MCID: ATM012
MIFTS: 29

Autoimmune Disease of Blood

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Blood

MalaCards integrated aliases for Autoimmune Disease of Blood:

Name: Autoimmune Disease of Blood 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060050

Summaries for Autoimmune Disease of Blood

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.

MalaCards based summary : Autoimmune Disease of Blood is related to anemia, autoimmune hemolytic and thrombocytopenia 3. An important gene associated with Autoimmune Disease of Blood is THPO (Thrombopoietin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Phospholipase-C Pathway. The drugs Everolimus and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Related Diseases for Autoimmune Disease of Blood

Diseases related to Autoimmune Disease of Blood via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 anemia, autoimmune hemolytic 30.9 CD5 GYPA HP RHCE RHD
2 thrombocytopenia 3 10.3 MPL THPO
3 thrombocythemia 1 10.2 MPL THPO
4 dyskeratosis congenita, autosomal dominant 6 10.2 MPL THPO
5 bleeding disorder, platelet-type, 16 10.2 ITGA2B ITGB3
6 thrombotic thrombocytopenic purpura, congenital 10.2 ADAMTS13 HP
7 aspirin resistance 10.2 ITGA2 ITGB3
8 amegakaryocytic thrombocytopenia, congenital 10.2 MPL THPO
9 retinohepatoendocrinologic syndrome 10.2 RHCE RHD
10 blood group incompatibility 10.2 RHCE RHD
11 bombay phenotype 10.1 ADAMTS13 VWF
12 evans' syndrome 10.1 ADAMTS13 HP
13 autosomal dominant macrothrombocytopenia 10.1 GP1BA ITGA2B ITGB3
14 thrombocytopenia-absent radius syndrome 10.1 GP1BA MPL THPO
15 megakaryocytic leukemia 10.1 ITGA2B THPO VWF
16 hemolytic-uremic syndrome 10.0 ADAMTS13 HP VWF
17 hellp syndrome 10.0 ADAMTS13 HP VWF
18 acquired von willebrand syndrome 10.0 GP1BA VWF
19 infective endocarditis 10.0 FCGR2A GP1BA ITGB3
20 adult lymphoma 10.0 CD5 FCGR2A
21 pseudo-von willebrand disease 10.0 GP1BA VWF
22 fetal erythroblastosis 10.0 GYPA RHCE RHD
23 coronary thrombosis 10.0 GP1BA ITGB3 VWF
24 bleeding disorder, platelet-type, 11 10.0 FCGR2A ITGA2
25 thrombocytosis 10.0 MPL SELP THPO
26 fetal and neonatal alloimmune thrombocytopenia 10.0 GP1BA ITGA2 ITGA2B ITGB3
27 carotid artery thrombosis 9.9 ITGA2B SELP
28 intracranial thrombosis 9.9 ITGA2B VWF
29 qualitative platelet defect 9.9 SELP VWF
30 platelet aggregation, spontaneous 9.9 SELP VWF
31 inherited blood coagulation disease 9.9 GP1BA ITGA2B ITGB3 VWF
32 polycythemia vera 9.9 ITGB3 MPL SELP THPO
33 intermediate coronary syndrome 9.9 ITGA2B SELP VWF
34 arteries, anomalies of 9.8 ITGA2B SELP VWF
35 thrombotic thrombocytopenic purpura 9.8 ADAMTS13 SELP VWF
36 antiphospholipid syndrome 9.8 ADAMTS13 SELP VWF
37 purpura 9.8 ADAMTS13 ITGA2B ITGB3 MPL THPO VWF
38 cerebrovascular disease 9.8 ITGA2B SELP VWF
39 acute myocardial infarction 9.8 ITGA2B SELP VWF
40 hemorrhagic disease 9.7 ADAMTS13 GP1BA ITGA2B MPL THPO VWF
41 bone marrow cancer 9.7 ITGB3 MPL SELP THPO VWF
42 bernard-soulier syndrome 9.7 GP1BA ITGA2 ITGA2B ITGB3 THPO VWF
43 thrombocytopenia 9.7 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 MPL
44 von willebrand disease, type 2 9.7 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 VWF
45 thrombasthenia 9.6 GP1BA ITGA2 ITGA2B ITGB3 SELP
46 von willebrand's disease 9.6 ADAMTS13 GP1BA SELP VWF
47 thrombosis 9.6 ADAMTS13 GP1BA SELP VWF
48 thrombocytopenic purpura, autoimmune 9.6 GP1BA ITGA2B ITGB3 MPL SELP THPO
49 vascular disease 9.6 GP1BA HP ITGB3 SELP VWF
50 thrombocytopenia due to platelet alloimmunization 9.5 FCGR2A ITGA2 ITGA2B ITGB3 MPL SELP

Graphical network of the top 20 diseases related to Autoimmune Disease of Blood:



Diseases related to Autoimmune Disease of Blood

Symptoms & Phenotypes for Autoimmune Disease of Blood

GenomeRNAi Phenotypes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD5 FCGR2A GP1BA ITGA2 ITGA2B THPO

MGI Mouse Phenotypes related to Autoimmune Disease of Blood:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 ADAMTS13 CD5 FCGR2A FOXG1 GP1BA HP
2 cellular MP:0005384 9.91 FOXG1 GP1BA HP ITGA2 ITGA2B ITGB3
3 homeostasis/metabolism MP:0005376 9.73 ADAMTS13 FOXG1 GP1BA HP ITGA2 ITGA2B
4 immune system MP:0005387 9.36 ADAMTS13 CD5 FCGR2A FOXG1 HP ITGA2B

Drugs & Therapeutics for Autoimmune Disease of Blood

Drugs for Autoimmune Disease of Blood (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
2
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
3
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
4 Antifungal Agents Phase 1, Phase 2
5 Anti-Bacterial Agents Phase 1, Phase 2
6 Antibiotics, Antitubercular Phase 1, Phase 2
7 Immunologic Factors Phase 1, Phase 2
8 Anti-Infective Agents Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sirolimus for Autoimmune Disease of Blood Cells Active, not recruiting NCT00392951 Phase 1, Phase 2 sirolimus

Search NIH Clinical Center for Autoimmune Disease of Blood

Genetic Tests for Autoimmune Disease of Blood

Anatomical Context for Autoimmune Disease of Blood

MalaCards organs/tissues related to Autoimmune Disease of Blood:

41
T Cells, Bone, Bone Marrow

Publications for Autoimmune Disease of Blood

Variations for Autoimmune Disease of Blood

Expression for Autoimmune Disease of Blood

Search GEO for disease gene expression data for Autoimmune Disease of Blood.

Pathways for Autoimmune Disease of Blood

Pathways related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 GP1BA GYPA ITGA2 ITGA2B ITGB3 MPL
2
Show member pathways
12.87 FCGR2A ITGA2 ITGA2B ITGB3 THPO
3
Show member pathways
12.03 ITGA2 ITGA2B ITGB3
4
Show member pathways
11.98 GP1BA ITGA2 ITGA2B ITGB3 VWF
5 11.96 FCGR2A ITGA2 ITGB3
6
Show member pathways
11.88 ITGA2B ITGB3 VWF
7
Show member pathways
11.83 ITGA2 ITGA2B ITGB3
8 11.82 FCGR2A GP1BA ITGA2 ITGA2B ITGB3 VWF
9 11.77 ITGA2 ITGA2B ITGB3
10 11.69 FCGR2A ITGA2 ITGA2B ITGB3
11
Show member pathways
11.62 GP1BA ITGA2B ITGB3 MPL THPO VWF
12 11.54 ITGA2 ITGA2B ITGB3 THPO
13 11.49 CD5 GP1BA GYPA ITGA2 ITGA2B ITGB3
14 11.46 ITGA2 ITGA2B ITGB3
15 11.46 ITGA2 ITGA2B ITGB3
16 11.39 FCGR2A ITGA2B ITGB3
17 11.38 ITGA2 ITGA2B ITGB3 VWF
18 11.35 GP1BA HP SELP
19 11.34 CD5 FCGR2A GP1BA GYPA ITGA2 ITGA2B
20 11.33 GYPA ITGA2B ITGB3
21 11.04 ITGA2B ITGB3
22 10.9 ITGA2B ITGB3
23 10.72 GP1BA ITGA2 VWF
24 10.54 GP1BA VWF

GO Terms for Autoimmune Disease of Blood

Cellular components related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 CD5 GP1BA ITGB3 MPL RHCE RHD
2 cell surface GO:0009986 9.63 ADAMTS13 GP1BA ITGA2 ITGA2B ITGB3 MPL
3 external side of plasma membrane GO:0009897 9.62 CD5 ITGA2 ITGA2B SELP
4 integrin complex GO:0008305 9.13 ITGA2 ITGA2B ITGB3
5 platelet alpha granule membrane GO:0031092 8.8 ITGA2B ITGB3 SELP
6 integral component of membrane GO:0016021 10.11 CD5 FCGR2A GP1BA GYPA ITGA2 ITGA2B

Biological processes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.93 GP1BA ITGA2 ITGA2B ITGB3 SELP VWF
2 cell proliferation GO:0008283 9.88 CD5 ITGA2 MPL THPO
3 extracellular matrix organization GO:0030198 9.81 ITGA2 ITGA2B ITGB3 VWF
4 platelet degranulation GO:0002576 9.73 ITGA2B ITGB3 SELP VWF
5 viral entry into host cell GO:0046718 9.72 GYPA ITGA2 ITGB3
6 platelet activation GO:0030168 9.71 ADAMTS13 GP1BA ITGB3 VWF
7 hemostasis GO:0007599 9.67 ADAMTS13 GP1BA VWF
8 cell-matrix adhesion GO:0007160 9.67 ADAMTS13 ITGA2 ITGA2B ITGB3
9 integrin-mediated signaling pathway GO:0007229 9.62 ADAMTS13 ITGA2 ITGA2B ITGB3
10 cell adhesion mediated by integrin GO:0033627 9.59 ITGA2 ITGB3
11 blood coagulation, intrinsic pathway GO:0007597 9.58 GP1BA VWF
12 mesodermal cell differentiation GO:0048333 9.57 ITGA2 ITGB3
13 response to amine GO:0014075 9.56 ADAMTS13 ITGA2
14 blood coagulation GO:0007596 9.55 ADAMTS13 GP1BA ITGA2 ITGB3 VWF
15 ammonium transmembrane transport GO:0072488 9.54 RHCE RHD
16 ammonium transport GO:0015696 9.52 RHCE RHD
17 thrombopoietin-mediated signaling pathway GO:0038163 9.48 MPL THPO
18 cell-substrate adhesion GO:0031589 9.43 ITGA2 ITGB3 VWF
19 positive regulation of leukocyte migration GO:0002687 9.13 ITGA2 ITGA2B SELP
20 platelet aggregation GO:0070527 8.92 GP1BA ITGA2B ITGB3 MPL

Molecular functions related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.43 GYPA ITGA2 ITGB3
2 ammonium transmembrane transporter activity GO:0008519 9.16 RHCE RHD
3 fibrinogen binding GO:0070051 8.96 ITGA2B ITGB3
4 integrin binding GO:0005178 8.92 ADAMTS13 ITGA2 ITGB3 VWF

Sources for Autoimmune Disease of Blood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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