MCID: ATM013
MIFTS: 30

Autoimmune Disease of Cardiovascular System

Categories: Blood diseases, Cardiovascular diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Cardiovascular System

MalaCards integrated aliases for Autoimmune Disease of Cardiovascular System:

Name: Autoimmune Disease of Cardiovascular System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060051

Summaries for Autoimmune Disease of Cardiovascular System

Disease Ontology : 12 An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system.

MalaCards based summary : Autoimmune Disease of Cardiovascular System is related to autoimmune atherosclerosis and autoimmune vasculitis. An important gene associated with Autoimmune Disease of Cardiovascular System is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include heart, bone and skin, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Autoimmune Disease of Cardiovascular System

Diseases in the Cardiovascular System Disease family:

Autoimmune Disease of Cardiovascular System

Diseases related to Autoimmune Disease of Cardiovascular System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 881)
# Related Disease Score Top Affiliating Genes
1 autoimmune atherosclerosis 32.4 CD4 APOH
2 autoimmune vasculitis 32.0 TNF PRTN3 IL6 IL1B CRP CD4
3 autoimmune cardiomyopathy 11.2
4 autoimmune myocarditis 11.2
5 orbital osteomyelitis 10.5 F2 CRP
6 small intestine diverticulitis 10.5 F2 CRP
7 external pathological resorption 10.5 TNF IL6
8 spinal cord infarction 10.5 SERPINC1 F2 APOH
9 achenbach syndrome 10.5 F3 F2 CRP
10 livedoid vasculitis 10.5 SERPINC1 F2 APOH
11 eclampsia 10.5 TNF SERPINC1 F2
12 scorpion envenomation 10.5 TNF IL6
13 renal pelvis squamous cell carcinoma 10.5 F3 F2 CRP
14 prothrombin deficiency, congenital 10.5 SERPINC1 F2 APOH
15 synovial angioma 10.5 F3 F2 CRP
16 hematocele of tunica vaginalis testis 10.5 F2 CRP
17 emphysematous cholecystitis 10.5 F3 F2 CRP
18 purulent acute otitis media 10.5 PRTN3 CRP
19 lateral sinus thrombosis 10.5 SERPINC1 F2
20 papillary adenofibroma 10.5 F3 F2
21 femoral neuropathy 10.5 F3 F2
22 giant hemangioma 10.5 SERPINC1 F3 F2
23 dic in newborn 10.5 SERPINC1 F3 F2
24 abducens nerve disease 10.5 SERPINC1 F2 CRP
25 blue toe syndrome 10.5 SERPINC1 CRP
26 lemierre's syndrome 10.5 F3 F2 CRP
27 acute cor pulmonale 10.5 F3 F2 CRP
28 cerebral arteritis 10.5 SERPINC1 CRP
29 heparin-induced thrombocytopenia 10.5 SERPINC1 F3
30 hemopericardium 10.5 F3 F2 CRP
31 waterhouse-friderichsen syndrome 10.5 SERPINC1 F3 F2
32 toxic megacolon 10.5 TNF CRP CCR6
33 prothrombin deficiency 10.5 SERPINC1 F3 F2
34 active peptic ulcer disease 10.5 F3 F2 CRP
35 intracranial hypotension 10.5 SERPINC1 F3 F2
36 cold agglutinin disease 10.5 IL6 CRP
37 suppurative lymphadenitis 10.5 CRP CD4 CCR6
38 sagittal sinus thrombosis 10.5 SERPINC1 F3 F2
39 hepatic coma 10.5 SERPINC1 F3 F2
40 critical illness polyneuropathy 10.5 TNF F3 CRP
41 mikulicz disease 10.5 CRP CD4 CCR6
42 hemopneumothorax 10.5 F3 F2
43 igg4-related disease 10.5 ICOSLG CRP CCR6
44 pituitary adenoma 5, multiple types 10.5 SERPINC1 F3 F2
45 alpha-2-plasmin inhibitor deficiency 10.5 SERPINC1 F3 F2
46 sneddon syndrome 10.5 SERPINC1 F2 APOH
47 parametritis 10.5 F3 F2 CRP
48 idiopathic anterior uveitis 10.5 TNF IL6
49 splenic abscess 10.5 F2 CRP CD4
50 acute cholangitis 10.5 IL6 F2 CRP

Graphical network of the top 20 diseases related to Autoimmune Disease of Cardiovascular System:



Diseases related to Autoimmune Disease of Cardiovascular System

Symptoms & Phenotypes for Autoimmune Disease of Cardiovascular System

MGI Mouse Phenotypes related to Autoimmune Disease of Cardiovascular System:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 APOH CCR6 CD4 CRP F2 F3
2 immune system MP:0005387 9.77 CCR6 CD4 CRP F2 F3 IL17A
3 integument MP:0010771 9.32 CD4 F2 F3 IL17A IL1B IL6

Drugs & Therapeutics for Autoimmune Disease of Cardiovascular System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Cardiovascular System

Genetic Tests for Autoimmune Disease of Cardiovascular System

Anatomical Context for Autoimmune Disease of Cardiovascular System

MalaCards organs/tissues related to Autoimmune Disease of Cardiovascular System:

40
Heart, Bone, Skin, T Cells, Lung, Eye, Kidney

Publications for Autoimmune Disease of Cardiovascular System

Variations for Autoimmune Disease of Cardiovascular System

Expression for Autoimmune Disease of Cardiovascular System

Search GEO for disease gene expression data for Autoimmune Disease of Cardiovascular System.

Pathways for Autoimmune Disease of Cardiovascular System

Pathways related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF STING1 SERPINA3 PRTN3 MEFV IL6
2
Show member pathways
13.33 TNF PRTN3 IL6 IL1B IL17A HLA-B
3
Show member pathways
12.9 TNF STING1 IL6 IL1B HLA-B CD4
4 12.77 TNF STING1 IL6 IL1B HLA-B
5
Show member pathways
12.69 TNF IL6 IL1B IL17A ICOSLG HLA-B
6
Show member pathways
12.56 TNF IL6 IL1B IL17A CD4
7
Show member pathways
12.55 TNF IL6 IL1B IL17A CD4
8
Show member pathways
12.44 TNF IL6 IL1B IL17A F2 CD4
9 12.31 TNF IL6 HLA-B CD4
10
Show member pathways
12.3 TNF IL6 IL1B IL17A
11
Show member pathways
12.22 TNF IL6 IL1B IL17A HLA-B
12
Show member pathways
12.2 TNF IL6 IL1B F3
13
Show member pathways
12.14 SERPINC1 PRTN3 F3 F2
14 12.13 TNF STING1 MEFV IL6 IL1B
15
Show member pathways
12.13 TNF SERPINA3 IL6 IL1B F2 CRP
16 12.07 SERPINC1 F3 F2 CFHR2
17 11.93 TNF IL6 IL1B IL17A
18 11.9 TNF MEFV IL6 IL1B CD4
19 11.87 TNF IL6 IL1B F3
20 11.85 TNF IL6 IL1B CD4
21 11.82 TNF IL6 IL1B IL17A
22
Show member pathways
11.8 IL6 IL1B IL17A CD4
23 11.73 TNF IL6 IL1B
24 11.66 TNF IL6 IL1B CD4
25
Show member pathways
11.64 TNF IL6 IL1B
26 11.63 TNF IL6 IL1B
27 11.59 TNF IL6 IL1B
28 11.58 TNF IL6 ICOSLG CCR6
29 11.52 TNF IL6 IL1B
30 11.51 TNF IL6 IL1B
31 11.46 TNF IL6 IL1B
32 11.34 TNF IL6 IL1B
33 11.31 TNF IL6 IL1B
34 11.26 TNF IL1B IL17A CD4 CCR6
35 11.25 TNF IL6 IL1B
36 11.06 TNF IL6 IL1B IL17A
37 10.97 TNF IL6 CRP
38 10.92 TNF IL6 IL1B CD4
39
Show member pathways
10.9 TNF IL6 IL1B IL17A CD4

GO Terms for Autoimmune Disease of Cardiovascular System

Cellular components related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.02 SERPINC1 SERPINA3 PRTN3 MIR146A ICOSLG HLA-B
2 cell surface GO:0009986 9.8 TNF HLA-B F3 CD4 CCR6 APOH
3 external side of plasma membrane GO:0009897 9.73 TNF IL17A ICOSLG F2 CD4 CCR6
4 extracellular region GO:0005576 9.73 TNF SERPINC1 SERPINA3 PRTN3 IL6 IL1B
5 collagen-containing extracellular matrix GO:0062023 9.63 SERPINC1 SERPINA3 PRTN3 F3 F2 APOH
6 extracellular space GO:0005615 9.4 TNF SERPINC1 SERPINA3 PRTN3 MIR146A IL6

Biological processes related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.13 STING1 MEFV IL17A ICOSLG HLA-B CD4
2 positive regulation of gene expression GO:0010628 10.03 TNF MIR146A IL6 IL1B F3 CRP
3 positive regulation of protein phosphorylation GO:0001934 9.94 TNF IL1B F2 CD4
4 blood coagulation GO:0007596 9.93 SERPINC1 PRTN3 F3 F2
5 cellular response to lipopolysaccharide GO:0071222 9.91 TNF MIR146A IL6 IL1B
6 immune response GO:0006955 9.91 TNF IL6 IL1B IL17A HLA-B CD4
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 TNF STING1 IL6 IL1B
8 defense response to Gram-positive bacterium GO:0050830 9.84 TNF IL6 IL17A CRP
9 regulation of insulin secretion GO:0050796 9.83 TNF IL6 IL1B
10 cellular response to organic cyclic compound GO:0071407 9.82 TNF STING1 IL1B
11 positive regulation of T cell proliferation GO:0042102 9.82 IL6 IL1B CD4
12 humoral immune response GO:0006959 9.8 TNF IL6 CCR6
13 positive regulation of interleukin-1 beta production GO:0032731 9.8 TNF IL6 IL17A
14 positive regulation of interleukin-6 production GO:0032755 9.8 TNF IL6 IL1B IL17A
15 hemostasis GO:0007599 9.79 SERPINC1 F3 F2
16 negative regulation of endothelial cell proliferation GO:0001937 9.77 TNF MIR146A APOH
17 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.76 MIR146A MEFV F2
18 positive regulation of JAK-STAT cascade GO:0046427 9.74 TNF IL6 F2
19 positive regulation of interleukin-8 production GO:0032757 9.73 TNF IL6 IL1B F3
20 negative regulation of neurogenesis GO:0050768 9.7 TNF IL6 IL1B
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.69 TNF IL6 IL17A
22 regulation of establishment of endothelial barrier GO:1903140 9.67 TNF IL1B
23 negative regulation of fibrinolysis GO:0051918 9.66 F2 APOH
24 cytolysis by host of symbiont cells GO:0051838 9.66 F2 CFHR2
25 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
26 regulation of blood coagulation GO:0030193 9.63 SERPINC1 F2 APOH
27 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
28 sequestering of triglyceride GO:0030730 9.6 TNF IL1B
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IL1B
30 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
31 acute-phase response GO:0006953 9.56 SERPINA3 IL6 F2 CRP
32 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
33 inflammatory response GO:0006954 9.5 TNF SERPINA3 MEFV IL6 IL1B IL17A
34 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
35 cytokine-mediated signaling pathway GO:0019221 9.17 TNF PRTN3 IL6 IL1B IL17A F3

Molecular functions related to Autoimmune Disease of Cardiovascular System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF IL6 IL1B IL17A
2 signaling receptor binding GO:0005102 9.35 PRTN3 ICOSLG HLA-B F2 CD4
3 identical protein binding GO:0042802 9.28 TNF STING1 SERPINC1 MEFV ICOSLG CRP

Sources for Autoimmune Disease of Cardiovascular System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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