MCID: ADG002
MIFTS: 26

Audiogenic Seizures

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Audiogenic Seizures

MalaCards integrated aliases for Audiogenic Seizures:

Name: Audiogenic Seizures 59
Audiogenic Seizure 55 73

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA166415
UMLS via Orphanet 74 C0751791
UMLS 73 C0596131

Summaries for Audiogenic Seizures

MalaCards based summary : Audiogenic Seizures, also known as audiogenic seizure, is related to epilepsy and ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. An important gene associated with Audiogenic Seizures is GIPC3 (GIPC PDZ Domain Containing Family Member 3). Affiliated tissues include brain, cortex and testes.

Related Diseases for Audiogenic Seizures

Diseases related to Audiogenic Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 epilepsy 10.8
2 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
3 depression 10.4
4 ischemia 10.2
5 hearing loss, noise-induced 10.1
6 cardiac arrest 10.1
7 hypothyroidism 10.1
8 neonatal hypothyroidism 10.1
9 pyridoxine deficiency 10.1
10 seizure disorder 10.1
11 alzheimer disease 10.0
12 otitis media 10.0
13 down syndrome 10.0
14 sudden infant death syndrome 10.0
15 fragile x syndrome 10.0
16 aicardi syndrome 10.0
17 anxiety 10.0
18 sensorineural hearing loss 10.0
19 status epilepticus 10.0
20 focal epilepsy 10.0
21 middle ear disease 10.0
22 albinism 10.0
23 dwarfism 10.0
24 hyperacusis 10.0
25 hypoxia 10.0
26 disease of mental health 9.8 FMR1 FOS
27 attention deficit-hyperactivity disorder 9.7 FMR1 FOS

Graphical network of the top 20 diseases related to Audiogenic Seizures:



Diseases related to Audiogenic Seizures

Symptoms & Phenotypes for Audiogenic Seizures

Drugs & Therapeutics for Audiogenic Seizures

Search Clinical Trials , NIH Clinical Center for Audiogenic Seizures

Genetic Tests for Audiogenic Seizures

Anatomical Context for Audiogenic Seizures

MalaCards organs/tissues related to Audiogenic Seizures:

41
Brain, Cortex, Testes, Amygdala, Thyroid, Adrenal Cortex, Cerebellum

Publications for Audiogenic Seizures

Articles related to Audiogenic Seizures:

(show top 50) (show all 592)
# Title Authors Year
1
Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures. ( 30193173 )
2018
2
Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice. ( 30333725 )
2018
3
Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures. ( 28738742 )
2017
4
Changes in the content of fatty acids in CA1 and CA3 areas of the hippocampus of Krushinsky-Molodkina rats after single and fivefold audiogenic seizures. ( 28692872 )
2017
5
Analysis of ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development. ( 29101749 )
2017
6
Remote effects of short-term neonatal hyperthermia in Krushinsky-Molodkina rats prone to audiogenic seizures strain. ( 28429263 )
2017
7
Molecular and neurochemical substrates of the audiogenic seizure strains: The GASH:Sal model. ( 26071997 )
2017
8
Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal). ( 26876275 )
2017
9
The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal. ( 27072920 )
2017
10
Morphofunctional alterations in the olivocochlear efferent system of the genetic audiogenic seizure-prone hamster GASH:Sal. ( 27492627 )
2017
11
Audiogenic seizure activity following HSV-1 GAD65 sense or antisense injection into inferior colliculus of Long-Evans rat. ( 27993512 )
2017
12
Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treatment. ( 28135595 )
2017
13
Going to WAR: using a rat model of audiogenic seizure to uncover potential links to ventilatory dysfunction in epilepsy. ( 28145010 )
2017
14
Effect of Audiogenic Seizures on the Dynamics of Fatty Acid Composition of Hippocampal Dental Gyrus in Krushinsky-Molodkina Rats. ( 27383177 )
2016
15
Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2'-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. ( 27663280 )
2016
16
Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures. ( 26775236 )
2016
17
A genetic context for the study of audiogenic seizures. ( 26907925 )
2016
18
Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model. ( 26471422 )
2016
19
Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. ( 27663742 )
2016
20
Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures. ( 26033576 )
2015
21
Developmental PCB exposure increases audiogenic seizures and decreases glutamic acid decarboxylase in the inferior colliculus. ( 26543103 )
2015
22
Occurrence of spontaneous and audiogenic seizures following global brain ischaemia due to cardiac arrest. ( 26443315 )
2015
23
The expression and distribution of seizure-related and synaptic proteins in the insular cortex of rats genetically prone to audiogenic seizures. ( 26923581 )
2015
24
An abnormal GABAergic system in the inferior colliculus provides a basis for audiogenic seizures in genetically epilepsy-prone rats. ( 25812940 )
2015
25
Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood. ( 25543072 )
2015
26
Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures. ( 25936592 )
2015
27
Maternal methyl-enriched diet in rat reduced the audiogenic seizure proneness in progeny. ( 25285618 )
2014
28
Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures. ( 24519931 )
2014
29
Inhibition of ERK1/2 signaling prevents epileptiform behavior in rats prone to audiogenic seizures. ( 25351927 )
2014
30
Audiogenic seizure proneness after methyl-enriched diet in ontogeny. ( 24659292 )
2014
31
Amiloride and SN-6 suppress audiogenic seizure susceptibility in genetically epilepsy-prone rats. ( 24948133 )
2014
32
Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout mice. ( 23630463 )
2013
33
EEG characterization of audiogenic seizures in the hamster strain GASH:Sal. ( 23916142 )
2013
34
Pharmacodynamic potentiation of antiepileptic drugs' effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 mice. ( 23253428 )
2013
35
Improved technique for induction and monitoring of audiogenic seizure in deer mice. ( 23604158 )
2013
36
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal). ( 23872084 )
2013
37
Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures. ( 22801414 )
2012
38
Binding of specific ligand by D2- and NMDA-receptors of striatum cells in two rat strains predisposed and resistant to audiogenic seizures. ( 23330123 )
2012
39
Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. ( 22107891 )
2012
40
Audiogenic seizure proneness requires the contribution of two susceptibility loci in mice. ( 21681693 )
2011
41
Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. ( 21326233 )
2011
42
Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior. ( 21872651 )
2011
43
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray. ( 21439272 )
2011
44
Elevated sulfatide levels in neurons cause lethal audiogenic seizures in mice. ( 19860853 )
2010
45
DBA/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest. ( 20335075 )
2010
46
Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures. ( 20413855 )
2010
47
Non-convulsive status epilepticus and audiogenic seizures complicating a patient with asymmetrical epileptic spasms. ( 19735986 )
2010
48
Inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats. ( 20417219 )
2010
49
Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures. ( 19351745 )
2009
50
A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy. ( 19500159 )
2009

Variations for Audiogenic Seizures

Expression for Audiogenic Seizures

Search GEO for disease gene expression data for Audiogenic Seizures.

Pathways for Audiogenic Seizures

GO Terms for Audiogenic Seizures

Cellular components related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.62 FMR1 FOS

Biological processes related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 8.62 FMR1 FOS

Molecular functions related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.96 FMR1 FOS
2 chromatin binding GO:0003682 8.62 FMR1 FOS

Sources for Audiogenic Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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