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MCID: ATY001
MIFTS: 34

Atypical Depressive Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Atypical Depressive Disorder

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MalaCards integrated aliases for Atypical Depressive Disorder:

Name: Atypical Depressive Disorder 12 15 73
Atypical Depression 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:12294
ICD10 33 F32.8
ICD9CM 35 296.82
UMLS 73 C0154437
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Summaries for Atypical Depressive Disorder

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Disease Ontology : 12 A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (\

MalaCards based summary : Atypical Depressive Disorder, also known as atypical depression, is related to depression and avoidant personality disorder. An important gene associated with Atypical Depressive Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Circadian rythm related genes and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Atypical depression, or depression with atypical features as it has been known in the DSM IV, is... more...

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Related Diseases for Atypical Depressive Disorder

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Diseases related to Atypical Depressive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 depression 29.3 CRH MAOA SLC6A4
2 avoidant personality disorder 10.4 CRH MAOA
3 phobic disorder 10.4 MAOA SLC6A4
4 social phobia 10.3 MAOA SLC6A4
5 oppositional defiant disorder 10.3 MAOA SLC6A4
6 agoraphobia 10.3 MAOA SLC6A4
7 fibromyalgia 10.3 CRH SLC6A4
8 paranoid schizophrenia 10.2 MAOA SLC6A4
9 exhibitionism 10.2 MAOA MAOB
10 early-onset schizophrenia 10.2 MAOA SLC6A4
11 dependent personality disorder 10.2 MAOA MAOB
12 borderline personality disorder 10.2 MAOA SLC6A4
13 generalized anxiety disorder 10.2 MAOA SLC6A4
14 dystonia 1, torsion, autosomal dominant 10.2 MAOA MAOB
15 conduct disorder 10.2 MAOA SLC6A4
16 paraphilia disorder 10.2 MAOA MAOB
17 pure autonomic failure 10.1 MAOA MAOB
18 bulimia nervosa 10.1 MAOA SLC6A4
19 substance abuse 10.1 MAOA SLC6A4
20 norrie disease 10.0 MAOA MAOB
21 eating disorder 10.0 CRH SLC6A4
22 hepatic encephalopathy 10.0 MAOA MAOB
23 withdrawal disorder 9.9 CRH HTR7
24 drug dependence 9.9 CRH SLC6A4
25 postpartum depression 9.9 CRH MAOA SLC6A4
26 chronic fatigue syndrome 9.9 CRH MAOA SLC6A4
27 anxiety 9.9 CRH MAOA SLC6A4
28 panic disorder 9.9 CRH MAOA SLC6A4
29 psychosexual disorder 9.8 HTR7 SLC6A4
30 chronic pulmonary heart disease 9.8 HTR7 SLC6A4
31 intermittent explosive disorder 9.8 HTR7 SLC6A4
32 substance dependence 9.8 MAOA SLC6A4
33 pathological gambling 9.7 MAOA MAOB SLC6A4
34 antisocial personality disorder 9.7 MAOA MAOB SLC6A4
35 serotonin syndrome 9.7 MAOA MAOB SLC6A4
36 bipolar disorder 9.7 CRH MAOA SLC6A4
37 personality disorder 9.6 MAOA MAOB SLC6A4
38 amphetamine abuse 9.6 HTR7 MAOB
39 attention deficit-hyperactivity disorder 9.5 MAOA MAOB SLC6A4
40 parkinson disease, late-onset 9.5 MAOA MAOB SLC6A4
41 irritable bowel syndrome 9.4 CRH HTR7 SLC6A4
42 specific developmental disorder 9.3 HTR7 SLC6A4
43 major depressive disorder 9.3 CRH GATA3 MAOA SLC6A4
44 post-traumatic stress disorder 9.2 CRH MAOA MAOB SLC6A4
45 mood disorder 9.2 CRH MAOA MAOB SLC6A4
46 disease of mental health 9.0 CRH HTR7 MAOA SLC6A4
47 dysthymic disorder 8.8 GATA3 HTR7 MAOA SLC6A4
48 kleptomania 8.8 GATA3 HTR7 MAOA SLC6A4
49 brunner syndrome 8.7 HTR7 MAOA MAOB SLC6A4
50 migraine with or without aura 1 8.7 HTR7 MAOA MAOB SLC6A4

Comorbidity relations with Atypical Depressive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Major Depressive Disorder
Parkinson Disease, Late-Onset Schizophreniform Disorder

Graphical network of the top 20 diseases related to Atypical Depressive Disorder:



Diseases related to Atypical Depressive Disorder
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Symptoms & Phenotypes for Atypical Depressive Disorder

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GenomeRNAi Phenotypes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.47 HTR7
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.47 SLC16A8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.47 SLC16A8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.47 SLC6A4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.47 SLC6A4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.47 HTR7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.47 HTR7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.47 SLC6A4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 SLC6A4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.47 SLC6A4 HTR7 SLC16A8
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.47 HTR7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.47 SLC6A4

MGI Mouse Phenotypes related to Atypical Depressive Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 MAOB SLC6A4 CRH GATA3 HTR7 MAOA
2 nervous system MP:0003631 9.1 MAOB SLC6A4 CRH GATA3 HTR7 MAOA
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Drugs & Therapeutics for Atypical Depressive Disorder

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Drugs for Atypical Depressive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Ziprasidone Approved Phase 4 146939-27-7 60854
4
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
5
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
6
Imipramine Approved Phase 4 50-49-7 3696
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
9
Polyestradiol phosphate Approved Phase 4 28014-46-2
10
Sertraline Approved Phase 4 79617-96-2 68617
11 Analgesics Phase 4
12 Antidepressive Agents Phase 4,Phase 3,Not Applicable
13 Dopamine Agents Phase 4
14 Duloxetine Hydrochloride Phase 4
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
16 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
19 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
20 Antipsychotic Agents Phase 4
21 Central Nervous System Depressants Phase 4,Not Applicable
22 Dopamine Antagonists Phase 4
23 Serotonin Agents Phase 4,Phase 3
24 Serotonin Antagonists Phase 4
25 Tranquilizing Agents Phase 4,Not Applicable
26 Anticonvulsants Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Sodium Channel Blockers Phase 4
29 Adrenergic Agents Phase 4
30 Antidepressive Agents, Second-Generation Phase 4,Phase 3
31 Antidepressive Agents, Tricyclic Phase 4
32 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
33 Cytochrome P-450 Enzyme Inhibitors Phase 4
34 Serotonin Uptake Inhibitors Phase 4,Phase 3
35 Contraceptive Agents Phase 4
36 Estradiol 17 beta-cypionate Phase 4
37 Estradiol 3-benzoate Phase 4
38 Estrogens Phase 4
39 Hormone Antagonists Phase 4
40 Hormones Phase 4
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
42
Serotonin Investigational, Nutraceutical Phase 4,Phase 3 50-67-9 5202
43
Armodafinil Approved, Investigational Phase 2, Phase 3 112111-43-0
44
Modafinil Approved, Investigational Phase 2, Phase 3 68693-11-8 4236
45
Citalopram Approved Phase 3 59729-33-8 2771
46
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
47 Central Nervous System Stimulants Phase 2, Phase 3
48 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
49 Wakefulness-Promoting Agents Phase 2, Phase 3
50 Antiparkinson Agents Phase 3

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression Completed NCT00296699 Phase 4 Duloxetine
2 Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder Completed NCT01168674 Phase 4 ziprasidone;Sugar pill
3 Phenytoin as an Augmentation for SSRI Failures Completed NCT00146237 Phase 4 phenytoin
4 Dichotic Listening as a Predictor of Medication Response in Depression Completed NCT00296725 Phase 4 Fluoxetine;Imipramine
5 Duloxetine for Chronic Depression: a Double-blind Study Completed NCT00360724 Phase 4 Duloxetine (Cymbalta)
6 Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder Completed NCT00502320 Phase 4 Ramelteon;Placebo
7 Postpartum Depression: Transdermal Estradiol Versus Sertraline Terminated NCT00744328 Phase 4 Transdermal Estradiol;Sertraline
8 Modafinil for Atypical Depression Completed NCT00215176 Phase 2, Phase 3 modafinil
9 Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features Completed NCT00610506 Phase 3 Escitalopram
10 St. John's Wort Extract LI 160 for the Treatment of Atypical Depression Completed NCT00861978 Phase 3 St. John's Wort extract;Placebo
11 Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial Completed NCT00852592 Phase 3
12 Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial Completed NCT01894815 Phase 3 Escitalopram oxalate
13 Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features Terminated NCT00585585 Phase 2 betahistine dihydrochloride
14 Effects of Chromium Picolinate on Food Intake Completed NCT00477854 Not Applicable Chromium Picolinate
15 Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET Completed NCT02582398 Not Applicable
16 Wake Therapy in the Treatment of Depression Recruiting NCT01431573 Not Applicable Lithium
17 Postnatal Depression, Attachment and Self-defining Memories Recruiting NCT03346551 Not Applicable
18 Alternative Treatments for Premenstrual Dysphoric Disorder Recruiting NCT01799733 Not Applicable

Search NIH Clinical Center for Atypical Depressive Disorder

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Genetic Tests for Atypical Depressive Disorder

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Anatomical Context for Atypical Depressive Disorder

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MalaCards organs/tissues related to Atypical Depressive Disorder:

41
Testes
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Publications for Atypical Depressive Disorder

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Articles related to Atypical Depressive Disorder:

# Title Authors Year
1
Rolipram versus imipramine in inpatients with major, &amp;quot;minor&amp;quot; or atypical depressive disorder: a double-blind double-dummy study aimed at testing a novel therapeutic approach. ( 3153712 )
1988
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Variations for Atypical Depressive Disorder

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Expression for Atypical Depressive Disorder

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Search GEO for disease gene expression data for Atypical Depressive Disorder.
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Pathways for Atypical Depressive Disorder

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Pathways related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.76 GATA3 MAOA SLC6A4
3
Tyrosine metabolism 37
Show member pathways
 11.4 MAOA MAOB
4
Arginine and proline metabolism 37
Show member pathways
 11.27 MAOA MAOB
5
Glycine, serine and threonine metabolism 37
Show member pathways
 11.21 MAOA MAOB
6
Monoamine Transport 1
Show member pathways
 11.11 MAOA SLC6A4
7
Histidine metabolism 37
Show member pathways
 10.99 MAOA MAOB
8
Serotonergic synapse 37
10.98 HTR7 MAOA MAOB SLC6A4
9
Neurotransmitter Clearance In The Synaptic Cleft 66
Show member pathways
 10.85 MAOA SLC6A4
10
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.58 HTR7 MAOA SLC6A4
11
noradrenaline and adrenaline degradation 1
Show member pathways
 10.5 MAOA MAOB
12
Dopamine metabolism 1
10.4 MAOA MAOB
13
putrescine degradation III 1
Show member pathways
 10.27 MAOA MAOB
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GO Terms for Atypical Depressive Disorder

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Biological processes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.58 CRH GATA3 SLC6A4
2 circadian rhythm GO:0007623 9.46 HTR7 SLC6A4
3 response to estrogen GO:0043627 9.43 CRH GATA3
4 vasoconstriction GO:0042310 9.37 HTR7 SLC6A4
5 response to ethanol GO:0045471 9.33 CRH GATA3 MAOB
6 response to corticosterone GO:0051412 9.32 CRH MAOB
7 neurotransmitter catabolic process GO:0042135 9.26 MAOA MAOB
8 dopamine catabolic process GO:0042420 8.96 MAOA MAOB
9 response to drug GO:0042493 8.92 CRH GATA3 MAOB SLC6A4

Molecular functions related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB
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Sources for Atypical Depressive Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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