MCID: ATY001
MIFTS: 44

Atypical Depressive Disorder

Categories: Mental diseases
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Aliases & Classifications for Atypical Depressive Disorder

MalaCards integrated aliases for Atypical Depressive Disorder:

Name: Atypical Depressive Disorder 11 14 71
Atypical Depression 11 75

Classifications:



External Ids:

Disease Ontology 11 DOID:12294
ICD9CM 34 296.82
SNOMED-CT 68 277538003
UMLS 71 C0154437

Summaries for Atypical Depressive Disorder

Disease Ontology: 11 A mood disorder that is characterized by mood reactivity and positivity, significant weight gain or increased appetite, excessive sleep or somnolence, a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

MalaCards based summary: Atypical Depressive Disorder, also known as atypical depression, is related to pituitary-dependent cushing's disease and avoidant personality disorder. An important gene associated with Atypical Depressive Disorder is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are Signal Transduction and Spinal cord injury. The drugs Duloxetine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, prefrontal cortex and spinal cord, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: 75 Atypical depression is defined in the DSM IV as depression that shares many of the typical symptoms of... more...

Related Diseases for Atypical Depressive Disorder

Diseases related to Atypical Depressive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
# Related Disease Score Top Affiliating Genes
1 pituitary-dependent cushing's disease 30.2 POMC NR3C1 CRH
2 avoidant personality disorder 30.0 SLC6A4 MAOA
3 body dysmorphic disorder 30.0 SLC6A4 MAOA HTR2A
4 cyclothymic disorder 29.8 SLC6A4 HTR2A HTR1A BDNF
5 agoraphobia 29.7 SLC6A4 MAOA HTR2A HTR1A CRH BDNF
6 back pain 29.7 IL6 CRP BDNF
7 drug dependence 29.6 SLC6A4 POMC MAOA CRH BDNF
8 somatization disorder 29.6 SLC6A4 POMC IL6 CRH
9 melancholia 29.6 SLC6A4 POMC MAOA IL6 HTR2A HTR1A
10 bulimia nervosa 29.6 SLC6A4 MAOA LEP HTR2A BDNF
11 hypochondriasis 29.4 SLC6A4 POMC MAOA HTR2A HTR1A BDNF
12 paine syndrome 29.4 SLC6A4 POMC IL6 CRH BDNF
13 panic disorder 29.2 SLC6A4 POMC MAOA IL6 HTR2A HTR1A
14 dysthymic disorder 29.2 SLC6A4 POMC MAOA IL6 HTR2A HTR1A
15 social phobia 29.1 SLC6A4 SERPINA3 POMC MAOA HTR2A HTR1A
16 personality disorder 29.0 SLC6A4 NR3C1 MAOB MAOA HTR2A HTR1A
17 lipid metabolism disorder 28.9 SERPINA3 POMC LEP IL6 CRP
18 narcolepsy 28.9 MAOA LEP IL6 HTR2A BDNF
19 alcohol use disorder 28.9 SLC6A4 SERPINA3 POMC MAOA IL6 CRP
20 leptin deficiency or dysfunction 28.8 POMC LEP IL6 CRP CRH BDNF
21 psychotic disorder 28.8 SLC6A4 SERPINA3 MAOB MAOA IL6 HTR2A
22 chronic fatigue syndrome 28.7 SLC6A4 SERPINA3 POMC NR3C1 MAOA IL6
23 conn's syndrome 28.7 POMC NR3C2 NR3C1 LEP IL6 CRP
24 borderline personality disorder 28.7 SLC6A4 NR3C1 MAOA HTR2A HTR1A FKBP5
25 sleep apnea 28.6 SLC6A4 LEP IL6 HTR2A CRP BDNF
26 somatoform disorder 28.5 SLC6A4 POMC IL6 HTR2A HTR1A CRP
27 cardiovascular system disease 28.3 SERPINA3 NR3C2 LEP IL6 CRP BDNF
28 fibromyalgia 28.3 SLC6A4 POMC MAOA LEP IL6 HTR2A
29 apnea, obstructive sleep 28.2 POMC NR3C2 LEP IL6 HTR2A CRP
30 alcohol dependence 28.1 SLC6A4 SERPINA3 POMC MAOB MAOA LEP
31 endogenous depression 28.1 SLC6A4 POMC NR3C1 MAOA IL6 HTR2A
32 bipolar disorder 28.0 SLC6A4 NR3C1 MAOA LEP IL6 HTR2A
33 sleep disorder 27.8 SLC6A4 POMC MAOB LEP IL6 HTR2A
34 type 2 diabetes mellitus 27.6 SERPINA3 POMC NR3C2 NR3C1 LEP IL6
35 obsessive-compulsive disorder 27.6 SLC6A4 POMC MAOB MAOA LEP IL6
36 major depressive disorder 27.5 SLC6A4 POMC NR3C2 NR3C1 MAOB MAOA
37 anxiety 27.3 SLC6A4 POMC NR3C1 MAOB MAOA LEP
38 disease of mental health 27.1 SLC6A4 SERPINA3 POMC MCHR2-AS1 MAOA LEP
39 migraine with or without aura 1 27.1 SLC6A4 SERPINA3 POMC MAOB MAOA LEP
40 mood disorder 26.9 SLC6A4 SERPINA3 POMC NR3C2 NR3C1 MAOB
41 post-traumatic stress disorder 26.8 SLC6A4 POMC NR3C2 NR3C1 MAOB MAOA
42 idiopathic hypersomnia 10.4
43 hypersomnia 10.4
44 kluver-bucy syndrome 10.3 SLC6A4 CRH
45 pyromania 10.3 SLC6A4 MAOA
46 premature ovarian failure 7 10.3 POMC CRH
47 exhibitionism 10.3 SLC6A4 MAOA
48 pedophilia 10.3 SLC6A4 MAOA
49 pituitary infarct 10.3 POMC CRH
50 cascade stomach 10.3 SLC6A4 HTR1A

Comorbidity relations with Atypical Depressive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Hypertension, Essential Hypothyroidism
Major Depressive Disorder Parkinson Disease, Late-Onset
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Atypical Depressive Disorder:



Diseases related to Atypical Depressive Disorder

Symptoms & Phenotypes for Atypical Depressive Disorder

MGI Mouse Phenotypes related to Atypical Depressive Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.18 BDNF CRH CRHR1 FKBP5 HTR1A IL6
2 homeostasis/metabolism MP:0005376 10.13 BDNF CRH CRHR1 CRP FKBP5 HTR1A
3 renal/urinary system MP:0005367 9.92 CRH FKBP5 IL6 LEP MAOB NR3C1
4 endocrine/exocrine gland MP:0005379 9.81 BDNF CRH CRHR1 HTR2A IL6 LEP
5 cardiovascular system MP:0005385 9.65 CRHR1 CRP HTR1A IL6 LEP MAOA
6 behavior/neurological MP:0005386 9.5 BDNF CRH CRHR1 FKBP5 HTR1A HTR2A

Drugs & Therapeutics for Atypical Depressive Disorder

Drugs for Atypical Depressive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Duloxetine Approved Phase 4 136434-34-9, 116539-59-4 60835
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Norepinephrine Approved Phase 4 51-41-2 439260
4 Dopamine Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Psychotropic Drugs Phase 4
7 Antidepressive Agents Phase 4
8 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
9 Analgesics Phase 4
10
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
11
Modafinil Approved, Investigational Phase 2, Phase 3 68693-11-8 4236
12
Citalopram Approved Phase 3 59729-32-7, 59729-33-8 2771
13
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
14
Dexetimide Withdrawn Phase 3 21888-98-2 30843
15 Central Nervous System Stimulants Phase 2, Phase 3
16 Parasympatholytics Phase 3
17 Antiparkinson Agents Phase 3
18 Serotonin Uptake Inhibitors Phase 3
19 Muscarinic Antagonists Phase 3
20 Cholinergic Antagonists Phase 3
21 Cholinergic Agents Phase 3
22
Iron Approved 7439-89-6 29936
23
Chromium Approved 7440-47-3 27668
24
Picolinic acid Investigational 98-98-6 1018
25 Iron Chelating Agents
26 Trace Elements
27 Micronutrients
28 Chelating Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression Completed NCT00296699 Phase 4 Duloxetine
2 St. John's Wort Extract LI 160 for the Treatment of Atypical Depression Completed NCT00861978 Phase 3 St. John's Wort extract;Placebo
3 A Study of Modafinil for Atypical Depression Completed NCT00215176 Phase 2, Phase 3 modafinil
4 A Pilot Study -- An Open-Label, Rater-blinded, Flexible-dose, 8-week Trial of Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features. Completed NCT00610506 Phase 3 Escitalopram
5 Effects of Chromium Picolinate on Food Intake, Satiety, and Eating Attitudes in Overweight Women With Food Cravings Completed NCT00477854 Chromium Picolinate

Search NIH Clinical Center for Atypical Depressive Disorder

Genetic Tests for Atypical Depressive Disorder

Anatomical Context for Atypical Depressive Disorder

Organs/tissues related to Atypical Depressive Disorder:

MalaCards : Pituitary, Prefrontal Cortex, Spinal Cord, Thyroid, Brain, Ovary, Cortex

Publications for Atypical Depressive Disorder

Articles related to Atypical Depressive Disorder:

(show top 50) (show all 609)
# Title Authors PMID Year
1
Valosin-containing protein Asp395Gly mutation in a patient with frontotemporal dementia: a case report. 62
36329418 2022
2
Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 62
35522196 2022
3
Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma. 62
35807542 2022
4
Associations of major depressive disorder and related clinical characteristics with 25-hydroxyvitamin D levels in middle-aged adults. 62
33295833 2022
5
Melanocortin Signaling Connecting Systemic Metabolism With Mood Disorders. 62
34344535 2022
6
Predictors of suicidal ideation trajectories in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. 62
35085929 2022
7
[Atypical depression as a risk factor for obstructive sleep apnea syndrome in young adults]. 62
34092378 2022
8
Peripheral and central kynurenine pathway abnormalities in major depression. 62
34999196 2022
9
Mood and anxiety profiles differentially associate with physical conditions in US adolescents. 62
34838604 2022
10
A case of Kleine-Levin syndrome successfully treated with Escitalopram. 62
35847426 2022
11
Body mass index and atypical balance as predictors of winter depression remission in cognitive-behavioral therapy and light therapy. 62
34583100 2022
12
TNF-α, IL-6 and hsCRP in patients with melancholic, atypical and anxious depression: an antibody array analysis related to somatic symptoms. 62
36189181 2022
13
Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study. 62
34737282 2021
14
Oral contraceptives, depressive and insomnia symptoms in adult women with and without depression. 62
34425359 2021
15
An electrophysiological model of major depression: Relevance to clinical subtyping and pharmacological management. 62
34153629 2021
16
Heterogeneity in major depression and its melancholic and atypical specifiers: a secondary analysis of STAR*D. 62
34530785 2021
17
Genetic markers for depressive disorders with earlier age at onset. 62
33189858 2021
18
Major depressive disorder subtypes and depression symptoms in multiple sclerosis: What is different compared to the general population? 62
33631437 2021
19
Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions. 62
33359233 2021
20
The effects of KaiXinSan on depression and its association with lipid profiles: A randomized, double-blinded, placebo-controlled trial. 62
33516143 2021
21
Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts. 62
33542229 2021
22
Is there a relation between major depression and hair cortisol? A systematic review and meta-analysis. 62
33310696 2021
23
Dietary Patterns are Differentially Associated with Atypical and Melancholic Subtypes of Depression. 62
33653007 2021
24
Circulating Inflammation Markers Partly Explain the Link Between the Dietary Inflammatory Index and Depressive Symptoms. 62
34611421 2021
25
Does One Treatment Fit All? Effectiveness of a Multicomponent Cognitive Behavioral Therapy Program in Data-Driven Subtypes of Perinatal Depression. 62
34867528 2021
26
The effects of ketamine on typical and atypical depressive symptoms. 62
32677051 2020
27
Associations between systemic inflammation and somatic depressive symptoms: Findings from the Moli-sani study. 62
32627260 2020
28
Efficacy of Buspirone Augmentation of Escitalopram in Patients with Major Depressive Disorder with and without Atypical Features: A Randomized, 8 Week, Multicenter, Open-Label Clinical Trial. 62
32750760 2020
29
Obesity and Depression: Its Prevalence and Influence as a Prognostic Factor: A Systematic Review. 62
32777922 2020
30
Is inflammation-associated depression atypical depression? 62
31926289 2020
31
Mental health professionals view about the impact of male gender for the treatment of men with depression - a qualitative study. 62
32493263 2020
32
Characteristics, comorbidities, and correlates of atypical depression: evidence from the UK Biobank Mental Health Survey. 62
31044683 2020
33
Cortisol levels in chronic fatigue syndrome and atypical depression measured using hair and saliva specimens. 62
32217231 2020
34
Depression subtypes and obesity in adults: A systematic review and meta-analysis. 62
31724325 2020
35
Circulating leptin, cortisol and gender differences associated with anorexia or obesity in depression. 62
31347937 2020
36
The role of eugeroics in the treatment of affective disorders. 62
32447354 2020
37
Prevalence of Comorbid Anxiety Disorders and Their Associated Factors in Patients with Bipolar Disorder or Major Depressive Disorder. 62
32764945 2020
38
Evaluation of Eating Attitudes, Anger and Impulsivity in Atypical and Non-Atypical Depression and Assessment of Comorbidity of Binge Eating. 62
32303040 2020
39
Prevalence of seasonal depression in a prospective cohort study. 62
30022319 2019
40
Genetic variation of the mineralocorticoid receptor gene (MR, NR3C2) is associated with a conceptual endophenotype of "CRF-hypoactivity". 62
30292651 2019
41
Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells. 62
30693539 2019
42
Association between mood disorders and BMI/overweight using a family study approach. 62
30731280 2019
43
Clinical Predictors of Response to Magnetic Seizure Therapy in Depression: A Preliminary Report. 62
29613946 2019
44
Prevalence and clinical features of atypical depression among patients with major depressive disorder in China. 62
30594041 2019
45
Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study. 62
30786180 2019
46
Selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity. 62
30359642 2019
47
The association of serum C-reactive protein with the occurrence and course of postpartum depression. 62
29654412 2019
48
Prevalence and risk factors of excessive daytime sleepiness in major depression: A study with 703 individuals referred for polysomnography. 62
30223136 2019
49
Chronic Atypical Depression as an Early Feature of Pituitary Adenoma: A Case Report and Literature Review. 62
31428501 2019
50
Bipolar features in major depressive disorder: Results from the Iranian mental health survey (IranMHS). 62
30142591 2018

Variations for Atypical Depressive Disorder

Expression for Atypical Depressive Disorder

Search GEO for disease gene expression data for Atypical Depressive Disorder.

Pathways for Atypical Depressive Disorder

GO Terms for Atypical Depressive Disorder

Biological processes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.1 BDNF CRH CRHR1 HTR1A HTR2A IL6
2 acute-phase response GO:0006953 9.85 SERPINA3 IL6 CRP
3 dopamine catabolic process GO:0042420 9.78 MAOB MAOA
4 neurotransmitter catabolic process GO:0042135 9.76 MAOB MAOA
5 serotonin receptor signaling pathway GO:0007210 9.71 HTR2A HTR1A
6 adrenal gland development GO:0030325 9.63 NR3C1 CRHR1 CRH
7 negative regulation of glucagon secretion GO:0070093 9.62 LEP CRH
8 behavior GO:0007610 9.43 HTR2A HTR1A
9 regulation of corticosterone secretion GO:2000852 9.26 POMC CRHR1
10 negative regulation of lipid storage GO:0010888 9.1 LEP IL6 CRP

Molecular functions related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 primary amine oxidase activity GO:0008131 9.62 MAOB MAOA
2 phenethylamine:oxygen oxidoreductase (deaminating) activity GO:0052596 9.56 MAOB MAOA
3 monoamine oxidase activity GO:0097621 9.46 MAOB MAOA
4 aliphatic amine oxidase activity GO:0052595 9.26 MAOB MAOA
5 serotonin binding GO:0051378 9.1 SLC6A4 HTR2A HTR1A

Sources for Atypical Depressive Disorder

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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