MCID: ATM008
MIFTS: 30

Autoimmune Disease of Eyes, Ear, Nose and Throat

Categories: Ear diseases, Immune diseases, Neuronal diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Autoimmune Disease of Eyes, Ear, Nose and Throat

MalaCards integrated aliases for Autoimmune Disease of Eyes, Ear, Nose and Throat:

Name: Autoimmune Disease of Eyes, Ear, Nose and Throat 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060030

Summaries for Autoimmune Disease of Eyes, Ear, Nose and Throat

Disease Ontology : 12 An autoimmune hypersensitivity disease located in eyes, located in ears, located in nose and located in throat.

MalaCards based summary : Autoimmune Disease of Eyes, Ear, Nose and Throat is related to autoimmune uveitis and acute zonal occult outer retinopathy. An important gene associated with Autoimmune Disease of Eyes, Ear, Nose and Throat is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. Affiliated tissues include eyes, ears and nose, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Disease of Eyes, Ear, Nose and Throat

Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 autoimmune uveitis 30.8 CAPN5 IL10 IL17A IL2 RBP3 RLBP1
2 acute zonal occult outer retinopathy 10.4 RLBP1 SAG
3 palladium allergic contact dermatitis 10.4 IL10 IL17A
4 autoimmune atherosclerosis 10.3 FOXP3 IL10
5 autoimmune enteropathy 10.3 FOXP3 IL17A
6 neurosyphilis 10.3 IL10 IL17A
7 chorioretinitis 10.3 RBP3 SAG
8 melanoma-associated retinopathy 10.3 RHO SAG
9 apple allergy 10.3 FOXP3 IL10
10 pineocytoma 10.2 RHO SAG
11 autoimmune optic neuritis 10.2 FOXP3 IL10 IL17A
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 FOXP3 IL10 IL17A
13 bardet-biedl syndrome 5 10.2 RHO SAG
14 vulvovaginitis 10.2 CCL5 IL10
15 cancer-associated retinopathy 10.2 RHO SAG
16 eye lymphoma 10.1 IL10 IL6
17 acute transverse myelitis 10.1 IL10 IL6
18 panuveitis 10.1 IL10 IL17A RBP3 SAG
19 funisitis 10.1 IL10 IL6
20 viral pneumonia 10.1 IL17A IL6
21 congenital stationary night blindness 10.1 RBP3 RHO SAG
22 retinal disease 10.1 RHO RLBP1 SAG
23 paraneoplastic syndromes 10.1 IL6 RHO
24 stromal keratitis 10.1 CCR6 IL17A IL6
25 allergic asthma 10.1 CCL5 IL10 IL17A
26 scorpion envenomation 10.1 CCL5 IL6
27 demyelinating disease 10.1 CCL5 IL10 IL17A
28 bacterial infectious disease 10.0 IL10 IL17A IL6
29 cystic echinococcosis 10.0 IL10 IL17A IL6
30 echinococcosis 10.0 IL10 IL17A IL6
31 transverse myelitis 10.0 IL10 IL17A IL6
32 mycoplasma pneumoniae pneumonia 10.0 IL10 IL17A IL6
33 radiculopathy 10.0 IL10 IL17A IL6
34 extrinsic cardiomyopathy 10.0 IL10 IL17A IL6
35 retinal degeneration 10.0 RHO RLBP1 SAG
36 spondyloarthropathy 10.0 IL10 IL17A IL6
37 obesity-hypoventilation syndrome 10.0 CCL5 IL6
38 bronchiolitis obliterans 10.0 IL10 IL17A IL6
39 chronic mucocutaneous candidiasis 10.0 IL10 IL17A IL6
40 multicentric castleman disease 10.0 IL10 IL6
41 periodontitis 10.0 IL10 IL17A IL6
42 central nervous system vasculitis 10.0 IL17A IL6
43 fundus albipunctatus 10.0 RBP3 RHO RLBP1 SAG
44 gaucher disease, type ii 10.0 IL10 IL2
45 clonorchiasis 10.0 IL10 IL2
46 t-cell adult acute lymphocytic leukemia 10.0 FOXP3 IL2
47 retinitis pigmentosa 44 9.9 IL10 IL2
48 relapsing-remitting multiple sclerosis 9.9 CCL5 FOXP3 IL10 IL17A
49 eales disease 9.9 IL10 IL6 RBP3 SAG
50 uveitis 9.9 CAPN5 IL10 IL17A RBP3 SAG

Graphical network of the top 20 diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat:



Diseases related to Autoimmune Disease of Eyes, Ear, Nose and Throat

Symptoms & Phenotypes for Autoimmune Disease of Eyes, Ear, Nose and Throat

MGI Mouse Phenotypes related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CCL5 CCR6 FOXP3 IL10 IL17A IL2
2 immune system MP:0005387 9.61 CAPN5 CCL5 CCR6 FOXP3 IL10 IL17A
3 vision/eye MP:0005391 9.28 CRYBB2 FOXP3 IL10 IL2 IL6 RBP3

Drugs & Therapeutics for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Eyes, Ear, Nose and Throat

Genetic Tests for Autoimmune Disease of Eyes, Ear, Nose and Throat

Anatomical Context for Autoimmune Disease of Eyes, Ear, Nose and Throat

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

20
Eyes, Ears, Nose, Throat

MalaCards organs/tissues related to Autoimmune Disease of Eyes, Ear, Nose and Throat:

42
Eye

Publications for Autoimmune Disease of Eyes, Ear, Nose and Throat

Variations for Autoimmune Disease of Eyes, Ear, Nose and Throat

Expression for Autoimmune Disease of Eyes, Ear, Nose and Throat

Search GEO for disease gene expression data for Autoimmune Disease of Eyes, Ear, Nose and Throat.

Pathways for Autoimmune Disease of Eyes, Ear, Nose and Throat

Pathways related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 CCL5 CCR6 IL10 IL17A IL2 IL6
2
Show member pathways
13.14 CCL5 CCR6 IL10 IL17A IL2 IL6
3
Show member pathways
12.71 FOXP3 IL10 IL17A IL2 IL6
4
Show member pathways
12.44 IL10 IL17A IL2 IL6
5
Show member pathways
12.39 FOXP3 IL10 IL17A IL2 IL6
6
Show member pathways
12.28 IL10 IL17A IL2 IL6
7
Show member pathways
12.17 RBP3 RHO RLBP1 SAG
8
Show member pathways
12.12 IL10 IL17A IL2 IL6
9
Show member pathways
12.06 IL10 IL2 IL6
10 11.95 CCL5 FOXP3 IL10 IL17A IL2 NT5E
11
Show member pathways
11.89 CCL5 IL10 IL17A IL2 IL6
12 11.86 IL10 IL2 IL6
13 11.85 IL10 IL17A IL6
14
Show member pathways
11.85 IL10 IL17A IL2 IL6
15 11.75 IL10 IL2 IL6
16
Show member pathways
11.74 FOXP3 IL17A IL6
17 11.72 CCL5 IL17A IL6
18 11.6 IL10 IL2 IL6
19 11.6 RBP3 RHO RLBP1 SAG
20 11.46 CCR6 IL10 IL17A IL2
21
Show member pathways
11.44 RBP3 RHO RLBP1
22 11.38 CCL5 IL10 IL6
23 11.33 FOXP3 IL10 IL2
24 11.05 IL10 IL2
25 11.04 IL10 IL2 IL6
26 11.03 RBP3 RHO RLBP1 SAG
27 10.87 CCL5 IL10 IL17A IL2 IL6
28 10.85 CCL5 IL10 IL17A IL2 IL6
29 10.78 CCL5 IL10 IL17A IL2 IL6

GO Terms for Autoimmune Disease of Eyes, Ear, Nose and Throat

Biological processes related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.86 CCL5 IL10 IL17A IL6
2 regulation of signaling receptor activity GO:0010469 9.65 CCL5 IL10 IL17A IL2 IL6
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.63 CCL5 IL2 IL6
4 visual perception GO:0007601 9.62 CRYBB2 RBP3 RHO RLBP1
5 positive regulation of T cell proliferation GO:0042102 9.61 CCL5 IL2 IL6
6 positive regulation of JAK-STAT cascade GO:0046427 9.58 CCL5 IL6
7 regulation of rhodopsin mediated signaling pathway GO:0022400 9.57 RHO SAG
8 dendritic cell chemotaxis GO:0002407 9.55 CCL5 CCR6
9 cytokine-mediated signaling pathway GO:0019221 9.55 CCL5 IL10 IL17A IL2 IL6
10 regulation of regulatory T cell differentiation GO:0045589 9.54 FOXP3 IL2
11 retinoid metabolic process GO:0001523 9.54 RBP3 RHO RLBP1
12 positive regulation of immunoglobulin secretion GO:0051024 9.52 IL2 IL6
13 positive regulation of regulatory T cell differentiation GO:0045591 9.51 FOXP3 IL2
14 rhodopsin mediated signaling pathway GO:0016056 9.49 RHO SAG
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.48 FOXP3 IL2
16 negative regulation of lymphocyte proliferation GO:0050672 9.4 FOXP3 IL2
17 negative regulation of inflammatory response GO:0050728 9.26 FOXP3 IL10 IL2 NT5E
18 immune response GO:0006955 9.1 CCL5 CCR6 IL10 IL17A IL2 IL6

Molecular functions related to Autoimmune Disease of Eyes, Ear, Nose and Throat according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 IL10 IL2 IL6
2 retinol binding GO:0019841 9.26 RBP3 RLBP1
3 retinal binding GO:0016918 9.16 RBP3 RLBP1
4 cytokine activity GO:0005125 9.02 CCL5 IL10 IL17A IL2 IL6
5 11-cis retinal binding GO:0005502 8.96 RHO RLBP1

Sources for Autoimmune Disease of Eyes, Ear, Nose and Throat

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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