MCID: ATM014
MIFTS: 24

Autoimmune Disease of Endocrine System

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Endocrine System

MalaCards integrated aliases for Autoimmune Disease of Endocrine System:

Name: Autoimmune Disease of Endocrine System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060005

Summaries for Autoimmune Disease of Endocrine System

Disease Ontology : 12 An autoimmune disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.

MalaCards based summary : Autoimmune Disease of Endocrine System is related to autoimmune pancreatitis and autoimmune polyendocrine syndrome. An important gene associated with Autoimmune Disease of Endocrine System is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Autoimmune Disease of Endocrine System

Diseases in the Endocrine System Disease family:

Autoimmune Disease of Endocrine System

Diseases related to Autoimmune Disease of Endocrine System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 406)
# Related Disease Score Top Affiliating Genes
1 autoimmune pancreatitis 32.3 FOXP3 FCRL3 CTLA4 CD4
2 autoimmune polyendocrine syndrome 32.3 TPO TG INS FOXP3 CCR6 AIRE
3 graves' disease 32.1 TSHR TPO TG PTPN22 ICOSLG FCRL3
4 hashimoto thyroiditis 32.0 TSHR TPO TG PTPN22 PRSS3 FOXP3
5 hirata disease 11.2
6 polyendocrinopathy 10.6 FOXP3 AIRE
7 acute thyroiditis 10.6 TPO TG
8 mechanical strabismus 10.6 TPO TG
9 transient congenital hypothyroidism 10.5 TSHR TPO
10 iodine hypothyroidism 10.5 TSHR TPO TG
11 thyroid crisis 10.5 TSHR TPO TG
12 toxic diffuse goiter 10.5 TSHR TPO TG
13 cork-handlers' disease 10.5 CD8A CD4
14 necrotic uveal melanoma 10.5 CD8A CD4
15 endemic goiter 10.5 TSHR TPO TG
16 plummer's disease 10.5 TSHR TPO TG
17 nonencapsulated sclerosing carcinoma 10.5 TPO TG
18 aspirin allergy 10.5 TPO TG
19 adult acute lymphocytic leukemia 10.5 CD8A CD4 CCR6
20 dendritic cell thymoma 10.5 TG CD4 AIRE
21 early yaws 10.5 CD8A CD4
22 autoimmune peripheral neuropathy 10.5 ICOSLG CD4 AIRE
23 subacute thyroiditis 10.5 TSHR TPO TG
24 acute proliferative glomerulonephritis 10.5 ICOSLG CD4 CCR6
25 nail disorder, nonsyndromic congenital, 1 10.5 TG CCR6 AIRE
26 anal spasm 10.5 TG CD4 AIRE
27 chronic conjunctivitis 10.5 ICOSLG CD4 CCR6
28 postsurgical hypothyroidism 10.5 TPO TG
29 orbital plasma cell granuloma 10.5 TSHR CTLA4
30 hypotropia 10.5 TSHR TPO
31 ventilation pneumonitis 10.5 CD8A CD4
32 childhood type dermatomyositis 10.5 ICOSLG CD4 CCR6
33 wissler-fanconi syndrome 10.5 CD4 AIRE
34 sialadenitis 10.5 ICOSLG CD4 CCR6
35 hypersensitivity reaction type iii disease 10.5 ICOSLG CD4 CCR6
36 diffuse infiltrative lymphocytosis syndrome 10.5 CD8A CD4
37 exophthalmos 10.5 TSHR TPO TG
38 pneumonic tularemia 10.5 CD8A CD4 CCR6
39 tularemia 10.5 CD8A CD4 CCR6
40 scleral disease 10.5 CD8A CD4 CCR6
41 epithelial malignant thymoma 10.5 TG AIRE
42 athyreosis 10.5 TSHR TG
43 goodpasture syndrome 10.5 H2AC18 CD4 CCR6
44 immune-complex glomerulonephritis 10.5 ICOSLG H2AC18 CD4
45 chronic orbital inflammation 10.5 TSHR CTLA4
46 respiratory allergy 10.5 ICOSLG CD4 CCR6
47 iritis 10.5 CD8A CD4 CCR6
48 bacterial infectious disease 10.5 ICOSLG H2AC18 CD4 CCR6
49 parasitic ectoparasitic infectious disease 10.5 H2AC18 CD4 CCR6
50 latent syphilis 10.5 CD8A CD4

Graphical network of the top 20 diseases related to Autoimmune Disease of Endocrine System:



Diseases related to Autoimmune Disease of Endocrine System

Symptoms & Phenotypes for Autoimmune Disease of Endocrine System

MGI Mouse Phenotypes related to Autoimmune Disease of Endocrine System:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.9 AIRE CD4 CD8A CTLA4 FOXP3 INS
2 hematopoietic system MP:0005397 9.77 AIRE CCR6 CD4 CD8A CTLA4 FOXP3
3 immune system MP:0005387 9.44 AIRE CCR6 CD4 CD8A CTLA4 FOXP3

Drugs & Therapeutics for Autoimmune Disease of Endocrine System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Endocrine System

Genetic Tests for Autoimmune Disease of Endocrine System

Anatomical Context for Autoimmune Disease of Endocrine System

MalaCards organs/tissues related to Autoimmune Disease of Endocrine System:

40
T Cells

Publications for Autoimmune Disease of Endocrine System

Variations for Autoimmune Disease of Endocrine System

Expression for Autoimmune Disease of Endocrine System

Search GEO for disease gene expression data for Autoimmune Disease of Endocrine System.

Pathways for Autoimmune Disease of Endocrine System

Pathways related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.28 TNFRSF25 PTPN22 FOXP3 CTLA4 CD8A
2
Show member pathways
12.02 TSHR TPO TG INS ICOSLG FOXP3
3 11.88 ICOSLG CTLA4 CD8A CD4
4 11.51 CD8A CD4 CCR6
5 11.41 PTPN22 CTLA4 CD8A CD4
6 11.28 ICOSLG FOXP3 CTLA4 CCR6
7 11.08 CD8A CD4 AIRE
8 9.91 TSHR TPO TG

GO Terms for Autoimmune Disease of Endocrine System

Cellular components related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.35 ICOSLG CTLA4 CD8A CD4 CCR6
2 integral component of plasma membrane GO:0005887 9.23 TSHR TPO TNFRSF25 FCRL3 CTLA4 CD8A

Biological processes related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 CTLA4 CD8A CD4 CCR6 AIRE
2 cell surface receptor signaling pathway GO:0007166 9.55 TSHR TNFRSF25 FCRL3 CD8A CD4
3 negative regulation of immune response GO:0050777 9.43 FOXP3 CTLA4
4 negative regulation of interleukin-6 production GO:0032715 9.43 PTPN22 MIR125A FOXP3
5 hormone biosynthetic process GO:0042446 9.4 TPO TG
6 T cell mediated immunity GO:0002456 9.37 FOXP3 CD8A
7 T cell receptor signaling pathway GO:0050852 9.35 PTPN22 ICOSLG FOXP3 CTLA4 CD4
8 T cell activation GO:0042110 8.92 ICOSLG FOXP3 CD8A CD4

Molecular functions related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 TSHR TNFRSF25 CD4 CCR6
2 protein tyrosine kinase binding GO:1990782 8.8 PTPN22 FCRL3 CD4

Sources for Autoimmune Disease of Endocrine System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....