MCID: ATM014
MIFTS: 26

Autoimmune Disease of Endocrine System

Categories: Immune diseases

Aliases & Classifications for Autoimmune Disease of Endocrine System

MalaCards integrated aliases for Autoimmune Disease of Endocrine System:

Name: Autoimmune Disease of Endocrine System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060005

Summaries for Autoimmune Disease of Endocrine System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.

MalaCards based summary : Autoimmune Disease of Endocrine System is related to hirata disease and autoimmune pancreatitis. An important gene associated with Autoimmune Disease of Endocrine System is TG (Thyroglobulin), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. Affiliated tissues include thyroid, t cells and bone, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Related Diseases for Autoimmune Disease of Endocrine System

Diseases related to Autoimmune Disease of Endocrine System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 hirata disease 32.2 INS TNFRSF10A
2 autoimmune pancreatitis 32.1 CTLA4 FCRL3 FOXP3
3 graves' disease 31.1 ATP5PO CTLA4 FCRL3 IFNG PTPN22 TG
4 hashimoto thyroiditis 30.8 AIRE ATP5PO CTLA4 IFNG PRSS3 PTPN22
5 autoimmune polyendocrine syndrome 11.1
6 subacute lymphocytic thyroiditis 10.5 TG TPO
7 hashimoto encephalopathy 10.5 TPO TSHR
8 familial thyroid dyshormonogenesis 10.5 TG TPO
9 benign struma ovarii 10.5 TG TSHR
10 struma ovarii 10.5 TG TSHR
11 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.4 TG TPO
12 athyreosis 10.4 TG TSHR
13 autoimmune addison disease 10.4 AIRE CTLA4
14 type 1 diabetes mellitus 18 10.4 TNFRSF10A TNFRSF25
15 goiter 10.4 TG TPO TSHR
16 endemic goiter 10.4 TG TPO TSHR
17 nontoxic goiter 10.4 TG TPO TSHR
18 subacute thyroiditis 10.4 TG TPO TSHR
19 pernicious anemia 10.4 AIRE TG TPO
20 nodular goiter 10.4 TG TPO TSHR
21 type 1 diabetes mellitus 12 10.4 CTLA4 INS
22 multinodular goiter 10.4 TG TPO TSHR
23 follicular adenoma 10.4 TG TPO TSHR
24 type 1 diabetes mellitus 17 10.4 AIRE CTLA4 TNFRSF25
25 papillary carcinoma 10.4 TG TPO TSHR
26 autoimmune polyendocrine syndrome, type ii 10.4 FCRL3 INS
27 differentiated thyroid carcinoma 10.4 TG TPO TSHR
28 adrenal cortical hypofunction 10.4 AIRE PTPN22 TNFRSF25
29 vitiligo-associated multiple autoimmune disease susceptibility 1 10.4 AIRE CTLA4 PTPN22
30 postsurgical hypothyroidism 10.4 TG TSHR
31 vitiligo-associated multiple autoimmune disease susceptibility 6 10.4 AIRE PTPN22
32 heart block, congenital 10.4 DDX41 TNFRSF25
33 orbital plasma cell granuloma 10.4 CTLA4 TSHR
34 acute necrotizing encephalitis 10.3 FOXP3 IFNG
35 type 1 diabetes mellitus 11 10.3 CTLA4 INS TNFRSF25
36 type 1 diabetes mellitus 2 10.3 INS PTPN22 TNFRSF25
37 caplan's syndrome 10.3 FOXP3 TNFRSF10A
38 congenital hypothyroidism 10.3 TG TPO TSHR
39 hypothyroidism, congenital, nongoitrous, 2 10.3 TG TSHR
40 chronic mucocutaneous candidiasis 10.3 AIRE IFNG PTPN22
41 toxic diffuse goiter 10.3 TG TNFRSF25 TPO TSHR
42 myxedema 10.3 CTLA4 TG TPO TSHR
43 thyroid cancer, nonmedullary, 2 10.3 TG TPO TSHR
44 graves disease 1 10.3 INS TG TPO TSHR
45 myasthenia gravis 10.3 AIRE CTLA4 IFNG
46 hypoadrenocorticism, familial 10.3 AIRE CTLA4 PTPN22 TPO
47 thyroid gland disease 10.3 INS TG TPO TSHR
48 temporal arteritis 10.3 IFNG PTPN22 TNFRSF10A
49 bone inflammation disease 10.3 IFNG PTPN22 TNFRSF10A
50 mucinoses 10.2 IFNG INS

Graphical network of the top 20 diseases related to Autoimmune Disease of Endocrine System:



Diseases related to Autoimmune Disease of Endocrine System

Symptoms & Phenotypes for Autoimmune Disease of Endocrine System

MGI Mouse Phenotypes related to Autoimmune Disease of Endocrine System:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.9 AIRE CTLA4 FOXP3 IFNG INS PTPN22
2 digestive/alimentary MP:0005381 9.8 AIRE CTLA4 FOXP3 IFNG INS PTPN22
3 hematopoietic system MP:0005397 9.73 AIRE CCR6 CTLA4 FOXP3 IFNG INS
4 immune system MP:0005387 9.4 AIRE CCR6 CTLA4 FOXP3 IFNG INS

Drugs & Therapeutics for Autoimmune Disease of Endocrine System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Endocrine System

Genetic Tests for Autoimmune Disease of Endocrine System

Anatomical Context for Autoimmune Disease of Endocrine System

MalaCards organs/tissues related to Autoimmune Disease of Endocrine System:

42
Thyroid, T Cells, Bone, Heart

Publications for Autoimmune Disease of Endocrine System

Variations for Autoimmune Disease of Endocrine System

Expression for Autoimmune Disease of Endocrine System

Search GEO for disease gene expression data for Autoimmune Disease of Endocrine System.

Pathways for Autoimmune Disease of Endocrine System

GO Terms for Autoimmune Disease of Endocrine System

Cellular components related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 CCR6 FCRL3 TNFRSF10A TPO TSHR

Biological processes related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.62 IFNG TNFRSF10A TNFRSF25 TSHR
2 T cell receptor signaling pathway GO:0050852 9.58 FOXP3 ICOSLG PTPN22
3 negative regulation of immune response GO:0050777 9.37 CTLA4 FOXP3
4 hormone biosynthetic process GO:0042446 9.26 TG TPO
5 negative regulation of interleukin-17 production GO:0032700 9.16 FOXP3 IFNG
6 humoral immune response GO:0006959 9.13 AIRE CCR6 IFNG
7 regulation of regulatory T cell differentiation GO:0045589 8.8 CTLA4 FOXP3 IFNG

Molecular functions related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 8.96 FCRL3 PTPN22
2 signaling receptor activity GO:0038023 8.92 CCR6 TNFRSF10A TNFRSF25 TSHR

Sources for Autoimmune Disease of Endocrine System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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