MCID: ATM009
MIFTS: 26

Autoimmune Disease of Exocrine System

Categories: Immune diseases

Aliases & Classifications for Autoimmune Disease of Exocrine System

MalaCards integrated aliases for Autoimmune Disease of Exocrine System:

Name: Autoimmune Disease of Exocrine System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060029

Summaries for Autoimmune Disease of Exocrine System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the exocrine system.

MalaCards based summary : Autoimmune Disease of Exocrine System is related to suppurative uveitis and american histoplasmosis. An important gene associated with Autoimmune Disease of Exocrine System is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Disease of Exocrine System

Diseases related to Autoimmune Disease of Exocrine System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 594)
# Related Disease Score Top Affiliating Genes
1 suppurative uveitis 10.7 IL17A CD40LG
2 american histoplasmosis 10.7 CD40LG CD4
3 subacute cutaneous lupus erythematosus 10.6 TRIM21 TNF
4 autoimmune peripheral neuropathy 10.6 ICOSLG CD40LG CD4
5 uveoparotid fever 10.6 TNF CD8A
6 legume allergy 10.6 ICOSLG CD4 CCR6
7 fruit allergy 10.6 ICOSLG CD4 CCR6
8 external pathological resorption 10.6 TNF IL6
9 chancroid 10.6 CD40LG CD4 CCR6
10 autoimmune neuropathy 10.6 ICOSLG CD40LG CD4
11 ventilation pneumonitis 10.6 CD8A CD4
12 immunodeficiency with hyper-igm, type 2 10.6 ICOSLG H2AC18 CD40LG
13 tuberculoid leprosy 10.6 CD40LG CD4 CCR6
14 cork-handlers' disease 10.6 CD8A CD40LG CD4
15 scorpion envenomation 10.6 TNF IL6
16 selective immunoglobulin deficiency disease 10.6 ICOSLG CD8A CD40LG
17 submandibular gland disease 10.6 SSB HSPG2
18 dysgammaglobulinemia 10.6 ICOSLG CD8A CD40LG
19 early yaws 10.6 CD8A CD40LG CD4
20 pustulosis palmaris et plantaris 10.6 TNF CD40LG CCR6
21 autoimmune lymphoproliferative syndrome, type iia 10.6 CD8A CD4
22 endocardial fibroelastosis 10.6 TRIM21 SSB RO60
23 viral exanthem 10.6 CD8A CD40LG CD4
24 klebsiella pneumonia 10.6 IL17A CD40LG CCR6
25 west nile encephalitis 10.6 CD8A CD40LG CD4
26 secondary syphilis 10.6 CD8A CD40LG CD4
27 autoimmune vasculitis 10.6 TNF CD4 CCR6
28 opportunistic bacterial infectious disease 10.6 TNF CD40LG CD4
29 gastrointestinal tuberculosis 10.6 TNF CD40LG CD4
30 west nile fever 10.6 CD8A CD40LG CD4
31 granulomatous dermatitis 10.6 TNF CD40LG CD4
32 adenoid hypertrophy 10.6 CD8A CD40LG CD4
33 t-cell adult acute lymphocytic leukemia 10.6 CD8A CD4 CCR6
34 adult acute lymphocytic leukemia 10.6 CD8A CD4 CCR6
35 abdominal tuberculosis 10.6 TNF CD40LG CD4
36 granulomatous myositis 10.6 TRIM21 CD8A
37 syphilitic meningitis 10.6 CXCL13 CD40LG CD4
38 seborrheic dermatitis 10.6 TNF CD4 CCR6
39 transient arthritis 10.6 IL17A CD40LG CD4
40 diabetes mellitus, insulin-dependent, 23 10.6 TNF CD8A CD4
41 congenital toxoplasmosis 10.6 CD8A CD40LG CD4
42 subcutaneous mycosis 10.6 IL17A CD4 CCR6
43 idiopathic anterior uveitis 10.6 TNF IL6
44 asymptomatic neurosyphilis 10.6 CXCL13 CD40LG CD4
45 giardiasis 10.6 CD8A CD40LG CD4
46 latent syphilis 10.6 CXCL13 CD40LG CD4
47 dermatophytosis 10.6 IL17A CD4 CCR6
48 anus cancer 10.6 H2AC18 CD8A CD4
49 tertiary neurosyphilis 10.6 CXCL13 CD40LG CD4
50 interstitial nephritis 10.6 ICOSLG CD40LG CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of Exocrine System:



Diseases related to Autoimmune Disease of Exocrine System

Symptoms & Phenotypes for Autoimmune Disease of Exocrine System

MGI Mouse Phenotypes related to Autoimmune Disease of Exocrine System:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCR6 CD4 CD40LG CD8A CXCL13 CXCR5
2 immune system MP:0005387 9.83 CCR6 CD4 CD40LG CD8A CXCL13 CXCR5
3 integument MP:0010771 9.28 CD4 CD40LG CD8A HSPG2 IL17A IL6

Drugs & Therapeutics for Autoimmune Disease of Exocrine System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Exocrine System

Genetic Tests for Autoimmune Disease of Exocrine System

Anatomical Context for Autoimmune Disease of Exocrine System

MalaCards organs/tissues related to Autoimmune Disease of Exocrine System:

40
T Cells

Publications for Autoimmune Disease of Exocrine System

Variations for Autoimmune Disease of Exocrine System

Expression for Autoimmune Disease of Exocrine System

Search GEO for disease gene expression data for Autoimmune Disease of Exocrine System.

Pathways for Autoimmune Disease of Exocrine System

Pathways related to Autoimmune Disease of Exocrine System according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 TRIM21 TNFSF13B TNF SIGLEC5 IRF5 IL6
2
Show member pathways
13.76 TNFSF13B TNF IL6 IL17A HSPG2 CXCR5
3
Show member pathways
13.6 TNFSF13B TNF IL6 IL17A IFNA1 CXCR5
4
Show member pathways
13.26 TNFSF13B TNF IL6 IL17A CXCR5 CXCL13
5
Show member pathways
13.13 TRIM21 TNFSF13B TNF IRF5 IL6 IL17A
6
Show member pathways
12.98 TNFSF13B TNF IL6 IL17A CXCR5 CXCL13
7
Show member pathways
12.42 TNF IL6 IL17A CD8A CD40LG CD4
8 12.27 TNFSF13B TNF IRF5 IL17A IFNA1 CXCR5
9
Show member pathways
12.23 TNF IL6 CXCR5 CXCL13 CCR6
10
Show member pathways
12.22 TNF IRF5 IL6 IL17A IFNA1
11
Show member pathways
12.11 TNFSF13B TNF IL6 IL17A IFNA1 ICOSLG
12 12.08 ICOSLG CD8A CD40LG CD4
13 11.94 TNF IL6 CD8A CD4
14
Show member pathways
11.87 TNF IL6 IL17A CD4
15 11.83 TNF IL6 CD8A CD4
16 11.79 TNFSF13B TNF IL6 IL17A
17
Show member pathways
11.77 IL6 IL17A CXCR5 CD4
18
Show member pathways
11.72 TNFSF13B TNF CD40LG
19
Show member pathways
11.67 TNFSF13B TNF CD40LG
20
Show member pathways
11.6 TNF IL6 CD40LG
21 11.6 TNF IL6 CD8A CD4
22 11.49 TNF IL6 CD40LG
23 11.35 CD8A CD40LG CD4
24 11.34 TNF IL17A CXCR5 CD8A CD4 CCR6
25 11.27 TNF IL6 IL17A
26 11.21 TNF IL6 CD4
27 10.77 TNFSF13B TNF IL6 IL17A HSPG2 CXCL13

GO Terms for Autoimmune Disease of Exocrine System

Cellular components related to Autoimmune Disease of Exocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNFSF13B TNF MIR155 IL6 IL17A IFNA1
2 external side of plasma membrane GO:0009897 9.23 TNF IL17A ICOSLG CXCR5 CD8A CD40LG

Biological processes related to Autoimmune Disease of Exocrine System according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.18 TNFSF13B IL6 IFNA1 ICOSLG CXCR5 CXCL13
2 regulation of immune response GO:0050776 9.89 TNFSF13B ICOSLG CD8A CD40LG
3 defense response to virus GO:0051607 9.86 MIR155 IRF5 IL6 IFNA1
4 inflammatory response GO:0006954 9.8 TNF IL6 IL17A HSPG2 CXCL13 CD40LG
5 chemokine-mediated signaling pathway GO:0070098 9.76 CXCR5 CXCL13 CCR6
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 TRIM21 TNF IL6 CD40LG
7 defense response GO:0006952 9.73 TNF IFNA1 ICOSLG CXCL13
8 T cell costimulation GO:0031295 9.71 TNFSF13B ICOSLG CD40LG
9 T cell activation GO:0042110 9.69 ICOSLG CD8A CD4
10 positive regulation of viral entry into host cell GO:0046598 9.61 TRIM21 CD4
11 negative regulation of lipid storage GO:0010888 9.6 TNF IL6
12 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.58 TNF IL17A
13 negative regulation of vascular wound healing GO:0061044 9.57 TNF MIR155
14 positive regulation of T cell proliferation GO:0042102 9.56 TNFSF13B IL6 CD40LG CD4
15 response to peptidoglycan GO:0032494 9.55 IRF5 IL6
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.54 TNF IL6 IL17A
17 negative regulation of bicellular tight junction assembly GO:1903347 9.49 TNF MIR155
18 regulation of immunoglobulin secretion GO:0051023 9.48 TNF CD40LG
19 humoral immune response GO:0006959 9.46 TNF IL6 IFNA1 CCR6
20 cytokine-mediated signaling pathway GO:0019221 9.43 TNF IRF5 IL6 IL17A IFNA1 CD4
21 immunoglobulin secretion GO:0048305 9.4 TNFSF13B CD40LG
22 immune response GO:0006955 9.32 TNFSF13B TNF IL6 IL17A CXCR5 CXCL13

Molecular functions related to Autoimmune Disease of Exocrine System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 TNFSF13B TNF IL6 IL17A IFNA1 CXCL13
2 tumor necrosis factor receptor binding GO:0005164 9.13 TNFSF13B TNF CD40LG

Sources for Autoimmune Disease of Exocrine System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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