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MCID: ATM103
MIFTS: 22

Autoimmune Atherosclerosis

Categories: Cardiovascular diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Autoimmune Atherosclerosis

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MalaCards integrated aliases for Autoimmune Atherosclerosis:

Name: Autoimmune Atherosclerosis 12 15

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040096
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Summaries for Autoimmune Atherosclerosis

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Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by a build up of plaque in the arteries.

MalaCards based summary : Autoimmune Atherosclerosis is related to amyotrophic lateral sclerosis 10 with or without frontotemporal dementia and vulvovaginitis. An important gene associated with Autoimmune Atherosclerosis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Allograft rejection and Th2 Differentiation Pathway. Affiliated tissues include heart, eye and t cells.

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Related Diseases for Autoimmune Atherosclerosis

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Diseases related to Autoimmune Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 10.1 APOH ENSG00000264813
2 vulvovaginitis 10.1 HSPD1 IL10
3 trachoma 10.1 HSPD1 IL10
4 acute disseminated encephalomyelitis 10.1 HSPD1 IL10
5 testicular disease 10.1 HSPD1 IL10
6 discoid lupus erythematosus 10.1 APOH IL10
7 transverse myelitis 10.1 APOH IL10
8 reactive arthritis 10.1 HSPD1 IL10
9 leprosy 3 10.0 HSPD1 IL10
10 apple allergy 10.0 FOXP3 IL10
11 primary bacterial infectious disease 10.0 HSPD1 IL10
12 autoimmune disease of eyes, ear, nose and throat 10.0 FOXP3 IL10
13 bacterial infectious disease 10.0 HSPD1 IL10
14 autoimmune optic neuritis 10.0 FOXP3 IL10
15 autoimmune pancreatitis 10.0 FOXP3 IL10
16 chlamydia 10.0 HSPD1 IL10
17 tropical spastic paraparesis 10.0 FOXP3 IL10
18 autoimmune disease of central nervous system 10.0 FOXP3 IL10
19 food allergy 10.0 FOXP3 IL10
20 upper respiratory tract disease 10.0 FOXP3 IL10
21 cutaneous leishmaniasis 10.0 FOXP3 IL10
22 autoimmune disease of the nervous system 10.0 FOXP3 IL10
23 visceral leishmaniasis 10.0 FOXP3 IL10
24 retinal artery occlusion 10.0 ACE APOH
25 relapsing-remitting multiple sclerosis 10.0 FOXP3 IL10
26 ischemic optic neuropathy 10.0 ACE APOH
27 intermittent claudication 10.0 ACE APOH
28 loeffler syndrome 10.0 ACE ENSG00000264813
29 uveoparotid fever 10.0 ACE ENSG00000264813
30 fiedler's myocarditis 10.0 ACE ENSG00000264813
31 orthostatic proteinuria 10.0 ACE ENSG00000264813
32 malignant essential hypertension 10.0 ACE ENSG00000264813
33 heart valve disease 10.0 ACE APOH
34 subdural empyema 10.0 ACE ENSG00000264813
35 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0 FOXP3 IL10
36 kawasaki disease 9.9 HSPD1 IL10
37 hypersensitivity reaction type iv disease 9.9 ACE ENSG00000264813
38 intestinal disease 9.9 FOXP3 IL10
39 mixed connective tissue disease 9.9 APOH HSPD1 IL10
40 endocarditis 9.9 APOH HSPD1 IL10
41 behcet syndrome 9.9 APOH HSPD1 IL10
42 extrinsic cardiomyopathy 9.9 ACE IL10
43 rheumatic heart disease 9.9 ACE IL10
44 pyelonephritis 9.9 ACE IL10
45 mitral valve disease 9.9 ACE IL10
46 adult respiratory distress syndrome 9.9 ACE IL10
47 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 FOXP3 HSPD1 IL10
48 arteries, anomalies of 9.9 ACE ENSG00000264813
49 omenn syndrome 9.9 FOXP3 IL10
50 pulmonary edema 9.9 ACE IL10

Graphical network of the top 20 diseases related to Autoimmune Atherosclerosis:



Diseases related to Autoimmune Atherosclerosis
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Symptoms & Phenotypes for Autoimmune Atherosclerosis

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Drugs & Therapeutics for Autoimmune Atherosclerosis

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Search Clinical Trials , NIH Clinical Center for Autoimmune Atherosclerosis

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Genetic Tests for Autoimmune Atherosclerosis

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Anatomical Context for Autoimmune Atherosclerosis

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MalaCards organs/tissues related to Autoimmune Atherosclerosis:

41
Heart, Eye, T Cells
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Publications for Autoimmune Atherosclerosis

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Articles related to Autoimmune Atherosclerosis:

# Title Authors Year
1
Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis. ( 30543922 )
2018
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Variations for Autoimmune Atherosclerosis

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Expression for Autoimmune Atherosclerosis

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Search GEO for disease gene expression data for Autoimmune Atherosclerosis.
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Pathways for Autoimmune Atherosclerosis

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Pathways related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 37
Show member pathways
 12.07 FOXP3 HSPD1 IL10
2
Th2 Differentiation Pathway 65
10.62 FOXP3 IL10
3
Microglia Activation During Neuroinflammation: Steady-State Microglia 65
10.28 HSPD1 IL10
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GO Terms for Autoimmune Atherosclerosis

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Cellular components related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ACE APOH ENSG00000264813 HSPD1 IL10

Biological processes related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.52 FOXP3 IL10
2 response to organic substance GO:0010033 9.51 HSPD1 IL10
3 response to glucocorticoid GO:0051384 9.49 HSPD1 IL10
4 T cell activation GO:0042110 9.48 FOXP3 HSPD1
5 negative regulation of tumor necrosis factor production GO:0032720 9.46 FOXP3 IL10
6 response to activity GO:0014823 9.43 HSPD1 IL10
7 negative regulation of T cell proliferation GO:0042130 9.4 FOXP3 IL10
8 B cell proliferation GO:0042100 9.37 HSPD1 IL10
9 negative regulation of interferon-gamma production GO:0032689 9.32 FOXP3 IL10
10 negative regulation of interleukin-6 production GO:0032715 9.26 FOXP3 IL10
11 positive regulation of blood pressure GO:0045777 9.16 ACE ENSG00000264813
12 positive regulation of macrophage activation GO:0043032 8.96 HSPD1 IL10
13 positive regulation of systemic arterial blood pressure GO:0003084 8.62 ACE ENSG00000264813

Molecular functions related to Autoimmune Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxypeptidase activity GO:0004180 9.26 ACE ENSG00000264813
2 dipeptidyl-peptidase activity GO:0008239 9.16 ACE ENSG00000264813
3 exopeptidase activity GO:0008238 8.96 ACE ENSG00000264813
4 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813
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Sources for Autoimmune Atherosclerosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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