AUTS6
MCID: ATS371
MIFTS: 28

Autism 6 (AUTS6)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autism 6

MalaCards integrated aliases for Autism 6:

Name: Autism 6 57
Autism, Susceptibility to, 6 57 13 72
Autism Susceptibility 6 57
Auts6 57

Classifications:



External Ids:

UMLS 72 C1836271

Summaries for Autism 6

OMIM : 57 Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; 608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006). For a discussion of genetic heterogeneity of autism, see 209850. (609378)

MalaCards based summary : Autism 6, also known as autism, susceptibility to, 6, is related to autism and mild pre-eclampsia. An important gene associated with Autism 6 is AUTS6 (Autism, Susceptibility To, 6). The drugs Guaifenesin and Codeine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast.

Related Diseases for Autism 6

Graphical network of the top 20 diseases related to Autism 6:



Diseases related to Autism 6

Symptoms & Phenotypes for Autism 6

Clinical features from OMIM:

609378

Drugs & Therapeutics for Autism 6

Drugs for Autism 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2
Codeine Approved, Illicit Phase 4 76-57-3 5284371
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4 Central Nervous System Depressants Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Cyclooxygenase Inhibitors Phase 4
7 Narcotics Phase 4
8 Analgesics Phase 4
9 Respiratory System Agents Phase 4
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
13 Analgesics, Opioid Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Antitussive Agents Phase 4
16 Antirheumatic Agents Phase 4
17
Melatonin Approved, Nutraceutical, Vet_approved Phase 2 73-31-4 896
18 Antioxidants Phase 2
19 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Security of Combined Analgesia (Opioid and Anti-inflammatory Agent) to Control Pain in Children Seen in the Emergency Department for a Trauma of a Limb Completed NCT01189773 Phase 4 ibuprofen and codeine
2 The Development of Autistic Children Based on Mother´s Response in Autism Behavior Checklist Completed NCT00725556 Phase 1, Phase 2
3 Melatonin Dose-effect Relation in Childhood Autism Completed NCT01780883 Phase 2 melatonin;Placebo

Search NIH Clinical Center for Autism 6

Genetic Tests for Autism 6

Anatomical Context for Autism 6

MalaCards organs/tissues related to Autism 6:

41
Brain, Testes, Breast, Temporal Lobe

Publications for Autism 6

Articles related to Autism 6:

(show all 35)
# Title Authors PMID Year
1
Genetic/familial high-risk assessment: breast and ovarian, version 1.2014. 71
25190698 2014
2
Clinical genetics evaluation in identifying the etiology of autism spectrum disorders: 2013 guideline revisions. 71
23519317 2013
3
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. 71
20466091 2010
4
Hypothesis: dysregulation of methylation of brain-expressed genes on the X chromosome and autism spectrum disorders. 8
18698615 2008
5
High density SNP association study of a major autism linkage region on chromosome 17. 8
17376794 2007
6
Evidence for multiple loci from a genome scan of autism kindreds. 8
16880825 2006
7
ITGB3 shows genetic and expression interaction with SLC6A4. 8
16721604 2006
8
Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism. 8
16616719 2006
9
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. 8
15995945 2005
10
Effects of updating linkage evidence across subsets of data: reanalysis of the autism genetic resource exchange data set. 8
15729670 2005
11
Evidence for sex-specific risk alleles in autism spectrum disorder. 8
15467983 2004
12
Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic population. 8
14708029 2004
13
A genomewide screen of 345 families for autism-susceptibility loci. 8
13680528 2003
14
Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. 8
11920155 2002
15
Genetics of autism: complex aetiology for a heterogeneous disorder. 8
11733747 2001
16
A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p. 8
11481586 2001
17
Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. 8
10686565 2000
18
A genomic screen of autism: evidence for a multilocus etiology. 8
10417292 1999
19
5-HTTLPR variants not associated with autistic spectrum disorders. 8
10369890 1999
20
Serotonin transporter (5-HTT) gene variants associated with autism? 8
9361027 1997
21
Evidence of linkage between the serotonin transporter and autistic disorder. 8
9152989 1997
22
Autism: towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. 8
8655659 1996
23
Platelet serotonin, a possible marker for familial autism. 8
2037549 1991
24
Elevated blood serotonin in autistic probands and their first-degree relatives. 8
2793785 1989
25
A combined study of MEG and pico-Tesla TMS on children with autism disorder. 38
27875942 2016
26
New Perspective on Impact of Folic Acid Supplementation during Pregnancy on Neurodevelopment/Autism in the Offspring Children - A Systematic Review. 38
27875541 2016
27
Enhanced integration of motion information in children with autism. 38
25948250 2015
28
Assessing the health, functional characteristics, and health needs of youth attending a noncategorical transition support program. 38
22921138 2012
29
Mitochondrial dysfunction in autism. 38
21119085 2010
30
Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism. 38
19879307 2010
31
Functional characteristics of disruptive behavior in developmentally disabled children with and without autism. 38
16134028 2005
32
Weight and leptin changes among risperidone-treated youths with autism: 6-month prospective data. 38
15169706 2004
33
Randomized trial of intensive early intervention for children with pervasive developmental disorder. 38
10934569 2000
34
Association of tuberous sclerosis of temporal lobes with autism and atypical autism. 38
9033466 1997
35
The child who does not talk. 38
13750138 1961

Variations for Autism 6

Expression for Autism 6

Search GEO for disease gene expression data for Autism 6.

Pathways for Autism 6

GO Terms for Autism 6

Biological processes related to Autism 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.32 SOD1 LEP
2 regulation of blood pressure GO:0008217 9.26 SOD1 LEP
3 response to nutrient levels GO:0031667 9.16 SOD1 LEP
4 placenta development GO:0001890 8.96 SOD1 LEP
5 positive regulation of cytokine production GO:0001819 8.62 SOD1 LEP

Sources for Autism 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....