MCID: ATM014
MIFTS: 25

Autoimmune Disease of Endocrine System

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Endocrine System

MalaCards integrated aliases for Autoimmune Disease of Endocrine System:

Name: Autoimmune Disease of Endocrine System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060005

Summaries for Autoimmune Disease of Endocrine System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.

MalaCards based summary : Autoimmune Disease of Endocrine System is related to autoimmune polyendocrine syndrome and autoimmune pancreatitis. An important gene associated with Autoimmune Disease of Endocrine System is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are NF-kappaB Signaling and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Autoimmune Disease of Endocrine System

Diseases in the Endocrine System Disease family:

Autoimmune Disease of Endocrine System

Diseases related to Autoimmune Disease of Endocrine System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 444)
# Related Disease Score Top Affiliating Genes
1 autoimmune polyendocrine syndrome 32.6 TPO TG INS FOXP3 CCR6 AIRE
2 autoimmune pancreatitis 32.6 FOXP3 FCRL3 CTLA4 CD40LG CD4
3 graves' disease 32.4 TSHR TPO TG PTPN22 ICOSLG FCRL3
4 hashimoto thyroiditis 32.2 TSHR TPO TG PTPN22 PRSS3 MIR142
5 hirata disease 11.3
6 polyendocrinopathy 10.8 FOXP3 AIRE
7 acute thyroiditis 10.8 TPO TG
8 transient congenital hypothyroidism 10.7 TSHR TPO
9 hashimoto encephalopathy 10.7 TSHR TPO
10 cutaneous candidiasis 10.7 NUDT10 CCR6 AIRE
11 iodine hypothyroidism 10.7 TSHR TPO TG
12 thyroid crisis 10.7 TSHR TPO TG
13 toxic diffuse goiter 10.7 TSHR TPO TG
14 endemic goiter 10.7 TSHR TPO TG
15 plummer's disease 10.7 TSHR TPO TG
16 familial thyroid dyshormonogenesis 10.7 TPO TG
17 autoimmune addison disease 10.7 CTLA4 AIRE
18 adult acute lymphocytic leukemia 10.7 CD8A CD4 CCR6
19 dendritic cell thymoma 10.7 TG CD4 AIRE
20 chronic conjunctivitis 10.7 ICOSLG CD4 CCR6
21 subacute thyroiditis 10.7 TSHR TPO TG
22 hyperthyroxinemia 10.7 TSHR TPO TG
23 congenital rubella 10.7 TPO CD40LG
24 igg4-related disease 10.7 ICOSLG CD4 CCR6
25 hypothyroidism, congenital, nongoitrous, 2 10.7 TSHR TPO TG
26 wissler-fanconi syndrome 10.7 CD4 AIRE
27 type 1 diabetes mellitus 18 10.7 TNFRSF25 PTPN22
28 nonencapsulated sclerosing carcinoma 10.7 TPO TG
29 mechanical strabismus 10.7 TPO TG CD40LG
30 autoimmune retinopathy 10.7 CD40LG AIRE
31 postsurgical hypothyroidism 10.7 TPO TG
32 pneumonic tularemia 10.7 CD8A CD4 CCR6
33 ventilation pneumonitis 10.7 CD8A CD4
34 exophthalmos 10.7 TSHR TPO TG
35 athyreosis 10.7 TSHR TG
36 thyroid gland follicular carcinoma 10.7 TSHR TPO TG
37 bird fancier's lung 10.7 TNFRSF25 CD8A CD4
38 scleritis 10.7 PTPN22 CTLA4 CCR6
39 diffuse infiltrative lymphocytosis syndrome 10.7 CD8A CD4
40 nontoxic goiter 10.7 TSHR TPO TG ICOSLG
41 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.7 TPO TG
42 autoimmune lymphoproliferative syndrome, type iia 10.7 CD8A CD4
43 mucocutaneous leishmaniasis 10.7 H2AC18 CD8A CD4
44 american histoplasmosis 10.7 CD40LG CD4
45 syphilitic meningitis 10.7 CD40LG CD4
46 egg allergy 10.7 FOXP3 CD4 CCR6
47 skin sarcoidosis 10.7 CTLA4 CD8A CD4
48 diabetes mellitus, insulin-dependent, 20 10.7 TPO TG INS
49 mikulicz disease 10.7 CD40LG CD4 CCR6
50 anus cancer 10.7 H2AC18 CD8A CD4

Graphical network of the top 20 diseases related to Autoimmune Disease of Endocrine System:



Diseases related to Autoimmune Disease of Endocrine System

Symptoms & Phenotypes for Autoimmune Disease of Endocrine System

MGI Mouse Phenotypes related to Autoimmune Disease of Endocrine System:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.93 AIRE CD4 CD40LG CD8A CTLA4 FOXP3
2 hematopoietic system MP:0005397 9.8 AIRE CCR6 CD4 CD40LG CD8A CTLA4
3 immune system MP:0005387 9.44 AIRE CCR6 CD4 CD40LG CD8A CTLA4

Drugs & Therapeutics for Autoimmune Disease of Endocrine System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Endocrine System

Genetic Tests for Autoimmune Disease of Endocrine System

Anatomical Context for Autoimmune Disease of Endocrine System

MalaCards organs/tissues related to Autoimmune Disease of Endocrine System:

40
T Cells

Publications for Autoimmune Disease of Endocrine System

Variations for Autoimmune Disease of Endocrine System

Expression for Autoimmune Disease of Endocrine System

Search GEO for disease gene expression data for Autoimmune Disease of Endocrine System.

Pathways for Autoimmune Disease of Endocrine System

Pathways related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.31 TNFRSF25 PTPN22 FOXP3 CTLA4 CD8A CD40LG
2
Show member pathways
12.11 ICOSLG CTLA4 CD40LG CD4
3
Show member pathways
12.06 TSHR TPO TG INS ICOSLG FOXP3
4 11.82 ICOSLG CTLA4 CD8A CD40LG CD4
5 11.54 CD8A CD4 CCR6
6 11.52 PTPN22 CTLA4 CD8A CD4
7
Show member pathways
11.46 FOXP3 CTLA4 CD40LG
8 11.04 CD8A CD40LG CD4 AIRE
9 9.91 TSHR TPO TG

GO Terms for Autoimmune Disease of Endocrine System

Cellular components related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.63 TSHR TPO FCRL3 CD40LG CD4 CCR6
2 external side of plasma membrane GO:0009897 9.43 ICOSLG CTLA4 CD8A CD40LG CD4 CCR6
3 integral component of plasma membrane GO:0005887 9.28 TSHR TPO TNFRSF25 FCRL3 CTLA4 CD8A

Biological processes related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.65 TSHR TNFRSF25 FCRL3 CD8A CD4
2 immune response GO:0006955 9.63 CTLA4 CD8A CD40LG CD4 CCR6 AIRE
3 T cell costimulation GO:0031295 9.5 ICOSLG CTLA4 CD40LG
4 negative regulation of immune response GO:0050777 9.43 FOXP3 CTLA4
5 hormone biosynthetic process GO:0042446 9.4 TPO TG
6 T cell mediated immunity GO:0002456 9.37 FOXP3 CD8A
7 T cell receptor signaling pathway GO:0050852 9.35 PTPN22 ICOSLG FOXP3 CTLA4 CD4
8 T cell activation GO:0042110 8.92 ICOSLG FOXP3 CD8A CD4

Molecular functions related to Autoimmune Disease of Endocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 TSHR TNFRSF25 CD4 CCR6
2 protein tyrosine kinase binding GO:1990782 8.8 PTPN22 FCRL3 CD4

Sources for Autoimmune Disease of Endocrine System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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