Aliases & Classifications for Auditory System Disease

Summaries for Auditory System Disease

MalaCards based summary : Auditory System Disease, also known as ear diseases, is related to inner ear disease and superior semicircular canal dehiscence, and has symptoms including hyperacusis, tinnitus and snoring. An important gene associated with Auditory System Disease is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways is Gap junction trafficking. The drugs Clavulanate and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related phenotypes are behavior/neurological and hearing/vestibular/ear

Wikipedia : 77 The auditory system is the sensory system for the sense of hearing. It includes both the sensory organs... more...

Related Diseases for Auditory System Disease

Diseases related to Auditory System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 inner ear disease 33.0 CDH23 COCH GJB2 GJB3 GJB6 KCNQ4
2 superior semicircular canal dehiscence 32.0 COCH RTEL1
3 nonsyndromic deafness 29.9 CDH23 COCH GJB2 GJB3 GJB6 KCNQ4
4 sensorineural hearing loss 28.8 CDH23 COCH GJB2 GJB3 GJB6 KCNQ4
5 autoimmune inner ear disease 12.3
6 middle ear disease 12.2
7 external ear disease 12.2
8 mastoiditis 11.0
9 otitis externa 11.0
10 adhesive otitis media 11.0
11 deafness, autosomal dominant 24 10.5 GJB2 GJB6
12 hypotrichosis-deafness syndrome 10.5 GJB2 GJB3
13 deafness, autosomal recessive 9 10.5 GJB2 OTOF
14 deafness, autosomal recessive 93 10.5 GJB2 GJB3
15 knuckle pads, leukonychia, and sensorineural deafness 10.4 GJB2 GJB6
16 kid syndrome 10.4 GJB2 GJB3 GJB6
17 pseudoainhum 10.4 GJB2 GJB3 GJB6
18 deafness, autosomal recessive 3 10.4 GJB2 MYO15A MYO7A
19 deafness, autosomal recessive 8 10.4 STRC TMPRSS3
20 deafness, autosomal recessive 28 10.4 GJB2 GJB3
21 knuckle pads 10.4 GJB2 GJB3 GJB6
22 deafness, autosomal recessive 59 10.4 GJB2 OTOF
23 retinitis pigmentosa-deafness syndrome 10.4 CDH23 MYO7A
24 erythrokeratodermia variabilis et progressiva 1 10.4 GJB2 GJB3 GJB6
25 drug-induced hearing loss 10.4 GJB2 GJB3 SLC26A4
26 deafness, x-linked 2 10.4 GJB2 GJB6 POU3F4
27 congenital cytomegalovirus 10.4 GJB2 GJB6 MT-RNR1
28 clouston syndrome 10.4 GJB2 GJB3 GJB6
29 usher syndrome, type ig 10.4 CDH23 MYO7A
30 auditory neuropathy, autosomal dominant, 1 10.4 GJB2 OTOF
31 deafness, autosomal recessive 7 10.4 GJB2 MT-RNR1 TMC1
32 deafness, autosomal dominant 22 10.4 COCH MYO15A MYO7A
33 auditory neuropathy spectrum disorder 10.4 MT-RNR1 MYO7A OTOF
34 deafness, autosomal recessive 12 10.4 CDH23 GJB2 MYO7A
35 usher syndrome, type if 10.3 CDH23 MYO7A
36 vohwinkel syndrome 10.3 GJB2 GJB6
37 deafness, autosomal dominant 11 10.3 MYO15A MYO7A POU4F3
38 deafness, autosomal recessive 1a 10.3 GJB2 GJB3 GJB6 OTOF
39 usher syndrome, type ic 10.3 CDH23 MYO15A MYO7A
40 peripheral vertigo 10.3 COCH RTEL1 SLC26A4
41 dfnb1 10.3 GJB2 GJB6 MYO7A OTOF
42 deafness, autosomal recessive 2 10.3 GJB2 MYO15A MYO7A OTOF
43 deafness, autosomal recessive 26 10.3 CDH23 GJB2 OTOF SLC26A4
44 deafness, autosomal dominant 36 10.3 GJB2 MT-RNR1 SLC26A4 TMC1
45 deafness, autosomal dominant 48 10.3 MYO15A MYO7A
46 deafness, autosomal dominant 9 10.3 COCH STRC
47 mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma 10.3 GJB2 GJB3
48 autosomal dominant nonsyndromic deafness 10.3 COCH MYO7A POU4F3 TMC1
49 deafness, autosomal recessive 23 10.2 CDH23 GJB2 GJB6 MYO7A SLC26A4
50 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2

Comorbidity relations with Auditory System Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Auditory System Disease:



Diseases related to Auditory System Disease

Symptoms & Phenotypes for Auditory System Disease

UMLS symptoms related to Auditory System Disease:


hyperacusis, tinnitus, snoring, earache, sore throat, coughing, vertigo/dizziness, equilibration disorder, plugged feeling

MGI Mouse Phenotypes related to Auditory System Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 CDH23 GJB6 HSPA4 MYO15A MYO7A OTOF
2 hearing/vestibular/ear MP:0005377 9.8 CDH23 COCH GJB2 GJB6 KCNQ4 MYO15A
3 nervous system MP:0003631 9.5 CDH23 GJB2 GJB6 HSPA4 KCNQ4 MYO15A

Drugs & Therapeutics for Auditory System Disease

Drugs for Auditory System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 498)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 4,Phase 3,Phase 2 58001-44-8 5280980
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
3
Halofantrine Approved Phase 4 69756-53-2 37393
4
Silver sulfadiazine Approved, Vet_approved Phase 4,Not Applicable 22199-08-2 441244
5
Lansoprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 103577-45-3 3883
6
Dexlansoprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 138530-94-6, 103577-45-3 9578005
7
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 616-91-1 12035
8
Montelukast Approved Phase 4,Phase 3,Not Applicable 158966-92-8 5281040
9
Histamine Approved, Investigational Phase 4,Phase 3,Not Applicable 51-45-6 774
10
Sodium Citrate Approved, Investigational Phase 4,Phase 2,Not Applicable 68-04-2
11
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 113775-47-6 68602 5311068
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
14
Cisplatin Approved Phase 4,Phase 1,Phase 2,Not Applicable 15663-27-1 441203 84093 2767
15
Dimenhydrinate Approved Phase 4,Phase 3 523-87-5 441281
16
Glycerol Approved, Investigational Phase 4,Phase 3,Phase 2 56-81-5 753
17
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 85721-33-1 2764
18
carbamide peroxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-43-6
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 437-38-7 3345
20
Morphine Approved, Investigational Phase 4 57-27-2 5288826
21
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
22
Cefdinir Approved Phase 4,Phase 2,Phase 3 91832-40-5 6915944
23 Strawberry Approved Phase 4
24
Betahistine Approved, Investigational Phase 4,Not Applicable 5638-76-6 2366
25
Caffeine Approved Phase 4,Not Applicable 58-08-2 2519
26
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
27
Prilocaine Approved Phase 4 721-50-6 4906
28
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
29
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
30
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
31
Ethanol Approved Phase 4,Phase 3,Phase 1,Not Applicable 64-17-5 702
32
Thymol Approved Phase 4 89-83-8 6989
33
Phenol Approved, Experimental Phase 4,Not Applicable 108-95-2 996
34
Dopamine Approved Phase 4,Not Applicable 62-31-7, 51-61-6 681
35
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
36
Calcium Carbonate Approved, Investigational Phase 4,Phase 2 471-34-1
37
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
38
Tocopherol Approved, Investigational Phase 4,Phase 2 1406-66-2 14986
39
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
40
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 302-25-0
41
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2921-57-5
42
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
43
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
44
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
45
Ofloxacin Approved Phase 4,Phase 3,Phase 1 82419-36-1 4583
46
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1 100986-85-4 149096
47
Citalopram Approved Phase 4 59729-33-8 2771
48
Norepinephrine Approved Phase 4 51-41-2 439260
49
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
50
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826

Interventional clinical trials:

(show top 50) (show all 1294)
# Name Status NCT ID Phase Drugs
1 Amoxicillin Clavulanate in Treatment of Acute Otitis Media Unknown status NCT00299455 Phase 4 amoxicillin-clavulanate;Placebo
2 Silicone Gel to Improve Scar in Microtia Patients Unknown status NCT02518035 Phase 4 Silicone Gel
3 Evaluation of Benefit for Treatment of Single Sided Deafness (SSD) Between Two Bone Conduction Prosthetic Devices; Osseointegrated Implant Versus Maxilla Anchored Removable Oral Appliance ("SoundBite") Unknown status NCT01933386 Phase 4
4 Evaluation of the Effectiveness of Bone-anchored Hearing Aids (Baha) Unknown status NCT01264510 Phase 4
5 Customized Acoustic Stimulation for Long Term Medical Benefit for the Relief of Tinnitus and Hyperacusis Unknown status NCT00730834 Phase 4
6 Bilateral Cochlear Implant Benefit in Young Children Unknown status NCT00424307 Phase 4
7 The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children Unknown status NCT00393159 Phase 4
8 Relationship Between Auto NRT and Behavioural T & C Levels With the Nucleus Freedom Cochlear Implant Unknown status NCT00331539 Phase 4
9 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Unknown status NCT02379754 Phase 4 Gentamicins
10 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4 Contrast agent
11 Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy Completed NCT01244126 Phase 4 Intranasal fentanyl;morphine IM;IV morphine
12 Pneumococcal Vaccines Early and in Combination Completed NCT01174849 Phase 4 Synflorix;Prevenar13;COMBO
13 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4 Lansoprazole;Placebo
14 A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media Completed NCT00645112 Phase 4 cefdinir (Omnicef);azithromycin
15 A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media Completed NCT00644943 Phase 4 cefdinir (Omnicef);amoxicillin
16 Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children Completed NCT00539149 Phase 4 Amoxycillin;Placebo equivalent to amoxycillin
17 Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis Completed NCT00525551 Phase 4 Acetylcysteine;Placebo (NaCl)
18 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
19 A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children Completed NCT00189462 Phase 4 Montelukast
20 Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®) Completed NCT00419380 Phase 4 dornase alfa (Pulmozyme®)
21 Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace Tablets Completed NCT02718846 Phase 4 Meniace;Isobide
22 Efficacy of Local Overpressure Treatment for Meniere's Disease Completed NCT00831688 Phase 4
23 Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy Completed NCT00160238 Phase 4 Betahistine 24 mg bid (Betaserc)
24 Sildenafil For Meniere's Disease Completed NCT00145483 Phase 4 Sildenafil
25 Effect of Caffeine Intake in Vestibular Function Completed NCT02825199 Phase 4
26 Nitrous Oxide Treatment for Tinnitus Completed NCT03365011 Phase 4 Nitrous oxide gas for inhalation;Placebo gas for inhalation
27 Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream Completed NCT02266160 Phase 4 EMLA cream 5%
28 The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea Completed NCT02062333 Phase 4 Dexmedetomidine;esmolol
29 Acoustic Coordinated Reset (CR®) Neuromodulation for the Treatment of Chronic Tonal Tinnitus ("RESET Real Life") Completed NCT01435317 Phase 4
30 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4 Dexamethasone Phosphate
31 Deanxit and Rivotril in Tinnitus Patients Completed NCT00841230 Phase 4 Deanxit;Lactose placebo
32 Phase Out in Tinnitus Patients Completed NCT00833950 Phase 4
33 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
34 Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal Completed NCT00765635 Phase 4 drops intilation (Taponoto ® );drops intilation (Otocerum®);drops intilation (Placebo)
35 Tinnitus Treatment by Structured Cognitive Behavioral Therapy Completed NCT00719940 Phase 4
36 Bilateral Benefit in Adult Users of the HiRes 90K Bionic Ear System Completed NCT00205881 Phase 4
37 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) Completed NCT01800747 Phase 4
38 Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo Completed NCT02253524 Phase 4 Dimenhydrinate;Metoclopramide
39 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
40 Diaphragmatic Movement Before and After Stellate Ganglion Block : A Ultrasonographic Study Completed NCT01054378 Phase 4
41 Effect of Stellate Ganglion Block on Meniere's Disease Completed NCT01574313 Phase 4 0.25mg, fludiazine;25mg cephadol@ (diphenidol);200mg kentons@ (tocopherol nicotinate).
42 Use of Biodesign® Otologic Graft in Canal Wall Down Mastoidectomy: A Prospective, Randomized Trial Recruiting NCT03902938 Phase 4
43 Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children Recruiting NCT02935374 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate;Macrolide
44 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease Recruiting NCT02530931 Phase 4 Gadolinium
45 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4 Gadoteric acid
46 The Study of Wuling Capsule in Treatment Chronic Tinnitus Recruiting NCT03674853 Phase 4 Wuling Capsule;Oryzanol
47 Treating Hearing Loss to Improve Mood and Cognition in Older Adults Recruiting NCT03321006 Phase 4 Duloxetine
48 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
49 Lidoderm Patch (Lidocaine 5%) for Tinnitus Treatment Recruiting NCT02750969 Phase 4
50 Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children Recruiting NCT02653742 Phase 4 Ketorolac;Fentanyl

Search NIH Clinical Center for Auditory System Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: ear diseases

Genetic Tests for Auditory System Disease

Anatomical Context for Auditory System Disease

MalaCards organs/tissues related to Auditory System Disease:

42
Testes, Bone, Brain, Cortex, Liver, Eye, Bone Marrow

Publications for Auditory System Disease

Articles related to Auditory System Disease:

(show top 50) (show all 88)
# Title Authors Year
1
Clinical Study on Middle Ear Diseases in Children with Orofacial Clefts. ( 29644162 )
2018
2
Screening of genes associated with inflammatory responses in the endolymphatic sac reveals underlying mechanisms for autoimmune inner ear diseases. ( 30210597 )
2018
3
Zebrafish models of human eye and inner ear diseases. ( 28129854 )
2017
4
Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015). ( 27855527 )
2017
5
Chronological changes in microbial profiles in external and middle ear diseases: a 20-year study in Korea. ( 27878589 )
2017
6
Role of CT Mastoids in the Diagnosis and Surgical Management of Chronic Inflammatory Ear Diseases. ( 28239591 )
2017
7
Finite element analysis of auditory characteristics in patients with middle ear diseases. ( 28498081 )
2017
8
Ear diseases and factors associated with ear infections among the elderly attending hospital in Arar city, Northern Saudi Arabia. ( 29038714 )
2017
9
Nanomedicine for Inner Ear Diseases: A Review of Recent In Vivo Studies. ( 29130038 )
2017
10
Chronic cerebrospinal venous insufficiency as a cause of inner ear diseases. ( 27846752 )
2016
11
Usefulness of multislice-CT using multiplanar reconstruction in the preoperative assessment of the ossicular lesions in the middle ear diseases. ( 26386497 )
2016
12
Surgical Management of Ear Diseases in Rabbits. ( 26611929 )
2016
13
Prevalence of ear diseases in the children of Delhi. ( 25883066 )
2015
14
Profile of ear diseases among elderly patients in Sagamu, south-western Nigeria. ( 23829127 )
2013
15
Association of smoking or tobacco use with ear diseases among men: a retrospective study. ( 22471960 )
2012
16
External and middle ear diseases: radiological diagnosis based on clinical signs and symptoms. ( 22695997 )
2012
17
Ear diseases and other risk factors for hearing impairment among adults: an epidemiological study. ( 22934931 )
2012
18
The prevalence of middle ear diseases among 7- to 13-year-old primary school students in Yozgat province. ( 23427512 )
2012
19
Ear diseases among secondary school students in Xi'an, China: the role of portable audio device use, insomnia and academic stress. ( 21649930 )
2011
20
Frequency-specific hearing results after surgery for chronic ear diseases. ( 21949578 )
2011
21
Ear diseases in children presenting at Nepal Medical College Teaching Hospital. ( 22808806 )
2011
22
Nanotechnology and the treatment of inner ear diseases. ( 25363748 )
2011
23
Communication routes between intracranial spaces and inner ear: function, pathophysiologic importance and relations with inner ear diseases. ( 19410125 )
2009
24
Pattern of ear diseases in rural school children: experiences of free health camps in Nepal. ( 19560217 )
2009
25
Auditory function in women with autoimmune inner ear diseases and their offspring. ( 19804914 )
2009
26
The evaluation of the tensor veli palatini muscle function with electromyography in chronic middle ear diseases. ( 17851675 )
2008
27
Viral etiology for inner ear diseases: proven, unproven, unlikely. ( 18235205 )
2008
28
Influence of chronic middle ear diseases on gustatory function: an electrogustometric study. ( 17195745 )
2007
29
How to reliably evaluate middle ear diseases? Comparison of different methods of post-processing based on multislice computed tomography examination. ( 17364362 )
2007
30
Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases. ( 17453719 )
2007
31
A comparative evaluation of ear diseases in children of higher versus lower socioeconomic status. ( 16375776 )
2006
32
Intratympanic steroid therapy for inner ear diseases, a review of the literature. ( 16724210 )
2006
33
Ear diseases in elderly hospital patients in Nigeria. ( 15860483 )
2005
34
Self-curing controlled release systems for steroids. Application of prednisolone-based polymeric systems to ear diseases. ( 15603826 )
2005
35
Cell therapy for inner ear diseases. ( 15853667 )
2005
36
Gustatory function in chronic inflammatory middle ear diseases. ( 15933535 )
2005
37
Round-window anatomical considerations in intratympanic drug therapy for inner-ear diseases. ( 16419685 )
2005
38
Application of cell therapy to inner ear diseases. ( 15078068 )
2004
39
Review of diagnostic imaging of ear diseases in the dog and cat. ( 12718347 )
2003
40
Clinical experience with caroverine in inner ear diseases. ( 11885656 )
2002
41
Hearing impairment and ear diseases among children of school entry age in rural South India. ( 12049823 )
2002
42
Ear diseases and hearing in the Thai elderly population. Part I. A comparative study of the accuracy of diagnosis and treatment by general practitioners vs ENT specialists. ( 12188380 )
2002
43
Ear diseases and hearing in the Thai elderly population. part II. A one year follow-up study. ( 12188381 )
2002
44
COCH5B2 is a target antigen of anti-inner ear antibodies in autoimmune inner ear diseases. ( 11568667 )
2001
45
Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases. ( 11270490 )
2001
46
What inner ear diseases cause benign paroxysmal positional vertigo? ( 10894413 )
2000
47
Use of ototopical antibiotics in treating 3 common ear diseases. ( 10828818 )
2000
48
What you need to know--hearing loss and inner ear diseases--can they be cured? ( 10361491 )
1999
49
Influence of the gas exchange function through the middle ear mucosa on the development of sniff-induced middle ear diseases. ( 9591546 )
1998
50
Clinical applicability of the sweep frequency measuring apparatus for diagnosis of middle ear diseases. ( 9657598 )
1998

Variations for Auditory System Disease

ClinVar genetic disease variations for Auditory System Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(7;19)(q32;q13.1)dn Translocation Pathogenic
2 46;XY;inv(2)(q11.2q24.2)dn inversion Uncertain significance
3 subset of 47 genes:TBX1 GRCh37/hg19 22q11.21(chr22: 18894835-21505417) copy number loss Pathogenic GRCh37 Chromosome 22, 18894835: 21505417

Expression for Auditory System Disease

Search GEO for disease gene expression data for Auditory System Disease.

Pathways for Auditory System Disease

Pathways related to Auditory System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.79 GJB2 GJB3 GJB6

GO Terms for Auditory System Disease

Cellular components related to Auditory System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 9.33 GJB2 GJB3 GJB6
2 stereocilium tip GO:0032426 9.26 STRC TMC1
3 connexin complex GO:0005922 9.13 GJB2 GJB3 GJB6
4 stereocilium GO:0032420 8.92 CDH23 MYO15A MYO7A STRC

Biological processes related to Auditory System Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inner ear receptor cell stereocilium organization GO:0060122 9.49 CDH23 MYO7A
2 auditory receptor cell stereocilium organization GO:0060088 9.48 MYO7A STRC
3 sensory perception of sound GO:0007605 9.47 CDH23 COCH GJB2 GJB6 KCNQ4 MYO15A
4 detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9.46 STRC TMC1
5 inner ear morphogenesis GO:0042472 9.46 KCNQ4 MYO15A MYO7A POU4F3
6 sensory perception of light stimulus GO:0050953 9.43 CDH23 MYO7A
7 cell communication GO:0007154 9.43 GJB2 GJB3 GJB6
8 inner ear auditory receptor cell differentiation GO:0042491 9.4 MYO7A POU4F3
9 inner ear receptor cell differentiation GO:0060113 9.37 MYO7A POU4F3
10 inner ear development GO:0048839 9.35 GJB2 GJB6 MYO7A POU3F4 POU4F3
11 equilibrioception GO:0050957 9.32 CDH23 MYO7A

Molecular functions related to Auditory System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.62 GJB2 GJB3

Sources for Auditory System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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