MCID: ATM113
MIFTS: 30

Autoimmune Cholangitis

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Autoimmune Cholangitis

MalaCards integrated aliases for Autoimmune Cholangitis:

Name: Autoimmune Cholangitis 12 15
Autoimmune Cholangiopathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080742

Summaries for Autoimmune Cholangitis

Disease Ontology : 12 An autoimmune hepatitis that is characterized by primary biliary cirrhosis clinical, biochemical, and histologic characteristics with antinuclear antibody positive sera.

MalaCards based summary : Autoimmune Cholangitis, also known as autoimmune cholangiopathy, is related to cholangitis and autoimmune hepatitis. An important gene associated with Autoimmune Cholangitis is DLAT (Dihydrolipoamide S-Acetyltransferase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include liver, t cells and lymph node.

Related Diseases for Autoimmune Cholangitis

Diseases in the Cholangitis family:

Autoimmune Cholangitis Acute Cholangitis
Chronic Cholangitis

Diseases related to Autoimmune Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.2 SP100 NUP210 GGT1 DLAT ABCB4
2 autoimmune hepatitis 30.7 SEPSECS IL17A GGT1 DLAT
3 chronic cholangitis 30.2 SP100 DLAT ABCB4
4 liver disease 29.9 SEPSECS IFNA2 GGT1 DLAT ABCB4
5 colitis 29.6 IL23A IL17A CD4 CCR6
6 celiac disease 1 29.5 IL17A CD8A CD4 CCR6
7 anemia, autoimmune hemolytic 29.5 CD8A CD4 CCR6
8 dacryoadenitis 29.3 IL17A CD8A CD4 CCR6
9 primary biliary cholangitis 29.1 SP100 SEPSECS NUP210 GGT1 DLAT DBT
10 cholangitis, primary sclerosing 28.4 SP100 SEPSECS NUP210 IL17A GGT1 DLAT
11 liver cirrhosis 10.6
12 cholestasis 10.4
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
14 cutaneous candidiasis 10.3 IL17A CCR6
15 parenteral nutrition-associated cholestasis 10.3 GGT1 ABCB4
16 sclerosing cholangitis 10.3
17 autoimmune disease 10.3
18 pustulosis of palm and sole 10.2 IL17A CCR6
19 cholangiocarcinoma 10.2
20 intrahepatic cholangiocarcinoma 10.2
21 halothane hepatitis 10.2 SEPSECS DLAT
22 crest syndrome 10.2 SP100 NUP210
23 inflammatory bowel disease 18 10.2 IL17A CCR6
24 autoimmune polyendocrine syndrome 10.2 IL23A IL17A CCR6
25 spondylitis 10.2 IL23A IL17A CCR6
26 reactive arthritis 10.2 IL23A IL17A CCR6
27 autoimmune pancreatitis 10.1
28 suppurative cholangitis 10.1 SEPSECS DLAT ABCB4
29 relapsing-remitting multiple sclerosis 10.1 IL23A IL17A CCR6
30 vogt-koyanagi-harada disease 10.1 IL17A IFNA2 CD8A
31 inflammatory bowel disease 10.1
32 sialadenitis 10.1
33 hepatitis 10.1
34 asymptomatic neurosyphilis 10.1 IL17A CD4
35 meningovascular neurosyphilis 10.1 IL17A CD4
36 transient arthritis 10.1 IL17A CD4
37 geniculate ganglionitis 10.0 IFNA2 CD4
38 scabies 10.0 CD4 CCR6
39 hypopyon 10.0 IL17A CD4
40 trichinosis 10.0 IL17A CD4
41 aortitis 10.0 IL17A CD4
42 timothy grass allergy 10.0 IL17A CD4
43 viral hepatitis 10.0 SEPSECS IFNA2 GGT1
44 suppurative lymphadenitis 10.0 CD4 CCR6
45 myositis 10.0
46 pancreatitis 10.0
47 thyroiditis 10.0
48 herpes simplex virus keratitis 10.0 CD4 CCR6
49 mikulicz disease 10.0 CD4 CCR6
50 cork-handlers' disease 10.0 CD8A CD4

Graphical network of the top 20 diseases related to Autoimmune Cholangitis:



Diseases related to Autoimmune Cholangitis

Symptoms & Phenotypes for Autoimmune Cholangitis

Drugs & Therapeutics for Autoimmune Cholangitis

Search Clinical Trials , NIH Clinical Center for Autoimmune Cholangitis

Genetic Tests for Autoimmune Cholangitis

Anatomical Context for Autoimmune Cholangitis

MalaCards organs/tissues related to Autoimmune Cholangitis:

40
Liver, T Cells, Lymph Node, Heart, Thyroid, Salivary Gland, Monocytes

Publications for Autoimmune Cholangitis

Articles related to Autoimmune Cholangitis:

(show top 50) (show all 260)
# Title Authors PMID Year
1
Enoxacin upregulates microRNA biogenesis and downregulates cytotoxic CD8 T cell function in autoimmune cholangitis. 61
33462854 2021
2
Nanoparticle-mediated targeting of autoantigen peptide to cross-presenting liver sinusoidal endothelial cells protects from CD8 T-cell-driven autoimmune cholangitis. 61
33346377 2020
3
IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression. 61
33197512 2020
4
Glycomic analysis of antibody indicates distinctive glycosylation profile in patients with autoimmune cholangitis. 61
32546343 2020
5
Treatment of Overlap Syndromes in Autoimmune Liver Disease: A Systematic Review and Meta-Analysis. 61
32414025 2020
6
Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4+ T cells. 61
30874628 2020
7
Invasive Hepatobiliary Trichosporon asahii Infection in a Child With Autoimmune Cholangitis. 61
31107957 2019
8
HLA-DRB1 GENE POLYMORPHISMS IN PEDIATRIC PATIENTS WITH TYPE 1 AUTOIMMUNE HEPATITIS AND TYPE 1 AUTOIMMUNE HEPATITIS OVERLAP SYNDROME WITH AUTOIMMUNE CHOLANGITIS. 61
31460577 2019
9
Mig chemokine in primary biliary cirrhosis. 61
31173052 2019
10
[Is autoimmune cholangitis-anti-mitochondrial antibody-negative primary biliary cholangitis still an independent disease?] 61
31177668 2019
11
Gal-3 Deficiency Suppresses Novosphyngobium aromaticivorans Inflammasome Activation and IL-17 Driven Autoimmune Cholangitis in Mice. 61
31231399 2019
12
Sarcoidosis of the Intra- and Extrahepatic Bile Ducts with Concomitant Cholangitis in a Patient with Ulcerative Colitis. 61
31097931 2019
13
Gut microbiota translocation promotes autoimmune cholangitis. 61
30340822 2018
14
Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis. 61
30274824 2018
15
Type 1 and Type 2 Autoimmune Pancreatitis: Distinctive Clinical and Pathological Features, But Are There Any Differences at Magnetic Resonance? Experience From a Referral Center. 61
30141780 2018
16
Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9. 61
30223894 2018
17
Proteomic analysis reveals distinctive protein profiles involved in CD8+ T cell-mediated murine autoimmune cholangitis. 61
29375127 2018
18
The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity. 61
28921595 2018
19
A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis. 61
29158418 2018
20
The CXC Chemokine Receptor 3 Inhibits Autoimmune Cholangitis via CD8+ T Cells but Promotes Colitis via CD4+ T Cells. 61
29868034 2018
21
[Primary biliary cholangitis. Part 2. State of the art, diagnosis, associated diseases, treatment and prognosis]. 61
29791424 2018
22
The Critical Role of Chemokine (C-C Motif) Receptor 2-Positive Monocytes in Autoimmune Cholangitis. 61
30158929 2018
23
A Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization. 61
29127360 2017
24
[Autoimmune hepatitis: Immunological diagnosis]. 61
28919271 2017
25
[Primary biliary cholangitis. Part 1. State of the art, epidemiology, physiopathology and clinical manifestations]. 61
29459807 2017
26
The clinical extremes of autoimmune cholangitis. 61
28376623 2017
27
Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8+ T cell activation. 61
28129932 2017
28
Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience. 61
28348580 2017
29
Diagnosis and Treatment of Autoimmune Liver Diseases in a Tertiary Referral Center in Cuba. 61
29158853 2017
30
Galectin-3 regulates inflammasome activation in cholestatic liver injury. 61
27630169 2016
31
The diagnosis of antimitochondrial antibody-negative primary biliary cholangitis. 61
27567165 2016
32
Prevalence of IgG-4-associated cholangiopathy based on serum IgG-4 levels in patients with primary sclerosing cholangitis and its relationship with inflammatory bowel disease. 61
27852547 2016
33
Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance. 61
27178326 2016
34
Dual Roles of IFN-γ and IL-4 in the Natural History of Murine Autoimmune Cholangitis: IL-30 and Implications for Precision Medicine. 61
27721424 2016
35
Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice. 61
27148790 2016
36
Dysregulation of peritoneal cavity B1a cells and murine primary biliary cholangitis. 61
27105495 2016
37
Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens. 61
26996208 2016
38
Celiac disease-related hepatic injury: Insights into associated conditions and underlying pathomechanisms. 61
26711682 2016
39
AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis. 61
26537567 2016
40
Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy. 61
26432598 2016
41
[Syndrome overlap: autoimmune hepatitis and autoimmune cholangitis]. 61
27131945 2016
42
Diagnostic performance of imaging criteria for distinguishing autoimmune cholangiopathy from primary sclerosing cholangitis and bile duct malignancy. 61
26350286 2015
43
Benign Biliary Strictures and Leaks. 61
26431599 2015
44
CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis. 61
26396175 2015
45
The coexistence of Sjögren's syndrome and primary biliary cirrhosis: a comprehensive review. 61
25682089 2015
46
Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis. 61
25581259 2015
47
Importance of Abdominal Ultrasound in 17 Patients with Histologically Confirmed Autoimmune Pancreatitis (AIP). 61
25377446 2015
48
Adoptive cell transfer in autoimmune hepatitis. 61
25719553 2015
49
A Case of Autoimmune Cholangitis Misdiagnosed for Cholangiocarcinoma: How to Avoid Unnecessary Surgical Intervention? 61
26259410 2015
50
Tumor Necrosis Factor-Alpha at the Crossroad between Rheumatoid Arthritis and Autoimmune Cholangitis. 61
26223089 2015

Variations for Autoimmune Cholangitis

Expression for Autoimmune Cholangitis

Search GEO for disease gene expression data for Autoimmune Cholangitis.

Pathways for Autoimmune Cholangitis

GO Terms for Autoimmune Cholangitis

Cellular components related to Autoimmune Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 TGFBR2 IL17A CD8A CD4 CCR6

Biological processes related to Autoimmune Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.85 LGALS9 IL23A IL17A CD8A CD4
2 inflammatory response GO:0006954 9.78 LGALS9 IL23A IL17A IFNA2
3 cytokine-mediated signaling pathway GO:0019221 9.71 IL23A IL17A IFNA2 CD4
4 immune response GO:0006955 9.55 IL23A IL17A CD8A CD4 CCR6
5 positive regulation of tumor necrosis factor production GO:0032760 9.54 LGALS9 IL23A IL17A
6 defense response to Gram-negative bacterium GO:0050829 9.5 IL23A IL17A CD4
7 positive regulation of viral entry into host cell GO:0046598 9.43 LGALS9 CD4
8 positive regulation of dendritic cell chemotaxis GO:2000510 9.26 LGALS9 CCR6
9 positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 8.96 TGFBR2 LGALS9
10 positive regulation of interleukin-12 production GO:0032735 8.8 LGALS9 IL23A IL17A

Sources for Autoimmune Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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