MCID: ATR052
MIFTS: 21

Atrophic Lichen Planus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Atrophic Lichen Planus

MalaCards integrated aliases for Atrophic Lichen Planus:

Name: Atrophic Lichen Planus 52 58 71
Atrophic Lp 52 58

Characteristics:

Orphanet epidemiological data:

58
atrophic lichen planus
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 33 L43.8
UMLS via Orphanet 72 C0023647
Orphanet 58 ORPHA254449
UMLS 71 C0023647

Summaries for Atrophic Lichen Planus

NIH Rare Diseases : 52 Atrophic lichen planus (LP) is a rare form of lichen planus , which is a condition that affects the skin and/or mouth. In atrophic LP, specifically, affected people develop pale papules or plaques with an atrophic (broken down tissue ) center. Although these papules can be found anywhere on the body, they most commonly affect the trunk and/or legs on skin areas previously affected by classic lichen planus. The exact underlying cause of atrophic LP is unknown. Treatment is not always necessary as some cases of atrophic LP resolve on their own. Mild cases can often be managed with topical steroids , while more intensive therapies may be required for severe cases.

MalaCards based summary : Atrophic Lichen Planus, also known as atrophic lp, is related to annular atrophic lichen planus and lichen planus. An important gene associated with Atrophic Lichen Planus is DSC1 (Desmocollin 1). The drugs Miconazole and Pimecrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Atrophic Lichen Planus

Diseases related to Atrophic Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 annular atrophic lichen planus 13.0
2 lichen planus 10.9
3 oral lichen planus 10.4
4 cutis laxa 10.3
5 acquired cutis laxa 10.3
6 keratosis 10.1
7 cerebrovascular disease 10.1
8 annular lichen planus 10.1
9 oral cancer 10.1

Graphical network of the top 20 diseases related to Atrophic Lichen Planus:



Diseases related to Atrophic Lichen Planus

Symptoms & Phenotypes for Atrophic Lichen Planus

Drugs & Therapeutics for Atrophic Lichen Planus

Drugs for Atrophic Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 17753757 6447131
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
5
Lactitol Investigational Phase 4 585-88-6, 585-86-4 493591
6 Immunologic Factors Phase 4
7 Anti-Asthmatic Agents Phase 4
8 Antifungal Agents Phase 4
9 Respiratory System Agents Phase 4
10 glucocorticoids Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Dermatologic Agents Phase 4
13 Analgesics Phase 4
14 Betamethasone-17,21-dipropionate Phase 4
15 Hormone Antagonists Phase 4
16 Betamethasone Valerate Phase 4 2152-44-5
17 Immunosuppressive Agents Phase 4
18 Antirheumatic Agents Phase 4
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4
20 Calcineurin Inhibitors Phase 4
21 Betamethasone benzoate Phase 4
22 Anti-Inflammatory Agents Phase 4
23 Betamethasone sodium phosphate Phase 4
24 Hormones Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparative Clinical and Immunohistochemical Study Between Topical Pimecrolimus and Corticosteroid in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream

Search NIH Clinical Center for Atrophic Lichen Planus

Genetic Tests for Atrophic Lichen Planus

Anatomical Context for Atrophic Lichen Planus

MalaCards organs/tissues related to Atrophic Lichen Planus:

40
Skin

Publications for Atrophic Lichen Planus

Articles related to Atrophic Lichen Planus:

(show all 43)
# Title Authors PMID Year
1
Isolated annular atrophic lichen planus of the mammary areola. 61
31198992 2019
2
Annular atrophic lichen planus. 61
31308186 2019
3
Annular atrophic lichen planus as a psychiatric problem. 61
29193709 2017
4
Annular atrophic lichen planus responds to hydroxychloroquine and acitretin. 61
28961283 2017
5
Annular atrophic lichen planus: a rare clinical entity. 61
28557285 2017
6
[Two annular, atrophic plaques on the abdomen of a 35-year-old man]. 61
27757492 2017
7
Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review. 61
27659090 2016
8
A Comparative Evaluation of Low-Level Laser and Topical Steroid Therapies for the Treatment of Erosive-Atrophic Lichen Planus. 61
27275271 2015
9
Plasma cell gingivitis. 61
26015677 2015
10
Removal of refractory erosive-atrophic lichen planus by the CO2 laser. 61
25284518 2014
11
Human papillomavirus in oral atrophic lichen planus lesions. 61
22658678 2012
12
Letter:Annular atrophic lichen planus of the lip. 61
22398235 2012
13
A comparative pilot study of low intensity laser versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus. 61
21214369 2011
14
Annular atrophic lichen planus. 61
20822974 2010
15
[Atrophic lichen planus annularis: presentation of 3 cases]. 61
20109404 2010
16
Desmocollin expression in oral atrophic lichen planus correlates with clinical behavior and DNA content. 61
18422976 2008
17
Annular atrophic lichen planus associated with hypertrophic lichen planus. 61
18076696 2008
18
A case of annular atrophic lichen planus. 61
17659019 2007
19
Annular atrophic lichen planus. 61
17472678 2007
20
A clinical study of 674 patients with oral lichen planus in China. 61
16091113 2005
21
A clinical and epidemiological study of lichen planus among Egyptians of al-Minya province. 61
16150212 2005
22
Annular atrophic lichen planus. 61
15858488 2005
23
Klinefelter's syndrome presenting with leg ulcers. 61
15365265 2004
24
Atrophic lichen planus. 61
15022509 2004
25
Annular atrophic lichen planus. 61
12920380 2003
26
Annular atrophic lichen planus and Sneddon's syndrome. 61
9529568 1997
27
Annular atrophic lichen planus. 61
8003802 1994
28
[Oral lichen planus and cancer. Apropos of 2 cases]. 61
8456245 1993
29
[Lichen ruber hypertrophicus with verrucous carcinoma]. 61
1468932 1992
30
Annular atrophic lichen planus. 61
1894780 1991
31
A case of atrophic lichen planus in association with addisonian pernicious anaemia. 61
3487399 1986
32
ATROPHIC LICHEN PLANUS. 61
14072614 1963
33
Atrophic lichen planus? poikiloderma? 61
18145557 1949
34
Generalized annular atrophic lichen planus eruption due to quinacrine hydrochloride. 61
18101527 1948
35
A case for diagnosis (atrophic lichen planus?). 61
20995046 1946
36
Poikiloderma Jacobi? atrophic lichen planus? 61
20993126 1946
37
Poikiloderma Jacobi: Atrophic Lichen Planus. 61
19993329 1946
38
Two Cases of Atrophic Lichen Planus in Women. 61
19991642 1938
39
Pigmentary and Atrophic Lichen Planus following the Administration of Arsenic and Bismuth. 61
19989388 1933
40
Atrophic Lichen Planus with Morphœa-like Lesions. 61
20912771 1931
41
Atrophic Lichen Planus with Morphoea-like Lesions. 61
19988374 1931
42
Case of Atrophic Lichen Planus in a Woman, aged 40. 61
19982829 1923
43
Atrophic Lichen Planus with Cornu Cutaneum. 61
19974954 1911

Variations for Atrophic Lichen Planus

Expression for Atrophic Lichen Planus

Search GEO for disease gene expression data for Atrophic Lichen Planus.

Pathways for Atrophic Lichen Planus

GO Terms for Atrophic Lichen Planus

Sources for Atrophic Lichen Planus

3 CDC
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9 Cosmic
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11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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