MCID: ATM007
MIFTS: 38

Autoimmune Disease of Central Nervous System

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Autoimmune Disease of Central Nervous System

MalaCards integrated aliases for Autoimmune Disease of Central Nervous System:

Name: Autoimmune Disease of Central Nervous System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060004

Summaries for Autoimmune Disease of Central Nervous System

Disease Ontology : 12 An autoimmune hypersensitivity disease located in the central nervous system.

MalaCards based summary : Autoimmune Disease of Central Nervous System is related to palladium allergic contact dermatitis and cephalosporin allergy. An important gene associated with Autoimmune Disease of Central Nervous System is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lung, brain and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Disease of Central Nervous System

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease

Diseases related to Autoimmune Disease of Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
# Related Disease Score Top Affiliating Genes
1 palladium allergic contact dermatitis 10.6 IL10 IL17A
2 cephalosporin allergy 10.6 IFNG IL10
3 autoimmune atherosclerosis 10.6 FOXP3 IL10
4 multifocal choroiditis 10.6 IL10 TNF
5 punctate inner choroidopathy 10.6 IL10 TNF
6 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
7 exudative glomerulonephritis 10.6 IL1B TNF
8 acute necrotizing encephalitis 10.6 FOXP3 IFNG
9 retroperitoneal neuroblastoma 10.6 IFNB1 IL2
10 eye lymphoma 10.6 IL10 IL6
11 leukomalacia 10.6 IL6 TNF
12 scorpion envenomation 10.6 IL6 TNF
13 microscopic polyangiitis 10.6 HLA-DRB1 TNF
14 neuroretinitis 10.6 AQP4 IFNB1 MOG
15 juvenile myasthenia gravis 10.6 HLA-DRB1 IL10
16 oral tuberculosis 10.6 IL2 TNF
17 recurrent corneal erosion 10.6 IL1B IL6
18 variola major 10.6 IFNG IL2
19 bagassosis 10.6 IL1B IL6
20 autoimmune disease of peripheral nervous system 10.6 MBP MOG TNF
21 cranial nerve disease 10.6 AQP4 MBP MOG
22 mesial temporal lobe epilepsy with hippocampal sclerosis 10.6 HLA-DRB1 IL1B
23 fixed drug eruption 10.6 IFNG IL2
24 virus associated hemophagocytic syndrome 10.6 IL2 IL4
25 trichosporonosis 10.6 IFNG IL17A TNF
26 severe acute respiratory syndrome 10.6 IFNB1 IFNG TNF
27 spotted fever 10.6 IFNG IL10 TNF
28 respiratory allergy 10.5 IL10 IL17A IL4
29 hepatitis a 10.5 IFNG IL10 TNF
30 plasmodium falciparum malaria 10.5 IFNG IL10 TNF
31 spinal cord injury 10.5 AQP4 IL6 TNF
32 ige responsiveness, atopic 10.5 IFNG IL10 IL4
33 periventricular leukomalacia 10.5 IL6 MBP TNF
34 buruli ulcer 10.5 IFNG IL10 IL4
35 kawasaki disease 10.5 IL10 IL6 TNF
36 adult respiratory distress syndrome 10.5 IL10 IL6 TNF
37 nose disease 10.5 IL10 IL4 TNF
38 alcoholic hepatitis 10.5 IL10 IL6 TNF
39 ileitis 10.5 IL17A IL6 TNF
40 post-transplant lymphoproliferative disease 10.5 IL10 IL6 TNF
41 nickel allergic contact dermatitis 10.5 IFNG IL10 IL4
42 baylisascariasis 10.5 IFNG IL10 IL4
43 chronic graft versus host disease 10.5 IFNG IL10 TNF
44 pulmonary edema 10.5 IL10 IL1B TNF
45 scrub typhus 10.5 IL10 IL1B TNF
46 endocarditis 10.5 IL10 IL6 TNF
47 scleritis 10.5 IFNG IL4 TNF
48 intracranial hypertension 10.5 AQP4 IL1B TNF
49 apple allergy 10.5 FOXP3 IL10 IL4
50 spondylitis 10.5 IL17A IL6 TNF

Graphical network of the top 20 diseases related to Autoimmune Disease of Central Nervous System:



Diseases related to Autoimmune Disease of Central Nervous System

Symptoms & Phenotypes for Autoimmune Disease of Central Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Central Nervous System:

47 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.45 AQP4 CCR6 FOXP3 HLA-DRB5 IFNB1 IFNG
2 immune system MP:0005387 10.42 AQP4 CCR6 FOXP3 HLA-DRB5 IFNB1 IFNG
3 homeostasis/metabolism MP:0005376 10.39 AQP4 CCR6 FOXP3 IFNB1 IFNG IL10
4 growth/size/body region MP:0005378 10.35 AQP4 FOXP3 IFNG IL10 IL17A IL1B
5 behavior/neurological MP:0005386 10.32 AQP4 FOXP3 IFNG IL10 IL2 IL6
6 cellular MP:0005384 10.32 FOXP3 IFNG IL10 IL2 IL4 IL6
7 mortality/aging MP:0010768 10.27 AQP4 FOXP3 IFNG IL10 IL17A IL1B
8 nervous system MP:0003631 10.25 AQP4 CCR6 IFNB1 IFNG IL10 IL1B
9 digestive/alimentary MP:0005381 10.21 AQP4 FOXP3 IFNG IL10 IL17A IL2
10 endocrine/exocrine gland MP:0005379 10.2 AQP4 FOXP3 IFNG IL10 IL17A IL2
11 craniofacial MP:0005382 10.11 FOXP3 IFNG IL10 IL17A IL1B IL4
12 no phenotypic analysis MP:0003012 10.07 AQP4 FOXP3 IFNB1 IFNG IL10 IL17A
13 liver/biliary system MP:0005370 10.02 FOXP3 IFNG IL10 IL2 IL4 IL6
14 neoplasm MP:0002006 9.98 IFNB1 IFNG IL10 IL1B IL2 IL6
15 normal MP:0002873 9.97 CCR6 FOXP3 IFNB1 IFNG IL10 IL4
16 reproductive system MP:0005389 9.91 FOXP3 IFNG IL10 IL2 IL4 IL6
17 respiratory system MP:0005388 9.81 AQP4 FOXP3 IFNG IL10 IL17A IL2
18 skeleton MP:0005390 9.65 HLA-DRB5 IFNB1 IFNG IL10 IL17A IL1B
19 vision/eye MP:0005391 9.4 AQP4 FOXP3 IFNG IL10 IL2 IL4

Drugs & Therapeutics for Autoimmune Disease of Central Nervous System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Central Nervous System

Genetic Tests for Autoimmune Disease of Central Nervous System

Anatomical Context for Autoimmune Disease of Central Nervous System

MalaCards organs/tissues related to Autoimmune Disease of Central Nervous System:

42
Lung, Brain, T Cells, Eye, Spinal Cord, Bone, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Disease of Central Nervous System:

20
The Central Nervous System

Publications for Autoimmune Disease of Central Nervous System

Variations for Autoimmune Disease of Central Nervous System

Expression for Autoimmune Disease of Central Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Central Nervous System.

Pathways for Autoimmune Disease of Central Nervous System

Pathways related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CCR6 HLA-DRB1 HLA-DRB5 ICOSLG IFNB1 IFNG
2
Show member pathways
13.76 CCR6 IFNB1 IFNG IL10 IL17A IL1B
3
Show member pathways
13.62 IFNB1 IFNG IL10 IL17A IL1B IL2
4
Show member pathways
13.48 CCR6 IL10 IL17A IL1B IL2 IL4
5
Show member pathways
13.42 HLA-DRB1 HLA-DRB5 IFNB1 IFNG IL10 IL17A
6
Show member pathways
13.38 CCR6 IL10 IL17A IL1B IL2 IL4
7
Show member pathways
13.27 HLA-DRB1 HLA-DRB5 IFNG IL1B IL2 IL4
8
Show member pathways
13.19 IFNB1 IFNG IL10 IL1B IL2 IL6
9
Show member pathways
12.84 FOXP3 HLA-DRB1 HLA-DRB5 ICOSLG IFNG IL10
10
Show member pathways
12.81 IFNB1 IFNG IL1B IL6 TNF
11
Show member pathways
12.76 HLA-DRB1 HLA-DRB5 ICOSLG IFNG IL10 IL2
12
Show member pathways
12.73 IFNG IL10 IL17A IL1B IL2 IL6
13 12.69 FOXP3 IFNG IL10 IL17A IL1B IL2
14
Show member pathways
12.69 IFNG IL10 IL17A IL1B IL2 IL4
15
Show member pathways
12.6 IFNB1 IFNG IL2 IL4 TNF
16
Show member pathways
12.54 IFNB1 IFNG IL10 IL2 IL4 IL6
17
Show member pathways
12.48 IFNG IL1B IL2 IL4 IL6 TNF
18
Show member pathways
12.48 IFNG IL17A IL1B IL4 IL6 TNF
19 12.45 HLA-DRB1 HLA-DRB5 IL2 IL6 TNF
20
Show member pathways
12.43 HLA-DRB1 HLA-DRB5 ICOSLG IL2
21
Show member pathways
12.4 HLA-DRB1 HLA-DRB5 IFNG IL10 IL1B IL4
22
Show member pathways
12.37 IFNB1 IFNG IL10 IL17A IL1B IL2
23
Show member pathways
12.35 IFNG IL1B IL6 TNF
24
Show member pathways
12.34 IL10 IL1B IL2 IL6 TNF
25
Show member pathways
12.33 IFNB1 IFNG IL1B IL4 IL6 TNF
26 12.33 HLA-DRB1 HLA-DRB5 IFNB1 IFNG IL10 IL1B
27 12.32 AQP4 IL10 IL1B IL6 PLP1 TNF
28
Show member pathways
12.27 IFNB1 IFNG IL1B TNF
29
Show member pathways
12.23 FOXP3 HLA-DRB1 HLA-DRB5 IFNG IL10 IL17A
30
Show member pathways
12.22 IFNG IL10 IL17A IL1B IL2 IL4
31
Show member pathways
12.19 IFNG IL10 IL17A IL1B IL2 IL6
32
Show member pathways
12.18 IFNG IL1B IL4 IL6 TNF
33 12.15 IFNG IL10 IL2 IL4 IL6 TNF
34 12.13 IFNB1 IFNG IL1B TNF
35
Show member pathways
12.13 HLA-DRB1 IFNG IL1B IL2 IL4
36 12.12 IL10 IL17A IL1B IL4 IL6 S1PR1
37 12.06 IFNB1 IL1B IL6 TNF
38 12.06 HLA-DRB1 HLA-DRB5 IL1B IL4 IL6 TNF
39 12.05 AQP4 IFNG IL1B IL2 IL4 IL6
40 12.04 IFNB1 IFNG IL1B IL6
41 12.04 IFNG IL10 IL1B IL6 TNF
42 12.02 IFNB1 IFNG IL10 IL2 IL6
43 11.96 HLA-DRB1 HLA-DRB5 IFNG IL17A IL1B IL6
44 11.92 IFNG IL2 IL4 IL6
45
Show member pathways
11.92 FOXP3 IFNG IL2 IL4 TNF
46 11.88 IL10 IL1B IL6 TNF
47 11.86 IFNG IL1B IL6
48
Show member pathways
11.83 IFNG IL1B IL2 IL6 TNF
49 11.82 IFNB1 IFNG IL10 IL1B IL2 IL6
50 11.8 IL1B IL4 IL6 TNF

GO Terms for Autoimmune Disease of Central Nervous System

Cellular components related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 IFNB1 IFNG IL10 IL17A IL1B IL2
2 extracellular space GO:0005615 9.61 IFNB1 IFNG IL10 IL17A IL1B IL2
3 external side of plasma membrane GO:0009897 9.23 AQP4 CCR6 HLA-DRB1 ICOSLG IL17A MOG

Biological processes related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.99 IFNG IL1B IL2 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.99 IL10 IL1B IL6 TNF
3 MAPK cascade GO:0000165 9.98 IL1B IL2 MBP NEFL TNF
4 positive regulation of gene expression GO:0010628 9.98 FOXP3 IFNG IL1B IL4 IL6 PLP1
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL6 TNF
6 response to virus GO:0009615 9.91 FOXP3 IFNB1 IFNG TNF
7 B cell differentiation GO:0030183 9.9 IFNB1 IL10 IL4
8 interferon-gamma-mediated signaling pathway GO:0060333 9.89 HLA-DRB1 HLA-DRB5 IFNG
9 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
10 positive regulation of interleukin-6 production GO:0032755 9.88 IL1B IL6 TNF
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 IL6 S1PR1 TNF
12 T cell activation GO:0042110 9.86 FOXP3 ICOSLG IL4
13 T cell receptor signaling pathway GO:0050852 9.85 FOXP3 HLA-DRB1 HLA-DRB5 ICOSLG MOG
14 positive regulation of interferon-gamma production GO:0032729 9.84 IL1B IL2 TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 IFNG IL1B TNF
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IFNG IL2 IL4 IL6
17 negative regulation of T cell proliferation GO:0042130 9.82 FOXP3 HLA-DRB1 IL10
18 regulation of signaling receptor activity GO:0010469 9.81 IFNB1 IFNG IL10 IL17A IL1B IL2
19 negative regulation of interferon-gamma production GO:0032689 9.8 FOXP3 HLA-DRB1 IL10
20 negative regulation of interleukin-6 production GO:0032715 9.79 FOXP3 IL10 TNF
21 positive regulation of T cell proliferation GO:0042102 9.78 IL1B IL2 IL4 IL6
22 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
23 positive regulation of interleukin-6 secretion GO:2000778 9.77 IL17A IL1B MBP
24 positive regulation of osteoclast differentiation GO:0045672 9.75 IFNG IL17A TNF
25 negative regulation of interleukin-17 production GO:0032700 9.73 FOXP3 IFNG
26 positive regulation of immunoglobulin secretion GO:0051024 9.73 IL2 IL6
27 positive regulation of regulatory T cell differentiation GO:0045591 9.73 FOXP3 IL2
28 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B IL6 TNF
29 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL10 MBP
30 positive regulation of isotype switching to IgG isotypes GO:0048304 9.72 IL2 IL4
31 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG IL1B TNF
33 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
34 negative regulation of T-helper 17 cell differentiation GO:2000320 9.71 FOXP3 IL2
35 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
36 T cell migration GO:0072678 9.71 CCR6 S1PR1
37 regulation of regulatory T cell differentiation GO:0045589 9.71 FOXP3 IFNG IL2
38 positive regulation of MHC class II biosynthetic process GO:0045348 9.7 IL10 IL4
39 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
41 negative regulation of lymphocyte proliferation GO:0050672 9.69 FOXP3 IL2
42 response to glucocorticoid GO:0051384 9.69 IL10 IL6 TNF
43 axon ensheathment GO:0008366 9.68 MBP PLP1
44 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
45 positive regulation of interleukin-23 production GO:0032747 9.67 IFNG IL17A
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL10 IL1B TNF
47 regulation of isotype switching GO:0045191 9.65 IL10 IL4
48 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
49 type 2 immune response GO:0042092 9.65 IL10 IL4
50 humoral immune response GO:0006959 9.65 CCR6 IFNB1 IFNG IL6 TNF

Molecular functions related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 IFNB1 IFNG IL10 IL17A IL1B IL2
2 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL6
3 structural constituent of myelin sheath GO:0019911 9.16 MBP PLP1

Sources for Autoimmune Disease of Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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