MCID: ADT002
MIFTS: 27

Auditory System Cancer

Categories: Cancer diseases, Ear diseases, Neuronal diseases

Aliases & Classifications for Auditory System Cancer

MalaCards integrated aliases for Auditory System Cancer:

Name: Auditory System Cancer 12 15
Ear Neoplasms 44

Classifications:



External Ids:

Disease Ontology 12 DOID:833
MeSH 44 D004428
NCIt 50 C3000
SNOMED-CT 67 363228008
UMLS 70 C0013449

Summaries for Auditory System Cancer

Disease Ontology : 12 An organ system cancer located in the ear and characterized by uncontrolled cellular proliferation of the auditory organs.

MalaCards based summary : Auditory System Cancer, also known as ear neoplasms, is related to malignant melanocytic neoplasm of the peripheral nerve sheath and anal neuroendocrine tumor. An important gene associated with Auditory System Cancer is PPY (Pancreatic Polypeptide). The drugs Remifentanil and Propofol have been mentioned in the context of this disorder. Affiliated tissues include ear, lung and pineal.

Related Diseases for Auditory System Cancer

Diseases related to Auditory System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
2 anal neuroendocrine tumor 10.2 SYP ENO2
3 optic nerve astrocytoma 10.2 SYP ENO2
4 cerebral neuroblastoma 10.2 SYP ENO2
5 neuronal intestinal dysplasia, type b 10.2 SYP ENO2
6 lung meningioma 10.2 SYP ENO2
7 sinonasal undifferentiated carcinoma 10.2 SYP ENO2
8 papillary tumor of the pineal region 10.2 SYP ENO2
9 cloacogenic carcinoma 10.2 SYP ENO2
10 pineal region teratoma 10.2 SYP ENO2
11 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.2 SYP ENO2
12 intracranial primitive neuroectodermal tumor 10.2 SYP ENO2
13 bile duct mucinous adenocarcinoma 10.2 SYP ENO2
14 nodular prostate 10.2 SYP ENO2
15 cerebellar liponeurocytoma 10.2 SYP ENO2
16 ganglioneuroblastoma 10.2 SYP ENO2
17 cerebellopontine angle primitive neuroectodermal tumor 10.2 SYP ENO2
18 jejunal neoplasm 10.2 SYP ENO2
19 frontal lobe neoplasm 10.2 SYP ENO2
20 myoblastoma 10.2 SYP ENO2
21 pineal parenchymal tumor of intermediate differentiation 10.2 SYP ENO2
22 kidney rhabdoid cancer 10.2 SYP ENO2
23 spinal cord oligodendroglioma 10.2 SYP ENO2
24 endobronchial leiomyoma 10.2 SYP ENO2
25 orbital cancer 10.2 SYP ENO2
26 non-functioning pancreatic endocrine tumor 10.2 PPY CHGA
27 extraosseous ewing sarcoma 10.2 SYP ENO2
28 small cell osteogenic sarcoma 10.2 SYP ENO2
29 endobronchial lipoma 10.2 SYP ENO2
30 rhabdoid meningioma 10.2 SYP ENO2
31 vaginal glandular tumor 10.2 ENO2 CHGA
32 bladder lateral wall cancer 10.2 SYP ENO2
33 ureter transitional cell carcinoma 10.2 ENO2 CHGA
34 nasal cavity olfactory neuroblastoma 10.2 SYP ENO2
35 cerebrovascular benign neoplasm 10.2 SYP ENO2
36 cerebellum cancer 10.2 SYP ENO2
37 cerebellar medulloblastoma 10.2 SYP ENO2
38 askin's tumor 10.2 SYP ENO2
39 cystadenoma 10.2 SYP CHGA
40 clear cell ependymoma 10.1 SYP ENO2
41 gastric gastrinoma 10.1 ENO2 CHGA
42 pineal gland cancer 10.1 SYP ENO2
43 diamond-blackfan anemia 5 10.1 SYP PPY
44 cystic basal cell carcinoma 10.1 SYP ENO2
45 gangliocytoma 10.1 SYP ENO2
46 central nervous system primitive neuroectodermal neoplasm 10.1 SYP ENO2
47 ependymoblastoma 10.1 SYP ENO2
48 extraosseous chondrosarcoma 10.1 SYP ENO2
49 nodular ganglioneuroblastoma 10.1 ENO2 CHGA
50 subleukemic leukemia 10.1 SYP ENO2

Graphical network of the top 20 diseases related to Auditory System Cancer:



Diseases related to Auditory System Cancer

Symptoms & Phenotypes for Auditory System Cancer

Drugs & Therapeutics for Auditory System Cancer

Drugs for Auditory System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 3 132875-61-7 60815
2
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
3 Anesthetics Phase 3
4 Narcotics Phase 3
5 Pharmaceutical Solutions Phase 3
6 Analgesics, Opioid Phase 3
7 Analgesics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Impact of Adding Remifentanil to Propofol on the Conditions of the Diagnostic Panendoscopy of the Upper Airway Under General Anesthesia With Tubeless Spontaneous Ventilation. Completed NCT02093143 Phase 3 Remifentanil

Search NIH Clinical Center for Auditory System Cancer

Cochrane evidence based reviews: ear neoplasms

Genetic Tests for Auditory System Cancer

Anatomical Context for Auditory System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Auditory System Cancer:

19
Ear

MalaCards organs/tissues related to Auditory System Cancer:

40
Lung, Pineal, Bone, Breast, Appendix, Kidney, Thyroid

Publications for Auditory System Cancer

Articles related to Auditory System Cancer:

(show all 20)
# Title Authors PMID Year
1
Endoscopic excision of a tympanic paraganglioma: Training the next generation of ear surgeons. 61
29516061 2017
2
[The use of the Surgitron radiowave scalpel for the surgical treatment of external ear neoplasms]. 61
27367341 2016
3
A case of sensorineural hearing loss involving a fibroepithelial polyp of the middle ear. 61
25701460 2015
4
Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone. 61
26027747 2015
5
Transcanal endoscopic treatment of benign middle ear neoplasms. 61
23377229 2013
6
[Middle ear adenoma]. 61
20436986 2009
7
[Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms]. 61
17668798 2007
8
[Malignant neoplasms of external and middle ear]. 61
16095097 2005
9
[Middle ear carcinoma]. 61
9644865 1998
10
[Computer tomography in the diagnosis of ear neoplasms]. 61
9334016 1997
11
Tumors of the external ear. 61
7642978 1995
12
[Glandular ear neoplasms]. 61
7644206 1995
13
[Basal cell and basosquamous carcinomas of the external ear. Immunohistochemical study]. 61
7817742 1994
14
[Topographic and anatomic markers of the temporal pyramidal bone and their role in the surgical treatment of ear neoplasms]. 61
8036751 1993
15
[Methodological aspects of radiotherapy in the treatment of ear neoplasms]. 61
2048244 1991
16
Carcinoid tumour of the middle ear. A morphological and immunohistochemical study with comments on histogenesis and differential diagnosis. 61
2481299 1989
17
Middle ear neoplasms showing adenomatous and neuroendocrine components. 61
2715695 1989
18
Carcinoid tumour of the middle ear associated with systemic symptoms. 61
3585164 1987
19
Rhabdomyosarcoma of the middle ear: a wolf in sheep's clothing. 61
7375237 1980
20
[On the angiographic determination of ear neoplasms]. 61
5697315 1968

Variations for Auditory System Cancer

Expression for Auditory System Cancer

Search GEO for disease gene expression data for Auditory System Cancer.

Pathways for Auditory System Cancer

GO Terms for Auditory System Cancer

Cellular components related to Auditory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 RLN2 RECK PPY GCG CHGA

Biological processes related to Auditory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 feeding behavior GO:0007631 8.62 PPY GCG

Molecular functions related to Auditory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 RLN2 PPY GCG

Sources for Auditory System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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