MCID: ATM012
MIFTS: 24

Autoimmune Disease of Blood

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Blood

MalaCards integrated aliases for Autoimmune Disease of Blood:

Name: Autoimmune Disease of Blood 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060050

Summaries for Autoimmune Disease of Blood

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.

MalaCards based summary : Autoimmune Disease of Blood is related to anemia, autoimmune hemolytic and thrombocytopenia 3. An important gene associated with Autoimmune Disease of Blood is THPO (Thrombopoietin), and among its related pathways/superpathways are Akt Signaling and Phospholipase-C Pathway. Affiliated tissues include t cells, and related phenotypes are hematopoietic system and cellular

Related Diseases for Autoimmune Disease of Blood

Diseases related to Autoimmune Disease of Blood via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 anemia, autoimmune hemolytic 30.6 RHD RHCE HP CD5 CD40LG
2 thrombocytopenia 3 10.6 THPO MPL
3 thrombocythemia 1 10.6 THPO MPL
4 cryofibrinogenemia 10.6 HP CD40LG
5 dyskeratosis congenita, autosomal dominant 6 10.6 THPO MPL
6 bleeding disorder, platelet-type, 16 10.6 ITGB3 ITGA2B
7 thrombotic thrombocytopenic purpura, congenital 10.5 HP ADAMTS13
8 autosomal dominant macrothrombocytopenia 10.5 ITGB3 ITGA2B
9 exanthema subitum 10.4 THPO ITGA2B CD40LG
10 catastrophic antiphospholipid syndrome 10.4 CD40LG ADAMTS13
11 heparin-induced thrombocytopenia 10.3 FCGR2A CD40LG
12 metal allergy 10.3 CD8A CD4
13 blood group incompatibility 10.3 RHD RHCE
14 amegakaryocytic thrombocytopenia, congenital 10.3 THPO MPL
15 retinohepatoendocrinologic syndrome 10.3 RHD RHCE
16 polycythemia vera 10.3 THPO MPL ITGB3
17 polyclonal hypergammaglobulinemia 10.2 CD8A CD4
18 bone marrow cancer 10.2 THPO MPL ITGB3
19 evans' syndrome 10.2 HP ADAMTS13
20 thrombocytopenic purpura, autoimmune 10.2 THPO MPL ITGB3 ITGA2B
21 essential thrombocythemia 10.2 THPO MPL ITGB3 ITGA2B
22 cryoglobulinemia, familial mixed 10.2 CD5 CD40LG
23 multifocal motor neuropathy 10.2 FCGR2B CD40LG
24 hemorrhagic disease 10.1 THPO MPL ITGA2B ADAMTS13
25 aspirin resistance 10.0 ITGB3 ITGA2
26 blood coagulation disease 9.9 THPO MPL ITGB3 ITGA2B ADAMTS13
27 blood platelet disease 9.9 THPO MPL ITGB3 ITGA2B ADAMTS13
28 purpura 9.9 THPO MPL ITGB3 ITGA2B ADAMTS13
29 fetal and neonatal alloimmune thrombocytopenia 9.9 ITGB3 ITGA2B ITGA2
30 autoimmune disease of musculoskeletal system 9.9 FCGR2B FCGR2A CD40LG
31 thrombasthenia 9.9 ITGB3 ITGA2B ITGA2
32 glanzmann thrombasthenia 9.8 ITGB3 ITGA2B ITGA2
33 intestine carcinoma in situ 9.8 ITGA2 CD40LG
34 thymus lipoma 9.8 CD8A CD5 CD4
35 immune system organ benign neoplasm 9.8 CD8A CD5 CD4
36 fetal erythroblastosis 9.7 RHD RHCE
37 autoimmune disease 9.7
38 bernard-soulier syndrome 9.7 THPO ITGB3 ITGA2B ITGA2
39 colon carcinoma in situ 9.6 ITGA2 CD40LG
40 von willebrand disease, type 2 9.6 ITGB3 ITGA2B ITGA2 ADAMTS13
41 myocardial infarction 9.3 ITGB3 ITGA2B ITGA2 CD40LG ADAMTS13
42 thrombocytopenia 9.2 THPO MPL ITGB3 ITGA2B ITGA2 ADAMTS13
43 malaria 8.9 RHD HP FCGR2B FCGR2A CD40LG ADAMTS13
44 thrombocytopenia due to platelet alloimmunization 8.5 THPO MPL ITGB3 ITGA2B ITGA2 FCGR2B
45 primary thrombocytopenia 8.1 THPO MPL ITGB3 ITGA2B ITGA2 FOXG1

Graphical network of the top 20 diseases related to Autoimmune Disease of Blood:



Diseases related to Autoimmune Disease of Blood

Symptoms & Phenotypes for Autoimmune Disease of Blood

MGI Mouse Phenotypes related to Autoimmune Disease of Blood:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 ADAMTS13 CD4 CD40LG CD5 CD8A FCGR2A
2 cellular MP:0005384 10.07 CD4 CD40LG CD8A FCGR2B FOXG1 HP
3 homeostasis/metabolism MP:0005376 10.03 ADAMTS13 CD4 CD40LG FCGR2B FOXG1 HP
4 immune system MP:0005387 9.97 ADAMTS13 CD4 CD40LG CD5 CD8A FCGR2A
5 integument MP:0010771 9.5 CD4 CD40LG CD5 CD8A FOXG1 ITGA2
6 normal MP:0002873 9.23 ADAMTS13 CD4 CD5 CD8A FCGR2B FOXG1

Drugs & Therapeutics for Autoimmune Disease of Blood

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Blood

Genetic Tests for Autoimmune Disease of Blood

Anatomical Context for Autoimmune Disease of Blood

MalaCards organs/tissues related to Autoimmune Disease of Blood:

41
T Cells

Publications for Autoimmune Disease of Blood

Variations for Autoimmune Disease of Blood

Expression for Autoimmune Disease of Blood

Search GEO for disease gene expression data for Autoimmune Disease of Blood.

Pathways for Autoimmune Disease of Blood

Pathways related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 THPO ITGB3 ITGA2B ITGA2 CD40LG CD4
2
Show member pathways
12.85 THPO ITGB3 ITGA2B ITGA2 FCGR2B FCGR2A
3
Show member pathways
11.98 ITGB3 ITGA2B ITGA2
4 11.93 CD8A CD40LG CD4
5 11.89 ITGB3 ITGA2 FCGR2B FCGR2A
6 11.88 FCGR2B CD8A CD40LG
7 11.85 ITGB3 FCGR2B FCGR2A
8
Show member pathways
11.83 ITGB3 ITGA2B ITGA2
9 11.79 ITGB3 ITGA2B ITGA2
10 11.72 ITGB3 ITGA2B ITGA2 FCGR2A
11 11.55 ITGB3 FCGR2B FCGR2A
12
Show member pathways
11.55 THPO MPL ITGB3 ITGA2B
13 11.54 THPO ITGB3 ITGA2B ITGA2
14 11.49 THPO ITGB3 ITGA2B ITGA2 CD8A CD5
15 11.46 ITGB3 ITGA2B ITGA2
16 11.44 ITGB3 ITGA2B ITGA2
17 11.4 CD5 CD40LG CD4
18 11.39 ITGB3 ITGA2B ITGA2 FCGR2A
19 11.34 ITGB3 ITGA2B ITGA2
20 11.34 THPO MPL ITGB3 ITGA2B ITGA2 FCGR2A
21 11.31 ITGB3 ITGA2B FCGR2A
22 11.11 CD8A CD40LG CD4
23 11.05 ITGB3 ITGA2B
24 10.91 ITGB3 ITGA2B
25 10.84 THPO ITGB3 ITGA2B ITGA2 CD40LG

GO Terms for Autoimmune Disease of Blood

Cellular components related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.7 MPL ITGB3 ITGA2B ITGA2 CD40LG CD4
2 integral component of plasma membrane GO:0005887 9.56 RHD RHCE ITGB3 FCGR2B CD8A CD5
3 integrin complex GO:0008305 9.43 ITGB3 ITGA2B ITGA2
4 platelet alpha granule membrane GO:0031092 9.4 ITGB3 ITGA2B
5 T cell receptor complex GO:0042101 9.37 CD8A CD4
6 external side of plasma membrane GO:0009897 9.17 ITGA2B ITGA2 FCGR2B CD8A CD5 CD40LG
7 integral component of membrane GO:0016021 10.1 RHD RHCE MPL ITGB3 ITGA2B ITGA2

Biological processes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.84 ITGB3 ITGA2 FCGR2B CD4
2 cell proliferation GO:0008283 9.69 THPO ITGA2 CD5
3 platelet activation GO:0030168 9.65 ITGB3 CD40LG ADAMTS13
4 cell adhesion mediated by integrin GO:0033627 9.52 ITGB3 ITGA2
5 cell-substrate adhesion GO:0031589 9.49 ITGB3 ITGA2
6 positive regulation of leukocyte migration GO:0002687 9.46 ITGA2B ITGA2
7 mesodermal cell differentiation GO:0048333 9.43 ITGB3 ITGA2
8 response to amine GO:0014075 9.4 ITGA2 ADAMTS13
9 ammonium transmembrane transport GO:0072488 9.37 RHD RHCE
10 platelet aggregation GO:0070527 9.33 MPL ITGB3 ITGA2B
11 ammonium transport GO:0015696 9.32 RHD RHCE
12 thrombopoietin-mediated signaling pathway GO:0038163 9.26 THPO MPL
13 integrin-mediated signaling pathway GO:0007229 9.26 ITGB3 ITGA2B ITGA2 ADAMTS13
14 cell-matrix adhesion GO:0007160 8.92 ITGB3 ITGA2B ITGA2 ADAMTS13

Molecular functions related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.54 ITGB3 ITGA2 ADAMTS13
2 virus receptor activity GO:0001618 9.43 ITGB3 ITGA2 CD4
3 IgG binding GO:0019864 9.32 FCGR2B FCGR2A
4 ammonium transmembrane transporter activity GO:0008519 9.16 RHD RHCE
5 fibrinogen binding GO:0070051 8.96 ITGB3 ITGA2B
6 coreceptor activity GO:0015026 8.8 ITGB3 CD8A CD4

Sources for Autoimmune Disease of Blood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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