MCID: ATM013
MIFTS: 19

Autoimmune Disease of Cardiovascular System

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Cardiovascular System

MalaCards integrated aliases for Autoimmune Disease of Cardiovascular System:

Name: Autoimmune Disease of Cardiovascular System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060051

Summaries for Autoimmune Disease of Cardiovascular System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system.

MalaCards based summary : Autoimmune Disease of Cardiovascular System is related to autoimmune vasculitis and autoimmune cardiomyopathy. An important gene associated with Autoimmune Disease of Cardiovascular System is DNAJA2 (DnaJ Heat Shock Protein Family (Hsp40) Member A2), and among its related pathways/superpathways are Matrix Metalloproteinases and amb2 Integrin signaling. Affiliated tissues include t cells.

Related Diseases for Autoimmune Disease of Cardiovascular System

Diseases in the Cardiovascular System Disease family:

Autoimmune Disease of Cardiovascular System

Diseases related to Autoimmune Disease of Cardiovascular System via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 autoimmune vasculitis 31.4 CTSG DNAJA2 ELANE
2 autoimmune cardiomyopathy 31.4 ADRB1 LCK SYCP3
3 autoimmune atherosclerosis 11.1
4 vasculitis 10.0 CTSG ELANE
5 netherton syndrome 10.0 CTSG ELANE
6 gingivitis 9.9 CTSG ELANE
7 bronchiectasis 9.9 CTSG ELANE
8 granulomatosis with polyangiitis 9.9 CTSG ELANE
9 periodontal disease 9.6 CTSC ELANE
10 papillon-lefevre syndrome 9.5 CTSC CTSG ELANE

Graphical network of the top 20 diseases related to Autoimmune Disease of Cardiovascular System:



Diseases related to Autoimmune Disease of Cardiovascular System

Symptoms & Phenotypes for Autoimmune Disease of Cardiovascular System

Drugs & Therapeutics for Autoimmune Disease of Cardiovascular System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Cardiovascular System

Genetic Tests for Autoimmune Disease of Cardiovascular System

Anatomical Context for Autoimmune Disease of Cardiovascular System

MalaCards organs/tissues related to Autoimmune Disease of Cardiovascular System:

42
T Cells

Publications for Autoimmune Disease of Cardiovascular System

Variations for Autoimmune Disease of Cardiovascular System

Expression for Autoimmune Disease of Cardiovascular System

Search GEO for disease gene expression data for Autoimmune Disease of Cardiovascular System.

Pathways for Autoimmune Disease of Cardiovascular System

Pathways related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CTSG ELANE
2 10.84 ELANE LCK
3 10.52 ADRB1 LCK
4 9.1 ADRB1 LCK

GO Terms for Autoimmune Disease of Cardiovascular System

Cellular components related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 CTSC CTSG DNAJA2 ELANE LCK
2 secretory granule GO:0030141 9.26 CTSG ELANE
3 collagen-containing extracellular matrix GO:0062023 9.13 CTSC CTSG ELANE
4 azurophil granule lumen GO:0035578 8.8 CTSC CTSG ELANE

Biological processes related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.58 CTSC CTSG ELANE
2 extracellular matrix disassembly GO:0022617 9.37 CTSG ELANE
3 leukocyte migration GO:0050900 9.33 ELANE ESAM LCK
4 antimicrobial humoral response GO:0019730 9.32 CTSG ELANE
5 defense response to fungus GO:0050832 9.26 CTSG ELANE
6 negative regulation of growth of symbiont in host GO:0044130 8.96 CTSG ELANE
7 positive regulation of immune response GO:0050778 8.62 CTSG ELANE

Molecular functions related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.33 CTSC CTSG ELANE
2 chaperone binding GO:0051087 8.96 CTSC DNAJA2
3 serine-type endopeptidase activity GO:0004252 8.8 CTSC CTSG ELANE

Sources for Autoimmune Disease of Cardiovascular System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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