MCID: ATM078
MIFTS: 18

Autoimmune Addison Disease

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Autoimmune Addison Disease

MalaCards integrated aliases for Autoimmune Addison Disease:

Name: Autoimmune Addison Disease 43
Autoimmune Primary Adrenal Insufficiency 70
Addison's Disease Due to Autoimmunity 70
Autoimmune Addison's Disease 43
Classic Addison Disease 43
Primary Addison Disease 43
Autoimmune Adrenalitis 43

Classifications:



External Ids:

UMLS 70 C0271737 C2103602

Summaries for Autoimmune Addison Disease

MedlinePlus Genetics : 43 Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands. As a result, the production of several hormones is disrupted, which affects many body systems.The signs and symptoms of autoimmune Addison disease can begin at any time, although they most commonly begin between ages 30 and 50. Common features of this condition include extreme tiredness (fatigue), nausea, decreased appetite, and weight loss. In addition, many affected individuals have low blood pressure (hypotension), which can lead to dizziness when standing up quickly; muscle cramps; and a craving for salty foods. A characteristic feature of autoimmune Addison disease is abnormally dark areas of skin (hyperpigmentation), especially in regions that experience a lot of friction, such as the armpits, elbows, knuckles, and palm creases. The lips and the inside lining of the mouth can also be unusually dark. Because of an imbalance of hormones involved in development of sexual characteristics, women with this condition may lose their underarm and pubic hair.Other signs and symptoms of autoimmune Addison disease include low levels of sugar (hypoglycemia) and sodium (hyponatremia) and high levels of potassium (hyperkalemia) in the blood. Affected individuals may also have a shortage of red blood cells (anemia) and an increase in the number of white blood cells (lymphocytosis), particularly those known as eosinophils (eosinophilia).Autoimmune Addison disease can lead to a life-threatening adrenal crisis, characterized by vomiting, abdominal pain, back or leg cramps, and severe hypotension leading to shock. The adrenal crisis is often triggered by a stressor, such as surgery, trauma, or infection.Individuals with autoimmune Addison disease or their family members can have another autoimmune disorder, most commonly autoimmune thyroid disease or type 1 diabetes.

MalaCards based summary : Autoimmune Addison Disease, also known as autoimmune primary adrenal insufficiency, is related to hypoadrenocorticism, familial and autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia. An important gene associated with Autoimmune Addison Disease is CCL5 (C-C Motif Chemokine Ligand 5). The drugs Cosyntropin and Hormones have been mentioned in the context of this disorder.

Related Diseases for Autoimmune Addison Disease

Diseases related to Autoimmune Addison Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 hypoadrenocorticism, familial 11.3
2 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 11.1
3 autoimmune polyendocrine syndrome, type ii 11.1
4 autoimmune disease 10.4
5 autoimmune polyendocrine syndrome 10.4
6 graves' disease 10.4
7 hypoparathyroidism 10.3
8 thyroiditis 10.3
9 premature ovarian failure 7 10.3
10 autoimmune polyendocrine syndrome type 1 10.2
11 primary adrenal insufficiency 10.2
12 hashimoto thyroiditis 10.2
13 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
14 lipoid congenital adrenal hyperplasia 10.2
15 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
16 candidiasis 10.2
17 gastritis 10.2
18 atrophic gastritis 10.2
19 thymoma, familial 10.1
20 thymoma 10.1
21 pernicious anemia 10.1
22 rickets 10.1
23 hypothyroidism 10.1
24 chronic mucocutaneous candidiasis 10.1
25 hypoglycemia 10.1
26 myasthenia gravis 10.0
27 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
28 limbic encephalitis 10.0
29 premature menopause 10.0
30 cerebrovascular disease 10.0
31 paraneoplastic neurologic disorders 10.0
32 myoclonus 10.0
33 membranoproliferative glomerulonephritis 10.0
34 glomerulonephritis 10.0
35 renal cell carcinoma, nonpapillary 9.9
36 dowling-degos disease 1 9.9
37 sarcoidosis 1 9.9
38 adrenocortical carcinoma, hereditary 9.9
39 celiac disease 1 9.9
40 type 1 diabetes mellitus 9.9
41 immune deficiency disease 9.9
42 proteasome-associated autoinflammatory syndrome 1 9.9
43 hyperprolactinemia 9.9
44 adrenal cortical carcinoma 9.9
45 metabolic acidosis 9.9
46 immunoglobulin alpha deficiency 9.9
47 familial glucocorticoid deficiency 9.9
48 polymyositis 9.9
49 hyperandrogenism 9.9
50 diarrhea 9.9

Graphical network of the top 20 diseases related to Autoimmune Addison Disease:



Diseases related to Autoimmune Addison Disease

Symptoms & Phenotypes for Autoimmune Addison Disease

Drugs & Therapeutics for Autoimmune Addison Disease

Drugs for Autoimmune Addison Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cosyntropin Approved Phase 4 16960-16-0 16129617
2 Hormones Phase 4
3 Hormone Antagonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Revival of Autochthonous Adrenocortical Stem Cells in Autoimmune Addison's Disease Completed NCT01371526 Phase 4 depot tetracosactide

Search NIH Clinical Center for Autoimmune Addison Disease

Genetic Tests for Autoimmune Addison Disease

Anatomical Context for Autoimmune Addison Disease

Publications for Autoimmune Addison Disease

Articles related to Autoimmune Addison Disease:

(show all 22)
# Title Authors PMID Year
1
Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis. 61
32915988 2020
2
Residual Corticosteroid Production in Autoimmune Addison Disease. 61
32392298 2020
3
Natural History of Adrenal Steroidogenesis in Autoimmune Addison's Disease Following Diagnosis and Treatment. 61
32300791 2020
4
The altered circadian pattern of basal insulin requirements - an early marker of autoimmune polyendocrine syndromes in type 1 diabetes mellitus. 61
32597157 2020
5
Sex-Specific Risk of Cardiovascular Disease in Autoimmune Addison Disease-A Population-Based Cohort Study. 61
30608542 2019
6
Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report. 61
29949817 2018
7
Elevated serum RANTES chemokine levels in autoimmune Addison disease. 61
29498364 2018
8
Cytokine Autoantibody Screening in the Swedish Addison Registry Identifies Patients With Undiagnosed APS1. 61
29069385 2018
9
Clinical and Immunological Characteristics of Autoimmune Addison Disease: A Nationwide Swedish Multicenter Study. 61
27870550 2017
10
[Adrenal insufficiency of the adult]. 61
27016277 2016
11
Addison Disease: The First Presentation of the Condition May be at Autopsy. 61
31239896 2016
12
Diagnosis and classification of Addison's disease (autoimmune adrenalitis). 61
24424183 2014
13
Autoimmune Addison disease: pathophysiology and genetic complexity. 61
22290360 2012
14
Autoimmunity: autoimmune Addison disease and premature ovarian failure. 61
21750509 2011
15
Myasthenia gravis and autoimmune Addison disease in a patient with thymoma. 61
19808197 2009
16
Primary hyperaldosteronism associated with vitiligo vulgaris and autoimmune hypothyroidism. 61
17496738 2007
17
Paraneoplastic neurologic syndrome and autoimmune Addison disease in a patient with thymoma. 61
15654180 2005
18
Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity. 61
12137862 2002
19
Mitochondrial DNA deletion with Kearns Sayre syndrome in a child with Addison disease. 61
9727847 1998
20
Immunoprecipitation assay for autoantibodies to steroid 21-hydroxylase in autoimmune adrenal diseases. 61
7882511 1995
21
[Bone complications of fluorotherapy: influence of androgen deficiency]. 61
2130762 1990
22
The adrenoleukomyeloneuropathy complex: expression in four generations. 61
6258103 1981

Variations for Autoimmune Addison Disease

Expression for Autoimmune Addison Disease

Search GEO for disease gene expression data for Autoimmune Addison Disease.

Pathways for Autoimmune Addison Disease

GO Terms for Autoimmune Addison Disease

Sources for Autoimmune Addison Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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