MCID: ATM060
MIFTS: 25

Autoimmune Atrophic Gastritis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Autoimmune Atrophic Gastritis

MalaCards integrated aliases for Autoimmune Atrophic Gastritis:

Name: Autoimmune Atrophic Gastritis 54

Classifications:



Summaries for Autoimmune Atrophic Gastritis

NIH Rare Diseases : 54 Autoimmune atrophic gastritis is a chronic inflammatory disease in which the immune system mistakenly destroys a special type of cell (parietal cells) in the stomach. Parietal cells make stomach acid (gastric acid) and a substance our body needs to help absorb vitamin B12 (called intrinsic factor). The progressive loss of parietal cells may lead to iron deficiency and finally vitamin B12 deficiency. The clinical signs and symptoms of iron deficiency anemia include tiredness, pale complexion, and heart problems such as exercise intolerance and palpitations. B12 deficiency may lead to pernicious anemia as well as gastrointestinal and neurological problems. Autoimmune atrophic gastritis may also be associated with an increased risk of certain types of stomach cancers.  The cause of autoimmune gastritis is unknown, but affected people are likely to have other autoimmune disorders including autoimmune thyroiditis, diabetes type I, Addison�??s disease, and vitiligo. Diagnosis is made through a combination of clinical findings (certain blood tests and presence of other autoimmune conditions) and biopsy of stomach lining. Treatment is based on the signs and symptoms present in each person, but may include iron infusions, vitamin B12 injections and endoscopic surveillance.

MalaCards based summary : Autoimmune Atrophic Gastritis is related to atrophic gastritis and gastritis. An important gene associated with Autoimmune Atrophic Gastritis is CHGA (Chromogranin A). The drugs Hydroxocobalamin and Iron have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid.

Related Diseases for Autoimmune Atrophic Gastritis

Diseases in the Atrophic Gastritis family:

Autoimmune Atrophic Gastritis

Diseases related to Autoimmune Atrophic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 atrophic gastritis 31.2 CHGA GAST
2 gastritis 31.2 CHGA GAST
3 gastric neuroendocrine neoplasm 30.0 CHGA GAST
4 duodenal gastrinoma 30.0 CHGA GAST
5 gastrinoma 30.0 CHGA GAST
6 zollinger-ellison syndrome 30.0 CHGA GAST
7 primary hyperparathyroidism 29.9 CHGA GAST
8 hyperparathyroidism 29.9 CHGA GAST
9 neuroendocrine tumor 29.7 CHGA GAST
10 iron metabolism disease 10.3
11 autoimmune disease 10.2
12 gastric cancer 10.2
13 distal trisomy 3p 10.2
14 autoimmune disease 1 10.0
15 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
16 deficiency anemia 10.0
17 microinvasive gastric cancer 10.0
18 iron deficiency anemia 10.0
19 duodenal ulcer 10.0
20 infertility 10.0
21 rosai-dorfman disease 10.0
22 gastrointestinal neuroendocrine benign tumor 10.0 CHGA GAST
23 goblet cell carcinoid 10.0 CHGA GAST
24 insulinomatosis and diabetes mellitus 10.0 CHGA GAST
25 vipoma 10.0 CHGA GAST
26 non-functioning pancreatic endocrine tumor 10.0 CHGA GAST
27 mixed ductal-endocrine carcinoma 9.9 CHGA GAST
28 islet cell tumor 9.9 CHGA GAST
29 gastrointestinal system benign neoplasm 9.9 CHGA GAST
30 serotonin syndrome 9.9 CHGA GAST
31 multiple endocrine neoplasia, type i 9.9 CHGA GAST
32 endocrine gland cancer 9.9 CHGA GAST
33 thyroid carcinoma, familial medullary 9.8 CHGA GAST
34 small cell cancer of the lung 9.7 CHGA GAST
35 gastric adenocarcinoma 9.6 CHGA GAST

Graphical network of the top 20 diseases related to Autoimmune Atrophic Gastritis:



Diseases related to Autoimmune Atrophic Gastritis

Symptoms & Phenotypes for Autoimmune Atrophic Gastritis

Drugs & Therapeutics for Autoimmune Atrophic Gastritis

Drugs for Autoimmune Atrophic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 15589840
2
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 23925 27284
3
leucovorin Approved Not Applicable 58-05-9 6006 143
4
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
5
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
6
Cobalamin Experimental Not Applicable 13408-78-1 6857388
7 Immunoglobulins Not Applicable
8 Vitamin B 12 Not Applicable
9 Hematinics Not Applicable
10 Nutrients Not Applicable
11 Vitamin B Complex Not Applicable
12 Trace Elements Not Applicable
13 Vitamins Not Applicable
14 Antibodies Not Applicable
15 Immunologic Factors Not Applicable
16 Micronutrients Not Applicable
17 Vitamin B9 Not Applicable
18 Folate Not Applicable
19 Autoantibodies Not Applicable
20 Vitamin B12 Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable

Search NIH Clinical Center for Autoimmune Atrophic Gastritis

Genetic Tests for Autoimmune Atrophic Gastritis

Anatomical Context for Autoimmune Atrophic Gastritis

MalaCards organs/tissues related to Autoimmune Atrophic Gastritis:

42
Heart, Testes, Thyroid, T Cells

Publications for Autoimmune Atrophic Gastritis

Articles related to Autoimmune Atrophic Gastritis:

(show all 33)
# Title Authors Year
1
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. ( 30531243 )
2019
2
The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective. ( 30639639 )
2019
3
Extranodal Rosai-Dorfman Disease With Mucosal Involvement of the Stomach in a Background of Autoimmune Atrophic Gastritis. ( 29720012 )
2018
4
Infertility and recurrent miscarriage in a patient with autoimmune atrophic gastritis. ( 29524079 )
2018
5
Symptomatic Non-acidic Reflux in a Patient With Chronic Autoimmune Atrophic Gastritis Successfully Treated With Anti-reflux Surgery. ( 29291616 )
2018
6
Unusual association between erythema nodosum and autoimmune atrophic gastritis. ( 29545439 )
2018
7
Mid- and Deep-Zone Gastritis: A Histologic Pattern Associated With Autoimmune Disease but Distinct From Autoimmune Atrophic Gastritis. ( 30032289 )
2018
8
Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study. ( 30409113 )
2018
9
Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis. ( 30510814 )
2018
10
Autoimmune diseases in autoimmune atrophic gastritis. ( 30561426 )
2018
11
Autoimmune atrophic gastritis: current perspectives. ( 28223833 )
2017
12
Esophageal chemical clearance and baseline impedance values in patients with chronic autoimmune atrophic gastritis and gastro-esophageal reflux disease. ( 28487082 )
2017
13
Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer. ( 28465717 )
2017
14
The challenging diagnosis of autoimmune atrophic gastritis. ( 28040990 )
2017
15
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. ( 29095917 )
2017
16
An Unusual Presentation of Pseudothrombotic Microangiopathy in a Patient with Autoimmune Atrophic Gastritis. ( 27018160 )
2016
17
Reversible normalisation of serum TSH levels in patients with autoimmune atrophic gastritis who received L-T4 in tablet form after switching to an oral liquid formulation: a case series. ( 26965518 )
2016
18
Gastro-esophageal reflux and antisecretory drugs use among patients with chronic autoimmune atrophic gastritis: a study with pH-impedance monitoring. ( 26568317 )
2015
19
Intermittent treatment of recurrent type-1 gastric carcinoids with somatostatin analogues in patients with chronic autoimmune atrophic gastritis. ( 26321479 )
2015
20
A Laboratory Score in the Diagnosis of Autoimmune Atrophic Gastritis: A Prospective Study. ( 24583750 )
2014
21
Differential proteomics of Helicobacter pylori associated with autoimmune atrophic gastritis. ( 24395566 )
2013
22
Autoimmune atrophic gastritis--pathogenesis, pathology and management. ( 23774773 )
2013
23
Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group: Analysis of 8 Clinical Cases. ( 24327126 )
2013
24
Chronic autoimmune atrophic gastritis associated with primary hyperparathyroidism: a transversal prospective study. ( 23447517 )
2013
25
Autoimmune atrophic gastritis presenting as myelopathy in a young patient. ( 22899041 )
2012
26
Common features of patients with autoimmune atrophic gastritis. ( 22387252 )
2012
27
Multifocal early gastric cancer in a patient with autoimmune atrophic gastritis and iron deficiency anaemia. ( 19197826 )
2009
28
Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis. ( 18057384 )
2007
29
Progression from iron deficiency anaemia to cobalamin depletion in autoimmune atrophic gastritis: is it simply a question of time? ( 17005459 )
2006
30
Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis. ( 16273605 )
2005
31
Prevalence of autoimmune atrophic gastritis in vitiligo. ( 3758513 )
1986
32
Autoimmune atrophic gastritis with hypergastrinemia. ( 1019670 )
1976
33
HL-A3 and HL-A7 in pernicious anaemia and autoimmune atrophic gastritis. ( 1212816 )
1975

Variations for Autoimmune Atrophic Gastritis

Expression for Autoimmune Atrophic Gastritis

Search GEO for disease gene expression data for Autoimmune Atrophic Gastritis.

Pathways for Autoimmune Atrophic Gastritis

GO Terms for Autoimmune Atrophic Gastritis

Cellular components related to Autoimmune Atrophic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.13 CHGA CTSW GAST
2 extracellular space GO:0005615 8.8 CHGA CTSW GAST

Sources for Autoimmune Atrophic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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