MCID: ATR073
MIFTS: 25

Atrophic Glossitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Atrophic Glossitis

MalaCards integrated aliases for Atrophic Glossitis:

Name: Atrophic Glossitis 12 15
Atrophy of Tongue Papillae 12 73
Smooth Atrophic Tongue 12
Glossitis, Hunter's 12
Hunter's Glossitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1453
ICD10 33 K14.4
ICD9CM 35 529.4
UMLS 73 C0155964

Summaries for Atrophic Glossitis

MalaCards based summary : Atrophic Glossitis, also known as atrophy of tongue papillae, is related to geographic tongue and celiac disease 1, and has symptoms including glossalgia An important gene associated with Atrophic Glossitis is TTR (Transthyretin). The drugs Hydroxocobalamin and Iron have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and heart.

Related Diseases for Atrophic Glossitis

Diseases related to Atrophic Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 geographic tongue 31.0 HLA-A HLA-DQB2 IL36RN WHRN
2 celiac disease 1 29.9 HLA-A HLA-DQB2
3 glossitis 11.6
4 homocysteinemia 10.0
5 deficiency anemia 10.0
6 vitamin b12 deficiency 10.0
7 burning mouth syndrome 10.0
8 stomatitis 10.0
9 aphthous stomatitis 10.0
10 sutton disease 2 10.0
11 glaucomatocyclitic crisis 9.8 HLA-A HLA-DQB2

Graphical network of the top 20 diseases related to Atrophic Glossitis:



Diseases related to Atrophic Glossitis

Symptoms & Phenotypes for Atrophic Glossitis

UMLS symptoms related to Atrophic Glossitis:


glossalgia

Drugs & Therapeutics for Atrophic Glossitis

Drugs for Atrophic Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
2
Iron Approved Not Applicable 7439-89-6 23925
3
leucovorin Approved Not Applicable 58-05-9 6006 143
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
6
Cobalamin Experimental Not Applicable 13408-78-1 6438156
7 Trace Elements Not Applicable
8 Immunologic Factors Not Applicable
9 Vitamin B 12 Not Applicable
10 Vitamin B9 Not Applicable
11 Autoantibodies Not Applicable
12 Vitamin B Complex Not Applicable
13 Micronutrients Not Applicable
14 Hematinics Not Applicable
15 Vitamins Not Applicable
16 Folate Not Applicable
17 Immunoglobulins Not Applicable
18 Vitamin B12 Not Applicable
19 Antibodies Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable
2 Oral Lesions In Non-Celiac Wheat Sensitivity Patients Recruiting NCT02421809

Search NIH Clinical Center for Atrophic Glossitis

Genetic Tests for Atrophic Glossitis

Anatomical Context for Atrophic Glossitis

MalaCards organs/tissues related to Atrophic Glossitis:

41
Tongue, Colon, Heart, Thyroid

Publications for Atrophic Glossitis

Articles related to Atrophic Glossitis:

(show all 16)
# Title Authors Year
1
Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis. ( 29572125 )
2018
2
Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. ( 29653880 )
2018
3
Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients. ( 30087017 )
2018
4
The Candida species that are important for the development of atrophic glossitis in xerostomia patients. ( 29246167 )
2017
5
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. ( 27839675 )
2016
6
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. ( 23130817 )
2013
7
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. ( 22188475 )
2012
8
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. ( 22762365 )
2012
9
Atrophic glossitis leading to the diagnosis of celiac disease. ( 17568041 )
2007
10
Atrophic glossitis from vitamin B12 deficiency: a case misdiagnosed as burning mouth disorder. ( 17209796 )
2006
11
Helicobacter pylori colonization of tongue mucosa--increased incidence in atrophic glossitis and burning mouth syndrome (BMS). ( 11555160 )
2001
12
The association between atrophic glossitis and protein-calorie malnutrition in old age. ( 10690695 )
2000
13
Nutritional correlates of atrophic glossitis: possible role of vitamin E in papillary atrophy. ( 8440811 )
1993
14
Iron status in atrophic glossitis: a pilot study. ( 8266715 )
1993
15
Laboratory measurements of nutritional status as correlates of atrophic glossitis. ( 1902511 )
1991
16
Acute atrophic glossitis after open-heart surgery. ( 3406691 )
1988

Variations for Atrophic Glossitis

Expression for Atrophic Glossitis

Search GEO for disease gene expression data for Atrophic Glossitis.

Pathways for Atrophic Glossitis

GO Terms for Atrophic Glossitis

Cellular components related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.16 HLA-DQB2 TMEM79
2 ER to Golgi transport vesicle membrane GO:0012507 8.96 HLA-A HLA-DQB2
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.62 HLA-A HLA-DQB2

Biological processes related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.43 HLA-A HLA-DQB2 IL36RN
2 immune response GO:0006955 9.33 HLA-A HLA-DQB2 IL36RN
3 interferon-gamma-mediated signaling pathway GO:0060333 8.96 HLA-A HLA-DQB2
4 antigen processing and presentation GO:0019882 8.62 HLA-A HLA-DQB2

Sources for Atrophic Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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