MCID: ATM103
MIFTS: 20

Autoimmune Atherosclerosis

Categories: Immune diseases

Aliases & Classifications for Autoimmune Atherosclerosis

MalaCards integrated aliases for Autoimmune Atherosclerosis:

Name: Autoimmune Atherosclerosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040096

Summaries for Autoimmune Atherosclerosis

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by a build up of plaque in the arteries.

MalaCards based summary : Autoimmune Atherosclerosis is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and vulvovaginitis. An important gene associated with Autoimmune Atherosclerosis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Th17 cell differentiation and Allograft rejection. Related phenotype is mortality/aging.

Related Diseases for Autoimmune Atherosclerosis

Diseases related to Autoimmune Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.6 IL10 HSPD1 FOXP3
2 vulvovaginitis 10.2 IL10 HSPD1
3 trachoma 10.2 IL10 HSPD1
4 atherosclerosis susceptibility 10.2
5 acute disseminated encephalomyelitis 10.2 IL10 HSPD1
6 hypersplenism 10.1 FOXP3 CD4
7 leprosy 3 10.1 IL10 HSPD1
8 testicular disease 10.1 IL10 HSPD1
9 discoid lupus erythematosus 10.1 IL10 APOH
10 transverse myelitis 10.1 IL10 APOH
11 reactive arthritis 10.1 IL10 HSPD1
12 chronic graft versus host disease 10.1 IL10 CD4
13 apple allergy 10.1 IL10 FOXP3
14 autoimmune disease of eyes, ear, nose and throat 10.1 IL10 FOXP3
15 autoimmune optic neuritis 10.0 IL10 FOXP3
16 primary bacterial infectious disease 10.0 IL10 HSPD1
17 autoimmune pancreatitis 10.0 IL10 FOXP3
18 bacterial infectious disease 10.0 IL10 HSPD1
19 human immunodeficiency virus infectious disease 10.0 IL10 CD4
20 tropical spastic paraparesis 10.0 IL10 FOXP3
21 chlamydia 10.0 IL10 HSPD1
22 autoimmune disease of central nervous system 10.0 IL10 FOXP3
23 upper respiratory tract disease 10.0 IL10 FOXP3
24 food allergy 9.9 IL10 FOXP3
25 retinal artery occlusion 9.9 APOH ACE
26 cutaneous leishmaniasis 9.9 IL10 FOXP3
27 visceral leishmaniasis 9.9 IL10 FOXP3
28 intermittent claudication 9.9 APOH ACE
29 kawasaki disease 9.9 IL10 HSPD1
30 relapsing-remitting multiple sclerosis 9.9 IL10 FOXP3
31 heart valve disease 9.9 APOH ACE
32 melkersson-rosenthal syndrome 9.8 CD4 ACE
33 acquired immunodeficiency syndrome 9.8 IL10 CD4
34 intestinal disease 9.8 IL10 FOXP3
35 mixed connective tissue disease 9.8 IL10 HSPD1 APOH
36 endocarditis 9.8 IL10 HSPD1 APOH
37 behcet syndrome 9.8 IL10 HSPD1 APOH
38 extrinsic cardiomyopathy 9.7 IL10 ACE
39 rheumatic heart disease 9.7 IL10 ACE
40 omenn syndrome 9.7 IL10 FOXP3
41 pyelonephritis 9.7 IL10 ACE
42 rheumatic disease 9.7 IL10 APOH
43 mitral valve disease 9.7 IL10 ACE
44 adult respiratory distress syndrome 9.7 IL10 ACE
45 pulmonary edema 9.7 IL10 ACE
46 mycobacterium tuberculosis 1 9.7 IL10 HSPD1
47 autoimmune disease of musculoskeletal system 9.7 IL10 FOXP3 APOH
48 immune system disease 9.7 IL10 FOXP3 APOH
49 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.6 IL10 FOXP3 CD4
50 chagas disease 9.5 IL10 ACE

Graphical network of the top 20 diseases related to Autoimmune Atherosclerosis:



Diseases related to Autoimmune Atherosclerosis

Symptoms & Phenotypes for Autoimmune Atherosclerosis

MGI Mouse Phenotypes related to Autoimmune Atherosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.1 ACE APOH CD4 FOXP3 HSPD1 IL10

Drugs & Therapeutics for Autoimmune Atherosclerosis

Search Clinical Trials , NIH Clinical Center for Autoimmune Atherosclerosis

Genetic Tests for Autoimmune Atherosclerosis

Anatomical Context for Autoimmune Atherosclerosis

Publications for Autoimmune Atherosclerosis

Articles related to Autoimmune Atherosclerosis:

# Title Authors PMID Year
1
Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis. 38
30543922 2019
2
Autoimmune atherosclerosis in 3D: How it develops, how to diagnose and what to do. 38
26979271 2016
3
Is atherosclerosis an autoimmune disease? 38
24642015 2014
4
Aspirin may do wonders by the induction of immunological self-tolerance against autoimmune atherosclerosis. 38
22070887 2012
5
Identification of immunoreactive epitopes of the Porphyromonas gingivalis heat shock protein in periodontitis and atherosclerosis. 38
21241301 2011

Variations for Autoimmune Atherosclerosis

Expression for Autoimmune Atherosclerosis

Search GEO for disease gene expression data for Autoimmune Atherosclerosis.

Pathways for Autoimmune Atherosclerosis

GO Terms for Autoimmune Atherosclerosis

Cellular components related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 HSPD1 CD4 APOH

Biological processes related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.71 IL10 FOXP3 CD4
2 negative regulation of inflammatory response GO:0050728 9.52 IL10 FOXP3
3 negative regulation of tumor necrosis factor production GO:0032720 9.48 IL10 FOXP3
4 negative regulation of T cell proliferation GO:0042130 9.43 IL10 FOXP3
5 B cell proliferation GO:0042100 9.4 IL10 HSPD1
6 negative regulation of interleukin-6 production GO:0032715 9.37 IL10 FOXP3
7 negative regulation of interferon-gamma production GO:0032689 9.32 IL10 FOXP3
8 cytokine production GO:0001816 9.26 FOXP3 CD4
9 response to organic substance GO:0010033 9.21 IL10
10 response to glucocorticoid GO:0051384 9.19 IL10
11 response to activity GO:0014823 9.16 IL10
12 positive regulation of T cell activation GO:0050870 9.16 HSPD1 CD4
13 positive regulation of macrophage activation GO:0043032 8.96 IL10 HSPD1
14 T cell activation GO:0042110 8.8 HSPD1 FOXP3 CD4

Sources for Autoimmune Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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