MCID: ATY001
MIFTS: 45

Atypical Depressive Disorder

Categories: Mental diseases

Aliases & Classifications for Atypical Depressive Disorder

MalaCards integrated aliases for Atypical Depressive Disorder:

Name: Atypical Depressive Disorder 12 15 71
Atypical Depression 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12294
ICD9CM 34 296.82
ICD10 32 F32.89
UMLS 71 C0154437

Summaries for Atypical Depressive Disorder

Disease Ontology : 12 A mood disorder that is characterized by mood reactivity and positivity, significant weight gain or increased appetite, excessive sleep or somnolence, a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

MalaCards based summary : Atypical Depressive Disorder, also known as atypical depression, is related to avoidant personality disorder and social phobia. An important gene associated with Atypical Depressive Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Peptide ligand-binding receptors and G-Beta Gamma Signaling. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, heart and testes, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : 74 Atypical depression as it has been known in the DSM IV, is depression that shares many of the typical... more...

Related Diseases for Atypical Depressive Disorder

Diseases related to Atypical Depressive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 avoidant personality disorder 30.5 SLC6A4 MAOA
2 social phobia 30.2 SLC6A4 SERPINA3 MAOA HTR1A
3 premenstrual tension 29.9 POMC HTR1A
4 body dysmorphic disorder 29.9 SLC6A4 MAOA HTR2A
5 pure autonomic failure 29.9 MAOB MAOA
6 agoraphobia 29.8 SLC6A4 MAOA HTR2A HTR1A
7 dysthymic disorder 29.4 SLC6A4 MAOA HTR2A HTR1A CRH BDNF
8 somatization disorder 29.3 SLC6A4 HTR2A HTR1A CRH
9 hypochondriasis 29.1 SLC6A4 POMC HTR2A HTR1A BDNF
10 drug dependence 28.9 SLC6A4 POMC CRHR1 CRH BDNF
11 narcolepsy 28.7 SLC6A4 MAOA LEP HTR2A BDNF
12 polycystic ovary syndrome 28.6 POMC LEP CRP
13 melancholia 28.5 SLC6A4 POMC MAOA HTR2A HTR1A CRP
14 sexual disorder 28.3 SLC6A4 POMC HTR2C HTR2A HTR1A
15 alcohol use disorder 28.2 SLC6A4 HTR2C HTR2A HTR1A CRH BDNF
16 chronic fatigue syndrome 28.1 SLC6A4 POMC NR3C1 MAOA HTR2A HTR1A
17 fibromyalgia 28.0 SLC6A4 POMC LEP HTR2A CRP CRH
18 bulimia nervosa 27.6 SLC6A4 POMC MAOA LEP HTR2C HTR2A
19 panic disorder 27.4 SLC6A4 POMC MAOA HTR2C HTR2A HTR1A
20 depression 27.3 SLC6A4 MAOA HTR2C HTR2A HTR1A CRHR1
21 borderline personality disorder 27.1 SLC6A4 NR3C1 MAOA HTR2C HTR2A HTR1A
22 personality disorder 27.1 SLC6A4 NR3C1 MAOB MAOA HTR2C HTR2A
23 sleep disorder 26.6 SLC6A4 POMC LEP HTR2C HTR2A HTR1A
24 mood disorder 26.4 SLC6A4 POMC NR3C1 MAOB MAOA HTR2C
25 obsessive-compulsive disorder 26.4 SLC6A4 POMC MAOB MAOA LEP HTR2C
26 endogenous depression 26.2 SLC6A4 POMC NR3C1 MAOA HTR2C HTR2A
27 alcohol dependence 26.1 SLC6A4 POMC MAOB MAOA LEP HTR2C
28 bipolar disorder 26.1 SLC6A4 NR3C1 MAOA LEP HTR2C HTR2A
29 migraine with or without aura 1 25.9 SLC6A4 POMC MAOB MAOA LEP HTR2C
30 anxiety 25.9 SLC6A4 POMC NR3C1 MAOB MAOA HTR2C
31 major depressive disorder 25.8 SLC6A4 POMC NR3C1 MAOB MAOA LEP
32 mental depression 25.5 SLC6A4 SERPINA3 POMC NR3C1 MAOA HTR2C
33 disease of mental health 24.9 SLC6A4 SERPINA3 POMC MCHR2-AS1 MAOA LEP
34 acth-dependent cushing syndrome 10.5 POMC CRH
35 hypoadrenalism 10.4 POMC CRH
36 pituitary infarct 10.4 POMC CRH
37 fasting hypoglycemia 10.4 POMC CRH
38 ectopic cushing syndrome 10.4 POMC CRH
39 barbiturate abuse 10.4 MAOB MAOA
40 sheehan syndrome 10.4 POMC CRH
41 gangliocytoma 10.4 POMC CRH
42 hypersomnia 10.4
43 ovarian serous adenofibroma 10.3 POMC NR3C1
44 alcoholic psychosis 10.3 SLC6A4 HTR2A
45 acth deficiency, isolated 10.3 POMC CRH
46 corticosteroid-binding globulin deficiency 10.3 POMC NR3C1
47 opiate dependence 10.3 SLC6A4 POMC CRH
48 heroin dependence 10.3 SLC6A4 MAOA BDNF
49 conduct disorder 10.3 SLC6A4 POMC MAOA
50 obsessive-compulsive personality disorder 10.2 SLC6A4 HTR2A

Comorbidity relations with Atypical Depressive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Hypertension, Essential Hypothyroidism
Major Depressive Disorder Parkinson Disease, Late-Onset
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Atypical Depressive Disorder:



Diseases related to Atypical Depressive Disorder

Symptoms & Phenotypes for Atypical Depressive Disorder

GenomeRNAi Phenotypes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 BDNF CRHR1 HTR2C MAOA NR3C1 POMC

MGI Mouse Phenotypes related to Atypical Depressive Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 BDNF CRH CRHR1 HTR1A HTR2A HTR2C
2 homeostasis/metabolism MP:0005376 9.93 BDNF CRH CRHR1 CRP HTR1A HTR2C
3 endocrine/exocrine gland MP:0005379 9.86 BDNF CRH CRHR1 HTR2A LEP NR3C1
4 nervous system MP:0003631 9.7 BDNF CRH CRHR1 HTR1A HTR2C LEP
5 no phenotypic analysis MP:0003012 9.1 BDNF CRH CRHR1 HTR1A NR3C1 POMC

Drugs & Therapeutics for Atypical Depressive Disorder

Drugs for Atypical Depressive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
4
Ziprasidone Approved Phase 4 146939-27-7 60854
5 Analgesics Phase 4
6 Dopamine Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Psychotropic Drugs Phase 4
9 Duloxetine Hydrochloride Phase 4
10 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
11 Antidepressive Agents Phase 4
12 Serotonin Agents Phase 4
13 Dopamine Uptake Inhibitors Phase 4
14 Cytochrome P-450 Enzyme Inhibitors Phase 4
15 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
16 Antipsychotic Agents Phase 4
17 Tranquilizing Agents Phase 4
18 Dopamine Antagonists Phase 4
19 Central Nervous System Depressants Phase 4
20 Serotonin Antagonists Phase 4
21
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
22
Modafinil Approved, Investigational Phase 2, Phase 3 68693-11-8 4236
23
Citalopram Approved Phase 3 59729-33-8 2771
24
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
25 Central Nervous System Stimulants Phase 2, Phase 3
26 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
27 Serotonin Uptake Inhibitors Phase 3
28 Antiparkinson Agents Phase 3
29 Muscarinic Antagonists Phase 3
30 Cholinergic Agents Phase 3
31 Autonomic Agents Phase 3
32 Cholinergic Antagonists Phase 3
33 Parasympatholytics Phase 3
34
Iron Approved, Experimental Phase 1, Phase 2 7439-89-6, 15438-31-0 23925 27284
35
Chromium Approved Phase 1, Phase 2 7440-47-3 27668
36
Histamine Approved, Investigational Phase 2 51-45-6 774
37
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
38 Nutrients Phase 1, Phase 2
39 Chelating Agents Phase 1, Phase 2
40 Iron Chelating Agents Phase 1, Phase 2
41 Trace Elements Phase 1, Phase 2
42 Micronutrients Phase 1, Phase 2
43
Picolinic acid Phase 1, Phase 2 98-98-6 1018
44 Vasodilator Agents Phase 2
45
Histamine Phosphate Phase 2 51-74-1 65513
46
Hydrocortisone acetate Approved, Vet_approved 50-03-3
47
Hydrocortisone Approved, Vet_approved 50-23-7 5754
48 Hydrocortisone hemisuccinate
49 Hydrocortisone 17-butyrate 21-propionate
50 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression Completed NCT00296699 Phase 4 Duloxetine
2 An Open-Label, 8-week Trial of Bupropion Hydrochloride Extended Release (Wellbutrin XL®) In Patients With Major Depressive Disorder (MDD) With Atypical Features. Completed NCT01477931 Phase 4 Bupropion extended release
3 Duloxetine for Chronic Depression: a Double-blind Study Completed NCT00360724 Phase 4 Duloxetine (Cymbalta)
4 Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder : A 13-week, Double-Blind, Placebo-Controlled, Cross-Over Trial Completed NCT01168674 Phase 4 ziprasidone;Sugar pill
5 A Study of Modafinil for Atypical Depression Completed NCT00215176 Phase 2, Phase 3 modafinil
6 St. John's Wort Extract LI 160 for the Treatment of Atypical Depression Completed NCT00861978 Phase 3 St. John's Wort extract;Placebo
7 A Pilot Study -- An Open-Label, Rater-blinded, Flexible-dose, 8-week Trial of Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features. Completed NCT00610506 Phase 3 Escitalopram
8 Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial Completed NCT00852592 Phase 3
9 Chromium Picolinate in Binge Eating Disorder: A Feasibility Study Completed NCT00904306 Phase 1, Phase 2
10 A Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features Terminated NCT00585585 Phase 2 betahistine dihydrochloride
11 Atomoxetine, Diurnal Profiles of Cortisol and α-amylase, Possible Biological Markers of Treatment Success Unknown status NCT03075579 Medication Other
12 The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors Completed NCT01317147
13 A Multicenter, Randomized, Blinded, Controlled, Parallel Group Trial to Demonstrate the Efficacy of rEEG Guided Pharmacotherapy of Subjects With Depression Treatment Failure Completed NCT00437827
14 Postnatal Depression, Attachment and Self-defining Memories Recruiting NCT03346551

Search NIH Clinical Center for Atypical Depressive Disorder

Genetic Tests for Atypical Depressive Disorder

Anatomical Context for Atypical Depressive Disorder

MalaCards organs/tissues related to Atypical Depressive Disorder:

40
Pituitary, Heart, Testes, Brain, Cortex, Thyroid, Spinal Cord

Publications for Atypical Depressive Disorder

Articles related to Atypical Depressive Disorder:

(show top 50) (show all 575)
# Title Authors PMID Year
1
Depression subtypes and obesity in adults: A systematic review and meta-analysis. 61
31724325 2020
2
Is inflammation-associated depression atypical depression? 61
31926289 2020
3
Prevalence of seasonal depression in a prospective cohort study. 61
30022319 2019
4
Circulating leptin, cortisol and gender differences associated with anorexia or obesity in depression. 61
31347937 2019
5
Genetic variation of the mineralocorticoid receptor gene (MR, NR3C2) is associated with a conceptual endophenotype of "CRF-hypoactivity". 61
30292651 2019
6
Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells. 61
30693539 2019
7
Characteristics, comorbidities, and correlates of atypical depression: evidence from the UK Biobank Mental Health Survey. 61
31044683 2019
8
Association between mood disorders and BMI/overweight using a family study approach. 61
30731280 2019
9
Clinical Predictors of Response to Magnetic Seizure Therapy in Depression: A Preliminary Report. 61
29613946 2019
10
Prevalence and clinical features of atypical depression among patients with major depressive disorder in China. 61
30594041 2019
11
Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study. 61
30786180 2019
12
Selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity. 61
30359642 2019
13
The association of serum C-reactive protein with the occurrence and course of postpartum depression. 61
29654412 2019
14
Prevalence and risk factors of excessive daytime sleepiness in major depression: A study with 703 individuals referred for polysomnography. 61
30223136 2019
15
Chronic Atypical Depression as an Early Feature of Pituitary Adenoma: A Case Report and Literature Review. 61
31428501 2019
16
Bipolar features in major depressive disorder: Results from the Iranian mental health survey (IranMHS). 61
30142591 2018
17
Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. 61
29807322 2018
18
Opposite Molecular Signatures of Depression in Men and Women. 61
29548746 2018
19
Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review. 61
29150144 2018
20
Antiepileptic effect of olanzapine in epilepsy patients with atypical depressive comorbidity. 61
29905158 2018
21
Metabolic and inflammatory markers: associations with individual depressive symptoms. 61
28889804 2018
22
Short-term and long-term measures of cortisol in saliva and hair in atypical and non-atypical depression. 61
29397570 2018
23
Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts. 61
28867391 2018
24
Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial. 61
28969438 2018
25
Atypical depression and double depression predict new-onset cardiovascular disease in U.S. adults. 61
28640965 2018
26
[Clinical-psychopathological aspects of therapeutic effects of agomelatine (valdoxan) and its place in perfection of methods of therapy of postschizophrenic depressive disorders]. 61
29652308 2018
27
[The features of psychopharmacotherapy of depressive states with panic attacks]. 61
29863695 2018
28
Big Five personality characteristics are associated with depression subtypes and symptom dimensions of depression in older adults. 61
28092410 2017
29
The relationship between atypical depression and insülin resistance in patients with polycystic ovary syndrome and major depression. 61
28168992 2017
30
Schizophrenia dissection by five anxiety and depressive subtype comorbidities: Clinical implications and evolutionary perspective. 61
28763736 2017
31
Telephone-Based Depression Care Management for Postpartum Women: A Randomized Controlled Trial. 61
28796940 2017
32
Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder. 61
27660275 2017
33
A combined marker of early non-improvement and the occurrence of melancholic features improve the treatment prediction in patients with Major Depressive Disorders. 61
28647668 2017
34
Depression differed by midnight cortisol secretion, alexithymia and anxiety between diabetes types: a cross sectional comparison. 61
28931368 2017
35
Is atypical depression simply a typical depression with unusual symptoms? 61
28754056 2017
36
Tranylcypromine in mind (Part II): Review of clinical pharmacology and meta-analysis of controlled studies in depression. 61
28579071 2017
37
Bipolar At-Risk Criteria: An Examination of Which Clinical Features Have Optimal Utility for Identifying Youth at Risk of Early Transition From Depression to Bipolar Disorders. 61
27872258 2017
38
Mood symptoms in pregnant and postpartum women with bipolar disorder: a naturalistic study. 61
28665044 2017
39
Leptin Dysregulation Is Specifically Associated With Major Depression With Atypical Features: Evidence for a Mechanism Connecting Obesity and Depression. 61
26742925 2017
40
Melancholic and atypical depression as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression. 61
27921338 2017
41
Neuropsychological changes in melancholic and atypical depression: A systematic review. 61
28027956 2017
42
Musculoskeletal Pain in Melancholic and Atypical Depression. 61
28204727 2017
43
[Development of the Interpersonal Sensitivity/Privileged Self Scale: The measurement of a psychological characteristic related to “Modern-type Depression”]. 61
29630299 2017
44
Why do stimulants not work in typical depression? 61
27807011 2017
45
Atypical depression: current perspectives. 61
29033570 2017
46
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. 61
27723543 2017
47
Bipolar disorder and antithyroid antibodies: review and case series. 61
26869176 2016
48
Antidepressant treatment differentially affects the phenotype of high and low stress reactive mice. 61
27395785 2016
49
Familial aggregation and heritability of the melancholic and atypical subtypes of depression. 61
27450632 2016
50
Factors associated with onset timing, symptoms, and severity of depression identified in the postpartum period. 61
27285724 2016

Variations for Atypical Depressive Disorder

Expression for Atypical Depressive Disorder

Search GEO for disease gene expression data for Atypical Depressive Disorder.

Pathways for Atypical Depressive Disorder

Pathways related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 POMC NR3C1 LEP HTR2C HTR2A HTR1A
2
Show member pathways
12.78 POMC HTR2C HTR2A CRHR1 CRH BDNF
3 11.92 POMC CRHR1 CRH
4 11.84 SLC6A4 NR3C1 MAOA HTR2A HTR1A BDNF
5
Show member pathways
11.8 MAOB MAOA BDNF
6
Show member pathways
11.74 HTR2C HTR2A HTR1A
7 11.62 POMC CRHR1 CRH
8 11.49 SLC6A4 MAOB MAOA HTR2C HTR2A HTR1A
9
Show member pathways
11.06 POMC LEP CRP
10
Show member pathways
10.92 SLC6A4 MAOB MAOA HTR1A
11 10.91 NR3C1 LEP
12 10.86 HTR2C HTR2A
13 10.85 POMC LEP HTR2C
14
Show member pathways
10.71 MAOB MAOA
15 10.66 MAOB MAOA
16
Show member pathways
10.61 MAOB MAOA
17 10.47 SLC6A4 MAOA HTR2C HTR2A HTR1A
18 10.34 POMC CRHR1 CRH

GO Terms for Atypical Depressive Disorder

Biological processes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.06 POMC HTR2C HTR2A HTR1A CRHR1 CRH
2 chemical synaptic transmission GO:0007268 9.81 HTR2C HTR2A HTR1A CRH
3 signal transduction GO:0007165 9.81 POMC NR3C1 LEP HTR2C HTR2A HTR1A
4 response to drug GO:0042493 9.8 SLC6A4 MAOB HTR2C HTR2A CRH
5 response to ethanol GO:0045471 9.77 MAOB LEP CRH
6 female pregnancy GO:0007565 9.75 LEP CRHR1 CRH
7 memory GO:0007613 9.74 SLC6A4 HTR2A BDNF
8 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.65 HTR2C HTR2A HTR1A
9 response to corticosterone GO:0051412 9.61 MAOB CRH
10 vasoconstriction GO:0042310 9.6 SLC6A4 HTR1A
11 neurotransmitter catabolic process GO:0042135 9.56 MAOB MAOA
12 parturition GO:0007567 9.55 CRHR1 CRH
13 dopamine catabolic process GO:0042420 9.54 MAOB MAOA
14 negative regulation of lipid storage GO:0010888 9.52 LEP CRP
15 regulation of appetite GO:0032098 9.49 POMC HTR2C
16 negative regulation of glucagon secretion GO:0070093 9.46 LEP CRH
17 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.43 HTR2C HTR2A
18 regulation of corticosterone secretion GO:2000852 9.37 POMC CRHR1
19 regulation of serotonin secretion GO:0014062 9.32 HTR1A CRH
20 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.26 HTR2C HTR2A
21 behavior GO:0007610 9.13 HTR2C HTR2A HTR1A
22 serotonin receptor signaling pathway GO:0007210 8.8 HTR2C HTR2A HTR1A

Molecular functions related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 POMC LEP CRH
2 neurotransmitter receptor activity GO:0030594 9.43 HTR2C HTR2A HTR1A
3 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR2C HTR2A HTR1A
4 primary amine oxidase activity GO:0008131 9.32 MAOB MAOA
5 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2C HTR2A
6 serotonin binding GO:0051378 8.92 SLC6A4 HTR2C HTR2A HTR1A

Sources for Atypical Depressive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
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44 MESH via Orphanet
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48 NCI
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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