MCID: ADG002
MIFTS: 25

Audiogenic Seizures

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Audiogenic Seizures

MalaCards integrated aliases for Audiogenic Seizures:

Name: Audiogenic Seizures 58
Audiogenic Seizure 54 70

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G40.5
UMLS via Orphanet 71 C0751791
Orphanet 58 ORPHA166415
UMLS 70 C0596131

Summaries for Audiogenic Seizures

MalaCards based summary : Audiogenic Seizures, also known as audiogenic seizure, is related to seizure disorder and ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. An important gene associated with Audiogenic Seizures is GIPC3 (GIPC PDZ Domain Containing Family Member 3). Affiliated tissues include amygdala, cortex and cerebellum, and related phenotypes are reproductive system and vision/eye

Related Diseases for Audiogenic Seizures

Diseases related to Audiogenic Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 seizure disorder 11.3
2 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
3 fragile x syndrome 10.3
4 branchiootic syndrome 1 10.3
5 epilepsy 10.3
6 hearing loss, noise-induced 10.2
7 tremor 10.2
8 ataxia and polyneuropathy, adult-onset 10.1
9 alacrima, achalasia, and mental retardation syndrome 10.1
10 west syndrome 10.1
11 pain agnosia 10.1
12 cardiac arrest 10.1
13 status epilepticus 10.1
14 focal epilepsy 10.1
15 reflex epilepsy 10.1
16 epilepsy with generalized tonic-clonic seizures 10.1
17 pyridoxine deficiency 10.1
18 age-related hearing loss 10.1
19 febrile seizures 10.1
20 cleft palate, isolated 10.0
21 anxiety 10.0
22 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 10.0
23 autosomal recessive disease 10.0
24 microphthalmia 10.0
25 movement disease 10.0
26 middle ear disease 10.0
27 dystonia 10.0
28 herpes simplex 10.0
29 genetic reflex epilepsy 10.0
30 hyperacusis 10.0
31 scn8a encephalopathy 10.0
32 depression 10.0
33 encephalopathy 10.0
34 myoclonus 10.0
35 paroxysmal dystonia 10.0
36 deafness, unilateral 10.0
37 hypercholesterolemia, familial, 1 10.0
38 otitis media 10.0
39 parkinson disease, late-onset 10.0
40 down syndrome 10.0
41 hypogonadism, male 10.0
42 sudden infant death syndrome 10.0
43 aicardi syndrome 10.0
44 corpus callosum, partial agenesis of, x-linked 10.0
45 deafness, autosomal recessive 15 10.0
46 developmental and epileptic encephalopathy 28 10.0
47 cleft palate, psychomotor retardation, and distinctive facial features 10.0
48 congenital hypothyroidism 10.0
49 withdrawal disorder 10.0
50 ptosis 10.0

Graphical network of the top 20 diseases related to Audiogenic Seizures:



Diseases related to Audiogenic Seizures

Symptoms & Phenotypes for Audiogenic Seizures

MGI Mouse Phenotypes related to Audiogenic Seizures:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 FMR1 FOS GIPC3
2 vision/eye MP:0005391 8.8 FMR1 FOS GIPC3

Drugs & Therapeutics for Audiogenic Seizures

Search Clinical Trials , NIH Clinical Center for Audiogenic Seizures

Genetic Tests for Audiogenic Seizures

Anatomical Context for Audiogenic Seizures

MalaCards organs/tissues related to Audiogenic Seizures:

40
Amygdala, Cortex, Cerebellum, Caudate Nucleus, Adrenal Cortex, Pituitary, Brain

Publications for Audiogenic Seizures

Articles related to Audiogenic Seizures:

(show top 50) (show all 1330)
# Title Authors PMID Year
1
Distinct Fos expression in the brain following freezing behavior elicited by stimulation with NMDA of the ventral or dorsal inferior colliculus. 54 61
17289027 2007
2
Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes. 61 54
17007840 2007
3
Audiogenic seizure induces c-fos mRNA expression in the inferior colliculus and not in the hippocampus. 54 61
8612175 1995
4
Author Correction: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. 61
33564096 2021
5
Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures. 61
33387800 2021
6
Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. 61
33420383 2021
7
Cannabinoids in Audiogenic Seizures: From Neuronal Networks to Future Perspectives for Epilepsy Treatment. 61
33643007 2021
8
Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat. 61
33232300 2021
9
Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of SCN8A Encephalopathy. 61
33762902 2021
10
Impaired postnatal development of the hippocampus of Krushinsky-Molodkina rats genetically prone to audiogenic seizures. 61
33161330 2020
11
Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy. 61
33208550 2020
12
Intraperitoneal injection of lipopolysaccharide prevents seizure-induced respiratory arrest in a DBA/1 mouse model of SUDEP. 61
32913947 2020
13
Morphological and molecular correlates of altered hearing sensitivity in the genetically audiogenic seizure-prone hamster GASH/Sal. 61
32402894 2020
14
S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy. 61
32575479 2020
15
(S)-5-(2'-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder. 61
32566916 2020
16
Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome. 61
32319849 2020
17
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. 61
32434848 2020
18
Are Predator Smell (TMT)-Induced Behavioral Alterations in Rats Able to Inhibit Seizures? 61
32246139 2020
19
Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. 61
32109856 2020
20
Audiogenic kindling activates expression of vasopressin in the hypothalamus of Krushinsky-Molodkina rats genetically prone to reflex epilepsy. 61
32301211 2020
21
Inflammatory markers in the hippocampus after audiogenic kindling. 61
32044393 2020
22
Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood. 61
31981213 2020
23
An oxygen-rich atmosphere or systemic fluoxetine extend the time to respiratory arrest in a rat model of obstructive apnea. 61
31759134 2020
24
Seizures induce obstructive apnea in DBA/2J audiogenic seizure-prone mice: Lifesaving impact of tracheal implants. 61
31944280 2020
25
Divergent Effects of Systemic and Intracollicular CB Receptor Activation Against Forebrain and Hindbrain-Evoked Seizures in Rats. 61
33328922 2020
26
Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal. 61
32117006 2020
27
Behavioral and Molecular Effects Induced by Cannabidiol and Valproate Administration in the GASH/Sal Model of Acute Audiogenic Seizures. 61
33551767 2020
28
Cannabinoid Receptor Type 1 (CB1R) Expression in Limbic Brain Structures After Acute and Chronic Seizures in a Genetic Model of Epilepsy. 61
33408620 2020
29
Inferior Colliculus Transcriptome After Status Epilepticus in the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. 61
32528245 2020
30
Analysis of gene variants in the GASH/Sal model of epilepsy. 61
32168507 2020
31
Alterations in brainstem auditory processing, the acoustic startle response and sensorimotor gating of startle in Wistar audiogenic rats (WAR), an animal model of reflex epilepsies. 61
31811837 2020
32
Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats. 61
32455164 2020
33
Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus. 61
31666356 2019
34
Descending projections from the substantia nigra pars reticulata differentially control seizures. 61
31843937 2019
35
Delayed audiogenic seizure development in a genetic rat model is associated with overactivation of ERK1/2 and disturbances in glutamatergic signaling. 61
31493733 2019
36
Amygdala lesions reduce seizure-induced respiratory arrest in DBA/1 mice. 61
31399338 2019
37
Time course of transient expression of pre-α-pro-GDNF and pre-β-pro-GDNF transcripts, and mGDNF mRNA region in Krushinsky-Molodkina rat brain after audiogenic seizures. 61
31112899 2019
38
Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice. 61
31063933 2019
39
Neural activity in the periaqueductal gray and other specific subcortical structures is enhanced when a selective serotonin reuptake inhibitor selectively prevents seizure-induced sudden death in the DBA/1 mouse model of sudden unexpected death in epilepsy. 61
31056750 2019
40
TSP1 and TSP2 Have Unique and Overlapping Roles in Protecting against Noise-Induced Auditory Synaptopathy. 61
30928339 2019
41
Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model. 61
31147392 2019
42
Disruption of Selenium Handling During Puberty Causes Sex-Specific Neurological Impairments in Mice. 61
31022880 2019
43
Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP. 61
30719703 2019
44
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. 61
30813600 2019
45
Maternal reproductive performance and fetal development of the Wistar Audiogenic Rat (WAR) strain. 61
29927665 2019
46
Simultaneous cardiac and respiratory inhibition during seizure precedes death in the DBA/1 audiogenic mouse model of SUDEP. 61
31634345 2019
47
Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy. 61
31632331 2019
48
Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice. 61
31632233 2019
49
Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures. 61
30193173 2018
50
Apoptosis and proliferation in the inferior colliculus during postnatal development and epileptogenesis in audiogenic Krushinsky-Molodkina rats. 61
30316149 2018

Variations for Audiogenic Seizures

Expression for Audiogenic Seizures

Search GEO for disease gene expression data for Audiogenic Seizures.

Pathways for Audiogenic Seizures

GO Terms for Audiogenic Seizures

Cellular components related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.62 FOS FMR1

Biological processes related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 8.62 FOS FMR1

Molecular functions related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.62 FOS FMR1

Sources for Audiogenic Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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