OZENA
MCID: ATR003
MIFTS: 34

Atrophic Rhinitis (OZENA)

Categories: Respiratory diseases

Aliases & Classifications for Atrophic Rhinitis

MalaCards integrated aliases for Atrophic Rhinitis:

Name: Atrophic Rhinitis 12 15 17
Rhinitis, Atrophic 12 45 74
Rhinitis Sicca 12 74
Ozena 12 74
Dry Rhinitis 12
Ozaena 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4731
MeSH 45 D012222
SNOMED-CT 69 28111002

Summaries for Atrophic Rhinitis

Disease Ontology : 12 A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

MalaCards based summary : Atrophic Rhinitis, also known as rhinitis, atrophic, is related to dacryocystitis and actinobacillosis, and has symptoms including rhinorrhea An important gene associated with Atrophic Rhinitis is XPNPEP2 (X-Prolyl Aminopeptidase 2), and among its related pathways/superpathways is MHC class II antigen presentation. The drugs Acetylcholine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and liver.

Related Diseases for Atrophic Rhinitis

Graphical network of the top 20 diseases related to Atrophic Rhinitis:



Diseases related to Atrophic Rhinitis

Symptoms & Phenotypes for Atrophic Rhinitis

UMLS symptoms related to Atrophic Rhinitis:


rhinorrhea

Drugs & Therapeutics for Atrophic Rhinitis

Drugs for Atrophic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
2 Peripheral Nervous System Agents Phase 1, Phase 2
3 abobotulinumtoxinA Phase 1, Phase 2
4 Botulinum Toxins Phase 1, Phase 2
5 Neuromuscular Agents Phase 1, Phase 2
6 Acetylcholine Release Inhibitors Phase 1, Phase 2
7 Cholinergic Agents Phase 1, Phase 2
8 Neurotransmitter Agents Phase 1, Phase 2
9 Botulinum Toxins, Type A Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Benefits of the Use of Botox in the Treatment of Empty Nose Syndrome Syndrome Terminated NCT00732680 Phase 1, Phase 2 Botulinum Toxin Type A
2 Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps Completed NCT02855931 Not Applicable
3 A Clinical Study to Evaluate the Safety and Efficacy of Platelet Rich Plasma Injection for Atrophic Rhinitis Recruiting NCT03112330 Not Applicable
4 Gore Tex Implants in the Treatment of Atrophic Rhinitis Suspended NCT00832403
5 Topical Antibiotic Use In Chronic Rhinosinusitis A Double-Blinded, Randomized, Placebo Controlled Study Withdrawn NCT00669799 Not Applicable gentamyacin;gentamyacin

Search NIH Clinical Center for Atrophic Rhinitis

Cochrane evidence based reviews: rhinitis, atrophic

Genetic Tests for Atrophic Rhinitis

Anatomical Context for Atrophic Rhinitis

MalaCards organs/tissues related to Atrophic Rhinitis:

42
Bone, Testes, Liver, Colon, Thyroid

Publications for Atrophic Rhinitis

Articles related to Atrophic Rhinitis:

(show top 50) (show all 394)
# Title Authors Year
1
Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. ( 30670313 )
2019
2
Evaluation of carbopol as an adjuvant on the effectiveness of progressive atrophic rhinitis vaccine. ( 29909135 )
2018
3
Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study. ( 30460908 )
2018
4
Is submucosal fat injection effective in atrophic rhinitis? An experimental animal study. ( 28707085 )
2017
5
Role of Histopathology in Differentiating Primary Atrophic Rhinitis from Atrophic Stage of Rhinoscleroma. ( 28239581 )
2017
6
Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. ( 28669540 )
2017
7
Empty nose syndrome and atrophic rhinitis. ( 27613452 )
2016
8
Surfactant protein a expression in chronic rhinosinusitis and atrophic rhinitis. ( 25992168 )
2015
9
Atrophic rhinitis caused by Cedecea davisae with accompanying mucocele. ( 26211869 )
2015
10
Atrophic rhinitis presenting with ethmoidal mucocele: a case report. ( 25121010 )
2014
11
Generation of an attenuated Salmonella-delivery strains expressing adhesin and toxin antigens for progressive atrophic rhinitis, and evaluation of its immune responses in a murine model. ( 25045826 )
2014
12
Immunologic study and optimization of Salmonella delivery strains expressing adhesin and toxin antigens for protection against progressive atrophic rhinitis in a murine model. ( 25355999 )
2014
13
Complete Genome Sequence of Bordetella bronchiseptica S798, an Isolate from a Pig with Atrophic Rhinitis. ( 24831150 )
2014
14
New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet-rich plasma in five patients: Our Experience. ( 24938860 )
2014
15
Atrophic rhinitis. ( 23484896 )
2013
16
Acute Exacerbation of Chronic Rhinosinusitis (AECRS) with Orbital Complications in an Atrophic Rhinitis Patient: A Mere Co-incidence? ( 24551696 )
2013
17
Chronic rhinosinusitis in ex-lepromatous leprosy patients with atrophic rhinitis. ( 23398842 )
2013
18
Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis. ( 21717190 )
2012
19
Primary atrophic rhinitis: a clinical profile, microbiological and radiological study. ( 23762613 )
2012
20
Rhinoplasty in atrophic rhinitis. ( 23025225 )
2012
21
Interventions for atrophic rhinitis. ( 22336840 )
2012
22
Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin. ( 22411430 )
2012
23
Anhidrotic ectodermal dysplasia presenting as atrophic rhinitis. ( 22666945 )
2011
24
Rhinitis sicca, dry nose and atrophic rhinitis: a review of the literature. ( 20878413 )
2011
25
A report on a rare case of Klebsiella ozaenae causing atrophic rhinitis in the UK. ( 22669526 )
2011
26
Use of computer snout morphometry in atrophic rhinitis monitoring. ( 21498219 )
2011
27
Study of histopathological changes in primary atrophic rhinitis. ( 23724252 )
2011
28
A new technique for nasal stent fabrication for atrophic rhinitis: a clinical report. ( 21585589 )
2011
29
Primary atrophic rhinitis. ( 20869578 )
2010
30
Microbiological study of role of fungi in primary atrophic rhinitis. ( 18926001 )
2009
31
Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine. ( 19428902 )
2009
32
Hypohidrotic ectodermal dysplasia with atrophic rhinitis and nasal myiasis. ( 19616858 )
2009
33
Atrophic rhinitis vaccine composition triggers different serological profiles that do not correlate with protection. ( 18401954 )
2008
34
Novel treatment of atrophic rhinitis: early results. ( 18317788 )
2008
35
Chitosan microspheres containing Bordetella bronchiseptica antigens as novel vaccine against atrophic rhinitis in pigs. ( 18600065 )
2008
36
Prosthetic management of atrophic rhinitis. ( 23120587 )
2008
37
On the risk of carcinomatous change in atrophic rhinitis. ( 17156518 )
2007
38
Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. ( 17569762 )
2007
39
Rhinoplasty and young's operation in atrophic rhinitis. ( 23120345 )
2006
40
Hypohidrotic (Anhidrotic) Ectodermal dysplasia - A rare cause of childhood Atrophic Rhinitis". ( 23120289 )
2006
41
Immunogenicity and efficacy of three recombinant subunit Pasteurella multocida toxin vaccines against progressive atrophic rhinitis in pigs. ( 16122849 )
2006
42
Light and electron microscopic study of primary atrophic rhinitis mucosa. ( 17063751 )
2006
43
Interesting observations on Primary Atrophic Rhinitis. ( 23120308 )
2006
44
Pre and post-treatment histopathological changes in atrophic rhinitis. ( 16761739 )
2005
45
Pre-cancerous changes in the nasal mucosa of atrophic rhinitis: A preliminary report. ( 23120119 )
2005
46
Radiology quiz case 4: primary atrophic rhinitis, or ozena. ( 16103316 )
2005
47
Association of growth performance with atrophic rhinitis and pneumonia detected at slaughter in a conventional pig herd in Hungary. ( 16156124 )
2005
48
Atrophic rhinitis in a patient with anhidrotic ectodermal dysplasia. ( 16218520 )
2005
49
Development of a genetically modified nontoxigenic Pasteurella multocida toxin as a candidate for use in vaccines against progressive atrophic rhinitis in pigs. ( 15691045 )
2005
50
The aetiology and management of atrophic rhinitis. ( 16354334 )
2005

Variations for Atrophic Rhinitis

Expression for Atrophic Rhinitis

Search GEO for disease gene expression data for Atrophic Rhinitis.

Pathways for Atrophic Rhinitis

Pathways related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 CTSA IFI30

GO Terms for Atrophic Rhinitis

Cellular components related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 8.62 CTSA IFI30

Sources for Atrophic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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