MCID: ATM012
MIFTS: 31

Autoimmune Disease of Blood

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Autoimmune Disease of Blood

MalaCards integrated aliases for Autoimmune Disease of Blood:

Name: Autoimmune Disease of Blood 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060050

Summaries for Autoimmune Disease of Blood

Disease Ontology : 12 A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.

MalaCards based summary : Autoimmune Disease of Blood is related to anemia, autoimmune hemolytic and selective igg deficiency disease. An important gene associated with Autoimmune Disease of Blood is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Phospholipase-C Pathway. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and Reduced mammosphere formation

Related Diseases for Autoimmune Disease of Blood

Diseases related to Autoimmune Disease of Blood via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 anemia, autoimmune hemolytic 28.1 C3 CD40LG CD5 CD79A GYPA HP
2 selective igg deficiency disease 10.9 CD40LG CD79A
3 c1q nephropathy 10.9 CD40LG CD79A
4 meningovascular neurosyphilis 10.9 CD40LG CD79A
5 alpha chain disease 10.9 CD40LG CD79A
6 brill-zinsser disease 10.9 CD40LG CD79A
7 exudative glomerulonephritis 10.9 CD40LG CD79A
8 cork-handlers' disease 10.9 CD40LG CD79A
9 salpingo-oophoritis 10.9 CD40LG CD79A
10 early yaws 10.9 CD40LG CD79A
11 ventilation pneumonitis 10.9 CD40LG CD79A
12 chronic interstitial cystitis 10.9 CD40LG CD79A
13 axillary adenitis 10.9 CD40LG CD79A
14 trichostrongyloidiasis 10.9 CD40LG CD79A
15 subacute bacterial endocarditis 10.9 CD40LG CD79A
16 heterophyiasis 10.9 CD40LG CD79A
17 immunoglobulin g deficiency 10.9 CD40LG CD79A
18 orbital granuloma 10.9 CD40LG CD79A
19 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
20 hyperglobulinemic purpura 10.9 CD40LG CD79A
21 gastroduodenitis 10.9 CD40LG CD79A
22 bacterial conjunctivitis 10.9 CD40LG CD79A
23 thrombocytopenia 3 10.9 MPL THPO
24 heavy chain disease 10.9 CD40LG CD79A
25 ophthalmia neonatorum 10.9 CD40LG CD79A
26 thrombocythemia 1 10.9 MPL THPO
27 immunoglobulin a deficiency 1 10.9 CD40LG CD79A
28 parotid disease 10.9 CD40LG CD79A
29 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
30 amegakaryocytic thrombocytopenia, congenital 10.8 MPL THPO
31 erythema elevatum diutinum 10.8 CD40LG CD79A
32 sporotrichosis 10.8 CD40LG CD79A
33 fallopian tube disease 10.8 CD40LG CD79A
34 hyperimmunoglobulin syndrome 10.8 CD40LG CD79A
35 congenital syphilis 10.8 CD40LG CD79A
36 dyskeratosis congenita, autosomal dominant 6 10.8 MPL THPO
37 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A
38 salpingitis 10.8 CD40LG CD79A
39 ocular toxoplasmosis 10.8 CD40LG CD79A
40 dysgammaglobulinemia 10.8 CD40LG CD79A
41 congenital hypogammaglobulinemia 10.8 CD40LG CD79A
42 bleeding disorder, platelet-type, 16 10.8 ITGA2B ITGB3
43 chronic polyneuropathy 10.8 CD40LG CD79A
44 spinocerebellar ataxia, autosomal recessive 10 10.8 CD40LG CD79A
45 parasitic ichthyosporea infectious disease 10.8 CD40LG CD79A
46 cd40 ligand deficiency 10.8 CD40LG CD79A
47 rhinosporidiosis 10.7 CD40LG CD79A
48 secondary syphilis 10.7 CD40LG CD79A
49 thrombotic thrombocytopenic purpura, congenital 10.7 ADAMTS13 HP
50 yellow nail syndrome 10.7 CD40LG CD79A

Graphical network of the top 20 diseases related to Autoimmune Disease of Blood:



Diseases related to Autoimmune Disease of Blood

Symptoms & Phenotypes for Autoimmune Disease of Blood

GenomeRNAi Phenotypes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 9.56 C3 CD40LG CD5 HP ITGA2B ITGB3
2 Reduced mammosphere formation GR00396-S 9.1 C3 CD5 CD79A ITGA2 ITGA2B THPO

MGI Mouse Phenotypes related to Autoimmune Disease of Blood:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ITGA2 ITGA2B ITGB3 ADAMTS13 C3 MPL
2 cellular MP:0005384 9.91 HP ITGA2 ITGA2B ITGB3 C3 MPL
3 homeostasis/metabolism MP:0005376 9.73 HP ITGA2 ITGA2B ITGB3 ADAMTS13 C3
4 immune system MP:0005387 9.36 ITGA2B ITGB3 ADAMTS13 C3 MPL CD40LG

Drugs & Therapeutics for Autoimmune Disease of Blood

Drugs for Autoimmune Disease of Blood (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 1, Phase 2
5 Antibiotics, Antitubercular Phase 1, Phase 2
6 Antifungal Agents Phase 1, Phase 2
7 Anti-Infective Agents Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sirolimus for Autoimmune Disease of Blood Cells Active, not recruiting NCT00392951 Phase 1, Phase 2 sirolimus

Search NIH Clinical Center for Autoimmune Disease of Blood

Genetic Tests for Autoimmune Disease of Blood

Anatomical Context for Autoimmune Disease of Blood

MalaCards organs/tissues related to Autoimmune Disease of Blood:

41
T Cells

Publications for Autoimmune Disease of Blood

Variations for Autoimmune Disease of Blood

Expression for Autoimmune Disease of Blood

Search GEO for disease gene expression data for Autoimmune Disease of Blood.

Pathways for Autoimmune Disease of Blood

Pathways related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 GYPA ITGA2 ITGA2B ITGB3 MPL THPO
2
Show member pathways
12.82 CD79A ITGA2 ITGA2B ITGB3 THPO
3
Show member pathways
12.68 CD40LG CD79A ITGA2 ITGA2B ITGB3
4 11.93 C3 ITGA2 ITGB3
5
Show member pathways
11.88 ITGA2 ITGA2B ITGB3 VWF
6
Show member pathways
11.86 ITGA2B ITGB3 VWF
7
Show member pathways
11.78 ITGA2 ITGA2B ITGB3
8 11.76 ITGA2 ITGA2B ITGB3 VWF
9 11.55 C3 ITGA2 ITGA2B ITGB3
10
Show member pathways
11.54 ITGA2B ITGB3 MPL THPO VWF
11 11.42 ITGA2 ITGA2B ITGB3
12 11.42 CD5 GYPA ITGA2 ITGA2B ITGB3 THPO
13 11.41 ITGA2 ITGA2B ITGB3
14 11.31 GYPA ITGA2B ITGB3
15 11.29 CD5 CD79A GYPA ITGA2 ITGA2B ITGB3
16 11.27 ITGA2 ITGA2B ITGB3 VWF
17 10.88 ITGA2B ITGB3
18 10.61 ITGA2 VWF

GO Terms for Autoimmune Disease of Blood

Cellular components related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 CD40LG CD5 CD79A ITGB3 MPL RHCE
2 cell surface GO:0009986 9.63 ADAMTS13 CD40LG ITGA2 ITGA2B ITGB3 MPL
3 platelet alpha granule membrane GO:0031092 9.32 ITGA2B ITGB3
4 integrin complex GO:0008305 9.13 ITGA2 ITGA2B ITGB3
5 external side of plasma membrane GO:0009897 9.02 CD40LG CD5 CD79A ITGA2 ITGA2B

Biological processes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.88 CD5 ITGA2 MPL THPO
2 platelet degranulation GO:0002576 9.74 ITGA2B ITGB3 VWF
3 extracellular matrix organization GO:0030198 9.73 ITGA2 ITGA2B ITGB3 VWF
4 blood coagulation GO:0007596 9.71 ADAMTS13 ITGA2 ITGB3 VWF
5 viral entry into host cell GO:0046718 9.65 GYPA ITGA2 ITGB3
6 organic cation transport GO:0015695 9.56 RHCE RHD
7 platelet activation GO:0030168 9.56 ADAMTS13 CD40LG ITGB3 VWF
8 cell adhesion mediated by integrin GO:0033627 9.55 ITGA2 ITGB3
9 positive regulation of leukocyte migration GO:0002687 9.54 ITGA2 ITGA2B
10 platelet aggregation GO:0070527 9.54 ITGA2B ITGB3 MPL
11 mesodermal cell differentiation GO:0048333 9.52 ITGA2 ITGB3
12 response to amine GO:0014075 9.51 ADAMTS13 ITGA2
13 ammonium transmembrane transport GO:0072488 9.49 RHCE RHD
14 ammonium transport GO:0015696 9.46 RHCE RHD
15 cell-matrix adhesion GO:0007160 9.46 ADAMTS13 ITGA2 ITGA2B ITGB3
16 thrombopoietin-mediated signaling pathway GO:0038163 9.32 MPL THPO
17 integrin-mediated signaling pathway GO:0007229 9.26 ADAMTS13 ITGA2 ITGA2B ITGB3
18 cell-substrate adhesion GO:0031589 8.8 ITGA2 ITGB3 VWF

Molecular functions related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.33 GYPA ITGA2 ITGB3
2 ammonium transmembrane transporter activity GO:0008519 8.96 RHCE RHD
3 integrin binding GO:0005178 8.92 ADAMTS13 ITGA2 ITGB3 VWF

Sources for Autoimmune Disease of Blood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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