MCID: ATR073
MIFTS: 28

Atrophic Glossitis

Categories: Gastrointestinal diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Atrophic Glossitis

MalaCards integrated aliases for Atrophic Glossitis:

Name: Atrophic Glossitis 12 15
Atrophy of Tongue Papillae 12 70 32
Smooth Atrophic Tongue 12
Glossitis, Hunter's 12
Hunter's Glossitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1453
ICD9CM 34 529.4
SNOMED-CT 67 196586009
ICD10 32 K14.4
UMLS 70 C0155964

Summaries for Atrophic Glossitis

MalaCards based summary : Atrophic Glossitis, also known as atrophy of tongue papillae, is related to glossitis and geographic tongue, and has symptoms including glossalgia An important gene associated with Atrophic Glossitis is TTR (Transthyretin). The drugs Levoleucovorin and Iron have been mentioned in the context of this disorder. Affiliated tissues include tongue and thyroid.

Related Diseases for Atrophic Glossitis

Diseases related to Atrophic Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 glossitis 32.3 TTR IL36RN
2 geographic tongue 30.3 S100P LNP1 IL36RN IL1RL2 HLA-DQB1 HLA-A
3 celiac disease 1 30.0 TG HLA-DQB1 HLA-A
4 homocysteinemia 10.5
5 vitamin b12 deficiency 10.5
6 deficiency anemia 10.5
7 pernicious anemia 10.5
8 iron metabolism disease 10.4
9 iron deficiency anemia 10.3
10 macrocytic anemia 10.3
11 gastritis 10.3
12 thalassemia 10.3
13 impetigo herpetiformis 10.2 IL36RN IL1RL2
14 atrophic gastritis 10.2
15 stomatitis 10.2
16 aphthous stomatitis 10.2
17 sutton disease 2 10.2
18 pustulosis of palm and sole 10.2 IL36RN IL1RL2
19 periostitis 10.2 IL36RN IL1RL2
20 neutrophilic dermatosis, acute febrile 10.2 IL36RN IL1RL2
21 psoriasis 14, pustular 10.2 IL36RN IL1RL2
22 pityriasis rubra pilaris 10.2 IL36RN IL1RL2
23 pediatric multiple sclerosis 10.2 TTR HLA-DQB1
24 microcytic anemia 10.1
25 candidiasis 10.1
26 burning mouth syndrome 10.1
27 htlv-1 associated myelopathy/tropical spastic paraparesis 10.1 HLA-DQB1 HLA-A
28 pityriasis rosea 10.1 HLA-DQB1 HLA-A
29 headache 10.1
30 alveolar echinococcosis 10.0 HLA-DQB1 HLA-A
31 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-A
32 cytomegalovirus retinitis 10.0 HLA-DQB1 HLA-A
33 pericardium disease 10.0 TTR MB
34 pure red-cell aplasia 10.0 HLA-DQB1 HLA-A
35 autoimmune gastritis 10.0 HLA-DQB1 HLA-A
36 schopf-schulz-passarge syndrome 10.0 HLA-DQB1 HLA-A
37 neuropathy, hereditary sensory and autonomic, type iii 10.0
38 megaloblastic anemia 10.0
39 hypothyroidism 10.0
40 hyperthyroidism 10.0
41 47,xyy 10.0
42 autoimmune atrophic gastritis 10.0
43 glossodynia 10.0
44 dysautonomia 10.0
45 idiopathic bronchiectasis 10.0 HLA-DQB1 HLA-A
46 vogt-koyanagi-harada disease 9.9 HLA-DQB1 HLA-A
47 graft-versus-host disease 9.9 HLA-DQB1 HLA-A
48 graves' disease 9.9 TG HLA-DQB1 HLA-A
49 optic neuritis 9.8 HLA-DQB1 HLA-A
50 severe cutaneous adverse reaction 9.7 HLA-DQB1 HLA-A

Graphical network of the top 20 diseases related to Atrophic Glossitis:



Diseases related to Atrophic Glossitis

Symptoms & Phenotypes for Atrophic Glossitis

UMLS symptoms related to Atrophic Glossitis:


glossalgia

Drugs & Therapeutics for Atrophic Glossitis

Drugs for Atrophic Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational 68538-85-2 149436
2
Iron Approved 7439-89-6 23925 29936
3
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
4
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
5
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
6
Cobalamin Experimental 13408-78-1 6857388
7 Vitamin B9
8 Trace Elements
9 Nutrients
10 Hematinics
11 Vitamins
12 Antibodies
13 Immunoglobulins
14 Vitamin B Complex
15 Folate
16 Vitamin B12
17 Micronutrients
18 Vitamin B 12
19 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293

Search NIH Clinical Center for Atrophic Glossitis

Genetic Tests for Atrophic Glossitis

Anatomical Context for Atrophic Glossitis

MalaCards organs/tissues related to Atrophic Glossitis:

40
Tongue, Thyroid

Publications for Atrophic Glossitis

Articles related to Atrophic Glossitis:

(show top 50) (show all 87)
# Title Authors PMID Year
1
Pyoderma gangrenosum and cobalamin deficiency in systemic lupus erythematosus: a rare but non fortuitous association. 61
33653418 2021
2
Atrophic glossitis in pernicious anemia patients can be treated to normal in two weeks by intramuscular injection of vitamin B12. 61
33505632 2020
3
[Related factors of atrophic glossitis in 124 consecutive cases]. 61
33089295 2020
4
Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with normocytosis. 61
31362840 2020
5
Smart link of chronic atrophic gastritis with atrophic glossitis, gastric parietal cell antibody positivity, vitamin B12 deficiency, and hyperhomocysteinemia. 61
32024596 2020
6
Is chronic atrophic gastritis the missing link between atrophic glossitis, gastric parietal cell antibody positivity and hematological deficiencies? 61
31992475 2020
7
Atrophic glossitis: Etiology, serum autoantibodies, anemia, hematinic deficiencies, hyperhomocysteinemia, and management. 61
31076315 2020
8
Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with vitamin B12 deficiency. 61
31630933 2020
9
Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with iron deficiency. 61
31607629 2020
10
Does serum gastric parietal cell antibody titer have influence on anemia and vitamin B12 deficiency in atrophic glossitis patients? 61
31277918 2020
11
Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in atrophic glossitis patients with or without hyperhomocysteinemia. 61
31444017 2020
12
Prevalence of and related risk factors in oral mucosa diseases among residents in the Baoshan District of Shanghai, China. 61
32140308 2020
13
Thirteen maxillary full dentures over 10 years: A case of peripheral painful traumatic trigeminal neuropathy. 61
31447327 2019
14
Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with macrocytosis. 61
31324439 2019
15
Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients with or without microcytosis. 61
31242967 2019
16
Atrophic Glossitis. 61
31618542 2019
17
Diarrhea: a missed D in the 4D glucagonoma syndrome. 61
31807436 2019
18
Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity. 61
31005374 2019
19
Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative atrophic glossitis patients. 61
30979649 2019
20
Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. 61
30736997 2019
21
Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients. 61
30581105 2019
22
Prevalence of Dental Enamel Defects, Aphthous-Like Ulcers and Other Oral Manifestations in Celiac Children and Adolescents: A Comparative Study. 61
31283894 2019
23
Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients. 61
30087017 2018
24
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. 61
29753458 2018
25
Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. 61
29653880 2018
26
[Clinical analysis for oral mucosal disease in 21 972 cases]. 61
30124215 2018
27
Oral lesions in Sjogren's syndrome: A systematic review. 61
29924754 2018
28
Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis. 61
29572125 2018
29
The Candida species that are important for the development of atrophic glossitis in xerostomia patients. 61
29246167 2017
30
Morphea "en coup de sabre": An unusual oral presentation. 61
28210455 2017
31
Oral mucosa lesions in patients with active Crohn’s disease - a prospective study. 61
29694006 2017
32
Oral Manifestations in Pediatric Patients with Coeliac Disease - A Review Article. 61
29238414 2017
33
Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. 61
27793414 2017
34
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. 61
27839675 2016
35
Perception of iron deficiency from oral mucosa alterations that show a high prevalence of Candida infection. 61
27133388 2016
36
Serum zinc levels in 368 patients with oral mucosal diseases: A preliminary study. 61
27031065 2016
37
Diagnosis of Lingual Atrophic Conditions: Associations with Local and Systemic Factors. A Descriptive Review. 61
27990187 2016
38
Oral manifestations of plummer-vinson syndrome: a classic report with literature review. 61
25878483 2015
39
[Study on the correlation of epidermal growth factor and Sjoigren's syndrome with atrophic glossitis]. 61
25636292 2014
40
Celiac disease and its impact on the oral health status - review of the literature. 61
25491679 2014
41
Plummer-Vinson syndrome following gastric bypass surgery. 61
25255352 2014
42
A case of plummer-vinson syndrome associated with Crohn's disease. 61
24755750 2014
43
Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms. 61
24303868 2014
44
Oral manifestations and blood profile in patients with iron deficiency anemia. 61
24388269 2014
45
Oral manifestations and blood profile in patients with thalassemia trait. 61
24139948 2013
46
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. 61
23130817 2013
47
[Atrophic glossitis is attributed to cobalamin deficiency]. 61
23552783 2013
48
[Research on flora on tongue dorsum of patients with atrophic glossitis and correlated factors]. 61
23173324 2012
49
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. 61
22188475 2012
50
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. 61
22762365 2012

Variations for Atrophic Glossitis

Expression for Atrophic Glossitis

Search GEO for disease gene expression data for Atrophic Glossitis.

Pathways for Atrophic Glossitis

GO Terms for Atrophic Glossitis

Cellular components related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ER to Golgi transport vesicle membrane GO:0012507 8.96 HLA-DQB1 HLA-A
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.62 HLA-DQB1 HLA-A

Biological processes related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation GO:0019882 8.62 HLA-DQB1 HLA-A

Molecular functions related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DQB1 HLA-A

Sources for Atrophic Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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