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MCID: ATM095
MIFTS: 65

Autoimmune Disease

Categories: Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Autoimmune Disease

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MalaCards integrated aliases for Autoimmune Disease:

Name: Autoimmune Disease 57 12 29
Autoimmune Diseases 55 43 73
Autoimmune Hypersensitivity Disease 12 15
Hypersensitivity Reaction Type Ii Disease 12
Autoimmune Disorder 15

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant gene epistatic to other secondary genes conferring specificity to the autoimmune phenotype


Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 109100
Disease Ontology 12 DOID:417
ICD9CM 35 720
MedGen 42 C0004364
Sources

Summaries for Autoimmune Disease

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MedlinePlus : 43 Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body. No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases. There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards based summary : Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and autoimmune disease of the nervous system. An important gene associated with Autoimmune Disease is GAS5 (Growth Arrest Specific 5), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and thyroid, and related phenotypes are autoimmune antibody positivity and hematopoietic system

Disease Ontology : 12 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.

Wikipedia : 76 An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.... more...

Description from OMIM: 109100
Sources

Related Diseases for Autoimmune Disease

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Diseases related to Autoimmune Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 712)
# Related Disease Score Top Affiliating Genes
1 vitiligo-associated multiple autoimmune disease susceptibility 1 34.4 PTPN22 NLRP1 CTLA4 AIRE
2 autoimmune disease of the nervous system 33.9 TNF MBP IL17A IL10 IFNG
3 autoimmune disease of endocrine system 33.7 PTPN22 IFNG CTLA4 AIRE
4 autoimmune disease of eyes, ear, nose and throat 33.6 TNF IL17A IL10
5 autoimmune disease of musculoskeletal system 33.6 TNFSF13B TNF PTPN22 IL17A IL10 APOH
6 autoimmune disease of central nervous system 33.6 TNF MBP IL17A IL10 IFNG
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 33.1 TNFSF13B PTPN22 IL17A IL10 IFNG CTLA4
8 hashimoto thyroiditis 32.7 PTPN22 IFNG CTLA4 AIRE
9 lupus erythematosus 32.7 TNF PTPN22 NLRP1 IL10 CTLA4 APOH
10 celiac disease 1 32.6 TNF PTPN22 IL10 IFNG CTLA4
11 rheumatoid arthritis 32.5 TNFSF13B TNF PTPN22 NLRP1 IL17A IL10
12 multiple sclerosis 32.5 TNFSF13B TNF MBP IL17A IL10 IFNG
13 systemic lupus erythematosus 32.5 TNFSF13B TNF PTPN22 NLRP1 IL17A IL10
14 mixed connective tissue disease 32.4 TNF IL10 IFNG APOH
15 neuromyelitis optica 32.4 TNFSF13B MBP IL17A
16 alopecia areata 32.3 TNF PTPN22 IL17A IFNG CTLA4 AIRE
17 autoimmune pancreatitis 32.2 TNFSF13B IL10 ENO1 CTLA4
18 myasthenia gravis 32.2 TNFSF13B TNF MBP IL10 IFNG CTLA4
19 psoriasis 32.2 IFNG IL10 IL17A PTPN22 TNF
20 diabetes mellitus, insulin-dependent 32.2 PTPN22 IL10 IFNG CTLA4 AIRE
21 autoimmune uveitis 32.2 TNF IL17A IL10 IFNG
22 vogt-koyanagi-harada disease 32.2 IL10 IL17A NLRP1 PTPN22
23 behcet syndrome 32.2 TNF IL17A IL10 IFNG ENO1 CTLA4
24 autoimmune myocarditis 32.1 IFNG TNF
25 interstitial lung disease 31.8 IFNG IL10 TNF
26 autoimmune addison disease 31.7 NLRP1 CTLA4 AIRE
27 punctate inner choroidopathy 31.7 TNF IL10
28 reactive arthritis 31.7 TNF IL17A IL10 IFNG
29 melioidosis 31.7 IFNG IL10 TNF
30 autoimmune retinopathy 31.7 AIRE ENO1
31 autoimmune optic neuritis 31.7 MBP IL17A IL10
32 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 31.6 AIRE IFNG IL10
33 autoimmune atherosclerosis 31.6 APOH IL10
34 microscopic polyangiitis 31.6 IL10 TNF
35 immune system disease 31.6 TNFSF13B TNF MBP IL17A IL10 IFNG
36 arthritis 31.2 TNF PTPN22 NLRP1 IL17A IL10 IFNG
37 hematopoietic stem cell transplantation 30.9 TNF IL10 IFNG CTLA4
38 vasculitis 30.8 APOH TNF TNFSF13B
39 uveitis 30.6 TNF IL17A IL10 IFNG CTLA4
40 colitis 30.6 CTLA4 IFNG IL10 IL17A TNF
41 connective tissue disease 30.6 APOH IFNG IL10 TNF TNFSF13B
42 ulcerative colitis 30.5 TNF IL17A IL10 IFNG
43 graft-versus-host disease 30.3 IFNG IL10 TNF
44 chronic graft versus host disease 30.3 TNFSF13B TNF IL10 IFNG
45 dermatitis, atopic 30.3 IFNG IL10 IL17A TNF
46 temporal arteritis 30.3 TNF PTPN22 IFNG APOH
47 common variable immunodeficiency 30.3 TNFSF13B TNF IL10 IFNG CTLA4
48 hemophagocytic lymphohistiocytosis 30.2 TNF IL10 IFNG CTLA4
49 inflammatory bowel disease 30.2 TNF STAT3 PTPN22 IL17A IL10 IFNG
50 myeloma, multiple 30.2 GAS5 STAT3 TNF TNFSF13B

Graphical network of the top 20 diseases related to Autoimmune Disease:



Diseases related to Autoimmune Disease
Sources

Symptoms & Phenotypes for Autoimmune Disease

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Symptoms via clinical synopsis from OMIM:

57
Immunology:
autoimmune disease

Lab:
high titer autoantibody


Clinical features from OMIM:

109100

Human phenotypes related to Autoimmune Disease:

32
# Description HPO Frequency HPO Source Accession
1 autoimmune antibody positivity 32 HP:0030057

MGI Mouse Phenotypes related to Autoimmune Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 AIRE CTLA4 IFNG IL10 IL17A ITCH
2 homeostasis/metabolism MP:0005376 10.03 AIRE APOH CTLA4 IFNG IL10 IL17A
3 digestive/alimentary MP:0005381 9.97 AIRE CTLA4 IFNG IL10 IL17A PTPN22
4 immune system MP:0005387 9.97 AIRE CTLA4 IFNG IL10 IL17A ITCH
5 liver/biliary system MP:0005370 9.5 AIRE CTLA4 IFNG IL10 PTPN22 STAT3
6 respiratory system MP:0005388 9.28 AIRE CTLA4 IFNG IL10 IL17A ITCH
Sources

Drugs & Therapeutics for Autoimmune Disease

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Drugs for Autoimmune Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1192)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
2
Ledipasvir Approved Phase 4 1256388-51-8 67505836
3
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 79902-63-9 54454
4
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Not Applicable 9004-61-9 53477741
5
Azithromycin Approved Phase 4,Phase 2,Phase 1 83905-01-5 55185 447043
6
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
7
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7782-49-2
8
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
11
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492
12
Everolimus Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 159351-69-6 6442177
13
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24280-93-1 446541
14
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
15
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
16
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
17
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
18 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
20
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6
21
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
22
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 116094-23-6 16132418
23
Enalapril Approved, Vet_approved Phase 4,Phase 2,Not Applicable 75847-73-3 5362032 40466924
24
Enalaprilat Approved Phase 4,Phase 2,Not Applicable 76420-72-9 6917719
25
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
26
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
27
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53608-75-6
28
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
29
Losartan Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 114798-26-4 3961
30
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
31
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
32
Glyburide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10238-21-8 3488
33
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
34
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
35
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 189261-10-7
36
4-Aminopyridine Approved Phase 4,Phase 3,Phase 2,Not Applicable 504-24-5 1727
37
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 65271-80-9 4212
38
Interferon beta-1b Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 145155-23-3
39
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 141758-74-9 15991534
40
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
41
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 332348-12-6 10237
42
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
43
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 599-79-1 5353980 5359476
44
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
45
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118-42-3 3652
46
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
47
Diazoxide Approved Phase 4 364-98-7 3019
48
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
49
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
50
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 15307-86-5 3033

Interventional clinical trials:

(show top 50) (show all 8822)
# Name Status NCT ID Phase Drugs
1 Study to Investigate the Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With Chronic Genotype 1 and 4 HCV Infection With Autoimmune Disease Unknown status NCT02691728 Phase 4 LDV/SOF FDC
2 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
3 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
4 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
5 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
6 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
7 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
8 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
9 Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial Unknown status NCT01679561 Phase 4 intralipid
10 Probiotics in Newly Recognized Type 1 Diabetes Unknown status NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
11 Acthar for the Treatment of Systemic Lupus Erythematosus in Patients With a History of Persistently Active Disease Unknown status NCT01753401 Phase 4 Acthar;Placebo for Acthar
12 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
13 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
14 Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy Unknown status NCT02981212 Phase 4 Mycophenolate Mofetil;ACE inhibitor;Corticosteroid;ARB
15 Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps. Unknown status NCT02685449 Phase 4 Insulin glulisine;Insulin aspart;Insulin lispro
16 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
17 The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes Unknown status NCT02307695 Phase 4 Saxagliptin;Insulin
18 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
19 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
20 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
21 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
22 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
23 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
24 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
25 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
26 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
27 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
28 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
29 Methylprednisolone During the Switch Between Natalizumab and Fingolimod Unknown status NCT02769689 Phase 4 Methylprednisolone;Placebo;natalizumab (NTZ);fingolimob (FTY)
30 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
31 Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya Unknown status NCT02325440 Phase 4 Fingolimod;Natalizumab
32 Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS Unknown status NCT02259361 Phase 4 Sustained-release oral dalfampridine;Placebo
33 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
34 Impact of Vitamin A on RAR Gene Expression in Multiple Sclerosis Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
35 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
36 Impact of Vitamin A on Multiple Sclerosis (MS) Unknown status NCT01417273 Phase 4 Drug: placebo
37 Impact of Vitamin A on Gene Expression, in Multiple Sclerosis Patient Unknown status NCT01407211 Phase 4
38 Colecalciferol as an Add-on Treatment to Interferon-beta-1b for Treatment of Multiple Sclerosis (MS) Unknown status NCT01339676 Phase 4 Colecalciferol;Placebo capsules
39 Optical Coherence Tomography: Glatiramer in Clinically Isolated Syndrome or Early Relapsing Remitting Multiple Sclerosis (MS) Unknown status NCT00910598 Phase 4 glatiramer acetate
40 Phase IV Study, Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI Unknown status NCT00176592 Phase 4 Betaseron;Copaxone
41 IVIg for Demyelination in Diabetes Mellitus Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
42 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
43 An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes Unknown status NCT02962492 Phase 4 Exenatide/Exenatide extended release;Dapagliflozin;Placebo
44 The Clinical Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months Treatment Unknown status NCT02837978 Phase 4 Tacrolimus;MTX
45 Inhibition of Co-Stimulation in Rheumatoid Arthritis Unknown status NCT02652273 Phase 4 Abatacept
46 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
47 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
48 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4 Dapagliflozin
49 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
50 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide

Search NIH Clinical Center for Autoimmune Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Autoimmune Disease

About this section

Genetic tests related to Autoimmune Disease:

# Genetic test Affiliating Genes
1 Autoimmune Disease 29
Sources

Anatomical Context for Autoimmune Disease

About this section

MalaCards organs/tissues related to Autoimmune Disease:

41
T Cells, B Cells, Thyroid, Bone, Lung, Kidney, Eye
Sources

Publications for Autoimmune Disease

About this section

Articles related to Autoimmune Disease:

(show top 50) (show all 3197)
# Title Authors Year
1
The pathogenesis of thyroid autoimmune diseases: New T lymphocytes - Cytokines circuits beyond the Th1-Th2 paradigm. ( 30246383 )
2019
2
Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases? ( 30502748 )
2019
3
Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis. ( 29642198 )
2018
4
Anti-microbial Antibodies, Host Immunity, and Autoimmune Disease. ( 29876352 )
2018
5
Regulatory T cells in autoimmune disease. ( 29925983 )
2018
6
Autoimmune Diseases in Patients With Cutaneous Lupus Erythematosus. ( 29801110 )
2018
7
Myasthenia gravis: the unmet needs of a paradigmatic autoimmune disease. ( 29943694 )
2018
8
A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease. ( 29854851 )
2018
9
Autoimmune-Disease-Prone NOD Mice Help To Reveal a New Genetic Locus for Reducing Pulmonary Disease Caused by Mycoplasma pulmonis. ( 29263105 )
2018
10
TNF Receptor Type II as an Emerging Drug Target for the Treatment of Cancer, Autoimmune Diseases, and Graft-Versus-Host Disease: Current Perspectives and <i>In Silico</i> Search for Small Molecule Binders. ( 29967617 )
2018
11
Association of Stress-Related Disorders With Subsequent Autoimmune Disease. ( 29922828 )
2018
12
The risk of alopecia areata and other related autoimmune diseases in patients with sleep disorders: a Korean population-based retrospective cohort study. ( 29955877 )
2018
13
Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort. ( 28755788 )
2018
14
Coexistent sickle-cell anemia and autoimmune disease in eight children: pitfalls and challenges. ( 29343274 )
2018
15
Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients. ( 29930297 )
2018
16
Autoimmune disease: Targeting glucose transport in psoriasis. ( 29844603 )
2018
17
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. ( 29422534 )
2018
18
Autoimmune disease: Aryl hydrocarbon receptor suppresses inflammation. ( 29950706 )
2018
19
Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase. ( 29440417 )
2018
20
Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease. ( 29560011 )
2018
21
Pharmacokinetics and C-reactive protein modelling of anti-interleukin-6 antibody (PF-04236921) in healthy volunteers and patients with autoimmune disease. ( 29776017 )
2018
22
Autoimmune disease, familial clustering and thyroid carcinoma coexistent with autoimmune thyroiditis in children and adolescence: A cross-sectional study from the Czech Republic. ( 29936527 )
2018
23
Impact of Dietary Cholesterol on the Pathophysiology of Infectious and Autoimmune Disease. ( 29899295 )
2018
24
Molecular mimicry: An explanation for autoimmune diseases and infertility. ( 29935034 )
2018
25
How does autoimmune disease impact treatment and outcomes among patients with lung cancer? A national SEER-Medicare analysis. ( 29290269 )
2018
26
Plasma Cell Depletion Attenuates Hypertension in an Experimental Model of Autoimmune Disease. ( 29378858 )
2018
27
Chagas disease and systemic autoimmune diseases among Bolivian patients in Switzerland. ( 29412344 )
2018
28
Systemic autoimmune diseases are associated with an increased risk of bipolar disorder: A nationwide population-based cohort study. ( 29049933 )
2018
29
Anorexia, coeliac and autoimmune disease. ( 29317440 )
2018
30
The influence of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitamin B12 deficiency and other comorbid autoimmune diseases on treatment outcome in patients with rheumatoid arthritis: An exploratory cohort study. ( 29794789 )
2018
31
Engineered Sialylation of Pathogenic Antibodies InA Vivo Attenuates Autoimmune Disease. ( 29275858 )
2018
32
Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy. ( 29421443 )
2018
33
Use of Immune Checkpoint Inhibitors in the Treatment of Patients With Cancer and Preexisting Autoimmune Disease: A Systematic Review. ( 29297009 )
2018
34
Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions. ( 29341431 )
2018
35
An autoimmune disease-associated risk variant in the<i>TNFAIP3</i>gene plays a protective role in brucellosis that is mediated by the NF-kappa B signaling pathway. ( 29343543 )
2018
36
Pharmacogenetics: A strategy for personalized medicine for autoimmune diseases. ( 29194620 )
2018
37
Atherosclerosis as autoimmune disease. ( 29955576 )
2018
38
Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. ( 29959280 )
2018
39
Is there an association between dipeptidyl peptidase-4 inhibitors and autoimmune disease? A population-based study. ( 29855994 )
2018
40
Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in <i>Aicda<sup>-/-</sup></i> and <i>Ung<sup>-/-</sup></i> Mice. ( 29980612 )
2018
41
Combination Therapy with Glucan and Coenzyme Q<sub>10</sub> in Murine Experimental Autoimmune Disease and Cancer. ( 29848676 )
2018
42
Clinical features and outcome of lymphoma patients with pre-existing autoimmune diseases. ( 29205866 )
2018
43
C-terminal truncation of IFN-I^ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease. ( 29925830 )
2018
44
Approaches and advances in the genetic causes of autoimmune disease and their implications. ( 29925982 )
2018
45
Characterizing Autoimmune Disease-associated Diffuse Large B-cell Lymphoma in a SEER-Medicare Cohort. ( 29273217 )
2018
46
The Importance of Sex Stratification in Autoimmune Disease Biomarker Research: A Systematic Review. ( 29915581 )
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Hypoxia-inducible factor-1I+ is a critical transcription factor for IL-10-producing B cells in autoimmune disease. ( 29343683 )
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Recurrent and universal alopecia areata following alemtuzumab treatment in multiple sclerosis: A secondary autoimmune disease. ( 30530069 )
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Mid- and Deep-Zone Gastritis: A Histologic Pattern Associated With Autoimmune Disease but Distinct From Autoimmune Atrophic Gastritis. ( 30032289 )
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Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden. ( 30407269 )
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Sources

Variations for Autoimmune Disease

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Copy number variations for Autoimmune Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21625 1 159859611 159867782 Copy number FCGR3B Autoimmune disease
2 21792 1 161592989 161601158 Copy number FCGR3B Autoimmune disease
3 21796 1 161592989 161601158 Deletion FCGR3B Autoimmune disease
4 208909 6 211050653 211252076 Copy number CYP21B Autoimmune disease
5 210508 6 30400000 36600000 Copy number CYP21A Autoimmune disease
6 210509 6 30400000 36600000 Copy number TNXA Autoimmune disease
7 211044 6 3197570 32111174 Copy number C4A Autoimmune disease
8 211046 6 3197570 32111174 Copy number C4B Autoimmune disease
Sources

Expression for Autoimmune Disease

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Search GEO for disease gene expression data for Autoimmune Disease.
Sources

Pathways for Autoimmune Disease

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Pathways related to Autoimmune Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 37
Show member pathways
 12.77 CTLA4 IFNG IL10 IL17A TNF TNFSF13B
2
Th17 cell differentiation 37
Show member pathways
 12.48 IFNG IL10 IL17A STAT3 TNF
3
Immune response IL-23 signaling pathway 22
Show member pathways
 12.47 IFNG IL10 IL17A STAT3 TNF
4
IL-17 Family Signaling Pathways 65
Show member pathways
 12.24 IFNG IL17A STAT3 TNF
5
T cell receptor signaling pathway 37
Show member pathways
 12.21 CTLA4 IFNG IL10 IL17A TNF
6
Toxoplasmosis 37
Show member pathways
 12.17 IFNG IL10 STAT3 TNF
7
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.98 IFNG IL10 IL17A STAT3 TNFSF13B
8
Spinal Cord Injury 1
11.86 IFNG MBP TNF TNFSF13B
9
NF-kappaB Signaling 4
11.84 CTLA4 IFNG IL10 IL17A ITCH NLRP1
10
Interleukin-4 and 13 signaling 66
11.81 IL10 IL17A STAT3 TNF
11
HIF-1 signaling pathway 37
11.8 ENO1 IFNG STAT3
12
Amoebiasis 37
11.78 IFNG IL10 TNF
13
Th1 Differentiation Pathway 65
Show member pathways
 11.67 IFNG IL10 IL17A STAT3 TNF
14
Dendritic Cells Developmental Lineage Pathway 65
11.66 IFNG IL10 TNF
15
Innate Lymphoid Cell Differentiation Pathways 65
11.57 IFNG IL10 IL17A TNF
16
TGF-beta Receptor Signaling (WikiPathways) 1
11.54 IFNG STAT3 TNF
17
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.5 CTLA4 IFNG ITCH TNF
18
Interleukin-10 signaling 66
11.45 IL10 STAT3 TNF
19
Malaria 37
11.44 IFNG IL10 TNF
20
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.41 IFNG IL10 IL17A TNF
21
Rheumatoid arthritis 37
11.31 CTLA4 IFNG IL17A TNF TNFSF13B
22
African trypanosomiasis 37
11.24 IFNG IL10 TNF
23
IL-10 Pathway 64
11.23 IL10 STAT3 TNF
24
Development and heterogeneity of the ILC family 1
11.18 IFNG IL17A TNF
25
G-protein signaling_RhoB regulation pathway 22
11.12 IL10 IL17A TNF TNFSF13B
26
Cytokines and Inflammatory Response 1
11.07 IFNG IL10 TNF
Sources

GO Terms for Autoimmune Disease

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Cellular components related to Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 APOH ENO1 IFNG IL10 IL17A SIAE

Biological processes related to Autoimmune Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.89 IFNG IL10 IL17A TNF TNFSF13B
2 cytokine-mediated signaling pathway GO:0019221 9.88 IL10 IL17A STAT3 TNF
3 negative regulation of gene expression GO:0010629 9.85 IFNG PTPN22 TNF ZFAT-AS1
4 response to organic substance GO:0010033 9.73 IL10 STAT3 TNF
5 humoral immune response GO:0006959 9.63 AIRE IFNG TNF
6 negative regulation of B cell proliferation GO:0030889 9.61 CTLA4 IL10
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IFNG TNF
8 regulation of regulatory T cell differentiation GO:0045589 9.59 CTLA4 IFNG
9 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL10 TNF
11 positive regulation of ATP biosynthetic process GO:2001171 9.54 ENO1 STAT3
12 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.52 IL10 MBP
13 positive regulation of metalloendopeptidase activity GO:1904685 9.51 MBP STAT3
14 endothelial cell apoptotic process GO:0072577 9.48 IL10 TNF
15 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
16 inflammatory response GO:0006954 9.43 IL10 IL17A ITCH NLRP1 STAT3 TNF
17 positive regulation of interleukin-23 production GO:0032747 9.4 IFNG IL17A
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
19 positive regulation of osteoclast differentiation GO:0045672 9.33 IFNG IL17A TNF
20 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
22 immune response GO:0006955 9.23 AIRE CTLA4 IFNG IL10 IL17A MBP
23 immune system process GO:0002376 10.01 CTLA4 ITCH NLRP1 PTPN22 TNFSF13B

Molecular functions related to Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL10 IL17A TNF TNFSF13B
Sources

Sources for Autoimmune Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN