MCID: ATR073
MIFTS: 33

Atrophic Glossitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Atrophic Glossitis

MalaCards integrated aliases for Atrophic Glossitis:

Name: Atrophic Glossitis 12 15
Atrophy of Tongue Papillae 12 74
Smooth Atrophic Tongue 12
Glossitis, Hunter's 12
Hunter's Glossitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1453
ICD9CM 36 529.4
ICD10 34 K14.4
UMLS 74 C0155964

Summaries for Atrophic Glossitis

MalaCards based summary : Atrophic Glossitis, also known as atrophy of tongue papillae, is related to geographic tongue and celiac disease 1, and has symptoms including glossalgia An important gene associated with Atrophic Glossitis is TTR (Transthyretin), and among its related pathways/superpathways are Allograft rejection and Phagosome. The drugs Hydroxocobalamin and Iron have been mentioned in the context of this disorder. Affiliated tissues include tongue, thyroid and colon.

Related Diseases for Atrophic Glossitis

Graphical network of the top 20 diseases related to Atrophic Glossitis:



Diseases related to Atrophic Glossitis

Symptoms & Phenotypes for Atrophic Glossitis

UMLS symptoms related to Atrophic Glossitis:


glossalgia

Drugs & Therapeutics for Atrophic Glossitis

Drugs for Atrophic Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 15589840
2
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 23925 27284
3
leucovorin Approved Not Applicable 58-05-9 6006 143
4
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
5
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
6
Cobalamin Experimental Not Applicable 13408-78-1 6857388
7 Immunoglobulins Not Applicable
8 Vitamin B 12 Not Applicable
9 Hematinics Not Applicable
10 Nutrients Not Applicable
11 Vitamin B Complex Not Applicable
12 Trace Elements Not Applicable
13 Vitamins Not Applicable
14 Antibodies Not Applicable
15 Immunologic Factors Not Applicable
16 Micronutrients Not Applicable
17 Vitamin B9 Not Applicable
18 Folate Not Applicable
19 Autoantibodies Not Applicable
20 Vitamin B12 Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable
2 Oral Lesions In Non-Celiac Wheat Sensitivity Patients Recruiting NCT02421809

Search NIH Clinical Center for Atrophic Glossitis

Genetic Tests for Atrophic Glossitis

Anatomical Context for Atrophic Glossitis

MalaCards organs/tissues related to Atrophic Glossitis:

42
Tongue, Thyroid, Colon, Heart

Publications for Atrophic Glossitis

Articles related to Atrophic Glossitis:

(show all 18)
# Title Authors Year
1
Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients. ( 30581105 )
2019
2
Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. ( 30736997 )
2019
3
Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis. ( 29572125 )
2018
4
Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. ( 29653880 )
2018
5
Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients. ( 30087017 )
2018
6
The Candida species that are important for the development of atrophic glossitis in xerostomia patients. ( 29246167 )
2017
7
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. ( 27839675 )
2016
8
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. ( 23130817 )
2013
9
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. ( 22188475 )
2012
10
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. ( 22762365 )
2012
11
Atrophic glossitis leading to the diagnosis of celiac disease. ( 17568041 )
2007
12
Atrophic glossitis from vitamin B12 deficiency: a case misdiagnosed as burning mouth disorder. ( 17209796 )
2006
13
Helicobacter pylori colonization of tongue mucosa--increased incidence in atrophic glossitis and burning mouth syndrome (BMS). ( 11555160 )
2001
14
The association between atrophic glossitis and protein-calorie malnutrition in old age. ( 10690695 )
2000
15
Nutritional correlates of atrophic glossitis: possible role of vitamin E in papillary atrophy. ( 8440811 )
1993
16
Iron status in atrophic glossitis: a pilot study. ( 8266715 )
1993
17
Laboratory measurements of nutritional status as correlates of atrophic glossitis. ( 1902511 )
1991
18
Acute atrophic glossitis after open-heart surgery. ( 3406691 )
1988

Variations for Atrophic Glossitis

Expression for Atrophic Glossitis

Search GEO for disease gene expression data for Atrophic Glossitis.

Pathways for Atrophic Glossitis

Pathways related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.54 HLA-A HLA-DQB1 TG
2 11.34 HLA-A HLA-DQB1
3 11.11 HLA-A HLA-DQB1

GO Terms for Atrophic Glossitis

Cellular components related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.16 HLA-DQB1 TMEM79
2 ER to Golgi transport vesicle membrane GO:0012507 8.96 HLA-A HLA-DQB1
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.62 HLA-A HLA-DQB1

Biological processes related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.43 HLA-A HLA-DQB1 IL36RN
2 interferon-gamma-mediated signaling pathway GO:0060333 9.16 HLA-A HLA-DQB1
3 regulation of signaling receptor activity GO:0010469 9.13 IL36RN TG TTR
4 antigen processing and presentation GO:0019882 8.62 HLA-A HLA-DQB1

Molecular functions related to Atrophic Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 TG TTR
2 peptide antigen binding GO:0042605 8.62 HLA-A HLA-DQB1

Sources for Atrophic Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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