prospective Randomized Trial Unknown status NCT01922518
18 Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block Unknown status NCT01477658
19 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
20 Minimizing Right Ventricular Pacing in Dual-chamber Pacemaker Patients With Sinus Node Disease and First Degree Atrioventricular Block. Unknown status NCT01611389
21 Multi-center, Randomized, Controlled Trial to Compare Feasibility, Safety and Efficacy of Zero-Fluoroscopic Navigation With Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Unknown status NCT03118440
22 Multi-center, Randomized, Controlled Trial to Compare Feasibility, Safety and Efficacy of Zero-Fluoroscopic Navigation With Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation Unknown status NCT03118427
23 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level in Hypertensive Patients Treated With Blood Pressure Lowering Drugs Completed NCT01882790
24 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level Completed NCT01877993
25 CHOosing the rIght paCing Mode in Heart failurE : Should Heart Failure Patients With Bradycardia Receive Biventricular Pacemakers Rather Than Conventional Pacemakers? Completed NCT00875732
26 Optimal Pacing in Patients With First-degree AV-block Completed NCT01985802
27 Prevention of Syncope by Cardiac Pacing in Patients With Bifascicular Block Completed NCT01463358
28 Corrected QT Interval in Patients With Pacemaker Dependency (QT-TENDENCY-Study) Completed NCT01694550
29 Biventricular Versus Right Ventricular Pacing in Heart Failure Patients With Atrioventricular Block (BLOCK HF) Completed NCT00267098
30 Biventricular Pacing for Atrioventricular Block in Left Ventricular Dysfunction to Prevent Cardiac Desynchronization Completed NCT00187278
31 Evolution of the PR Interval in Patients Implanted With a Dual Chamber Pacemaker With Algorithm for Spontaneous AV Conduction Preservation Completed NCT02586480
32 Repolarization Disorders and Heart Conduction Disorders in Patients With Systemic Lupus Erythematous Completed NCT02162992
33 Observation of ImageReadyâ„¢ MR Conditional Pacing System in China Completed NCT02636712
34 The Atrial High Rate Episodes (A-HIRATE) in Pacemaker Patients Completed NCT00627328
35 Registry on Automatic Algorhitm on Atrial Capture: REAL ACap Registry Completed NCT02400983
36 Clinical Evaluation of Safety and Performance of the BackBeat Moderato System Completed NCT02282033
37 Micra Atrial TRacking Using A Ventricular AccELerometer 2 Completed NCT03752151
38 Influence of Atrial Pulse Width in the Behaviour of ACapâ„¢ Confirm Algorithm. Completed NCT00832260
39 Pacemaker Utilization and Ventricular Pacing in Patients Undergoing Trans-catheter Aortic Valve Replacement (TAVR) Completed NCT02994667
40 Impact of Pacing Mode and Diastolic Function on Cardiac Output Completed NCT04068233
41 Exploring Arrhythmias After Hospital Discharge in Post-Myocardial Infarction Patients - the MADDEC Project Completed NCT03231826
42 Junctional AV Ablation in CRT-D Patients With Atrial Fibrillation (JAVA-CRT Trial) Completed NCT02946853
43 Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following Transcatheter Aortic Valve Replacement. The PROMOTE Study Recruiting NCT04139616
44 Accelerometer Sensing for Micra AV Study Recruiting NCT04245345
45 Pacing-induced Cardiomyopathy - the Importance of Right Ventricular Pacing Site and Patterns of Dyssynchronous Myocardial Activation Recruiting NCT04269733
46 Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block: Possible Predictors for High-grade AV Block Following Transcatheter Aortic Valve Replacement Recruiting NCT04128384
47 Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI) Recruiting NCT03303612
48 Registry of His Bundle, Bachmann Bundle and Left Bundle Branch Area Pacing for Various Pacing Indications Recruiting NCT04749836
49 Impact of Atrio-ventricular Optimization With His Bundle Pacing on Treatment of Atrio-ventricular Dromotropathy Recruiting NCT04544345
50 Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block): A Randomized Controlled Trial Recruiting NCT04730921

Search NIH Clinical Center for Atrioventricular Block

Cochrane evidence based reviews: atrioventricular block

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Genetic Tests for Atrioventricular Block

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Genetic tests related to Atrioventricular Block:

# Genetic test Affiliating Genes
1 Atrioventricular Block 29
Sources

Anatomical Context for Atrioventricular Block

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MalaCards organs/tissues related to Atrioventricular Block:

40
Heart, Atrioventricular Node, Brain, Kidney, Thyroid, Breast, Endothelial
Sources

Publications for Atrioventricular Block

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Articles related to Atrioventricular Block:

(show top 50) (show all 10432)
# Title Authors PMID Year
1
Identification of a new lamin A/C mutation in a Chinese family affected with atrioventricular block as the prominent phenotype. 54 61
20155465 2010
2
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. 54 61
19546853 2009
3
Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. 61 54
19638735 2009
4
Plasma levels of B-type natriuretic peptide in children and adolescents with high degree atrioventricular block. 54 61
18485504 2009
5
A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death. 54 61
19328042 2009
6
Molecular and clinical characterization of a novel SCN5A mutation associated with atrioventricular block and dilated cardiomyopathy. 61 54
19808398 2008
7
Novel point mutation in the NKX2-5 gene in a Moroccan family with atrioventricular conduction disturbance and an atrial septal defect in the oval fossa. 54 61
17184575 2007
8
Effect of right ventricular apex pacing on the Tei index and brain natriuretic peptide in patients with a dual-chamber pacemaker. 61 54
16981923 2006
9
Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter. 54 61
15982494 2005
10
Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect. 54 61
15810002 2005
11
Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies. 61 54
15364612 2004
12
Function follows form: cardiac conduction system defects in Nkx2-5 mutation. 54 61
15368343 2004
13
[Neonatal forms of congenital long QT syndrome]. 61 54
15214551 2004
14
Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations. 61 54
14998624 2004
15
Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects. 54 61
12898247 2003
16
Congenital long QT syndrome and 2:1 atrioventricular block with a mutation of the SCN5A gene. 61 54
12574983 2003
17
Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. 61 54
11897440 2002
18
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. 54 61
11804990 2002
19
Homozygous SCN5A mutation in long-QT syndrome with functional two-to-one atrioventricular block. 61 54
11463728 2001
20
Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. 54 61
10587520 1999
21
[Temporal electric stimulation and right ventricular extension in acute postero-inferior myocardial infarction. Influence on clinical characteristics and prognosis]. 54 61
1807297 1991
22
Epicardial adipose tissue predicted prolonged QTc interval in patients with arterial hypertension. 61
33183070 2021
23
Early Versus Delayed Pacemaker for Heart Block After Valve Surgery: A Cost-Effectiveness Analysis. 61
33279841 2021
24
Dual-chamber pacing using a hybrid transvenous and leadless pacing approach. 61
33559285 2021
25
Delayed radiofrequency ablation efficacy in slow pathway ablation: a case report. 61
33569524 2021
26
The indications and safety of prolonged temporary pacing using active-fixation leads and externalized pulse generator. 61
33538060 2021
27
Screening for ATTR amyloidosis in the clinic: overlapping disorders, misdiagnosis, and multiorgan awareness. 61
33609196 2021
28
Macrophage activation syndrome in a newborn: report of a case associated with neonatal lupus erythematosus and a summary of the literature. 61
33568193 2021
29
Transient complete atrioventricular block and ST-segment elevation induced by coronary vasospasm due to iatrogenic hyperkalemia: a case report. 61
33568154 2021
30
Heart Failure, Atrioventricular Block, and Ventricular Tachycardia in Sarcoidosis. 61
33599141 2021
31
A case with recovery from high degree atrioventricular-block with steroid therapy in cardiac sarcoidosis with AH block: a possible new sign of responder? 61
33520031 2021
32
The ECG in sarcoidosis - a marker of cardiac involvement? Current evidence and clinical implications. 61
32917454 2021
33
Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish. 61
33549680 2021
34
Selective His Bundle Pacing in a Patient With Ebstein's Anomaly and Atrioventricular Block. 61
33602413 2021
35
Long-term outcomes in young patients with atrioventricular block of unknown aetiology. 61
33599276 2021
36
Second-Degree Atrioventricular Block-Reply. 61
33555309 2021
37
Second-degree Atrioventricular Block. 61
33555298 2021
38
Non-pledget commissural suture technique to avoid atrioventricular block. 61
33608837 2021
39
First-degree atrioventricular block is significantly associated with incident atrial fibrillation in the population predominantly including participants aged ≥ 60 years. 61
33595701 2021
40
Complete atrioventricular block with ventricular pacing mimics pulsus paradoxus. 61
33538847 2021
41
Arrhythmic burden in patients with new-onset persistent left bundle branch block after transcatheter aortic valve replacement: 2-year results of the MARE study. 61
33083813 2021
42
Differentiating hereditary arrhythmogenic right ventricular cardiomyopathy from cardiac sarcoidosis fulfilling 2010 ARVC Task Force Criteria. 61
32976989 2021
43
Ventricular Tachycardia in a Patient With Dilated Cardiomyopathy Caused by a Novel Mutation of Lamin A/C Gene: Insights From Features on Electroanatomic Mapping, Catheter Ablation and Tissue Pathology. 61
33032896 2021
44
Cardiac conduction abnormalities in patients with degenerated bioprostheses undergoing transcatheter aortic valve-in-valve implantations and their impact on long-term outcomes. 61
33592238 2021
45
Effect of a restrictive pacemaker implantation strategy on mortality after transcatheter aortic valve implantation. 61
33372688 2021
46
Predictors of permanent pacemaker implantation after ACURATE neo transcatheter heart valve implantation. 61
33373045 2021
47
Modified annular suturing technique for minimizing postoperative pacemaker use after surgical aortic valve replacement. 61
32725475 2021
48
Tricuspid valve annuloplasty and mitral valve replacement are associated with bradyarrhythmia after mitral valve surgery. 61
33566390 2021
49
Permanent His bundle pacing using a new tridimensional delivery sheath and a standard active fixation pacing lead: The telescopic technique. 61
33410557 2021
50
Beyond the Basics: A Sampling of Puzzling Dysrhythmias. 61
33560434 2021
Sources

Variations for Atrioventricular Block

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ClinVar genetic disease variations for Atrioventricular Block:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 SCN5A NM_198056.2(SCN5A):c.4783G>A (p.Asp1595Asn) SNV not provided 9385 rs137854607 3:38595800-38595800 3:38554309-38554309
2 SCN5A NM_000335.5(SCN5A):c.892G>A (p.Gly298Ser) SNV not provided 9387 rs137854608 3:38651267-38651267 3:38609776-38609776
Sources

Expression for Atrioventricular Block

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Search GEO for disease gene expression data for Atrioventricular Block.
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Pathways for Atrioventricular Block

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Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Cardiac conduction 65
Show member pathways
 12.38 TTN TBX5 SCN5A SCN1A NKX2-5 KCNQ1
2
cGMP-PKG signaling pathway 36
Show member pathways
 12.35 SCN5A NPPB MYH7 KCNQ1 KCNE1 GATA4
3
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.27 TBX5 NPPB NKX2-5 MYH7 GATA4
4
Dopamine-DARPP32 Feedback onto cAMP Pathway 63
12.15 KCNQ1 KCNH2 KCNE2 KCNE1
5
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.66 TBX5 NKX2-5 GATA4
6
Phase 0 - rapid depolarisation 65
Show member pathways
 11.53 SCN5A SCN1A KCNQ1 KCNE2 KCNE1
7
Cardiac Progenitor Differentiation 1
11.35 TBX5 SCN5A NKX2-5 GATA4
8
Heart Development 1
11.3 TBX5 NKX2-5 GATA4
9
Antiarrhythmic Pathway, Pharmacodynamics 60
10.97 SCN5A LMNA KCNQ1 KCNH2 KCNE2 KCNE1
10
TarBasePathway 1
10.86 KCNQ1 KCNE1 HCN4
11
Cardiomyocyte Differentiation through BMP Receptors 63
10.8 NPPB NKX2-5 MYH7 GATA4
12
HOP Signaling 63
10.26 NKX2-5 GATA4
Sources

GO Terms for Atrioventricular Block

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Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.77 SCN5A KCNH2 KCNE2 KCNE1 CRYAB
2 intercalated disc GO:0014704 9.33 SCN5A SCN1A GJA5
3 voltage-gated sodium channel complex GO:0001518 9.32 SCN5A SCN1A
4 sodium channel complex GO:0034706 9.26 TRPM4 SCN1A
5 voltage-gated potassium channel complex GO:0008076 9.26 KCNQ1 KCNH2 KCNE2 KCNE1
6 Z disc GO:0030018 9.1 TTN SCN5A SCN1A MYH7 KCNE1 CRYAB

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.15 TRPM4 SCN5A SCN1A KCNQ1 KCNH2 HCN4
2 ion transport GO:0006811 10.14 TRPM4 SCN5A SCN1A KCNQ1 KCNH2 KCNE2
3 ion transmembrane transport GO:0034220 10.02 TRPM4 SCN5A SCN1A KCNH2
4 potassium ion transport GO:0006813 9.99 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4 GJA5
5 potassium ion transmembrane transport GO:0071805 9.96 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
6 regulation of membrane potential GO:0042391 9.93 TRPM4 SCN1A KCNH2 HCN4
7 muscle contraction GO:0006936 9.93 TTN MYH7 HCN4 CRYAB
8 regulation of ion transmembrane transport GO:0034765 9.91 SCN5A SCN1A KCNQ1 KCNH2 KCNE2 KCNE1
9 sodium ion transmembrane transport GO:0035725 9.89 SCN5A SCN1A HCN4
10 cation transmembrane transport GO:0098655 9.87 TRPM4 SCN5A SCN1A
11 cellular response to drug GO:0035690 9.86 KCNQ1 KCNH2 KCNE2
12 cellular response to cAMP GO:0071320 9.85 KCNQ1 KCNE1 HCN4
13 potassium ion import across plasma membrane GO:1990573 9.83 KCNH2 KCNE2 HCN4
14 ventricular septum development GO:0003281 9.83 TBX5 GJA5 GATA4
15 regulation of heart rate GO:0002027 9.81 SCN5A MYH7 HCN4
16 regulation of cardiac muscle contraction GO:0055117 9.8 NKX2-5 HCN4 GJA5
17 cardiac muscle cell action potential involved in contraction GO:0086002 9.8 SCN5A SCN1A KCNE2 KCNE1
18 cardiac muscle cell differentiation GO:0055007 9.79 TBX5 NKX2-5 GATA4
19 regulation of potassium ion transmembrane transport GO:1901379 9.79 KCNH2 KCNE2 KCNE1
20 potassium ion export across plasma membrane GO:0097623 9.78 KCNQ1 KCNH2 KCNE2 KCNE1
21 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.77 KCNQ1 KCNE2 KCNE1
22 membrane depolarization during action potential GO:0086010 9.77 SCN5A SCN1A KCNH2
23 positive regulation of potassium ion transmembrane transport GO:1901381 9.76 KCNQ1 KCNH2 KCNE1
24 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.76 KCNQ1 KCNH2 KCNE2 KCNE1
25 atrial septum morphogenesis GO:0060413 9.75 TBX5 NKX2-5 GATA4
26 regulation of membrane repolarization GO:0060306 9.74 KCNQ1 KCNH2 KCNE2
27 membrane repolarization GO:0086009 9.73 KCNQ1 KCNH2 KCNE2 KCNE1
28 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.72 KCNQ1 KCNH2 KCNE1
29 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.72 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1
30 positive regulation of sodium ion transport GO:0010765 9.71 SCN5A NKX2-5
31 striated muscle contraction GO:0006941 9.71 TTN MYH7
32 regulation of cardiac muscle cell contraction GO:0086004 9.71 SCN5A GATA4
33 adult heart development GO:0007512 9.71 NKX2-5 MYH7
34 membrane repolarization during action potential GO:0086011 9.71 KCNQ1 KCNH2 KCNE2 KCNE1
35 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.7 SCN5A HCN4
36 cardiac muscle tissue morphogenesis GO:0055008 9.7 TTN NKX2-5
37 endocardial cushion development GO:0003197 9.7 TBX5 GATA4
38 positive regulation of cardioblast differentiation GO:0051891 9.7 TBX5 NKX2-5 GATA4
39 atrial cardiac muscle cell action potential GO:0086014 9.69 SCN5A KCNQ1
40 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.69 SCN5A GJA5
41 ventricular cardiac muscle cell development GO:0055015 9.69 NKX2-5 LMNA
42 atrial septum development GO:0003283 9.68 TBX5 GJA5
43 regulation of delayed rectifier potassium channel activity GO:1902259 9.68 KCNE2 KCNE1
44 negative regulation of voltage-gated potassium channel activity GO:1903817 9.67 KCNQ1 KCNE2
45 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.67 SCN5A KCNQ1
46 membrane depolarization during SA node cell action potential GO:0086046 9.67 SCN5A HCN4
47 membrane depolarization during AV node cell action potential GO:0086045 9.66 TRPM4 SCN5A
48 SA node cell action potential GO:0086015 9.66 SCN5A HCN4
49 membrane depolarization during bundle of His cell action potential GO:0086048 9.65 TRPM4 SCN5A
50 ventricular cardiac muscle cell action potential GO:0086005 9.65 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 10.15 TTN TRPM4 TRIM21 LMNA KCNH2 KCNE2
2 calmodulin binding GO:0005516 9.83 TTN TRPM4 SCN5A MYH7 KCNQ1
3 ion channel binding GO:0044325 9.8 SCN5A KCNQ1 KCNE2 KCNE1
4 ion channel activity GO:0005216 9.73 TRPM4 SCN5A SCN1A KCNQ1 KCNH2 HCN4
5 potassium channel activity GO:0005267 9.72 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
6 scaffold protein binding GO:0097110 9.7 SCN5A KCNQ1 KCNH2
7 cation channel activity GO:0005261 9.69 TRPM4 SCN5A SCN1A
8 delayed rectifier potassium channel activity GO:0005251 9.67 KCNQ1 KCNH2 KCNE2 KCNE1
9 sodium channel activity GO:0005272 9.65 SCN5A SCN1A HCN4
10 voltage-gated sodium channel activity GO:0005248 9.63 SCN5A SCN1A HCN4
11 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.58 KCNQ1 KCNH2 KCNE1
12 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216 9.56 NKX2-5 GATA4
13 voltage-gated potassium channel activity GO:0005249 9.55 KCNQ1 KCNH2 KCNE2 KCNE1 HCN4
14 telethonin binding GO:0031433 9.54 TTN KCNE1
15 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.26 KCNQ1 KCNH2 KCNE2 KCNE1
16 voltage-gated ion channel activity GO:0005244 9.17 SCN5A SCN1A KCNQ1 KCNH2 KCNE2 KCNE1
Sources

Sources for Atrioventricular Block

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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