AIS2
MCID: ATM053
MIFTS: 16

Autoimmune Disease 2 (AIS2)

Aliases & Classifications for Autoimmune Disease 2

MalaCards integrated aliases for Autoimmune Disease 2:

Name: Autoimmune Disease 2 57
Autoimmune Disease, Susceptibility to, 2 57 13
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 3; Vamas3 57
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 3 57
Autoimmune Disease Susceptibility Locus, Chromosome 7-Related 57
Vamas3 57
Ais2 57

External Ids:

OMIM® 57 608391

Summaries for Autoimmune Disease 2

MalaCards based summary : Autoimmune Disease 2, also known as autoimmune disease, susceptibility to, 2, is related to vitiligo-associated multiple autoimmune disease susceptibility 6 and vitiligo-associated multiple autoimmune disease susceptibility 1. An important gene associated with Autoimmune Disease 2 is AIS2 (Autoimmune Susceptibility 2). The drugs Immunoglobulins and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include thyroid and kidney.

More information from OMIM: 608391

Related Diseases for Autoimmune Disease 2

Diseases related to Autoimmune Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
2 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
3 autoimmune disease 3 9.9
4 autoimmune disease 9.8
5 rheumatoid arthritis 9.8

Graphical network of the top 20 diseases related to Autoimmune Disease 2:



Diseases related to Autoimmune Disease 2

Symptoms & Phenotypes for Autoimmune Disease 2

Clinical features from OMIM®:

608391 (Updated 05-Apr-2021)

Drugs & Therapeutics for Autoimmune Disease 2

Drugs for Autoimmune Disease 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 1
2 Pharmaceutical Solutions Phase 1
3 Immunologic Factors Phase 1
4 Antibodies Phase 1
5 Immunoglobulins, Intravenous Phase 1
6 Rho(D) Immune Globulin Phase 1
7 gamma-Globulins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label Trial of Intravenous Immune Globulin (IVIG)in Treating Spinocerebellar Ataxias Unknown status NCT02287064 Phase 1 Intravenous Immune Globulin (IVIG)

Search NIH Clinical Center for Autoimmune Disease 2

Genetic Tests for Autoimmune Disease 2

Anatomical Context for Autoimmune Disease 2

MalaCards organs/tissues related to Autoimmune Disease 2:

40
Thyroid, Kidney

Publications for Autoimmune Disease 2

Articles related to Autoimmune Disease 2:

(show all 15)
# Title Authors PMID Year
1
Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis. 57
14691733 2004
2
Mapping of an autoimmunity susceptibility locus (AIS1) to chromosome 1p31.3-p32.2. 57
11912181 2002
3
Association of Maternal Autoimmune Disease With Attention-Deficit/Hyperactivity Disorder in Children. 61
33464287 2021
4
Etiologies and management of haemophagocytic lymphohistiocytosis: is it time for an updated protocol and targeted treatments? 61
33313881 2020
5
Major Bleeding and Risk of Death after Percutaneous Native Kidney Biopsies: A French Nationwide Cohort Study. 61
33060158 2020
6
A Potential Therapeutic Target RNA-binding Protein, Arid5a for the Treatment of Inflammatory Disease Associated with Aberrant Cytokine Expression. 61
29701145 2018
7
Tear Matrix Metalloproteinases and Myeloperoxidase Levels in Patients With Boston Keratoprosthesis Type I. 61
27191670 2016
8
Retrospective analysis of 15 cases of Penicilliosis marneffei in a southern China hospital. 61
24715630 2014
9
Causes of Persistently Elevated Alanine Aminotransferase Levels in Patients who Presented to Two Referral Hospitals in Mashhad, Iran during 2011. 61
24829700 2014
10
[II. Autoimmune disease: 2. Renal disturbance in rheumatoid arthritis]. 61
21702139 2011
11
Orderly pattern of development of the autoantibody response in (New Zealand White x BXSB)F1 lupus mice: characterization of target antigens and antigen spreading by two-dimensional gel electrophoresis and mass spectrometry. 61
12244208 2002
12
DNA vaccines: safety and efficacy issues. 61
9406350 1997
13
Lupus erythematosus in the 1980s: a survey of 570 patients. 61
1948102 1991
14
[Thyroid disease in progressive systemic sclerosis]. 61
2133148 1990
15
[Genetic factors predisposing to autoimmune diseases. Study of HLA antigens in a family with pernicious anemia and thyroid diseases]. 61
3433088 1987

Variations for Autoimmune Disease 2

Expression for Autoimmune Disease 2

Search GEO for disease gene expression data for Autoimmune Disease 2.

Pathways for Autoimmune Disease 2

GO Terms for Autoimmune Disease 2

Sources for Autoimmune Disease 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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