MCID: ADG002
MIFTS: 25

Audiogenic Seizures

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Audiogenic Seizures

MalaCards integrated aliases for Audiogenic Seizures:

Name: Audiogenic Seizures 58
Audiogenic Seizure 54 71

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G40.5
UMLS via Orphanet 72 C0751791
Orphanet 58 ORPHA166415
UMLS 71 C0596131

Summaries for Audiogenic Seizures

MalaCards based summary : Audiogenic Seizures, also known as audiogenic seizure, is related to visual epilepsy and seizure disorder. An important gene associated with Audiogenic Seizures is GIPC3 (GIPC PDZ Domain Containing Family Member 3). Affiliated tissues include brain, amygdala and testes, and related phenotypes are reproductive system and vision/eye

Related Diseases for Audiogenic Seizures

Diseases related to Audiogenic Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 visual epilepsy 11.4
2 seizure disorder 11.4
3 reflex epilepsy 10.6
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
5 fragile x syndrome 10.4
6 branchiootic syndrome 1 10.4
7 status epilepticus 10.4
8 otitis media 10.3
9 hearing loss, noise-induced 10.3
10 cardiac arrest 10.3
11 hypothyroidism 10.3
12 pyridoxine deficiency 10.3
13 tremor 10.3
14 alacrima, achalasia, and mental retardation syndrome 10.2
15 west syndrome 10.2
16 congenital hypothyroidism 10.2
17 pain agnosia 10.2
18 sensorineural hearing loss 10.2
19 epilepsy 10.2
20 epilepsy with generalized tonic-clonic seizures 10.2
21 age-related hearing loss 10.2
22 anoxia 10.2
23 febrile seizures 10.2
24 alzheimer disease 10.0
25 cleft palate, isolated 10.0
26 deafness, unilateral 10.0
27 hypercholesterolemia, familial, 1 10.0
28 parkinson disease, late-onset 10.0
29 down syndrome 10.0
30 autism 10.0
31 hypogonadism, male 10.0
32 sudden infant death syndrome 10.0
33 aicardi syndrome 10.0
34 corpus callosum, partial agenesis of, x-linked 10.0
35 ataxia and polyneuropathy, adult-onset 10.0
36 deafness, autosomal recessive 15 10.0
37 epileptic encephalopathy, early infantile, 28 10.0
38 cleft palate, psychomotor retardation, and distinctive facial features 10.0
39 autosomal recessive disease 10.0
40 withdrawal disorder 10.0
41 ptosis 10.0
42 microphthalmia 10.0
43 allergic hypersensitivity disease 10.0
44 hypogonadism 10.0
45 focal epilepsy 10.0
46 movement disease 10.0
47 middle ear disease 10.0
48 sleep disorder 10.0
49 dystonia 10.0
50 inherited metabolic disorder 10.0

Graphical network of the top 20 diseases related to Audiogenic Seizures:



Diseases related to Audiogenic Seizures

Symptoms & Phenotypes for Audiogenic Seizures

MGI Mouse Phenotypes related to Audiogenic Seizures:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 FMR1 FOS GIPC3
2 vision/eye MP:0005391 8.8 FMR1 FOS GIPC3

Drugs & Therapeutics for Audiogenic Seizures

Search Clinical Trials , NIH Clinical Center for Audiogenic Seizures

Genetic Tests for Audiogenic Seizures

Anatomical Context for Audiogenic Seizures

MalaCards organs/tissues related to Audiogenic Seizures:

40
Brain, Amygdala, Testes, Cortex, Thyroid, Cerebellum, Liver

Publications for Audiogenic Seizures

Articles related to Audiogenic Seizures:

(show top 50) (show all 1318)
# Title Authors PMID Year
1
Distinct Fos expression in the brain following freezing behavior elicited by stimulation with NMDA of the ventral or dorsal inferior colliculus. 61 54
17289027 2007
2
Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes. 54 61
17007840 2007
3
Audiogenic seizure induces c-fos mRNA expression in the inferior colliculus and not in the hippocampus. 61 54
8612175 1995
4
Morphological and molecular correlates of altered hearing sensitivity in the genetically audiogenic seizure-prone hamster GASH/Sal. 61
32402894 2020
5
S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy. 61
32575479 2020
6
(S)-5-(2'-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder. 61
32566916 2020
7
Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome. 61
32319849 2020
8
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. 61
32434848 2020
9
Are Predator Smell (TMT)-Induced Behavioral Alterations in Rats Able to Inhibit Seizures? 61
32246139 2020
10
Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. 61
32109856 2020
11
Audiogenic kindling activates expression of vasopressin in the hypothalamus of Krushinsky-Molodkina rats genetically prone to reflex epilepsy. 61
32301211 2020
12
Inflammatory markers in the hippocampus after audiogenic kindling. 61
32044393 2020
13
Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood. 61
31981213 2020
14
An oxygen-rich atmosphere or systemic fluoxetine extend the time to respiratory arrest in a rat model of obstructive apnea. 61
31759134 2020
15
Seizures induce obstructive apnea in DBA/2J audiogenic seizure-prone mice: Lifesaving impact of tracheal implants. 61
31944280 2020
16
Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats. 61
32455164 2020
17
Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal. 61
32117006 2020
18
Inferior Colliculus Transcriptome After Status Epilepticus in the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. 61
32528245 2020
19
Analysis of gene variants in the GASH/Sal model of epilepsy. 61
32168507 2020
20
Alterations in brainstem auditory processing, the acoustic startle response and sensorimotor gating of startle in Wistar audiogenic rats (WAR), an animal model of reflex epilepsies. 61
31811837 2020
21
Descending projections from the substantia nigra pars reticulata differentially control seizures. 61
31843937 2019
22
Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus. 61
31666356 2019
23
Delayed audiogenic seizure development in a genetic rat model is associated with overactivation of ERK1/2 and disturbances in glutamatergic signaling. 61
31493733 2019
24
Amygdala lesions reduce seizure-induced respiratory arrest in DBA/1 mice. 61
31399338 2019
25
Time course of transient expression of pre-α-pro-GDNF and pre-β-pro-GDNF transcripts, and mGDNF mRNA region in Krushinsky-Molodkina rat brain after audiogenic seizures. 61
31112899 2019
26
Neural activity in the periaqueductal gray and other specific subcortical structures is enhanced when a selective serotonin reuptake inhibitor selectively prevents seizure-induced sudden death in the DBA/1 mouse model of sudden unexpected death in epilepsy. 61
31056750 2019
27
TSP1 and TSP2 Have Unique and Overlapping Roles in Protecting against Noise-Induced Auditory Synaptopathy. 61
30928339 2019
28
Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice. 61
31063933 2019
29
Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model. 61
31147392 2019
30
Disruption of Selenium Handling During Puberty Causes Sex-Specific Neurological Impairments in Mice. 61
31022880 2019
31
Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP. 61
30719703 2019
32
Maternal reproductive performance and fetal development of the Wistar Audiogenic Rat (WAR) strain. 61
29927665 2019
33
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. 61
30813600 2019
34
Simultaneous cardiac and respiratory inhibition during seizure precedes death in the DBA/1 audiogenic mouse model of SUDEP. 61
31634345 2019
35
Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy. 61
31632331 2019
36
Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice. 61
31632233 2019
37
Apoptosis and proliferation in the inferior colliculus during postnatal development and epileptogenesis in audiogenic Krushinsky-Molodkina rats. 61
30316149 2018
38
Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures. 61
30193173 2018
39
NEOCORTICAL IMPACT ON THE AUDIOGENIC SEIZURE ACTIVITY DEVELOPMENT. 61
30618407 2018
40
Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats. 61
30092489 2018
41
Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR). 61
29274430 2018
42
Intense olfactory stimulation blocks seizures in an experimental model of epilepsy. 61
29346088 2018
43
ADGRV1 is implicated in myoclonic epilepsy. 61
29266188 2018
44
Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. 61
29097328 2018
45
A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants. 61
30220990 2018
46
STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice. 61
28943283 2018
47
Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice. 61
30333725 2018
48
Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy-prone rat. 61
29105300 2018
49
Autonomous and non-autonomous roles for ephrin-B in interneuron migration. 61
28947178 2017
50
Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice. 61
28973305 2017

Variations for Audiogenic Seizures

Expression for Audiogenic Seizures

Search GEO for disease gene expression data for Audiogenic Seizures.

Pathways for Audiogenic Seizures

GO Terms for Audiogenic Seizures

Cellular components related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.62 FOS FMR1

Biological processes related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 8.62 FOS FMR1

Molecular functions related to Audiogenic Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.62 FOS FMR1

Sources for Audiogenic Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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