MCID: ATM060
MIFTS: 24

Autoimmune Atrophic Gastritis

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Autoimmune Atrophic Gastritis

MalaCards integrated aliases for Autoimmune Atrophic Gastritis:

Name: Autoimmune Atrophic Gastritis 53

Classifications:



Summaries for Autoimmune Atrophic Gastritis

NIH Rare Diseases : 53 Autoimmune atrophic gastritis is a chronic inflammatory disease in which the immune system mistakenly destroys a special type of cell (parietal cells) in the stomach. Parietal cells make stomach acid (gastric acid) and a substance our body needs to help absorb vitamin B12 (called intrinsic factor). The progressive loss of parietal cells may lead to iron deficiency and finally vitamin B12 deficiency. The clinical signs and symptoms of iron deficiency anemia include tiredness, pale complexion, and heart problems such as exercise intolerance and palpitations. B12 deficiency may lead to pernicious anemia as well as gastrointestinal and neurological problems. Autoimmune atrophic gastritis may also be associated with an increased risk of certain types of stomach cancers.  The cause of autoimmune gastritis is unknown, but affected people are likely to have other autoimmune disorders including autoimmune thyroiditis, diabetes type I, Addison’s disease, and vitiligo. Diagnosis is made through a combination of clinical findings (certain blood tests and presence of other autoimmune conditions) and biopsy of stomach lining. Treatment is based on the signs and symptoms present in each person, but may include iron infusions, vitamin B12 injections and endoscopic surveillance.

MalaCards based summary : Autoimmune Atrophic Gastritis is related to atrophic gastritis and gastritis. An important gene associated with Autoimmune Atrophic Gastritis is CHGA (Chromogranin A). The drugs Iron and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include testes, thyroid and heart.

Related Diseases for Autoimmune Atrophic Gastritis

Graphical network of the top 20 diseases related to Autoimmune Atrophic Gastritis:



Diseases related to Autoimmune Atrophic Gastritis

Symptoms & Phenotypes for Autoimmune Atrophic Gastritis

Drugs & Therapeutics for Autoimmune Atrophic Gastritis

Drugs for Autoimmune Atrophic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Not Applicable 7439-89-6 23925
2
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
3
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
6 Micronutrients Not Applicable
7 Hematinics Not Applicable
8 Trace Elements Not Applicable
9 Vitamin B 12 Not Applicable
10 Vitamin B Complex Not Applicable
11 Vitamins Not Applicable
12 Antibodies Not Applicable
13 Immunoglobulins Not Applicable
14 Autoantibodies Not Applicable
15 Vitamin B12 Nutraceutical Not Applicable
16 Folate Nutraceutical Not Applicable
17
Cobalamin Nutraceutical Not Applicable 13408-78-1 6438156
18 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable

Search NIH Clinical Center for Autoimmune Atrophic Gastritis

Genetic Tests for Autoimmune Atrophic Gastritis

Anatomical Context for Autoimmune Atrophic Gastritis

MalaCards organs/tissues related to Autoimmune Atrophic Gastritis:

41
Testes, Thyroid, Heart, T Cells

Publications for Autoimmune Atrophic Gastritis

Articles related to Autoimmune Atrophic Gastritis:

(show all 27)
# Title Authors Year
1
Extranodal Rosai-Dorfman Disease With Mucosal Involvement of the Stomach in a Background of Autoimmune Atrophic Gastritis. ( 29720012 )
2018
2
Infertility and recurrent miscarriage in a patient with autoimmune atrophic gastritis. ( 29524079 )
2018
3
Symptomatic Non-acidic Reflux in a Patient With Chronic Autoimmune Atrophic Gastritis Successfully Treated With Anti-reflux Surgery. ( 29291616 )
2018
4
Unusual association between erythema nodosum and autoimmune atrophic gastritis. ( 29545439 )
2018
5
Autoimmune atrophic gastritis: current perspectives. ( 28223833 )
2017
6
Esophageal chemical clearance and baseline impedance values in patients with chronic autoimmune atrophic gastritis and gastro-esophageal reflux disease. ( 28487082 )
2017
7
Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer. ( 28465717 )
2017
8
The challenging diagnosis of autoimmune atrophic gastritis. ( 28040990 )
2017
9
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. ( 29095917 )
2017
10
An Unusual Presentation of Pseudothrombotic Microangiopathy in a Patient with Autoimmune Atrophic Gastritis. ( 27018160 )
2016
11
Reversible normalisation of serum TSH levels in patients with autoimmune atrophic gastritis who received L-T4 in tablet form after switching to an oral liquid formulation: a case series. ( 26965518 )
2016
12
Gastro-esophageal reflux and antisecretory drugs use among patients with chronic autoimmune atrophic gastritis: a study with pH-impedance monitoring. ( 26568317 )
2015
13
Intermittent treatment of recurrent type-1 gastric carcinoids with somatostatin analogues in patients with chronic autoimmune atrophic gastritis. ( 26321479 )
2015
14
A Laboratory Score in the Diagnosis of Autoimmune Atrophic Gastritis: A Prospective Study. ( 24583750 )
2014
15
Differential proteomics of Helicobacter pylori associated with autoimmune atrophic gastritis. ( 24395566 )
2013
16
Autoimmune atrophic gastritis--pathogenesis, pathology and management. ( 23774773 )
2013
17
Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group: Analysis of 8 Clinical Cases. ( 24327126 )
2013
18
Chronic autoimmune atrophic gastritis associated with primary hyperparathyroidism: a transversal prospective study. ( 23447517 )
2013
19
Autoimmune atrophic gastritis presenting as myelopathy in a young patient. ( 22899041 )
2012
20
Common features of patients with autoimmune atrophic gastritis. ( 22387252 )
2012
21
Multifocal early gastric cancer in a patient with autoimmune atrophic gastritis and iron deficiency anaemia. ( 19197826 )
2009
22
Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis. ( 18057384 )
2007
23
Progression from iron deficiency anaemia to cobalamin depletion in autoimmune atrophic gastritis: is it simply a question of time? ( 17005459 )
2006
24
Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis. ( 16273605 )
2005
25
Prevalence of autoimmune atrophic gastritis in vitiligo. ( 3758513 )
1986
26
Autoimmune atrophic gastritis with hypergastrinemia. ( 1019670 )
1976
27
HL-A3 and HL-A7 in pernicious anaemia and autoimmune atrophic gastritis. ( 1212816 )
1975

Variations for Autoimmune Atrophic Gastritis

Expression for Autoimmune Atrophic Gastritis

Search GEO for disease gene expression data for Autoimmune Atrophic Gastritis.

Pathways for Autoimmune Atrophic Gastritis

GO Terms for Autoimmune Atrophic Gastritis

Cellular components related to Autoimmune Atrophic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.13 CHGA CTSW GAST
2 extracellular space GO:0005615 8.8 CHGA CTSW GAST

Sources for Autoimmune Atrophic Gastritis

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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
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71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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