MCID: ATM012
MIFTS: 32

Autoimmune Disease of Blood

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Blood

MalaCards integrated aliases for Autoimmune Disease of Blood:

Name: Autoimmune Disease of Blood 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060050

Summaries for Autoimmune Disease of Blood

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.

MalaCards based summary : Autoimmune Disease of Blood is related to anemia, autoimmune hemolytic and thrombocytopenia 3. An important gene associated with Autoimmune Disease of Blood is THPO (Thrombopoietin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Phospholipase-C Pathway. The drugs Sirolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Related Diseases for Autoimmune Disease of Blood

Diseases related to Autoimmune Disease of Blood via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 anemia, autoimmune hemolytic 30.6 CD5 GYPA HP RHCE RHD
2 thrombocytopenia 3 10.4 MPL THPO
3 thrombocythemia 1 10.4 MPL THPO
4 bleeding disorder, platelet-type, 16 10.3 ITGA2B ITGB3
5 dyskeratosis congenita, autosomal dominant 6 10.3 MPL THPO
6 thrombotic thrombocytopenic purpura, congenital 10.3 ADAMTS13 HP
7 amegakaryocytic thrombocytopenia, congenital 10.2 MPL THPO
8 aspirin resistance 10.2 ITGA2 ITGB3
9 retinohepatoendocrinologic syndrome 10.2 RHCE RHD
10 blood group incompatibility 10.2 RHCE RHD
11 evans' syndrome 10.2 ADAMTS13 HP
12 polycythemia vera 10.2 ITGB3 MPL THPO
13 bombay phenotype 10.1 ADAMTS13 VWF
14 megakaryocytic leukemia 10.1 ITGA2B THPO VWF
15 autosomal dominant macrothrombocytopenia 10.0 GP1BA ITGA2B ITGB3
16 thrombocytopenia-absent radius syndrome 10.0 GP1BA MPL THPO
17 hemolytic-uremic syndrome 10.0 ADAMTS13 HP VWF
18 hellp syndrome 10.0 ADAMTS13 HP VWF
19 bone marrow cancer 10.0 ITGB3 MPL THPO VWF
20 adult lymphoma 9.9 CD5 FCGR2A
21 acquired von willebrand syndrome 9.9 GP1BA VWF
22 pseudo-von willebrand disease 9.9 GP1BA VWF
23 coronary thrombosis 9.9 GP1BA ITGB3 VWF
24 infective endocarditis 9.9 FCGR2A GP1BA ITGB3
25 bleeding disorder, platelet-type, 11 9.9 FCGR2A ITGA2
26 intracranial thrombosis 9.8 ITGA2B VWF
27 thrombosis 9.8 ADAMTS13 GP1BA VWF
28 von willebrand's disease 9.8 ADAMTS13 GP1BA VWF
29 fetal erythroblastosis 9.8 GYPA RHCE RHD
30 fetal and neonatal alloimmune thrombocytopenia 9.8 GP1BA ITGA2 ITGA2B ITGB3
31 thrombasthenia 9.8 GP1BA ITGA2 ITGA2B ITGB3
32 thrombocytopenic purpura, autoimmune 9.8 GP1BA ITGA2B ITGB3 MPL THPO
33 inherited blood coagulation disease 9.7 GP1BA ITGA2B ITGB3 VWF
34 purpura 9.7 ADAMTS13 ITGA2B ITGB3 MPL THPO VWF
35 vascular disease 9.7 GP1BA HP ITGB3 VWF
36 glanzmann thrombasthenia 9.5 GP1BA ITGA2 ITGA2B ITGB3 VWF
37 essential thrombocythemia 9.5 GP1BA ITGA2B ITGB3 MPL THPO VWF
38 hemorrhagic disease 9.5 ADAMTS13 GP1BA ITGA2B MPL THPO VWF
39 thrombocytopenia 9.4 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 MPL
40 bernard-soulier syndrome 9.4 GP1BA ITGA2 ITGA2B ITGB3 THPO VWF
41 von willebrand disease, type 2 9.4 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 VWF
42 thrombocytopenia due to platelet alloimmunization 9.4 FCGR2A FCGR2B ITGA2 ITGA2B ITGB3 MPL
43 myocardial infarction 9.3 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 VWF
44 blood coagulation disease 9.3 ADAMTS13 GP1BA ITGA2B ITGB3 MPL THPO
45 blood platelet disease 9.3 ADAMTS13 GP1BA ITGA2B ITGB3 MPL THPO
46 malaria 8.8 ADAMTS13 FCGR2A FCGR2B GYPA HP RHD
47 primary thrombocytopenia 8.6 ADAMTS13 FCGR2A FOXG1 GP1BA ITGA2 ITGA2B

Graphical network of the top 20 diseases related to Autoimmune Disease of Blood:



Diseases related to Autoimmune Disease of Blood

Symptoms & Phenotypes for Autoimmune Disease of Blood

GenomeRNAi Phenotypes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD5 FCGR2A GP1BA ITGA2 ITGA2B THPO

MGI Mouse Phenotypes related to Autoimmune Disease of Blood:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 ADAMTS13 CD5 FCGR2A FCGR2B FOXG1 GP1BA
2 cellular MP:0005384 9.91 FCGR2B FOXG1 GP1BA HP ITGA2 ITGA2B
3 homeostasis/metabolism MP:0005376 9.73 ADAMTS13 FCGR2B FOXG1 GP1BA HP ITGA2
4 immune system MP:0005387 9.36 ADAMTS13 CD5 FCGR2A FCGR2B FOXG1 HP

Drugs & Therapeutics for Autoimmune Disease of Blood

Drugs for Autoimmune Disease of Blood (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 5284616 6436030
2
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
3
Everolimus Approved Phase 1, Phase 2 159351-69-6 70789204 6442177
4 Anti-Bacterial Agents Phase 1, Phase 2
5 Immunosuppressive Agents Phase 1, Phase 2
6 Anti-Infective Agents Phase 1, Phase 2
7 Antifungal Agents Phase 1, Phase 2
8 Antibiotics, Antitubercular Phase 1, Phase 2
9 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sirolimus for Autoimmune Disease of Blood Cells Active, not recruiting NCT00392951 Phase 1, Phase 2 sirolimus

Search NIH Clinical Center for Autoimmune Disease of Blood

Genetic Tests for Autoimmune Disease of Blood

Anatomical Context for Autoimmune Disease of Blood

MalaCards organs/tissues related to Autoimmune Disease of Blood:

42
T Cells, Bone, Bone Marrow

Publications for Autoimmune Disease of Blood

Variations for Autoimmune Disease of Blood

Expression for Autoimmune Disease of Blood

Search GEO for disease gene expression data for Autoimmune Disease of Blood.

Pathways for Autoimmune Disease of Blood

Pathways related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 GP1BA GYPA ITGA2 ITGA2B ITGB3 MPL
2
Show member pathways
12.89 FCGR2A FCGR2B ITGA2 ITGA2B ITGB3 THPO
3
Show member pathways
12.04 ITGA2 ITGA2B ITGB3
4 11.96 FCGR2A FCGR2B ITGA2 ITGB3
5
Show member pathways
11.95 GP1BA ITGA2 ITGA2B ITGB3 VWF
6
Show member pathways
11.9 ITGA2B ITGB3 VWF
7 11.87 FCGR2A FCGR2B ITGB3
8
Show member pathways
11.85 ITGA2 ITGA2B ITGB3
9 11.83 FCGR2A GP1BA ITGA2 ITGA2B ITGB3 VWF
10 11.79 ITGA2 ITGA2B ITGB3
11 11.69 FCGR2A ITGA2 ITGA2B ITGB3
12
Show member pathways
11.62 GP1BA ITGA2B ITGB3 MPL THPO VWF
13 11.57 FCGR2A FCGR2B ITGB3
14 11.56 ITGA2 ITGA2B ITGB3 THPO
15 11.49 CD5 GP1BA GYPA ITGA2 ITGA2B ITGB3
16 11.47 ITGA2 ITGA2B ITGB3
17 11.47 ITGA2 ITGA2B ITGB3
18 11.39 FCGR2A ITGA2B ITGB3
19 11.35 GYPA ITGA2B ITGB3
20 11.34 CD5 FCGR2A GP1BA GYPA ITGA2 ITGA2B
21 11.33 ITGA2 ITGA2B ITGB3 VWF
22 11.05 ITGA2B ITGB3
23 10.92 ITGA2B ITGB3
24 10.69 GP1BA ITGA2 VWF
25 10.56 GP1BA VWF

GO Terms for Autoimmune Disease of Blood

Cellular components related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.7 CD5 FCGR2B GP1BA ITGB3 MPL RHCE
2 external side of plasma membrane GO:0009897 9.62 CD5 FCGR2B ITGA2 ITGA2B
3 cell surface GO:0009986 9.43 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 MPL
4 platelet alpha granule membrane GO:0031092 9.26 ITGA2B ITGB3
5 integrin complex GO:0008305 8.8 ITGA2 ITGA2B ITGB3
6 integral component of membrane GO:0016021 10.11 CD5 FCGR2A FCGR2B GP1BA GYPA ITGA2

Biological processes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.93 GP1BA ITGA2 ITGA2B ITGB3 VWF
2 viral process GO:0016032 9.9 FCGR2B GYPA ITGA2 ITGB3
3 cell proliferation GO:0008283 9.88 CD5 ITGA2 MPL THPO
4 extracellular matrix organization GO:0030198 9.76 ITGA2 ITGA2B ITGB3 VWF
5 platelet degranulation GO:0002576 9.75 ITGA2B ITGB3 VWF
6 viral entry into host cell GO:0046718 9.69 GYPA ITGA2 ITGB3
7 platelet activation GO:0030168 9.67 ADAMTS13 GP1BA ITGB3 VWF
8 cell-matrix adhesion GO:0007160 9.62 ADAMTS13 ITGA2 ITGA2B ITGB3
9 hemostasis GO:0007599 9.61 ADAMTS13 GP1BA VWF
10 cell adhesion mediated by integrin GO:0033627 9.59 ITGA2 ITGB3
11 blood coagulation, intrinsic pathway GO:0007597 9.57 GP1BA VWF
12 mesodermal cell differentiation GO:0048333 9.56 ITGA2 ITGB3
13 integrin-mediated signaling pathway GO:0007229 9.56 ADAMTS13 ITGA2 ITGA2B ITGB3
14 positive regulation of leukocyte migration GO:0002687 9.55 ITGA2 ITGA2B
15 response to amine GO:0014075 9.52 ADAMTS13 ITGA2
16 ammonium transmembrane transport GO:0072488 9.49 RHCE RHD
17 ammonium transport GO:0015696 9.48 RHCE RHD
18 thrombopoietin-mediated signaling pathway GO:0038163 9.4 MPL THPO
19 blood coagulation GO:0007596 9.35 ADAMTS13 GP1BA ITGA2 ITGB3 VWF
20 cell-substrate adhesion GO:0031589 9.33 ITGA2 ITGB3 VWF
21 platelet aggregation GO:0070527 8.92 GP1BA ITGA2B ITGB3 MPL

Molecular functions related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.43 GYPA ITGA2 ITGB3
2 IgG binding GO:0019864 9.32 FCGR2A FCGR2B
3 ammonium transmembrane transporter activity GO:0008519 9.16 RHCE RHD
4 fibrinogen binding GO:0070051 8.96 ITGA2B ITGB3
5 integrin binding GO:0005178 8.92 ADAMTS13 ITGA2 ITGB3 VWF

Sources for Autoimmune Disease of Blood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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