MCID: ATM005
MIFTS: 29

Autoimmune Disease of Musculoskeletal System

Categories: Immune diseases, Muscle diseases

Aliases & Classifications for Autoimmune Disease of Musculoskeletal System

MalaCards integrated aliases for Autoimmune Disease of Musculoskeletal System:

Name: Autoimmune Disease of Musculoskeletal System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060032

Summaries for Autoimmune Disease of Musculoskeletal System

Disease Ontology : 12 An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system.

MalaCards based summary : Autoimmune Disease of Musculoskeletal System is related to juvenile ankylosing spondylitis and cystitis. An important gene associated with Autoimmune Disease of Musculoskeletal System is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include bone, heart and lung.

Related Diseases for Autoimmune Disease of Musculoskeletal System

Diseases related to Autoimmune Disease of Musculoskeletal System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 770)
# Related Disease Score Top Affiliating Genes
1 juvenile ankylosing spondylitis 11.2
2 cystitis 10.7 TNF IL6 IL17A CRP
3 progressive relapsing multiple sclerosis 10.7 SERPINA3 H2AC18 CFHR2 CCR6
4 physiological polycythemia 10.7 TNF IL6 IL1B
5 uveitis 10.7 TNF IL6 IL1B IL17A
6 dacryoadenitis 10.6 IL17A ICOSLG CD4 CCR6
7 dermatomyositis 10.6 MIR34A MIR223 MIR21 MIR155
8 purpura 10.6 TNF IL6 CRP
9 immunodeficiency with hyper-igm, type 1 10.6 ICOSLG H2AC18 CD4 CCR6
10 sialadenitis 10.6 TNF ICOSLG CD4 CCR6
11 suppurative lymphadenitis 10.6 CRP CD4 CCR6
12 thymus gland disease 10.6 MIR125A ICOSLG H2AC18 CD4 CCR6
13 thymus cancer 10.6 MIR125A ICOSLG H2AC18 CD4 CCR6
14 castleman disease 10.6 IL6 H2AC18 CRP CD4
15 immune-complex glomerulonephritis 10.6 ICOSLG H2AC18 CFHR2 CD4
16 anti-basement membrane glomerulonephritis 10.6 CFHR2 CD4 CCR6
17 posterior uveitis 10.6 TNF IL6 ICOSLG CCR6
18 pre-malignant neoplasm 10.6 SERPINA3 MIR142 H2AC18 CCR6
19 aspiration pneumonitis 10.6 TNF SERPINA3 CRP
20 mikulicz disease 10.6 CRP CD4 CCR6
21 skeletal tuberculosis 10.6 TNF CRP CFHR2
22 toxic megacolon 10.6 TNF CRP CCR6
23 rheumatoid arthritis interstitial lung disease 10.6 TNF CRP CD4
24 chromosomal deletion syndrome 10.6 MIR223 MIR142 ICOSLG H2AC18 CCR6
25 thrombocytopenia due to platelet alloimmunization 10.6 IL17A ICOSLG CD4 CCR6
26 teeth hard tissue disease 10.6 SERPINA3 IL6 H2AC18 CCR6
27 spondyloarthropathy 10.6 TNF IL6 IL1B IL17A
28 pustulosis of palm and sole 10.6 TNF IL17A CRP CCR6
29 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.6 IL17A ICOSLG H2AC18 CD4 CCR6
30 progressive multifocal leukoencephalopathy 10.6 TNF ICOSLG CD4 CCR6
31 blastomycosis 10.6 IL6 IL17A CD4 CCR6
32 esophageal candidiasis 10.6 IL17A CD4 CCR6
33 combat disorder 10.6 TNF SERPINA3 IL6 CD4
34 arthropathy 10.6 TNF IL6 IL1B CRP
35 t cell deficiency 10.6 IL17A ICOSLG CD4 CCR6
36 childhood type dermatomyositis 10.6 TNF IL6 ICOSLG CD4 CCR6
37 farmer's lung 10.6 TNF SERPINA3 IL17A CD4
38 henoch-schoenlein purpura 10.6 SERPINA3 ICOSLG CRP CFHR2
39 palladium allergic contact dermatitis 10.6 TNF IL1B IL17A
40 dental pulp disease 10.6 TNF IL6 IL1B CCR6
41 opportunistic bacterial infectious disease 10.6 TNF CRP CD4
42 subcutaneous mycosis 10.6 IL17A CD4 CCR6
43 herpes zoster 10.6 TNF ICOSLG CD4 CCR6
44 synovitis 10.6 TNF IL6 IL1B CRP
45 vasculitis 10.6 TNF SERPINA3 IL6 IL17A CRP
46 legume allergy 10.6 ICOSLG CD4 CCR6
47 ulcer of lower limbs 10.6 TNF IL6 IL1B
48 fruit allergy 10.6 ICOSLG CD4 CCR6
49 intestinal schistosomiasis 10.6 TNF IL17A ICOSLG CD4 CCR6
50 hyper ige recurrent infection syndrome 1 10.6 IL6 IL17A CD4 CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of Musculoskeletal System:



Diseases related to Autoimmune Disease of Musculoskeletal System

Symptoms & Phenotypes for Autoimmune Disease of Musculoskeletal System

Drugs & Therapeutics for Autoimmune Disease of Musculoskeletal System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Musculoskeletal System

Genetic Tests for Autoimmune Disease of Musculoskeletal System

Anatomical Context for Autoimmune Disease of Musculoskeletal System

MalaCards organs/tissues related to Autoimmune Disease of Musculoskeletal System:

40
Bone, Heart, Lung, Skin, T Cells, Liver, Eye

Publications for Autoimmune Disease of Musculoskeletal System

Variations for Autoimmune Disease of Musculoskeletal System

Expression for Autoimmune Disease of Musculoskeletal System

Search GEO for disease gene expression data for Autoimmune Disease of Musculoskeletal System.

Pathways for Autoimmune Disease of Musculoskeletal System

Pathways related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 TNF IL6 IL1B IL17A ICOSLG CD4
2
Show member pathways
12.54 TNF IL6 IL1B IL17A CD4
3
Show member pathways
12.53 TNF IL6 IL1B IL17A CD4
4
Show member pathways
12.52 TNF IL6 IL1B IL17A CD4
5
Show member pathways
12.28 TNF IL6 IL1B IL17A
6
Show member pathways
12.19 TNF SERPINA3 IL6 IL1B CRP
7 12.06 TNF MIR21 MIR125A IL1B
8 12.01 TNF IL6 IL1B CD4
9 11.88 TNF IL6 IL1B IL17A
10 11.81 TNF IL6 IL1B CD4
11 11.76 TNF IL6 IL1B IL17A
12
Show member pathways
11.74 IL6 IL1B IL17A CD4
13 11.71 TNF IL6 IL1B
14 11.66 MIR34A MIR223 MIR21 MIR155 MIR146A MIR126
15
Show member pathways
11.61 TNF IL6 IL1B
16 11.61 TNF IL6 IL1B
17 11.57 TNF IL6 IL1B CD4
18 11.56 TNF IL6 IL1B
19 11.5 TNF IL6 IL1B
20 11.49 TNF IL6 ICOSLG CCR6
21 11.48 TNF IL6 IL1B
22 11.46 TNF IL1B IL17A CD4 CCR6
23 11.44 TNF IL6 IL1B
24 11.31 TNF IL6 IL1B
25 11.28 TNF IL6 IL1B
26
Show member pathways
11.23 TNF IL6 IL1B IL17A CD4
27 11.22 TNF IL6 IL1B
28 11.13 TNF IL6 IL1B IL17A
29 11.02 TNF IL6 IL1B CD4
30 10.89 TNF IL6 CRP
31 10.6 TNF MIR126

GO Terms for Autoimmune Disease of Musculoskeletal System

Cellular components related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 SERPINA3 MIR34A MIR223 MIR21 MIR155 MIR146A
2 external side of plasma membrane GO:0009897 9.55 TNF IL17A ICOSLG CD4 CCR6
3 extracellular space GO:0005615 9.47 TNF SERPINA3 MIR223 MIR21 MIR155 MIR146A
4 extracellular vesicle GO:1903561 9.26 MIR34A MIR21 MIR126 MIR125A

Biological processes related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.11 CCR6 CD4 IL17A IL1B IL6 TNF
2 inflammatory response GO:0006954 10.08 CRP IL17A IL1B IL6 SERPINA3 TNF
3 cytokine-mediated signaling pathway GO:0019221 10.04 TNF IL6 IL1B IL17A CD4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.01 TNF MIR21 MIR126 CD4
5 positive regulation of protein phosphorylation GO:0001934 10 TNF MIR21 IL1B CD4
6 negative regulation of inflammatory response GO:0050728 9.97 MIR223 MIR126 MIR142 MIR146A MIR155
7 cellular response to hypoxia GO:0071456 9.97 MIR126 MIR140 MIR146A MIR155 MIR34A
8 negative regulation of angiogenesis GO:0016525 9.95 MIR34A MIR21 MIR146A MIR125A
9 defense response to Gram-positive bacterium GO:0050830 9.92 CRP IL17A IL6 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.91 IL17A IL1B IL6 TNF
11 regulation of insulin secretion GO:0050796 9.88 TNF IL6 IL1B
12 positive regulation of T cell proliferation GO:0042102 9.88 IL6 IL1B CD4
13 positive regulation of inflammatory response GO:0050729 9.88 IL1B MIR126 MIR155 MIR21 TNF
14 cellular response to lipopolysaccharide GO:0071222 9.88 IL1B IL6 MIR140 MIR146A MIR21 TNF
15 positive regulation of interleukin-8 production GO:0032757 9.87 TNF IL6 IL1B
16 humoral immune response GO:0006959 9.87 TNF IL6 CCR6
17 negative regulation of gene expression GO:0010629 9.87 MIR125A MIR140 MIR146A MIR155 MIR21 MIR34A
18 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 IL17A
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.85 MIR21 IL6 IL1B
20 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.85 MIR34A MIR223 MIR140
21 cellular response to virus GO:0098586 9.85 MIR21 MIR146A IL6
22 negative regulation of endothelial cell proliferation GO:0001937 9.84 TNF MIR21 MIR146A
23 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.83 MIR223 MIR21 MIR146A
24 acute-phase response GO:0006953 9.83 SERPINA3 IL6 CRP
25 positive regulation of sprouting angiogenesis GO:1903672 9.81 MIR125A MIR126 MIR155
26 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.81 MIR125A MIR140 MIR146A MIR155
27 positive regulation of activated T cell proliferation GO:0042104 9.8 ICOSLG MIR155 MIR21
28 negative regulation of neurogenesis GO:0050768 9.79 IL1B IL6 TNF
29 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.79 MIR126 MIR146A MIR21
30 positive regulation of glial cell proliferation GO:0060252 9.77 IL1B IL6 TNF
31 negative regulation of interleukin-6 production GO:0032715 9.77 MIR125A MIR140 MIR146A MIR155 TNF
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.76 IL6 MIR21 TNF
33 negative regulation of vascular endothelial growth factor production GO:1904046 9.76 MIR125A MIR140 MIR146A MIR34A
34 negative regulation of lipid storage GO:0010888 9.73 CRP IL6 TNF
35 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.73 IL17A IL6 MIR21 TNF
36 negative regulation of vascular wound healing GO:0061044 9.72 MIR155 MIR34A TNF
37 negative regulation of amyloid-beta clearance GO:1900222 9.71 TNF MIR34A
38 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
39 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.71 MIR125A MIR146A MIR155
40 negative regulation of regulatory T cell differentiation GO:0045590 9.7 MIR21 MIR155
41 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.7 MIR21 IL6
42 negative regulation of bicellular tight junction assembly GO:1903347 9.7 MIR142 MIR155 TNF
43 negative regulation of necrotic cell death GO:0060547 9.68 MIR223 MIR155
44 positive regulation of fever generation GO:0031622 9.68 TNF IL1B
45 negative regulation of intracellular signal transduction GO:1902532 9.67 MIR34A MIR146A
46 sequestering of triglyceride GO:0030730 9.67 TNF IL1B
47 vascular endothelial growth factor production GO:0010573 9.67 IL1B IL6 TNF
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 TNF IL1B
49 gene silencing by miRNA GO:0035195 9.61 MIR125A MIR126 MIR140 MIR142 MIR146A MIR155
50 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.56 MIR140 MIR21 MIR223 MIR34A

Molecular functions related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 TNF IL6 IL1B IL17A
2 mRNA 3'-UTR binding GO:0003730 9.5 MIR34A MIR21 MIR146A MIR142 MIR140 MIR126
3 RNA polymerase II complex binding GO:0000993 9.33 MIR140 MIR126 MIR125A
4 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.28 MIR34A MIR223 MIR21 MIR155 MIR146A MIR142

Sources for Autoimmune Disease of Musculoskeletal System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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