PDD
MCID: ATY003
MIFTS: 31

Atypical Autism (PDD)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Atypical Autism

MalaCards integrated aliases for Atypical Autism:

Name: Atypical Autism 12 58 15 71 32
Pdd 12

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0060042
ICD10 32 F84.1
ICD10 via Orphanet 33 F84.1
UMLS via Orphanet 72 C0338986
Orphanet 58 ORPHA199627
UMLS 71 C0338986

Summaries for Atypical Autism

Disease Ontology : 12 An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism.

MalaCards based summary : Atypical Autism, also known as pdd, is related to childhood disintegrative disease and attention deficit-hyperactivity disorder. An important gene associated with Atypical Autism is TOR3A (Torsin Family 3 Member A), and among its related pathways/superpathways are Neuroscience and Protein-protein interactions at synapses. Affiliated tissues include temporal lobe.

Related Diseases for Atypical Autism

Diseases related to Atypical Autism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 childhood disintegrative disease 31.6 TOR3A SHANK2 NLGN4X NLGN3 MECP2 ATG4C
2 attention deficit-hyperactivity disorder 29.8 SNCA NLGN4X MECP2 FMR1 BCHE
3 fragile x syndrome 28.8 TOR3A SHANK2 NLGN4X NLGN3 MECP2 FMR1
4 autism spectrum disorder 28.8 SNCA SHANK2 NLGN4X NLGN3 MECP2 FMR1
5 asperger syndrome 27.9 TOR3A SHANK2 NLGN4X NLGN3 MECP2 IQCB1
6 pervasive developmental disorder 27.6 TOR3A SNCA SHANK2 NLGN4X NLGN3 MECP2
7 camurati-engelmann disease 11.6
8 autism x-linked 1 11.2
9 autism x-linked 2 11.2
10 autism x-linked 3 11.2
11 autism x-linked 4 11.2
12 autism x-linked 5 11.2
13 autism x-linked 6 11.2
14 autism 8 11.2
15 autism 3 11.2
16 autism 7 11.2
17 autism 11 11.2
18 autism 12 11.2
19 autism 13 11.2
20 autism 9 11.2
21 autism 10 11.2
22 autism 15 11.2
23 autism 16 11.2
24 autism 17 11.2
25 autism 18 11.2
26 dysthymic disorder 11.1
27 mental retardation, autosomal dominant 26 10.6
28 rare pervasive developmental disorder 10.6
29 dementia 10.4
30 bladder cancer 10.4
31 autism 10.4
32 valproate embryopathy 10.3 NLGN3 MECP2
33 parkinson disease, late-onset 10.2
34 pitt-hopkins-like syndrome 1 10.2 NLGN4X NLGN3 MECP2
35 potocki-lupski syndrome 10.2 NLGN4X NLGN3 MECP2
36 alacrima, achalasia, and mental retardation syndrome 10.2
37 in situ carcinoma 10.2
38 akinetic mutism 10.1 SNCA BCHE
39 alcohol-related neurodevelopmental disorder 10.1 PAF1 MECP2
40 specific language impairment 10.1 TOR3A NLGN4X IQCB1
41 rem sleep behavior disorder 10.0 SNCA BCHE ATG4C
42 kaufman oculocerebrofacial syndrome 10.0 NLGN4X NLGN3 FMR1
43 lubs x-linked mental retardation syndrome 10.0 NLGN3 MECP2 FMR1
44 alzheimer disease 10.0
45 multiple sclerosis 10.0
46 multiple system atrophy 1 10.0
47 prader-willi syndrome 10.0
48 dowling-degos disease 1 10.0
49 arachnoid cysts, intracranial 10.0
50 supranuclear palsy, progressive, 1 10.0

Graphical network of the top 20 diseases related to Atypical Autism:



Diseases related to Atypical Autism

Symptoms & Phenotypes for Atypical Autism

Drugs & Therapeutics for Atypical Autism

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical and Genetic Study of Autism Spectrum Disorder Unknown status NCT00494754
2 Clinical Evaluation of Integrative Practices Units Infant and Child Care for Unit Children With Typical or Atypical Autism (AUTISM) Completed NCT02154828
3 MR Scanning of Very Young Children With Severe Developmental Disorders (Autistic Spectrum Disorders and/or Mental Retardation and/or Language Disorders) Completed NCT00156221

Search NIH Clinical Center for Atypical Autism

Genetic Tests for Atypical Autism

Anatomical Context for Atypical Autism

MalaCards organs/tissues related to Atypical Autism:

40
Temporal Lobe

Publications for Atypical Autism

Articles related to Atypical Autism:

(show top 50) (show all 111)
# Title Authors PMID Year
1
Whole genome investigation of an atypical autism case identifies a novel ANOS1 mutation with subsequent diagnosis of Kallmann syndrome. 61
32382505 2020
2
Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors. 61
32006358 2020
3
A 22q13.33 duplication harbouring the SHANK3 gene: does it cause neuropsychiatric disorders? 61
31678916 2019
4
[The diagnostics of autism spectrum disorder in children, adolescents and adults: Overview of the key questions and main results of the first part of the German AWMF-S3 - clinical guideline]. 61
30326807 2019
5
Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years - Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014. 61
30973853 2019
6
Complementary and alternative medicine use in adults with autism spectrum disorder in Germany: results from a multi-center survey. 61
30709386 2019
7
Pathways to a diagnosis of autism spectrum disorder in Germany: a survey of parents. 61
30949235 2019
8
Gait in children with infantile/atypical autism: Age-dependent decrease in gait variability and associations with motor skills. 61
30482681 2019
9
Adaptive trajectories and early risk factors in the autism spectrum: A 15-year prospective study. 61
30270526 2018
10
Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012. 61
30439868 2018
11
A case of nephrogenic syndrome of inappropriate antidiuresis caused by carbamazepine. 61
29282644 2018
12
Psychosis in a Child with Atypical Autism: A Case Report and a Brief Review of the Association of Psychosis and Autism. 61
29707425 2018
13
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. 61
29701730 2018
14
Serum Cytokine and Growth Factor Levels in Children with Autism Spectrum Disorder. 61
29705814 2018
15
Effectiveness of clozapine for the treatment of psychosis and disruptive behaviour in a child with Atypical Autism: A case report and a brief review of the evidence. 61
28704788 2017
16
Assessment of serum trace elements and electrolytes in children with childhood and atypical autism. 61
27707611 2017
17
Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink. 61
28595786 2017
18
Atypical autism in a boy with double duplication of 22q11.2: implications of increasing dosage. 61
29263838 2017
19
Kynurenine Pathway in Autism Spectrum Disorders in Children. 61
29694960 2017
20
Arteriovenous Malformation in a Youth with Atypical Autism Symptoms. 61
28989994 2017
21
Cytokine Profile in Autism Spectrum Disorders in Children. 61
27730473 2017
22
Experiences of diagnosing autism spectrum disorder: A survey of professionals in the United Kingdom. 61
26681687 2016
23
Clinical trial of modulatory effects of oxytocin treatment on higher-order social cognition in autism spectrum disorder: a randomized, placebo-controlled, double-blind and crossover trial. 61
27655235 2016
24
SYMPTOM PRESENTATIONS AND CLASSIFICATION OF AUTISM SPECTRUM DISORDER IN EARLY CHILDHOOD: APPLICATION TO THE DIAGNOSTIC CLASSIFICATION OF MENTAL HEALTH AND DEVELOPMENTAL DISORDERS OF INFANCY AND EARLY CHILDHOOD (DC:0-5). 61
27556740 2016
25
Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years--Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012. 61
27031587 2016
26
Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature. 61
27606025 2016
27
[Schooling of patients exhibiting Autism Spectrum Disorders without mental retardation]. 61
26358485 2015
28
Incontinence in children with autism spectrum disorder. 61
26052001 2015
29
Psychiatric comorbidity and cognitive profile in children with narcolepsy with or without association to the H1N1 influenza vaccination. 61
25325473 2015
30
[On the problem of psychological (psychometric) diagnosis of intelligence in children with developmental disorders]. 61
26356276 2015
31
Time trends over 16 years in incidence-rates of autism spectrum disorders across the lifespan based on nationwide Danish register data. 61
24554161 2014
32
Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. 61
24670961 2014
33
Autism and developmental profiles in preschoolers: stability and change over time. 61
24237479 2014
34
Single gene microdeletions and microduplication of 3p26.3 in three unrelated families: CNTN6 as a new candidate gene for intellectual disability. 61
25606055 2014
35
Autism in community pre-schoolers: developmental profiles. 61
23816626 2013
36
Application of custom-designed oligonucleotide array CGH in 145 patients with autistic spectrum disorders. 61
23032108 2013
37
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. 61
23613074 2013
38
Delineating the profile of autism spectrum disorder characteristics in Cornelia de Lange and Fragile X syndromes. 61
23301903 2013
39
The frequency and risk factors of allergy and asthma in children with autism--case-control study. 61
24741916 2013
40
Autism in the Faroe Islands: diagnostic stability from childhood to early adult life. 61
23476144 2013
41
Diseases of the gastrointestinal tract in individuals diagnosed as children with atypical autism: a Danish register study based on hospital diagnoses. 61
22987890 2013
42
Autism and autistic spectrum disorders in the context of new DSM-V classification, and clinical and epidemiological data. 61
22650115 2012
43
Children with Usher syndrome: mental and behavioral disorders. 61
22449032 2012
44
Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. 61
22456193 2012
45
[Autism spectrum disorders in children and adolescents]. 61
22937604 2012
46
Diagnosing autism spectrum disorders in primary care. 61
22235552 2011
47
Characteristics of autism spectrum disorders in a sample of egyptian and saudi patients: transcultural cross sectional study. 61
22051160 2011
48
der(4)t(Y;4): Three-generation transmission and sperm meiotic segregation analysis. 61
21465656 2011
49
Epilepsy and other central nervous system diseases in atypical autism: a case control study. 61
21207076 2011
50
Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. 61
21183371 2011

Variations for Atypical Autism

Expression for Atypical Autism

Search GEO for disease gene expression data for Atypical Autism.

Pathways for Atypical Autism

Pathways related to Atypical Autism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SNCA SHANK2 MECP2 FMR1
2
Show member pathways
11.25 SHANK2 NLGN4X NLGN3

GO Terms for Atypical Autism

Cellular components related to Atypical Autism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.85 SNCA SHANK2 PAF1 NLGN4X NLGN3 FMR1
2 synapse GO:0045202 9.8 SNCA SHANK2 NLGN4X NLGN3 MECP2 FMR1
3 postsynapse GO:0098794 9.58 NLGN3 MECP2 FMR1
4 spanning component of membrane GO:0089717 9.26 NLGN4X NLGN3
5 presynapse GO:0098793 9.26 SNCA NLGN4X NLGN3 FMR1
6 asymmetric, glutamatergic, excitatory synapse GO:0098985 9.16 NLGN4X NLGN3
7 symmetric, GABA-ergic, inhibitory synapse GO:0098983 8.62 NLGN4X NLGN3

Biological processes related to Atypical Autism according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.83 SNCA NLGN4X NLGN3 MECP2
2 synapse assembly GO:0007416 9.63 SHANK2 NLGN3 MECP2
3 excitatory postsynaptic potential GO:0060079 9.61 SNCA NLGN3 MECP2
4 positive regulation of excitatory postsynaptic potential GO:2000463 9.59 SHANK2 NLGN3
5 positive regulation of dendritic spine development GO:0060999 9.58 SHANK2 FMR1
6 regulation of AMPA receptor activity GO:2000311 9.58 SHANK2 NLGN3
7 synapse organization GO:0050808 9.58 SNCA NLGN4X NLGN3
8 regulation of neurotransmitter secretion GO:0046928 9.57 SNCA FMR1
9 neuron cell-cell adhesion GO:0007158 9.56 NLGN4X NLGN3
10 presynapse assembly GO:0099054 9.55 NLGN4X NLGN3
11 regulation of respiratory gaseous exchange by neurological system process GO:0002087 9.54 NLGN3 MECP2
12 synaptic vesicle endocytosis GO:0048488 9.54 SNCA NLGN4X NLGN3
13 presynaptic membrane assembly GO:0097105 9.51 NLGN4X NLGN3
14 adult behavior GO:0030534 9.5 SHANK2 NLGN4X NLGN3
15 negative regulation of excitatory postsynaptic potential GO:0090394 9.49 NLGN4X NLGN3
16 postsynaptic membrane assembly GO:0097104 9.48 NLGN4X NLGN3
17 social behavior GO:0035176 9.46 SHANK2 NLGN4X NLGN3 MECP2
18 vocalization behavior GO:0071625 9.43 SHANK2 NLGN4X NLGN3
19 long-term synaptic potentiation GO:0060291 9.26 SNCA SHANK2 NLGN3 MECP2
20 learning GO:0007612 9.02 SHANK2 NLGN4X NLGN3 MECP2 BCHE

Molecular functions related to Atypical Autism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein complex binding GO:0070840 9.16 SNCA FMR1
2 neurexin family protein binding GO:0042043 8.96 NLGN4X NLGN3
3 siRNA binding GO:0035197 8.62 MECP2 FMR1

Sources for Atypical Autism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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