MCID: ATM060
MIFTS: 20

Autoimmune Atrophic Gastritis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Autoimmune Atrophic Gastritis

MalaCards integrated aliases for Autoimmune Atrophic Gastritis:

Name: Autoimmune Atrophic Gastritis 53

Classifications:



Summaries for Autoimmune Atrophic Gastritis

NIH Rare Diseases : 53 Autoimmune atrophic gastritis is a chronic inflammatory disease in which the immune system mistakenly destroys a special type of cell (parietal cells) in the stomach. Parietal cells make stomach acid (gastric acid) and a substance our body needs to help absorb vitamin B12 (called intrinsic factor). The progressive loss of parietal cells may lead to iron deficiency and finally vitamin B12 deficiency. The clinical signs and symptoms of iron deficiency anemia include tiredness, pale complexion, and heart problems such as exercise intolerance and palpitations. B12 deficiency may lead to pernicious anemia as well as gastrointestinal and neurological problems. Autoimmune atrophic gastritis may also be associated with an increased risk of certain types of stomach cancers.  The cause of autoimmune gastritis is unknown, but affected people are likely to have other autoimmune disorders including autoimmune thyroiditis, diabetes type I, Addison�??s disease, and vitiligo. Diagnosis is made through a combination of clinical findings (certain blood tests and presence of other autoimmune conditions) and biopsy of stomach lining. Treatment is based on the signs and symptoms present in each person, but may include iron infusions, vitamin B12 injections and endoscopic surveillance.

MalaCards based summary : Autoimmune Atrophic Gastritis is related to atrophic gastritis and gastritis. An important gene associated with Autoimmune Atrophic Gastritis is CHGA (Chromogranin A). The drugs Hydroxocobalamin and Iron have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid.

Related Diseases for Autoimmune Atrophic Gastritis

Diseases in the Atrophic Gastritis family:

Autoimmune Atrophic Gastritis

Diseases related to Autoimmune Atrophic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 atrophic gastritis 31.2 CHGA GAST
2 gastritis 31.2 CHGA GAST
3 gastric neuroendocrine neoplasm 30.0 CHGA GAST
4 duodenal gastrinoma 30.0 CHGA GAST
5 gastrinoma 30.0 CHGA GAST
6 zollinger-ellison syndrome 30.0 CHGA GAST
7 primary hyperparathyroidism 29.9 CHGA GAST
8 hyperparathyroidism 29.9 CHGA GAST
9 neuroendocrine tumor 29.8 CHGA GAST
10 iron metabolism disease 10.3
11 gastric cancer 10.2
12 autoimmune disease 10.0
13 deficiency anemia 10.0
14 microinvasive gastric cancer 10.0
15 iron deficiency anemia 10.0
16 duodenal ulcer 10.0
17 infertility 10.0
18 rosai-dorfman disease 10.0
19 gastrointestinal neuroendocrine benign tumor 10.0 CHGA GAST
20 goblet cell carcinoid 10.0 CHGA GAST
21 insulinomatosis and diabetes mellitus 10.0 CHGA GAST
22 vipoma 10.0 CHGA GAST
23 non-functioning pancreatic endocrine tumor 10.0 CHGA GAST
24 mixed ductal-endocrine carcinoma 10.0 CHGA GAST
25 islet cell tumor 10.0 CHGA GAST
26 gastrointestinal system benign neoplasm 10.0 CHGA GAST
27 serotonin syndrome 9.9 CHGA GAST
28 multiple endocrine neoplasia, type i 9.9 CHGA GAST
29 endocrine gland cancer 9.9 CHGA GAST
30 thyroid carcinoma, familial medullary 9.9 CHGA GAST
31 small cell cancer of the lung 9.8 CHGA GAST
32 gastric adenocarcinoma 9.8 CHGA GAST

Graphical network of the top 20 diseases related to Autoimmune Atrophic Gastritis:



Diseases related to Autoimmune Atrophic Gastritis

Symptoms & Phenotypes for Autoimmune Atrophic Gastritis

Drugs & Therapeutics for Autoimmune Atrophic Gastritis

Drugs for Autoimmune Atrophic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
2
Iron Approved Not Applicable 7439-89-6 23925
3
leucovorin Approved Not Applicable 58-05-9 6006 143
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
6
Cobalamin Experimental Not Applicable 13408-78-1 6438156
7 Trace Elements Not Applicable
8 Immunologic Factors Not Applicable
9 Vitamin B 12 Not Applicable
10 Vitamin B9 Not Applicable
11 Autoantibodies Not Applicable
12 Vitamin B Complex Not Applicable
13 Micronutrients Not Applicable
14 Hematinics Not Applicable
15 Vitamins Not Applicable
16 Folate Not Applicable
17 Immunoglobulins Not Applicable
18 Vitamin B12 Not Applicable
19 Antibodies Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable

Search NIH Clinical Center for Autoimmune Atrophic Gastritis

Genetic Tests for Autoimmune Atrophic Gastritis

Anatomical Context for Autoimmune Atrophic Gastritis

MalaCards organs/tissues related to Autoimmune Atrophic Gastritis:

41
Heart, Testes, Thyroid, T Cells, Lung

Publications for Autoimmune Atrophic Gastritis

Articles related to Autoimmune Atrophic Gastritis:

(show all 31)
# Title Authors Year
1
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. ( 30531243 )
2019
2
Extranodal Rosai-Dorfman Disease With Mucosal Involvement of the Stomach in a Background of Autoimmune Atrophic Gastritis. ( 29720012 )
2018
3
Infertility and recurrent miscarriage in a patient with autoimmune atrophic gastritis. ( 29524079 )
2018
4
Symptomatic Non-acidic Reflux in a Patient With Chronic Autoimmune Atrophic Gastritis Successfully Treated With Anti-reflux Surgery. ( 29291616 )
2018
5
Unusual association between erythema nodosum and autoimmune atrophic gastritis. ( 29545439 )
2018
6
Mid- and Deep-Zone Gastritis: A Histologic Pattern Associated With Autoimmune Disease but Distinct From Autoimmune Atrophic Gastritis. ( 30032289 )
2018
7
Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study. ( 30409113 )
2018
8
Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis. ( 30510814 )
2018
9
Autoimmune atrophic gastritis: current perspectives. ( 28223833 )
2017
10
Esophageal chemical clearance and baseline impedance values in patients with chronic autoimmune atrophic gastritis and gastro-esophageal reflux disease. ( 28487082 )
2017
11
Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer. ( 28465717 )
2017
12
The challenging diagnosis of autoimmune atrophic gastritis. ( 28040990 )
2017
13
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. ( 29095917 )
2017
14
An Unusual Presentation of Pseudothrombotic Microangiopathy in a Patient with Autoimmune Atrophic Gastritis. ( 27018160 )
2016
15
Reversible normalisation of serum TSH levels in patients with autoimmune atrophic gastritis who received L-T4 in tablet form after switching to an oral liquid formulation: a case series. ( 26965518 )
2016
16
Gastro-esophageal reflux and antisecretory drugs use among patients with chronic autoimmune atrophic gastritis: a study with pH-impedance monitoring. ( 26568317 )
2015
17
Intermittent treatment of recurrent type-1 gastric carcinoids with somatostatin analogues in patients with chronic autoimmune atrophic gastritis. ( 26321479 )
2015
18
A Laboratory Score in the Diagnosis of Autoimmune Atrophic Gastritis: A Prospective Study. ( 24583750 )
2014
19
Differential proteomics of Helicobacter pylori associated with autoimmune atrophic gastritis. ( 24395566 )
2013
20
Autoimmune atrophic gastritis--pathogenesis, pathology and management. ( 23774773 )
2013
21
Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group: Analysis of 8 Clinical Cases. ( 24327126 )
2013
22
Chronic autoimmune atrophic gastritis associated with primary hyperparathyroidism: a transversal prospective study. ( 23447517 )
2013
23
Autoimmune atrophic gastritis presenting as myelopathy in a young patient. ( 22899041 )
2012
24
Common features of patients with autoimmune atrophic gastritis. ( 22387252 )
2012
25
Multifocal early gastric cancer in a patient with autoimmune atrophic gastritis and iron deficiency anaemia. ( 19197826 )
2009
26
Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis. ( 18057384 )
2007
27
Progression from iron deficiency anaemia to cobalamin depletion in autoimmune atrophic gastritis: is it simply a question of time? ( 17005459 )
2006
28
Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis. ( 16273605 )
2005
29
Prevalence of autoimmune atrophic gastritis in vitiligo. ( 3758513 )
1986
30
Autoimmune atrophic gastritis with hypergastrinemia. ( 1019670 )
1976
31
HL-A3 and HL-A7 in pernicious anaemia and autoimmune atrophic gastritis. ( 1212816 )
1975

Variations for Autoimmune Atrophic Gastritis

Expression for Autoimmune Atrophic Gastritis

Search GEO for disease gene expression data for Autoimmune Atrophic Gastritis.

Pathways for Autoimmune Atrophic Gastritis

GO Terms for Autoimmune Atrophic Gastritis

Cellular components related to Autoimmune Atrophic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.13 CHGA CTSW GAST
2 extracellular space GO:0005615 8.8 CHGA CTSW GAST

Sources for Autoimmune Atrophic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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