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MCID: ATY001
MIFTS: 40

Atypical Depressive Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Atypical Depressive Disorder

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MalaCards integrated aliases for Atypical Depressive Disorder:

Name: Atypical Depressive Disorder 12 15 74
Atypical Depression 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12294
ICD9CM 36 296.82
ICD10 34 F32.89
UMLS 74 C0154437
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Summaries for Atypical Depressive Disorder

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Disease Ontology : 12 A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (\

MalaCards based summary : Atypical Depressive Disorder, also known as atypical depression, is related to avoidant personality disorder and social phobia. An important gene associated with Atypical Depressive Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Arginine and proline metabolism. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and pituitary.

Wikipedia : 77 Atypical depression as it has been known in the DSM IV, is depression that shares many of the typical... more...

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Related Diseases for Atypical Depressive Disorder

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Diseases related to Atypical Depressive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 avoidant personality disorder 29.6 MAOA SLC6A4
2 social phobia 29.6 MAOA SLC6A4
3 agoraphobia 29.6 MAOA SLC6A4
4 personality disorder 29.4 HTR2A MAOA SLC6A4
5 borderline personality disorder 29.2 HTR2A MAOA SLC6A4
6 bulimia nervosa 29.0 HTR2A SLC6A4
7 anxiety 29.0 CRH HTR2A MAOA SLC6A4
8 fibromyalgia 28.9 CRH HTR2A SLC6A4
9 chronic fatigue syndrome 28.8 CRH HTR2A MAOA SLC6A4
10 depression 28.8 CRH HTR2A MAOA SLC6A4
11 major depressive disorder 28.7 CRH GATA3 HTR2A MAOA SLC6A4
12 disease of mental health 28.6 CRH HTR2A MAOA SLC6A4
13 mental depression 28.5 CRH GATA3 HTR2A MAOA SLC6A4
14 dysthymic disorder 28.5 GATA3 HTR2A MAOA SLC6A4
15 mood disorder 28.2 CRH HTR2A MAOA MAOB SLC6A4
16 exhibitionism 10.2 MAOA MAOB
17 dependent personality disorder 10.2 MAOA MAOB
18 dystonia 1, torsion, autosomal dominant 10.1 MAOA MAOB
19 paraphilia disorder 10.1 MAOA MAOB
20 pure autonomic failure 10.1 MAOA MAOB
21 phobic disorder 10.1 MAOA SLC6A4
22 oppositional defiant disorder 10.1 MAOA SLC6A4
23 hepatic encephalopathy 10.1 MAOA MAOB
24 norrie disease 10.1 MAOA MAOB
25 conduct disorder 10.1 MAOA SLC6A4
26 substance abuse 10.0 MAOA SLC6A4
27 irritable bowel syndrome 10.0 CRH SLC6A4
28 drug dependence 10.0 CRH SLC6A4
29 eating disorder 10.0 CRH SLC6A4
30 postpartum depression 9.9 CRH MAOA SLC6A4
31 brunner syndrome 9.9 MAOA MAOB SLC6A4
32 antisocial personality disorder 9.9 MAOA MAOB SLC6A4
33 psychosexual disorder 9.9 HTR2A SLC6A4
34 kleptomania 9.9 GATA3 MAOA SLC6A4
35 alcoholic psychosis 9.9 HTR2A SLC6A4
36 periodic limb movement disorder 9.9 HTR2A SLC6A4
37 bipolar i disorder 9.8 HTR2A SLC6A4
38 melancholia 9.8
39 substance dependence 9.8 MAOA SLC6A4
40 malaria 9.7
41 bipolar disorder 9.7
42 paranoid schizophrenia 9.7 HTR2A MAOA SLC6A4
43 generalized anxiety disorder 9.7 HTR2A MAOA SLC6A4
44 tobacco addiction 9.7 HTR2A MAOA SLC6A4
45 migraine with or without aura 1 9.7 HTR2A MAOA SLC6A4
46 schizoaffective disorder 9.7 HTR2A SLC6A4
47 sudden infant death syndrome 9.7 HTR2A MAOA SLC6A4
48 anorexia nervosa 9.7 CRH HTR2A SLC6A4
49 psychotic disorder 9.6 HTR2A MAOB SLC6A4
50 central nervous system disease 9.6 HTR2A MAOB SLC6A4

Comorbidity relations with Atypical Depressive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Major Depressive Disorder
Parkinson Disease, Late-Onset Schizophreniform Disorder

Graphical network of the top 20 diseases related to Atypical Depressive Disorder:



Diseases related to Atypical Depressive Disorder
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Symptoms & Phenotypes for Atypical Depressive Disorder

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Drugs & Therapeutics for Atypical Depressive Disorder

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Drugs for Atypical Depressive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Ziprasidone Approved Phase 4 146939-27-7 60854
4
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
5
Polyestradiol phosphate Approved Phase 4 28014-46-2
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Sertraline Approved Phase 4 79617-96-2 68617
8 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
9 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
10 Peripheral Nervous System Agents Phase 4,Phase 3
11 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
12 Duloxetine Hydrochloride Phase 4
13 Analgesics Phase 4
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
15 Antidepressive Agents Phase 4,Phase 3,Not Applicable
16 Dopamine Agents Phase 4
17 Dopamine Antagonists Phase 4
18 Serotonin Antagonists Phase 4
19 Tranquilizing Agents Phase 4,Not Applicable
20 Antipsychotic Agents Phase 4
21 Serotonin Agents Phase 4,Phase 3
22 Central Nervous System Depressants Phase 4,Not Applicable
23 Sodium Channel Blockers Phase 4
24 Anticonvulsants Phase 4
25 Diuretics, Potassium Sparing Phase 4
26 Serotonin Uptake Inhibitors Phase 4,Phase 3
27 Hormones Phase 4
28 Estradiol 3-benzoate Phase 4
29 Hormone Antagonists Phase 4
30 Contraceptive Agents Phase 4
31 Estradiol 17 beta-cypionate Phase 4
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
33 Estrogens Phase 4
34
Serotonin Investigational, Nutraceutical Phase 4,Phase 3 50-67-9 5202
35
Modafinil Approved, Investigational Phase 2, Phase 3 68693-11-8 4236
36
Citalopram Approved Phase 3 59729-33-8 2771
37
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
38 Central Nervous System Stimulants Phase 2, Phase 3
39 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
40 Wakefulness-Promoting Agents Phase 2, Phase 3
41 Parasympatholytics Phase 3
42 Antidepressive Agents, Second-Generation Phase 3
43 Muscarinic Antagonists Phase 3
44 Cholinergic Antagonists Phase 3
45 Antiparkinson Agents Phase 3
46 Cholinergic Agents Phase 3
47 Autonomic Agents Phase 3
48
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
49
Histamine Approved, Investigational Phase 2 51-45-6 774
50
Histamine Phosphate Phase 2 51-74-1 65513

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression Completed NCT00296699 Phase 4 Duloxetine
2 Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder Completed NCT01168674 Phase 4 ziprasidone;Sugar pill
3 Phenytoin as an Augmentation for SSRI Failures Completed NCT00146237 Phase 4 phenytoin
4 Duloxetine for Chronic Depression: a Double-blind Study Completed NCT00360724 Phase 4 Duloxetine (Cymbalta)
5 Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder Completed NCT00502320 Phase 4 Ramelteon;Placebo
6 Postpartum Depression: Transdermal Estradiol Versus Sertraline Terminated NCT00744328 Phase 4 Transdermal Estradiol;Sertraline
7 Modafinil for Atypical Depression Completed NCT00215176 Phase 2, Phase 3 modafinil
8 Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features Completed NCT00610506 Phase 3 Escitalopram
9 St. John's Wort Extract LI 160 for the Treatment of Atypical Depression Completed NCT00861978 Phase 3 St. John's Wort extract;Placebo
10 Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial Completed NCT00852592 Phase 3
11 Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial Completed NCT01894815 Phase 3 Escitalopram oxalate
12 Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features Terminated NCT00585585 Phase 2 betahistine dihydrochloride
13 Effects of Chromium Picolinate on Food Intake Completed NCT00477854 Not Applicable Chromium Picolinate
14 30-Minute Light Exposure for the Treatment of Seasonal Affective Disorder Completed NCT01462305 Not Applicable
15 Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET Completed NCT02582398 Not Applicable
16 Wake Therapy in the Treatment of Depression Recruiting NCT01431573 Not Applicable Lithium
17 Postnatal Depression, Attachment and Self-defining Memories Recruiting NCT03346551 Not Applicable
18 Alternative Treatments for Premenstrual Dysphoric Disorder Recruiting NCT01799733 Not Applicable

Search NIH Clinical Center for Atypical Depressive Disorder

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Genetic Tests for Atypical Depressive Disorder

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Anatomical Context for Atypical Depressive Disorder

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MalaCards organs/tissues related to Atypical Depressive Disorder:

42
Testes, Ovary, Pituitary, Thyroid
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Publications for Atypical Depressive Disorder

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Articles related to Atypical Depressive Disorder:

(show top 50) (show all 181)
# Title Authors Year
1
Characteristics, comorbidities, and correlates of atypical depression: evidence from the UK Biobank Mental Health Survey. ( 31044683 )
2019
2
Prevalence and clinical features of atypical depression among patients with major depressive disorder in China. ( 30594041 )
2019
3
Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts. ( 28867391 )
2018
4
Atypical depression and double depression predict new-onset cardiovascular disease in U.S. adults. ( 28640965 )
2018
5
Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review. ( 29150144 )
2018
6
Short-term and long-term measures of cortisol in saliva and hair in atypical and non-atypical depression. ( 29397570 )
2018
7
The relationship between atypical depression and insülin resistance in patients with polycystic ovary syndrome and major depression. ( 28168992 )
2017
8
Melancholic and atypical depression as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression. ( 27921338 )
2017
9
Neuropsychological changes in melancholic and atypical depression: A systematic review. ( 28027956 )
2017
10
Musculoskeletal Pain in Melancholic and Atypical Depression. ( 28204727 )
2017
11
Is atypical depression simply a typical depression with unusual symptoms? ( 28754056 )
2017
12
Atypical depression: current perspectives. ( 29033570 )
2017
13
Evidence for increased motor cortical facilitation and decreased inhibition in atypical depression. ( 27028276 )
2016
14
Evidence for Broadening Criteria for Atypical Depression Which May Define a Reactive Depressive Disorder. ( 26258131 )
2015
15
Challenging the validity of the association between oversleeping and overeating in atypical depression. ( 25450239 )
2015
16
Relationship between atypical depression and social anxiety disorder. ( 25454116 )
2015
17
Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression. ( 26461262 )
2015
18
Comorbid atypical depression in borderline personality disorder is common and correlated with anxiety-related psychopathology. ( 24457033 )
2014
19
Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression. ( 24673855 )
2014
20
Duloxetine-bupropion combination for treatment-resistant atypical depression: a double-blind, randomized, placebo-controlled trial. ( 24842649 )
2014
21
Clinical implications of loudness dependence of auditory evoked potentials in patients with atypical depression. ( 24865151 )
2014
22
Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. ( 23089630 )
2013
23
Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population. ( 23216242 )
2013
24
Role of cytokines in atypical depression. ( 21936732 )
2012
25
A review of Atypical depression in relation to the course of depression and changes in HPA axis organization. ( 22497986 )
2012
26
Successful treatment of atypical depression with amisulpride: a case report. ( 23174449 )
2012
27
Are atypical depression, borderline personality disorder and bipolar II disorder overlapping manifestations of a common cyclothymic diathesis? ( 21379356 )
2011
28
The DSM IV diagnoses of melancholic and atypical depression in pregnancy. ( 20949294 )
2011
29
Behavioral activation for the treatment of atypical depression: a pilot open trial. ( 21507998 )
2011
30
Atypical depression is more common than melancholic in fibromyalgia: an observational cohort study. ( 20546614 )
2010
31
Treatment of atypical depression: post-hoc analysis of a randomized controlled study testing the efficacy of sertraline and cognitive behavioural therapy in mildly depressed outpatients. ( 20965118 )
2010
32
Atypical depression is associated with suicide attempt in bipolar disorder. ( 19183125 )
2009
33
Association of MAOA gene functional promoter polymorphism with CSF dopamine turnover and atypical depression. ( 19214141 )
2009
34
Clinical correlates of atypical depression and validation of the French version of the Scale for Atypical Symptoms (SAS). ( 19272652 )
2009
35
Atypical depression: retrospective self-reporting of treatment effectiveness. ( 19291077 )
2009
36
Atypical depression: useful concept, but it's time to revise the DSM-IV criteria. ( 19741592 )
2009
37
Atypical depression: a comprehensive review. ( 19958040 )
2009
38
The efficacy of acute electroconvulsive therapy in atypical depression. ( 18278988 )
2008
39
Atypical depression in children and adolescents. ( 18474203 )
2008
40
Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive. ( 18588602 )
2008
41
ECT not proven for atypical depression. ( 19192452 )
2008
42
Atypical depression: current status and relevance to melancholia. ( 17280572 )
2007
43
Melancholia and atypical depression in the Zurich study: epidemiology, clinical characteristics, course, comorbidity and personality. ( 17280573 )
2007
44
Imaging the neurobiological substrate of atypical depression by SPECT. ( 16896666 )
2007
45
Atypical depression, somatic depression and anxious depression in women: are they gender-preferred phenotypes? ( 17092565 )
2007
46
A spectrum model for depressive conditions: extrapolation of the atypical depression prototype. ( 17306888 )
2007
47
A history of the concept of atypical depression. ( 17335311 )
2007
48
Introduction: new directions in the treatment of atypical depression. ( 17348761 )
2007
49
A history of the concept of atypical depression. ( 17348762 )
2007
50
Atypical depression: a valid subtype? ( 17348763 )
2007
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Variations for Atypical Depressive Disorder

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Expression for Atypical Depressive Disorder

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Search GEO for disease gene expression data for Atypical Depressive Disorder.
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Pathways for Atypical Depressive Disorder

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Pathways related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.67 GATA3 HTR2A MAOA SLC6A4
2
Arginine and proline metabolism 38
Show member pathways
 11.25 MAOA MAOB
3
Glycine, serine and threonine metabolism 38
Show member pathways
 11.19 MAOA MAOB
4
Monoamine Transport 1
Show member pathways
 11.09 MAOA SLC6A4
5
Serotonergic synapse 38
10.98 HTR2A MAOA MAOB SLC6A4
6
Histidine metabolism 38
Show member pathways
 10.96 MAOA MAOB
7
Neurotransmitter Clearance In The Synaptic Cleft 67
Show member pathways
 10.84 MAOA SLC6A4
8
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 62
10.58 HTR2A MAOA SLC6A4
9
noradrenaline and adrenaline degradation 1
Show member pathways
 10.51 MAOA MAOB
10
Dopamine metabolism 1
10.47 MAOA MAOB
11
putrescine degradation III 1
Show member pathways
 10.37 MAOA MAOB
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GO Terms for Atypical Depressive Disorder

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Cellular components related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 8.96 HTR2A SLC6A4
2 integral component of postsynaptic membrane GO:0099055 8.62 HTR2A SLC6A4

Biological processes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.61 CRH GATA3 SLC6A4
2 response to toxic substance GO:0009636 9.48 MAOB SLC6A4
3 memory GO:0007613 9.46 HTR2A SLC6A4
4 response to ethanol GO:0045471 9.43 CRH GATA3 MAOB
5 response to estrogen GO:0043627 9.4 CRH GATA3
6 phosphatidylinositol 3-kinase signaling GO:0014065 9.37 GATA3 HTR2A
7 response to corticosterone GO:0051412 9.32 CRH MAOB
8 neurotransmitter catabolic process GO:0042135 9.16 MAOA MAOB
9 response to drug GO:0042493 9.02 CRH GATA3 HTR2A MAOB SLC6A4
10 dopamine catabolic process GO:0042420 8.96 MAOA MAOB

Molecular functions related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.96 HTR2A SLC6A4
2 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB
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Sources for Atypical Depressive Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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