MCID: ATM015
MIFTS: 22

Autoimmune Disease of Gastrointestinal Tract

Categories: Immune diseases, Gastrointestinal diseases

Aliases & Classifications for Autoimmune Disease of Gastrointestinal Tract

MalaCards integrated aliases for Autoimmune Disease of Gastrointestinal Tract:

Name: Autoimmune Disease of Gastrointestinal Tract 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060031

Summaries for Autoimmune Disease of Gastrointestinal Tract

Disease Ontology : 12 A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.

MalaCards based summary : Autoimmune Disease of Gastrointestinal Tract is related to autoimmune hepatitis and celiac disease 1. An important gene associated with Autoimmune Disease of Gastrointestinal Tract is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. Affiliated tissues include t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Disease of Gastrointestinal Tract

Diseases related to Autoimmune Disease of Gastrointestinal Tract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 autoimmune hepatitis 31.3 CD40LG CTLA4 CYP2D6 FTCD SEPSECS
2 celiac disease 1 23.8 CD40LG CD79A CTLA4 HLA-DQA1 IL15 KLRC3
3 gluten allergy 11.1 CD79A TGM2
4 type 1 diabetes mellitus 18 11.0 TNFRSF10A TNFRSF25
5 adie pupil 11.0 TNFRSF25 TOR1A
6 selective igg deficiency disease 11.0 CD40LG CD79A
7 c1q nephropathy 11.0 CD40LG CD79A
8 meningovascular neurosyphilis 11.0 CD40LG CD79A
9 alpha chain disease 11.0 CD40LG CD79A
10 brill-zinsser disease 11.0 CD40LG CD79A
11 exudative glomerulonephritis 11.0 CD40LG CD79A
12 cork-handlers' disease 11.0 CD40LG CD79A
13 salpingo-oophoritis 10.9 CD40LG CD79A
14 early yaws 10.9 CD40LG CD79A
15 ventilation pneumonitis 10.9 CD40LG CD79A
16 chronic interstitial cystitis 10.9 CD40LG CD79A
17 axillary adenitis 10.9 CD40LG CD79A
18 cryofibrinogenemia 10.9 CD40LG CD79A
19 trichostrongyloidiasis 10.9 CD40LG CD79A
20 subacute bacterial endocarditis 10.9 CD40LG CD79A
21 heterophyiasis 10.9 CD40LG CD79A
22 immunoglobulin g deficiency 10.9 CD40LG CD79A
23 orbital granuloma 10.9 CD40LG CD79A
24 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
25 neuronitis 10.9 CD40LG TNFRSF10A
26 juvenile dermatitis herpetiformis 10.9 CD79A TNFRSF25
27 hyperglobulinemic purpura 10.9 CD40LG CD79A
28 gastroduodenitis 10.9 CD40LG CD79A
29 bacterial conjunctivitis 10.9 CD40LG CD79A
30 adult-onset myasthenia gravis 10.9 CTLA4 HLA-DQA1
31 heavy chain disease 10.9 CD40LG CD79A
32 ophthalmia neonatorum 10.9 CD40LG CD79A
33 immunoglobulin a deficiency 1 10.9 CD40LG CD79A
34 wheat allergy 10.9 CD79A TGM2 TOR1A
35 parotid disease 10.9 CD40LG CD79A
36 cerebral arteritis 10.9 CD40LG CD79A
37 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
38 erythema elevatum diutinum 10.8 CD40LG CD79A
39 heart block, congenital 10.8 TNFRSF25 TOR1A
40 sporotrichosis 10.8 CD40LG CD79A
41 spinocerebellar ataxia 35 10.8 TGM2 TGM6
42 fallopian tube disease 10.8 CD40LG CD79A
43 hyperimmunoglobulin syndrome 10.8 CD40LG CD79A
44 type 1 diabetes mellitus 17 10.8 CTLA4 TNFRSF25
45 congenital syphilis 10.8 CD40LG CD79A
46 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A
47 type 1 diabetes mellitus 2 10.8 CTLA4 TNFRSF25
48 monoclonal paraproteinemia 10.8 CD40LG CD79A
49 salpingitis 10.8 CD40LG CD79A
50 ocular toxoplasmosis 10.8 CD40LG CD79A

Graphical network of the top 20 diseases related to Autoimmune Disease of Gastrointestinal Tract:



Diseases related to Autoimmune Disease of Gastrointestinal Tract

Symptoms & Phenotypes for Autoimmune Disease of Gastrointestinal Tract

MGI Mouse Phenotypes related to Autoimmune Disease of Gastrointestinal Tract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 IL15 MYO9B PREP SH2B3 TGM2 TNFRSF10A
2 immune system MP:0005387 9.4 ASGR1 CD40LG CD79A CTLA4 HLA-DQA1 IL15

Drugs & Therapeutics for Autoimmune Disease of Gastrointestinal Tract

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Gastrointestinal Tract

Genetic Tests for Autoimmune Disease of Gastrointestinal Tract

Anatomical Context for Autoimmune Disease of Gastrointestinal Tract

MalaCards organs/tissues related to Autoimmune Disease of Gastrointestinal Tract:

41
T Cells

Publications for Autoimmune Disease of Gastrointestinal Tract

Variations for Autoimmune Disease of Gastrointestinal Tract

Expression for Autoimmune Disease of Gastrointestinal Tract

Search GEO for disease gene expression data for Autoimmune Disease of Gastrointestinal Tract.

Pathways for Autoimmune Disease of Gastrointestinal Tract

GO Terms for Autoimmune Disease of Gastrointestinal Tract

Cellular components related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.23 ASGR1 CD40LG CD79A CTLA4 HLA-DQA1 IL15

Biological processes related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell costimulation GO:0031295 9.13 CD40LG CTLA4 HLA-DQA1
2 immune response GO:0006955 9.1 CD40LG CTLA4 HLA-DQA1 IL15 TNFRSF10A TNFRSF25

Molecular functions related to Autoimmune Disease of Gastrointestinal Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.62 TGM2 TGM6

Sources for Autoimmune Disease of Gastrointestinal Tract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....