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MCID: ATY001
MIFTS: 40

Atypical Depressive Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Atypical Depressive Disorder

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MalaCards integrated aliases for Atypical Depressive Disorder:

Name: Atypical Depressive Disorder 12 15 74
Atypical Depression 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12294
ICD9CM 36 296.82
ICD10 34 F32.89
UMLS 74 C0154437
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Summaries for Atypical Depressive Disorder

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Disease Ontology : 12 A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (\

MalaCards based summary : Atypical Depressive Disorder, also known as atypical depression, is related to avoidant personality disorder and social phobia. An important gene associated with Atypical Depressive Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Tyrosine metabolism. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and pituitary.

Wikipedia : 77 Atypical depression as it has been known in the DSM IV, is depression that shares many of the typical... more...

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Related Diseases for Atypical Depressive Disorder

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Diseases related to Atypical Depressive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 avoidant personality disorder 29.6 MAOA SLC6A4
2 social phobia 29.6 MAOA SLC6A4
3 agoraphobia 29.5 MAOA SLC6A4
4 personality disorder 29.4 HTR2A MAOA SLC6A4
5 borderline personality disorder 29.1 HTR2A MAOA SLC6A4
6 bulimia nervosa 29.0 HTR2A SLC6A4
7 anxiety 28.9 CRH HTR2A MAOA SLC6A4
8 fibromyalgia 28.9 CRH HTR2A SLC6A4
9 depression 28.8 CRH HTR2A MAOA SLC6A4
10 chronic fatigue syndrome 28.8 CRH HTR2A MAOA SLC6A4
11 major depressive disorder 28.6 CRH GATA3 HTR2A MAOA SLC6A4
12 mental depression 28.5 CRH GATA3 HTR2A MAOA SLC6A4
13 dysthymic disorder 28.5 GATA3 HTR2A MAOA SLC6A4
14 mood disorder 28.2 CRH HTR2A MAOA MAOB SLC6A4
15 exhibitionism 10.2 MAOA MAOB
16 dependent personality disorder 10.2 MAOA MAOB
17 dystonia 1, torsion, autosomal dominant 10.1 MAOA MAOB
18 paraphilia disorder 10.1 MAOA MAOB
19 pure autonomic failure 10.1 MAOA MAOB
20 phobic disorder 10.1 MAOA SLC6A4
21 oppositional defiant disorder 10.1 MAOA SLC6A4
22 hepatic encephalopathy 10.1 MAOA MAOB
23 norrie disease 10.1 MAOA MAOB
24 conduct disorder 10.1 MAOA SLC6A4
25 substance abuse 10.0 MAOA SLC6A4
26 irritable bowel syndrome 10.0 CRH SLC6A4
27 drug dependence 10.0 CRH SLC6A4
28 eating disorder 9.9 CRH SLC6A4
29 postpartum depression 9.9 CRH MAOA SLC6A4
30 brunner syndrome 9.9 MAOA MAOB SLC6A4
31 antisocial personality disorder 9.9 MAOA MAOB SLC6A4
32 psychosexual disorder 9.9 HTR2A SLC6A4
33 kleptomania 9.9 GATA3 MAOA SLC6A4
34 alcoholic psychosis 9.9 HTR2A SLC6A4
35 periodic limb movement disorder 9.9 HTR2A SLC6A4
36 bipolar i disorder 9.8 HTR2A SLC6A4
37 melancholia 9.8
38 substance dependence 9.8 MAOA SLC6A4
39 malaria 9.7
40 bipolar disorder 9.7
41 paranoid schizophrenia 9.7 HTR2A MAOA SLC6A4
42 generalized anxiety disorder 9.7 HTR2A MAOA SLC6A4
43 tobacco addiction 9.7 HTR2A MAOA SLC6A4
44 migraine with or without aura 1 9.7 HTR2A MAOA SLC6A4
45 schizoaffective disorder 9.7 HTR2A SLC6A4
46 sudden infant death syndrome 9.7 HTR2A MAOA SLC6A4
47 anorexia nervosa 9.7 CRH HTR2A SLC6A4
48 psychotic disorder 9.6 HTR2A MAOB SLC6A4
49 central nervous system disease 9.6 HTR2A MAOB SLC6A4
50 alcohol abuse 9.6 HTR2A SLC6A4

Comorbidity relations with Atypical Depressive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Major Depressive Disorder
Parkinson Disease, Late-Onset Schizophreniform Disorder

Graphical network of the top 20 diseases related to Atypical Depressive Disorder:



Diseases related to Atypical Depressive Disorder
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Symptoms & Phenotypes for Atypical Depressive Disorder

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Drugs & Therapeutics for Atypical Depressive Disorder

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Drugs for Atypical Depressive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Ziprasidone Approved Phase 4 146939-27-7 60854
4
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
5
Imipramine Approved Phase 4 50-49-7 3696
6
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
7
Sertraline Approved Phase 4 79617-96-2 68617
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
10 Dopamine Agents Phase 4
11 Duloxetine Hydrochloride Phase 4
12 Antidepressive Agents Phase 4,Phase 3,Not Applicable
13 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
14 Peripheral Nervous System Agents Phase 4,Phase 3
15 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
17 Analgesics Phase 4
18 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
19 Dopamine Antagonists Phase 4
20 Tranquilizing Agents Phase 4,Not Applicable
21 Antipsychotic Agents Phase 4
22 Serotonin Agents Phase 4,Phase 3
23 Serotonin Antagonists Phase 4
24 Central Nervous System Depressants Phase 4,Not Applicable
25 Sodium Channel Blockers Phase 4
26 Anticonvulsants Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Antidepressive Agents, Tricyclic Phase 4
29 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
30 Adrenergic Agents Phase 4
31 Antidepressive Agents, Second-Generation Phase 4,Phase 3
32 Serotonin Uptake Inhibitors Phase 4,Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 4
34 Estrogens Phase 4
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
36 Estradiol 3-benzoate Phase 4
37 Estradiol 17 beta-cypionate Phase 4
38 Hormone Antagonists Phase 4
39 Contraceptive Agents Phase 4
40 Hormones Phase 4
41
Serotonin Investigational, Nutraceutical Phase 4,Phase 3 50-67-9 5202
42
Modafinil Approved, Investigational Phase 2, Phase 3 68693-11-8 4236
43
Citalopram Approved Phase 3 59729-33-8 2771
44
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
45 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
46 Wakefulness-Promoting Agents Phase 2, Phase 3
47 Central Nervous System Stimulants Phase 2, Phase 3
48 Muscarinic Antagonists Phase 3
49 Parasympatholytics Phase 3
50 Cholinergic Antagonists Phase 3

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression Completed NCT00296699 Phase 4 Duloxetine
2 Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder Completed NCT01168674 Phase 4 ziprasidone;Sugar pill
3 Phenytoin as an Augmentation for SSRI Failures Completed NCT00146237 Phase 4 phenytoin
4 Dichotic Listening as a Predictor of Medication Response in Depression Completed NCT00296725 Phase 4 Fluoxetine;Imipramine
5 Duloxetine for Chronic Depression: a Double-blind Study Completed NCT00360724 Phase 4 Duloxetine (Cymbalta)
6 Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder Completed NCT00502320 Phase 4 Ramelteon;Placebo
7 Postpartum Depression: Transdermal Estradiol Versus Sertraline Terminated NCT00744328 Phase 4 Transdermal Estradiol;Sertraline
8 Modafinil for Atypical Depression Completed NCT00215176 Phase 2, Phase 3 modafinil
9 Escitalopram (Lexapro®) In Patients With Major Depression With Atypical Features Completed NCT00610506 Phase 3 Escitalopram
10 St. John's Wort Extract LI 160 for the Treatment of Atypical Depression Completed NCT00861978 Phase 3 St. John's Wort extract;Placebo
11 Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial Completed NCT00852592 Phase 3
12 Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial Completed NCT01894815 Phase 3 Escitalopram oxalate
13 Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features Terminated NCT00585585 Phase 2 betahistine dihydrochloride
14 Effects of Chromium Picolinate on Food Intake Completed NCT00477854 Not Applicable Chromium Picolinate
15 30-Minute Light Exposure for the Treatment of Seasonal Affective Disorder Completed NCT01462305 Not Applicable
16 Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET Completed NCT02582398 Not Applicable
17 Wake Therapy in the Treatment of Depression Recruiting NCT01431573 Not Applicable Lithium
18 Postnatal Depression, Attachment and Self-defining Memories Recruiting NCT03346551 Not Applicable
19 Alternative Treatments for Premenstrual Dysphoric Disorder Recruiting NCT01799733 Not Applicable

Search NIH Clinical Center for Atypical Depressive Disorder

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Genetic Tests for Atypical Depressive Disorder

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Anatomical Context for Atypical Depressive Disorder

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MalaCards organs/tissues related to Atypical Depressive Disorder:

42
Testes, Ovary, Pituitary, Thyroid
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Publications for Atypical Depressive Disorder

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Articles related to Atypical Depressive Disorder:

(show top 50) (show all 168)
# Title Authors Year
1
Prevalence and clinical features of atypical depression among patients with major depressive disorder in China. ( 30594041 )
2019
2
Atypical depression and double depression predict new-onset cardiovascular disease in U.S. adults. ( 28640965 )
2018
3
Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review. ( 29150144 )
2018
4
Short-term and long-term measures of cortisol in saliva and hair in atypical and non-atypical depression. ( 29397570 )
2018
5
The relationship between atypical depression and insülin resistance in patients with polycystic ovary syndrome and major depression. ( 28168992 )
2017
6
Neuropsychological changes in melancholic and atypical depression: A systematic review. ( 28027956 )
2017
7
Musculoskeletal Pain in Melancholic and Atypical Depression. ( 28204727 )
2017
8
Is atypical depression simply a typical depression with unusual symptoms? ( 28754056 )
2017
9
Atypical depression: current perspectives. ( 29033570 )
2017
10
Melancholic and atypical depression as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression. ( 27921338 )
2017
11
Evidence for increased motor cortical facilitation and decreased inhibition in atypical depression. ( 27028276 )
2016
12
Evidence for Broadening Criteria for Atypical Depression Which May Define a Reactive Depressive Disorder. ( 26258131 )
2015
13
Challenging the validity of the association between oversleeping and overeating in atypical depression. ( 25450239 )
2015
14
Relationship between atypical depression and social anxiety disorder. ( 25454116 )
2015
15
Comorbid atypical depression in borderline personality disorder is common and correlated with anxiety-related psychopathology. ( 24457033 )
2014
16
Duloxetine-bupropion combination for treatment-resistant atypical depression: a double-blind, randomized, placebo-controlled trial. ( 24842649 )
2014
17
Clinical implications of loudness dependence of auditory evoked potentials in patients with atypical depression. ( 24865151 )
2014
18
Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. ( 23089630 )
2013
19
Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population. ( 23216242 )
2013
20
Role of cytokines in atypical depression. ( 21936732 )
2012
21
A review of Atypical depression in relation to the course of depression and changes in HPA axis organization. ( 22497986 )
2012
22
Successful treatment of atypical depression with amisulpride: a case report. ( 23174449 )
2012
23
Are atypical depression, borderline personality disorder and bipolar II disorder overlapping manifestations of a common cyclothymic diathesis? ( 21379356 )
2011
24
The DSM IV diagnoses of melancholic and atypical depression in pregnancy. ( 20949294 )
2011
25
Behavioral activation for the treatment of atypical depression: a pilot open trial. ( 21507998 )
2011
26
Atypical depression is more common than melancholic in fibromyalgia: an observational cohort study. ( 20546614 )
2010
27
Treatment of atypical depression: post-hoc analysis of a randomized controlled study testing the efficacy of sertraline and cognitive behavioural therapy in mildly depressed outpatients. ( 20965118 )
2010
28
Atypical depression is associated with suicide attempt in bipolar disorder. ( 19183125 )
2009
29
Clinical correlates of atypical depression and validation of the French version of the Scale for Atypical Symptoms (SAS). ( 19272652 )
2009
30
Atypical depression: retrospective self-reporting of treatment effectiveness. ( 19291077 )
2009
31
Atypical depression: useful concept, but it's time to revise the DSM-IV criteria. ( 19741592 )
2009
32
Atypical depression: a comprehensive review. ( 19958040 )
2009
33
The efficacy of acute electroconvulsive therapy in atypical depression. ( 18278988 )
2008
34
Atypical depression in children and adolescents. ( 18474203 )
2008
35
Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive. ( 18588602 )
2008
36
ECT not proven for atypical depression. ( 19192452 )
2008
37
Imaging the neurobiological substrate of atypical depression by SPECT. ( 16896666 )
2007
38
Atypical depression, somatic depression and anxious depression in women: are they gender-preferred phenotypes? ( 17092565 )
2007
39
A spectrum model for depressive conditions: extrapolation of the atypical depression prototype. ( 17306888 )
2007
40
A history of the concept of atypical depression. ( 17335311 )
2007
41
Introduction: new directions in the treatment of atypical depression. ( 17348761 )
2007
42
A history of the concept of atypical depression. ( 17348762 )
2007
43
Atypical depression: a valid subtype? ( 17348763 )
2007
44
Translating the evidence on atypical depression into clinical practice. ( 17348765 )
2007
45
Atypical depression: a valid subtype? ( 17388702 )
2007
46
Translating the evidence on atypical depression into clinical practice. ( 17474801 )
2007
47
Recognition and diagnosis of atypical depression. ( 17640153 )
2007
48
Bulimia nervosa in atypical depression: the mediating role of cyclothymic temperament. ( 16436300 )
2006
49
Atypical depression: category or specifier? ( 16848664 )
2006
50
Modafinil for atypical depression: effects of open-label and double-blind discontinuation treatment. ( 16855454 )
2006
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Variations for Atypical Depressive Disorder

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Expression for Atypical Depressive Disorder

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Search GEO for disease gene expression data for Atypical Depressive Disorder.
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Pathways for Atypical Depressive Disorder

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Pathways related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.67 GATA3 HTR2A MAOA SLC6A4
2
Tyrosine metabolism 38
Show member pathways
 11.39 MAOA MAOB
3
Arginine and proline metabolism 38
Show member pathways
 11.25 MAOA MAOB
4
Glycine, serine and threonine metabolism 38
Show member pathways
 11.19 MAOA MAOB
5
Monoamine Transport 1
Show member pathways
 11.09 MAOA SLC6A4
6
Serotonergic synapse 38
10.98 HTR2A MAOA MAOB SLC6A4
7
Histidine metabolism 38
Show member pathways
 10.96 MAOA MAOB
8
Neurotransmitter Clearance In The Synaptic Cleft 67
Show member pathways
 10.82 MAOA SLC6A4
9
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 62
10.58 HTR2A MAOA SLC6A4
10
noradrenaline and adrenaline degradation 1
Show member pathways
 10.54 MAOA MAOB
11
Dopamine metabolism 1
10.47 MAOA MAOB
12
putrescine degradation III 1
Show member pathways
 10.37 MAOA MAOB
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GO Terms for Atypical Depressive Disorder

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Cellular components related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 8.96 HTR2A SLC6A4
2 integral component of postsynaptic membrane GO:0099055 8.62 HTR2A SLC6A4

Biological processes related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.61 CRH GATA3 SLC6A4
2 response to toxic substance GO:0009636 9.48 MAOB SLC6A4
3 memory GO:0007613 9.46 HTR2A SLC6A4
4 response to ethanol GO:0045471 9.43 CRH GATA3 MAOB
5 response to estrogen GO:0043627 9.4 CRH GATA3
6 phosphatidylinositol 3-kinase signaling GO:0014065 9.37 GATA3 HTR2A
7 response to corticosterone GO:0051412 9.32 CRH MAOB
8 neurotransmitter catabolic process GO:0042135 9.16 MAOA MAOB
9 response to drug GO:0042493 9.02 CRH GATA3 HTR2A MAOB SLC6A4
10 dopamine catabolic process GO:0042420 8.96 MAOA MAOB

Molecular functions related to Atypical Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.96 HTR2A SLC6A4
2 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB
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Sources for Atypical Depressive Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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