MCID: ATM008
MIFTS: 35

Autoimmune Disease of Eyes, Ear, Nose and Throat

Categories: Ear diseases, Immune diseases, Neuronal diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Autoimmune Disease of Eyes, Ear, Nose and Throat

MalaCards integrated aliases for Autoimmune Disease of Eyes, Ear, Nose and Throat:

Name: Autoimmune Disease of Eyes, Ear, Nose and Throat 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060030

Summaries for Autoimmune Disease of Eyes, Ear, Nose and Throat

Disease Ontology : 12 An autoimmune hypersensitivity disease located in eyes, located in ears, located in nose and located in throat.

MalaCards based summary : Autoimmune Disease of Eyes, Ear, Nose and Throat is related to autoimmune uveitis and chorioretinitis. An important gene associated with Autoimmune Disease of Eyes, Ear, Nose and Throat is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. Affiliated tissues include eye, lung and t cells, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Autoimmune Disease of Eyes, Ear, Nose and Throat

Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 autoimmune uveitis 30.4 CAPN5 IL10 IL17A IL2 RBP3 RLBP1
2 chorioretinitis 10.5 RBP3 SAG
3 apple allergy 10.4 FOXP3 IL10
4 acute zonal occult outer retinopathy 10.4 RLBP1 SAG
5 bardet-biedl syndrome 5 10.4 RHO SAG
6 pineocytoma 10.4 RHO SAG
7 palladium allergic contact dermatitis 10.3 IL10 IL17A
8 autoimmune atherosclerosis 10.3 FOXP3 IL10
9 cow milk allergy 10.3 IL10 TNF
10 trachoma 10.3 IL10 TNF
11 trichuriasis 10.3 IL10 TNF
12 mucocutaneous leishmaniasis 10.3 IL10 TNF
13 chronic graft versus host disease 10.3 IL10 TNF
14 idiopathic achalasia 10.3 IL10 TNF
15 viral pneumonia 10.3 IL17A IL6
16 melanoma-associated retinopathy 10.3 RHO SAG
17 punctate inner choroidopathy 10.2 IL10 TNF
18 funisitis 10.2 IL10 IL6
19 autoimmune optic neuritis 10.2 FOXP3 IL10 IL17A
20 congenital stationary night blindness 10.2 RBP3 RHO SAG
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 FOXP3 IL10 IL17A
22 tropical endomyocardial fibrosis 10.2 IL10 TNF
23 endomyocardial fibrosis 10.2 IL10 TNF
24 neurosyphilis 10.2 IL10 IL17A
25 retinal degeneration 10.2 RHO RLBP1 SAG
26 multifocal choroiditis 10.2 IL10 TNF
27 choroiditis 10.2 IL10 TNF
28 tungiasis 10.1 IL10 TNF
29 t-cell adult acute lymphocytic leukemia 10.1 FOXP3 IL2
30 gaucher disease, type ii 10.1 IL10 IL2
31 glossitis 10.1 IL6 TNF
32 laryngitis 10.1 IL6 TNF
33 acute vascular insufficiency of intestine 10.1 IL6 TNF
34 osteosclerotic myeloma 10.1 IL6 TNF
35 posterior urethral valves 10.1 IL6 TNF
36 trichosporonosis 10.1 IL17A TNF
37 primary systemic mycosis 10.1 IL10 IL17A TNF
38 opportunistic mycosis 10.1 IL10 IL17A TNF
39 reactive arthritis 10.1 IL10 IL17A TNF
40 eye lymphoma 10.1 IL10 IL6
41 allergic contact dermatitis 10.1 IL10 IL17A TNF
42 transient hypogammaglobulinemia 10.1 IL10 TNF
43 autoimmune enteropathy 10.1 FOXP3 IL17A
44 acute transverse myelitis 10.1 IL10 IL6
45 cutaneous leishmaniasis 10.1 FOXP3 IL10 TNF
46 cystic echinococcosis 10.1 IL10 IL17A IL6
47 radiculopathy 10.1 IL10 IL17A IL6
48 scorpion envenomation 10.1 IL6 TNF
49 demyelinating disease 10.0 IL10 IL17A TNF
50 omenn syndrome 10.0 FOXP3 IL10 TNF

Graphical network of the top 20 diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat:



Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat

Symptoms & Phenotypes for Autoimmune Disease of Eyes, Ear, Nose and Throat

MGI Mouse Phenotypes related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CCR6 FOXP3 IL10 IL17A IL2 IL6
2 cardiovascular system MP:0005385 10.06 FOXP3 IL10 IL2 IL6 NT5E RHO
3 hematopoietic system MP:0005397 10.06 CCR6 FOXP3 IL10 IL17A IL2 IL6
4 immune system MP:0005387 9.97 CAPN5 CCR6 FOXP3 IL10 IL17A IL2
5 digestive/alimentary MP:0005381 9.91 FOXP3 IL10 IL17A IL2 IL6 TNF
6 nervous system MP:0003631 9.91 CCR6 CRYBB2 IL10 IL6 RBP3 RHO
7 no phenotypic analysis MP:0003012 9.63 FOXP3 IL10 IL17A IL2 RHO TNF
8 respiratory system MP:0005388 9.43 FOXP3 IL10 IL17A IL2 IL6 TNF
9 vision/eye MP:0005391 9.32 CRYBB2 FOXP3 IL10 IL2 IL6 RBP3

Drugs & Therapeutics for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Eyes, Ear, Nose and Throat

Genetic Tests for Autoimmune Disease of Eyes, Ear, Nose and Throat

Anatomical Context for Autoimmune Disease of Eyes, Ear, Nose and Throat

MalaCards organs/tissues related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

42
Eye, Lung, T Cells, Bone, Heart, Lymph Node, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

20
Eyes, Ears, Nose, Throat

Publications for Autoimmune Disease of Eyes, Ear, Nose and Throat

Variations for Autoimmune Disease of Eyes, Ear, Nose and Throat

Expression for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search GEO for disease gene expression data for Autoimmune Disease of Eyes, Ear, Nose and Throat.

Pathways for Autoimmune Disease of Eyes, Ear, Nose and Throat

Pathways related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 CCR6 IL10 IL17A IL2 IL6 TNF
2
Show member pathways
13.2 CCR6 IL10 IL17A IL2 IL6 TNF
3
Show member pathways
12.75 FOXP3 IL10 IL17A IL2 IL6 TNF
4
Show member pathways
12.49 IL10 IL17A IL2 IL6 TNF
5
Show member pathways
12.39 IL10 IL17A IL2 IL6 TNF
6
Show member pathways
12.38 FOXP3 IL10 IL17A IL2 IL6 TNF
7 12.31 FOXP3 IL10 IL17A IL2 NT5E TNF
8
Show member pathways
12.26 RBP3 RHO RLBP1 SAG
9
Show member pathways
12.17 IL10 IL17A IL2 IL6 TNF
10
Show member pathways
12.13 IL10 IL2 IL6 TNF
11
Show member pathways
11.98 IL10 IL17A IL2 IL6
12 11.92 IL2 IL6 TNF
13 11.86 IL10 IL2 IL6 TNF
14 11.84 IL10 IL17A IL6 TNF
15 11.82 IL10 IL6 TNF
16
Show member pathways
11.8 FOXP3 IL17A IL6
17 11.79 IL10 IL2 IL6
18 11.79 IL17A IL6 TNF
19 11.78 RBP3 RHO RLBP1 SAG
20
Show member pathways
11.77 IL10 IL17A IL2 IL6 TNF
21
Show member pathways
11.7 FOXP3 IL2 TNF
22 11.7 IL10 IL6 TNF
23
Show member pathways
11.61 IL2 IL6 TNF
24 11.6 IL10 IL2 IL6 TNF
25
Show member pathways
11.54 RBP3 RHO RLBP1
26 11.5 IL2 IL6 TNF
27 11.48 IL10 IL6 TNF
28 11.47 IL10 IL6 TNF
29 11.44 FOXP3 IL10 IL2
30 11.33 IL10 IL6 TNF
31 11.3 IL10 IL6 TNF
32 11.26 CCR6 IL10 IL17A IL2 TNF
33 11.23 IL17A IL6 TNF
34 11.19 RBP3 RHO RLBP1 SAG
35 11.03 IL10 IL17A IL2 IL6 TNF
36 11.02 IL6 TNF
37 10.95 IL6 TNF
38 10.94 IL10 IL17A IL2 IL6 TNF
39 10.92 IL10 IL2 IL6 TNF
40 10.87 IL10 IL17A IL2 IL6 TNF

GO Terms for Autoimmune Disease of Eyes, Ear, Nose and Throat

Biological processes related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 IL10 IL17A IL6 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 IL10 IL6 TNF
3 regulation of signaling receptor activity GO:0010469 9.77 IL10 IL17A IL2 IL6 TNF
4 visual perception GO:0007601 9.71 CRYBB2 RBP3 RHO RLBP1
5 response to glucocorticoid GO:0051384 9.7 IL10 IL6 TNF
6 positive regulation of osteoclast differentiation GO:0045672 9.64 IL17A TNF
7 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
8 humoral immune response GO:0006959 9.63 CCR6 IL6 TNF
9 positive regulation of glial cell proliferation GO:0060252 9.62 IL6 TNF
10 regulation of regulatory T cell differentiation GO:0045589 9.62 FOXP3 IL2
11 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
13 retinoid metabolic process GO:0001523 9.61 RBP3 RHO RLBP1
14 positive regulation of immunoglobulin secretion GO:0051024 9.59 IL2 IL6
15 positive regulation of regulatory T cell differentiation GO:0045591 9.58 FOXP3 IL2
16 rhodopsin mediated signaling pathway GO:0016056 9.58 RHO SAG
17 negative regulation of lipid storage GO:0010888 9.56 IL6 TNF
18 endothelial cell apoptotic process GO:0072577 9.55 IL10 TNF
19 cytokine-mediated signaling pathway GO:0019221 9.55 IL10 IL17A IL2 IL6 TNF
20 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 FOXP3 IL2
21 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 IL10 TNF
22 negative regulation of lymphocyte proliferation GO:0050672 9.49 FOXP3 IL2
23 positive regulation of neuroinflammatory response GO:0150078 9.48 IL6 TNF
24 negative regulation of interleukin-6 production GO:0032715 9.43 FOXP3 IL10 TNF
25 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
26 negative regulation of inflammatory response GO:0050728 9.26 FOXP3 IL10 IL2 NT5E
27 immune response GO:0006955 9.1 CCR6 IL10 IL17A IL2 IL6 TNF
28 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 FOXP3 IL10 IL17A IL2 IL6 TNF

Molecular functions related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinol binding GO:0019841 9.26 RBP3 RLBP1
2 retinal binding GO:0016918 9.16 RBP3 RLBP1
3 cytokine activity GO:0005125 9.02 IL10 IL17A IL2 IL6 TNF
4 11-cis retinal binding GO:0005502 8.96 RHO RLBP1

Sources for Autoimmune Disease of Eyes, Ear, Nose and Throat

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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