MCID: ATM012
MIFTS: 26

Autoimmune Disease of Blood

Categories: Blood diseases, Immune diseases
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Aliases & Classifications for Autoimmune Disease of Blood

MalaCards integrated aliases for Autoimmune Disease of Blood:

Name: Autoimmune Disease of Blood 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060050

Summaries for Autoimmune Disease of Blood

Disease Ontology: 11 An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.

MalaCards based summary: Autoimmune Disease of Blood is related to anemia, autoimmune hemolytic and acquired tear duct stenosis. An important gene associated with Autoimmune Disease of Blood is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include t cells, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Autoimmune Disease of Blood

Diseases related to Autoimmune Disease of Blood via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 887)
# Related Disease Score Top Affiliating Genes
1 anemia, autoimmune hemolytic 31.1 TNFSF13B LRBA IL6 ICOSLG HP CTLA4
2 acquired tear duct stenosis 10.5 PRTN3 MPO
3 stenosis of lacrimal passage 10.5 PRTN3 MPO
4 allergic cutaneous vasculitis 10.5 PRTN3 MPO
5 middle ear cholesterol granuloma 10.5 PRTN3 MPO
6 hilar lung neoplasm 10.5 CD8A CD4
7 bicipital tenosynovitis 10.5 PRTN3 CRP
8 clivus meningioma 10.5 PRTN3 MPO
9 laryngostenosis 10.5 PRTN3 MPO
10 orbital granuloma 10.5 PRTN3 MPO CRP
11 ethmoid sinusitis 10.4 PRTN3 MPO CRP
12 acute frontal sinusitis 10.4 PRTN3 MPO CRP
13 glossopharyngeal nerve disease 10.4 PRTN3 MPO CRP
14 erythema elevatum diutinum 10.4 PRTN3 MPO CRP
15 oral tuberculosis 10.4 CD8A CD4
16 pulmonary hemosiderosis 10.4 PRTN3 MPO CRP
17 early yaws 10.4 CD8A CD4
18 wissler-fanconi syndrome 10.4 PRTN3 CD8A CD4
19 arteritic anterior ischemic optic neuropathy 10.4 PRTN3 CRP
20 subacute bacterial endocarditis 10.4 PRTN3 MPO CRP
21 neuroretinitis 10.4 PRTN3 CRP CD4
22 syphilitic meningitis 10.4 CRP CD4
23 gastroduodenitis 10.4 CD8A CD4 CCR6
24 congenital hypogammaglobulinemia 10.4 CD4 CD19
25 sclerosing keratitis 10.4 PRTN3 CRP
26 thymic dysplasia 10.4 ICOSLG CD8A CD4
27 maxillary sinusitis 10.4 PRTN3 MPO CRP
28 spongiotic dermatitis 10.4 CD8A CD4 CCR6
29 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
30 autoimmune peripheral neuropathy 10.4 ICOSLG CD8A CD4
31 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
32 autoimmune cholangitis 10.4 CD8A CD4 CCR6
33 ventilation pneumonitis 10.4 CRP CD8A CD4
34 rapidly progressive glomerulonephritis 10.4 PRTN3 MPO CRP
35 achenbach syndrome 10.4 F3 CRP
36 autoimmune polyendocrine syndrome type 1 10.4 ICOSLG CD4 CCR6
37 lateral medullary syndrome 10.4 PRTN3 CRP
38 immunodeficiency 13 10.4 ICOSLG CD8A CD4
39 pernicious anemia 10.4 ICOSLG CD4 CCR6
40 panophthalmitis 10.4 CRP CD4
41 suppurative lymphadenitis 10.4 CRP CD8A CD4
42 encephalitozoonosis 10.4 CD8A CD4
43 palindromic rheumatism 10.4 PRTN3 CRP
44 dyskeratosis congenita, autosomal dominant 6 10.4 THPO MPL
45 immunodeficiency with hyper-igm, type 3 10.4 ICOSLG CD8A CD4
46 autoimmune cardiomyopathy 10.4 ICOSLG CTLA4 CD4
47 urinary schistosomiasis 10.4 IL5 ICOSLG CD4
48 anti-basement membrane glomerulonephritis 10.4 PRTN3 MPO CD4 CCR6
49 orbital plasma cell granuloma 10.4 PRTN3 CTLA4 CRP
50 egg allergy 10.4 IL5 CD4 CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of Blood:



Diseases related to Autoimmune Disease of Blood

Symptoms & Phenotypes for Autoimmune Disease of Blood

MGI Mouse Phenotypes related to Autoimmune Disease of Blood:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.19 ADAMTS13 CCR6 CD19 CD4 CRP CTLA4
2 immune system MP:0005387 9.96 ADAMTS13 CCR6 CD19 CD4 CD8A CRP
3 digestive/alimentary MP:0005381 9.76 CD19 CD4 CTLA4 IL5 IL6 ITGA2B
4 hematopoietic system MP:0005397 9.6 ADAMTS13 CCR6 CD19 CD4 CD8A CTLA4

Drugs & Therapeutics for Autoimmune Disease of Blood

Search Clinical Trials, NIH Clinical Center for Autoimmune Disease of Blood

Genetic Tests for Autoimmune Disease of Blood

Anatomical Context for Autoimmune Disease of Blood

Organs/tissues related to Autoimmune Disease of Blood:

MalaCards : T Cells

Publications for Autoimmune Disease of Blood

Variations for Autoimmune Disease of Blood

Expression for Autoimmune Disease of Blood

Search GEO for disease gene expression data for Autoimmune Disease of Blood.

Pathways for Autoimmune Disease of Blood

Pathways related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TNFSF13B TNF PRTN3 MPO IL6 IL5
2
Show member pathways
13.43 TNFSF13B TNF THPO MPL ITGA2B IL6
3
Show member pathways
13.27 TNFSF13B TNF THPO ITGA2B IL6 IL5
4
Show member pathways
13.17 CCR6 CD4 IL5 IL6 THPO TNF
5
Show member pathways
12.29 ICOSLG CTLA4 CD8A CD4
6 12.21 TNFSF13B TNF MPO MPL CTLA4 CD8A
7
Show member pathways
12.01 TNF IL5 CTLA4 CD8A CD4
8 11.69 PRTN3 MPO CD4
9
Show member pathways
11.64 CD4 CD8A CRP IL6
10 11.62 CCR6 CD4 CD8A IL5 TNF
11
Show member pathways
11.6 TNF IL5 CTLA4
12 11.56 TNF IL6 IL5
13 11.54 TNFSF13B TNF IL6
14 11.52 TNF IL6 CD8A CD4 CD19
15
Show member pathways
11.51 TNF IL6 IL5
16 11.39 TNF THPO MPO MPL ITGA2B IL6
17 11.28 ITGA2B F3 CD4
18 11.2 TNF IL6 ICOSLG CRP CD19
19 11.19 TNF IL6 IL5
20 11.17 TNF IL6 IL5 CD4
21 10.93 TNF IL6 CRP
22 10.87 TNFSF13B TNF THPO ITGA2B IL6 IL5
23
Show member pathways
10.25 TNF IL6

GO Terms for Autoimmune Disease of Blood

Cellular components related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.2 ADAMTS13 CRP F3 HP IL5 IL6
2 cell surface GO:0009986 10.07 TNF MPL ITGA2B F3 CD4 CCR6
3 extracellular region GO:0005576 10 ADAMTS13 CD8A CRP F3 HP IL5
4 external side of plasma membrane GO:0009897 9.6 TNF MPL ITGA2B ICOSLG F3 CTLA4

Biological processes related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.91 TNF MPO ICOSLG HP
2 acute-phase response GO:0006953 9.88 IL6 HP CRP
3 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.8 TNF IL6 IL5
4 immune system process GO:0002376 9.76 CD19 CD4 CD8A CTLA4 HP ICOSLG
5 thrombopoietin-mediated signaling pathway GO:0038163 9.73 THPO MPL
6 response to gold nanoparticle GO:1990268 9.56 TNF MPO
7 immune response GO:0006955 9.44 TNFSF13B TNF IL6 IL5 CTLA4 CD8A
8 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP

Molecular functions related to Autoimmune Disease of Blood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.65 TNFSF13B TNF THPO PRTN3 IL6 ICOSLG
2 cytokine activity GO:0005125 9.32 TNFSF13B TNF THPO IL6 IL5

Sources for Autoimmune Disease of Blood

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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