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MCID: ATY001
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Atypical Depressive Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Atypical Depressive Disorder

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MalaCards integrated aliases for Atypical Depressive Disorder:

Name: Atypical Depressive Disorder 12 15 73
Atypical Depression 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12294
ICD10 33 F32.89
ICD9CM 35 296.82
UMLS 73 C0154437
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Summaries for Atypical Depressive Disorder

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Disease Ontology : 12 A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (\

MalaCards based summary : Atypical Depressive Disorder, also known as atypical depression, is related to personality disorder and avoidant personality disorder. An important gene associated with Atypical Depressive Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Circadian rythm related genes and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Atypical depression, or depression with atypical features as it has been known in the DSM IV, is... more...

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Related Diseases for Atypical Depressive Disorder

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Diseases related to Atypical Depressive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 personality disorder 29.6 HTR2A MAOA SLC6A4
2 avoidant personality disorder 29.5 MAOA SLC6A4
3 social phobia 29.4 MAOA SLC6A4
4 agoraphobia 29.4 MAOA SLC6A4
5 borderline personality disorder 29.4 HTR2A MAOA SLC6A4
6 anxiety 29.3 CRH HTR2A MAOA SLC6A4
7 bulimia nervosa 29.2 HTR2A SLC6A4
8 chronic fatigue syndrome 29.2 CRH HTR2A MAOA SLC6A4
9 depression 29.2 CRH HTR2A MAOA SLC6A4
10 major depressive disorder 29.2 CRH HTR2A MAOA SLC6A4
11 fibromyalgia 29.2 CRH HTR2A SLC6A4
12 bipolar disorder 29.2 CRH HTR2A MAOA SLC6A4
13 dysthymic disorder 28.8 HTR2A HTR7 MAOA SLC6A4
14 exhibitionism 10.1 MAOA MAOB
15 dependent personality disorder 10.1 MAOA MAOB
16 dystonia 1, torsion, autosomal dominant 10.1 MAOA MAOB
17 paraphilia disorder 10.1 MAOA MAOB
18 pure autonomic failure 10.1 MAOA MAOB
19 phobic disorder 10.1 MAOA SLC6A4
20 oppositional defiant disorder 10.0 MAOA SLC6A4
21 hepatic encephalopathy 10.0 MAOA MAOB
22 norrie disease 10.0 MAOA MAOB
23 conduct disorder 10.0 MAOA SLC6A4
24 alcoholic psychosis 10.0 HTR2A SLC6A4
25 periodic limb movement disorder 10.0 HTR2A SLC6A4
26 substance abuse 10.0 MAOA SLC6A4
27 drug dependence 10.0 CRH SLC6A4
28 bipolar i disorder 10.0 HTR2A SLC6A4
29 withdrawal disorder 10.0 CRH HTR7
30 eating disorder 9.9 CRH SLC6A4
31 coronary artery vasospasm 9.9 HTR2A HTR7
32 postpartum depression 9.9 CRH MAOA SLC6A4
33 drug-induced mental disorder 9.9 HTR2A HTR7
34 drug psychosis 9.9 HTR2A HTR7
35 amphetamine abuse 9.9 HTR7 MAOB
36 antisocial personality disorder 9.9 MAOA MAOB SLC6A4
37 paranoid schizophrenia 9.9 HTR2A MAOA SLC6A4
38 schizoaffective disorder 9.9 HTR2A SLC6A4
39 generalized anxiety disorder 9.9 HTR2A MAOA SLC6A4
40 tobacco addiction 9.9 HTR2A MAOA SLC6A4
41 intermittent explosive disorder 9.9 HTR7 SLC6A4
42 sudden infant death syndrome 9.9 HTR2A MAOA SLC6A4
43 alcohol abuse 9.9 HTR2A SLC6A4
44 anorexia nervosa 9.9 CRH HTR2A SLC6A4
45 psychotic disorder 9.8 HTR2A MAOB SLC6A4
46 central nervous system disease 9.8 HTR2A MAOB SLC6A4
47 melancholia 9.8
48 substance dependence 9.8 MAOA SLC6A4
49 kleptomania 9.8 HTR7 MAOA SLC6A4
50 irritable bowel syndrome 9.8 CRH HTR7 SLC6A4

Comorbidity relations with Atypical Depressive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Major Depressive Disorder
Parkinson Disease, Late-Onset Schizophreniform Disorder

Graphical network of the top 20 diseases related to Atypical Depressive Disorder:



Diseases related to Atypical Depressive Disorder
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Symptoms & Phenotypes for Atypical Depressive Disorder

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GenomeRNAi Phenotypes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.47 HTR7
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.47 SLC16A8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.47 SLC16A8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.47 SLC6A4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.47 SLC6A4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.47 HTR7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.47 HTR7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.47 SLC6A4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 SLC6A4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.47 HTR7 SLC16A8 SLC6A4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.47 HTR7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.47 SLC6A4

MGI Mouse Phenotypes related to Atypical Depressive Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 CRH HTR2A HTR7 MAOA MAOB SLC6A4
Sources

Drugs & Therapeutics for Atypical Depressive Disorder

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Drugs for Atypical Depressive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Ziprasidone Approved Phase 4 146939-27-7 60854
4
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
5
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
6
Imipramine Approved Phase 4 50-49-7 3696
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
9
Polyestradiol phosphate Approved Phase 4 28014-46-2
10
Sertraline Approved Phase 4 79617-96-2 68617
11 Dopamine Agents Phase 4
12 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
13 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
14 Duloxetine Hydrochloride Phase 4
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
16 Peripheral Nervous System Agents Phase 4,Phase 3
17 Antidepressive Agents Phase 4,Phase 3,Not Applicable
18 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
19 Analgesics Phase 4
20 Antipsychotic Agents Phase 4
21 Dopamine Antagonists Phase 4
22 Serotonin Antagonists Phase 4
23 Central Nervous System Depressants Phase 4,Not Applicable
24 Serotonin Agents Phase 4,Phase 3
25 Tranquilizing Agents Phase 4,Not Applicable
26 Sodium Channel Blockers Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Anticonvulsants Phase 4
29 Cytochrome P-450 Enzyme Inhibitors Phase 4
30 Antidepressive Agents, Second-Generation Phase 4,Phase 3
31 Serotonin Uptake Inhibitors Phase 4,Phase 3
32 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
33 Adrenergic Agents Phase 4
34 Antidepressive Agents, Tricyclic Phase 4
35 Estradiol 17 beta-cypionate Phase 4
36 Estradiol 3-benzoate Phase 4
37 Estrogens Phase 4
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
39 Contraceptive Agents Phase 4
40 Hormone Antagonists Phase 4
41 Hormones Phase 4
42
Serotonin Investigational, Nutraceutical Phase 4,Phase 3 50-67-9 5202
43
Armodafinil Approved, Investigational Phase 2, Phase 3 112111-43-0
44
Modafinil Approved, Investigational Phase 2, Phase 3 68693-11-8 4236
45
Citalopram Approved Phase 3 59729-33-8 2771
46
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
47 Wakefulness-Promoting Agents Phase 2, Phase 3
48 Central Nervous System Stimulants Phase 2, Phase 3
49 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
50 Parasympatholytics Phase 3

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression Completed NCT00296699 Phase 4 Duloxetine
2 Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder Completed NCT01168674 Phase 4 ziprasidone;Sugar pill
3 Phenytoin as an Augmentation for SSRI Failures Completed NCT00146237 Phase 4 phenytoin
4 Dichotic Listening as a Predictor of Medication Response in Depression Completed NCT00296725 Phase 4 Fluoxetine;Imipramine
5 Duloxetine for Chronic Depression: a Double-blind Study Completed NCT00360724 Phase 4 Duloxetine (Cymbalta)
6 Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder Completed NCT00502320 Phase 4 Ramelteon;Placebo
7 Postpartum Depression: Transdermal Estradiol Versus Sertraline Terminated NCT00744328 Phase 4 Transdermal Estradiol;Sertraline
8 Modafinil for Atypical Depression Completed NCT00215176 Phase 2, Phase 3 modafinil
9 Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features Completed NCT00610506 Phase 3 Escitalopram
10 St. John's Wort Extract LI 160 for the Treatment of Atypical Depression Completed NCT00861978 Phase 3 St. John's Wort extract;Placebo
11 Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial Completed NCT00852592 Phase 3
12 Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial Completed NCT01894815 Phase 3 Escitalopram oxalate
13 Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features Terminated NCT00585585 Phase 2 betahistine dihydrochloride
14 Effects of Chromium Picolinate on Food Intake Completed NCT00477854 Not Applicable Chromium Picolinate
15 Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET Completed NCT02582398 Not Applicable
16 Wake Therapy in the Treatment of Depression Recruiting NCT01431573 Not Applicable Lithium
17 Postnatal Depression, Attachment and Self-defining Memories Recruiting NCT03346551 Not Applicable
18 Alternative Treatments for Premenstrual Dysphoric Disorder Recruiting NCT01799733 Not Applicable

Search NIH Clinical Center for Atypical Depressive Disorder

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Genetic Tests for Atypical Depressive Disorder

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Anatomical Context for Atypical Depressive Disorder

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MalaCards organs/tissues related to Atypical Depressive Disorder:

41
Testes, Ovary, Pituitary, Thyroid
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Publications for Atypical Depressive Disorder

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Articles related to Atypical Depressive Disorder:

(show top 50) (show all 167)
# Title Authors Year
1
Atypical depression and double depression predict new-onset cardiovascular disease in U.S. adults. ( 28640965 )
2018
2
Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review. ( 29150144 )
2018
3
Short-term and long-term measures of cortisol in saliva and hair in atypical and non-atypical depression. ( 29397570 )
2018
4
The relationship between atypical depression and insülin resistance in patients with polycystic ovary syndrome and major depression. ( 28168992 )
2017
5
Neuropsychological changes in melancholic and atypical depression: A systematic review. ( 28027956 )
2017
6
Musculoskeletal Pain in Melancholic and Atypical Depression. ( 28204727 )
2017
7
Is atypical depression simply a typical depression with unusual symptoms? ( 28754056 )
2017
8
Atypical depression: current perspectives. ( 29033570 )
2017
9
Melancholic and atypical depression as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression. ( 27921338 )
2017
10
Evidence for increased motor cortical facilitation and decreased inhibition in atypical depression. ( 27028276 )
2016
11
Challenging the validity of the association between oversleeping and overeating in atypical depression. ( 25450239 )
2015
12
Relationship between atypical depression and social anxiety disorder. ( 25454116 )
2015
13
Evidence for Broadening Criteria for Atypical Depression Which May Define a Reactive Depressive Disorder. ( 26258131 )
2015
14
Comorbid atypical depression in borderline personality disorder is common and correlated with anxiety-related psychopathology. ( 24457033 )
2014
15
Duloxetine-bupropion combination for treatment-resistant atypical depression: a double-blind, randomized, placebo-controlled trial. ( 24842649 )
2014
16
Clinical implications of loudness dependence of auditory evoked potentials in patients with atypical depression. ( 24865151 )
2014
17
Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. ( 23089630 )
2013
18
Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population. ( 23216242 )
2013
19
Role of cytokines in atypical depression. ( 21936732 )
2012
20
A review of Atypical depression in relation to the course of depression and changes in HPA axis organization. ( 22497986 )
2012
21
Successful treatment of atypical depression with amisulpride: a case report. ( 23174449 )
2012
22
The DSM IV diagnoses of melancholic and atypical depression in pregnancy. ( 20949294 )
2011
23
Are atypical depression, borderline personality disorder and bipolar II disorder overlapping manifestations of a common cyclothymic diathesis? ( 21379356 )
2011
24
Behavioral activation for the treatment of atypical depression: a pilot open trial. ( 21507998 )
2011
25
Atypical depression is more common than melancholic in fibromyalgia: an observational cohort study. ( 20546614 )
2010
26
Treatment of atypical depression: post-hoc analysis of a randomized controlled study testing the efficacy of sertraline and cognitive behavioural therapy in mildly depressed outpatients. ( 20965118 )
2010
27
Atypical depression is associated with suicide attempt in bipolar disorder. ( 19183125 )
2009
28
Clinical correlates of atypical depression and validation of the French version of the Scale for Atypical Symptoms (SAS). ( 19272652 )
2009
29
Atypical depression: retrospective self-reporting of treatment effectiveness. ( 19291077 )
2009
30
Atypical depression: useful concept, but it's time to revise the DSM-IV criteria. ( 19741592 )
2009
31
Atypical depression: a comprehensive review. ( 19958040 )
2009
32
The efficacy of acute electroconvulsive therapy in atypical depression. ( 18278988 )
2008
33
Atypical depression in children and adolescents. ( 18474203 )
2008
34
Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive. ( 18588602 )
2008
35
ECT not proven for atypical depression. ( 19192452 )
2008
36
Imaging the neurobiological substrate of atypical depression by SPECT. ( 16896666 )
2007
37
Atypical depression, somatic depression and anxious depression in women: are they gender-preferred phenotypes? ( 17092565 )
2007
38
A spectrum model for depressive conditions: extrapolation of the atypical depression prototype. ( 17306888 )
2007
39
A history of the concept of atypical depression. ( 17335311 )
2007
40
Introduction: new directions in the treatment of atypical depression. ( 17348761 )
2007
41
A history of the concept of atypical depression. ( 17348762 )
2007
42
Atypical depression: a valid subtype? ( 17348763 )
2007
43
Translating the evidence on atypical depression into clinical practice. ( 17348765 )
2007
44
Atypical depression: a valid subtype? ( 17388702 )
2007
45
Translating the evidence on atypical depression into clinical practice. ( 17474801 )
2007
46
Recognition and diagnosis of atypical depression. ( 17640153 )
2007
47
Bulimia nervosa in atypical depression: the mediating role of cyclothymic temperament. ( 16436300 )
2006
48
Atypical depression: category or specifier? ( 16848664 )
2006
49
Modafinil for atypical depression: effects of open-label and double-blind discontinuation treatment. ( 16855454 )
2006
50
Should additional symptoms be included in criteria for atypical depression? ( 16890997 )
2006
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Variations for Atypical Depressive Disorder

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Expression for Atypical Depressive Disorder

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Search GEO for disease gene expression data for Atypical Depressive Disorder.
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Pathways for Atypical Depressive Disorder

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Pathways related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.76 HTR2A MAOA SLC6A4
3
Phenylalanine metabolism 37
Show member pathways
 11.41 MAOA MAOB
4
Arginine and proline metabolism 37
Show member pathways
 11.27 MAOA MAOB
5
Glycine, serine and threonine metabolism 37
Show member pathways
 11.21 MAOA MAOB
6
Monoamine Transport 1
Show member pathways
 11.11 MAOA SLC6A4
7
Serotonergic synapse 37
11.08 HTR2A HTR7 MAOA MAOB SLC6A4
8
Histidine metabolism 37
Show member pathways
 10.99 MAOA MAOB
9
Neurotransmitter Clearance In The Synaptic Cleft 66
Show member pathways
 10.85 MAOA SLC6A4
10
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.7 HTR2A HTR7 MAOA SLC6A4
11
noradrenaline and adrenaline degradation 1
Show member pathways
 10.5 MAOA MAOB
12
Dopamine metabolism 1
10.4 MAOA MAOB
13
putrescine degradation III 1
Show member pathways
 10.27 MAOA MAOB
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GO Terms for Atypical Depressive Disorder

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Cellular components related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.46 HTR2A HTR7 SLC16A8 SLC6A4
2 integral component of presynaptic membrane GO:0099056 8.96 HTR2A SLC6A4
3 integral component of postsynaptic membrane GO:0099055 8.62 HTR2A SLC6A4

Biological processes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.54 CRH HTR2A HTR7
2 response to toxic substance GO:0009636 9.49 MAOB SLC6A4
3 circadian rhythm GO:0007623 9.48 HTR7 SLC6A4
4 memory GO:0007613 9.46 HTR2A SLC6A4
5 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.43 HTR2A HTR7
6 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.4 HTR2A HTR7
7 response to corticosterone GO:0051412 9.32 CRH MAOB
8 vasoconstriction GO:0042310 9.26 HTR7 SLC6A4
9 neurotransmitter catabolic process GO:0042135 9.16 MAOA MAOB
10 dopamine catabolic process GO:0042420 8.96 MAOA MAOB
11 response to drug GO:0042493 8.92 CRH HTR2A MAOB SLC6A4

Molecular functions related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.26 HTR2A HTR7
2 G protein-coupled serotonin receptor activity GO:0004993 9.16 HTR2A HTR7
3 serotonin binding GO:0051378 8.96 HTR2A SLC6A4
4 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB
Sources

Sources for Atypical Depressive Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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