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MCID: ATR005
MIFTS: 50

Atrophic Gastritis

Categories: Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Atrophic Gastritis

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MalaCards integrated aliases for Atrophic Gastritis:

Name: Atrophic Gastritis 12 15 17
Gastritis, Atrophic 44 71
Gastritis Atrophic 54
Gastric Atrophy 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8929
ICD9CM 34 535.1
MeSH 44 D005757
NCIt 50 C7405
SNOMED-CT 67 155713006
ICD10 32 K29.4
UMLS 71 C0017154
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Summaries for Atrophic Gastritis

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MalaCards based summary : Atrophic Gastritis, also known as gastritis, atrophic, is related to autoimmune atrophic gastritis and helicobacter pylori infection, and has symptoms including dyspepsia An important gene associated with Atrophic Gastritis is GAST (Gastrin), and among its related pathways/superpathways are Shigellosis and IL-17 Family Signaling Pathways. The drugs Amphotericin B and Methylcobalamin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, spleen and endothelial, and related phenotype is neoplasm.

Wikipedia : 74 Atrophic gastritis is a process of chronic inflammation of the gastric mucosa of the stomach, leading to... more...

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Related Diseases for Atrophic Gastritis

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Diseases in the Atrophic Gastritis family:

Autoimmune Atrophic Gastritis

Diseases related to Atrophic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 556)
# Related Disease Score Top Affiliating Genes
1 autoimmune atrophic gastritis 33.1 GAST CHGA
2 helicobacter pylori infection 31.9 TNF IL1RN IL1B IL10 CXCL8
3 gastric adenocarcinoma 31.3 TP53 S100A8 GAST CDX2
4 autoimmune gastritis 31.3 TNF IL1B IL10 GAST
5 duodenal ulcer 31.1 TNF S100A8 IL1RN IL1B IL10 GAST
6 thyroiditis 31.0 TNF IL1B IL10
7 gastric ulcer 31.0 TP53 TNF S100A8 IL1RN IL1B GAST
8 esophagitis 30.9 TP53 TNF IL1B IL10 GAST CXCL8
9 diarrhea 30.8 TNF IL1B IL10 GAST CXCL8
10 peptic esophagitis 30.8 TNF S100A8 IL1B GAST CXCL8 CDX2
11 autoimmune disease 30.8 TNF IL1RN IL1B IL10 CXCL8
12 purpura 30.8 TNF IL1B IL10
13 type 1 diabetes mellitus 30.7 TNF IL1RN IL1B IL10 CXCL8
14 peptic ulcer disease 30.7 TP53 TNF S100A8 IL1RN IL1B IL10
15 dermatitis herpetiformis 30.7 TNF IL10 CXCL8
16 epstein-barr virus-associated gastric carcinoma 30.6 TNF MUC6 IL10
17 stomatitis 30.6 TNF IL1B IL10 CXCL8
18 duodenal gastrinoma 30.6 GAST CHGA
19 gastric neuroendocrine neoplasm 30.6 GAST CHGA
20 gastric gastrinoma 30.5 GAST CHGA
21 adenoma 30.5 TP53 ODC1 MUC6 CHGA CDX2
22 pharyngitis 30.5 TNF IL1B CXCL8
23 celiac disease 1 30.5 TNF IL1B IL10 GHRL GAST CXCL8
24 microinvasive gastric cancer 30.5 TP53 TFF2 S100A8 MUC6 GAST CDX2
25 pyoderma 30.5 TNF IL1B CXCL8
26 bile reflux 30.4 S100A8 GAST CDX2
27 erythema nodosum 30.4 TNF IL1B IL10 CXCL8
28 colorectal adenoma 30.4 TP53 ODC1 ERCC6 CXCL8
29 disease by infectious agent 30.3 TNF IL1RN IL1B IL10
30 periodontitis 30.3 TNF IL1RN IL1B IL10 CXCL8
31 adult respiratory distress syndrome 30.3 TNF IL1RN IL1B IL10 CXCL8
32 bone resorption disease 30.2 TNF IL1B ERCC6
33 lichen planus 30.2 TP53 TNF IL1B IL10 CXCL8
34 gastric cancer 30.2 TP53 TFF2 S100A8 PGA5 PGA4 PGA3
35 cholecystitis 30.1 TP53 S100A8 MUC6
36 alcohol dependence 30.0 TNF IL1RN IL1B GHRL ADH7
37 colitis 30.0 TNF TFF2 IL1RN IL1B IL10 CXCL8
38 gastritis 30.0 TP53 TNF TFF2 S100A8 PGC PGA5
39 gastroesophageal reflux 30.0 TP53 TNF S100A8 PGC PGA3 IL1RN
40 peripheral nervous system disease 30.0 TP53 TNF IL1B IL10 ERCC6 CXCL8
41 osteoporosis 29.7 TP53 TNF IL1RN IL1B IL10 GHRL
42 barrett esophagus 29.7 TP53 TFF2 S100A8 ODC1 MUC6 GAST
43 diabetes mellitus 29.6 TP53 TNF IL1RN IL1B IL10 GHRL
44 pernicious anemia 11.3
45 vitamin b12 deficiency 10.6
46 deficiency anemia 10.6
47 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.5
48 iron metabolism disease 10.5
49 physiological polycythemia 10.5 TNF IL1B
50 punctate inner choroidopathy 10.5 TNF IL10

Comorbidity relations with Atrophic Gastritis via Phenotypic Disease Network (PDN): (show all 16)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Anxiety
Bronchitis Deficiency Anemia
Duodenitis Dysthymic Disorder
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Iron Deficiency Anemia Irritable Bowel Syndrome
Paralytic Ileus Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Atrophic Gastritis:



Diseases related to Atrophic Gastritis
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Symptoms & Phenotypes for Atrophic Gastritis

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UMLS symptoms related to Atrophic Gastritis:


dyspepsia

MGI Mouse Phenotypes related to Atrophic Gastritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 CDX2 ERCC6 GAST IL10 IL1B TNF
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Drugs & Therapeutics for Atrophic Gastritis

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Drugs for Atrophic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
2
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
3
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
4
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
5
Clarithromycin Approved Phase 4 81103-11-9 84029
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
7
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
8
Cobalamin Experimental Phase 4 13408-78-1 6857388
9 Vitamins Phase 4
10 Vitamin B Complex Phase 4
11 Vitamin B 12 Phase 4
12 Vitamin B12 Phase 4
13 Liposomal amphotericin B Phase 4
14 Antacids Phase 4
15 Anti-Ulcer Agents Phase 4
16 Gastrointestinal Agents Phase 4
17 Proton Pump Inhibitors Phase 4
18
Rebamipide Approved, Investigational Phase 3 90098-04-7
19 Anti-Inflammatory Agents Phase 3
20 Protective Agents Phase 3
21 Antioxidants Phase 3
22
Ethanol Approved Phase 2 64-17-5 702
23
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
24
Turmeric Approved, Experimental, Investigational Phase 2
25
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
26
Cysteine Approved, Nutraceutical Phase 2 52-90-4 5862
27 Analgesics, Non-Narcotic Phase 2
28 Anti-Inflammatory Agents, Non-Steroidal Phase 2
29 Antirheumatic Agents Phase 2
30 Analgesics Phase 2
31 Turmeric extract Phase 2
32 Ginger Approved
33 Hydrotalcite Approved, Experimental, Investigational 12304-65-3
34 Trace Elements Early Phase 1
35 Nutrients Early Phase 1
36 Micronutrients Early Phase 1
37 Immunoglobulins
38 Antibodies
39 Hormone Antagonists
40 Hormones
41 Gastrins
42 Astragalus
43 Chinese Salvia
44 Skullcap
45 Liver Extracts

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 A Phase IV Study to Evaluate the Efficacy and Safety of Vitamin B12 Contains Extract of Lamb's Stomach in Treatment of Chronic Atrophic Gastritis Completed NCT01474044 Phase 4 Gastropylor Complex Capsules
2 A Multicenter, Randomized, Open-label Phase IV Study Exploring Symptom Control Rate in Co-diagnosed NERD and Chronic Gastritis Patients Treated With 8 Weeks Esomeprazole Treatment Regimen and 2 Weeks Esomeprazole Treatment Regimen Completed NCT01119768 Phase 4 Esomeprazole;Esomeprazole
3 Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality Recruiting NCT02047994 Phase 4 Triple therapy
4 Anti Free Radical & Anti Inflammatory Effect & Safety of Rebamipide in Chronic Gastritis Completed NCT00996788 Phase 3 Rebamipide
5 A Multi-Center, Double-blind, Randomized, Placebo-controlled, Parallel-Group, Phase 3, Therapeutic Confirmatory Clinical Trial to Evaluate the Efficacy and Safety of DWP14012 in Patients With Acute or Chronic Gastritis Enrolling by invitation NCT04341454 Phase 3 DWP14012 X mg;DWP14012 X mg placebo;DWP14012 Y mg;DWP14012 Y mg placebo
6 Slow-release L-cysteine Capsule Prevents Carcinogenic Gastric Acetaldehyde Exposure in Helicobacter-associated Atrophic Gastritis Completed NCT02524262 Phase 2
7 A Single Centre, Pilot Trial of YF476 in Patients With Chronic Atrophic Gastritis, Hypergastrinaemia and Type I Gastric Carcinoids Completed NCT01339169 Phase 2 YF476
8 Randomized, Double-Blind, Placebo-Controlled Trial of Meriva® (Curcuminoids) as a Candidate Chemoprevention Agent for Gastric Carcinogenesis Active, not recruiting NCT02782949 Phase 2 Curcumin
9 Randomized, Double-Blind, Placebo-Controlled, Non-inferiority Clinical Trial on the Efficacy and Safety of Houtou Jianweiling Tablet in the Treatment of Chronic Non-Atrophic Gastritis Not yet recruiting NCT04672018 Phase 2
10 A Single Centre, Pilot Trial of YF476 in Patients With Chronic Atrophic Gastritis, Hypergastrinaemia and Type I Gastric Carcinoids Terminated NCT01444014 Phase 2 YF476
11 Randomized Clinical Trial: Weifuchun Treatment on Precancerous Lesions of Gastric Cancer Unknown status NCT03814629 Early Phase 1 Weifuchun
12 Value of Additional Corpus Biopsy for Diagnosis of H Pylori in Atrophic Gastritis. Prospective Non-randomized Multicenter Study Unknown status NCT02675010
13 Gastropanel *for Early Detection of Gastric Atrophy and Gastric Cancer Risk Unknown status NCT02114411
14 System Biology Research of Spleen Qi Deficiency Associated "Qi Deficiency Constitution-Disease" Unknown status NCT02915393
15 A Prospective Cohort Study of Early Detection and Screening Strategy for Gatric Cancer in Sichuan Province China (SIGES-01) Unknown status NCT03597672
16 Difference of Gastric Microbiota in the Process of Correa's Model. Unknown status NCT02833363
17 A Prospective Cohort Study for Development of Korean Gastric Cancer Prediction Model and Tailored Gastric Cancer Screening Program Unknown status NCT02457624
18 High-Definition White Light Endoscopy vs Optical Enhancement With High Definition Optical Magnification in the Diagnosis of Gastritis, H. Pylori Infection and Atrophic Gastritis in Dyspeptic Patients: A Randomized Controlled Trial. Completed NCT04296513
19 Grading Atrophic Gastritis by a New Quantitative Method Using Confocal Laser Endomicroscopy Probe (p-CLE): First Results of a Prospective Cohort Study Completed NCT02351154
20 Significance of Helicobacter Pylori Infection and Pepsinogen Levels on the Prognosis of Atrophic Gastritis - Observational Study Completed NCT01824953
21 Optical Enhancement System â„¢ Plus Optical Magnification Utility in the Identification of Normal Gastric Mucosa, Helicobacter Pylori Associated Gastritis, and Gastric Atrophy Completed NCT02597517
22 Linked Color Imaging (LCI) System in the Identification of Normal Gastric Mucosa, Helicobacter Pylori Associated Gastritis and Gastric Atrophy Completed NCT02724280
23 Evaluation of a Health Food Supplement Containing Anti-Helicobacter Pylori Urease IgY Antibody on Patients With Chronic Gastritis in Hanoi, Vietnam Completed NCT02721355
24 New Classification of Gastric Pit Patterns and Vessel Architecture Using Probe-based Confocal Laser Endomicroscopy Completed NCT01896310
25 Volatile Marker Testing for Digestive Cancer and Precancerous Lesion Detection, Evaluation of Confounding Factors Completed NCT02332213
26 OLGA Stage is More Appropriate in Predicting Early Gastric Cancer Than Endoscopic Gastric Atrophy Classification and OLGIM Stage: A Prospective Study Completed NCT02562976
27 Study of the Chinese Prescription Weiqi Decoction on Chronic Atrophic Gastritis Completed NCT00920712 Weiqi decotion
28 Surveillance Strategies of Patients With Precancerous Conditions and Lesions in the Stomach Recruiting NCT03250091
29 SUrveillance of PREMalignant Stomach - Individualized Endoscopic Follow-up Recruiting NCT04613570
30 Effect of Helicobacter Pylori Eradication on the Reversibility of Atrophic Gastritis and Intestinal Metaplasia in Korean Patients. Recruiting NCT02691637
31 Performance of Endoscopic and Histological Criteria of Atrophic Gastritis and Intestinal Metaplasia in Predicting Risk of Gastric Cancer - a Multicenter Case Control Study Recruiting NCT04184960
32 Usefulness of Serum Pepsinogen and Gastrin as the Predictive Biomarker of Atrophic Gastritis, Intestinal Metaplasia and Gastric Cancer in Korea Recruiting NCT02184910 pepsinogen and gastrin
33 Validating Features of Traditional Chinese Syndrome Patterns for Chronic Atrophic Gastritis Malignant Transformation: A Cross-sectional Study Recruiting NCT03314038
34 Risk Assessment and Syndrome Evolution Models Combining Traditional Chinese Medicine and Modern Medicine Indicators for Chronic Atrophic Gastritis Malignant Transformation: a Registry Study Recruiting NCT03261934
35 The Evaluation of OLGA and OLGIM Stage Systems for Prediction of Gastric Cancer Risk and Interaction With Other Risk Factors According to Lauren's Classification Recruiting NCT03380052
36 The GAstric Precancerous Conditions Study Recruiting NCT04191551
37 A Series of Prospective Observational Studies Investigating the Clinical Utility of Image-enhanced Endoscopy in the Gastrointestinal (GI) Tract Recruiting NCT04085211
38 Metabonomics Study of Chronic Gastritis and Gastric Carcinoma Recruiting NCT04624282
39 Follow-up Study of Chinese Medicine for the Treatment of Chronic Atrophic Gastritis Based on Histological Evaluation Enrolling by invitation NCT02955134 Talcid®;Chinese medicine prescription;Placebo;Compound Azimtamide Entieric-coated Tablets
40 Volatile Organic Compounds in Breath and Headspace Analysis - Diagnostic and Monitoring Markers for Diseases Enrolling by invitation NCT03228095
41 A Novel Approach to the Surveillance of Pre-Malignant Gastric Lesions Not yet recruiting NCT04251403 Early Phase 1
42 Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach Not yet recruiting NCT04022109

Search NIH Clinical Center for Atrophic Gastritis

Cochrane evidence based reviews: gastritis, atrophic

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Genetic Tests for Atrophic Gastritis

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Anatomical Context for Atrophic Gastritis

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MalaCards organs/tissues related to Atrophic Gastritis:

40
Thyroid, Spleen, Endothelial, Liver, T Cells, Pancreas, Bone Marrow
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Publications for Atrophic Gastritis

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Articles related to Atrophic Gastritis:

(show top 50) (show all 4048)
# Title Authors PMID Year
1
Accuracy of serum pepsinogens I and II, gastrin-17 and anti-helicobacter pylori antibodies in histological diagnoses of atrophic gastritis. 54 61
20190719 2010
2
Helicobacter pylori eradication prevents extension of intestinalization even in the high-risk group for gastric cancer. 61 54
20110706 2010
3
The relationship between Helicobacter pylori infection and gastric adenocarcinoma in Northern Iran. 54 61
20377133 2010
4
False-positive secretin stimulation test for gastrinoma associated with the use of proton pump inhibitor therapy. 54 61
19245850 2009
5
Importance of gastrin in the pathogenesis and treatment of gastric tumors. 61 54
19115463 2009
6
Ghrelin and Helicobacter pylori infection. 61 54
19009647 2008
7
Plasma obestatin levels in men with chronic atrophic gastritis. 54 61
18588931 2008
8
[Serological diagnosis of atrophic gastritis with a combination of pepsinogen I and II, gastrin-17 and anti-Helicobacter pylori antibodies]. 61 54
18028850 2007
9
Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis. 61 54
18057384 2007
10
[Expression of hepatocyte growth factor and its receptor in gastric cancer]. 54 61
18024311 2007
11
Diversity of Helicobacter pylori cagA and vacA genes in Costa Rica: its relationship with atrophic gastritis and gastric cancer. 61 54
17760724 2007
12
Atrophic gastritis, Helicobacter pylori, and colorectal cancer risk: a case-control study. 54 61
17669106 2007
13
Chromogranin A: is it a useful marker of neuroendocrine tumors? 61 54
17513802 2007
14
Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions. 54 61
17569126 2007
15
Influence of H pylori on plasma ghrelin in patients without atrophic gastritis. 61 54
17461454 2007
16
Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies. 54 61
17261130 2007
17
Diagnosis and differential diagnosis of hypergastrinemia. 54 61
17985088 2007
18
Is GastroPanel serum assay useful in the diagnosis of Helicobacter pylori infection and associated gastritis in children? 61 54
16949782 2007
19
Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression. 61 54
17209848 2006
20
Review article: Pathogenesis and management of gastric carcinoid tumours. 54 61
17059512 2006
21
Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease. 61 54
16969140 2006
22
Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer. 61 54
16718800 2006
23
[Expression of intestine-specific transcription factor CDX2 in different subtypes of intestinal metaplasia and gastric carcinoma]. 61 54
16480583 2006
24
[Expression and significance of caudal type transcription factor-2 in gastric mucosa at different stages of gastric carcinogenesis]. 61 54
16677504 2006
25
Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. 61 54
16284368 2005
26
One-year follow-up study of patients with enterochromaffin-like cell carcinoids after treatment with octreotide long-acting release. 54 61
16334435 2005
27
[BabA2, oipA and cagE Helicobacter pylori genotypes in Colombian patients with gastroduodenal diseases]. 61 54
16276680 2005
28
Multifocal atrophic gastritis: pathogenesis and therapeutic implications. 61 54
16003136 2005
29
Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. 54 61
15887103 2005
30
Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. 54 61
15932170 2005
31
Study on the pathophysiologic basis of classification of 'spleen' deficiency in chronic gastritis. 61 54
15788127 2005
32
Morpho-functional comparisons in Helicobacter pylori-associated chronic atrophic gastritis. 61 54
16358962 2005
33
Possibility of non-invasive diagnosis of gastric mucosal precancerous changes. 54 61
15457561 2004
34
Clinical significance of elevated serum chromogranin A levels. 61 54
15513336 2004
35
Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pylori. 61 54
15447749 2004
36
Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio--a possible novel and non-invasive marker for gastric atrophy. 54 61
15362725 2004
37
The aging/precancerous gastric mucosa: a pilot nutraceutical trial. 61 54
15247013 2004
38
[The expression of trefoil factor 1 and trefoil factor 2 in gastric cancer and precancer]. 54 61
15059374 2004
39
Severe atrophic gastritis with extreme hypergastrinemia and gene expression of ornithine decarboxylase (ODC) and cyclo-oxygenase-2 (COX-2) expression: comparison with gastric cancer. 54 61
14679338 2004
40
The non-invasive diagnosis of precancerous changes of stomach mucosa. 61 54
15631316 2004
41
Co-existence of hyperparathyroidism, hypergastrinaemia and multiple gastric carcinoids is not always due to incomplete expression of the MEN-1 syndrome. 61 54
14567464 2003
42
H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis. 54 61
12883469 2003
43
The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells. 54 61
12925139 2003
44
Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa. 54 61
12717829 2003
45
The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa. 54 61
12552462 2003
46
Gene expression of ornithine decarboxylase, cyclooxygenase-2, and gastrin in atrophic gastric mucosa infected with Helicobacter pylori before and after eradication therapy. 61 54
12645788 2003
47
Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study. 61 54
12190091 2002
48
[Helicobacter pylori genotypes in non atrophic gastritis are different of the found in peptic ulcer, premalignant lesions and gastric cancer in Colombia]. 54 61
11974526 2002
49
One more dysplasia. 61 54
11742188 2001
50
Age and bioavailability of alcohol. 61 54
11558069 2001
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Variations for Atrophic Gastritis

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Expression for Atrophic Gastritis

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Search GEO for disease gene expression data for Atrophic Gastritis.
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Pathways for Atrophic Gastritis

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Pathways related to Atrophic Gastritis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Shigellosis 36
12.3 TP53 TNF IL1B CXCL8
2
IL-17 Family Signaling Pathways 64
Show member pathways
 12.22 TNF S100A8 IL1B CXCL8
3
Toll Comparative Pathway 63
Show member pathways
 12.21 TP53 TNF IL1B CXCL8
4
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.12 TP53 TNF IL1B IL10 CXCL8
5
Yersinia infection 36
11.93 TNF IL1B IL10 CXCL8
6
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.86 TNF IL1RN IL1B IL10 CXCL8
7
Spinal Cord Injury 1
11.81 TP53 TNF IL1B CXCL8
8
Innate Lymphoid Cell Differentiation Pathways 64
11.68 TNF IL1B IL10
9
Amoebiasis 36
11.68 TNF IL1B IL10 CXCL8
10
Th1 Differentiation Pathway 64
Show member pathways
 11.66 TNF IL1B IL10
11
Dendritic Cells Developmental Lineage Pathway 64
11.64 TNF IL1B IL10
12
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.55 TNF IL1B CXCL8
13
Lung fibrosis 1
11.54 TNF IL1B CXCL8
14
Pertussis 36
11.5 TNF IL1B IL10 CXCL8
15
Legionellosis 36
11.48 TNF IL1B CXCL8
16
Interleukin-4 and 13 signaling 65
11.41 TP53 TNF IL1B IL10 CXCL8
17
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.37 TNF IL1B CDX2
18
Surfactant metabolism 65
Show member pathways
 11.33 PGA5 PGA4 PGA3
19
African trypanosomiasis 36
11.22 TNF IL1B IL10
20
IL-10 Pathway 63
11.18 TNF IL1B IL10
21
Malaria 36
11.16 TNF IL1B IL10 CXCL8
22
Cytokines and Inflammatory Response 1
11.04 TNF IL1B IL10
23
Interleukin-10 signaling 65
10.71 TNF IL1RN IL1B IL10 CXCL8
24
Gastric acid production 1
10.4 MUC6 GAST
Sources

GO Terms for Atrophic Gastritis

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Cellular components related to Atrophic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNF TFF2 S100A8 PGC MUC6 IL1RN
2 extracellular region GO:0005576 9.5 TNF TFF2 S100A8 PGC PGA5 PGA4
3 multivesicular body lumen GO:0097486 9.33 PGA5 PGA4 PGA3

Biological processes related to Atrophic Gastritis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 TP53 TNF IL1B ERCC6 CXCL8
2 immune response GO:0006955 9.97 TNF IL1RN IL1B IL10 CXCL8
3 inflammatory response GO:0006954 9.89 TNF S100A8 IL1RN IL1B CXCL8
4 cellular response to lipopolysaccharide GO:0071222 9.76 TNF IL1B IL10 CXCL8
5 negative regulation of interleukin-6 production GO:0032715 9.72 TNF IL10 GHRL
6 response to glucocorticoid GO:0051384 9.71 TNF IL1RN IL10
7 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL1B
8 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.61 TP53 TNF
9 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.6 IL1RN IL10
10 response to molecule of bacterial origin GO:0002237 9.59 IL10 CXCL8
11 regulation of establishment of endothelial barrier GO:1903140 9.57 TNF IL1B
12 response to salt stress GO:0009651 9.56 TP53 TNF
13 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.54 TP53 TNF IL10
14 endothelial cell apoptotic process GO:0072577 9.52 TNF IL10
15 vascular endothelial growth factor production GO:0010573 9.51 TNF IL1B
16 negative regulation of mitotic cell cycle GO:0045930 9.5 TP53 TNF IL10
17 negative regulation of cytokine production involved in immune response GO:0002719 9.48 TNF IL10
18 positive regulation of fever generation GO:0031622 9.43 TNF IL1B
19 cytokine-mediated signaling pathway GO:0019221 9.43 TP53 TNF IL1RN IL1B IL10 CXCL8
20 sequestering of triglyceride GO:0030730 9.4 TNF IL1B
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.33 TNF IL1B IL10
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 TNF IL1B
23 digestion GO:0007586 8.92 PGC PGA5 PGA4 PGA3

Molecular functions related to Atrophic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL1RN IL1B IL10 CXCL8
2 protein tyrosine kinase activator activity GO:0030296 9.16 GHRL ERCC6
3 aspartic-type endopeptidase activity GO:0004190 8.92 PGC PGA5 PGA4 PGA3
Sources

Sources for Atrophic Gastritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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