MCID: ATM015
MIFTS: 22

Autoimmune Disease of Gastrointestinal Tract

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Gastrointestinal Tract

MalaCards integrated aliases for Autoimmune Disease of Gastrointestinal Tract:

Name: Autoimmune Disease of Gastrointestinal Tract 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060031

Summaries for Autoimmune Disease of Gastrointestinal Tract

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.

MalaCards based summary : Autoimmune Disease of Gastrointestinal Tract is related to autoimmune hepatitis and celiac disease 1. An important gene associated with Autoimmune Disease of Gastrointestinal Tract is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Rheumatoid arthritis. Affiliated tissues include t cells, skin and heart, and related phenotypes are no effect and hematopoietic system

Related Diseases for Autoimmune Disease of Gastrointestinal Tract

Diseases related to Autoimmune Disease of Gastrointestinal Tract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 autoimmune hepatitis 31.6 CTLA4 CYP2D6 FTCD GPT SEPSECS
2 celiac disease 1 31.0 CTLA4 HLA-DQA1 IL15 MYO9B TAGAP TGM2
3 autoimmune gastritis 11.1
4 adie pupil 10.4 TNFRSF25 TOR1A
5 wheat allergy 10.4 TGM2 TOR1A
6 type 1 diabetes mellitus 18 10.4 TNFRSF10A TNFRSF25
7 heart block, congenital 10.4 TNFRSF25 TOR1A
8 spinocerebellar ataxia 35 10.4 TGM2 TGM6
9 autoimmune disease of skin and connective tissue 10.4 TGM2 TNFRSF25 TOR1A
10 immunoglobulin alpha deficiency 10.4 TGM2 TNFRSF25 TOR1A
11 hirata disease 10.4 HLA-DQA1 TNFRSF10A
12 adult-onset myasthenia gravis 10.3 CTLA4 HLA-DQA1
13 childhood type dermatomyositis 10.3 HLA-DQA1 TNFRSF25
14 type 1 diabetes mellitus 17 10.3 CTLA4 TNFRSF25
15 torticollis 10.3 TGM6 TOR1A
16 immune system disease 10.3 TGM2 TNFRSF25 TOR1A
17 cholangitis, primary sclerosing 10.3 GPT SEPSECS TNFRSF25
18 type 1 diabetes mellitus 11 10.3 CTLA4 TNFRSF25
19 viral hepatitis 10.3 GPT HLA-DQA1 SEPSECS
20 hepatitis d 10.3 CYP2D6 GPT
21 refractory celiac disease 10.3 IL15 MYO9B
22 herpangina 10.3 TNFRSF10A TNFRSF25
23 extratemporal epilepsy 10.3 TGM2 TOR1A
24 type 1 diabetes mellitus 5 10.2 CTLA4 TNFRSF10A TNFRSF25
25 autoimmune disease of endocrine system 10.2 CTLA4 TNFRSF10A TNFRSF25
26 sympathetic ophthalmia 10.2 CTLA4 HLA-DQA1
27 adrenal cortical hypofunction 10.2 TNFRSF25 TOR1A
28 dermatitis herpetiformis 10.2 HLA-DQA1 MYO9B TGM2 TGM6
29 gastrointestinal neuroendocrine benign tumor 10.1 CBLIF GAST
30 granulomatous gastritis 10.1 CBLIF GAST
31 amelogenesis imperfecta, type ib 10.1 ASGR1 CYP2D6 FTCD SEPSECS
32 gastric neuroendocrine neoplasm 10.1 CBLIF GAST
33 amelogenesis imperfecta, type ie 10.1 ASGR1 CYP2D6 FTCD SEPSECS
34 pernicious anemia 10.0 CBLIF GAST
35 neuroretinitis 10.0 CTLA4 TNFRSF10A
36 diphyllobothriasis 10.0 CBLIF GAST

Graphical network of the top 20 diseases related to Autoimmune Disease of Gastrointestinal Tract:



Diseases related to Autoimmune Disease of Gastrointestinal Tract

Symptoms & Phenotypes for Autoimmune Disease of Gastrointestinal Tract

GenomeRNAi Phenotypes related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ASGR1 CBLIF CCR6 CTLA4 CYP2D6 FTCD

MGI Mouse Phenotypes related to Autoimmune Disease of Gastrointestinal Tract:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 ASGR1 CBLIF CCR6 CTLA4 HLA-DQA1 IL15
2 immune system MP:0005387 9.4 ASGR1 CBLIF CCR6 CTLA4 GAST HLA-DQA1

Drugs & Therapeutics for Autoimmune Disease of Gastrointestinal Tract

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Gastrointestinal Tract

Genetic Tests for Autoimmune Disease of Gastrointestinal Tract

Anatomical Context for Autoimmune Disease of Gastrointestinal Tract

MalaCards organs/tissues related to Autoimmune Disease of Gastrointestinal Tract:

42
T Cells, Skin, Heart

Publications for Autoimmune Disease of Gastrointestinal Tract

Variations for Autoimmune Disease of Gastrointestinal Tract

Expression for Autoimmune Disease of Gastrointestinal Tract

Search GEO for disease gene expression data for Autoimmune Disease of Gastrointestinal Tract.

Pathways for Autoimmune Disease of Gastrointestinal Tract

Pathways related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 CTLA4 HLA-DQA1 ICOSLG
2 11.29 CTLA4 HLA-DQA1 IL15
3 10.56 CTLA4 ICOSLG TNFRSF25
4 9.8 CBLIF GAST

GO Terms for Autoimmune Disease of Gastrointestinal Tract

Biological processes related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.28 CCR6 GAST ICOSLG IL15 MYO9B SH2B3

Molecular functions related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.62 TGM2 TGM6

Sources for Autoimmune Disease of Gastrointestinal Tract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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