MCID: ATM015
MIFTS: 20

Autoimmune Disease of Gastrointestinal Tract

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Gastrointestinal Tract

MalaCards integrated aliases for Autoimmune Disease of Gastrointestinal Tract:

Name: Autoimmune Disease of Gastrointestinal Tract 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060031

Summaries for Autoimmune Disease of Gastrointestinal Tract

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.

MalaCards based summary : Autoimmune Disease of Gastrointestinal Tract is related to autoimmune hepatitis and celiac disease 1. An important gene associated with Autoimmune Disease of Gastrointestinal Tract is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are Rheumatoid arthritis and Gastric acid production. Affiliated tissues include t cells, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Autoimmune Disease of Gastrointestinal Tract

Diseases related to Autoimmune Disease of Gastrointestinal Tract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 autoimmune hepatitis 31.8 CTLA4 CYP2D6 FTCD SEPSECS
2 celiac disease 1 30.2 CTLA4 HLA-DQA1 IL15 KLRC3 MYO9B PREP
3 autoimmune gastritis 11.1
4 adie pupil 10.3 TNFRSF25 TOR1A
5 wheat allergy 10.3 TGM2 TOR1A
6 type 1 diabetes mellitus 18 10.3 TNFRSF10A TNFRSF25
7 heart block, congenital 10.3 TNFRSF25 TOR1A
8 spinocerebellar ataxia 35 10.3 TGM2 TGM6
9 hirata disease 10.2 HLA-DQA1 TNFRSF10A
10 adult-onset myasthenia gravis 10.2 CTLA4 HLA-DQA1
11 autoimmune disease of skin and connective tissue 10.2 TGM2 TNFRSF25 TOR1A
12 immunoglobulin alpha deficiency 10.2 TGM2 TNFRSF25 TOR1A
13 type 1 diabetes mellitus 17 10.2 CTLA4 TNFRSF25
14 childhood type dermatomyositis 10.2 HLA-DQA1 TNFRSF25
15 torticollis 10.2 TGM6 TOR1A
16 type 1 diabetes mellitus 11 10.2 CTLA4 TNFRSF25
17 refractory celiac disease 10.2 IL15 MYO9B
18 sympathetic ophthalmia 10.2 CTLA4 HLA-DQA1
19 type 1 diabetes mellitus 5 10.2 CTLA4 TNFRSF10A TNFRSF25
20 herpangina 10.2 TNFRSF10A TNFRSF25
21 autoimmune disease of endocrine system 10.2 CTLA4 TNFRSF10A TNFRSF25
22 extratemporal epilepsy 10.2 TGM2 TOR1A
23 adrenal cortical hypofunction 10.1 TNFRSF25 TOR1A
24 dermatitis herpetiformis 10.1 HLA-DQA1 MYO9B TGM2 TGM6
25 amelogenesis imperfecta, type ib 10.1 ASGR1 CYP2D6 FTCD SEPSECS
26 amelogenesis imperfecta, type ie 10.1 ASGR1 CYP2D6 FTCD SEPSECS
27 gastrointestinal neuroendocrine benign tumor 10.1 CBLIF GAST
28 granulomatous gastritis 10.1 CBLIF GAST
29 gastric neuroendocrine neoplasm 10.1 CBLIF GAST
30 pernicious anemia 10.0 CBLIF GAST
31 diphyllobothriasis 10.0 CBLIF GAST
32 diabetes mellitus, insulin-dependent 10.0 CTLA4 HLA-DQA1 SH2B3 TNFRSF10A TNFRSF25
33 neuroretinitis 10.0 CTLA4 TNFRSF10A
34 immune system disease 9.9 CTLA4 SCHIP1 TGM2 TNFRSF10A TNFRSF25 TOR1A

Graphical network of the top 20 diseases related to Autoimmune Disease of Gastrointestinal Tract:



Diseases related to Autoimmune Disease of Gastrointestinal Tract

Symptoms & Phenotypes for Autoimmune Disease of Gastrointestinal Tract

GenomeRNAi Phenotypes related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.05 MYO9B
2 Decreased viability GR00221-A-2 10.05 MYO9B
3 Decreased viability GR00221-A-4 10.05 MYO9B
4 Decreased viability GR00342-S-3 10.05 TNFRSF10A
5 Decreased viability GR00381-A-1 10.05 CYP2D6
6 Decreased viability GR00402-S-2 10.05 ASGR1 CBLIF CTLA4 CYP2D6 FTCD GAST
7 no effect GR00402-S-1 9.62 ASGR1 CBLIF CTLA4 CYP2D6 FTCD GAST

MGI Mouse Phenotypes related to Autoimmune Disease of Gastrointestinal Tract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 CTLA4 GAST HLA-DQA1 IL15 SCHIP1 TGM2
2 hematopoietic system MP:0005397 9.7 ASGR1 CBLIF CTLA4 HLA-DQA1 IL15 MYO9B
3 immune system MP:0005387 9.4 ASGR1 CBLIF CTLA4 GAST HLA-DQA1 IL15

Drugs & Therapeutics for Autoimmune Disease of Gastrointestinal Tract

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Gastrointestinal Tract

Genetic Tests for Autoimmune Disease of Gastrointestinal Tract

Anatomical Context for Autoimmune Disease of Gastrointestinal Tract

MalaCards organs/tissues related to Autoimmune Disease of Gastrointestinal Tract:

41
T Cells

Publications for Autoimmune Disease of Gastrointestinal Tract

Variations for Autoimmune Disease of Gastrointestinal Tract

Expression for Autoimmune Disease of Gastrointestinal Tract

Search GEO for disease gene expression data for Autoimmune Disease of Gastrointestinal Tract.

Pathways for Autoimmune Disease of Gastrointestinal Tract

Pathways related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.09 CTLA4 HLA-DQA1 IL15
2 9.47 CBLIF GAST

GO Terms for Autoimmune Disease of Gastrointestinal Tract

Molecular functions related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.62 TGM2 TGM6

Sources for Autoimmune Disease of Gastrointestinal Tract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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