MCID: ATM102
MIFTS: 27

Autoimmune Cardiomyopathy

Categories: Bone diseases, Cardiovascular diseases, Ear diseases, Genetic diseases, Immune diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Cardiomyopathy

MalaCards integrated aliases for Autoimmune Cardiomyopathy:

Name: Autoimmune Cardiomyopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040095

Summaries for Autoimmune Cardiomyopathy

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by deterioration of the function of the heart muscle.

MalaCards based summary : Autoimmune Cardiomyopathy is related to combined immunodeficiency and immune deficiency disease. An important gene associated with Autoimmune Cardiomyopathy is LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotype is endocrine/exocrine gland.

Related Diseases for Autoimmune Cardiomyopathy

Diseases in the Rare Cardiomyopathy family:

Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 3b
Cardiomyopathy, Dilated, 1b Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1i
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1o Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated, 1w
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 2a Cardiomyopathy, Dilated, 1bb
Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1ff
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1kk Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 2c Autoimmune Cardiomyopathy
Dilated Cardiomyopathy 1t Dilated Cardiomyopathy
Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines

Diseases related to Autoimmune Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 combined immunodeficiency 29.2 LCK ICOSLG FYN CTLA4 CD28
2 immune deficiency disease 28.9 PDCD1 LCK ICOSLG CTLA4 CD28
3 autoimmune disease 28.7 PDCD1 LCK ICOSLG CTLA4 CD28
4 atrial standstill 1 10.3
5 cd45 deficiency 10.3 LCK FYN
6 co-trimoxazole allergy 10.3 LCK FYN
7 dilated cardiomyopathy 10.2
8 immunodeficiency 13 10.2 LCK ICOSLG
9 primary cutaneous diffuse large b-cell lymphoma, leg type 10.2 PDCD1LG2 CD274
10 primary mediastinal large b-cell lymphoma 10.2 PDCD1LG2 CD274
11 gray zone lymphoma 10.1 PDCD1LG2 CD274
12 autoimmune peripheral neuropathy 10.1 ICOSLG CD28
13 immunodeficiency 16 10.1 ICOSLG CD28
14 autoimmune glomerulonephritis 10.1 ICOSLG CTLA4
15 urinary schistosomiasis 10.1 ICOSLG CTLA4
16 autoimmune disease of eyes, ear, nose and throat 10.1 ICOSLG CTLA4
17 relapsed/refractory diffuse large b-cell lymphoma 10.0 CTLA4 CD28
18 inflammatory bowel disease 18 10.0 CTLA4 CD28
19 sialadenitis 10.0 ICOSLG CD28
20 mixed oligodendroglioma-astrocytoma 10.0 PDCD1 CD274
21 anemia, autoimmune hemolytic 10.0 ICOSLG CTLA4
22 igg4-related disease 10.0 PDCD1 ICOSLG
23 autoimmune disease of blood 9.9 ICOSLG CTLA4
24 severe combined immunodeficiency 9.9
25 myocarditis 9.9
26 lymphoepithelioma-like carcinoma 9.9 PDCD1 CD274
27 chickenpox 9.9 ICOSLG CTLA4
28 extrinsic cardiomyopathy 9.9 ICOSLG CTLA4 CD274
29 thymoma 9.9 LCK CTLA4 CD274
30 thyroid gland disease 9.9 ICOSLG CTLA4 CD274
31 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9 ICOSLG CTLA4 CD28
32 t cell deficiency 9.9 ICOSLG CTLA4 CD28
33 sympathetic ophthalmia 9.9 PDCD1 CTLA4
34 hypotrichosis 1 9.9 ICOSLG CTLA4 CD28
35 integumentary system disease 9.9 ICOSLG CTLA4 CD274
36 primary bacterial infectious disease 9.9 ICOSLG CTLA4 CD28
37 leukocyte disease 9.9 ICOSLG CTLA4 CD28
38 autoimmune disease of central nervous system 9.9 ICOSLG CTLA4 CD28
39 autoimmune disease of the nervous system 9.8 ICOSLG CTLA4 CD28
40 autoimmune disease of musculoskeletal system 9.8 ICOSLG CTLA4 CD28
41 testicular lymphoma 9.8 PDCD1LG2 PDCD1 CD274
42 gastroesophageal junction adenocarcinoma 9.8 PDCD1LG2 PDCD1 CD274
43 granulomatosis with polyangiitis 9.8 ICOSLG CTLA4 CD28
44 bone inflammation disease 9.8 ICOSLG CTLA4 CD28
45 peripartum cardiomyopathy 9.8 PDCD1 CD274 ADRB1
46 autoimmune lymphoproliferative syndrome 9.8 ICOSLG CTLA4 CD28
47 graves' disease 9.8 ICOSLG CTLA4 CD28
48 thymus gland disease 9.8 LCK ICOSLG CTLA4 CD274
49 thymus cancer 9.8 LCK ICOSLG CTLA4 CD274
50 human immunodeficiency virus infectious disease 9.8 PDCD1 ICOSLG CD28

Graphical network of the top 20 diseases related to Autoimmune Cardiomyopathy:



Diseases related to Autoimmune Cardiomyopathy

Symptoms & Phenotypes for Autoimmune Cardiomyopathy

MGI Mouse Phenotypes related to Autoimmune Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.23 ADRB1 CD28 CTLA4 FYN LCK PDCD1

Drugs & Therapeutics for Autoimmune Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Cardiomyopathy

Genetic Tests for Autoimmune Cardiomyopathy

Anatomical Context for Autoimmune Cardiomyopathy

Publications for Autoimmune Cardiomyopathy

Articles related to Autoimmune Cardiomyopathy:

(show all 38)
# Title Authors PMID Year
1
The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. 61
29333691 2018
2
Life-threatening Autoimmune Cardiomyopathy Reproducibly Induced in a Patient by Checkpoint Inhibitor Therapy. 61
29077601 2018
3
A humanized HLA-DR4 mouse model for autoimmune myocarditis. 61
28431892 2017
4
Cardiomyopathy - An approach to the autoimmune background. 61
28163240 2017
5
MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression. 61
28276515 2017
6
Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-β1-adrenergic receptor antibody neutralization and of immune parameters. 61
22968742 2012
7
Myocarditis: early biopsy allows for tailored regenerative treatment. 61
22685492 2012
8
Interleukin-6-deficient mice resist development of experimental autoimmune cardiomyopathy induced by immunization of β1-adrenergic receptor. 61
21334079 2012
9
Analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in anti-CD4 monoclonal antibody treated mice with autoimmune cardiomyopathy. 61
18704301 2008
10
Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. 61
18586265 2008
11
Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. 61
17545481 2007
12
A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse autoimmune cardiomyopathy. 61
17711737 2007
13
Nonischemic cardiomyopathy associated with autoimmune polyglandular syndrome type II. 61
17360303 2007
14
Treatment of experimental myocarditis via modulation of the renin-angiotensin system. 61
17506715 2007
15
Analysis of IgG subclass antibodies and expression of T-Cell receptor signaling molecules in anti-CD4 monoclonal antibody treated mice with autoimmune cardiomyopathy. 61
17060024 2006
16
Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function. 61
16780870 2006
17
Histochemical and enzymehistochemical alterations during experimental cardiomyopathy. 61
16783088 2006
18
Transfer of immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) mice induces cardiomyopathic changes. 61
16698668 2006
19
[Ultrastructural peculiarities of heart of rats of various ages at different levels of antigen load]. 61
16636396 2006
20
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. 61
16352741 2005
21
[Effects of immunotherapy with anti-L3T4 monoclonal antibody on autoimmune cardiomyopathy: experiment with mice]. 61
16409842 2005
22
Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency mice. 61
14871038 2003
23
Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice. 61
14570980 2003
24
Is cardiomyopathy an autoimmune disease? 61
12528926 2002
25
Acute autoimmune cardiomyopathy in primary antiphospholipid antibody syndrome. 61
12002935 2002
26
Beneficial effect of muscarinic-2 antagonist on dilated cardiomyopathy induced by autoimmune mechanism against muscarinic-2 receptor. 61
11811358 2001
27
Prevention of experimental autoimmune cardiomyopathy in rabbits by receptor blockers. 61
11908781 2001
28
Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits. 61
10904850 2000
29
Beneficial effect of angiotensin-converting enzyme inhibitor on dilated cardiomyopathy induced by autoimmune mechanism against beta1-adrenoceptor. 61
11206719 2000
30
[Energy metabolism and myocardial ultrastructure in autoimmune cardiomyopathy]. 61
3801617 1986
31
[Various regulatory properties of fructose-1,6-diphosphatase of the rat liver under normal conditions and in experimental autoimmune cardiomyopathy]. 61
3014737 1986
32
[Role of the sarcolemma in the morphogenesis of acute heart failure]. 61
6234004 1984
33
[Disruption of hydrolytic decomposition of glycogens in the liver of rats with experimental autoimmune cardiomyopathies]. 61
6608176 1983
34
[Histological, electron microscopic and biochemical study of the rat liver in experimental cardiomyopathy]. 61
7011276 1981
35
[Characteristics of glycogen metabolic regulation in rats with experimental autoimmune cardiomyopathy]. 61
382627 1979
36
[Effect of physical overloads on the state of the cardiomyocytes in experimental autoimmune cardiomyopathy]. 61
426643 1979
37
[Experimental autoimmune cardiomyopathies in several generations of animals]. 61
142173 1977
38
[Ultrastructure of the myocardium in experimental autoimmune cardiomyopathy]. 61
1023848 1976

Variations for Autoimmune Cardiomyopathy

Expression for Autoimmune Cardiomyopathy

Search GEO for disease gene expression data for Autoimmune Cardiomyopathy.

Pathways for Autoimmune Cardiomyopathy

Pathways related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 PDCD1LG2 PDCD1 LCK ICOSLG HSPA5 FYN
2
Show member pathways
13.15 PDCD1LG2 PDCD1 LCK ICOSLG HSPA5 FYN
3
Show member pathways
12.63 ICOSLG HSPA5 FYN CTLA4 CD28
4
Show member pathways
12.42 PDCD1 LCK FYN CTLA4 CD28 CD274
5
Show member pathways
12.41 LCK ICOSLG FYN CD28
6 12.36 PDCD1LG2 PDCD1 LCK CTLA4 CD28 CD274
7
Show member pathways
12.23 LCK ICOSLG FYN CTLA4 CD28
8 11.91 PDCD1LG2 PDCD1 ICOSLG CTLA4 CD28 CD274
9
Show member pathways
11.82 PDCD1LG2 PDCD1 LCK CD274
10
Show member pathways
11.75 LCK FYN CD28
11
Show member pathways
11.64 LCK FYN CD28
12 11.59 LCK FYN CTLA4 CD28
13
Show member pathways
11.46 PDCD1LG2 PDCD1 LCK ICOSLG FYN CTLA4
14 11.25 PDCD1LG2 PDCD1 ICOSLG CTLA4 CD28 CD274
15 11.12 LCK CD28
16 11.1 LCK FYN
17 11.05 PDCD1 LCK FYN CTLA4 CD28
18 11.02 LCK FYN
19 11.01 LCK FYN
20 10.98 LCK FYN
21 10.76 LCK FYN

GO Terms for Autoimmune Cardiomyopathy

Cellular components related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10 PDCD1LG2 PDCD1 LCK ICOSLG HSPA5 FYN
2 plasma membrane GO:0005886 9.7 PDCD1LG2 PDCD1 LCK ICOSLG HSPA5 FYN
3 protein complex involved in cell adhesion GO:0098636 9.16 CTLA4 CD28
4 external side of plasma membrane GO:0009897 9.1 PDCD1LG2 PDCD1 ICOSLG CTLA4 CD28 CD274

Biological processes related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.84 PDCD1LG2 CTLA4 CD28 CD274
2 immune system process GO:0002376 9.8 PDCD1LG2 PDCD1 ICOSLG FYN CTLA4 CD274
3 cell surface receptor signaling pathway GO:0007166 9.73 PDCD1LG2 FYN CD28 CD274
4 positive regulation of protein kinase B signaling GO:0051897 9.72 LCK FYN CD28
5 adaptive immune response GO:0002250 9.63 PDCD1LG2 PDCD1 ICOSLG FYN CTLA4 CD274
6 positive regulation of T cell proliferation GO:0042102 9.58 PDCD1LG2 CD28 CD274
7 positive regulation of interleukin-10 production GO:0032733 9.57 CD28 CD274
8 peptidyl-tyrosine autophosphorylation GO:0038083 9.56 LCK FYN
9 negative regulation of T cell proliferation GO:0042130 9.54 PDCD1LG2 CTLA4 CD274
10 negative regulation of interleukin-10 production GO:0032693 9.52 PDCD1LG2 CD274
11 negative regulation of activated T cell proliferation GO:0046007 9.51 PDCD1LG2 CD274
12 regulation of regulatory T cell differentiation GO:0045589 9.49 CTLA4 CD28
13 negative regulation of immune response GO:0050777 9.48 PDCD1 CTLA4
14 regulation of T cell proliferation GO:0042129 9.46 CTLA4 CD28
15 regulation of defense response to virus by virus GO:0050690 9.43 LCK FYN CD28
16 T cell receptor signaling pathway GO:0050852 9.35 LCK ICOSLG FYN CTLA4 CD28
17 T cell costimulation GO:0031295 9.23 PDCD1LG2 PDCD1 LCK ICOSLG FYN CTLA4

Molecular functions related to Autoimmune Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase binding GO:0043548 9.26 LCK FYN
2 T cell receptor binding GO:0042608 9.16 LCK FYN
3 CD4 receptor binding GO:0042609 8.96 LCK FYN
4 CD8 receptor binding GO:0042610 8.62 LCK FYN

Sources for Autoimmune Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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