MCID: ATM060
MIFTS: 19

Autoimmune Atrophic Gastritis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Autoimmune Atrophic Gastritis

MalaCards integrated aliases for Autoimmune Atrophic Gastritis:

Name: Autoimmune Atrophic Gastritis 20

Classifications:



Summaries for Autoimmune Atrophic Gastritis

GARD : 20 Autoimmune atrophic gastritis is a chronic inflammatory disease in which the immune system mistakenly destroys a special type of cell (parietal cells) in the stomach. Parietal cells make stomach acid (gastric acid) and a substance our body needs to help absorb vitamin B 12 (called intrinsic factor). The progressive loss of parietal cells may lead to iron deficiency and finally vitamin B 12 deficiency. The clinical signs and symptoms of iron deficiency anemia include tiredness, pale complexion, and heart problems such as exercise intolerance and palpitations. B 12 deficiency may lead to pernicious anemia as well as gastrointestinal and neurological problems. Autoimmune atrophic gastritis may also be associated with an increased risk of certain types of stomach cancers. The cause of autoimmune gastritis is unknown, but affected people are likely to have other autoimmune disorders including autoimmune thyroiditis, diabetes type I, Addison's disease, and vitiligo. Diagnosis is made through a combination of clinical findings (certain blood tests and presence of other autoimmune conditions) and biopsy of stomach lining. Treatment is based on the signs and symptoms present in each person, but may include iron infusions, vitamin B 12 injections and endoscopic surveillance.

MalaCards based summary : Autoimmune Atrophic Gastritis is related to atrophic gastritis and gastritis. An important gene associated with Autoimmune Atrophic Gastritis is CHGA (Chromogranin A). Affiliated tissues include thyroid, spleen and t cells.

Related Diseases for Autoimmune Atrophic Gastritis

Diseases in the Atrophic Gastritis family:

Autoimmune Atrophic Gastritis

Diseases related to Autoimmune Atrophic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 atrophic gastritis 31.3 GAST CHGA
2 gastritis 31.3 GAST CHGA
3 pernicious anemia 30.4 GAST CHGA
4 gastrinoma 30.0 GAST CHGA
5 duodenal gastrinoma 30.0 GAST CHGA
6 gastric neuroendocrine neoplasm 30.0 GAST CHGA
7 neuroendocrine tumor 30.0 GAST CHGA
8 zollinger-ellison syndrome 29.9 GAST CHGA
9 hyperparathyroidism 29.8 GAST CHGA
10 primary hyperparathyroidism 29.8 GAST CHGA
11 helicobacter pylori infection 10.5
12 iron metabolism disease 10.5
13 vitamin b12 deficiency 10.4
14 autoimmune gastritis 10.4
15 autoimmune disease 10.3
16 deficiency anemia 10.3
17 celiac disease 1 10.3
18 gastric cancer 10.3
19 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
20 type 1 diabetes mellitus 10.2
21 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
22 rickets 10.2
23 iron deficiency anemia 10.2
24 duodenal ulcer 10.2
25 gastric adenocarcinoma 10.2
26 infertility 10.2
27 myasthenia gravis 10.0
28 homocysteinemia 10.0
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
30 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
31 chronic spontaneous urticaria 10.0
32 erythema nodosum 10.0
33 microinvasive gastric cancer 10.0
34 thrombotic thrombocytopenic purpura 10.0
35 pancytopenia 10.0
36 secondary hyperparathyroidism 10.0
37 urticaria 10.0
38 adenocarcinoma 10.0
39 purpura 10.0
40 histiocytosis 10.0
41 thyroiditis 10.0
42 peptic ulcer disease 10.0
43 gastrointestinal system disease 10.0
44 lichen planus 10.0
45 oral lichen planus 10.0
46 rosai-dorfman disease 10.0
47 gastric gastrinoma 10.0 GAST CHGA
48 gastrointestinal neuroendocrine benign tumor 10.0 GAST CHGA
49 mixed ductal-endocrine carcinoma 10.0 GAST CHGA
50 non-functioning pancreatic endocrine tumor 10.0 GAST CHGA

Graphical network of the top 20 diseases related to Autoimmune Atrophic Gastritis:



Diseases related to Autoimmune Atrophic Gastritis

Symptoms & Phenotypes for Autoimmune Atrophic Gastritis

Drugs & Therapeutics for Autoimmune Atrophic Gastritis

Search Clinical Trials , NIH Clinical Center for Autoimmune Atrophic Gastritis

Genetic Tests for Autoimmune Atrophic Gastritis

Anatomical Context for Autoimmune Atrophic Gastritis

MalaCards organs/tissues related to Autoimmune Atrophic Gastritis:

40
Thyroid, Spleen, T Cells, Endothelial, Colon, Lung, Pancreas

Publications for Autoimmune Atrophic Gastritis

Articles related to Autoimmune Atrophic Gastritis:

(show top 50) (show all 130)
# Title Authors PMID Year
1
Refractory iron-deficiency anemia and autoimmune atrophic gastritis in pediatric age group: analysis of 8 clinical cases. 20 61
24327126 2014
2
Autoimmune atrophic gastritis--pathogenesis, pathology and management. 61 20
23774773 2013
3
Review of autoimmune metaplastic atrophic gastritis. 20
23199649 2013
4
Objective Evidence of Gastro-Esophageal Reflux Disease is Rare in Patients with Autoimmune Gastritis. 61
33723550 2021
5
Development of white globe appearance lesions in the noncancerous stomach after vonoprazan administration: a report of two cases with a literature review. 61
33025345 2021
6
Proteomics signature of autoimmune atrophic gastritis: towards a link with gastric cancer. 61
33620602 2021
7
Gastrointestinal involvement of primary skin diseases. 61
32455473 2020
8
Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome. 61
32883568 2020
9
Serum pepsinogen levels and OLGA/OLGIM staging in the assessment of atrophic gastritis types. 61
33380437 2020
10
Seronegative autoimmune atrophic gastritis is more common in elderly patients. 61
32487505 2020
11
Low prevalence of upper endoscopic gastrointestinal findings despite high frequency of alarm symptoms at the time of diagnosis in adult coeliac disease. 61
32675775 2020
12
Autoimmune diseases associated with common variable immune deficiency. 61
33236426 2020
13
Autoimmune Gastritis and Gastric Microbiota. 61
33228138 2020
14
Relationship between atrophic gastritis, serum ghrelin and body mass index. 61
32773508 2020
15
Autoimmune atrophic gastritis: The role of Helicobacter pylori infection in children. 61
32589356 2020
16
Duodenal Histological Findings and Risk of Coeliac Disease in Subjects with Autoimmune Atrophic Gastritis: A Retrospective Evaluation. 61
33075781 2020
17
Impaired Quality of Life in Patients with Autoimmune Atrophic Gastritis. 61
33098024 2020
18
Helicobacter pylori-induced inflammation masks the underlying presence of low-grade dysplasia on gastric lesions. 61
32774061 2020
19
Defective spleen function in autoimmune gastrointestinal disorders. 61
31214883 2020
20
Role of Pernicious Anemia in Patients Admitted to Internal Medicine with Vitamin B12 Deficiency and Oral Replacement Therapy as a Treatment Option. 61
32162860 2020
21
High frequency of anti-parietal cell antibody (APCA) and intrinsic factor blocking antibody (IFBA) in individuals with severe vitamin B12 deficiency - an observational study in primary care patients. 61
31714882 2020
22
Thyro-entero-gastric autoimmunity: Pathophysiology and implications for patient management. 61
31864909 2020
23
Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors. 61
32004755 2020
24
Natural history of autoimmune atrophic gastritis: a prospective, single centre, long-term experience. 61
31621927 2019
25
Pathologic findings of the removed stomach during sleeve gastrectomy. 61
30771070 2019
26
Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study. 61
31731715 2019
27
Editorial: determinants of diagnostic delay in autoimmune atrophic gastritis-a salutary lesson. Authors' reply. 61
31359467 2019
28
Editorial: determinants of diagnostic delay in autoimmune atrophic gastritis-a salutary lesson. 61
31359482 2019
29
Determinants of diagnostic delay in autoimmune atrophic gastritis. 61
31115910 2019
30
Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. 61
30736997 2019
31
Polymorphism in Toll-Like Receptors and Helicobacter Pylori Motility in Autoimmune Atrophic Gastritis and Gastric Cancer. 61
31083432 2019
32
The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective. 61
30639639 2019
33
Factors related to gastric neuroendocrine tumors. 61
29705524 2019
34
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. 61
30531243 2019
35
Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS). 61
30539573 2019
36
Autoimmune polyendocrine syndrome type 2 in patient with severe allergic asthma treated with omalizumab. 61
29300536 2018
37
Autoimmune diseases in autoimmune atrophic gastritis. 61
30561426 2018
38
Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study. 61
30409113 2018
39
The differential diagnosis of Helicobacter pylori negative gastritis. 61
30255340 2018
40
Extranodal Rosai-Dorfman Disease With Mucosal Involvement of the Stomach in a Background of Autoimmune Atrophic Gastritis. 61
29720012 2018
41
Pernicious Anemia Presented with Isolated Nominal Dysphasia in Type Ill Polyglandular Failure Female Patient. 61
30519517 2018
42
Mid- and Deep-Zone Gastritis: A Histologic Pattern Associated With Autoimmune Disease but Distinct From Autoimmune Atrophic Gastritis. 61
30032289 2018
43
Infertility and recurrent miscarriage in a patient with autoimmune atrophic gastritis. 61
29524079 2018
44
Unusual association between erythema nodosum and autoimmune atrophic gastritis. 61
29545439 2018
45
Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis. 61
30510814 2018
46
Symptomatic Non-acidic Reflux in a Patient With Chronic Autoimmune Atrophic Gastritis Successfully Treated With Anti-reflux Surgery. 61
29291616 2018
47
Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis. 61
29930985 2018
48
Gastroduodenal Disorders in Patients with CVID Undergoing Immunoglobulin Therapy. 61
30336770 2018
49
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. 61
29095917 2017
50
Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases. 61
28733178 2017

Variations for Autoimmune Atrophic Gastritis

Expression for Autoimmune Atrophic Gastritis

Search GEO for disease gene expression data for Autoimmune Atrophic Gastritis.

Pathways for Autoimmune Atrophic Gastritis

GO Terms for Autoimmune Atrophic Gastritis

Cellular components related to Autoimmune Atrophic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.13 GAST CTSW CHGA
2 extracellular space GO:0005615 8.8 GAST CTSW CHGA

Sources for Autoimmune Atrophic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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