OZENA
MCID: ATR003
MIFTS: 40

Atrophic Rhinitis (OZENA)

Categories: Respiratory diseases

Aliases & Classifications for Atrophic Rhinitis

MalaCards integrated aliases for Atrophic Rhinitis:

Name: Atrophic Rhinitis 12 15 17
Rhinitis, Atrophic 12 44 70
Rhinitis Sicca 12 70
Ozena 12 70
Dry Rhinitis 12
Ozaena 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4731
MeSH 44 D012222
SNOMED-CT 67 28111002
UMLS 70 C0030105 C0035459 C0339800

Summaries for Atrophic Rhinitis

Disease Ontology : 12 A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

MalaCards based summary : Atrophic Rhinitis, also known as rhinitis, atrophic, is related to rhinitis and actinobacillosis, and has symptoms including rhinorrhea An important gene associated with Atrophic Rhinitis is CTSA (Cathepsin A), and among its related pathways/superpathways are TRAF Pathway and Oxytocin signaling pathway. The drugs Immunoglobulins and Immunoglobulin E have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and tonsil, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Atrophic Rhinitis

Diseases related to Atrophic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 rhinitis 11.3
2 actinobacillosis 11.1
3 ectodermal dysplasia 10.3
4 myiasis 10.3
5 pneumonia 10.3
6 mongolian spot 10.2 NEU1 GNAQ
7 morquio syndrome 10.2 NEU1 CTSA
8 skin hemangioma 10.2 NEU1 CTSA
9 leprosy 3 10.2
10 pasteurellosis 10.2
11 hansen's disease 10.2
12 angiokeratoma 10.2 NEU1 CTSA
13 glycoproteinosis 10.2 NEU1 CTSA
14 ectodermal dysplasia 10b 10.2 EDARADD EDA
15 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.2 EDARADD EDA
16 bronchopneumonia 10.2
17 pleuropneumonia 10.2
18 iron metabolism disease 10.2
19 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.1 EDARADD EDA
20 gangliosidosis 10.1 NEU1 CTSA
21 anodontia 10.1 EDARADD EDA
22 hydrops fetalis, nonimmune 10.1 NEU1 CTSA
23 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.1 EDARADD EDA
24 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.1
25 deficiency anemia 10.1
26 bone resorption disease 10.1
27 rapidly involuting congenital hemangioma 10.1
28 osteomyelitis 10.1
29 bacterial infectious disease 10.1
30 anhidrosis 10.1
31 iron deficiency anemia 10.1
32 pericarditis 10.1
33 pharyngitis 10.1
34 hypotrichosis 10.1
35 dacryoadenitis 10.1
36 upper respiratory tract disease 10.1
37 dacryocystitis 10.1
38 pasteurella multocida infection 10.1
39 headache 10.0
40 sweat gland disease 9.9 EDARADD EDA
41 galactosialidosis 9.9 NEU1 CTSA
42 osteoporosis 9.9
43 chromosome 2q35 duplication syndrome 9.9
44 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
45 retinitis pigmentosa 9.9
46 allergic rhinitis 9.9
47 bone mineral density quantitative trait locus 8 9.9
48 bone mineral density quantitative trait locus 15 9.9
49 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.9
50 usher syndrome 9.9

Graphical network of the top 20 diseases related to Atrophic Rhinitis:



Diseases related to Atrophic Rhinitis

Symptoms & Phenotypes for Atrophic Rhinitis

UMLS symptoms related to Atrophic Rhinitis:


rhinorrhea

GenomeRNAi Phenotypes related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.4 SUCLG2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.4 ARHGEF1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.4 RHOA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 9.4 RHOA
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.4 ARHGEF25
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.4 ARHGEF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-21 9.4 RHOA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-45 9.4 ARHGEF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.4 RHOA
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.4 ARHGEF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 9.4 ARHGEF1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-96 9.4 ARHGEF1

MGI Mouse Phenotypes related to Atrophic Rhinitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.73 ARHGEF1 ARHGEF25 CTSA EDARADD GNAQ MDH2
2 craniofacial MP:0005382 9.7 CTSA EDARADD GNAQ MDH2 PLCB1 TNFSF11
3 respiratory system MP:0005388 9.1 CTSA EDARADD GNAQ NEU1 TNFSF11 WDPCP

Drugs & Therapeutics for Atrophic Rhinitis

Drugs for Atrophic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Immunoglobulin E Phase 3
3 Immunoglobulins, Intravenous Phase 3
4 Antibodies Phase 3
5 Adjuvants, Immunologic Phase 3
6 Immunologic Factors Phase 3
7 Broncho-Vaxom Phase 3
8
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
9 abobotulinumtoxinA Phase 1, Phase 2
10 Neurotransmitter Agents Phase 1, Phase 2
11 Cholinergic Agents Phase 1, Phase 2
12 Botulinum Toxins, Type A Phase 1, Phase 2
13 Botulinum Toxins Phase 1, Phase 2
14
Lidocaine Approved, Vet_approved 137-58-6 3676
15 Pharmaceutical Solutions
16 Calcium, Dietary
17
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect Of Polivalent Mechanical Bacterial Lysate On The Clinical Course Of Grass Pollen-Induced Allergic Rhinitis In Children Completed NCT04270552 Phase 3 Ismigen;Placebo
2 The Effect of Polyvalent Mechanical Bacterial Lysate on the Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis Completed NCT04637425 Phase 3 Ismigen;Placebo
3 Multicentre, Randomised, Double Blind, Placebo-controlled Study of the Efficacy and Safety of Broncho-Vaxom (OM 85 BV) in Children Suffering From Atopic Dermatitis Completed NCT03047954 Phase 3 Broncho-Vaxom;Placebo - Cap
4 The Effect of Immunostimulation With Polyvalent Mechanical Bacterial Lysate on Changes in the Concentration of iNKT Cells in Children With Allergic Rhinitis. Enrolling by invitation NCT04802616 Phase 3 Ismigen;Placebo
5 Prospective Case Series Evaluating Short and Long Term Benefits of the Use of Botox in the Treatment of Empty Nose Syndrome Terminated NCT00732680 Phase 1, Phase 2 Botulinum Toxin Type A
6 A Single-center, Non-randomized, Open, Single-arm Confirmatory Clinical Study to Evaluate the Safety and Efficacy of Platelet Rich Plasma Injection for Patients With Atrophic Rhinitis Completed NCT03112330
7 Evaluation Of Role Of Platelet Rich Plasma In Treatment Of Patients Suffering From Atrophic Rhinitis Not yet recruiting NCT04717960
8 Gore Tex Implants in the Treatment of Atrophic Rhinitis Suspended NCT00832403

Search NIH Clinical Center for Atrophic Rhinitis

Cochrane evidence based reviews: rhinitis, atrophic

Genetic Tests for Atrophic Rhinitis

Anatomical Context for Atrophic Rhinitis

MalaCards organs/tissues related to Atrophic Rhinitis:

40
Bone, Skin, Tonsil, Pituitary, Heart, Tongue

Publications for Atrophic Rhinitis

Articles related to Atrophic Rhinitis:

(show top 50) (show all 881)
# Title Authors PMID Year
1
Platelet-Rich Plasma Injection in Patients with Atrophic Rhinitis. 61
33561860 2021
2
Distinct Histopathology Characteristics in Empty Nose Syndrome. 61
32125703 2021
3
Comparative genomics of the Pasteurella multocida toxin. 61
33471631 2021
4
Production of Highly Active Recombinant Dermonecrotic Toxin of Bordetella Pertussis. 61
32942577 2020
5
Olfaction in Primary Atrophic Rhinitis and Effect of Treatment. 61
32885128 2020
6
Comparative genomic analysis of Bordetella bronchiseptica isolates from the lungs of pigs with porcine respiratory disease complex (PRDC). 61
32087347 2020
7
Middle Turbinate Seromucinous Hamartoma in a Patient With Primary Atrophic Rhinitis. 61
32579390 2020
8
Prevalence of virulence factor, antibiotic resistance, and serotype genes of Pasteurella multocida strains isolated from pigs in Vietnam. 61
32636585 2020
9
In Vivo Targets of Pasteurella Multocida Toxin. 61
32326543 2020
10
Complex rhinobronchial dystrophy and immunodeficiency: Chance association or exceptional congenital syndrome? 61
31734144 2020
11
Case Report: Nasal Myiasis in an Elderly Patient with Atrophic Rhinitis and Facial Sequelae of Leprosy. 61
31802737 2020
12
Characterization of a Unique Bordetella bronchiseptica vB_BbrP_BB8 Bacteriophage and Its Application as an Antibacterial Agent. 61
32093105 2020
13
Multi-Organ Abscesses and 5th Cervical Vertebra Bone Destruction Related with Klebsiella ozaenae Infection: A Case Report. 61
33281457 2020
14
Evaluation of the immunobiological effects of a regenerative far-infrared heating system in pigs. 61
31775188 2019
15
Atrophic Rhinitis. 61
31451401 2019
16
Role of α-Tocopherol Acetate on Nasal Respiratory Functions: Mucociliary Clearance and Rhinomanometric Evaluations in Primary Atrophic Rhinitis. 61
31578104 2019
17
Immunomodulating effect of a seaweed extract from Ulva armoricana in pig: Specific IgG and total IgA in colostrum, milk, and blood. 61
32734073 2019
18
Pasteurella multocida isolates associated with ovine pneumonia are toxigenic. 61
31030847 2019
19
Extranodal NK/T cell lymphoma, nasal type, with retrobulbar extraconal phlegmon and naso-oral fistula. 61
30852512 2019
20
Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. 61
30670313 2019
21
Characterization and comparison of strains of Pasteurella multocida associated with cases of progressive atrophic rhinitis and porcine pneumonia in Argentina. 61
31089314 2019
22
Current Understanding of the Acute Exacerbation of Chronic Rhinosinusitis. 61
31867289 2019
23
Pan-genomic approach shows insight of genetic divergence and pathogenic-adaptation of Pasteurella multocida. 61
29802996 2018
24
Pasteurella multocida inactivated with ferric chloride and adjuvanted with bacterial DNA is a potent and efficacious vaccine in Balb/c mice. 61
30016232 2018
25
Chronic Nonallergic Rhinitis. 61
30215894 2018
26
Involvement of Osteocytes in the Action of Pasteurella multocida Toxin. 61
30104531 2018
27
Evaluation of carbopol as an adjuvant on the effectiveness of progressive atrophic rhinitis vaccine. 61
29909135 2018
28
Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study. 61
30460908 2018
29
Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. 61
28669540 2018
30
Histopathological Findings in an Unclassifiable Case of Empty Nose Syndrome with Long-term Follow-up. 61
30042906 2018
31
Effect of a live attenuated vaccine against Lawsonia intracellularis in weaned and finishing pig settings in Finland. 61
29566718 2018
32
Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts. 61
29030011 2018
33
[Complications after endoscopic endonasal transsphenoidal removal of pituitary adenomas]. 61
30721224 2018
34
Field evaluation of piglet vaccination with a Mycoplasma hyopneumoniae bacterin as compared to a ready-to-use product including porcine circovirus 2 and M. hyopneumoniae in a conventional French farrow-to-finish farm. 61
29375890 2018
35
Capsular Polysaccharide Interferes with Biofilm Formation by Pasteurella multocida Serogroup A. 61
29162713 2017
36
Is submucosal fat injection effective in atrophic rhinitis? An experimental animal study. 61
28707085 2017
37
Antimicrobial susceptibility, serotypes and genotypes of Pasteurella multocida isolates associated with swine pneumonia in Taiwan. 61
28784694 2017
38
Mortality in Danish Swine herds: Spatio-temporal clusters and risk factors. 61
28903874 2017
39
The Myriad Properties of Pasteurella multocida Lipopolysaccharide. 61
28825691 2017
40
Surgical treatment of nasal septal perforations: SIR (Italian Society of Rhinology) experts opinion. 61
28162219 2017
41
Analyses and treatments of postoperative nasal complications after endonasal transsphenoidal resection of pituitary neoplasms. 61
28403108 2017
42
Role of Histopathology in Differentiating Primary Atrophic Rhinitis from Atrophic Stage of Rhinoscleroma. 61
28239581 2017
43
The First Siphoviridae Family Bacteriophages Infecting Bordetella bronchiseptica Isolated from Environment. 61
27628741 2017
44
Pasteurella multocida Toxin Triggers RANKL-Independent Osteoclastogenesis. 61
28289415 2017
45
Occurrence of Pasteurella multocida among pigs with respiratory disease in China between 2011 and 2015. 61
28078081 2017
46
Biofilm inhibitors targeting the outer membrane protein A of Pasteurella multocida in swine. 61
27892689 2017
47
Genome-Wide Analyses Reveal Genes Subject to Positive Selection in Pasteurella multocida. 61
28611758 2017
48
A novel quantitative real-time polymerase chain reaction method for detecting toxigenic Pasteurella multocida in nasal swabs from swine. 61
27903273 2016
49
Empty nose syndrome and atrophic rhinitis. 61
27613452 2016
50
Selective Membrane Redistribution and Depletion of Gαq-Protein by Pasteurella multocida Toxin. 61
27490568 2016

Variations for Atrophic Rhinitis

Expression for Atrophic Rhinitis

Search GEO for disease gene expression data for Atrophic Rhinitis.

Pathways for Atrophic Rhinitis

Pathways related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 TNFSF11 PLCB1 GNAQ EDA
2
Show member pathways
12.16 RHOA PLCB1 GNAQ ARHGEF1
3
Show member pathways
12.02 TRPM8 PLCB1 GNAQ
4 11.85 RHOA GNAQ ARHGEF1
5
Show member pathways
11.78 RHOA PLCB1 GNAQ
6 11.76 RHOA PLCB1 GNAQ
7 11.65 TNFSF11 EDARADD EDA
8
Show member pathways
11.46 TNFSF11 EDARADD EDA
9 11.35 RHOA PLCB1 GNAQ ARHGEF1
10 11.31 RHOA GNAQ ARHGEF1
11 11.1 RHOA ARHGEF25 ARHGEF1
12 11.05 TNFSF11 RHOA PLCB1 GNAQ ARHGEF1
13 11 PLCB1 GNAQ
14 10.96 RHOA PLCB1
15 10.92 TNFSF11 PLCB1 GNAQ
16
Show member pathways
10.7 PLCB1 GNAQ
17 10.55 PLCB1 GNAQ

GO Terms for Atrophic Rhinitis

Cellular components related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.77 XPNPEP2 WDPCP TRPM8 TNFSF11 RHOA PLCB1
2 extracellular exosome GO:0070062 9.7 XPNPEP2 RHOA PLCB1 NEU1 MDH2 GNAQ
3 plasma membrane GO:0005886 9.36 XPNPEP2 WDPCP TRPM8 TNFSF11 SUCLG2 RHOA

Biological processes related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.54 TNFSF11 RHOA EDA
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFSF11 EDARADD EDA
3 regulation of focal adhesion assembly GO:0051893 9.32 WDPCP RHOA
4 glutamate receptor signaling pathway GO:0007215 9.16 PLCB1 GNAQ
5 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 8.96 PLCB1 GNAQ
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 8.8 RHOA EDARADD EDA

Molecular functions related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 TNFSF11 EDA
2 Rho guanyl-nucleotide exchange factor activity GO:0005089 8.62 ARHGEF25 ARHGEF1

Sources for Atrophic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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