MCID: ARC003
MIFTS: 32

Auricular Cancer

Categories: Cancer diseases, Ear diseases

Aliases & Classifications for Auricular Cancer

MalaCards integrated aliases for Auricular Cancer:

Name: Auricular Cancer 12 15
Ear Neoplasms 43 71
Malignant Tumor of Ear 12
Cancer of Ear Auricle 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5101
MeSH 43 D004428
UMLS 71 C0013449 C0751094

Summaries for Auricular Cancer

MalaCards based summary : Auricular Cancer, also known as ear neoplasms, is related to acquired hemangioma and lymphangiosarcoma, and has symptoms including earache An important gene associated with Auricular Cancer is STAB1 (Stabilin 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Remifentanil and Propofol have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and myeloid.

Related Diseases for Auricular Cancer

Graphical network of the top 20 diseases related to Auricular Cancer:



Diseases related to Auricular Cancer

Symptoms & Phenotypes for Auricular Cancer

UMLS symptoms related to Auricular Cancer:


earache

Drugs & Therapeutics for Auricular Cancer

Drugs for Auricular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 3 132875-61-7 60815
2
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
3 Anesthetics Phase 3
4 Narcotics Phase 3
5 Anesthetics, General Phase 3
6 Analgesics, Opioid Phase 3
7 Pharmaceutical Solutions Phase 3
8 Central Nervous System Depressants Phase 3
9 Hypnotics and Sedatives Phase 3
10 Anesthetics, Intravenous Phase 3
11 Analgesics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Impact of Adding Remifentanil to Propofol on the Conditions of the Diagnostic Panendoscopy of the Upper Airway Under General Anesthesia With Tubeless Spontaneous Ventilation. Completed NCT02093143 Phase 3 Remifentanil

Search NIH Clinical Center for Auricular Cancer

Cochrane evidence based reviews: ear neoplasms

Genetic Tests for Auricular Cancer

Anatomical Context for Auricular Cancer

MalaCards organs/tissues related to Auricular Cancer:

40
Bone, Skin, Myeloid, Pancreas, Breast

Publications for Auricular Cancer

Articles related to Auricular Cancer:

(show all 23)
# Title Authors PMID Year
1
Endoscopic excision of a tympanic paraganglioma: Training the next generation of ear surgeons. 61
29516061 2017
2
[The use of the Surgitron radiowave scalpel for the surgical treatment of external ear neoplasms]. 61
27367341 2016
3
A case of sensorineural hearing loss involving a fibroepithelial polyp of the middle ear. 61
25701460 2015
4
Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone. 61
26027747 2015
5
Transcanal endoscopic treatment of benign middle ear neoplasms. 61
23377229 2013
6
[Middle ear adenoma]. 61
20436986 2009
7
[Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms]. 61
17668798 2007
8
[Malignant neoplasms of external and middle ear]. 61
16095097 2005
9
[Middle ear carcinoma]. 61
9644865 1998
10
[Computer tomography in the diagnosis of ear neoplasms]. 61
9334016 1997
11
Tumors of the external ear. 61
7642978 1995
12
[Glandular ear neoplasms]. 61
7644206 1995
13
[Basal cell and basosquamous carcinomas of the external ear. Immunohistochemical study]. 61
7817742 1994
14
[Topographic and anatomic markers of the temporal pyramidal bone and their role in the surgical treatment of ear neoplasms]. 61
8036751 1993
15
[Methodological aspects of radiotherapy in the treatment of ear neoplasms]. 61
2048244 1991
16
Carcinoid tumour of the middle ear. A morphological and immunohistochemical study with comments on histogenesis and differential diagnosis. 61
2481299 1989
17
Middle ear neoplasms showing adenomatous and neuroendocrine components. 61
2715695 1989
18
Carcinoid tumour of the middle ear associated with systemic symptoms. 61
3585164 1987
19
Rhabdomyosarcoma of the middle ear: a wolf in sheep's clothing. 61
7375237 1980
20
[Double skin cancer coexisting with chronic myeloid leukemia]. 61
272812 1977
21
Auricular cancer. Some surgical and pathologic considerations. 61
4942609 1971
22
[On the angiographic determination of ear neoplasms]. 61
5697315 1968
23
[A case of auricular cancer]. 61
5182276 1966

Variations for Auricular Cancer

Expression for Auricular Cancer

Search GEO for disease gene expression data for Auricular Cancer.

Pathways for Auricular Cancer

Pathways related to Auricular Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 VEGFC CXCL6 CXCL5 CXCL1 CCL7 CCL20
2
Show member pathways
13.14 MMP1 CXCL6 CXCL5 CXCL1 CCL7 CCL20
3
Show member pathways
13.12 VEGFC CXCL6 CXCL5 CXCL1 CCL7 CCL20
4
Show member pathways
13.01 VEGFC CXCL6 CXCL5 CXCL1 CCL7 CCL20
5
Show member pathways
12.6 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17
6
Show member pathways
11.77 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17
7 11.7 VEGFC CXCL6 CXCL5 CXCL1 CCL20
8 11.52 MMP1 CXCL6 CXCL5 CXCL1 CCL20
9 11.5 CXCL1 CCL20 CCL17
10
Show member pathways
11.5 MMP1 CXCL6 CXCL5 CXCL1 CCL7 CCL20
11 11.1 MMP1 LYVE1
12 10.77 VEGFC CXCL6 CXCL5 CXCL1 CCL7 CCL20

GO Terms for Auricular Cancer

Cellular components related to Auricular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 VEGFC LRRC15 CXCL6 CXCL5 CXCL1 CCL7
2 extracellular region GO:0005576 9.28 VEGFC PI3 MMP1 CXCL6 CXCL5 CXCL1

Biological processes related to Auricular Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.01 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17
2 immune response GO:0006955 9.85 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17
3 cell-cell signaling GO:0007267 9.8 STAB1 CXCL6 CXCL5 CCL7 CCL20 CCL17
4 inflammatory response GO:0006954 9.8 STAB1 CXCL6 CXCL5 CXCL1 CCL7 CCL20
5 positive regulation of cell migration GO:0030335 9.77 PDPN LRRC15 CCL7
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL7 CCL20 CCL17
7 cellular response to lipopolysaccharide GO:0071222 9.74 CXCL6 CXCL5 CXCL1
8 defense response GO:0006952 9.73 CXCL6 CXCL5 CXCL1
9 cellular response to tumor necrosis factor GO:0071356 9.72 CCL7 CCL20 CCL17
10 cellular response to interferon-gamma GO:0071346 9.7 CCL7 CCL20 CCL17
11 cell chemotaxis GO:0060326 9.69 CXCL6 CXCL5 CCL20
12 cellular response to interleukin-1 GO:0071347 9.67 CCL7 CCL20 CCL17
13 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.65 CXCL6 CXCL5 CXCL1
14 monocyte chemotaxis GO:0002548 9.63 CCL7 CCL20 CCL17
15 chemotaxis GO:0006935 9.63 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17
16 lymphocyte chemotaxis GO:0048247 9.61 CCL7 CCL20 CCL17
17 amino acid transmembrane transport GO:0003333 9.58 SLC38A3 PDPN
18 leukocyte chemotaxis GO:0030595 9.58 CXCL6 CXCL5 CXCL1
19 neutrophil chemotaxis GO:0030593 9.43 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17
20 chemokine-mediated signaling pathway GO:0070098 9.1 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17

Molecular functions related to Auricular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 CXCL6 CXCL1 CCL7 CCL20 CCL17
2 CCR chemokine receptor binding GO:0048020 9.33 CCL7 CCL20 CCL17
3 amino acid transmembrane transporter activity GO:0015171 9.32 SLC38A3 PDPN
4 hyaluronic acid binding GO:0005540 9.26 STAB1 LYVE1
5 chemokine activity GO:0008009 9.1 CXCL6 CXCL5 CXCL1 CCL7 CCL20 CCL17

Sources for Auricular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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