MCID: ATM007
MIFTS: 31

Autoimmune Disease of Central Nervous System

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Disease of Central Nervous System

MalaCards integrated aliases for Autoimmune Disease of Central Nervous System:

Name: Autoimmune Disease of Central Nervous System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060004

Summaries for Autoimmune Disease of Central Nervous System

Disease Ontology : 12 An autoimmune hypersensitivity disease located in the central nervous system.

MalaCards based summary : Autoimmune Disease of Central Nervous System is related to autoimmune neuropathy and neurosyphilis. An important gene associated with Autoimmune Disease of Central Nervous System is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and MicroRNAs in cancer. Affiliated tissues include central nervous system, bone and skin.

Related Diseases for Autoimmune Disease of Central Nervous System

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease Autoimmune Disease of the Nervous System
Infectious Disease of the Nervous System

Diseases related to Autoimmune Disease of Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 autoimmune neuropathy 11.2
2 neurosyphilis 10.6 IL17A IL10
3 dermatomyositis 10.6 MIR223 MIR155 MIR132
4 polyradiculoneuropathy 10.6 MBP IL17A IL10
5 schistosomiasis 10.6 TNF IL17A IL10
6 herpes simplex virus keratitis 10.6 IFNB1 CD4 CCR6
7 progressive relapsing multiple sclerosis 10.6 SERPINA3 IFNB1 H2AC18 CCR6
8 polyradiculopathy 10.6 MBP ICOSLG CD4
9 autoimmune optic neuritis 10.6 MOG MBP AQP4
10 mast cell neoplasm 10.6 U2AF1 SERPINA3 ICOSLG H2AC18
11 anogenital venereal wart 10.6 IFNB1 H2AC18 CD4 CCR6
12 balo concentric sclerosis 10.6 MOG MBP IFNB1 AQP4
13 immunodeficiency with hyper-igm, type 1 10.6 ICOSLG H2AC18 CD4 CCR6
14 esophageal candidiasis 10.6 IL17A CD4 CCR6
15 thymus gland disease 10.6 ICOSLG H2AC18 CD4 CCR6
16 internuclear ophthalmoplegia 10.6 MOG MBP IFNB1 AQP4
17 optic papillitis 10.6 MOG CD4 AQP4
18 thymus cancer 10.6 ICOSLG H2AC18 CD4 CCR6
19 mikulicz disease 10.6 IL10 CD4 CCR6
20 pre-malignant neoplasm 10.6 SERPINA3 MIR142 H2AC18 CCR6
21 cutaneous leishmaniasis 10.6 TNF IL17A IL10
22 blastomycosis 10.6 IL17A CD4 CCR6
23 legume allergy 10.6 IL10 ICOSLG CD4 CCR6
24 immunodeficiency 16 10.6 ICOSLG CD4 CCR6
25 fruit allergy 10.6 IL10 ICOSLG CD4 CCR6
26 autoimmune glomerulonephritis 10.6 ICOSLG CD4 CCR6
27 primary thrombocytopenia 10.6 IL10 ICOSLG CD4 CCR6
28 childhood type dermatomyositis 10.6 TNF ICOSLG CD4 CCR6
29 t cell deficiency 10.6 IL17A ICOSLG CD4 CCR6
30 inclusion body myositis 10.6 SERPINA3 MIR223 MIR155 ICOSLG
31 cardiovascular organ benign neoplasm 10.6 SERPINA3 MIR132 H2AC18 CCR6
32 blood protein disease 10.6 MIR126 ICOSLG H2AC18 CCR6
33 autoimmune cholangitis 10.6 IL17A CD4 CCR6
34 sialadenitis 10.6 TNF ICOSLG CD4 CCR6
35 evans' syndrome 10.6 MIR142 IL10 CD4 CCR6
36 immunodeficiency 35 10.6 IL10 ICOSLG CCR6
37 eye degenerative disease 10.6 U2AF1 SERPINA3 ICOSLG H2AC18 CCR6
38 gastrointestinal system benign neoplasm 10.6 SERPINA3 MIR142 H2AC18 CCR6
39 respiratory allergy 10.6 IL10 ICOSLG CD4 CCR6
40 pustulosis of palm and sole 10.6 TNF IL17A CCR6
41 arachnoiditis 10.6 TNF CD4 AQP4
42 leukemia, acute monocytic 10.6 U2AF1 TNF MIR155 H2AC18
43 scabies 10.6 IL10 CD4 CCR6
44 metal allergy 10.6 IL17A IL10 CD4
45 inflammatory bowel disease 18 10.6 IL17A IL10 CCR6
46 punctate inner choroidopathy 10.6 TNF IL10
47 retinal vasculitis 10.6 TNF IFNB1 CD4 CCR6
48 nasopharyngitis 10.6 TNF IL17A IFNB1 CCR6
49 cerebritis 10.6 TNF CD4 AQP4
50 myositis 10.6 TNF SERPINA3 IL17A ICOSLG

Graphical network of the top 20 diseases related to Autoimmune Disease of Central Nervous System:



Diseases related to Autoimmune Disease of Central Nervous System

Symptoms & Phenotypes for Autoimmune Disease of Central Nervous System

Drugs & Therapeutics for Autoimmune Disease of Central Nervous System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Central Nervous System

Genetic Tests for Autoimmune Disease of Central Nervous System

Anatomical Context for Autoimmune Disease of Central Nervous System

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Disease of Central Nervous System:

19
Central Nervous System

MalaCards organs/tissues related to Autoimmune Disease of Central Nervous System:

40
Bone, Skin, Heart, Lung, Spinal Cord, Eye, Thymus

Publications for Autoimmune Disease of Central Nervous System

Articles related to Autoimmune Disease of Central Nervous System:

(show all 12)
# Title Authors PMID Year
1
Effects of different exercise modalities on ataxia in multiple sclerosis patients: a randomized controlled study. 61
27794631 2017
2
A Novel Approach to Discriminate Subgroups in Multiple Sclerosis. 61
28129686 2016
3
Increased serum level of IL-37 in patients with multiple sclerosis and neuromyelitis optica. 61
26008726 2015
4
Multiple sclerosis and hyperprolactinemia: a case-control study. 61
25501283 2015
5
Anti-inflammatory effect of chymotrypsin to autoimmune response against CNS is dose-dependent. 61
25460085 2014
6
Infection of non-encapsulated species of Trichinella ameliorates experimental autoimmune encephalomyelitis involving suppression of Th17 and Th1 response. 61
20661746 2010
7
Interferon-beta up-regulates the expression of co-stimulatory molecules CD80, CD86 and CD40 on monocytes: significance for treatment of multiple sclerosis. 61
15544628 2004
8
[The role of the peripheral nervous system damage in clinical picture of multiple sclerosis]. 61
12938634 2003
9
[Experimental allergic encephalomyelitis as an animal model for multiple sclerosis]. 61
11488222 2001
10
Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis. 61
11205154 2000
11
Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. 61
7500044 1995
12
Dissociation of GFAP intermediate filaments in EAE: observations in the lumbar spinal cord. 61
2530171 1989

Variations for Autoimmune Disease of Central Nervous System

Expression for Autoimmune Disease of Central Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Central Nervous System.

Pathways for Autoimmune Disease of Central Nervous System

GO Terms for Autoimmune Disease of Central Nervous System

Cellular components related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 TNF SERPINA3 MIR223 MIR155 MIR142 MIR132
2 external side of plasma membrane GO:0009897 9.17 TNF MOG IL17A ICOSLG CD4 CCR6

Biological processes related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 TNF MBP IL17A IL10 CD4 CCR6
2 cytokine-mediated signaling pathway GO:0019221 9.83 TNF IL17A IL10 IFNB1 CD4
3 humoral immune response GO:0006959 9.71 TNF IFNB1 CCR6
4 gene silencing by miRNA GO:0035195 9.7 MIR9-1 MIR223 MIR155 MIR142 MIR132 MIR126
5 negative regulation of blood vessel endothelial cell migration GO:0043537 9.67 TNF MIR155 MIR132
6 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.65 MIR223 MIR124-1 IL10
7 negative regulation of interleukin-8 production GO:0032717 9.63 MIR155 MIR132 IL10
8 miRNA mediated inhibition of translation GO:0035278 9.62 MIR9-1 MIR155 MIR132 MIR124-1
9 positive regulation of microglial cell activation GO:1903980 9.6 MIR155 MIR142
10 negative regulation of microglial cell activation GO:1903979 9.59 MIR155 MIR124-1
11 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF MIR142
12 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.58 MBP IL10
13 positive regulation of sprouting angiogenesis GO:1903672 9.58 MIR155 MIR126 IL10
14 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.57 TNF MBP
15 negative regulation of vascular wound healing GO:0061044 9.56 TNF MIR155
16 negative regulation of interleukin-6 production GO:0032715 9.56 TNF MIR155 MIR132 IL10
17 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
18 negative regulation of cytokine production involved in immune response GO:0002719 9.52 TNF IL10
19 negative regulation of necrotic cell death GO:0060547 9.51 MIR223 MIR155
20 negative regulation of bicellular tight junction assembly GO:1903347 9.13 TNF MIR155 MIR142
21 negative regulation of inflammatory response GO:0050728 9.1 MIR223 MIR155 MIR142 MIR126 MIR124-1 IL10

Molecular functions related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF IL17A IL10 IFNB1
2 mRNA 3'-UTR binding GO:0003730 9.26 MIR9-1 MIR142 MIR126 MIR124-1
3 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR9-1 MIR223 MIR155 MIR142 MIR132 MIR126

Sources for Autoimmune Disease of Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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