MCID: ADG002
MIFTS: 26

Audiogenic Seizures

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Audiogenic Seizures

MalaCards integrated aliases for Audiogenic Seizures:

Name: Audiogenic Seizures 58
Audiogenic Seizure 54 71

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

UMLS via Orphanet 72 C0751791
Orphanet 58 ORPHA166415
UMLS 71 C0596131

Summaries for Audiogenic Seizures

MalaCards based summary : Audiogenic Seizures, also known as audiogenic seizure, is related to visual epilepsy and seizure disorder. An important gene associated with Audiogenic Seizures is GIPC3 (GIPC PDZ Domain Containing Family Member 3). Affiliated tissues include brain, amygdala and testes, and related phenotypes are reproductive system and vision/eye

Related Diseases for Audiogenic Seizures

Diseases related to Audiogenic Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 visual epilepsy 11.4
2 seizure disorder 11.4
3 reflex epilepsy 10.6
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
5 fragile x syndrome 10.4
6 branchiootic syndrome 1 10.4
7 status epilepticus 10.3
8 otitis media 10.3
9 hearing loss, noise-induced 10.3
10 cardiac arrest 10.3
11 hypothyroidism 10.3
12 pyridoxine deficiency 10.3
13 autism 10.2
14 alacrima, achalasia, and mental retardation syndrome 10.2
15 west syndrome 10.2
16 congenital hypothyroidism 10.2
17 pain agnosia 10.2
18 sensorineural hearing loss 10.2
19 epilepsy 10.2
20 epilepsy with generalized tonic-clonic seizures 10.2
21 age-related hearing loss 10.2
22 anoxia 10.2
23 febrile seizures 10.2
24 tremor 10.2
25 alzheimer disease 10.0
26 cleft palate, isolated 10.0
27 deafness, unilateral 10.0
28 hypercholesterolemia, familial, 1 10.0
29 parkinson disease, late-onset 10.0
30 down syndrome 10.0
31 hypogonadism, male 10.0
32 sudden infant death syndrome 10.0
33 aicardi syndrome 10.0
34 corpus callosum, partial agenesis of, x-linked 10.0
35 ataxia and polyneuropathy, adult-onset 10.0
36 deafness, autosomal recessive 15 10.0
37 epileptic encephalopathy, early infantile, 28 10.0
38 cleft palate, psychomotor retardation, and distinctive facial features 10.0
39 autosomal recessive disease 10.0
40 withdrawal disorder 10.0
41 ptosis 10.0
42 microphthalmia 10.0
43 allergic hypersensitivity disease 10.0
44 hypogonadism 10.0
45 focal epilepsy 10.0
46 ischemia 10.0
47 movement disease 10.0
48 middle ear disease 10.0
49 sleep disorder 10.0
50 dystonia 10.0

Graphical network of the top 20 diseases related to Audiogenic Seizures:



Diseases related to Audiogenic Seizures

Symptoms & Phenotypes for Audiogenic Seizures

MGI Mouse Phenotypes related to Audiogenic Seizures:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 FMR1 FOS GIPC3
2 vision/eye MP:0005391 8.8 FMR1 FOS GIPC3

Drugs & Therapeutics for Audiogenic Seizures

Search Clinical Trials , NIH Clinical Center for Audiogenic Seizures

Genetic Tests for Audiogenic Seizures

Anatomical Context for Audiogenic Seizures

MalaCards organs/tissues related to Audiogenic Seizures:

40
Brain, Amygdala, Testes, Cortex, Thyroid, Cerebellum, Liver

Publications for Audiogenic Seizures

Articles related to Audiogenic Seizures:

(show top 50) (show all 1305)
# Title Authors PMID Year
1
Distinct Fos expression in the brain following freezing behavior elicited by stimulation with NMDA of the ventral or dorsal inferior colliculus. 54 61
17289027 2007
2
Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes. 54 61
17007840 2007
3
Audiogenic seizure induces c-fos mRNA expression in the inferior colliculus and not in the hippocampus. 54 61
8612175 1995
4
An oxygen-rich atmosphere or systemic fluoxetine extend the time to respiratory arrest in a rat model of obstructive apnea. 61
31759134 2020
5
Alterations in brainstem auditory processing, the acoustic startle response and sensorimotor gating of startle in Wistar audiogenic rats (WAR), an animal model of reflex epilepsies. 61
31811837 2020
6
Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood. 61
31981213 2020
7
Seizures induce obstructive apnea in DBA/2J audiogenic seizure-prone mice: Lifesaving impact of tracheal implants. 61
31944280 2020
8
Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus. 61
31666356 2019
9
Descending projections from the substantia nigra pars reticulata differentially control seizures. 61
31843937 2019
10
Delayed audiogenic seizure development in a genetic rat model is associated with overactivation of ERK1/2 and disturbances in glutamatergic signaling. 61
31493733 2019
11
Amygdala lesions reduce seizure-induced respiratory arrest in DBA/1 mice. 61
31399338 2019
12
Time course of transient expression of pre-α-pro-GDNF and pre-β-pro-GDNF transcripts, and mGDNF mRNA region in Krushinsky-Molodkina rat brain after audiogenic seizures. 61
31112899 2019
13
Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice. 61
31063933 2019
14
Neural activity in the periaqueductal gray and other specific subcortical structures is enhanced when a selective serotonin reuptake inhibitor selectively prevents seizure-induced sudden death in the DBA/1 mouse model of sudden unexpected death in epilepsy. 61
31056750 2019
15
TSP1 and TSP2 Have Unique and Overlapping Roles in Protecting against Noise-Induced Auditory Synaptopathy. 61
30928339 2019
16
Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model. 61
31147392 2019
17
Disruption of Selenium Handling During Puberty Causes Sex-Specific Neurological Impairments in Mice. 61
31022880 2019
18
Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP. 61
30719703 2019
19
Maternal reproductive performance and fetal development of the Wistar Audiogenic Rat (WAR) strain. 61
29927665 2019
20
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. 61
30813600 2019
21
Simultaneous cardiac and respiratory inhibition during seizure precedes death in the DBA/1 audiogenic mouse model of SUDEP. 61
31634345 2019
22
Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy. 61
31632331 2019
23
Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice. 61
31632233 2019
24
Apoptosis and proliferation in the inferior colliculus during postnatal development and epileptogenesis in audiogenic Krushinsky-Molodkina rats. 61
30316149 2018
25
Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures. 61
30193173 2018
26
NEOCORTICAL IMPACT ON THE AUDIOGENIC SEIZURE ACTIVITY DEVELOPMENT. 61
30618407 2018
27
Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats. 61
30092489 2018
28
Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR). 61
29274430 2018
29
ADGRV1 is implicated in myoclonic epilepsy. 61
29266188 2018
30
Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. 61
29097328 2018
31
Intense olfactory stimulation blocks seizures in an experimental model of epilepsy. 61
29346088 2018
32
A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants. 61
30220990 2018
33
STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice. 61
28943283 2018
34
Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy-prone rat. 61
29105300 2018
35
Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice. 61
30333725 2018
36
Autonomous and non-autonomous roles for ephrin-B in interneuron migration. 61
28947178 2017
37
Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice. 61
28973305 2017
38
Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures. 61
28738742 2017
39
Analysis of ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development. 61
29101749 2017
40
Changes in the content of fatty acids in CA1 and CA3 areas of the hippocampus of Krushinsky-Molodkina rats after single and fivefold audiogenic seizures. 61
28692872 2017
41
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. 61
28772121 2017
42
Regulatory BC1 RNA in cognitive control. 61
28620074 2017
43
A genetic context for the study of audiogenic seizures. 61
26907925 2017
44
Reflex epileptic mechanisms in humans: Lessons about natural ictogenesis. 61
25958226 2017
45
The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal. 61
27072920 2017
46
Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures. 61
26775236 2017
47
An abnormal GABAergic system in the inferior colliculus provides a basis for audiogenic seizures in genetically epilepsy-prone rats. 61
25812940 2017
48
Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features. 61
26148984 2017
49
Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility. 61
26440280 2017
50
Audiogenic seizure activity following HSV-1 GAD65 sense or antisense injection into inferior colliculus of Long-Evans rat. 61
27993512 2017

Variations for Audiogenic Seizures

Expression for Audiogenic Seizures

Search GEO for disease gene expression data for Audiogenic Seizures.

Pathways for Audiogenic Seizures

GO Terms for Audiogenic Seizures

Cellular components related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.62 FOS FMR1

Biological processes related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 8.62 FOS FMR1

Molecular functions related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.96 FOS FMR1
2 chromatin binding GO:0003682 8.62 FOS FMR1

Sources for Audiogenic Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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