MCID: ATM102
MIFTS: 29

Autoimmune Cardiomyopathy

Categories: Blood diseases, Cardiovascular diseases, Ear diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Cardiomyopathy

MalaCards integrated aliases for Autoimmune Cardiomyopathy:

Name: Autoimmune Cardiomyopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040095

Summaries for Autoimmune Cardiomyopathy

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by deterioration of the function of the heart muscle.

MalaCards based summary : Autoimmune Cardiomyopathy is related to severe combined immunodeficiency and combined t cell and b cell immunodeficiency. An important gene associated with Autoimmune Cardiomyopathy is LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase), and among its related pathways/superpathways are Immune response Function of MEF2 in T lymphocytes and Tyrosine Kinases / Adaptors. Affiliated tissues include heart, t cells and b cells, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Autoimmune Cardiomyopathy

Diseases in the Dilated Cardiomyopathy family:

Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 3b
Cardiomyopathy, Dilated, 1b Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1i
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1o Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated, 1w
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 2a Cardiomyopathy, Dilated, 1bb
Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1ff
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1kk Cardiomyopathy, Dilated, 1nn
Autoimmune Cardiomyopathy Dilated Cardiomyopathy 1t
Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines

Diseases related to Autoimmune Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 severe combined immunodeficiency 9.9
2 combined t cell and b cell immunodeficiency 9.9
3 cd45 deficiency 9.8 LCK ZAP70
4 atrial standstill 1 9.7
5 antiphospholipid syndrome 9.7
6 autoimmune disease of cardiovascular system 9.5 ADRB1 LCK SYCP3

Graphical network of the top 20 diseases related to Autoimmune Cardiomyopathy:



Diseases related to Autoimmune Cardiomyopathy

Symptoms & Phenotypes for Autoimmune Cardiomyopathy

GenomeRNAi Phenotypes related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.44 ZAP70
2 Decreased viability GR00221-A-1 9.44 LCK ZAP70
3 Decreased viability GR00221-A-2 9.44 LCK ZAP70
4 Decreased viability GR00221-A-3 9.44 LCK
5 Decreased viability GR00301-A 9.44 LCK
6 Decreased viability GR00342-S-1 9.44 LCK ZAP70
7 Decreased viability GR00342-S-2 9.44 ZAP70
8 Decreased viability GR00342-S-3 9.44 LCK
9 Decreased viability GR00402-S-2 9.44 LCK ZAP70

MGI Mouse Phenotypes related to Autoimmune Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.92 ADRB1 LCK SYCP3 ZAP70

Drugs & Therapeutics for Autoimmune Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Cardiomyopathy

Genetic Tests for Autoimmune Cardiomyopathy

Anatomical Context for Autoimmune Cardiomyopathy

MalaCards organs/tissues related to Autoimmune Cardiomyopathy:

41
Heart, T Cells, B Cells

Publications for Autoimmune Cardiomyopathy

Articles related to Autoimmune Cardiomyopathy:

(show all 13)
# Title Authors Year
1
Life-threatening Autoimmune Cardiomyopathy Reproducibly Induced in a Patient by Checkpoint Inhibitor Therapy. ( 29077601 )
2018
2
Interleukin-6-deficient mice resist development of experimental autoimmune cardiomyopathy induced by immunization of β1-adrenergic receptor. ( 21334079 )
2012
3
Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. ( 18586265 )
2008
4
Analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in anti-CD4 monoclonal antibody treated mice with autoimmune cardiomyopathy. ( 18704301 )
2008
5
Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. ( 17545481 )
2007
6
A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse autoimmune cardiomyopathy. ( 17711737 )
2007
7
Transfer of immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) mice induces cardiomyopathic changes. ( 16698668 )
2006
8
Analysis of IgG subclass antibodies and expression of T-Cell receptor signaling molecules in anti-CD4 monoclonal antibody treated mice with autoimmune cardiomyopathy. ( 17060024 )
2006
9
Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function. ( 16780870 )
2006
10
Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency mice. ( 14871038 )
2003
11
Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice. ( 14570980 )
2003
12
Acute autoimmune cardiomyopathy in primary antiphospholipid antibody syndrome. ( 12002935 )
2002
13
Prevention of experimental autoimmune cardiomyopathy in rabbits by receptor blockers. ( 11908781 )
2001

Variations for Autoimmune Cardiomyopathy

Expression for Autoimmune Cardiomyopathy

Search GEO for disease gene expression data for Autoimmune Cardiomyopathy.

Pathways for Autoimmune Cardiomyopathy

Pathways related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.72 LCK ZAP70
2 11.72 LCK ZAP70
3
Show member pathways
11.6 ADRB1 CHRM2
4
Show member pathways
11.56 LCK ZAP70
5 11.54 LCK ZAP70
6
Show member pathways
11.54 LCK ZAP70
7 11.47 LCK ZAP70
8 11.35 LCK ZAP70
9 11.31 LCK ZAP70
10 11.29 LCK ZAP70
11 11.18 LCK ZAP70
12 11.15 ADRB1 CHRM2
13 11.11 LCK ZAP70
14 10.89 ADRB1 LCK
15 10.72 LCK ZAP70
16 10.47 LCK ZAP70
17 10.11 LCK ZAP70
18 9.73 ADRB1 LCK

GO Terms for Autoimmune Cardiomyopathy

Cellular components related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immunological synapse GO:0001772 8.62 LCK ZAP70

Biological processes related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.26 LCK ZAP70
2 T cell receptor signaling pathway GO:0050852 9.16 LCK ZAP70
3 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 8.96 ADRB1 CHRM2
4 T cell differentiation GO:0030217 8.62 LCK ZAP70

Molecular functions related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.16 LCK ZAP70
2 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.96 LCK ZAP70
3 phosphotyrosine residue binding GO:0001784 8.62 LCK ZAP70

Sources for Autoimmune Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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