MCID: ATM008
MIFTS: 31

Autoimmune Disease of Eyes, Ear, Nose and Throat

Categories: Immune diseases, Neuronal diseases, Oral diseases

Aliases & Classifications for Autoimmune Disease of Eyes, Ear, Nose and Throat

MalaCards integrated aliases for Autoimmune Disease of Eyes, Ear, Nose and Throat:

Name: Autoimmune Disease of Eyes, Ear, Nose and Throat 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060030

Summaries for Autoimmune Disease of Eyes, Ear, Nose and Throat

Disease Ontology : 12 An autoimmune disease located in eyes, located in ears, located in nose and located in throat.

MalaCards based summary : Autoimmune Disease of Eyes, Ear, Nose and Throat is related to autoimmune uveitis and neurosyphilis. An important gene associated with Autoimmune Disease of Eyes, Ear, Nose and Throat is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eyes, ears and nose, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Autoimmune Disease of Eyes, Ear, Nose and Throat

Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 767)
# Related Disease Score Top Affiliating Genes
1 autoimmune uveitis 31.4 TNF SAG RBP3 IL4 IL2 IL1B
2 neurosyphilis 10.5 IL17A IL10
3 coccidioidomycosis 10.4 IL17A CD4 CCR6
4 panophthalmitis 10.4 SAG CD4
5 punctate inner choroidopathy 10.4 TNF IL10
6 purulent endophthalmitis 10.4 RBP3 CD4
7 optic papillitis 10.4 SAG RBP3 CD4
8 external pathological resorption 10.4 TNF IL6
9 ophthalmomyiasis 10.4 SAG RBP3 CD4
10 birdshot chorioretinopathy 10.4 RBP3 IL17A CCR6
11 scabies 10.4 IL10 CD4 CCR6
12 immunodeficiency 35 10.4 IL10 ICOSLG CCR6
13 cork-handlers' disease 10.4 CD8A CD4
14 dermatophytosis 10.4 IL17A CD4 CCR6
15 necrotic uveal melanoma 10.4 CD8A CD4
16 scorpion envenomation 10.4 TNF IL6
17 acute transverse myelitis 10.4 IL6 IL10
18 caplan's syndrome 10.4 FOXP3 CD4
19 autoimmune atherosclerosis 10.4 FOXP3 CD4
20 sclerosing keratitis 10.4 RBP3 IL2
21 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.4 IL4 IL2
22 bullous skin disease 10.4 ICOSLG CD4 CCR6
23 autoimmune neuropathy 10.4 ICOSLG FOXP3 CD4
24 multifocal choroiditis 10.4 TNF IL10
25 early yaws 10.4 CD8A CD4
26 pars planitis 10.4 RBP3 IL2 CCR6
27 thrombocytopenic purpura, autoimmune 10.4 ICOSLG CD4 CCR6
28 central nervous system hematologic cancer 10.4 IL10 CD4 CCR6
29 chronic inflammatory demyelinating polyradiculoneuropathy 10.4 IL17A IL10 ICOSLG
30 oral candidiasis 10.4 IL17A CD4 CCR6
31 idiopathic anterior uveitis 10.3 TNF IL6
32 systemic autoimmune disease 10.3 IL6 IL17A
33 ventilation pneumonitis 10.3 CD8A CD4
34 agammaglobulinemia, x-linked 10.3 ICOSLG CD4 CCR6
35 adult acute lymphocytic leukemia 10.3 CD8A CD4 CCR6
36 elephantiasis 10.3 IL4 IL10 CD4
37 macular holes 10.3 RBP3 IL6 CRYAA
38 rheumatoid arthritis interstitial lung disease 10.3 TNF CD4
39 pustulosis of palm and sole 10.3 TNF IL17A CCR6
40 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL6
41 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
42 blood protein disease 10.3 IL6 ICOSLG CCR6
43 cutaneous candidiasis 10.3 IL17F IL17A CCR6
44 nasopharyngitis 10.3 TNF IL17A CCR6
45 meningovascular neurosyphilis 10.3 TNF IL17A CD4
46 igg4-related disease 10.3 IL4 ICOSLG CCR6
47 cardiogenic shock 10.3 TNF IL6
48 virus associated hemophagocytic syndrome 10.3 IL4 IL2
49 pericardial tuberculosis 10.3 IL10 CD4
50 latent syphilis 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat:



Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat

Symptoms & Phenotypes for Autoimmune Disease of Eyes, Ear, Nose and Throat

MGI Mouse Phenotypes related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 CCR6 CD4 CD8A CTLA4 FOXP3 IL10
2 homeostasis/metabolism MP:0005376 10.21 CCR6 CD4 CTLA4 FOXP3 IL10 IL17A
3 endocrine/exocrine gland MP:0005379 10.17 CD4 CD8A CTLA4 FOXP3 IL10 IL17A
4 immune system MP:0005387 10.17 CCR6 CD4 CD8A CTLA4 FOXP3 IL10
5 digestive/alimentary MP:0005381 10.16 CD4 CTLA4 FOXP3 IL10 IL17A IL17F
6 integument MP:0010771 10 CD4 CD8A CTLA4 FOXP3 IL10 IL17A
7 no phenotypic analysis MP:0003012 9.7 CD4 FOXP3 IL10 IL17A IL2 IL4
8 respiratory system MP:0005388 9.61 CTLA4 FOXP3 IL10 IL17A IL17F IL2
9 vision/eye MP:0005391 9.32 FOXP3 IL10 IL2 IL4 IL6 MC5R

Drugs & Therapeutics for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Eyes, Ear, Nose and Throat

Genetic Tests for Autoimmune Disease of Eyes, Ear, Nose and Throat

Anatomical Context for Autoimmune Disease of Eyes, Ear, Nose and Throat

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

19
Eyes, Ears, Nose, Throat

Publications for Autoimmune Disease of Eyes, Ear, Nose and Throat

Variations for Autoimmune Disease of Eyes, Ear, Nose and Throat

Expression for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search GEO for disease gene expression data for Autoimmune Disease of Eyes, Ear, Nose and Throat.

Pathways for Autoimmune Disease of Eyes, Ear, Nose and Throat

Pathways related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 TNF IL6 IL4 IL27 IL2 IL1B
2
Show member pathways
13.86 TNF IL6 IL4 IL2 IL1B IL17A
3
Show member pathways
13.74 TNF IL6 IL4 IL27 IL2 IL1B
4
Show member pathways
13.57 TNF IL6 IL4 IL2 IL1B IL17A
5
Show member pathways
13.48 TNF IL6 IL4 IL2 IL1B IL17A
6
Show member pathways
13.41 TNF IL6 IL4 IL27 IL2 IL1B
7
Show member pathways
13.37 TNF IL6 IL4 IL2 IL1B IL17A
8
Show member pathways
12.78 TNF IL6 IL4 IL2 IL1B IL17A
9
Show member pathways
12.72 TNF IL4 IL2 IL10 ICOSLG CD4
10
Show member pathways
12.68 TNF IL6 IL2 IL1B IL17F IL17A
11
Show member pathways
12.64 TNF IL6 IL4 IL2 IL1B IL17A
12 12.62 TNF IL4 IL2 IL1B IL17A IL10
13
Show member pathways
12.6 TNF IL6 IL4 IL2 IL1B IL17F
14
Show member pathways
12.42 TNF IL6 IL2 IL10 CCR6
15
Show member pathways
12.42 TNF IL6 IL4 IL2 IL1B
16
Show member pathways
12.42 TNF IL6 IL4 IL1B IL17F IL17A
17
Show member pathways
12.41 IL2 ICOSLG CTLA4 CD4
18 12.37 TNF IL6 IL2 CD4
19
Show member pathways
12.34 TNF IL6 IL4 IL2 IL1B IL17A
20
Show member pathways
12.31 TNF IL6 IL2 IL1B IL10
21
Show member pathways
12.3 TNF IL4 IL1B IL10
22 12.27 TNF IL6 IL1B IL10
23
Show member pathways
12.23 TNF IL6 IL4 IL1B
24 12.22 TNF IL6 IL1B IL10
25 12.19 TNF IL6 IL2 IL1B IL10 CD8A
26 12.18 ICOSLG CTLA4 CD8A CD4
27 12.11 TNF IL6 IL4 IL2 IL1B
28 12.1 TNF IL6 IL4 IL2 IL10 CD8A
29
Show member pathways
12.08 IL4 IL2 IL1B CD8A CD4
30 12.08 TNF IL6 IL4 IL1B IL17F IL17A
31 12.03 TNF IL6 IL4 IL1B CD8A CD4
32 12 TNF IL6 IL1B IL10
33
Show member pathways
11.97 IL6 IL4 IL1B IL17F IL17A CD4
34
Show member pathways
11.96 IL6 IL17F IL17A FOXP3
35 11.96 TNF IL6 IL1B IL17A CTLA4
36 11.86 TNF IL6 IL1B IL10
37
Show member pathways
11.86 TNF IL4 IL2 FOXP3 CTLA4
38 11.85 TNF IL6 IL2 IL1B IL10 CD8A
39 11.82 IL6 IL4 IL2
40
Show member pathways
11.8 TNF IL6 IL27 IL2 IL1B IL17A
41
Show member pathways
11.77 TNF IL6 IL2 IL1B
42 11.77 TNF IL6 IL4 IL1B
43 11.75 CTLA4 CD8A CD4
44
Show member pathways
11.73 IL4 IL2 FOXP3
45
Show member pathways
11.68 TNF IL2 CD8A
46 11.66 TNF IL6 IL4 IL1B IL10
47 11.65 TNF IL6 IL1B
48 11.65 TNF IL6 IL1B IL10
49 11.63 IL4 IL2 IL10 FOXP3 CD4
50 11.6 TNF IL6 IL2

GO Terms for Autoimmune Disease of Eyes, Ear, Nose and Throat

Cellular components related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 TNF RBP3 IL6 IL4 IL27 IL2
2 extracellular space GO:0005615 9.65 TNF RBP3 IL6 IL4 IL27 IL2
3 external side of plasma membrane GO:0009897 9.17 TNF IL17A ICOSLG CTLA4 CD8A CD4

Biological processes related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.3 SAG RCVRN MC5R IL6 IL4 IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 TNF IL6 IL4 IL2 IL17F IL17A
3 positive regulation of transcription, DNA-templated GO:0045893 10.14 TNF IL6 IL4 IL1B IL10 FOXP3
4 positive regulation of gene expression GO:0010628 10.13 TNF IL6 IL4 IL1B FOXP3
5 immune system process GO:0002376 10.08 IL27 IL2 IL17F IL17A ICOSLG CTLA4
6 inflammatory response GO:0006954 10.04 TNF IL6 IL27 IL1B IL17F IL17A
7 positive regulation of protein phosphorylation GO:0001934 10 TNF IL2 IL1B CD4
8 T cell receptor signaling pathway GO:0050852 9.98 ICOSLG FOXP3 CTLA4 CD4
9 cellular response to lipopolysaccharide GO:0071222 9.98 TNF IL6 IL1B IL10
10 adaptive immune response GO:0002250 9.98 IL2 IL17F IL17A ICOSLG CTLA4 CD8A
11 negative regulation of inflammatory response GO:0050728 9.96 IL4 IL2 IL10 FOXP3
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 TNF IL6 IL1B IL10
13 defense response to Gram-positive bacterium GO:0050830 9.92 TNF IL6 IL17F IL17A
14 negative regulation of tumor necrosis factor production GO:0032720 9.9 IL4 IL10 FOXP3
15 regulation of insulin secretion GO:0050796 9.89 TNF IL6 IL1B
16 negative regulation of interleukin-6 production GO:0032715 9.89 TNF IL10 FOXP3
17 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10
18 defense response to Gram-negative bacterium GO:0050829 9.88 IL6 IL17F IL17A CD4
19 positive regulation of interleukin-8 production GO:0032757 9.87 TNF IL6 IL1B
20 humoral immune response GO:0006959 9.87 TNF IL6 CCR6
21 positive regulation of interleukin-1 beta production GO:0032731 9.87 TNF IL6 IL17A
22 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 TNF IL6 IL4 IL2
23 negative regulation of T cell proliferation GO:0042130 9.84 IL10 FOXP3 CTLA4
24 positive regulation of JAK-STAT cascade GO:0046427 9.81 TNF IL6 IL10
25 positive regulation of interferon-gamma production GO:0032729 9.81 TNF IL27 IL2 IL1B
26 negative regulation of neurogenesis GO:0050768 9.79 TNF IL6 IL1B
27 positive regulation of interleukin-6 production GO:0032755 9.77 TNF IL6 IL1B IL17F IL17A
28 positive regulation of immunoglobulin production GO:0002639 9.75 IL6 IL2 IL10
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IL4 IL10
30 positive regulation of glial cell proliferation GO:0060252 9.73 TNF IL6 IL1B
31 T cell mediated immunity GO:0002456 9.72 FOXP3 CD8A
32 regulation of establishment of endothelial barrier GO:1903140 9.72 TNF IL1B
33 interleukin-17-mediated signaling pathway GO:0097400 9.71 IL17F IL17A
34 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IL4 IL2
35 negative regulation of lipid storage GO:0010888 9.71 TNF IL6
36 regulation of immunoglobulin production GO:0002637 9.71 TNF FOXP3
37 regulation of regulatory T cell differentiation GO:0045589 9.71 IL2 FOXP3 CTLA4
38 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 TNF IL1B IL10
40 positive regulation of mononuclear cell migration GO:0071677 9.69 TNF IL4
41 negative regulation of lymphocyte proliferation GO:0050672 9.69 IL2 FOXP3
42 negative regulation of cytokine production involved in immune response GO:0002719 9.68 TNF IL10
43 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.68 IL17F IL17A
44 type 2 immune response GO:0042092 9.67 IL4 IL10
45 positive regulation of fever generation GO:0031622 9.67 TNF IL1B
46 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL6 IL1B
47 positive regulation of immature T cell proliferation in thymus GO:0033092 9.66 IL1B FOXP3
48 sequestering of triglyceride GO:0030730 9.66 TNF IL1B
49 positive regulation of plasma cell differentiation GO:1900100 9.65 IL2 IL10
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.65 TNF IL1B

Molecular functions related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TNF IL6 IL4 IL27 IL2 IL1B
2 growth factor activity GO:0008083 9.26 IL6 IL4 IL2 IL10

Sources for Autoimmune Disease of Eyes, Ear, Nose and Throat

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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