MCID: ATM103
MIFTS: 22

Autoimmune Atherosclerosis

Categories: Immune diseases

Aliases & Classifications for Autoimmune Atherosclerosis

MalaCards integrated aliases for Autoimmune Atherosclerosis:

Name: Autoimmune Atherosclerosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040096

Summaries for Autoimmune Atherosclerosis

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by a build up of plaque in the arteries.

MalaCards based summary : Autoimmune Atherosclerosis is related to retinal artery occlusion and ischemic optic neuropathy. An important gene associated with Autoimmune Atherosclerosis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Allograft rejection and Th2 Differentiation Pathway. Affiliated tissues include heart, t cells and eye, and related phenotypes are mortality/aging and reproductive system

Related Diseases for Autoimmune Atherosclerosis

Diseases related to Autoimmune Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 retinal artery occlusion 10.1 ACE APOH
2 ischemic optic neuropathy 10.1 ACE APOH
3 intermittent claudication 10.1 ACE APOH
4 heart valve disease 10.1 ACE APOH
5 vulvovaginitis 10.0 HSPD1 IL10
6 trachoma 10.0 HSPD1 IL10
7 acute disseminated encephalomyelitis 10.0 HSPD1 IL10
8 leprosy 3 9.9 HSPD1 IL10
9 testicular disease 9.9 HSPD1 IL10
10 reactive arthritis 9.9 HSPD1 IL10
11 discoid lupus erythematosus 9.9 APOH IL10
12 transverse myelitis 9.9 APOH IL10
13 extrinsic cardiomyopathy 9.9 ACE IL10
14 rheumatic heart disease 9.9 ACE IL10
15 primary bacterial infectious disease 9.9 HSPD1 IL10
16 pyelonephritis 9.9 ACE IL10
17 bacterial infectious disease 9.9 HSPD1 IL10
18 mitral valve disease 9.9 ACE IL10
19 adult respiratory distress syndrome 9.9 ACE IL10
20 chlamydia 9.9 HSPD1 IL10
21 pulmonary edema 9.9 ACE IL10
22 apple allergy 9.9 FOXP3 IL10
23 autoimmune disease of eyes, ear, nose and throat 9.9 FOXP3 IL10
24 autoimmune optic neuritis 9.9 FOXP3 IL10
25 autoimmune pancreatitis 9.9 FOXP3 IL10
26 vascular disease 9.8 ACE APOH HSPD1
27 tropical spastic paraparesis 9.8 FOXP3 IL10
28 kawasaki disease 9.8 HSPD1 IL10
29 autoimmune disease of central nervous system 9.8 FOXP3 IL10
30 chagas disease 9.8 ACE IL10
31 food allergy 9.8 FOXP3 IL10
32 upper respiratory tract disease 9.8 FOXP3 IL10
33 diabetes mellitus 9.8 ACE FOXP3 HSPD1
34 cutaneous leishmaniasis 9.8 FOXP3 IL10
35 visceral leishmaniasis 9.8 FOXP3 IL10
36 mycobacterium tuberculosis 1 9.8 HSPD1 IL10
37 relapsing-remitting multiple sclerosis 9.8 FOXP3 IL10
38 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 FOXP3 IL10
39 rheumatic disease 9.8 APOH IL10
40 atherosclerosis susceptibility 9.8
41 intestinal disease 9.7 FOXP3 IL10
42 omenn syndrome 9.7 FOXP3 IL10
43 nervous system disease 9.7 ACE IL10
44 mixed connective tissue disease 9.7 APOH HSPD1 IL10
45 endocarditis 9.7 APOH HSPD1 IL10
46 arteriosclerosis 9.7 ACE HSPD1 IL10
47 behcet syndrome 9.7 APOH HSPD1 IL10
48 gastrointestinal system disease 9.7 FOXP3 IL10
49 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.6 FOXP3 HSPD1 IL10
50 autoimmune disease of musculoskeletal system 9.6 APOH FOXP3 IL10

Graphical network of the top 20 diseases related to Autoimmune Atherosclerosis:



Diseases related to Autoimmune Atherosclerosis

Symptoms & Phenotypes for Autoimmune Atherosclerosis

MGI Mouse Phenotypes related to Autoimmune Atherosclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.35 ACE APOH FOXP3 HSPD1 IL10
2 reproductive system MP:0005389 8.92 ACE FOXP3 HSPD1 IL10

Drugs & Therapeutics for Autoimmune Atherosclerosis

Search Clinical Trials , NIH Clinical Center for Autoimmune Atherosclerosis

Genetic Tests for Autoimmune Atherosclerosis

Anatomical Context for Autoimmune Atherosclerosis

MalaCards organs/tissues related to Autoimmune Atherosclerosis:

42
Heart, T Cells, Eye

Publications for Autoimmune Atherosclerosis

Articles related to Autoimmune Atherosclerosis:

# Title Authors Year
1
Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis. ( 30543922 )
2018

Variations for Autoimmune Atherosclerosis

Expression for Autoimmune Atherosclerosis

Search GEO for disease gene expression data for Autoimmune Atherosclerosis.

Pathways for Autoimmune Atherosclerosis

GO Terms for Autoimmune Atherosclerosis

Cellular components related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ACE APOH HSPD1 IL10

Biological processes related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.49 FOXP3 IL10
2 T cell activation GO:0042110 9.43 FOXP3 HSPD1
3 negative regulation of tumor necrosis factor production GO:0032720 9.4 FOXP3 IL10
4 negative regulation of T cell proliferation GO:0042130 9.32 FOXP3 IL10
5 B cell proliferation GO:0042100 9.26 HSPD1 IL10
6 response to organic substance GO:0010033 9.18 IL10
7 response to glucocorticoid GO:0051384 9.16 IL10
8 negative regulation of interferon-gamma production GO:0032689 9.16 FOXP3 IL10
9 response to activity GO:0014823 9.07 IL10
10 negative regulation of interleukin-6 production GO:0032715 8.96 FOXP3 IL10
11 positive regulation of macrophage activation GO:0043032 8.62 HSPD1 IL10

Sources for Autoimmune Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....