MCID: ATM014
MIFTS: 24

Autoimmune Disease of Endocrine System

Categories: Immune diseases

Aliases & Classifications for Autoimmune Disease of Endocrine System

MalaCards integrated aliases for Autoimmune Disease of Endocrine System:

Name: Autoimmune Disease of Endocrine System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060005

Summaries for Autoimmune Disease of Endocrine System

Disease Ontology : 12 A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.

MalaCards based summary : Autoimmune Disease of Endocrine System is related to graves' disease and hashimoto thyroiditis. An important gene associated with Autoimmune Disease of Endocrine System is TG (Thyroglobulin), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Autoimmune Disease of Endocrine System

Diseases related to Autoimmune Disease of Endocrine System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 graves' disease 28.2 AIRE ATP5PO CD40 CTLA4 FCRL3 IFNG
2 hashimoto thyroiditis 27.6 AIRE ATP5PO CD40 CTLA4 IFNG IL2
3 familial thyroid dyshormonogenesis 11.0 TG TPO
4 autoimmune polyendocrine syndrome 11.0
5 benign struma ovarii 10.9 TG TSHR
6 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.9 TG TPO
7 lymphoepithelioma-like thymic carcinoma 10.8 FOXP3 TG
8 neonatal hypothyroidism 10.8 TG TPO TSHR
9 athyreosis 10.8 TG TSHR
10 pernicious anemia 10.8 AIRE TG TPO
11 nodular goiter 10.8 TG TPO TSHR
12 type 1 diabetes mellitus 2 10.8 CTLA4 TNFRSF25
13 multinodular goiter 10.8 TG TPO TSHR
14 type 1 diabetes mellitus 17 10.8 AIRE CTLA4 TNFRSF25
15 follicular adenoma 10.8 TG TPO TSHR
16 autoimmune addison disease 10.7 AIRE CTLA4 PTPN22
17 type 1 diabetes mellitus 18 10.7 TNFRSF10A TNFRSF25
18 congenital hypothyroidism 10.7 TG TPO TSHR
19 autoimmune polyendocrine syndrome, type ii 10.7 AIRE GPR174
20 papillary carcinoma 10.7 TG TPO TSHR
21 differentiated thyroid carcinoma 10.7 TG TPO TSHR
22 adrenal cortical hypofunction 10.7 AIRE PTPN22 TNFRSF25
23 dyshormonogenic goiter 10.7 SERPINA7 TG
24 acute necrotizing encephalitis 10.7 FOXP3 IFNG
25 hypothyroidism, congenital, nongoitrous, 2 10.7 SERPINA7 TG TSHR
26 struma ovarii 10.7 TG TSHR
27 hyperthyroxinemia 10.7 SERPINA7 TPO TSHR
28 type 1 diabetes mellitus 11 10.6 CTLA4 TNFRSF25
29 heart block, congenital 10.6 DDX41 TNFRSF25
30 variola major 10.6 IFNG IL2
31 myxedema 10.6 CTLA4 TG TPO TSHR
32 subacute lymphocytic thyroiditis 10.6 IL2 TG TPO
33 autoimmune myocarditis 10.6 IFNG IL2
34 caplan's syndrome 10.6 FOXP3 TNFRSF10A
35 anterior uveitis 10.5 CTLA4 PTPN22
36 fixed drug eruption 10.5 IFNG IL2
37 hypoadrenocorticism, familial 10.5 AIRE CTLA4 PTPN22 TPO
38 autoimmune disease of gastrointestinal tract 10.5 CTLA4 TNFRSF10A TNFRSF25
39 vitiligo-associated multiple autoimmune disease susceptibility 1 10.5 AIRE CTLA4 PTPN22 TPO
40 berylliosis 10.5 IFNG IL2
41 endemic goiter 10.5 SERPINA7 TG TPO TSHR
42 graves disease 1 10.5 SERPINA7 TG TPO TSHR
43 nontoxic goiter 10.5 SERPINA7 TG TPO TSHR
44 subacute thyroiditis 10.5 SERPINA7 TG TPO TSHR
45 thyroid gland disease 10.5 SERPINA7 TG TPO TSHR
46 goiter 10.5 SERPINA7 TG TPO TSHR
47 chronic active epstein-barr virus infection 10.4 CTLA4 IFNG IL2
48 hematopoietic stem cell transplantation 10.4 CTLA4 IFNG IL2
49 omenn syndrome 10.4 AIRE FOXP3 IFNG
50 paracoccidioidomycosis 10.4 CTLA4 IFNG IL2

Graphical network of the top 20 diseases related to Autoimmune Disease of Endocrine System:



Diseases related to Autoimmune Disease of Endocrine System

Symptoms & Phenotypes for Autoimmune Disease of Endocrine System

MGI Mouse Phenotypes related to Autoimmune Disease of Endocrine System:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.93 TNFRSF25 TPO TSHR AIRE CD40 CTLA4
2 hematopoietic system MP:0005397 9.77 AIRE CD40 CTLA4 FOXP3 GPR174 IFNG
3 immune system MP:0005387 9.4 AIRE CD40 CTLA4 FOXP3 GPR174 IFNG

Drugs & Therapeutics for Autoimmune Disease of Endocrine System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Endocrine System

Genetic Tests for Autoimmune Disease of Endocrine System

Anatomical Context for Autoimmune Disease of Endocrine System

MalaCards organs/tissues related to Autoimmune Disease of Endocrine System:

41
T Cells

Publications for Autoimmune Disease of Endocrine System

Variations for Autoimmune Disease of Endocrine System

Expression for Autoimmune Disease of Endocrine System

Search GEO for disease gene expression data for Autoimmune Disease of Endocrine System.

Pathways for Autoimmune Disease of Endocrine System

GO Terms for Autoimmune Disease of Endocrine System

Cellular components related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 CD40 FCRL3 TNFRSF10A TPO TSHR

Biological processes related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.84 IFNG TNFRSF10A TNFRSF25 TSHR
2 response to lipopolysaccharide GO:0032496 9.71 CD40 PTPN22 TNFRSF10A TNFRSF25
3 apoptotic signaling pathway GO:0097190 9.69 CD40 TNFRSF10A TNFRSF25
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CD40 IFNG IL2
5 positive regulation of MAPK cascade GO:0043410 9.56 CD40 FCRL3 TNFRSF10A TNFRSF25
6 hormone biosynthetic process GO:0042446 9.52 TG TPO
7 immune response GO:0006955 9.5 AIRE CD40 CTLA4 IFNG IL2 TNFRSF10A
8 negative regulation of interleukin-17 production GO:0032700 9.49 FOXP3 IFNG
9 positive regulation of regulatory T cell differentiation GO:0045591 9.48 FOXP3 IL2
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.46 CD40 IL2
11 negative regulation of lymphocyte proliferation GO:0050672 9.37 FOXP3 IL2
12 positive regulation of B cell proliferation GO:0030890 9.33 CD40 FCRL3 IL2
13 negative regulation of T-helper 17 cell differentiation GO:2000320 9.32 FOXP3 IL2
14 regulation of regulatory T cell differentiation GO:0045589 8.92 CTLA4 FOXP3 IFNG IL2

Molecular functions related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 CD40 TNFRSF10A TNFRSF25 TSHR
2 protein tyrosine kinase binding GO:1990782 9.16 FCRL3 PTPN22
3 tumor necrosis factor-activated receptor activity GO:0005031 8.8 CD40 TNFRSF10A TNFRSF25

Sources for Autoimmune Disease of Endocrine System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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