MCID: ATM007
MIFTS: 39

Autoimmune Disease of Central Nervous System

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Autoimmune Disease of Central Nervous System

MalaCards integrated aliases for Autoimmune Disease of Central Nervous System:

Name: Autoimmune Disease of Central Nervous System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060004

Summaries for Autoimmune Disease of Central Nervous System

Disease Ontology : 12 An autoimmune hypersensitivity disease located in the central nervous system.

MalaCards based summary : Autoimmune Disease of Central Nervous System is related to palladium allergic contact dermatitis and cephalosporin allergy. An important gene associated with Autoimmune Disease of Central Nervous System is IFNB1 (Interferon Beta 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lung, brain and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Disease of Central Nervous System

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease Autoimmune Disease of the Nervous System

Diseases related to Autoimmune Disease of Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 palladium allergic contact dermatitis 10.4 IL10 IL17A
2 cephalosporin allergy 10.4 IFNG IL10
3 autoimmune atherosclerosis 10.4 FOXP3 IL10
4 multifocal choroiditis 10.4 IL10 TNF
5 punctate inner choroidopathy 10.4 IL10 TNF
6 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
7 retroperitoneal neuroblastoma 10.4 IFNB1 IL2
8 acute necrotizing encephalitis 10.4 FOXP3 IFNG
9 exudative glomerulonephritis 10.4 IL1B TNF
10 juvenile myasthenia gravis 10.4 HLA-DRB1 IL10
11 leukomalacia 10.4 IL6 TNF
12 scorpion envenomation 10.4 IL6 TNF
13 variola major 10.4 IFNG IL2
14 oral tuberculosis 10.4 IL2 TNF
15 recurrent corneal erosion 10.4 IL1B IL6
16 bagassosis 10.4 IL1B IL6
17 neuroretinitis 10.4 AQP4 IFNB1 MOG
18 mesial temporal lobe epilepsy with hippocampal sclerosis 10.4 HLA-DRB1 IL1B
19 autoimmune disease of peripheral nervous system 10.4 MBP MOG TNF
20 cranial nerve disease 10.4 AQP4 MBP MOG
21 fixed drug eruption 10.4 IFNG IL2
22 paraneoplastic syndromes 10.4 IL1B IL6
23 virus associated hemophagocytic syndrome 10.4 IL2 IL4
24 keratitis, hereditary 10.4 IL17A IL1B TLR9
25 severe acute respiratory syndrome 10.4 IFNB1 IFNG TNF
26 trichosporonosis 10.4 IFNG IL17A TNF
27 mucocutaneous leishmaniasis 10.4 IL10 TLR9 TNF
28 meningoencephalitis 10.4 IL6 MBP TLR9
29 irritable bowel syndrome 10.4 IL10 TLR9 TNF
30 myositis fibrosa 10.4 IFNG IL17A TLR9
31 spotted fever 10.4 IFNG IL10 TNF
32 filarial elephantiasis 10.4 IL10 IL4 TLR9
33 viral pneumonia 10.4 IL17A IL6 TLR9
34 dry eye syndrome 10.4 IL6 TLR9 TNF
35 hepatitis a 10.4 IFNG IL10 TNF
36 nasal cavity disease 10.4 IL10 IL4 TLR9
37 cryptococcosis 10.4 IFNG IL4 TLR9
38 vogt-koyanagi-harada disease 10.4 HLA-DRB1 IL10 IL17A
39 tungiasis 10.4 IL10 IL4 TNF
40 spinal cord injury 10.4 AQP4 IL6 TNF
41 reproductive system disease 10.4 IL6 TLR9 TNF
42 hypersensitivity reaction type iii disease 10.4 IL6 TLR9 TNF
43 periventricular leukomalacia 10.4 IL6 MBP TNF
44 female reproductive system disease 10.4 IL6 TLR9 TNF
45 gastrointestinal system cancer 10.4 IL6 TLR9 TNF
46 idiopathic interstitial pneumonia 10.3 IFNG IL4 TLR9
47 genital herpes 10.3 IL10 IL4 TLR9
48 ileitis 10.3 IL17A IL6 TNF
49 ige responsiveness, atopic 10.3 IFNG IL10 IL4
50 kawasaki disease 10.3 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Autoimmune Disease of Central Nervous System:



Diseases related to Autoimmune Disease of Central Nervous System

Symptoms & Phenotypes for Autoimmune Disease of Central Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Central Nervous System:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.45 AQP4 FOXP3 HLA-DRB5 IFNB1 IFNG IL10
2 immune system MP:0005387 10.42 AQP4 FOXP3 HLA-DRB5 IFNB1 IFNG IL10
3 homeostasis/metabolism MP:0005376 10.39 AQP4 FOXP3 IFNB1 IFNG IL10 IL17A
4 cellular MP:0005384 10.35 FOXP3 IFNG IL10 IL2 IL4 IL6
5 growth/size/body region MP:0005378 10.35 AQP4 FOXP3 IFNG IL10 IL17A IL1B
6 mortality/aging MP:0010768 10.3 AQP4 FOXP3 IFNG IL10 IL17A IL1B
7 digestive/alimentary MP:0005381 10.26 AQP4 FOXP3 IFNG IL10 IL17A IL2
8 endocrine/exocrine gland MP:0005379 10.2 AQP4 FOXP3 IFNG IL10 IL17A IL2
9 nervous system MP:0003631 10.18 AQP4 IFNB1 IFNG IL10 IL1B IL4
10 craniofacial MP:0005382 10.11 FOXP3 IFNG IL10 IL17A IL1B IL4
11 no phenotypic analysis MP:0003012 10.07 AQP4 FOXP3 IFNB1 IFNG IL10 IL17A
12 liver/biliary system MP:0005370 10.02 FOXP3 IFNG IL10 IL2 IL4 IL6
13 neoplasm MP:0002006 9.98 IFNB1 IFNG IL10 IL1B IL2 IL6
14 reproductive system MP:0005389 9.91 FOXP3 IFNG IL10 IL2 IL4 IL6
15 renal/urinary system MP:0005367 9.87 AQP4 FOXP3 IFNG IL17A IL4 IL6
16 respiratory system MP:0005388 9.81 AQP4 FOXP3 IFNG IL10 IL17A IL2
17 skeleton MP:0005390 9.65 HLA-DRB5 IFNB1 IFNG IL10 IL17A IL1B
18 vision/eye MP:0005391 9.4 AQP4 FOXP3 IFNG IL10 IL2 IL4

Drugs & Therapeutics for Autoimmune Disease of Central Nervous System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Central Nervous System

Genetic Tests for Autoimmune Disease of Central Nervous System

Anatomical Context for Autoimmune Disease of Central Nervous System

MalaCards organs/tissues related to Autoimmune Disease of Central Nervous System:

41
Lung, Brain, Bone, Heart, Eye, Thyroid, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Disease of Central Nervous System:

19
The Central Nervous System

Publications for Autoimmune Disease of Central Nervous System

Variations for Autoimmune Disease of Central Nervous System

Expression for Autoimmune Disease of Central Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Central Nervous System.

Pathways for Autoimmune Disease of Central Nervous System

Pathways related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 HLA-DRB1 HLA-DRB5 IFNB1 IFNG IL10 IL17A
2
Show member pathways
13.74 IFNB1 IFNG IL10 IL17A IL1B IL2
3
Show member pathways
13.62 IFNB1 IFNG IL10 IL17A IL1B IL2
4
Show member pathways
13.48 IL10 IL17A IL1B IL2 IL4 IL6
5
Show member pathways
13.47 HLA-DRB1 HLA-DRB5 IFNB1 IFNG IL10 IL17A
6
Show member pathways
13.36 IL10 IL17A IL1B IL2 IL4 IL6
7
Show member pathways
13.31 HLA-DRB1 HLA-DRB5 IFNG IL1B IL2 IL4
8
Show member pathways
13.14 IFNB1 IFNG IL10 IL1B IL2 IL6
9
Show member pathways
12.96 FOXP3 HLA-DRB1 HLA-DRB5 IFNG IL10 IL17A
10
Show member pathways
12.91 HLA-DRB1 HLA-DRB5 IFNB1 IFNG IL1B IL2
11
Show member pathways
12.82 IFNB1 IFNG IL1B IL6 TNF
12
Show member pathways
12.77 HLA-DRB1 HLA-DRB5 IFNG IL10 IL2 IL4
13
Show member pathways
12.76 IL1B IL2 IL6 TLR9 TNF
14
Show member pathways
12.73 IFNG IL10 IL17A IL1B IL2 IL6
15 12.7 FOXP3 IFNG IL10 IL17A IL1B IL2
16
Show member pathways
12.6 IFNB1 IFNG IL2 IL4 TNF
17
Show member pathways
12.59 IFNG IL10 IL17A IL1B IL2 IL4
18
Show member pathways
12.54 IFNB1 IFNG IL10 IL2 IL4 IL6
19 12.52 HLA-DRB1 HLA-DRB5 IL2 IL6 TNF
20
Show member pathways
12.48 IFNG IL1B IL2 IL4 IL6 TNF
21
Show member pathways
12.48 IFNG IL17A IL1B IL4 IL6 TNF
22
Show member pathways
12.42 HLA-DRB1 HLA-DRB5 IFNG IL10 IL1B IL4
23
Show member pathways
12.42 IFNB1 IFNG IL10 IL17A IL1B IL2
24 12.41 HLA-DRB1 HLA-DRB5 IFNB1 IL6 TNF
25
Show member pathways
12.36 IL10 IL1B IL2 IL6 TLR9 TNF
26
Show member pathways
12.35 IFNG IL1B IL6 TNF
27
Show member pathways
12.35 IFNB1 IFNG IL1B IL4 IL6 TLR9
28 12.33 AQP4 IL10 IL1B IL6 PLP1 TNF
29
Show member pathways
12.32 IFNB1 IL6 TLR9 TNF
30
Show member pathways
12.28 IFNB1 IFNG IL1B TNF
31 12.26 IFNG IL6 TLR9 TNF
32 12.23 HLA-DRB1 HLA-DRB5 IFNB1 IFNG IL10 IL1B
33
Show member pathways
12.23 FOXP3 HLA-DRB1 HLA-DRB5 IFNG IL10 IL17A
34
Show member pathways
12.22 IFNG IL10 IL17A IL1B IL2 IL4
35
Show member pathways
12.19 IFNG IL1B IL4 IL6 TNF
36 12.17 IL10 IL17A IL1B IL4 IL6 S1PR1
37 12.16 IFNG IL10 IL2 IL4 IL6 TNF
38 12.14 IFNB1 IFNG IL1B TNF
39
Show member pathways
12.13 HLA-DRB1 IFNG IL1B IL2 IL4
40
Show member pathways
12.12 IFNG IL10 IL17A IL1B IL2 IL6
41 12.08 HLA-DRB1 HLA-DRB5 IL1B IL4 IL6 TNF
42 12.06 IFNB1 IL1B IL6 TNF
43 12.05 AQP4 IFNG IL1B IL2 IL4 IL6
44 12.04 IFNB1 IFNG IL1B IL6
45 12.04 IFNG IL10 IL1B IL6 TNF
46 12.03 IFNB1 IFNG IL10 IL2 IL6
47 12.01 HLA-DRB1 HLA-DRB5 IFNG IL17A IL1B IL6
48
Show member pathways
11.93 FOXP3 IFNG IL2 IL4 TNF
49 11.92 IFNG IL2 IL4 IL6
50 11.9 IFNG IL10 IL17A IL1B IL2 IL4

GO Terms for Autoimmune Disease of Central Nervous System

Cellular components related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 IFNB1 IFNG IL10 IL17A IL1B IL2
2 extracellular region GO:0005576 9.7 CD52 IFNB1 IFNG IL10 IL17A IL1B
3 external side of plasma membrane GO:0009897 9.1 AQP4 HLA-DRB1 IL17A MOG S1PR1 TNF

Biological processes related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.98 IL1B IL6 TLR9 TNF
2 inflammatory response GO:0006954 9.98 IL10 IL17A IL1B IL6 PLP1 TLR9
3 T cell receptor signaling pathway GO:0050852 9.94 FOXP3 HLA-DRB1 HLA-DRB5 MOG
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL6 TNF
5 positive regulation of JNK cascade GO:0046330 9.92 IL1B TLR9 TNF
6 response to virus GO:0009615 9.92 FOXP3 IFNB1 IFNG TNF
7 positive regulation of gene expression GO:0010628 9.92 FOXP3 IFNG IL1B IL4 IL6 PLP1
8 positive regulation of inflammatory response GO:0050729 9.91 IL2 TLR9 TNF
9 B cell differentiation GO:0030183 9.91 IFNB1 IL10 IL4
10 interferon-gamma-mediated signaling pathway GO:0060333 9.9 HLA-DRB1 HLA-DRB5 IFNG
11 regulation of insulin secretion GO:0050796 9.9 IFNG IL1B TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.88 IL6 S1PR1 TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 IL1B TLR9 TNF
14 positive regulation of interferon-gamma production GO:0032729 9.86 IL1B IL2 TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IFNG IL1B TNF
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IFNG IL2 IL4 IL6
17 response to glucocorticoid GO:0051384 9.84 IL10 IL1B IL6 TNF
18 negative regulation of T cell proliferation GO:0042130 9.83 FOXP3 HLA-DRB1 IL10
19 positive regulation of JUN kinase activity GO:0043507 9.83 IL1B TLR9 TNF
20 positive regulation of B cell proliferation GO:0030890 9.83 IL2 IL4 TLR9
21 positive regulation of T cell proliferation GO:0042102 9.81 IL1B IL2 IL4 IL6
22 regulation of signaling receptor activity GO:0010469 9.81 IFNB1 IFNG IL10 IL17A IL1B IL2
23 negative regulation of interferon-gamma production GO:0032689 9.8 FOXP3 HLA-DRB1 IL10
24 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR9 TNF
25 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR9 TNF
26 negative regulation of neurogenesis GO:0050768 9.78 IL1B IL6 TNF
27 humoral immune response GO:0006959 9.78 IFNB1 IFNG IL6 TNF
28 positive regulation of interleukin-6 secretion GO:2000778 9.77 IL17A IL1B MBP
29 positive regulation of osteoclast differentiation GO:0045672 9.77 IFNG IL17A TNF
30 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR9 TNF
31 negative regulation of interleukin-17 production GO:0032700 9.75 FOXP3 IFNG
32 positive regulation of glial cell proliferation GO:0060252 9.75 IL1B IL6 TNF
33 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL6
34 positive regulation of regulatory T cell differentiation GO:0045591 9.74 FOXP3 IL2
35 response to molecule of bacterial origin GO:0002237 9.74 IL10 TLR9
36 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.74 IL10 MBP
37 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B TLR9
38 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IFNG IL1B TNF
39 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR9 TNF
40 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IL2 IL4
41 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
42 regulation of regulatory T cell differentiation GO:0045589 9.73 FOXP3 IFNG IL2
43 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
44 negative regulation of T-helper 17 cell differentiation GO:2000320 9.72 FOXP3 IL2
45 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
46 negative regulation of interleukin-8 production GO:0032717 9.72 IL10 TLR9
47 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 IL4
48 regulation of establishment of endothelial barrier GO:1903140 9.71 IL1B TNF
49 negative regulation of interleukin-6 production GO:0032715 9.71 FOXP3 IL10 TLR9 TNF
50 negative regulation of cytokine secretion involved in immune response GO:0002740 9.7 IL10 TNF

Molecular functions related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 IFNB1 IFNG IL10 IL17A IL1B IL2
2 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL6
3 structural constituent of myelin sheath GO:0019911 9.16 MBP PLP1

Sources for Autoimmune Disease of Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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