Aliases & Classifications for Autoimmune Disease

MalaCards integrated aliases for Autoimmune Disease:

Name: Autoimmune Disease 57 12 29 17
Autoimmune Diseases 55 43 15 72
Autoimmune Hypersensitivity Disease 12 15
Hypersensitivity Reaction Type Ii Disease 12
Type Ii Hypersensitivity Reaction Disease 17

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant gene epistatic to other secondary genes conferring specificity to the autoimmune phenotype


HPO:

32
autoimmune disease:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:417
OMIM 57 109100
ICD9CM 35 720
MedGen 42 C0004364
UMLS 72 C0003089 C0004364

Summaries for Autoimmune Disease

MedlinePlus : 43 Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body. No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases. There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

MalaCards based summary : Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and autoimmune disease of endocrine system. An important gene associated with Autoimmune Disease is GAS5 (Growth Arrest Specific 5), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Azithromycin and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and thyroid, and related phenotypes are autoimmune antibody positivity and hematopoietic system

Disease Ontology : 12 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.

Wikipedia : 75 An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.... more...

More information from OMIM: 109100

Related Diseases for Autoimmune Disease

Diseases related to Autoimmune Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1349)
# Related Disease Score Top Affiliating Genes
1 vitiligo-associated multiple autoimmune disease susceptibility 1 35.6 PTPN22 NLRP1 CTLA4 AIRE
2 autoimmune disease of endocrine system 34.9 PTPN22 IFNG CTLA4 AIRE
3 autoimmune disease of eyes, ear, nose and throat 34.8 TNF IL17A IL10
4 autoimmune disease of musculoskeletal system 34.8 TNFSF13B TNF PTPN22 IL17A IL10 APOH
5 autoimmune disease of central nervous system 34.7 TNF MBP IL17A IL10 IFNG
6 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 34.1 TNFSF13B PTPN22 IL17A IL10 IFNG CTLA4
7 hashimoto thyroiditis 34.0 PTPN22 IFNG CTLA4 AIRE
8 systemic lupus erythematosus 34.0 TNFSF13B TNF PTPN22 NLRP1 IL17A IL10
9 mixed connective tissue disease 33.9 TNF IL10 IFNG APOH
10 lupus erythematosus 33.8 TNF PTPN22 NLRP1 IL10 CTLA4 APOH
11 rheumatoid arthritis 33.8 TNFSF13B TNF PTPN22 NLRP1 IL17A IL10
12 myasthenia gravis 33.8 TNFSF13B TNF MBP IL10 IFNG CTLA4
13 neuromyelitis optica 33.7 TNFSF13B MBP IL17A
14 vogt-koyanagi-harada disease 33.7 PTPN22 NLRP1 IL17A IL10
15 alopecia areata 33.7 TNF PTPN22 IFNG CTLA4 AIRE
16 multiple sclerosis 33.6 TNFSF13B TNF MBP IL17A IL10 IFNG
17 diabetes mellitus, insulin-dependent 33.6 PTPN22 IL10 IFNG CTLA4 AIRE
18 autoimmune pancreatitis 33.5 TNFSF13B IL10 ENO1 CTLA4
19 autoimmune uveitis 33.5 TNF IL17A IL10 IFNG
20 reactive arthritis 33.5 TNF IL17A IL10 IFNG
21 behcet syndrome 33.4 TNF IL17A IL10 IFNG ENO1 CTLA4
22 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 33.3 IL10 IFNG AIRE
23 interstitial lung disease 33.3 TNF IL10 IFNG
24 autoimmune myocarditis 33.2 TNF IFNG
25 autoimmune atherosclerosis 33.2 IL10 APOH
26 punctate inner choroidopathy 33.0 TNF IL10
27 melioidosis 32.9 TNF IL10 IFNG
28 autoimmune retinopathy 32.9 ENO1 AIRE
29 autoimmune optic neuritis 32.8 MBP IL17A IL10
30 vasculitis 32.8 TNFSF13B TNF APOH
31 immune system disease 32.8 TNFSF13B TNF MBP IL17A IL10 IFNG
32 connective tissue disease 32.6 TNFSF13B TNF IL10 IFNG APOH
33 hematopoietic stem cell transplantation 32.5 TNF IL10 IFNG CTLA4
34 uveitis 32.5 TNF IL17A IL10 IFNG CTLA4
35 ulcerative colitis 32.3 TNF IL17A IL10 IFNG
36 rheumatic disease 32.1 TNF IL10 IFNG APOH
37 graft-versus-host disease 32.1 TNF IL10 IFNG
38 temporal arteritis 32.1 TNF PTPN22 IFNG APOH
39 arthritis 32.1 TNF PTPN22 NLRP1 IL17A IL10 IFNG
40 candidiasis 32.0 IL17A IL10 IFNG AIRE
41 dermatitis, atopic 32.0 TNF IL17A IL10 IFNG
42 chronic graft versus host disease 31.9 TNFSF13B TNF IL10 IFNG
43 skin disease 31.9 TNF IL17A IL10 IFNG
44 neuritis 31.9 TNF MBP IFNG
45 demyelinating disease 31.9 TNF MBP IL17A IL10 IFNG
46 bacterial infectious disease 31.9 TNF IL17A IL10 IFNG
47 inflammatory bowel disease 31.9 TNF STAT3 IL17A IL10 IFNG GAS5
48 proteasome-associated autoinflammatory syndrome 1 31.8 TNF IL17A IL10 IFNG
49 hypoadrenocorticism, familial 31.8 PTPN22 CTLA4 AIRE
50 common variable immunodeficiency 31.8 TNFSF13B TNF IL10 IFNG CTLA4

Graphical network of the top 20 diseases related to Autoimmune Disease:



Diseases related to Autoimmune Disease

Symptoms & Phenotypes for Autoimmune Disease

Human phenotypes related to Autoimmune Disease:

32
# Description HPO Frequency HPO Source Accession
1 autoimmune antibody positivity 32 HP:0030057

Symptoms via clinical synopsis from OMIM:

57
Immunology:
autoimmune disease

Lab:
high titer autoantibody

Clinical features from OMIM:

109100

MGI Mouse Phenotypes related to Autoimmune Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 AIRE CTLA4 IFNG IL10 IL17A ITCH
2 homeostasis/metabolism MP:0005376 10.03 AIRE APOH CTLA4 IFNG IL10 IL17A
3 digestive/alimentary MP:0005381 9.97 AIRE CTLA4 IFNG IL10 IL17A PTPN22
4 immune system MP:0005387 9.97 AIRE CTLA4 IFNG IL10 IL17A ITCH
5 liver/biliary system MP:0005370 9.5 AIRE CTLA4 IFNG IL10 PTPN22 STAT3
6 respiratory system MP:0005388 9.28 AIRE CTLA4 IFNG IL10 IL17A ITCH

Drugs & Therapeutics for Autoimmune Disease

Drugs for Autoimmune Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 643)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043 55185
2
Mycophenolic acid Approved Phase 4 24280-93-1 446541
3
Sirolimus Approved, Investigational Phase 4 53123-88-9 6436030 5284616 46835353
4
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 23925 27284
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
8
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
9
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
10
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
11
Insulin glargine Approved Phase 4 160337-95-1
12
Insulin Aspart Approved Phase 4 116094-23-6 16132418
13
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
14
Halofantrine Approved Phase 4 69756-53-2 37393
15 Orange Approved Phase 4
16 Strawberry Approved Phase 4
17 Artichoke Approved Phase 4
18
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
19
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
20
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
21
Etanercept Approved, Investigational Phase 4 185243-69-0
22
Abatacept Approved Phase 4 332348-12-6 10237
23
Hydroxychloroquine Approved Phase 4 118-42-3 3652
24
Tofacitinib Approved, Investigational Phase 4 477600-75-2
25
Artesunate Approved, Investigational Phase 4 88495-63-0 5464098 6917864
26
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
27
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
28
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
29
belimumab Approved Phase 4 356547-88-1 5957 10451420
30
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
31
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
32
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
33
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
34
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
35
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
36
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
37
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
38
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
39
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
40
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
41
Adefovir Investigational Phase 4 106941-25-7
42 Tocotrienol Investigational Phase 4 6829-55-6
43 Rosuvastatin Calcium Phase 4 147098-20-2
44 Anti-Bacterial Agents Phase 4
45 Antitubercular Agents Phase 4
46 Antibiotics, Antitubercular Phase 4
47 Thymoglobulin Phase 4
48 Antineoplastic Agents, Phytogenic Phase 4
49 Antilymphocyte Serum Phase 4
50 Protective Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 1327)
# Name Status NCT ID Phase Drugs
1 A Phase 4, Open-Label Study to Investigate the Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With Chronic Genotype 1 and 4 HCV Infection With Autoimmune Disease Unknown status NCT02691728 Phase 4 LDV/SOF FDC
2 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in SLE Patients With Corticosteroid Therapy and High LDL Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
3 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
4 A Phase IV, Single-site, Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
5 Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels Unknown status NCT01115842 Phase 4 Vitamin D
6 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
7 Endothelial Dysfunction in Systemic Lupus Erythematosus: Its Contribution to Abnormalities in Coronary Perfusion. Unknown status NCT00188188 Phase 4 quinipril
8 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
9 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Completed NCT00815282 Phase 4
10 A Placebo Controlled Trial of Amoxicillin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4 Amoxicillin
11 Evaluation of Vaccination Against Influenza (Seasonal and H1N1) in Patients Presenting Systemic or Autoimmune Diseases Treated or Not With Steroids, and/or Immunosuppressant, and/or Biotherapy: an Open, Prospective Trial (MAIVAX) Completed NCT01065285 Phase 4
12 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
13 Study Evaluating Rapid Infusion Rituximab in Patients With Autoimmune Diseases Completed NCT02040116 Phase 4 Rituximab Infusion
14 A Randomized Comparative Study of Efficacy and Safety of Topical Latanoprost Versus Topical Corticosteroid in the Treatment of Localized Alopecia Areata Completed NCT02350023 Phase 4 Topical latanoprost 0.005%;Topical betamethasone 0.05%
15 Open Label Study of Hydroxychloroquine for Alopecia Areata, Alopecia Totalis Completed NCT00176982 Phase 4 Hydroxychloroquine
16 Influence of Plasma Exchange Therapy on the Pharmacokinetics of Rituximab in Patients Treated for Autoimmune Disorders. Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
17 A Phase 4, Multi-Center, Randomized, Open-Label Study to Evaluate the Effect of BENLYSTA™ (Belimumab; HGS1006) on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE) Completed NCT01597492 Phase 4
18 Prospective, Randomized, Double Blind Placebo Controled Clinical Trial to Assess the Multi- Systemic Effect of Vitamin D Supplementation on Young Men With Vitamin D Deficiency Completed NCT01016184 Phase 4
19 Placebo Controlled Pilot Study on Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes on Immunological, Endocrine and Metabolic Parameters: Step 2 in the Austrian Diabetes Prevention Programme Completed NCT01390480 Phase 4 Cholecalciferol
20 A Phase 3/4, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006) in Adult Subjects of Black Race With Systemic Lupus Erythematosus (SLE) Completed NCT01632241 Phase 4 Standard therapy
21 Placebo Controlled Study to Assess the Effects of Vitamin D Supplementation on Parameters of the Immune, Endocrine and Metabolic System in Healthy Women and Men. Completed NCT01248442 Phase 4 Cholecalciferol;Placebo
22 Effect Of Hormone Replacement Therapy On Disease Activity, Menopausal Symptoms And Bone Mineral Density In Peri/Postmenopausal Women With Systemic Lupus Erythematosus.Randomized Clinical Trial Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
23 Multicenter Randomized Clinical Trial in Patients With Juvenile Idiopathic Arthritis: Safety and Efficacy of Vaccination With Live Attenuated Measles, Mumps, Rubella Vaccine Completed NCT00731965 Phase 4
24 Use of Vitamin D in Treatment of Non-Alcoholic Fatty Liver Disease Detected by Transient Elastography Completed NCT04038853 Phase 4 1,25-Dihydroxyvitamin D;Placebo
25 The Effect of Insulin Degludec on Risk of Symptomatic Nocturnal Hypoglycaemia in Subjects With Type 1 Diabetes and High Risk of Nocturnal Severe Hypoglycaemia Completed NCT02192450 Phase 4 Insulin aspart/glargine;Insulin aspart/degludec
26 Effect of Ergocalciferol Repletion on Urine Calcium Among Stone Formers With Vitamin D Deficiency and Hypercalciuria Completed NCT01295879 Phase 4 Ergocalciferol
27 Pneumococcal Vaccination of Crohn Patients - A Randomized, Non-blinded Phase 4 Clinical Trial With the Purpose of Investigating the Immune Response Against Two Different Pneumococcal Vaccines in Patients With Crohn's Disease Completed NCT01947010 Phase 4
28 Comparison of Two Standard High-dose Treatment Regimens for Vitamin D Deficiency in Minority Adolescents: Associations of Vitamin D Repletion With Changes in Markers of Musculoskeletal, Cardiometabolic, and Immune Function Completed NCT01784029 Phase 4 Vitamin D3
29 A Phase IV, Open Label Study Introducing a Single IV Treatment With Abatacept in Patients With Rheumatoid Arthritis Currently Receiving Weekly Injections of SC Abatacept to Simulate a Holiday or Patient Vacation Completed NCT01846975 Phase 4 IV Abatacept
30 A Multi-Center, Pre-Marketing Clinical Trial to Evaluate the Efficacy and Safety of Infliximab Treatment on Rheumatoid Arthritis Completed NCT00896168 Phase 4 Infliximab;Methotrexate
31 Comparison Between Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
32 EFFECTS OF A DIET RICH IN N-3 POLYUNSATURATED FATTY ACIDS ON SYSTEMIC INFLAMMATION IN RENAL TRANSPLANT RECIPIENTS Completed NCT01872455 Phase 4
33 SWITCH OR ADD PEGYLATED-INTERFERON IN CHRONIC HEPATITIS B PATIENTS ON LONG TERM NUCLEOS(T)IDE THERAPY (SWAP TRIAL) Completed NCT01928511 Phase 4 peg-interferon alpha 2b, 1.5mcg/kg s/c given weekly;Nucleos(t)ide analogue therapy
34 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
35 Everolimus in Association With Very Low-dose Tacrolimus Versus Enteric-coated Mycophenolate Sodium With Low-dose Tacrolimus in de Novo Renal Transplant Recipients - A Prospective Single Center Study Completed NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
36 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
37 Metabolic and Vascular Effects of Silybin in Hypertensive Patients With High One-hour Post-load Plasma Glucose: a Single Arm Pilot Study Completed NCT03538327 Phase 4 Silybin
38 Alemtuzumab in Autoimmune Inflammatory Neurodegeneration: Mechanisms of Action and Neuroprotective Potential Recruiting NCT02419378 Phase 4 Alemtuzumab
39 Relevance of Monitoring Blood Levels Compared to Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases: Adherence and Understanding the Possible Underlying Mechanisms Involved in Effectiveness and in Adverse Effects Recruiting NCT03122431 Phase 4 Thalidomide;Hydroxychloroquine reduced;Hydroxychloroquine high
40 MIRACLE (Methotrexate Inadequate Response Patient With Rheumatoid Arthritis Treated by Adalimumab in Combination With Low-dose Methotrexate) Study Recruiting NCT03505008 Phase 4 Methotrexate;Adalimumab
41 Tacrolimus Treatment for Refractory Pure Red Cell Aplasia, a Prospective Study Recruiting NCT03540472 Phase 4 tacrolimus
42 Sirolimus Treatment for Refractory Pure Red Cell Aplasia, a Prospective Study Recruiting NCT03364764 Phase 4 Sirolimus
43 A Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Artesunate Plus Standard of Care in Active Lupus Nephritis: Pilot Study Recruiting NCT03214731 Phase 4 Artesunate
44 Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy:a Single Center Prospective Randomized Controlled Study Recruiting NCT02765594 Phase 4 Hydroxychloroquine Sulfate;Valsartan
45 Open-label Prospective Randomized Study to Determine the Efficacy and Safety of Two Dosing Regimens of ACTHar in the Treatment of Proliferative Lupus Nephritis. Recruiting NCT02226341 Phase 4 CellCept;ACTHar gel;ACTHar gel
46 Immunoadsorption in Anti-glomerular Basement Membrane Glomerulonephritis; a Pilot Study Recruiting NCT02765789 Phase 4
47 Effectiveness and Safety of Tofacitinib in Patients With Extensive and Recalcitrant Alopecia Areata Recruiting NCT03800979 Phase 4 Tofacitinib
48 Phase IV Study of Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
49 Abatacept for the Treatment of Refractory Juvenile Dermatomyositis Recruiting NCT02594735 Phase 4 Abatacept
50 Stopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid Arthritis (STARA) Clinical Trial Recruiting NCT01793519 Phase 4 Etanercept;Infliximab;Adalimumab;Placebo

Search NIH Clinical Center for Autoimmune Disease

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Methylprednisolone
methylprednisolone acetate
Methylprednisolone Sodium Succinate
Prednisone
PREDNISONE PWDR

Genetic Tests for Autoimmune Disease

Genetic tests related to Autoimmune Disease:

# Genetic test Affiliating Genes
1 Autoimmune Disease 29

Anatomical Context for Autoimmune Disease

MalaCards organs/tissues related to Autoimmune Disease:

41
T Cells, B Cells, Thyroid, Bone, Liver, Skin, Neutrophil

Publications for Autoimmune Disease

Articles related to Autoimmune Disease:

(show top 50) (show all 52915)
# Title Authors PMID Year
1
Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. 38 8
9707586 1998
2
Familial polyarteritis nodosa: a serologic and immunogenetic analysis. 38 8
2568486 1989
3
Classification of experimental data for genetic analysis in autoimmune disease. 38 8
3337106 1988
4
Evidence that autoimmunity in man is a Mendelian dominant trait. 38 8
3098096 1986
5
Primary Sjögren's syndrome and other autoimmune diseases in families. Prevalence and immunogenetic studies in six kindreds. 38 8
6437309 1984
6
Genetic factors predisposing to autoimmune diseases. Autoimmune hemolytic anemia, chronic thrombocytopenic purpura, and systemic lupus erythematosus. 38 8
6756137 1982
7
H gene theory of inherited autoimmune disease. 38 8
6101848 1980
8
Interleukin-17: Functional and Structural Features, Application as a Therapeutic Target. 38 17
31213202 2019
9
The role of interleukins and their inhibitors in the development of autoimmune uveitis. 38 17
31055563 2019
10
Pediatric and adult forms of type I autoimmune hepatitis in Argentina: evidence for differential genetic predisposition. 8
10573514 1999
11
Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions. 8
10599734 1999
12
Familial polyarteritis nodosa. 8
7914412 1994
13
On genetic components in autoimmunity: a critical review based on evolutionarily oriented rationality. 8
1483686 1992
14
Evidence that autoimmunity in man is a Mendelian dominant trait. 8
3337107 1988
15
Inherited susceptibility to autoimmune Addison's disease is linked to human leukocyte antigens-DR3 and/or DR4, except when associated with type I autoimmune polyglandular syndrome. 8
3484749 1986
16
[Familial autoimmune pathology comprising 2 cases of primary biliary cirrhosis]. 8
6578990 1983
17
Hereditary autoimmune thrombocytopenic purpura: an immunologic and genetic study. 8
7195175 1981
18
The genetic lesions of autoimmunity. 8
6769621 1980
19
Hereditary aspects of autoimmune hemolytic anemia; a retrospective analysis. 8
5660845 1968
20
MYASTHENIA GRAVIS AND HYPERTHYROIDISM IN TWO SISTERS. 8
14158527 1964
21
PANDAS: What nurses need to know. 17
31343533 2019
22
A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity. 9 38
20417303 2010
23
Functional signaling of membrane-bound TL1A induces IFN-gamma expression. 9 38
20403353 2010
24
Retinoic acid-inducible gene-I (RIG-I) is induced by IFN-{gamma} in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis. 9 38
20167631 2010
25
IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity. 9 38
20020328 2010
26
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design. 9 38
20459090 2010
27
Allele and haplotype frequency distribution in PTPN22 gene across variable ethnic groups: Implications for genetic association studies for autoimmune diseases. 9 38
20166877 2010
28
The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease. 9 38
20383174 2010
29
Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. 9 38
20434372 2010
30
ST2: a novel biomarker for heart failure. 9 38
20465500 2010
31
The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population. 9 38
20138855 2010
32
The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. 9 38
20412057 2010
33
HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease. 9 38
20300120 2010
34
Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. 9 38
20478055 2010
35
Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap. 9 38
20479942 2010
36
Interleukin-17 and its expanding biological functions. 9 38
20383173 2010
37
STAT4 gene influences genetic predisposition to ulcerative colitis but not Crohn's disease in the Spanish population: a replication study. 9 38
20153791 2010
38
Expression of IFNalpha-inducible genes and modulation of HLA-DR and thyroid stimulating hormone receptors in Graves' disease. 9 38
20015465 2010
39
American Chemical Society-239th national meeting--Investigating new therapeutic candidates: part 2. 21-25 March 2010, San Francisco, CA, USA. 9 38
20432181 2010
40
High levels of B cell activating factor during the peritransplantation period are associated with a reduced incidence of acute graft-versus-host disease following myeloablative allogeneic stem cell transplantation. 9 38
19963070 2010
41
Novel sequence variation of AIRE and detection of interferon-omega antibodies in early infancy. 9 38
19863576 2010
42
Critical appraisal of tocilizumab in the treatment of moderate to severe rheumatoid arthritis. 9 38
20421913 2010
43
Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred mice. 9 38
20407472 2010
44
Type I interferon therapy and its role in autoimmunity. 9 38
20298125 2010
45
The interferon-inducible HIN-200 gene family in apoptosis and inflammation: implication for autoimmunity. 9 38
20187706 2010
46
Immune responses to Epstein-Barr virus in individuals with systemic and organ specific autoimmune disorders. 9 38
20404456 2010
47
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. 9 38
20454450 2010
48
Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease. 9 38
20176035 2010
49
Potential role of interleukin-17 in the pathogenesis of bullous pemphigoid. 9 38
19945799 2010
50
Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation. 9 38
20154336 2010

Variations for Autoimmune Disease

Copy number variations for Autoimmune Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 208909 6 211050653 211252076 Copy number CYP21B Autoimmune disease
2 211044 6 3197570 32111174 Copy number C4A Autoimmune disease
3 211046 6 3197570 32111174 Copy number C4B Autoimmune disease
4 210509 6 30400000 36600000 Copy number TNXA Autoimmune disease
5 210508 6 30400000 36600000 Copy number CYP21A Autoimmune disease
6 21796 1 161592989 161601158 Deletion FCGR3B Autoimmune disease
7 21792 1 161592989 161601158 Copy number FCGR3B Autoimmune disease
8 21625 1 159859611 159867782 Copy number FCGR3B Autoimmune disease

Expression for Autoimmune Disease

Search GEO for disease gene expression data for Autoimmune Disease.

Pathways for Autoimmune Disease

Pathways related to Autoimmune Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 TNFSF13B TNF IL17A IL10 IFNG CTLA4
2
Show member pathways
12.48 TNF STAT3 IL17A IL10 IFNG
3
Show member pathways
12.47 TNF STAT3 IL17A IL10 IFNG
4
Show member pathways
12.34 TNF IL17A IL10 IFNG CTLA4
5
Show member pathways
12.24 TNF STAT3 IL17A IFNG
6
Show member pathways
12.17 TNF STAT3 IL10 IFNG
7
Show member pathways
11.98 TNFSF13B STAT3 IL17A IL10 IFNG
8 11.86 TNFSF13B TNF MBP IFNG
9 11.84 STAT3 IFNG ENO1
10 11.84 TNFSF13B TNF STAT3 PTPN22 NLRP1 ITCH
11 11.81 TNF IL10 IFNG
12 11.81 TNF STAT3 IL17A IL10
13
Show member pathways
11.67 TNF STAT3 IL17A IL10 IFNG
14 11.66 TNF IL10 IFNG
15 11.57 TNF IL17A IL10 IFNG
16 11.54 TNF STAT3 IFNG
17
Show member pathways
11.5 TNF ITCH IFNG CTLA4
18 11.45 TNF IL10 IFNG
19 11.44 TNF STAT3 IL10
20 11.41 TNF IL17A IL10 IFNG
21 11.32 TNFSF13B TNF IL17A IFNG CTLA4
22 11.25 TNF IL10 IFNG
23 11.24 TNF STAT3 IL10
24 11.18 TNF IL17A IFNG
25 11.12 TNFSF13B TNF IL17A IL10
26 11.07 TNF IL10 IFNG

GO Terms for Autoimmune Disease

Cellular components related to Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNFSF13B TNF SIAE IL17A IL10 IFNG

Biological processes related to Autoimmune Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 TNF STAT3 IL17A IL10
2 negative regulation of gene expression GO:0010629 9.84 ZFAT-AS1 TNF PTPN22 IFNG
3 response to organic substance GO:0010033 9.72 TNF STAT3 IL10
4 humoral immune response GO:0006959 9.63 TNF IFNG AIRE
5 regulation of regulatory T cell differentiation GO:0045589 9.6 IFNG CTLA4
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 TNF IFNG
7 negative regulation of B cell proliferation GO:0030889 9.58 IL10 CTLA4
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 TNF IL10
9 negative regulation of growth of symbiont in host GO:0044130 9.56 TNF IL10
10 positive regulation of ATP biosynthetic process GO:2001171 9.52 STAT3 ENO1
11 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.51 MBP IL10
12 positive regulation of metalloendopeptidase activity GO:1904685 9.49 STAT3 MBP
13 endothelial cell apoptotic process GO:0072577 9.48 TNF IL10
14 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 TNF IL10
15 inflammatory response GO:0006954 9.43 TNF STAT3 NLRP1 ITCH IL17A IL10
16 positive regulation of interleukin-23 production GO:0032747 9.4 IL17A IFNG
17 receptor biosynthetic process GO:0032800 9.37 TNF IL10
18 positive regulation of osteoclast differentiation GO:0045672 9.33 TNF IL17A IFNG
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IFNG
20 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 TNF IFNG
21 immune response GO:0006955 9.23 TNFSF13B TNF MBP IL17A IL10 IFNG
22 immune system process GO:0002376 10 TNFSF13B PTPN22 NLRP1 ITCH CTLA4

Molecular functions related to Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNFSF13B TNF IL17A IL10 IFNG

Sources for Autoimmune Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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