Aliases & Classifications for Auditory System Disease

MalaCards integrated aliases for Auditory System Disease:

Name: Auditory System Disease 12 15 17
Ear Diseases 43 71
Ear and Mastoid Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2742
ICD9CM 34 388.9
MeSH 43 D004427
NCIt 49 C26757
SNOMED-CT 67 25906001
UMLS 71 C0013447

Summaries for Auditory System Disease

Disease Ontology : 12 A sensory system disease that is characterized by auditory dysfunction located in the auditory system.

MalaCards based summary : Auditory System Disease, also known as ear diseases, is related to inner ear disease and branchiootic syndrome 1, and has symptoms including hyperacusis, tinnitus and snoring. An important gene associated with Auditory System Disease is MIR96 (MicroRNA 96), and among its related pathways/superpathways is Gap junction trafficking. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include auditory system, bone and testes, and related phenotypes are behavior/neurological and hearing/vestibular/ear

Wikipedia : 74 The auditory system is the sensory system for the sense of hearing. It includes both the sensory organs... more...

Related Diseases for Auditory System Disease

Diseases related to Auditory System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 inner ear disease 34.3 SLC26A4 MYO7A MT-RNR1 MIR96 KCNQ4 GJB6
2 branchiootic syndrome 1 31.5 TMC1 SLC26A4 OTOF MYO7A GJB2 CDH23
3 chronic purulent otitis media 31.4 DHRS2 COCH
4 otosclerosis 31.2 SLC26A4 OTOF MYO15A MT-RNR1 GJB2 COCH
5 sensorineural hearing loss 31.1 TMC1 SLC26A4 POU3F4 PCDH15 OTOF MYO7A
6 cogan syndrome 31.1 GJB2 COCH
7 labyrinthitis 30.8 SLC26A4 MYO7A GJB2
8 keratitis, hereditary 30.4 MYO7A GJB6 GJB2
9 peripheral vertigo 30.4 SLC26A4 MYO7A KCNQ4 GJB2 COCH
10 vestibular disease 30.2 SLC26A4 POU3F4 PCDH15 OTOF MYO7A MYO15A
11 external ear disease 12.5
12 autoimmune inner ear disease 12.4
13 middle ear disease 12.4
14 otitis externa 11.2
15 mastoiditis 11.1
16 adhesive otitis media 11.1
17 superior semicircular canal dehiscence 11.1
18 deafness, autosomal dominant 1 10.8 MYO7A MYO15A GJB2
19 nonsyndromic hearing loss and deafness, dfna3 10.7 GJB6 GJB2
20 deafness, autosomal recessive 77 10.7 SLC26A4 GJB2 CDH23
21 deafness, autosomal recessive 3 10.7 MYO7A MYO15A GJB2
22 nonsyndromic hearing loss and deafness, dfnb1 10.7 GJB6 GJB3 GJB2
23 hypotrichosis-deafness syndrome 10.7 GJB3 GJB2
24 deafness, autosomal dominant 56 10.7 SLC26A4 GJB2 COCH
25 pseudoainhum 10.7 GJB6 GJB3 GJB2
26 deafness, autosomal dominant 67 10.7 OTOF MIR96 GJB2
27 deafness, autosomal recessive 93 10.7 TMC1 OTOF GJB2
28 congenital cytomegalovirus 10.7 MT-RNR1 GJB6 GJB2
29 deafness, autosomal dominant 3b 10.7 GJB6 GJB3 GJB2
30 usher syndrome, type ih 10.7 PCDH15 MYO7A CDH23
31 auditory neuropathy spectrum disorder 10.7 OTOF MYO7A MT-RNR1
32 purulent labyrinthitis 10.7 GJB6 GJB2
33 knuckle pads 10.7 GJB6 GJB3 GJB2
34 deafness, autosomal recessive 10.7 PCDH15 OTOF GJB3 GJB2
35 viral labyrinthitis 10.7 GJB6 GJB2
36 usher syndrome, type iiib 10.7 PCDH15 MYO7A EPRS1
37 nonsyndromic deafness 10.7 PCDH15 MYO15A KCNQ4 GJB2
38 usher syndrome, type ik 10.7 PCDH15 CDH23
39 usher syndrome, type ij 10.7 PCDH15 MYO7A CDH23
40 keratoderma, palmoplantar, with deafness 10.7 GJB6 GJB3 GJB2
41 deafness, autosomal recessive 91 10.7 GJB3 GJB2 COCH
42 deafness, autosomal recessive 8 10.7 TMC1 OTOF MYO15A GJB2
43 deafness, autosomal recessive 79 10.7 TMC1 MYO15A GJB2
44 otitis media 10.7
45 deafness, autosomal recessive 48 10.7 TMC1 PCDH15 MYO7A
46 deafness, autosomal dominant 41 10.7 SLC26A4 KCNQ4 GJB2 CDH23
47 deafness, autosomal recessive 49 10.7 POU3F4 MYO15A GJB2
48 deafness, autosomal recessive 22 10.7 OTOF MYO15A CDH23
49 deafness, autosomal recessive 63 10.7 TMC1 MYO7A MYO15A
50 deafness, autosomal recessive 13 10.7 TMC1 CDH23

Comorbidity relations with Auditory System Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Auditory System Disease:



Diseases related to Auditory System Disease

Symptoms & Phenotypes for Auditory System Disease

UMLS symptoms related to Auditory System Disease:


hyperacusis, tinnitus, snoring, earache, sore throat, coughing, vertigo/dizziness, equilibration disorder, plugged feeling

MGI Mouse Phenotypes related to Auditory System Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 CDH23 ERCC6 GJB6 HSPA4 MYO15A MYO7A
2 hearing/vestibular/ear MP:0005377 9.8 CDH23 COCH ERCC6 GJB2 GJB3 GJB6
3 nervous system MP:0003631 9.44 CDH23 ERCC6 GJB2 GJB6 HSPA4 KCNQ4

Drugs & Therapeutics for Auditory System Disease

Drugs for Auditory System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
carbamide peroxide Approved Phase 3 124-43-6
4 Vaccines Phase 3
5 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
6 Immunologic Factors Phase 3
7 Anesthetics Phase 3
8 Ancrod Approved, Investigational Phase 1, Phase 2 9046-56-4
9
Ciprofloxacin Approved, Investigational Phase 1, Phase 2 85721-33-1 2764
10
Dipivefrin Approved Phase 1, Phase 2 52365-63-6 3105
11
Simethicone Approved Phase 2 8050-81-5
12
Calcium carbonate Approved, Investigational Phase 2 471-34-1
13
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
14
Cisplatin Approved Phase 1, Phase 2 15663-27-1 2767 441203 84093
15
Cysteine Approved, Nutraceutical Phase 1, Phase 2 52-90-4 5862
16 Pharmaceutical Solutions Phase 2
17 Fibrinolytic Agents Phase 1, Phase 2
18 Anticoagulants Phase 1, Phase 2
19 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
20 Anti-Bacterial Agents Phase 1, Phase 2
21 Gastrointestinal Agents Phase 2
22 Hormones Phase 2
23 Hormone Antagonists Phase 2
24 Antineoplastic Agents, Hormonal Phase 2
25 Antiemetics Phase 2
26 glucocorticoids Phase 2
27 Anti-Inflammatory Agents Phase 2
28 Dermatologic Agents Phase 2
29 Emollients Phase 2
30 Calcium, Dietary Phase 2
31 Anti-Infective Agents Phase 1, Phase 2
32 Interleukin 1 Receptor Antagonist Protein Phase 2
33 Antirheumatic Agents Phase 2
34 Respiratory System Agents Phase 1, Phase 2
35 Antidotes Phase 1, Phase 2
36 Expectorants Phase 1, Phase 2
37 Antioxidants Phase 1, Phase 2
38 Antiviral Agents Phase 1, Phase 2
39 Protective Agents Phase 1, Phase 2
40 N-monoacetylcystine Phase 1, Phase 2
41
Calcium Nutraceutical Phase 2 7440-70-2 271
42
Histamine Approved, Investigational Phase 1 51-45-6 774
43
Phenylephrine Approved Phase 1 59-42-7 6041
44
Pseudoephedrine Approved Phase 1 90-82-4 7028
45
Ephedrine Approved Phase 1 299-42-3 9294
46 Neurotransmitter Agents Phase 1
47 Adrenergic alpha-Agonists Phase 1
48 Cardiotonic Agents Phase 1
49 Central Nervous System Stimulants Phase 1
50 Nasal Decongestants Phase 1

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Use of Biodesign® Otologic Graft in Canal Wall Down Mastoidectomy: A Prospective, Randomized Trial Recruiting NCT03902938 Phase 4
2 PneuMum: A Randomised Controlled Trial of Pneumococcal Polysaccharide Vaccination for Aboriginal and Torres Strait Islander Mothers to Protect Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
3 Efficacy and Safety of AM-111 in the Treatment of Acute Inner Ear Hearing Loss Completed NCT02561091 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
4 A Prospective, Randomized, Double Blind, Placebo-controlled, Multicenter, Phase 3 Efficacy and Safety Study of OTO-104 Given as a Single Intratympanic Injection in Subjects With Unilateral Meniere's Disease Recruiting NCT03664674 Phase 3 OTO-104;Placebo
5 Double Blind, Placebo-controlled, Randomized Clinical Trial to Evaluate the Efficacy and Safety of a Transtympanic Treatment of Tinnitus With Caroverine Suspended NCT01174979 Phase 3 Caroverin
6 Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment Terminated NCT02809118 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
7 An Open-label Study of the Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
8 Double-blind, Randomized, Placebo-controlled Study on Efficacy, Safety and Tolerability of Ancrod in Patients With Sudden Sensorineural Hearing Loss (SSHL) Completed NCT01621256 Phase 1, Phase 2 Ancrod;Saline solution
9 Bioequivalence of Ciprofloxacin 0.3%: a Randomized, Multicenter, Parallel, Comparative Study on the Safety and Efficacy of Ciprofloxacin 0.3% in a Standard Solution or Foam Solution, in Patients With Acute External Otitis. Completed NCT00872209 Phase 1, Phase 2 0.3% Ciprofloxacin Ear Drops;0.3% Ciprofloxacin Foam Otic Cipro
10 Safety and Efficacy of Once-Daily Dosing of Ciprodexa Otic Foam (Ciprofloxacin 0.3% and Dexamethasone 0.1% Otic Foam) Compared to Twice-Daily Dosing of Ciprodex (0.3% Ciprofloxacin and Dexamethasone 0.1% Otic Suspension) in Patients With Acute Otitis Externa Completed NCT01359098 Phase 2 Ciprodex Otic Suspension;Ciprodexa Otic Foam
11 Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro (0.3% Ciprofloxacin Otic Foam) Compared to Twice-Daily Dosing of Ciloxan (0.3% Ciprofloxacin Otic Solution) in Patients With Acute External Otitis Completed NCT01157819 Phase 2 0.3% Ciprofloxacin Ear Drops;FoamOtic Cipro
12 A Phase I/II Open-label Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
13 A Pilot Study of the Effect of Simethicone in Adult Subjects With a Common Cold on Eustachian Tube Dysfunction Completed NCT01312038 Phase 2 Simethicone;Placebo
14 Intratympanic N-Acetylcysteine (NAC) Injections for Prevention of Cisplatin-induced Ototoxicity in Head and Neck Cancer Patients: A Multi-centre Phase II Randomized Controlled Trial. Recruiting NCT04291209 Phase 1, Phase 2 N-Acetyl Cysteine
15 A Phase II Placebo Controlled Study of the Effects of Anakinra (Kineret) in Subjects With Corticosteroid-Resistant Meniere's Disease (CR-MD) and Corticosteroid-Resistant Autoimmune Inner Ear Disease Disease (CR-AIED) Recruiting NCT03587701 Phase 2 Anakinra 100Mg/0.67Ml Inj Syringe (Period 1);Placebo injection (Period 1);Anakinra 100Mg/0.67Ml Inj Syringe (Period 2);Placebo injection (Period 2)
16 Safety and Efficacy of Intratympanically Delivered Golimumab for Stabilization of Hearing in Patients With Autoimmune Inner Ear Disease: An Open-label Proof-of-concept Clinical Trial Terminated NCT01526174 Phase 1, Phase 2 Golimumab
17 An Open-label, Single-dose, Pharmacokinetic Study of SENS-218 in Healthy Adult, Caucasian Subjects. Completed NCT02772796 Phase 1 SENS-218
18 A Randomised Double Blind, Multiple Dose, Pharmacokinetic and Safety Study of SENS 401 in Healthy Subjects Completed NCT03071003 Phase 1 SENS-401;Placebo
19 Middle Ear Pressure Regulation in Health and Disease -- Gas Supply, Demand and Middle Ear Gas Balance -- Specific Aim 2 Completed NCT01925729 Phase 1 pseudoephedrine;Oxymetazoline
20 Physiotherapy in Vestibular Disorders Unknown status NCT02746770
21 The Lolland-Falster Health Study Unknown status NCT02482896
22 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417
23 Testing the Effectivness and Safety of the Wondertip Unknown status NCT03019380
24 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
25 Comparison of Clinical and Game-based Rehabilitation for Balance Impairments and Gaze Dysfunction in Clients With Vestibular Disorders Unknown status NCT02134444
26 Interest of the Cone-beam Computed Tomography in the Imagery of the Middle Ear Completed NCT02896764
27 Long-term Stability and Survival Rates of a Novel Oticon Medical Bone Conduction Device Implant Completed NCT01738490
28 The Effects of the Erchonia Hearing Laser on Word Recognition in Hearing Impaired Individuals Clinical Study Protocol Completed NCT00787189
29 To Evaluate Incidence of Acute Otitis Media in Children Aged < 6 Years in Five East European Countries Completed NCT01365390
30 The Effect of Activity Treatment on Vestibular Rehabilitation of Patients With Chronic Unilateral Peripheral Vestibular Disorders Completed NCT04425928
31 Polish Mother and Child Cohort Study (REPRO_PL).Follow up of the Children. Completed NCT01861548
32 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults With Clinically Diagnosed Chronic Otitis Media With Effusion and/or Eustachian Tube Dysfunction Completed NCT01251432
33 Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation. Completed NCT03171181
34 Addressing Early Childhood Hearing Loss in Rural Alaska: A Community Randomized Trial Completed NCT03662256
35 Clinical Study of Endolymphatic Sac Drainage With or Without Steroids for Intractable Meniere's Disease Completed NCT00500474
36 Clinical Trial Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium Completed NCT01483937
37 Influence of Central Versus Peripheral Vestibular Stimulation on Recovery Outcomes in Patients With Peripheral Vestibular Disorders Recruiting NCT04010435
38 Implantation of the HiRes90K™ Advantage Cochlear Implant With HiFocus™ Mid-Scala and Development of a Combined Electric and Acoustic Stimulation Technology in Adults With Partial Deafness Recruiting NCT02189798
39 Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts Recruiting NCT03297736
40 Balloon Dilation of the Eustachian Tube in Children: a Randomized Side-controlled Clinical Trial Recruiting NCT03499015
41 Feasibility of Stereotactic Image Guidance on the Lateral Skull Base Recruiting NCT03852329
42 Benefits of the HiResolution Bionic Ear System in Adults With Asymmetric Hearing Loss Active, not recruiting NCT02811549
43 Computerized Game-based Vestibular Rehabilitation: Assessment of Feasibility and Motor Learning Active, not recruiting NCT03589859
44 Gas Supply, Demand and Middle Ear Gas Balance -- Project 1, Specific Aim 4, Protocol 3 Active, not recruiting NCT01974726
45 Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) Not yet recruiting NCT04328181
46 Evaluation of Hearing Preservation in Adults With Partial Low-Frequency Hearing Implanted With the HiFocus™ Mid-Scala Electrode Terminated NCT01959152
47 The Use of the PoNS™ Device in the Treatment of Blunt and Blast Induced Vestibular Disorders Withdrawn NCT01771575

Search NIH Clinical Center for Auditory System Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Sulfacetamide
Sulfacetamide Sodium

Cochrane evidence based reviews: ear diseases

Genetic Tests for Auditory System Disease

Anatomical Context for Auditory System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Auditory System Disease:

19
Auditory System

MalaCards organs/tissues related to Auditory System Disease:

40
Bone, Testes, Eye, Pons, Bone Marrow, Brain, Skin

Publications for Auditory System Disease

Articles related to Auditory System Disease:

(show top 50) (show all 814)
# Title Authors PMID Year
1
Expression of aquaporins in inner ear disease. 61
31593306 2020
2
Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media. 61
32488375 2020
3
Smartphone-based spectral imaging otoscope: System development and preliminary study for evaluation of its potential as a mobile diagnostic tool. 61
32141237 2020
4
The first description of cholesteatoma by Hippocrate. 61
32162060 2020
5
Availability of audiological evaluation for the differential diagnosis of clinical otosclerosis. 61
32370914 2020
6
Electrophysiological and inner ear MRI findings in patients with bilateral vestibulopathy. 61
32036409 2020
7
Eyes in Ears: A Miniature Steerable Digital Endoscope for Trans-Nasal Diagnosis of Middle Ear Disease. 61
32458223 2020
8
Removal of biofilm is essential for long-term ventilation tube retention. 61
32432137 2020
9
A 3D deep supervised densely network for small organs of human temporal bone segmentation in CT images. 61
32004922 2020
10
How effect is educational counseling prior to middle ear surgery for patients with both middle ear diseases and consistent tinnitus? 61
32049560 2020
11
Inner-Ear Disorders Presenting with Air-Bone Gaps: A Review. 61
32401207 2020
12
[In vivo dynamic changes of inner ear guinea pigs with 9.4 T esla MRI]. 61
32306636 2020
13
Community Triage of Otology Patients Using a Store-and-Forward Telemedicine Device: A Feasibility Study. 61
32200652 2020
14
High Human Papillomavirus DNA loads in Inflammatory Middle Ear Diseases. 61
32197385 2020
15
Practical aspects of inner ear gene delivery for research and clinical applications. 61
32204962 2020
16
Endoscopic Removal of Huge Cholesterol Granuloma in the Maxillary Sinus Confused With Odontogenic Keratocyst. 61
31895863 2020
17
Quality in middle ear surgery - a critical position determination. 61
32384566 2020
18
[OTOLARYNGOLOGY, HEAD AND NECK SURGERY - VARIETY OF PATHOLOGIES AND MANAGEMENT OPTIONS]. 61
32048483 2020
19
[Voxel-based morphometry study of the brain structures in patients with congenital hereditary hearing loss]. 61
32074743 2020
20
The Physiologic Role of Corticosteroids in Menière's Disease: An Update on Glucocorticoid-mediated Pathophysiology and Corticosteroid Inner Ear Distribution. 61
31821251 2020
21
OtoMatch: Content-based eardrum image retrieval using deep learning. 61
32413096 2020
22
CEDRA: A Tool to Help Consumers Assess Risk for Ear Disease. 61
30946136 2019
23
[The research progress of keratin's roles in the pathology of middle ear cholesteatoma]. 61
31795552 2019
24
Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases. 61
31070081 2019
25
Subversion of host immune responses by otopathogens during otitis media. 61
31075181 2019
26
Opportunities and challenging issues of nanomaterials in otological fields: an occupational health perspective. 61
31609676 2019
27
Cochlear Glucocorticoid Receptor and Serum Corticosterone Expression in a Rodent Model of Noise-induced Hearing Loss: Comparison of Timing of Dexamethasone Administration. 61
31477769 2019
28
Poly-Lactic Acid-Based Biopolymer Formulations Are Safe for Sustained Intratympanic Dexamethasone Delivery. 61
31295207 2019
29
The future of otology. 61
31462337 2019
30
Automated diagnosis of ear disease using ensemble deep learning with a big otoendoscopy image database. 61
31272902 2019
31
Comparison of 3- vs 2-Dimensional Endoscopy Using Eye Tracking and Assessment of Cognitive Load Among Surgeons Performing Endoscopic Ear Surgery. 61
31343675 2019
32
miR‑10b‑3p, miR‑8112 and let‑7j as potential biomarkers for autoimmune inner ear diseases. 61
31115534 2019
33
Therapeutic Effect of Intratympanic Injection of Dexamethasone plus Hyaluronic Acid on Patients with Meniere's disease. 61
31384587 2019
34
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease. 61
31086039 2019
35
Detecting middle ear fluid using smartphones. 61
31092691 2019
36
Risk Factors for Tinnitus in 37,692 Patients Followed in General Practices in Germany. 61
30870350 2019
37
Using Machine Learning to Predict Sensorineural Hearing Loss Based on Perilymph Micro RNA Expression Profile. 61
30833669 2019
38
Pathogen reservoir hypothesis investigated by analyses of the adenotonsillar and middle ear microbiota. 61
30599284 2019
39
Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology. 61
30871195 2019
40
Contributing factors to high prevalence of hearing impairment in the Elias Motsoaledi Local Municipal area, South Africa: A rural perspective. 61
30843412 2019
41
Preschool children in Danish out-of-hours primary care: a one-year descriptive study of face-to-face consultations. 61
30808295 2019
42
[Study on the relationship between age-related hearing loss and cognitive impairment]. 61
30776862 2019
43
[Clinical features and treatment of multi-canal benign paroxysmal positional vertigo]. 61
32027319 2019
44
The Impact of using the term "Diabetic Ear" for the patients with Skull Base Osteomyelitis. 61
30697101 2019
45
Defining the Inflammatory Microenvironment in the Human Cochlea by Perilymph Analysis: Toward Liquid Biopsy of the Cochlea. 61
31293504 2019
46
Evaluation of a transtympanic delivery system in Mus musculus for extended release steroids. 61
29329746 2019
47
Sleep Deprivation Modifies Noise-Induced Cochlear Injury Related to the Stress Hormone and Autophagy in Female Mice. 61
31849600 2019
48
Is oval window transport a royal gate for nanoparticle delivery to vestibule in the inner ear? 61
29499347 2019
49
30-day unplanned readmission rate in otolaryngology patients: A population-based study in Thuringia, Germany. 61
31622434 2019
50
Immunohistochemical localization of Nrf2 in the human cochlea. 61
29981724 2018

Variations for Auditory System Disease

Expression for Auditory System Disease

Search GEO for disease gene expression data for Auditory System Disease.

Pathways for Auditory System Disease

Pathways related to Auditory System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.79 GJB6 GJB3 GJB2

GO Terms for Auditory System Disease

Cellular components related to Auditory System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 9.33 GJB6 GJB3 GJB2
2 connexin complex GO:0005922 9.13 GJB6 GJB3 GJB2
3 stereocilium GO:0032420 8.92 PCDH15 MYO7A MYO15A CDH23

Biological processes related to Auditory System Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.97 SLC26A4 KCNQ4 GJB6 GJB3 GJB2
2 locomotory behavior GO:0007626 9.7 PCDH15 MYO15A CDH23
3 inner ear morphogenesis GO:0042472 9.65 MYO7A MYO15A KCNQ4
4 cell communication GO:0007154 9.58 GJB6 GJB3 GJB2
5 vesicle transport along actin filament GO:0030050 9.56 MYO7A MYO15A
6 auditory receptor cell stereocilium organization GO:0060088 9.55 PCDH15 MYO7A
7 detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9.54 TMC1 PCDH15
8 photoreceptor cell maintenance GO:0045494 9.54 PCDH15 ERCC6 CDH23
9 inner ear auditory receptor cell differentiation GO:0042491 9.51 PCDH15 MYO7A
10 inner ear receptor cell stereocilium organization GO:0060122 9.5 PCDH15 MYO7A CDH23
11 gap junction assembly GO:0016264 9.49 GJB6 GJB2
12 cell communication by electrical coupling GO:0010644 9.46 GJB6 GJB2
13 gap junction-mediated intercellular transport GO:1990349 9.43 GJB6 GJB2
14 sensory perception of light stimulus GO:0050953 9.43 PCDH15 MYO7A CDH23
15 sensory perception of sound GO:0007605 9.4 TMC1 SLC26A4 POU3F4 PCDH15 OTOF MYO7A
16 inner ear development GO:0048839 9.35 POU3F4 PCDH15 MYO7A GJB6 GJB2
17 equilibrioception GO:0050957 9.33 PCDH15 MYO7A CDH23

Molecular functions related to Auditory System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.33 PCDH15 MYO7A ERCC6
2 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.96 GJB6 GJB2
3 gap junction channel activity GO:0005243 8.8 GJB6 GJB3 GJB2

Sources for Auditory System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....