MCID: ATM014
MIFTS: 26

Autoimmune Disease of Endocrine System

Categories: Immune diseases

Aliases & Classifications for Autoimmune Disease of Endocrine System

MalaCards integrated aliases for Autoimmune Disease of Endocrine System:

Name: Autoimmune Disease of Endocrine System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060005

Summaries for Autoimmune Disease of Endocrine System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.

MalaCards based summary : Autoimmune Disease of Endocrine System is related to hirata disease and autoimmune pancreatitis. An important gene associated with Autoimmune Disease of Endocrine System is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and NF-kappaB Signaling. Affiliated tissues include t cells, bone and heart, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Related Diseases for Autoimmune Disease of Endocrine System

Diseases related to Autoimmune Disease of Endocrine System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 hirata disease 31.9 INS TNFRSF10A
2 autoimmune pancreatitis 31.9 CTLA4 FCRL3 FOXP3
3 graves' disease 30.8 ATP5PO CD40 CTLA4 FCRL3 IFNG PTPN22
4 hashimoto thyroiditis 30.8 AIRE ATP5PO CD40 CTLA4 IFNG PRSS3
5 autoimmune polyendocrine syndrome 11.1
6 subacute lymphocytic thyroiditis 10.3 TG TPO
7 hashimoto encephalopathy 10.3 TPO TSHR
8 familial thyroid dyshormonogenesis 10.3 TG TPO
9 benign struma ovarii 10.3 TG TSHR
10 struma ovarii 10.3 TG TSHR
11 autoimmune addison disease 10.3 AIRE CTLA4
12 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TG TPO
13 athyreosis 10.3 TG TSHR
14 type 1 diabetes mellitus 18 10.3 TNFRSF10A TNFRSF25
15 neonatal hypothyroidism 10.3 TG TPO TSHR
16 type 1 diabetes mellitus 12 10.3 CTLA4 INS
17 pernicious anemia 10.3 AIRE TG TPO
18 nodular goiter 10.3 TG TPO TSHR
19 multinodular goiter 10.2 TG TPO TSHR
20 follicular adenoma 10.2 TG TPO TSHR
21 type 1 diabetes mellitus 17 10.2 AIRE CTLA4 TNFRSF25
22 papillary carcinoma 10.2 TG TPO TSHR
23 differentiated thyroid carcinoma 10.2 TG TPO TSHR
24 adrenal cortical hypofunction 10.2 AIRE PTPN22 TNFRSF25
25 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2 AIRE CTLA4 PTPN22
26 dyshormonogenic goiter 10.2 SERPINA7 TG
27 hypothyroidism, congenital, nongoitrous, 2 10.2 SERPINA7 TG TSHR
28 heart block, congenital 10.2 DDX41 TNFRSF25
29 postsurgical hypothyroidism 10.2 TG TSHR
30 orbital plasma cell granuloma 10.2 CTLA4 TSHR
31 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2 AIRE PTPN22
32 type 1 diabetes mellitus 11 10.2 CTLA4 INS TNFRSF25
33 type 1 diabetes mellitus 2 10.2 INS PTPN22 TNFRSF25
34 hypothyroidism, congenital, nongoitrous, 4 10.2 SERPINA7 TG TPO
35 hyperthyroxinemia 10.2 SERPINA7 TPO TSHR
36 acute necrotizing encephalitis 10.2 FOXP3 IFNG
37 chronic mucocutaneous candidiasis 10.2 AIRE IFNG PTPN22
38 myxedema 10.2 CTLA4 TG TPO TSHR
39 caplan's syndrome 10.2 FOXP3 TNFRSF10A
40 myasthenia gravis 10.2 AIRE CTLA4 IFNG
41 thyroid cancer, nonmedullary, 2 10.2 TG TPO TSHR
42 hypoadrenocorticism, familial 10.2 AIRE CTLA4 PTPN22 TPO
43 temporal arteritis 10.2 IFNG PTPN22 TNFRSF10A
44 goiter 10.2 SERPINA7 TG TPO TSHR
45 bone inflammation disease 10.2 IFNG PTPN22 TNFRSF10A
46 endemic goiter 10.2 SERPINA7 TG TPO TSHR
47 nontoxic goiter 10.2 SERPINA7 TG TPO TSHR
48 subacute thyroiditis 10.2 SERPINA7 TG TPO TSHR
49 autoimmune polyendocrine syndrome, type ii 10.2 FCRL3 GPR174 INS
50 type 1 diabetes mellitus 13 10.1 CTLA4 INS

Graphical network of the top 20 diseases related to Autoimmune Disease of Endocrine System:



Diseases related to Autoimmune Disease of Endocrine System

Symptoms & Phenotypes for Autoimmune Disease of Endocrine System

MGI Mouse Phenotypes related to Autoimmune Disease of Endocrine System:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.93 AIRE CD40 CTLA4 FOXP3 IFNG INS
2 digestive/alimentary MP:0005381 9.8 AIRE CTLA4 FOXP3 IFNG INS PTPN22
3 hematopoietic system MP:0005397 9.77 AIRE CD40 CTLA4 FOXP3 GPR174 IFNG
4 immune system MP:0005387 9.44 AIRE CD40 CTLA4 FOXP3 GPR174 IFNG

Drugs & Therapeutics for Autoimmune Disease of Endocrine System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Endocrine System

Genetic Tests for Autoimmune Disease of Endocrine System

Anatomical Context for Autoimmune Disease of Endocrine System

MalaCards organs/tissues related to Autoimmune Disease of Endocrine System:

41
T Cells, Bone, Heart, Thyroid

Publications for Autoimmune Disease of Endocrine System

Variations for Autoimmune Disease of Endocrine System

Expression for Autoimmune Disease of Endocrine System

Search GEO for disease gene expression data for Autoimmune Disease of Endocrine System.

Pathways for Autoimmune Disease of Endocrine System

GO Terms for Autoimmune Disease of Endocrine System

Cellular components related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 CD40 FCRL3 TNFRSF10A TPO TSHR

Biological processes related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.56 IFNG TNFRSF10A TNFRSF25 TSHR
2 negative regulation of immune response GO:0050777 9.32 CTLA4 FOXP3
3 hormone biosynthetic process GO:0042446 9.16 TG TPO
4 negative regulation of interleukin-17 production GO:0032700 8.96 FOXP3 IFNG
5 regulation of regulatory T cell differentiation GO:0045589 8.8 CTLA4 FOXP3 IFNG

Molecular functions related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 8.96 FCRL3 PTPN22
2 signaling receptor activity GO:0038023 8.92 CD40 TNFRSF10A TNFRSF25 TSHR

Sources for Autoimmune Disease of Endocrine System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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