MCID: ATM015
MIFTS: 27

Autoimmune Disease of Gastrointestinal Tract

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Gastrointestinal Tract

MalaCards integrated aliases for Autoimmune Disease of Gastrointestinal Tract:

Name: Autoimmune Disease of Gastrointestinal Tract 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060031

Summaries for Autoimmune Disease of Gastrointestinal Tract

Disease Ontology : 12 An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.

MalaCards based summary : Autoimmune Disease of Gastrointestinal Tract is related to autoimmune hepatitis and autoimmune gastritis. An important gene associated with Autoimmune Disease of Gastrointestinal Tract is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. Affiliated tissues include t cells.

Related Diseases for Autoimmune Disease of Gastrointestinal Tract

Diseases related to Autoimmune Disease of Gastrointestinal Tract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 764)
# Related Disease Score Top Affiliating Genes
1 autoimmune hepatitis 32.6 TNF IL17A IL10 DLAT
2 autoimmune gastritis 32.6 TNF IL6 IL1B IL10 CD4 CCR6
3 celiac disease 1 32.2 TOR1A TNF TGM2 NOD2 MIR192 IL6
4 conjunctivitis 10.6 TNF IL6 IL10
5 neurosyphilis 10.6 IL17A IL10
6 enterocolitis 10.6 TNF IL6 IL10
7 schistosomiasis 10.6 TNF IL17A IL10
8 jejunoileitis 10.6 TOR1A TNF TGM2
9 punctate inner choroidopathy 10.6 TNF IL10
10 external pathological resorption 10.6 TNF IL6
11 scabies 10.6 IL10 CD4 CCR6
12 physiological polycythemia 10.6 TNF IL6 IL1B
13 mikulicz disease 10.6 IL10 CD4 CCR6
14 meningovascular neurosyphilis 10.6 TNF IL17A CD4
15 tropical endomyocardial fibrosis 10.6 TNF IL10
16 pustulosis of palm and sole 10.6 TNF IL17A CCR6
17 inflammatory bowel disease 5 10.6 NOD2 ICOSLG CCR6
18 scorpion envenomation 10.6 TNF IL6
19 immunodeficiency 35 10.6 IL10 ICOSLG CCR6
20 gastrointestinal tuberculosis 10.6 TNF NOD2 CD4
21 intestinal tuberculosis 10.6 TNF NOD2 CD4
22 type 1 diabetes mellitus 23 10.6 TNF CD8A CD4
23 sialadenitis 10.6 TNF ICOSLG CD4 CCR6
24 post-transplant lymphoproliferative disease 10.6 TNF IL6 IL10
25 ulcer of lower limbs 10.6 TNF IL6 IL1B
26 whipple disease 10.6 TOR1A TNF TGM2 CD4
27 arachnoiditis 10.6 TNF IL1B CD4
28 lung abscess 10.6 TNF IL6 CD4
29 sigmoid disease 10.6 TNF NOD2
30 chancroid 10.6 DLAT CD4 CCR6
31 legume allergy 10.6 IL10 ICOSLG CD4 CCR6
32 fruit allergy 10.6 IL10 ICOSLG CD4 CCR6
33 progressive myoclonus epilepsy 8 10.6 TNF IL6 IL10
34 inflammatory bowel disease 1 10.6 NOD2 IL6 CCR6
35 orofacial granulomatosis 10.6 TNF NOD2 IL10
36 skin sarcoidosis 10.6 TNF CD8A CD4
37 blood protein disease 10.6 IL6 ICOSLG H2AC18 CCR6
38 stachybotrys chartarum 10.6 TNF IL6 IL1B
39 retinal vasculitis 10.6 TNF CD4 CCR6
40 carbuncle 10.6 TNF IL6 IL1B
41 posterior uveitis 10.6 TNF IL6 ICOSLG CCR6
42 respiratory allergy 10.6 IL10 ICOSLG CD4 CCR6
43 selective immunoglobulin deficiency disease 10.6 TGM2 ICOSLG CD8A
44 salpingitis 10.6 TNF IL6 CD4
45 tuberculoid leprosy 10.6 TNF IL10 CD4 CCR6
46 monoclonal gammopathy of uncertain significance 10.6 TNF IL6 ICOSLG CCR6
47 oral tuberculosis 10.6 TNF CD8A CD4
48 granulomatous hepatitis 10.6 TNF CD8A CD4
49 dermatophytosis 10.6 IL17A CD4 CCR6
50 anthracosis 10.6 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Autoimmune Disease of Gastrointestinal Tract:



Diseases related to Autoimmune Disease of Gastrointestinal Tract

Symptoms & Phenotypes for Autoimmune Disease of Gastrointestinal Tract

Drugs & Therapeutics for Autoimmune Disease of Gastrointestinal Tract

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Gastrointestinal Tract

Genetic Tests for Autoimmune Disease of Gastrointestinal Tract

Anatomical Context for Autoimmune Disease of Gastrointestinal Tract

MalaCards organs/tissues related to Autoimmune Disease of Gastrointestinal Tract:

40
T Cells

Publications for Autoimmune Disease of Gastrointestinal Tract

Variations for Autoimmune Disease of Gastrointestinal Tract

Expression for Autoimmune Disease of Gastrointestinal Tract

Search GEO for disease gene expression data for Autoimmune Disease of Gastrointestinal Tract.

Pathways for Autoimmune Disease of Gastrointestinal Tract

Pathways related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 TNF NOD2 IL6 IL1B IL17A IL10
2
Show member pathways
13.28 TNF IL6 IL1B IL17A IL10 CD4
3
Show member pathways
12.75 TNF IL6 IL1B IL17A IL10 ICOSLG
4
Show member pathways
12.59 TNF IL6 IL1B IL17A IL10 CD4
5 12.54 TNF IL1B IL17A IL10 CD8A
6
Show member pathways
12.54 TNF IL6 IL1B IL17A IL10 CD8A
7
Show member pathways
12.51 TNF NOD2 IL6 IL1B IL17A IL10
8
Show member pathways
12.31 TNF IL6 IL1B IL17A
9
Show member pathways
12.31 TNF IL6 IL10 CCR6
10
Show member pathways
12.3 TNF SERPINA3 IL6 IL1B
11
Show member pathways
12.24 TNF IL6 IL1B IL17A IL10
12 12.24 TNF NOD2 IL6 IL1B IL10
13 12.21 TNF NOD2 IL6 IL1B
14
Show member pathways
12.19 TNF IL6 IL1B IL10
15 12.15 TNF IL6 IL1B IL10
16 12.01 TNF IL6 IL10 CD8A CD4
17 11.99 TNF IL6 IL1B IL17A IL10
18 11.97 TNF NOD2 IL6 IL1B
19 11.94 TNF IL6 IL1B IL10 CD8A CD4
20 11.92 TNF IL6 IL1B IL10
21 11.89 TNF IL6 IL1B CD8A CD4
22 11.87 TNF IL6 IL1B IL17A
23
Show member pathways
11.86 IL6 IL1B IL17A CD4
24 11.77 TNF IL6 IL1B IL10
25
Show member pathways
11.64 TNF IL6 IL1B
26 11.63 TNF IL6 IL1B
27 11.59 TNF IL6 IL1B
28 11.59 TNF IL6 IL10 ICOSLG CCR6
29 11.57 TNF IL6 IL1B IL10
30 11.55 TNF IL6 IL1B IL10
31
Show member pathways
11.51 TNF IL6 IL1B IL17A IL10 CD4
32 11.47 TNF IL6 IL1B
33 11.39 TNF IL6 IL1B IL10
34 11.36 TNF IL6 IL1B IL10
35 11.3 TNF IL6 IL1B IL10 CD8A CD4
36 11.29 TNF IL6 IL1B
37 11.28 TNF IL6 IL1B IL17A
38 11.12 TNF IL6 IL1B IL10 CD4
39 11.07 TNF IL1B IL17A IL10 CD8A CD4

GO Terms for Autoimmune Disease of Gastrointestinal Tract

Cellular components related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 TNF SERPINA3 MIRLET7E MIR223 MIR192 MIR125B1
2 external side of plasma membrane GO:0009897 9.1 TNF IL17A ICOSLG CD8A CD4 CCR6

Biological processes related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.03 TNF SERPINA3 IL6 IL1B IL17A
2 positive regulation of protein phosphorylation GO:0001934 9.94 TNF MIR125B1 IL1B CD4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 TNF TGM2 NOD2 CD4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNF NOD2 IL6 IL1B
5 cellular response to lipopolysaccharide GO:0071222 9.88 TNF NOD2 IL6 IL1B IL10
6 negative regulation of tumor necrosis factor production GO:0032720 9.86 NOD2 MIR125B1 IL10
7 regulation of insulin secretion GO:0050796 9.85 TNF IL6 IL1B
8 negative regulation of interleukin-6 production GO:0032715 9.85 TNF MIRLET7E IL10
9 cellular response to organic cyclic compound GO:0071407 9.85 TNF NOD2 IL1B
10 cytokine-mediated signaling pathway GO:0019221 9.85 TNF IL6 IL1B IL17A IL10 CD4
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 TNF NOD2 IL1B
12 response to glucocorticoid GO:0051384 9.84 TNF IL6 IL10
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 TNF IL6 IL1B IL10
14 defense response to Gram-positive bacterium GO:0050830 9.83 TNF NOD2 IL6 IL17A
15 positive regulation of T cell proliferation GO:0042102 9.82 IL6 IL1B CD4
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 TNF TGM2 IL6
17 humoral immune response GO:0006959 9.81 TNF IL6 CCR6
18 positive regulation of phagocytosis GO:0050766 9.76 TNF NOD2 IL1B
19 positive regulation of interleukin-8 production GO:0032757 9.76 TNF NOD2 IL6 IL1B
20 T cell activation GO:0042110 9.75 ICOSLG CD8A CD4
21 positive regulation of JAK-STAT cascade GO:0046427 9.72 TNF IL6 IL10
22 positive regulation of interleukin-1 beta production GO:0032731 9.71 TNF NOD2 IL6 IL17A
23 negative regulation of neurogenesis GO:0050768 9.69 TNF IL6 IL1B
24 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
25 negative regulation of lipid storage GO:0010888 9.67 TNF IL6
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 TNF IL1B IL10
27 negative regulation of STAT cascade GO:1904893 9.66 MIRLET7E MIR125B1
28 endothelial cell apoptotic process GO:0072577 9.65 TNF IL10
29 response to peptidoglycan GO:0032494 9.65 NOD2 IL6
30 positive regulation of interleukin-6 production GO:0032755 9.65 TNF NOD2 IL6 IL1B IL17A
31 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.62 TNF NOD2
32 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
33 negative regulation of interleukin-18 production GO:0032701 9.61 NOD2 IL10
34 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL6 IL1B
35 positive regulation of fever generation GO:0031622 9.6 TNF IL1B
36 sequestering of triglyceride GO:0030730 9.57 TNF IL1B
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 TNF IL1B
38 immune response GO:0006955 9.56 TNF IL6 IL1B IL17A IL10 CD8A
39 vascular endothelial growth factor production GO:0010573 9.5 TNF IL6 IL1B
40 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.46 TNF NOD2 IL6 IL17A
41 positive regulation of glial cell proliferation GO:0060252 8.92 TNF MIR125B1 IL6 IL1B

Molecular functions related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.35 MIRLET7E MIR223 MIR196A1 MIR192 MIR125B1
2 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IL17A IL10

Sources for Autoimmune Disease of Gastrointestinal Tract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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