OZENA
MCID: ATR003
MIFTS: 33

Atrophic Rhinitis (OZENA)

Categories: Respiratory diseases

Aliases & Classifications for Atrophic Rhinitis

MalaCards integrated aliases for Atrophic Rhinitis:

Name: Atrophic Rhinitis 12 15 17
Rhinitis, Atrophic 12 43 71
Rhinitis Sicca 12 71
Ozena 12 71
Dry Rhinitis 12
Ozaena 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4731
MeSH 43 D012222
SNOMED-CT 67 28111002
UMLS 71 C0030105 C0035459 C0339800

Summaries for Atrophic Rhinitis

Disease Ontology : 12 A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

MalaCards based summary : Atrophic Rhinitis, also known as rhinitis, atrophic, is related to pasteurellosis and chronic rhinitis, and has symptoms including rhinorrhea An important gene associated with Atrophic Rhinitis is NEU1 (Neuraminidase 1), and among its related pathways/superpathways is TNFs bind their physiological receptors. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary.

Related Diseases for Atrophic Rhinitis

Diseases related to Atrophic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 pasteurellosis 30.5 NEU1 GUF1
2 chronic rhinitis 30.1 RHNO1 KIDINS220
3 actinobacillosis 11.4
4 rhinitis 11.3
5 neuraminidase deficiency 10.4 NEU1 CTSA
6 ectodermal dysplasia 10.4
7 galactosialidosis 10.4 NEU1 CTSA
8 morquio syndrome 10.4 NEU1 CTSA
9 skin hemangioma 10.3 NEU1 CTSA
10 meningitis 10.3
11 rhinosporidiosis 10.3 RHNO1 DCXR
12 parasitic ichthyosporea infectious disease 10.3 RHNO1 DCXR
13 myiasis 10.3
14 ethmoid sinusitis 10.3 RHNO1 DCXR
15 chronic frontal sinusitis 10.3 RHNO1 KIDINS220
16 excessive tearing 10.3 RHNO1 DCXR
17 maxillary sinus inverted papilloma 10.3 RHNO1 DCXR
18 chronic ethmoiditis 10.3 RHNO1 KIDINS220
19 glycoproteinosis 10.3 NEU1 CTSA
20 leprosy 3 10.3
21 pneumonia 10.3
22 hansen's disease 10.3
23 internal hordeolum 10.2 KIDINS220 DCXR
24 acute frontal sinusitis 10.2 RHNO1 DCXR
25 dacryocystocele 10.2 KIDINS220 DCXR
26 bronchopneumonia 10.2
27 pleuropneumonia 10.2
28 iron metabolism disease 10.2
29 chronic inflammation of lacrimal passage 10.2 KIDINS220 DCXR
30 headache 10.2
31 otitis media 10.2
32 acute cystitis 10.2
33 angiokeratoma 10.1 NEU1 CTSA
34 acute dacryocystitis 10.1 RHNO1 DCXR
35 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.1
36 deficiency anemia 10.1
37 bone resorption disease 10.1
38 osteomyelitis 10.1
39 bacterial infectious disease 10.1
40 anhidrosis 10.1
41 iron deficiency anemia 10.1
42 pericarditis 10.1
43 pharyngitis 10.1
44 hypotrichosis 10.1
45 dacryoadenitis 10.1
46 upper respiratory tract disease 10.1
47 dacryocystitis 10.1
48 pasteurella multocida infection 10.1
49 frontal sinusitis 10.1 RHNO1 KIDINS220 DCXR
50 gangliosidosis 10.1 NEU1 CTSA

Graphical network of the top 20 diseases related to Atrophic Rhinitis:



Diseases related to Atrophic Rhinitis

Symptoms & Phenotypes for Atrophic Rhinitis

UMLS symptoms related to Atrophic Rhinitis:


rhinorrhea

Drugs & Therapeutics for Atrophic Rhinitis

Drugs for Atrophic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 1, Phase 2
3 Neurotransmitter Agents Phase 1, Phase 2
4 Acetylcholine Release Inhibitors Phase 1, Phase 2
5 Neuromuscular Agents Phase 1, Phase 2
6 Cholinergic Agents Phase 1, Phase 2
7 Botulinum Toxins Phase 1, Phase 2
8 Botulinum Toxins, Type A Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Case Series Evaluating Short and Long Term Benefits of the Use of Botox in the Treatment of Empty Nose Syndrome Terminated NCT00732680 Phase 1, Phase 2 Botulinum Toxin Type A
2 A Single-center, Non-randomized, Open, Single-arm Confirmatory Clinical Study to Evaluate the Safety and Efficacy of Platelet Rich Plasma Injection for Patients With Atrophic Rhinitis Completed NCT03112330
3 A Randomized Controlled Trial Comparing Partial Resection Versus Preservation of the Middle Turbinate in Surgery for Chronic Rhinosinusitis With Polyposis (CRSwP) Completed NCT02855931
4 Gore Tex Implants in the Treatment of Atrophic Rhinitis Suspended NCT00832403
5 Da Vinci Transoral Robotic-assisted Surgery of Pituitary Gland Terminated NCT02743442
6 A Randomized Trial Comparing Two Surgical Techniques for Inferior Turbinate Reduction Withdrawn NCT00358267
7 Topical Antibiotic Use In Chronic Rhinosinusitis A Double-Blinded, Randomized, Placebo Controlled Study Withdrawn NCT00669799 gentamyacin;gentamyacin

Search NIH Clinical Center for Atrophic Rhinitis

Cochrane evidence based reviews: rhinitis, atrophic

Genetic Tests for Atrophic Rhinitis

Anatomical Context for Atrophic Rhinitis

MalaCards organs/tissues related to Atrophic Rhinitis:

40
Bone, Testes, Pituitary, Skin, Colon, Tonsil, Thyroid

Publications for Atrophic Rhinitis

Articles related to Atrophic Rhinitis:

(show top 50) (show all 867)
# Title Authors PMID Year
1
Case Report: Nasal Myiasis in an Elderly Patient with Atrophic Rhinitis and Facial Sequelae of Leprosy. 61
31802737 2020
2
Complex rhinobronchial dystrophy and immunodeficiency: Chance association or exceptional congenital syndrome? 61
31734144 2019
3
Atrophic Rhinitis. 61
31451401 2019
4
Evaluation of the immunobiological effects of a regenerative far-infrared heating system in pigs. 61
31775188 2019
5
Role of α-Tocopherol Acetate on Nasal Respiratory Functions: Mucociliary Clearance and Rhinomanometric Evaluations in Primary Atrophic Rhinitis. 61
31578104 2019
6
Pasteurella multocida isolates associated with ovine pneumonia are toxigenic. 61
31030847 2019
7
Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. 61
30670313 2019
8
Extranodal NK/T cell lymphoma, nasal type, with retrobulbar extraconal phlegmon and naso-oral fistula. 61
30852512 2019
9
Characterization and comparison of strains of Pasteurella multocida associated with cases of progressive atrophic rhinitis and porcine pneumonia in Argentina. 61
31089314 2019
10
Current Understanding of the Acute Exacerbation of Chronic Rhinosinusitis. 61
31867289 2019
11
Pan-genomic approach shows insight of genetic divergence and pathogenic-adaptation of Pasteurella multocida. 61
29802996 2018
12
Pasteurella multocida inactivated with ferric chloride and adjuvanted with bacterial DNA is a potent and efficacious vaccine in Balb/c mice. 61
30016232 2018
13
Chronic Nonallergic Rhinitis. 61
30215894 2018
14
Involvement of Osteocytes in the Action of Pasteurella multocida Toxin. 61
30104531 2018
15
Evaluation of carbopol as an adjuvant on the effectiveness of progressive atrophic rhinitis vaccine. 61
29909135 2018
16
Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study. 61
30460908 2018
17
Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. 61
28669540 2018
18
Histopathological Findings in an Unclassifiable Case of Empty Nose Syndrome with Long-term Follow-up. 61
30042906 2018
19
Effect of a live attenuated vaccine against Lawsonia intracellularis in weaned and finishing pig settings in Finland. 61
29566718 2018
20
Field evaluation of piglet vaccination with a Mycoplasma hyopneumoniae bacterin as compared to a ready-to-use product including porcine circovirus 2 and M. hyopneumoniae in a conventional French farrow-to-finish farm. 61
29375890 2018
21
[Complications after endoscopic endonasal transsphenoidal removal of pituitary adenomas]. 61
30721224 2018
22
Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts. 61
29030011 2018
23
Capsular Polysaccharide Interferes with Biofilm Formation by Pasteurella multocida Serogroup A. 61
29162713 2017
24
Is submucosal fat injection effective in atrophic rhinitis? An experimental animal study. 61
28707085 2017
25
Antimicrobial susceptibility, serotypes and genotypes of Pasteurella multocida isolates associated with swine pneumonia in Taiwan. 61
28784694 2017
26
Mortality in Danish Swine herds: Spatio-temporal clusters and risk factors. 61
28903874 2017
27
The Myriad Properties of Pasteurella multocida Lipopolysaccharide. 61
28825691 2017
28
Surgical treatment of nasal septal perforations: SIR (Italian Society of Rhinology) experts opinion. 61
28162219 2017
29
Analyses and treatments of postoperative nasal complications after endonasal transsphenoidal resection of pituitary neoplasms. 61
28403108 2017
30
Role of Histopathology in Differentiating Primary Atrophic Rhinitis from Atrophic Stage of Rhinoscleroma. 61
28239581 2017
31
The First Siphoviridae Family Bacteriophages Infecting Bordetella bronchiseptica Isolated from Environment. 61
27628741 2017
32
Biofilm inhibitors targeting the outer membrane protein A of Pasteurella multocida in swine. 61
27892689 2017
33
Occurrence of Pasteurella multocida among pigs with respiratory disease in China between 2011 and 2015. 61
28078081 2017
34
Pasteurella multocida Toxin Triggers RANKL-Independent Osteoclastogenesis. 61
28289415 2017
35
Genome-Wide Analyses Reveal Genes Subject to Positive Selection in Pasteurella multocida. 61
28611758 2017
36
A novel quantitative real-time polymerase chain reaction method for detecting toxigenic Pasteurella multocida in nasal swabs from swine. 61
27903273 2016
37
Empty nose syndrome and atrophic rhinitis. 61
27613452 2016
38
Selective Membrane Redistribution and Depletion of Gαq-Protein by Pasteurella multocida Toxin. 61
27490568 2016
39
Ozena in Immigrants of Differing Backgrounds. 61
27114295 2016
40
Anti-inflammatory and analgesic effects of Bi-yuan-ling granules. 61
27376820 2016
41
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma. 61
26940398 2016
42
Occurence of Bordetella bronchiseptica in domestic cats with upper respiratory tract infections. 61
27487509 2016
43
Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22. 61
26711033 2016
44
Sinonasal aspergillosis in a British Shorthair cat in the UK. 61
28491427 2016
45
Virulence genes and antimicrobial resistance of Pasteurella multocida isolated from poultry and swine. 61
26887247 2016
46
Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation. 61
26369790 2015
47
The clinical efficacy of surgical interventions for empty nose syndrome: A systematic review. 61
25647010 2015
48
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. 61
26163236 2015
49
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. 61
29021044 2015
50
[Submucosal Partial-turbinectomy (SPT) Preceding an Endoscopic Sinus Surgery (ESS) Procedure]. 61
26427129 2015

Variations for Atrophic Rhinitis

Expression for Atrophic Rhinitis

Search GEO for disease gene expression data for Atrophic Rhinitis.

Pathways for Atrophic Rhinitis

Pathways related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.1 TNFSF11 EDARADD

GO Terms for Atrophic Rhinitis

Cellular components related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 XPNPEP2 SEC14L2 RHOA NEU1 MDH2 DCXR

Sources for Atrophic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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