MCID: ATM102
MIFTS: 29

Autoimmune Cardiomyopathy

Categories: Blood diseases, Cardiovascular diseases, Ear diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Cardiomyopathy

MalaCards integrated aliases for Autoimmune Cardiomyopathy:

Name: Autoimmune Cardiomyopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040095

Summaries for Autoimmune Cardiomyopathy

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by deterioration of the function of the heart muscle.

MalaCards based summary : Autoimmune Cardiomyopathy is related to atrial standstill 1 and severe combined immunodeficiency. An important gene associated with Autoimmune Cardiomyopathy is LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Translocation of ZAP-70 to Immunological synapse. Affiliated tissues include heart and t cells, and related phenotype is endocrine/exocrine gland.

Related Diseases for Autoimmune Cardiomyopathy

Diseases in the Dilated Cardiomyopathy family:

Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 3b
Cardiomyopathy, Dilated, 1b Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1i
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1o Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated, 1w
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 2a Cardiomyopathy, Dilated, 1bb
Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1ff
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1kk Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 2c Autoimmune Cardiomyopathy
Dilated Cardiomyopathy 1t Lmna-Related Dilated Cardiomyopathy
Cardiomyopathy Due to Anthracyclines

Diseases related to Autoimmune Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 atrial standstill 1 9.9
2 severe combined immunodeficiency 9.9
3 combined t cell and b cell immunodeficiency 9.9
4 low compliance bladder 9.8 ADRB3 CHRM2
5 antiphospholipid syndrome 9.7
6 distal trisomy 9q 9.7
7 cd45 deficiency 9.6 LCK ZAP70
8 autoimmune disease of cardiovascular system 9.5 ADRB1 LCK SYCP3

Graphical network of the top 20 diseases related to Autoimmune Cardiomyopathy:



Diseases related to Autoimmune Cardiomyopathy

Symptoms & Phenotypes for Autoimmune Cardiomyopathy

MGI Mouse Phenotypes related to Autoimmune Cardiomyopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 ADRB1 ADRB3 LCK SYCP3 ZAP70

Drugs & Therapeutics for Autoimmune Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Cardiomyopathy

Genetic Tests for Autoimmune Cardiomyopathy

Anatomical Context for Autoimmune Cardiomyopathy

MalaCards organs/tissues related to Autoimmune Cardiomyopathy:

42
Heart, T Cells

Publications for Autoimmune Cardiomyopathy

Articles related to Autoimmune Cardiomyopathy:

(show all 13)
# Title Authors Year
1
Life-threatening Autoimmune Cardiomyopathy Reproducibly Induced in a Patient by Checkpoint Inhibitor Therapy. ( 29077601 )
2018
2
Interleukin-6-deficient mice resist development of experimental autoimmune cardiomyopathy induced by immunization of β1-adrenergic receptor. ( 21334079 )
2012
3
Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. ( 18586265 )
2008
4
Analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in anti-CD4 monoclonal antibody treated mice with autoimmune cardiomyopathy. ( 18704301 )
2008
5
Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. ( 17545481 )
2007
6
A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse autoimmune cardiomyopathy. ( 17711737 )
2007
7
Transfer of immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) mice induces cardiomyopathic changes. ( 16698668 )
2006
8
Analysis of IgG subclass antibodies and expression of T-Cell receptor signaling molecules in anti-CD4 monoclonal antibody treated mice with autoimmune cardiomyopathy. ( 17060024 )
2006
9
Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function. ( 16780870 )
2006
10
Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency mice. ( 14871038 )
2003
11
Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice. ( 14570980 )
2003
12
Acute autoimmune cardiomyopathy in primary antiphospholipid antibody syndrome. ( 12002935 )
2002
13
Prevention of experimental autoimmune cardiomyopathy in rabbits by receptor blockers. ( 11908781 )
2001

Variations for Autoimmune Cardiomyopathy

Expression for Autoimmune Cardiomyopathy

Search GEO for disease gene expression data for Autoimmune Cardiomyopathy.

Pathways for Autoimmune Cardiomyopathy

Pathways related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 ADRB1 ADRB3 CHRM2
2
Show member pathways
11.61 LCK ZAP70
3
Show member pathways
11.6 LCK ZAP70
4 11.54 LCK ZAP70
5 11.42 LCK ZAP70
6 11.41 ADRB1 ADRB3 CHRM2
7 11.39 LCK ZAP70
8 11.38 LCK ZAP70
9 11.35 ADRB1 ADRB3
10 11.24 ADRB1 CHRM2
11 11.22 LCK ZAP70
12 11.2 ADRB1 ADRB3
13 11 ADRB1 LCK
14 10.89 LCK ZAP70
15
Show member pathways
10.84 ADRB1 ADRB3 CHRM2
16 10.78 LCK ZAP70
17 10.65 LCK ZAP70
18 9.88 ADRB1 LCK

GO Terms for Autoimmune Cardiomyopathy

Cellular components related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immunological synapse GO:0001772 8.62 LCK ZAP70

Biological processes related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.46 LCK ZAP70
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.43 ADRB1 ADRB3
3 positive regulation of cold-induced thermogenesis GO:0120162 9.4 ADRB1 ADRB3
4 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.37 ADRB3 CHRM2
5 T cell differentiation GO:0030217 9.32 LCK ZAP70
6 activation of adenylate cyclase activity GO:0007190 9.26 ADRB1 ADRB3
7 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.16 ADRB1 ADRB3
8 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.13 ADRB1 ADRB3 CHRM2
9 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 8.62 ADRB1 ADRB3

Molecular functions related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.37 LCK ZAP70
2 phosphotyrosine residue binding GO:0001784 9.32 LCK ZAP70
3 adrenergic receptor activity GO:0004935 9.26 ADRB1 ADRB3
4 epinephrine binding GO:0051379 9.16 ADRB1 ADRB3
5 norepinephrine binding GO:0051380 8.96 ADRB1 ADRB3
6 beta-adrenergic receptor activity GO:0004939 8.62 ADRB1 ADRB3

Sources for Autoimmune Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....