Autoimmune Atherosclerosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Autoimmune Atherosclerosis

MalaCards integrated aliases for Autoimmune Atherosclerosis:

Name: Autoimmune Atherosclerosis ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040096

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Summaries for Autoimmune Atherosclerosis

Disease Ontology : ¹² An autoimmune disease of cardiovascular system that is characterized by a build up of plaque in the arteries.

MalaCards based summary : Autoimmune Atherosclerosis is related to retinal artery occlusion and ischemic optic neuropathy. An important gene associated with Autoimmune Atherosclerosis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Allograft rejection and Th2 Differentiation Pathway. Affiliated tissues include heart, t cells and eye, and related phenotypes are mortality/aging and reproductive system

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Related Diseases for Autoimmune Atherosclerosis

Diseases related to Autoimmune Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Related Disease	Score	Top Affiliating Genes
1	retinal artery occlusion	10.1	ACE APOH
2	ischemic optic neuropathy	10.1	ACE APOH
3	intermittent claudication	10.1	ACE APOH
4	heart valve disease	10.1	ACE APOH
5	vulvovaginitis	10.0	HSPD1 IL10
6	trachoma	10.0	HSPD1 IL10
7	acute disseminated encephalomyelitis	10.0	HSPD1 IL10
8	leprosy 3	9.9	HSPD1 IL10
9	testicular disease	9.9	HSPD1 IL10
10	reactive arthritis	9.9	HSPD1 IL10
11	discoid lupus erythematosus	9.9	APOH IL10
12	transverse myelitis	9.9	APOH IL10
13	extrinsic cardiomyopathy	9.9	ACE IL10
14	rheumatic heart disease	9.9	ACE IL10
15	primary bacterial infectious disease	9.9	HSPD1 IL10
16	pyelonephritis	9.9	ACE IL10
17	bacterial infectious disease	9.9	HSPD1 IL10
18	mitral valve disease	9.9	ACE IL10
19	adult respiratory distress syndrome	9.9	ACE IL10
20	chlamydia	9.9	HSPD1 IL10
21	pulmonary edema	9.9	ACE IL10
22	apple allergy	9.9	FOXP3 IL10
23	autoimmune disease of eyes, ear, nose and throat	9.9	FOXP3 IL10
24	autoimmune optic neuritis	9.9	FOXP3 IL10
25	autoimmune pancreatitis	9.9	FOXP3 IL10
26	vascular disease	9.8	ACE APOH HSPD1
27	tropical spastic paraparesis	9.8	FOXP3 IL10
28	kawasaki disease	9.8	HSPD1 IL10
29	autoimmune disease of central nervous system	9.8	FOXP3 IL10
30	chagas disease	9.8	ACE IL10
31	food allergy	9.8	FOXP3 IL10
32	upper respiratory tract disease	9.8	FOXP3 IL10
33	diabetes mellitus	9.8	ACE FOXP3 HSPD1
34	cutaneous leishmaniasis	9.8	FOXP3 IL10
35	visceral leishmaniasis	9.8	FOXP3 IL10
36	mycobacterium tuberculosis 1	9.8	HSPD1 IL10
37	relapsing-remitting multiple sclerosis	9.8	FOXP3 IL10
38	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	9.8	FOXP3 IL10
39	rheumatic disease	9.8	APOH IL10
40	atherosclerosis susceptibility	9.8
41	intestinal disease	9.7	FOXP3 IL10
42	omenn syndrome	9.7	FOXP3 IL10
43	nervous system disease	9.7	ACE IL10
44	mixed connective tissue disease	9.7	APOH HSPD1 IL10
45	endocarditis	9.7	APOH HSPD1 IL10
46	arteriosclerosis	9.7	ACE HSPD1 IL10
47	behcet syndrome	9.7	APOH HSPD1 IL10
48	gastrointestinal system disease	9.7	FOXP3 IL10
49	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	9.6	FOXP3 HSPD1 IL10
50	autoimmune disease of musculoskeletal system	9.6	APOH FOXP3 IL10

Graphical network of the top 20 diseases related to Autoimmune Atherosclerosis:

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Symptoms & Phenotypes for Autoimmune Atherosclerosis

MGI Mouse Phenotypes related to Autoimmune Atherosclerosis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	9.35	ACE APOH FOXP3 HSPD1 IL10
2	reproductive system	MP:0005389	8.92	ACE FOXP3 HSPD1 IL10

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Drugs & Therapeutics for Autoimmune Atherosclerosis

Search Clinical Trials , NIH Clinical Center for Autoimmune Atherosclerosis

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Genetic Tests for Autoimmune Atherosclerosis

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Anatomical Context for Autoimmune Atherosclerosis

MalaCards organs/tissues related to Autoimmune Atherosclerosis:

⁴²

Heart, T Cells, Eye

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Publications for Autoimmune Atherosclerosis

Articles related to Autoimmune Atherosclerosis:

#	Title	Authors	Year
1	Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis. ( 30543922 )	Balogh E...Szekanecz Z	2018

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Genes for Autoimmune Atherosclerosis

Genes related to Autoimmune Atherosclerosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	14.85	DISEASES inferred ¹⁵
2	APOH	Apolipoprotein H	Protein Coding	14.75	DISEASES inferred ¹⁵
3	FOXP3	Forkhead Box P3	Protein Coding	14.18	DISEASES inferred ¹⁵
4	IL10	Interleukin 10	Protein Coding	13.28	DISEASES inferred ¹⁵
5	ACE	Angiotensin I Converting Enzyme	Protein Coding	13.14	DISEASES inferred ¹⁵

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Variations for Autoimmune Atherosclerosis

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Expression for Autoimmune Atherosclerosis

Search GEO for disease gene expression data for Autoimmune Atherosclerosis.

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Pathways for Autoimmune Atherosclerosis

Pathways related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ³⁸ ¹ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	12.07	FOXP3 HSPD1 IL10
2	Th2 Differentiation Pathway ⁶⁶	10.62	FOXP3 IL10
3	Microglia Activation During Neuroinflammation: Steady-State Microglia ⁶⁶	10.28	HSPD1 IL10

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GO Terms for Autoimmune Atherosclerosis

Cellular components related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	8.92	ACE APOH HSPD1 IL10

Biological processes related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of inflammatory response	GO:0050728	9.49	FOXP3 IL10
2	T cell activation	GO:0042110	9.43	FOXP3 HSPD1
3	negative regulation of tumor necrosis factor production	GO:0032720	9.4	FOXP3 IL10
4	negative regulation of T cell proliferation	GO:0042130	9.32	FOXP3 IL10
5	B cell proliferation	GO:0042100	9.26	HSPD1 IL10
6	response to organic substance	GO:0010033	9.18	IL10
7	response to glucocorticoid	GO:0051384	9.16	IL10
8	negative regulation of interferon-gamma production	GO:0032689	9.16	FOXP3 IL10
9	response to activity	GO:0014823	9.07	IL10
10	negative regulation of interleukin-6 production	GO:0032715	8.96	FOXP3 IL10
11	positive regulation of macrophage activation	GO:0043032	8.62	HSPD1 IL10

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Sources for Autoimmune Atherosclerosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia