OZENA
MCID: ATR003
MIFTS: 33

Atrophic Rhinitis (OZENA)

Categories: Respiratory diseases

Aliases & Classifications for Atrophic Rhinitis

MalaCards integrated aliases for Atrophic Rhinitis:

Name: Atrophic Rhinitis 12 15 17
Rhinitis, Atrophic 12 44 72
Rhinitis Sicca 12 72
Ozena 12 72
Dry Rhinitis 12
Ozaena 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4731
MeSH 44 D012222
SNOMED-CT 68 28111002
UMLS 72 C0030105 C0035459 C0339800

Summaries for Atrophic Rhinitis

Disease Ontology : 12 A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

MalaCards based summary : Atrophic Rhinitis, also known as rhinitis, atrophic, is related to actinobacillosis and rhinitis, and has symptoms including rhinorrhea An important gene associated with Atrophic Rhinitis is XPNPEP2 (X-Prolyl Aminopeptidase 2), and among its related pathways/superpathways is MHC class II antigen presentation. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary.

Related Diseases for Atrophic Rhinitis

Diseases related to Atrophic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 actinobacillosis 11.4
2 rhinitis 11.3
3 ectodermal dysplasia 10.4
4 meningitis 10.3
5 pasteurellosis 10.3
6 myiasis 10.3
7 pneumonia 10.3
8 leprosy 3 10.2
9 bronchopneumonia 10.2
10 pleuropneumonia 10.2
11 iron metabolism disease 10.2
12 hansen's disease 10.2
13 headache 10.2
14 otitis media 10.2
15 acute cystitis 10.2
16 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.1
17 deficiency anemia 10.1
18 bone resorption disease 10.1
19 osteomyelitis 10.1
20 bacterial infectious disease 10.1
21 anhidrosis 10.1
22 iron deficiency anemia 10.1
23 pericarditis 10.1
24 pharyngitis 10.1
25 hypotrichosis 10.1
26 dacryoadenitis 10.1
27 upper respiratory tract disease 10.1
28 dacryocystitis 10.1
29 pasteurella multocida infection 10.1
30 autoimmune disease 10.0
31 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.0
32 ichthyosis vulgaris 10.0
33 spinal arachnoiditis 10.0
34 nasopharyngitis 10.0
35 keratomalacia 10.0
36 arachnoiditis 10.0
37 otosclerosis 10.0
38 ichthyosis 10.0
39 pulmonary tuberculosis 10.0
40 skin disease 10.0
41 cerebrospinal fluid leak 10.0
42 klebsiella infection 10.0
43 depression 10.0
44 fibrosis of extraocular muscles, congenital, 1 10.0
45 keratitis, hereditary 10.0
46 tracheopathia osteoplastica 10.0
47 cystic fibrosis 10.0
48 nasopharyngeal carcinoma 10.0
49 melioidosis 10.0
50 pollen allergy 10.0

Graphical network of the top 20 diseases related to Atrophic Rhinitis:



Diseases related to Atrophic Rhinitis

Symptoms & Phenotypes for Atrophic Rhinitis

UMLS symptoms related to Atrophic Rhinitis:


rhinorrhea

Drugs & Therapeutics for Atrophic Rhinitis

Drugs for Atrophic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 1, Phase 2
3 Neurotransmitter Agents Phase 1, Phase 2
4 Neuromuscular Agents Phase 1, Phase 2
5 Cholinergic Agents Phase 1, Phase 2
6 Peripheral Nervous System Agents Phase 1, Phase 2
7 Acetylcholine Release Inhibitors Phase 1, Phase 2
8 Botulinum Toxins Phase 1, Phase 2
9 Botulinum Toxins, Type A Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Case Series Evaluating Short and Long Term Benefits of the Use of Botox in the Treatment of Empty Nose Syndrome Terminated NCT00732680 Phase 1, Phase 2 Botulinum Toxin Type A
2 A Single-center, Non-randomized, Open, Single-arm Confirmatory Clinical Study to Evaluate the Safety and Efficacy of Platelet Rich Plasma Injection for Patients With Atrophic Rhinitis Completed NCT03112330
3 A Randomized Controlled Trial Comparing Partial Resection Versus Preservation of the Middle Turbinate in Surgery for Chronic Rhinosinusitis With Polyposis (CRSwP) Completed NCT02855931
4 Gore Tex Implants in the Treatment of Atrophic Rhinitis Suspended NCT00832403
5 Da Vinci Transoral Robotic-assisted Surgery of Pituitary Gland Terminated NCT02743442
6 A Randomized Trial Comparing Two Surgical Techniques for Inferior Turbinate Reduction Withdrawn NCT00358267
7 Topical Antibiotic Use In Chronic Rhinosinusitis A Double-Blinded, Randomized, Placebo Controlled Study Withdrawn NCT00669799 gentamyacin;gentamyacin

Search NIH Clinical Center for Atrophic Rhinitis

Cochrane evidence based reviews: rhinitis, atrophic

Genetic Tests for Atrophic Rhinitis

Anatomical Context for Atrophic Rhinitis

MalaCards organs/tissues related to Atrophic Rhinitis:

41
Bone, Testes, Pituitary, Colon, Tonsil, Thyroid, Liver

Publications for Atrophic Rhinitis

Articles related to Atrophic Rhinitis:

(show top 50) (show all 861)
# Title Authors PMID Year
1
Pasteurella multocida isolates associated with ovine pneumonia are toxigenic. 38
31030847 2019
2
Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. 38
30670313 2019
3
Extranodal NK/T cell lymphoma, nasal type, with retrobulbar extraconal phlegmon and naso-oral fistula. 38
30852512 2019
4
Characterization and comparison of strains of Pasteurella multocida associated with cases of progressive atrophic rhinitis and porcine pneumonia in Argentina. 38
31089314 2019
5
Pan-genomic approach shows insight of genetic divergence and pathogenic-adaptation of Pasteurella multocida. 38
29802996 2018
6
Pasteurella multocida inactivated with ferric chloride and adjuvanted with bacterial DNA is a potent and efficacious vaccine in Balb/c mice. 38
30016232 2018
7
Chronic Nonallergic Rhinitis. 38
30215894 2018
8
Involvement of Osteocytes in the Action of Pasteurella multocida Toxin. 38
30104531 2018
9
Evaluation of carbopol as an adjuvant on the effectiveness of progressive atrophic rhinitis vaccine. 38
29909135 2018
10
Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study. 38
30460908 2018
11
Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. 38
28669540 2018
12
Histopathological Findings in an Unclassifiable Case of Empty Nose Syndrome with Long-term Follow-up. 38
30042906 2018
13
Effect of a live attenuated vaccine against Lawsonia intracellularis in weaned and finishing pig settings in Finland. 38
29566718 2018
14
Field evaluation of piglet vaccination with a Mycoplasma hyopneumoniae bacterin as compared to a ready-to-use product including porcine circovirus 2 and M. hyopneumoniae in a conventional French farrow-to-finish farm. 38
29375890 2018
15
[Complications after endoscopic endonasal transsphenoidal removal of pituitary adenomas]. 38
30721224 2018
16
Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts. 38
29030011 2018
17
Capsular Polysaccharide Interferes with Biofilm Formation by Pasteurella multocida Serogroup A. 38
29162713 2017
18
Is submucosal fat injection effective in atrophic rhinitis? An experimental animal study. 38
28707085 2017
19
Antimicrobial susceptibility, serotypes and genotypes of Pasteurella multocida isolates associated with swine pneumonia in Taiwan. 38
28784694 2017
20
Mortality in Danish Swine herds: Spatio-temporal clusters and risk factors. 38
28903874 2017
21
The Myriad Properties of Pasteurella multocida Lipopolysaccharide. 38
28825691 2017
22
Surgical treatment of nasal septal perforations: SIR (Italian Society of Rhinology) experts opinion. 38
28162219 2017
23
Analyses and treatments of postoperative nasal complications after endonasal transsphenoidal resection of pituitary neoplasms. 38
28403108 2017
24
Role of Histopathology in Differentiating Primary Atrophic Rhinitis from Atrophic Stage of Rhinoscleroma. 38
28239581 2017
25
The First Siphoviridae Family Bacteriophages Infecting Bordetella bronchiseptica Isolated from Environment. 38
27628741 2017
26
Biofilm inhibitors targeting the outer membrane protein A of Pasteurella multocida in swine. 38
27892689 2017
27
Occurrence of Pasteurella multocida among pigs with respiratory disease in China between 2011 and 2015. 38
28078081 2017
28
Pasteurella multocida Toxin Triggers RANKL-Independent Osteoclastogenesis. 38
28289415 2017
29
Genome-Wide Analyses Reveal Genes Subject to Positive Selection in Pasteurella multocida. 38
28611758 2017
30
A novel quantitative real-time polymerase chain reaction method for detecting toxigenic Pasteurella multocida in nasal swabs from swine. 38
27903273 2016
31
Empty nose syndrome and atrophic rhinitis. 38
27613452 2016
32
Selective Membrane Redistribution and Depletion of Gαq-Protein by Pasteurella multocida Toxin. 38
27490568 2016
33
Ozena in Immigrants of Differing Backgrounds. 38
27114295 2016
34
Anti-inflammatory and analgesic effects of Bi-yuan-ling granules. 38
27376820 2016
35
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma. 38
26940398 2016
36
Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22. 38
26711033 2016
37
Occurence of Bordetella bronchiseptica in domestic cats with upper respiratory tract infections. 38
27487509 2016
38
Sinonasal aspergillosis in a British Shorthair cat in the UK. 38
28491427 2016
39
Virulence genes and antimicrobial resistance of Pasteurella multocida isolated from poultry and swine. 38
26887247 2016
40
Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation. 38
26369790 2015
41
The clinical efficacy of surgical interventions for empty nose syndrome: A systematic review. 38
25647010 2015
42
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. 38
26163236 2015
43
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. 38
29021044 2015
44
Repair of nasal septal perforation using middle turbinate flap (monopedicled superiory based bone included conchal flap): a new unilateral middle turbinate mucosal flap technique. 38
25190253 2015
45
[Submucosal Partial-turbinectomy (SPT) Preceding an Endoscopic Sinus Surgery (ESS) Procedure]. 38
26427129 2015
46
Surfactant protein a expression in chronic rhinosinusitis and atrophic rhinitis. 38
25992168 2015
47
Atrophic rhinitis caused by Cedecea davisae with accompanying mucocele. 38
26211869 2015
48
Polymorphisms influencing expression of dermonecrotic toxin in Bordetella bronchiseptica. 38
25642712 2015
49
[Squamous epithelium in the nasal cytology]. 38
27024949 2015
50
Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin. 38
25389180 2014

Variations for Atrophic Rhinitis

Expression for Atrophic Rhinitis

Search GEO for disease gene expression data for Atrophic Rhinitis.

Pathways for Atrophic Rhinitis

Pathways related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 IFI30 CTSA

GO Terms for Atrophic Rhinitis

Cellular components related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 8.62 IFI30 CTSA

Biological processes related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 base-excision repair GO:0006284 8.62 RPA1 MPG

Molecular functions related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 8.62 RPA1 MPG

Sources for Atrophic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....