MCID: ATM008
MIFTS: 35

Autoimmune Disease of Eyes, Ear, Nose and Throat

Categories: Ear diseases, Immune diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Autoimmune Disease of Eyes, Ear, Nose and Throat

MalaCards integrated aliases for Autoimmune Disease of Eyes, Ear, Nose and Throat:

Name: Autoimmune Disease of Eyes, Ear, Nose and Throat 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060030

Summaries for Autoimmune Disease of Eyes, Ear, Nose and Throat

Disease Ontology : 12 An autoimmune hypersensitivity disease located in eyes, located in ears, located in nose and located in throat.

MalaCards based summary : Autoimmune Disease of Eyes, Ear, Nose and Throat is related to autoimmune uveitis and chorioretinitis. An important gene associated with Autoimmune Disease of Eyes, Ear, Nose and Throat is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. Affiliated tissues include eye, lung and brain, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Autoimmune Disease of Eyes, Ear, Nose and Throat

Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 autoimmune uveitis 31.4 CAPN5 IL10 IL17A RBP3 RLBP1 SAG
2 chorioretinitis 10.3 RBP3 SAG
3 ocular toxoplasmosis 10.3 IL17A TLR9
4 autoimmune enteropathy 10.3 FOXP3 IL17A
5 palladium allergic contact dermatitis 10.3 IL10 IL17A
6 neurosyphilis 10.3 IL10 IL17A
7 autoimmune atherosclerosis 10.3 FOXP3 IL10
8 apple allergy 10.3 FOXP3 IL10
9 bardet-biedl syndrome 5 10.2 RHO SAG
10 pineocytoma 10.2 RHO SAG
11 acute zonal occult outer retinopathy 10.2 RLBP1 SAG
12 vulvovaginitis 10.2 CCL5 IL10
13 trichosporonosis 10.2 IL17A TNF
14 rheumatoid lung disease 10.2 IL17A TNF
15 adult dermatomyositis 10.2 TLR9 TNF
16 congenital stationary night blindness 10.2 RBP3 RHO SAG
17 tungiasis 10.2 IL10 TNF
18 cow milk allergy 10.2 IL10 TNF
19 trachoma 10.2 IL10 TNF
20 choroiditis 10.2 IL10 TNF
21 trichuriasis 10.1 IL10 TNF
22 clonorchiasis 10.1 IL10 TNF
23 transient hypogammaglobulinemia 10.1 IL10 TNF
24 chronic graft versus host disease 10.1 IL10 TNF
25 idiopathic achalasia 10.1 IL10 TNF
26 microscopic polyangiitis 10.1 IL10 TNF
27 multifocal choroiditis 10.1 IL10 TNF
28 autoimmune optic neuritis 10.1 FOXP3 IL10 IL17A
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 FOXP3 IL10 IL17A
30 respiratory allergy 10.1 IL10 IL17A TLR9
31 retinal disease 10.1 RHO RLBP1 SAG
32 retinal degeneration 10.1 RHO RLBP1 SAG
33 punctate inner choroidopathy 10.1 IL10 TNF
34 allergic hypersensitivity disease 10.1 CCL5 IL10 TLR9
35 tropical endomyocardial fibrosis 10.1 IL10 TNF
36 endomyocardial fibrosis 10.1 IL10 TNF
37 funisitis 10.1 IL10 IL6
38 acute transverse myelitis 10.1 IL10 IL6
39 melanoma-associated retinopathy 10.1 RHO SAG
40 genital herpes 10.1 CCL5 IL10 TLR9
41 crohn's disease 10.0 IL10 TLR9 TNF
42 rheumatic disease 10.0 IL10 TLR9 TNF
43 celiac disease 1 10.0 FOXP3 IL10 TNF
44 lichen disease 10.0 FOXP3 TLR9 TNF
45 primary systemic mycosis 10.0 IL10 IL17A TNF
46 mucocutaneous leishmaniasis 10.0 IL10 TLR9 TNF
47 coccidiosis 10.0 IL10 TLR9 TNF
48 obesity-hypoventilation syndrome 10.0 CCL5 IL6
49 reactive arthritis 10.0 IL10 IL17A TNF
50 nose disease 10.0 IL10 TLR9 TNF

Graphical network of the top 20 diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat:



Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat

Symptoms & Phenotypes for Autoimmune Disease of Eyes, Ear, Nose and Throat

MGI Mouse Phenotypes related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CCL5 FOXP3 IL10 IL17A IL6 NT5E
2 digestive/alimentary MP:0005381 9.73 FOXP3 IL10 IL17A IL6 TLR9 TNF
3 immune system MP:0005387 9.61 CAPN5 CCL5 FOXP3 IL10 IL17A IL6
4 vision/eye MP:0005391 9.28 CRYBB2 FOXP3 IL10 IL6 RBP3 RHO

Drugs & Therapeutics for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Eyes, Ear, Nose and Throat

Genetic Tests for Autoimmune Disease of Eyes, Ear, Nose and Throat

Anatomical Context for Autoimmune Disease of Eyes, Ear, Nose and Throat

MalaCards organs/tissues related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

41
Eye, Lung, Brain, Bone, Heart, Lymph Node, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

19
Eyes, Ears, Nose, Throat

Publications for Autoimmune Disease of Eyes, Ear, Nose and Throat

Variations for Autoimmune Disease of Eyes, Ear, Nose and Throat

Expression for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search GEO for disease gene expression data for Autoimmune Disease of Eyes, Ear, Nose and Throat.

Pathways for Autoimmune Disease of Eyes, Ear, Nose and Throat

Pathways related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CCL5 IL10 IL17A IL6 TLR9 TNF
2
Show member pathways
12.89 CCL5 IL10 IL6 TLR9 TNF
3
Show member pathways
12.77 FOXP3 IL10 IL17A IL6 TNF
4
Show member pathways
12.48 IL10 IL17A IL6 TNF
5
Show member pathways
12.48 FOXP3 IL10 IL17A IL6 TNF
6
Show member pathways
12.32 IL10 IL17A IL6 TNF
7
Show member pathways
12.22 RBP3 RHO RLBP1 SAG
8
Show member pathways
12.17 IL10 IL17A IL6 TNF
9 12.13 IL10 IL6 TLR9 TNF
10
Show member pathways
12.11 IL10 IL6 TLR9 TNF
11
Show member pathways
11.98 CCL5 IL10 IL17A IL6
12 11.9 IL10 IL6 TNF
13 11.86 CCL5 IL6 TNF
14 11.84 IL10 IL17A IL6 TNF
15 11.8 IL10 IL6 TNF
16
Show member pathways
11.78 FOXP3 IL17A IL6
17 11.77 RBP3 RHO RLBP1 SAG
18
Show member pathways
11.77 IL10 IL17A IL6 TLR9 TNF
19 11.71 CCL5 IL17A IL6 TNF
20 11.7 IL10 IL17A TNF
21 11.68 CCL5 FOXP3 IL10 IL17A NT5E TLR9
22 11.67 IL10 IL6 TNF
23 11.6 IL10 IL6 TLR9 TNF
24 11.57 CCL5 IL6 TNF
25
Show member pathways
11.5 RBP3 RHO RLBP1
26 11.36 CCL5 IL10 IL6 TNF
27 11.31 IL10 IL6 TLR9 TNF
28 11.28 IL10 IL6 TNF
29 11.22 IL17A IL6 TNF
30 11.2 CCL5 IL10 IL17A IL6 TNF
31 11.17 RBP3 RHO RLBP1 SAG
32 11.16 IL10 IL6 TNF
33 11.03 CCL5 IL10 IL17A IL6 TNF
34 11.01 IL6 TNF
35 11 IL10 IL6 TLR9 TNF
36 10.94 IL6 TNF
37 10.91 CCL5 IL10 IL17A IL6 TNF

GO Terms for Autoimmune Disease of Eyes, Ear, Nose and Throat

Biological processes related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 FOXP3 IL6 TLR9 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL6 TLR9 TNF
3 regulation of signaling receptor activity GO:0010469 9.8 CCL5 IL10 IL17A IL6 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.79 IL10 IL6 TNF
5 response to virus GO:0009615 9.79 CCL5 FOXP3 TNF
6 negative regulation of inflammatory response GO:0050728 9.78 FOXP3 IL10 NT5E
7 visual perception GO:0007601 9.73 CRYBB2 RBP3 RHO RLBP1
8 cytokine-mediated signaling pathway GO:0019221 9.72 CCL5 IL10 IL17A IL6 TNF
9 response to glucocorticoid GO:0051384 9.71 IL10 IL6 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.67 IL6 TLR9 TNF
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.65 CCL5 IL6 TNF
12 positive regulation of osteoclast differentiation GO:0045672 9.64 IL17A TNF
13 positive regulation of glial cell proliferation GO:0060252 9.63 IL6 TNF
14 negative regulation of growth of symbiont in host GO:0044130 9.63 IL10 TNF
15 retinoid metabolic process GO:0001523 9.63 RBP3 RHO RLBP1
16 immune response GO:0006955 9.63 CCL5 IL10 IL17A IL6 TLR9 TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 TNF
18 response to molecule of bacterial origin GO:0002237 9.6 IL10 TLR9
19 rhodopsin mediated signaling pathway GO:0016056 9.59 RHO SAG
20 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 TLR9 TNF
21 negative regulation of lipid storage GO:0010888 9.57 IL6 TNF
22 endothelial cell apoptotic process GO:0072577 9.56 IL10 TNF
23 negative regulation of interleukin-8 production GO:0032717 9.55 IL10 TLR9
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.52 IL10 TNF
25 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 TNF
26 positive regulation of chemokine production GO:0032722 9.43 IL6 TLR9 TNF
27 inflammatory response GO:0006954 9.43 CCL5 IL10 IL17A IL6 TLR9 TNF
28 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
29 negative regulation of interleukin-6 production GO:0032715 8.92 FOXP3 IL10 TLR9 TNF
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.06 FOXP3 IL10 IL17A IL6 TLR9 TNF

Molecular functions related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinol binding GO:0019841 9.26 RBP3 RLBP1
2 retinal binding GO:0016918 9.16 RBP3 RLBP1
3 cytokine activity GO:0005125 9.02 CCL5 IL10 IL17A IL6 TNF
4 11-cis retinal binding GO:0005502 8.96 RHO RLBP1

Sources for Autoimmune Disease of Eyes, Ear, Nose and Throat

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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