MCID: ATM012
MIFTS: 28

Autoimmune Disease of Blood

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Blood

MalaCards integrated aliases for Autoimmune Disease of Blood:

Name: Autoimmune Disease of Blood 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060050

Summaries for Autoimmune Disease of Blood

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.

MalaCards based summary : Autoimmune Disease of Blood is related to anemia, autoimmune hemolytic and autoimmune disease. An important gene associated with Autoimmune Disease of Blood is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include t cells, b cells and eye, and related phenotypes are hematopoietic system and cellular

Related Diseases for Autoimmune Disease of Blood

Diseases related to Autoimmune Disease of Blood via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 414)
# Related Disease Score Top Affiliating Genes
1 anemia, autoimmune hemolytic 30.6 TNFSF13B RHCE ICOSLG HP FOXP3 CD8A
2 autoimmune disease 29.7 TNFSF13B IL10 ICOSLG FOXP3 CD40LG CCR6
3 riedel's fibrosing thyroiditis 10.7 CD40LG CD4
4 cryofibrinogenemia 10.7 HP CD40LG
5 thrombocytopenia 3 10.7 THPO MPL
6 malignant gastric germ cell tumor 10.6 ITGB3 ITGA2B
7 congenital hypogammaglobulinemia 10.6 CD40LG CD19
8 ventilation pneumonitis 10.6 CD8A CD4
9 diffuse infiltrative lymphocytosis syndrome 10.6 CD8A CD4
10 autoimmune lymphoproliferative syndrome, type iia 10.6 CD8A CD4
11 monoclonal paraproteinemia 10.6 CD40LG CD19
12 latent syphilis 10.6 CD40LG CD4
13 gastroduodenitis 10.6 CD40LG CD4
14 heparin-induced thrombocytopenia 10.6 F3 CD40LG
15 dyskeratosis congenita, autosomal dominant 6 10.6 THPO MPL
16 fournier gangrene 10.6 F3 CD40LG
17 autoimmune disease of peripheral nervous system 10.6 ICOSLG CD40LG CD4
18 primary syphilis 10.6 CD40LG CD4
19 cork-handlers' disease 10.6 CD8A CD40LG CD4
20 selective immunoglobulin deficiency disease 10.6 ICOSLG CD8A CD40LG
21 fetal and neonatal alloimmune thrombocytopenia 10.6 ITGB3 ITGA2B
22 syphilitic meningitis 10.6 CD8A CD40LG CD4
23 chromosome 14q11-q22 deletion syndrome 10.6 CD8A CD4
24 asymptomatic neurosyphilis 10.6 CD40LG CD4
25 diabetes mellitus, insulin-dependent, 23 10.6 CD8A CD4
26 chancroid 10.6 CD40LG CD4 CCR6
27 early yaws 10.6 CD8A CD40LG CD4
28 immune-complex glomerulonephritis 10.6 ICOSLG CD40LG CD4
29 astrakhan spotted fever 10.6 F3 CD40LG
30 scleral disease 10.6 CD40LG CD4 CCR6
31 acquired thrombocytopenia 10.6 THPO MPL ITGB3
32 vulvar angiokeratoma 10.6 HP F3
33 norwegian scabies 10.6 CD8A CD40LG CD4
34 cryoglobulinemia, familial mixed 10.6 CD5 CD40LG
35 bird fancier's lung 10.6 CD8A CD4
36 tertiary syphilis 10.6 CD8A CD40LG CD4
37 acute retinal necrosis syndrome 10.6 CD8A CD40LG CD4
38 granulomatous hepatitis 10.6 CD8A CD40LG CD4
39 iritis 10.6 CD40LG CD4 CCR6
40 vaginal discharge 10.6 HP CD40LG CD4
41 west nile encephalitis 10.6 CD8A CD40LG CD4
42 cerebritis 10.6 CD8A CD40LG CD4
43 parotid disease 10.6 CD8A CD40LG CD4
44 secondary syphilis 10.6 CD8A CD40LG CD4
45 tularemia 10.6 CD8A CD40LG CD4
46 coccidioidomycosis 10.6 CD40LG CD4 CCR6
47 uveoparotid fever 10.6 CD8A CD40LG CD4
48 tertiary neurosyphilis 10.6 CD40LG CD4
49 duodenitis 10.6 CD8A CD40LG CD4
50 cerebral lymphoma 10.6 CD40LG CD4 CD19

Graphical network of the top 20 diseases related to Autoimmune Disease of Blood:



Diseases related to Autoimmune Disease of Blood

Symptoms & Phenotypes for Autoimmune Disease of Blood

MGI Mouse Phenotypes related to Autoimmune Disease of Blood:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 ADAMTS13 CCR6 CD19 CD4 CD40LG CD5
2 cellular MP:0005384 10.11 CD19 CD4 CD40LG CD8A F3 FOXP3
3 homeostasis/metabolism MP:0005376 10.1 ADAMTS13 CCR6 CD19 CD4 CD40LG F3
4 immune system MP:0005387 10.06 ADAMTS13 CCR6 CD19 CD4 CD40LG CD5
5 integument MP:0010771 9.61 CD19 CD4 CD40LG CD5 CD8A F3
6 normal MP:0002873 9.32 ADAMTS13 CCR6 CD19 CD4 CD5 CD8A

Drugs & Therapeutics for Autoimmune Disease of Blood

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Blood

Genetic Tests for Autoimmune Disease of Blood

Anatomical Context for Autoimmune Disease of Blood

MalaCards organs/tissues related to Autoimmune Disease of Blood:

40
T Cells, B Cells, Eye, Thymus, Skin, Bone, Myeloid

Publications for Autoimmune Disease of Blood

Variations for Autoimmune Disease of Blood

Expression for Autoimmune Disease of Blood

Search GEO for disease gene expression data for Autoimmune Disease of Blood.

Pathways for Autoimmune Disease of Blood

Pathways related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 TNFSF13B ITGB3 ITGA2B IL10 ICOSLG HP
2
Show member pathways
13.26 TNFSF13B THPO ITGB3 ITGA2B IL10 CD40LG
3
Show member pathways
12.65 TNFSF13B IL10 ICOSLG FOXP3 CD8A CD40LG
4 12.32 TNFSF13B MPL IL10 FOXP3 CD8A CD40LG
5 11.96 ICOSLG CD8A CD40LG CD4
6
Show member pathways
11.75 THPO MPL ITGB3 ITGA2B
7 11.64 IL10 CD8A CD4 CCR6
8 11.57 IL10 CD8A CD4 CD19
9 11.51 ITGB3 IL10 CD40LG
10 11.5 THPO ITGB3 ITGA2B CD8A CD5 CD4
11 11.36 IL10 FOXP3 CD4
12 11.34 THPO MPL ITGB3 ITGA2B IL10 CD8A
13 11.28 IL10 CD5 CD40LG CD4 CD19
14 11.2 CD8A CD40LG CD4 CD19
15 10.86 TNFSF13B THPO ITGB3 ITGA2B IL10 CD40LG

GO Terms for Autoimmune Disease of Blood

Cellular components related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 TNFSF13B MPL ITGB3 ITGA2B ICOSLG F3
2 integral component of membrane GO:0016021 10.13 TNFSF13B RHD RHCE MPL ITGB3 ITGA2B
3 extracellular region GO:0005576 10.02 TNFSF13B THPO IL10 HP F3 CD8A
4 integral component of plasma membrane GO:0005887 9.81 RHD RHCE ITGB3 CD8A CD5 CD40LG
5 cell surface GO:0009986 9.56 MPL ITGB3 ITGA2B F3 CD40LG CD4
6 external side of plasma membrane GO:0009897 9.23 ITGA2B ICOSLG CD8A CD5 CD40LG CD4

Biological processes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 TNFSF13B IL10 CD8A CD40LG CD4 CCR6
2 positive regulation of endothelial cell proliferation GO:0001938 9.67 ITGB3 IL10 F3
3 positive regulation of T cell proliferation GO:0042102 9.65 TNFSF13B CD40LG CD4
4 integrin-mediated signaling pathway GO:0007229 9.56 ITGB3 ITGA2B CD40LG ADAMTS13
5 regulation of immune response GO:0050776 9.55 TNFSF13B ICOSLG CD8A CD40LG CD19
6 platelet aggregation GO:0070527 9.54 MPL ITGB3 ITGA2B
7 T cell mediated immunity GO:0002456 9.52 FOXP3 CD8A
8 ammonium transmembrane transport GO:0072488 9.51 RHD RHCE
9 ammonium transport GO:0015696 9.46 RHD RHCE
10 immunoglobulin secretion GO:0048305 9.43 TNFSF13B CD40LG
11 thrombopoietin-mediated signaling pathway GO:0038163 9.4 THPO MPL
12 T cell costimulation GO:0031295 9.26 TNFSF13B ICOSLG CD5 CD40LG
13 T cell activation GO:0042110 8.92 ICOSLG FOXP3 CD8A CD4

Molecular functions related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 TNFSF13B THPO IL10 CD40LG
2 ammonium transmembrane transporter activity GO:0008519 9.16 RHD RHCE
3 fibrinogen binding GO:0070051 8.96 ITGB3 ITGA2B
4 coreceptor activity GO:0015026 8.8 ITGB3 CD8A CD4

Sources for Autoimmune Disease of Blood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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