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MCID: ATM095
MIFTS: 68

Autoimmune Disease

Categories: Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Autoimmune Disease

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MalaCards integrated aliases for Autoimmune Disease:

Name: Autoimmune Disease 58 12 30 17
Autoimmune Diseases 56 44 74
Autoimmune Hypersensitivity Disease 12 15
Hypersensitivity Reaction Type Ii Disease 12
Type Ii Hypersensitivity Reaction Disease 17
Autoimmune Disorder 15

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant gene epistatic to other secondary genes conferring specificity to the autoimmune phenotype


Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:417
OMIM 58 109100
ICD9CM 36 720
MedGen 43 C0004364
Sources

Summaries for Autoimmune Disease

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MedlinePlus : 44 Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body. No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases. There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards based summary : Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and autoimmune disease of endocrine system. An important gene associated with Autoimmune Disease is GAS5 (Growth Arrest Specific 5), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Ledipasvir and Sofosbuvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and bone, and related phenotypes are autoimmune antibody positivity and hematopoietic system

Disease Ontology : 12 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.

Wikipedia : 77 An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.... more...

Description from OMIM: 109100
Sources

Related Diseases for Autoimmune Disease

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Diseases related to Autoimmune Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 782)
# Related Disease Score Top Affiliating Genes
1 vitiligo-associated multiple autoimmune disease susceptibility 1 34.8 AIRE CTLA4 NLRP1 PTPN22
2 autoimmune disease of endocrine system 34.1 AIRE CTLA4 IFNG PTPN22
3 autoimmune disease of eyes, ear, nose and throat 34.0 IL10 IL17A TNF
4 autoimmune disease of musculoskeletal system 34.0 APOH IL10 IL17A PTPN22 TNF TNFSF13B
5 autoimmune disease of central nervous system 34.0 IFNG IL10 IL17A MBP TNF
6 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 33.6 AIRE CTLA4 IFNG IL10 IL17A PTPN22
7 lupus erythematosus 33.0 APOH CTLA4 IL10 NLRP1 PTPN22 TNF
8 hashimoto thyroiditis 33.0 AIRE CTLA4 IFNG PTPN22
9 rheumatoid arthritis 32.9 CTLA4 IFNG IL10 IL17A NLRP1 PTPN22
10 multiple sclerosis 32.9 CTLA4 IFNG IL10 IL17A MBP TNF
11 neuromyelitis optica 32.9 IL17A MBP TNFSF13B
12 systemic lupus erythematosus 32.9 APOH CTLA4 IFNG IL10 IL17A NLRP1
13 mixed connective tissue disease 32.8 APOH IFNG IL10 TNF
14 alopecia areata 32.7 AIRE CTLA4 IFNG PTPN22 TNF
15 myasthenia gravis 32.7 AIRE CTLA4 IFNG IL10 MBP TNF
16 autoimmune pancreatitis 32.6 CTLA4 ENO1 IL10 TNFSF13B
17 diabetes mellitus, insulin-dependent 32.6 AIRE CTLA4 IFNG IL10 PTPN22
18 autoimmune uveitis 32.6 IFNG IL10 IL17A TNF
19 vogt-koyanagi-harada disease 32.6 IL10 IL17A NLRP1 PTPN22
20 behcet syndrome 32.5 APOH CTLA4 ENO1 IFNG IL10 IL17A
21 autoimmune myocarditis 32.5 IFNG TNF
22 autoimmune addison disease 32.1 AIRE CTLA4 NLRP1
23 punctate inner choroidopathy 32.1 IL10 TNF
24 reactive arthritis 32.1 IFNG IL10 IL17A TNF
25 melioidosis 32.1 IFNG IL10 TNF
26 autoimmune retinopathy 32.1 AIRE ENO1
27 interstitial lung disease 32.0 IFNG IL10 TNF
28 autoimmune optic neuritis 32.0 IL10 IL17A MBP
29 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 32.0 AIRE IFNG IL10
30 autoimmune atherosclerosis 32.0 APOH IL10
31 immune system disease 32.0 APOH IFNG IL10 IL17A MBP TNF
32 arthritis 31.8 IFNG IL10 IL17A NLRP1 PTPN22 TNF
33 hematopoietic stem cell transplantation 31.7 CTLA4 IFNG IL10 TNF
34 vasculitis 31.4 APOH TNF TNFSF13B
35 uveitis 31.1 CTLA4 IFNG IL10 IL17A TNF
36 colitis 31.1 CTLA4 IFNG IL10 IL17A TNF
37 connective tissue disease 31.0 APOH IFNG IL10 TNF TNFSF13B
38 ulcerative colitis 30.9 IFNG IL10 IL17A TNF
39 dermatitis, atopic 30.8 IFNG IL10 IL17A TNF
40 graft-versus-host disease 30.8 IFNG IL10 TNF
41 neuritis 30.8 IFNG MBP TNF
42 chronic graft versus host disease 30.8 IFNG IL10 TNF TNFSF13B
43 rheumatic disease 30.7 APOH IFNG IL10 TNF
44 common variable immunodeficiency 30.7 CTLA4 IFNG IL10 TNF TNFSF13B
45 candidiasis 30.7 AIRE IFNG IL10 IL17A
46 bacterial infectious disease 30.7 IFNG IL10 IL17A TNF
47 inflammatory bowel disease 30.6 GAS5 IFNG IL10 IL17A STAT3 TNF
48 periodontitis 30.5 IFNG IL10 IL17A TNF
49 brucellosis 30.5 IFNG IL10 TNF
50 mycobacterium tuberculosis 1 30.5 IFNG IL10 IL17A TNF

Graphical network of the top 20 diseases related to Autoimmune Disease:



Diseases related to Autoimmune Disease
Sources

Symptoms & Phenotypes for Autoimmune Disease

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Human phenotypes related to Autoimmune Disease:

33
# Description HPO Frequency HPO Source Accession
1 autoimmune antibody positivity 33 HP:0030057

Symptoms via clinical synopsis from OMIM:

58
Immunology:
autoimmune disease

Lab:
high titer autoantibody

Clinical features from OMIM:

109100

MGI Mouse Phenotypes related to Autoimmune Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 AIRE CTLA4 IFNG IL10 IL17A ITCH
2 homeostasis/metabolism MP:0005376 10.03 AIRE APOH CTLA4 IFNG IL10 IL17A
3 digestive/alimentary MP:0005381 9.97 AIRE CTLA4 IFNG IL10 IL17A PTPN22
4 immune system MP:0005387 9.97 AIRE CTLA4 IFNG IL10 IL17A ITCH
5 liver/biliary system MP:0005370 9.5 AIRE CTLA4 IFNG IL10 PTPN22 STAT3
6 respiratory system MP:0005388 9.28 AIRE CTLA4 IFNG IL10 IL17A ITCH
Sources

Drugs & Therapeutics for Autoimmune Disease

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Drugs for Autoimmune Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1246)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ledipasvir Approved Phase 4 1256388-51-8 67505836
2
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
3
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 79902-63-9 54454
4
Azithromycin Approved Phase 4,Phase 2,Phase 1 83905-01-5 55185 447043
5
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
6
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7782-49-2
7
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6 32051
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
9
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
10
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
11
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
13
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
14
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24280-93-1 446541
15
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
16
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 116094-23-6 16132418
17
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
18
Enalapril Approved, Vet_approved Phase 4,Phase 2,Not Applicable 75847-73-3 5362032 40466924
19
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
20
Enalaprilat Approved Phase 4,Phase 2,Not Applicable 76420-72-9 6917719
21
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
22
Glucagon Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 16941-32-5
23
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53608-75-6
24
Losartan Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 114798-26-4 3961
25
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
26
Insulin glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
27
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
28
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492 6473866
29
Glyburide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10238-21-8 3488
30
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
31
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
32
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 189261-10-7
33
4-Aminopyridine Approved Phase 4,Phase 3,Phase 2,Not Applicable 504-24-5 1727
34
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 65271-80-9 4212
35
Interferon beta-1b Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 145155-23-3
36
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 141758-74-9 15991534
37
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
38
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
39
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 332348-12-6 10237
40
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118-42-3 3652
41
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
42
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 599-79-1 5353980 5359476
43
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
44
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
45
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
46
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
47
Diazoxide Approved Phase 4 364-98-7 3019
48
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
49
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 15307-86-5 3033
50
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 16590-41-3 5360515

Interventional clinical trials:

(show top 50) (show all 9054)
# Name Status NCT ID Phase Drugs
1 Study to Investigate the Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With Chronic Genotype 1 and 4 HCV Infection With Autoimmune Disease Unknown status NCT02691728 Phase 4 LDV/SOF FDC
2 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
3 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
4 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
5 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
6 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
7 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
8 Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial Unknown status NCT01679561 Phase 4 intralipid
9 Probiotics in Newly Recognized Type 1 Diabetes Unknown status NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
10 Acthar for the Treatment of Systemic Lupus Erythematosus in Patients With a History of Persistently Active Disease Unknown status NCT01753401 Phase 4 Acthar;Placebo for Acthar
11 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
12 Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes (FIT) Unknown status NCT03057470 Phase 4 50% bolus insulin correction;100% bolus insulin correction;150% bolus insulin correction
13 Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy Unknown status NCT02981212 Phase 4 Mycophenolate Mofetil;ACE inhibitor;Corticosteroid;ARB
14 Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps. Unknown status NCT02685449 Phase 4 Insulin glulisine;Insulin aspart;Insulin lispro
15 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
16 The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes Unknown status NCT02307695 Phase 4 Saxagliptin;Insulin
17 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
18 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
19 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
20 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
21 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
22 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
23 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
24 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
25 Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG) Unknown status NCT00843856 Phase 4 tacrolimus;tacrolimus and mycophenolate mofetil
26 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
27 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
28 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
29 Natalizumab in Preventing Post-partum Relapses in Multiple Sclerosis Unknown status NCT03046251 Phase 4 Natalizumab
30 Methylprednisolone During the Switch Between Natalizumab and Fingolimod Unknown status NCT02769689 Phase 4 Methylprednisolone;Placebo;natalizumab (NTZ);fingolimob (FTY)
31 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
32 Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya Unknown status NCT02325440 Phase 4 Fingolimod;Natalizumab
33 Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS Unknown status NCT02259361 Phase 4 Sustained-release oral dalfampridine;Placebo
34 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
35 Impact of Vitamin A on RAR Gene Expression in Multiple Sclerosis Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
36 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
37 Impact of Vitamin A on Multiple Sclerosis (MS) Unknown status NCT01417273 Phase 4 Drug: placebo
38 Impact of Vitamin A on Gene Expression, in Multiple Sclerosis Patient Unknown status NCT01407211 Phase 4
39 Colecalciferol as an Add-on Treatment to Interferon-beta-1b for Treatment of Multiple Sclerosis (MS) Unknown status NCT01339676 Phase 4 Colecalciferol;Placebo capsules
40 Optical Coherence Tomography: Glatiramer in Clinically Isolated Syndrome or Early Relapsing Remitting Multiple Sclerosis (MS) Unknown status NCT00910598 Phase 4 glatiramer acetate
41 Phase IV Study, Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI Unknown status NCT00176592 Phase 4 Betaseron;Copaxone
42 IVIg for Demyelination in Diabetes Mellitus Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
43 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
44 Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar Gel Unknown status NCT03082573 Phase 4 H.P. Acthar gel
45 An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes Unknown status NCT02962492 Phase 4 Exenatide/Exenatide extended release;Dapagliflozin;Placebo
46 Kunxian for the Treatment of Rheumatoid Arthritis Unknown status NCT02764515 Phase 4 Kunxian Capsule;Methotrexate
47 Inhibition of Co-Stimulation in Rheumatoid Arthritis Unknown status NCT02652273 Phase 4 Abatacept
48 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
49 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
50 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4 Dapagliflozin

Search NIH Clinical Center for Autoimmune Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :
Sources

Genetic Tests for Autoimmune Disease

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Genetic tests related to Autoimmune Disease:

# Genetic test Affiliating Genes
1 Autoimmune Disease 30
Sources

Anatomical Context for Autoimmune Disease

About this section

MalaCards organs/tissues related to Autoimmune Disease:

42
T Cells, Testes, Bone, Thyroid, B Cells, Eye, Pancreas
Sources

Publications for Autoimmune Disease

About this section

Articles related to Autoimmune Disease:

(show top 50) (show all 5340)
# Title Authors Year
1
Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure. ( 30705142 )
2019
2
B Cell Dysfunction Associated With Aging and Autoimmune Diseases. ( 30873171 )
2019
3
Recurrent and universal alopecia areata following alemtuzumab treatment in multiple sclerosis: A secondary autoimmune disease. ( 30530069 )
2019
4
Experience of Biological Therapy Units in Rheumatoid Arthritis and other Autoimmune Diseases. ( 30709786 )
2019
5
Editorial: Autism Spectrum Disorder and Autoimmune Diseases: A Pathway in Common? ( 30902666 )
2019
6
Type I Interferons in Autoimmune Disease. ( 30332560 )
2019
7
Autoimmune disease-associated non-Hodgkin's lymphoma-a large retrospective study from China. ( 30370485 )
2019
8
Inflammatory Stress Causes N-Glycan Processing Deficiency in Ocular Autoimmune Disease. ( 30448401 )
2019
9
Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells. ( 30498131 )
2019
10
Pathogen infection and autoimmune disease. ( 30569518 )
2019
11
Nature of coexisting thyroid autoimmune disease determines success or failure of tumor immunity in thyroid cancer. ( 30616690 )
2019
12
The microbiome in systemic autoimmune disease: mechanistic insights from recent studies. ( 30624285 )
2019
13
Exploiting PLGA-Based Biocompatible Nanoparticles for Next-Generation Tolerogenic Vaccines against Autoimmune Disease. ( 30626016 )
2019
14
Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). ( 30663016 )
2019
15
Galactomannan testing in the treatment of autoimmune disease combined with invasive fungal disease. ( 30663298 )
2019
16
Frequency of Positive ANCA Test in a Population With Clinical Symptoms Suggestive of Autoimmune Disease and the Interference of ANA in its Interpretation. ( 30704921 )
2019
17
Autoimmune Disease-Associated Hypertension. ( 30712132 )
2019
18
Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications. ( 30728494 )
2019
19
The Differential Influence of Immunological Process of Autoimmune Disease on Lipid Metabolism: A Study on RA and SLE. ( 30728673 )
2019
20
Low HDL Cholesterol and High Risk of Autoimmune Disease: Two Population-Based Cohort Studies Including 117341 Individuals. ( 30745290 )
2019
21
Role of Exosomes in the Regulation of T-cell Mediated Immune Responses and in Autoimmune Disease. ( 30759880 )
2019
22
Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease. ( 30761150 )
2019
23
Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case-control study. ( 30779234 )
2019
24
Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy. ( 30787930 )
2019
25
Two cases of diabetes mellitus type 1 after alemtuzumab treatment for multiple sclerosis: another probable secondary autoimmune disease. ( 30805797 )
2019
26
Induced expression of Toll-like receptor 9 in peritubular capillary endothelium correlates with the progression of tubulointerstitial lesions in autoimmune disease-prone mice. ( 30813872 )
2019
27
Altered morpho-functional features of bones in autoimmune disease-prone BXSB/MpJ- Yaa mice. ( 30818998 )
2019
28
Uterine Artery Embolization in Patients With Autoimmune Disease: A Matched Case-Control Study. ( 30835520 )
2019
29
Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association. ( 30845238 )
2019
30
Pregnancy Immunogenetics and Genomics: Implications for Pregnancy-Related Complications and Autoimmune Disease. ( 30848957 )
2019
31
Lacrimal Gland Orbital Lobe Cysts Associated With Lymphoid Hyperplasia or Mucosa-Associated Lymphoid Tissue Lymphoma in Patients With Chronic Autoimmune Disease. ( 30865072 )
2019
32
Pre-existing autoimmune disease and the risk of immune-related adverse events among patients receiving checkpoint inhibitors for cancer. ( 30877325 )
2019
33
Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease. ( 30883216 )
2019
34
The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study. ( 30885252 )
2019
35
DIAGNOSIS OF ENDOCRINE DISEASE: IgG4-related thyroid autoimmune disease. ( 30889549 )
2019
36
Bacterial cell wall offcasts linked to autoimmune disease. ( 30894698 )
2019
37
Familial aggregation of myocardial infarction and coaggregation of myocardial infarction and autoimmune disease: a nationwide population-based cross-sectional study in Taiwan. ( 30898803 )
2019
38
Estimating autoantibody signatures to detect autoimmune disease patient subsets. ( 29140482 )
2019
39
The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series. ( 30639646 )
2019
40
Autoimmune diseases in myelodysplastic syndrome favors patients survival: A case control study and literature review. ( 30408583 )
2019
41
Pleuroparenchymal fibroelastosis as a histological background of autoimmune diseases. ( 30327882 )
2019
42
Prognostic factors of Pneumocystis pneumonia in patients with systemic autoimmune diseases. ( 30908547 )
2019
43
Pneumocystis jirovecii pneumonia prophylaxis in immunocompromised patients with systemic autoimmune diseases. ( 30853123 )
2019
44
Autoimmune Diseases in Systemic Sclerosis Patients and Their Relatives: Data from a Single Center. ( 30685902 )
2019
45
Evidence for an association between endometriosis, fibromyalgia and autoimmune diseases. ( 30682223 )
2019
46
Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress. ( 30687959 )
2019
47
Enhancement of cancer invasion and growth via the C5a-C5a receptor system: Implications for cancer promotion by autoimmune diseases and association with cervical cancer invasion. ( 30655847 )
2019
48
The association between infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. ( 30854088 )
2019
49
Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases. ( 30692587 )
2019
50
Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families. ( 30669308 )
2019
Sources

Variations for Autoimmune Disease

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Copy number variations for Autoimmune Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21625 1 159859611 159867782 Copy number FCGR3B Autoimmune disease
2 21792 1 161592989 161601158 Copy number FCGR3B Autoimmune disease
3 21796 1 161592989 161601158 Deletion FCGR3B Autoimmune disease
4 208909 6 211050653 211252076 Copy number CYP21B Autoimmune disease
5 210508 6 30400000 36600000 Copy number CYP21A Autoimmune disease
6 210509 6 30400000 36600000 Copy number TNXA Autoimmune disease
7 211044 6 3197570 32111174 Copy number C4A Autoimmune disease
8 211046 6 3197570 32111174 Copy number C4B Autoimmune disease
Sources

Expression for Autoimmune Disease

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Search GEO for disease gene expression data for Autoimmune Disease.
Sources

Pathways for Autoimmune Disease

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Pathways related to Autoimmune Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 38
Show member pathways
 12.77 CTLA4 IFNG IL10 IL17A TNF TNFSF13B
2
Th17 cell differentiation 38
Show member pathways
 12.48 IFNG IL10 IL17A STAT3 TNF
3
Immune response IL-23 signaling pathway 23
Show member pathways
 12.47 IFNG IL10 IL17A STAT3 TNF
4
IL-17 Family Signaling Pathways 66
Show member pathways
 12.24 IFNG IL17A STAT3 TNF
5
T cell receptor signaling pathway 38
Show member pathways
 12.21 CTLA4 IFNG IL10 IL17A TNF
6
Toxoplasmosis 38
Show member pathways
 12.17 IFNG IL10 STAT3 TNF
7
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.98 IFNG IL10 IL17A STAT3 TNFSF13B
8
Spinal Cord Injury 1
11.86 IFNG MBP TNF TNFSF13B
9
NF-kappaB Signaling 4
11.84 CTLA4 IFNG IL10 IL17A ITCH NLRP1
10
Interleukin-4 and 13 signaling 67
11.81 IL10 IL17A STAT3 TNF
11
HIF-1 signaling pathway 38
11.8 ENO1 IFNG STAT3
12
Amoebiasis 38
11.78 IFNG IL10 TNF
13
Th1 Differentiation Pathway 66
Show member pathways
 11.67 IFNG IL10 IL17A STAT3 TNF
14
Dendritic Cells Developmental Lineage Pathway 66
11.66 IFNG IL10 TNF
15
Innate Lymphoid Cell Differentiation Pathways 66
11.57 IFNG IL10 IL17A TNF
16
TGF-beta Receptor Signaling (WikiPathways) 1
11.54 IFNG STAT3 TNF
17
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.5 CTLA4 IFNG ITCH TNF
18
Interleukin-10 signaling 67
11.45 IL10 STAT3 TNF
19
Malaria 38
11.44 IFNG IL10 TNF
20
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.41 IFNG IL10 IL17A TNF
21
Rheumatoid arthritis 38
11.31 CTLA4 IFNG IL17A TNF TNFSF13B
22
African trypanosomiasis 38
11.27 IFNG IL10 TNF
23
IL-10 Pathway 65
11.23 IL10 STAT3 TNF
24
Development and heterogeneity of the ILC family 1
11.18 IFNG IL17A TNF
25
G-protein signaling_RhoB regulation pathway 23
11.12 IL10 IL17A TNF TNFSF13B
26
Cytokines and Inflammatory Response 1
11.07 IFNG IL10 TNF
Sources

GO Terms for Autoimmune Disease

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Cellular components related to Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 APOH ENO1 IFNG IL10 IL17A SIAE

Biological processes related to Autoimmune Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.89 IFNG IL10 IL17A TNF TNFSF13B
2 cytokine-mediated signaling pathway GO:0019221 9.88 IL10 IL17A STAT3 TNF
3 negative regulation of gene expression GO:0010629 9.85 IFNG PTPN22 TNF ZFAT-AS1
4 response to organic substance GO:0010033 9.73 IL10 STAT3 TNF
5 humoral immune response GO:0006959 9.63 AIRE IFNG TNF
6 negative regulation of B cell proliferation GO:0030889 9.61 CTLA4 IL10
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IFNG TNF
8 regulation of regulatory T cell differentiation GO:0045589 9.59 CTLA4 IFNG
9 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL10 TNF
11 positive regulation of ATP biosynthetic process GO:2001171 9.54 ENO1 STAT3
12 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.52 IL10 MBP
13 positive regulation of metalloendopeptidase activity GO:1904685 9.51 MBP STAT3
14 endothelial cell apoptotic process GO:0072577 9.48 IL10 TNF
15 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
16 inflammatory response GO:0006954 9.43 IL10 IL17A ITCH NLRP1 STAT3 TNF
17 positive regulation of interleukin-23 production GO:0032747 9.4 IFNG IL17A
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
19 positive regulation of osteoclast differentiation GO:0045672 9.33 IFNG IL17A TNF
20 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
22 immune response GO:0006955 9.23 AIRE CTLA4 IFNG IL10 IL17A MBP
23 immune system process GO:0002376 10.01 CTLA4 ITCH NLRP1 PTPN22 TNFSF13B

Molecular functions related to Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL10 IL17A TNF TNFSF13B
Sources

Sources for Autoimmune Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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