MCID: ATR076
MIFTS: 34

Atrophic Muscular Disease

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Atrophic Muscular Disease

MalaCards integrated aliases for Atrophic Muscular Disease:

Name: Atrophic Muscular Disease 12 15
Muscular Disorders, Atrophic 45

Classifications:



External Ids:

Disease Ontology 12 DOID:913
MeSH 45 D020966
NCIt 51 C84574
UMLS 74 C0752352

Summaries for Atrophic Muscular Disease

Disease Ontology : 12 A neuromuscular disease that is characterized by an abnormal reduction in the muscle volume and atrophy.

MalaCards based summary : Atrophic Muscular Disease, also known as muscular disorders, atrophic, is related to pseudomyotonia and muscular disease. An important gene associated with Atrophic Muscular Disease is ATP2A1 (ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CREB Pathway. The drugs Carvedilol and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and heart, and related phenotype is muscle.

Related Diseases for Atrophic Muscular Disease

Diseases related to Atrophic Muscular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 5, show less)
# Related Disease Score Top Affiliating Genes
1 pseudomyotonia 9.8 ATP2A1 ATP2A2
2 muscular disease 9.8 ATP2A1 RYR1
3 darier-white disease 9.7 ATP2A2 ATP2A3
4 myopathy, tubular aggregate, 1 9.5 ATP2A1 RYR1
5 brody myopathy 8.8 ATP2A1 ATP2A2 ATP2A3 CAMP RYR1

Graphical network of the top 20 diseases related to Atrophic Muscular Disease:



Diseases related to Atrophic Muscular Disease

Symptoms & Phenotypes for Atrophic Muscular Disease

MGI Mouse Phenotypes related to Atrophic Muscular Disease:

47 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 ATP2A1 ATP2A2 ATP2A3 RYR1

Drugs & Therapeutics for Atrophic Muscular Disease

Drugs for Atrophic Muscular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 272, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Ramipril Approved Phase 4 87333-19-5 5362129
3
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 1,Early Phase 1,Not Applicable 171596-29-5 110635
4
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
5
Alendronate Approved Phase 4 66376-36-1, 121268-17-5 2088
6
Calcium Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 7440-70-2 271
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
8 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
9 Adrenergic alpha-Antagonists Phase 4
10 calcium channel blockers Phase 4,Phase 3
11
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
12 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
13 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
14 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Not Applicable
16 Adrenergic alpha-1 Receptor Antagonists Phase 4
17 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3
19 Adrenergic Antagonists Phase 4,Phase 2,Phase 3
20 Adrenergic Agents Phase 4,Phase 2,Phase 3,Not Applicable
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Calcium, Dietary Phase 4,Phase 3,Not Applicable
23 Antioxidants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Anti-Bacterial Agents Phase 4,Phase 2,Phase 1
25 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
26 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
27 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
28 Antibiotics, Antitubercular Phase 4
29 Bone Density Conservation Agents Phase 4,Phase 3,Phase 1,Not Applicable
30 Calciferol Phase 4
31 Diphosphonates Phase 4
32
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
33
tannic acid Approved Phase 3,Not Applicable 1401-55-4
34
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
35
Deflazacort Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 14484-47-0
36
Glucosamine Approved, Investigational Phase 3,Phase 2 3416-24-8 439213
37
Eplerenone Approved Phase 3,Not Applicable 107724-20-9 443872 150310
38
Spironolactone Approved Phase 3,Phase 1 1952-01-7, 52-01-7 5833
39
Metformin Approved Phase 3,Phase 2,Phase 1 657-24-9 14219 4091
40
Enalaprilat Approved Phase 3 76420-72-9 6917719
41
Enalapril Approved, Vet_approved Phase 3 75847-73-3 40466924 5362032
42
Lisinopril Approved, Investigational Phase 2, Phase 3,Not Applicable 83915-83-7, 76547-98-3 5362119
43
Idebenone Approved, Investigational Phase 3,Phase 2 58186-27-9
44
Dopamine Approved Phase 2, Phase 3 62-31-7, 51-61-6 681
45
Methylphenidate Approved, Investigational Phase 2, Phase 3 113-45-1 4158
46
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
47
Tamoxifen Approved Phase 3,Phase 1 10540-29-1 2733526
48
Bisoprolol Approved Phase 2, Phase 3 66722-44-9 2405
49
Nebivolol Approved, Investigational Phase 3 152520-56-4, 99200-09-6, 118457-14-0 71301
50
Modafinil Approved, Investigational Phase 3 68693-11-8 4236
51
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 2, Phase 3,Phase 3 303-98-0 5281915
52
Creatine Approved, Investigational, Nutraceutical Phase 3,Phase 2,Not Applicable 57-00-1 586
53
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 2, Phase 3 53-43-0 9860744
54
Epigallocatechin Experimental, Investigational Phase 2, Phase 3 970-74-1 72277
55
Epigallocatechin gallate Investigational Phase 2, Phase 3 989-51-5 65064
56 Hypoglycemic Agents Phase 3,Phase 2,Phase 1,Not Applicable
57 Nutrients Phase 2, Phase 3,Phase 3,Not Applicable
58 Trace Elements Phase 2, Phase 3,Phase 3,Not Applicable
59 Micronutrients Phase 2, Phase 3,Phase 3,Not Applicable
60 Immunologic Factors Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
61 glucocorticoids Phase 3,Phase 2,Phase 1
62 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Not Applicable
63 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1
64 Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
65 Sodium Channel Blockers Phase 3,Phase 2,Phase 1
66 Mineralocorticoids Phase 3,Phase 1,Not Applicable
67 Natriuretic Agents Phase 3,Phase 1,Not Applicable
68 Diuretics, Potassium Sparing Phase 3,Phase 2,Phase 1,Not Applicable
69 Mineralocorticoid Receptor Antagonists Phase 3,Phase 1,Not Applicable
70 diuretics Phase 3,Phase 1,Not Applicable
71 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
72 Tea Phase 2, Phase 3,Phase 1
73 Neuroprotective Agents Phase 2, Phase 3,Phase 1
74 Cardiotonic Agents Phase 2, Phase 3,Not Applicable
75 Ubiquinone Phase 2, Phase 3,Phase 3
76 Central Nervous System Stimulants Phase 2, Phase 3,Phase 3
77 Dopamine Agents Phase 2, Phase 3
78 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
79 Dopamine Uptake Inhibitors Phase 2, Phase 3
80 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Phase 1
81 glutamine Phase 3,Phase 2
82 Adjuvants, Immunologic Phase 2, Phase 3,Phase 1,Not Applicable
83 DHEA (Dehydroepiandrosterone) Phase 2, Phase 3
84 Antipsychotic Agents Phase 3
85 Central Nervous System Depressants Phase 3,Not Applicable
86 Psychotropic Drugs Phase 3
87 Tranquilizing Agents Phase 3
88 Anticonvulsants Phase 3
89 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
90 Rho(D) Immune Globulin Phase 3,Phase 2,Phase 1
91 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
92 Immunoglobulins, Intravenous Phase 3,Phase 2,Phase 1
93 gamma-Globulins Phase 3,Phase 2,Phase 1
94 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
95 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
96 Autonomic Agents Phase 2, Phase 3,Phase 1,Not Applicable
97 Immunoglobulin G Phase 2, Phase 3,Phase 1,Not Applicable
98 Adrenergic Agonists Phase 3,Not Applicable
99 Adrenergic beta-Agonists Phase 3,Not Applicable
100 Estrogen Receptor Antagonists Phase 3,Phase 1
101 Selective Estrogen Receptor Modulators Phase 3,Phase 1
102 Estrogens Phase 3,Phase 1
103 Estrogen Antagonists Phase 3,Phase 1
104 Estrogen Receptor Modulators Phase 3,Phase 1
105 Natriuretic Peptide, Brain Phase 2, Phase 3
106 Sympatholytics Phase 2, Phase 3
107 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
108 Cytochrome P-450 CYP3A Inducers Phase 3
109 Wakefulness-Promoting Agents Phase 3
110
Dibekacin Approved Phase 2 34493-98-6
111
Mecasermin Approved, Investigational Phase 1, Phase 2,Phase 2 68562-41-4
112
Zinc Approved, Investigational Phase 2 7440-66-6 32051
113
Prednisolone phosphate Approved, Vet_approved Phase 2,Phase 1 302-25-0
114
Prednisolone Approved, Vet_approved Phase 2,Phase 1 50-24-8 5755
115
Methylprednisolone hemisuccinate Approved Phase 2,Phase 1 2921-57-5
116
Methylprednisolone Approved, Vet_approved Phase 2,Phase 1 83-43-2 6741
117
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
118
Sodium Citrate Approved, Investigational Phase 2,Phase 1,Not Applicable 68-04-2
119
Mexiletine Approved, Investigational Phase 2 31828-71-4 4178
120
Pentoxifylline Approved, Investigational Phase 1, Phase 2,Phase 2 6493-05-6 4740
121
Histamine Approved, Investigational Phase 2 51-45-6 774
122
Cosyntropin Approved Phase 2 16960-16-0 16129617
123
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 6473866 445643 439492
124
Coal tar Approved Phase 2 8007-45-2
125
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1,Not Applicable 77-92-9 311
126
Arbekacin Experimental, Investigational Phase 2 51025-85-5 68682
127
Prednisolone hemisuccinate Experimental Phase 2,Phase 1 2920-86-7
128
Epicatechin Investigational Phase 2,Phase 1 490-46-0, 35323-91-2 72276
129
Oxatomide Investigational Phase 2 60607-34-3 4615
130 Ifetroban Investigational Phase 2 143443-90-7
131
Halofuginone Investigational, Vet_approved Phase 2,Phase 1 55837-20-2 62894
132 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
133 insulin Phase 1, Phase 2,Phase 2,Not Applicable
134 Mitogens Phase 1, Phase 2,Phase 2
135 Insulin, Globin Zinc Phase 1, Phase 2,Phase 2,Not Applicable
136 Complement Factor I Phase 2
137 Vaccines Phase 2,Phase 1,Not Applicable
138 Prednisolone acetate Phase 2,Phase 1
139 Methylprednisolone Acetate Phase 2,Phase 1
140 Gastrointestinal Agents Phase 2,Phase 1
141 Antiemetics Phase 2,Phase 1
142 Citrate Phase 2,Phase 1,Not Applicable
143 Sildenafil Citrate Phase 2,Phase 1,Not Applicable 171599-83-0
144 Anti-Arrhythmia Agents Phase 2,Not Applicable
145 Platelet Aggregation Inhibitors Phase 1, Phase 2,Phase 2
146 Free Radical Scavengers Phase 1, Phase 2,Phase 2
147 Radiation-Protective Agents Phase 1, Phase 2,Phase 2
148 Histamine Antagonists Phase 2
149 Respiratory System Agents Phase 2,Not Applicable
150 Histamine H1 Antagonists Phase 2
151 Anti-Asthmatic Agents Phase 2,Not Applicable
152 Anti-Allergic Agents Phase 2
153
Histamine Phosphate Phase 2 51-74-1 65513
154 4-des-dimethylaminotetracycline Phase 2
155 Antibodies, Monoclonal Phase 1, Phase 2,Phase 2
156 Tin Fluorides Phase 1, Phase 2
157 Antiparasitic Agents Phase 2,Phase 1
158 Antiprotozoal Agents Phase 2,Phase 1
159 Angiogenesis Inhibitors Phase 2,Phase 1
160 Angiogenesis Modulating Agents Phase 2,Phase 1
161
Nitric Oxide Approved Phase 1 10102-43-9 145068
162
AT-101 Approved, Investigational Phase 1 90141-22-3, 652-67-5 12597
163
Isosorbide Dinitrate Approved, Investigational Phase 1 87-33-2 6883
164
Ibuprofen Approved Phase 1 15687-27-1 3672
165
Ranolazine Approved, Investigational Phase 1 95635-55-5, 142387-99-3 56959
166
Testosterone Approved, Experimental, Investigational Phase 1,Not Applicable 58-22-0, 481-30-1 10204 6013
167
Methyltestosterone Approved Phase 1 58-18-4 6010
168
Testosterone undecanoate Approved, Investigational Phase 1 5949-44-0
169
Testosterone enanthate Approved Phase 1 315-37-7 9416
170
Lenograstim Approved, Investigational Phase 1 135968-09-1
171
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
172 arginine Phase 1
173 Analgesics Phase 1,Not Applicable
174 Cyclooxygenase Inhibitors Phase 1
175 Antirheumatic Agents Phase 1,Not Applicable
176 isosorbide-5-mononitrate Phase 1
177 Nitric Oxide Donors Phase 1
178 Anti-Inflammatory Agents, Non-Steroidal Phase 1
179 Analgesics, Non-Narcotic Phase 1,Not Applicable
180 Gentamicins Phase 1
181 Anabolic Agents Phase 1,Not Applicable
182 Androgens Phase 1,Not Applicable
183 Testosterone 17 beta-cypionate Phase 1
184
Tocopherol Approved, Investigational Not Applicable 1406-66-2 14986
185
Selenium Approved, Investigational, Vet_approved Not Applicable 7782-49-2
186
Oxandrolone Approved, Investigational Not Applicable 53-39-4 5878
187
Dinoprostone Approved Not Applicable 363-24-6 5280360
188
Methylcobalamin Approved, Experimental, Investigational Not Applicable 13422-55-4
189
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
190
Polyestradiol phosphate Approved Not Applicable 28014-46-2
191
Progesterone Approved, Vet_approved Not Applicable 57-83-0 5994
192
Estradiol Approved, Investigational, Vet_approved Not Applicable 50-28-2 5757
193
carbamide peroxide Approved Not Applicable 124-43-6
194
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
195
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
196
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 5311068 68602
197
Ketamine Approved, Vet_approved Not Applicable 6740-88-1 3821
198
Losartan Approved Not Applicable 114798-26-4 3961
199
Angiotensin II Approved, Investigational Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198
200
Capsaicin Approved Early Phase 1 404-86-4 1548943
201
Ethanol Approved Early Phase 1 64-17-5 702
202 Orange Approved Not Applicable
203
Vitamin E Approved, Nutraceutical, Vet_approved Not Applicable 59-02-9 14985
204
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 54670067 5785
205
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
206
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
207 Tocotrienol Investigational Not Applicable 6829-55-6
208
Cobalamin Experimental Not Applicable 13408-78-1 6857388
209
Uric acid Investigational Not Applicable