MCID: ATM014
MIFTS: 23

Autoimmune Disease of Endocrine System

Categories: Immune diseases

Aliases & Classifications for Autoimmune Disease of Endocrine System

MalaCards integrated aliases for Autoimmune Disease of Endocrine System:

Name: Autoimmune Disease of Endocrine System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060005

Summaries for Autoimmune Disease of Endocrine System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.

MalaCards based summary : Autoimmune Disease of Endocrine System is related to hirata disease and hashimoto thyroiditis. An important gene associated with Autoimmune Disease of Endocrine System is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Autoimmune Disease of Endocrine System

Diseases related to Autoimmune Disease of Endocrine System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 hirata disease 32.1 INS TNFRSF10A
2 hashimoto thyroiditis 30.8 AIRE ATP5PO CTLA4 IFNG PRSS3 PTPN22
3 graves' disease 30.8 ATP5PO CTLA4 FCRL3 IFNG PTPN22 SERPINA7
4 autoimmune pancreatitis 11.1
5 autoimmune polyendocrine syndrome 11.1
6 subacute lymphocytic thyroiditis 10.5 TG TPO
7 hashimoto encephalopathy 10.5 TPO TSHR
8 familial thyroid dyshormonogenesis 10.5 TG TPO
9 benign struma ovarii 10.5 TG TSHR
10 struma ovarii 10.4 TG TSHR
11 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.4 TG TPO
12 athyreosis 10.4 TG TSHR
13 autoimmune addison disease 10.4 AIRE CTLA4
14 type 1 diabetes mellitus 18 10.4 TNFRSF10A TNFRSF25
15 neonatal hypothyroidism 10.4 TG TPO TSHR
16 pernicious anemia 10.4 AIRE TG TPO
17 type 1 diabetes mellitus 12 10.4 CTLA4 INS
18 nodular goiter 10.4 TG TPO TSHR
19 multinodular goiter 10.4 TG TPO TSHR
20 follicular adenoma 10.4 TG TPO TSHR
21 type 1 diabetes mellitus 17 10.4 AIRE CTLA4 TNFRSF25
22 autoimmune polyendocrine syndrome, type ii 10.4 FCRL3 INS
23 papillary carcinoma 10.4 TG TPO TSHR
24 differentiated thyroid carcinoma 10.4 TG TPO TSHR
25 adrenal cortical hypofunction 10.4 AIRE PTPN22 TNFRSF25
26 postsurgical hypothyroidism 10.4 TG TSHR
27 vitiligo-associated multiple autoimmune disease susceptibility 6 10.4 AIRE PTPN22
28 heart block, congenital 10.4 DDX41 TNFRSF25
29 orbital plasma cell granuloma 10.3 CTLA4 TSHR
30 vitiligo-associated multiple autoimmune disease susceptibility 1 10.3 AIRE CTLA4 PTPN22
31 dyshormonogenic goiter 10.3 SERPINA7 TG
32 type 1 diabetes mellitus 11 10.3 CTLA4 INS TNFRSF25
33 type 1 diabetes mellitus 2 10.3 INS PTPN22 TNFRSF25
34 hypothyroidism, congenital, nongoitrous, 2 10.3 SERPINA7 TG TSHR
35 autoimmune disease of musculoskeletal system 10.3 DDX41 PTPN22 TNFRSF25
36 hypothyroidism, congenital, nongoitrous, 4 10.3 SERPINA7 TG TPO
37 hyperthyroxinemia 10.3 SERPINA7 TPO TSHR
38 chronic mucocutaneous candidiasis 10.3 AIRE IFNG PTPN22
39 myxedema 10.3 CTLA4 TG TPO TSHR
40 thyroid cancer, nonmedullary, 2 10.3 TG TPO TSHR
41 myasthenia gravis 10.3 AIRE CTLA4 IFNG
42 hypoadrenocorticism, familial 10.3 AIRE CTLA4 PTPN22 TPO
43 type 1 diabetes mellitus 13 10.3 CTLA4 INS
44 plummer's disease 10.2 TG TPO
45 temporal arteritis 10.2 IFNG PTPN22 TNFRSF10A
46 goiter 10.2 SERPINA7 TG TPO TSHR
47 mucinoses 10.2 IFNG INS
48 bone inflammation disease 10.2 IFNG PTPN22 TNFRSF10A
49 endemic goiter 10.2 SERPINA7 TG TPO TSHR
50 nontoxic goiter 10.2 SERPINA7 TG TPO TSHR

Graphical network of the top 20 diseases related to Autoimmune Disease of Endocrine System:



Diseases related to Autoimmune Disease of Endocrine System

Symptoms & Phenotypes for Autoimmune Disease of Endocrine System

MGI Mouse Phenotypes related to Autoimmune Disease of Endocrine System:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 AIRE CTLA4 IFNG INS PTPN22 TG
2 hematopoietic system MP:0005397 9.7 AIRE CCR6 CTLA4 IFNG INS PTPN22
3 immune system MP:0005387 9.36 AIRE CCR6 CTLA4 IFNG INS PTPN22

Drugs & Therapeutics for Autoimmune Disease of Endocrine System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Endocrine System

Genetic Tests for Autoimmune Disease of Endocrine System

Anatomical Context for Autoimmune Disease of Endocrine System

MalaCards organs/tissues related to Autoimmune Disease of Endocrine System:

42
T Cells

Publications for Autoimmune Disease of Endocrine System

Variations for Autoimmune Disease of Endocrine System

Expression for Autoimmune Disease of Endocrine System

Search GEO for disease gene expression data for Autoimmune Disease of Endocrine System.

Pathways for Autoimmune Disease of Endocrine System

GO Terms for Autoimmune Disease of Endocrine System

Cellular components related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 CCR6 FCRL3 TNFRSF10A TPO TSHR

Biological processes related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.46 IFNG TNFRSF10A TNFRSF25 TSHR
2 regulation of regulatory T cell differentiation GO:0045589 9.26 CTLA4 IFNG
3 hormone biosynthetic process GO:0042446 8.96 TG TPO
4 humoral immune response GO:0006959 8.8 AIRE CCR6 IFNG

Molecular functions related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 8.96 FCRL3 PTPN22
2 signaling receptor activity GO:0038023 8.92 CCR6 TNFRSF10A TNFRSF25 TSHR

Sources for Autoimmune Disease of Endocrine System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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