MCID: ATY003
MIFTS: 28

Atypical Autism

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Atypical Autism

MalaCards integrated aliases for Atypical Autism:

Name: Atypical Autism 12 59 15 73
Pdd 12

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0060042
Orphanet 59 ORPHA199627
ICD10 via Orphanet 34 F84.1
UMLS via Orphanet 74 C0338986
ICD10 33 F84.1
UMLS 73 C0338986

Summaries for Atypical Autism

Disease Ontology : 12 An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism.

MalaCards based summary : Atypical Autism, also known as pdd, is related to pervasive developmental disorder and asperger syndrome. An important gene associated with Atypical Autism is PDP1 (Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1). Affiliated tissues include temporal lobe, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Atypical Autism

Diseases related to Atypical Autism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 pervasive developmental disorder 30.6 NLGN3 NLGN4X OXTR
2 asperger syndrome 28.2 NLGN3 NLGN4X OXTR
3 camurati-engelmann disease 11.3
4 mental retardation, autosomal dominant 26 10.3
5 autism 10.2
6 tuberous sclerosis 9.7
7 neurofibromatosis, type i 9.6
8 neurofibromatosis, type iv, of riccardi 9.6
9 arteriovenous malformation 9.6
10 epilepsy 9.6
11 central nervous system disease 9.6
12 nervous system disease 9.6
13 ring chromosome 17 9.6
14 autism spectrum disorder 8.7 NLGN3 NLGN4X OXTR

Graphical network of the top 20 diseases related to Atypical Autism:



Diseases related to Atypical Autism

Symptoms & Phenotypes for Atypical Autism

GenomeRNAi Phenotypes related to Atypical Autism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.28 ARHGAP24
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.28 ARHGAP24 ATG4C RAB11FIP5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.28 RAB11FIP5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.28 ATG4C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.28 ATG4C
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.28 ATG4C RAB11FIP5

Drugs & Therapeutics for Atypical Autism

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of Integrative Practices Units Infant and Child Care for Unit Children With Typical or Atypical Autism (AUTISM) Completed NCT02154828
2 Cognitive Behavioural Therapy (CBT) and Recreational Activity for Autism Spectrum Disorders (ASD) Completed NCT01655173 Not Applicable
3 MR Scanning of Very Young Children With Severe Developmental Disorders Completed NCT00156221

Search NIH Clinical Center for Atypical Autism

Genetic Tests for Atypical Autism

Anatomical Context for Atypical Autism

MalaCards organs/tissues related to Atypical Autism:

41
Temporal Lobe

Publications for Atypical Autism

Articles related to Atypical Autism:

(show all 17)
# Title Authors Year
1
Psychosis in a Child with Atypical Autism: A Case Report and a Brief Review of the Association of Psychosis and Autism. ( 29707425 )
2018
2
Effectiveness of clozapine for the treatment of psychosis and disruptive behaviour in a child with Atypical Autism: A case report and a brief review of the evidence. ( 28704788 )
2017
3
Arteriovenous Malformation in a Youth with Atypical Autism Symptoms. ( 28989994 )
2017
4
Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink. ( 28595786 )
2017
5
Atypical autism in a boy with double duplication of 22q11.2: implications of increasing dosage. ( 29263838 )
2017
6
Assessment of serum trace elements and electrolytes in children with childhood and atypical autism. ( 27707611 )
2016
7
Diseases of the gastrointestinal tract in individuals diagnosed as children with atypical autism: a Danish register study based on hospital diagnoses. ( 22987890 )
2013
8
Epilepsy and other central nervous system diseases in atypical autism: a case control study. ( 21207076 )
2011
9
Autism Spectrum Conditions. FAQs on Autism, Asperger Syndrome and Atypical Autism answered by International Experts. ( 21919953 )
2011
10
Psychiatric disorders in adults diagnosed as children with atypical autism. A case control study. ( 17768593 )
2008
11
A girl with neurofibromatosis type 1, atypical autism and mosaic ring chromosome 17. ( 17163520 )
2007
12
Comparison of high-functioning atypical autism and childhood autism by Childhood Autism Rating Scale-Tokyo version. ( 15009830 )
2004
13
Association of tuberous sclerosis of temporal lobes with autism and atypical autism. ( 9033466 )
1997
14
A comparative study of Asperger syndrome with high-functioning atypical autism. ( 9141143 )
1997
15
Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. ( 9106540 )
1997
16
Brief report: atypical autism and tuberous sclerosis in a sibling pair. ( 7592253 )
1995
17
Use of sulpiride in a case of atypical autism. ( 3372456 )
1988

Variations for Atypical Autism

Expression for Atypical Autism

Search GEO for disease gene expression data for Atypical Autism.

Pathways for Atypical Autism

GO Terms for Atypical Autism

Cellular components related to Atypical Autism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory synapse GO:0060076 9.26 NLGN3 NLGN4X
2 spanning component of membrane GO:0089717 9.16 NLGN3 NLGN4X
3 asymmetric, glutamatergic, excitatory synapse GO:0098985 8.96 NLGN3 NLGN4X
4 symmetric, GABA-ergic, inhibitory synapse GO:0098983 8.62 NLGN3 NLGN4X

Biological processes related to Atypical Autism according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 learning GO:0007612 9.54 NLGN3 NLGN4X
2 positive regulation of synapse assembly GO:0051965 9.52 NLGN3 OXTR
3 synapse organization GO:0050808 9.51 NLGN3 NLGN4X
4 modulation of chemical synaptic transmission GO:0050804 9.49 NLGN3 NLGN4X
5 adult behavior GO:0030534 9.48 NLGN3 NLGN4X
6 synaptic vesicle endocytosis GO:0048488 9.46 NLGN3 NLGN4X
7 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.43 NLGN3 OXTR
8 neuron cell-cell adhesion GO:0007158 9.4 NLGN3 NLGN4X
9 vocalization behavior GO:0071625 9.37 NLGN3 NLGN4X
10 presynaptic membrane assembly GO:0097105 9.32 NLGN3 NLGN4X
11 presynapse assembly GO:0099054 9.26 NLGN3 NLGN4X
12 negative regulation of excitatory postsynaptic potential GO:0090394 9.16 NLGN3 NLGN4X
13 postsynaptic membrane assembly GO:0097104 8.96 NLGN3 NLGN4X
14 social behavior GO:0035176 8.8 NLGN3 NLGN4X OXTR

Molecular functions related to Atypical Autism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 9.26 NLGN3 NLGN4X
2 scaffold protein binding GO:0097110 9.16 NLGN3 NLGN4X
3 carboxylic ester hydrolase activity GO:0052689 8.96 NLGN3 NLGN4X
4 neurexin family protein binding GO:0042043 8.62 NLGN3 NLGN4X

Sources for Atypical Autism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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