MCID: ATM005
MIFTS: 32

Autoimmune Disease of Musculoskeletal System

Categories: Immune diseases, Muscle diseases

Aliases & Classifications for Autoimmune Disease of Musculoskeletal System

MalaCards integrated aliases for Autoimmune Disease of Musculoskeletal System:

Name: Autoimmune Disease of Musculoskeletal System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060032

Summaries for Autoimmune Disease of Musculoskeletal System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system.

MalaCards based summary : Autoimmune Disease of Musculoskeletal System is related to juvenile ankylosing spondylitis and viral exanthem. An important gene associated with Autoimmune Disease of Musculoskeletal System is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include t cells, lung and skin, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Disease of Musculoskeletal System

Diseases related to Autoimmune Disease of Musculoskeletal System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 juvenile ankylosing spondylitis 32.3 IL6 TNF
2 viral exanthem 10.4 APOH TLR9
3 erythema infectiosum 10.4 APOH TLR9
4 cardiogenic shock 10.4 IL6 TNF
5 streptococcal toxic-shock syndrome 10.4 IL6 TNF
6 lichen planus pemphigoides 10.4 COL17A1 DST
7 punctate inner choroidopathy 10.4 IL10 TNF
8 herpes gestationis 10.4 COL17A1 DST TNFRSF25
9 scorpion envenomation 10.3 IL6 TNF
10 autoimmune disease of skin and connective tissue 10.3 COL17A1 DST TNFRSF25
11 tropical endomyocardial fibrosis 10.3 IL10 TNF
12 pemphigoid gestationis 10.3 COL17A1 DST
13 endomyocardial fibrosis 10.3 IL10 TNF
14 vasculitis 10.3 APOH TNF TNFSF13B
15 cellulitis 10.3 COL17A1 DST TNF
16 facial hemiatrophy 10.3 COL17A1 SNRNP70 TRIM21
17 diffuse scleroderma 10.3 TNFRSF25 TOP1 TRIM21
18 myelitis 10.3 APOH IL6 TNF
19 mucocutaneous leishmaniasis 10.3 IL10 TLR9 TNF
20 cutaneous leishmaniasis 10.3 IL10 TLR9 TNF
21 central nervous system vasculitis 10.3 IL6 TLR9 TNF
22 eye lymphoma 10.3 IL10 IL6 TLR9
23 chronic graft versus host disease 10.3 IL10 TNF TNFSF13B
24 middle ear disease 10.3 IL6 TLR9 TNF
25 coccidiosis 10.3 IL10 TLR9 TNF
26 cogan syndrome 10.3 TNF TRIM21 TROVE2
27 subacute cutaneous lupus erythematosus 10.3 TNF TRIM21
28 perinatal necrotizing enterocolitis 10.3 IL6 TLR9 TNF
29 superficial basal cell carcinoma 10.3 TLR7 TLR9
30 interstitial lung disease 10.3 IL10 IL6 TNF
31 cutaneous lupus erythematosus 10.3 TNF TRIM21 TROVE2
32 lichen disease 10.3 COL17A1 DST TLR9 TNF
33 leukomalacia 10.3 IL6 TNF
34 opportunistic mycosis 10.3 IL10 TLR9 TNF
35 nose disease 10.3 IL10 TLR9 TNF
36 spinal cord disease 10.3 DDX41 IL6 TNF
37 infective endocarditis 10.3 APOH IL6 TNF
38 placenta disease 10.3 APOH IL6 TLR9
39 lichen planus 10.3 COL17A1 DST TLR9 TNF
40 parasitic helminthiasis infectious disease 10.3 IL10 TLR9 TNF
41 autoimmune atherosclerosis 10.3 APOH IL10
42 epstein-barr virus-associated gastric carcinoma 10.3 IL10 IRF5 TNF
43 tonsillitis 10.3 IL6 TLR9 TNF
44 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
45 neuromuscular junction disease 10.3 DDX41 MUSK TLR9 TNFRSF25
46 dry eye syndrome 10.3 IL6 TLR9 TNF
47 autoimmune gastritis 10.3 IL10 IL6 TNF
48 limited scleroderma 10.3 IRF5 SNRNP70 TOP1
49 temporal arteritis 10.3 APOH IL6 TNF
50 intermediate uveitis 10.3 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Autoimmune Disease of Musculoskeletal System:



Diseases related to Autoimmune Disease of Musculoskeletal System

Symptoms & Phenotypes for Autoimmune Disease of Musculoskeletal System

MGI Mouse Phenotypes related to Autoimmune Disease of Musculoskeletal System:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 C3 IL10 IL6 IRF5 SSB TLR7
2 immune system MP:0005387 9.73 C3 IL10 IL6 IRF5 SSB TLR7
3 mortality/aging MP:0010768 9.47 APOH C3 DDX41 IL10 IL6 MUSK

Drugs & Therapeutics for Autoimmune Disease of Musculoskeletal System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Musculoskeletal System

Genetic Tests for Autoimmune Disease of Musculoskeletal System

Anatomical Context for Autoimmune Disease of Musculoskeletal System

MalaCards organs/tissues related to Autoimmune Disease of Musculoskeletal System:

41
T Cells, Lung, Skin, Bone, Heart, Lymph Node, Eye

Publications for Autoimmune Disease of Musculoskeletal System

Variations for Autoimmune Disease of Musculoskeletal System

Expression for Autoimmune Disease of Musculoskeletal System

Search GEO for disease gene expression data for Autoimmune Disease of Musculoskeletal System.

Pathways for Autoimmune Disease of Musculoskeletal System

Pathways related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 C3 DDX41 IL10 IL6 IRF5 TLR7
2
Show member pathways
13.28 IL10 IL6 IRF5 TNF TNFRSF25 TNFSF13B
3
Show member pathways
13.26 IL10 IL6 MUSK TLR7 TLR9 TNF
4
Show member pathways
12.83 C3 IL10 IL6 IRF5 TLR7 TLR9
5
Show member pathways
12.7 C3 IL6 TLR7 TLR9 TNF
6
Show member pathways
12.61 IL6 TLR7 TLR9 TNF TNFSF13B
7
Show member pathways
12.53 TLR7 TLR9 TNF TNFRSF25 TNFSF13B
8
Show member pathways
12.16 IL6 TLR7 TLR9 TNF
9
Show member pathways
12.1 IL10 IL6 TLR9 TNF
10
Show member pathways
12.05 IL6 TLR7 TLR9 TNF
11 12.04 IL6 TLR7 TLR9 TNF
12 12.02 C3 IL10 IL6 TLR9 TNF
13 12.01 IL10 IRF5 TLR7 TLR9 TNF TNFRSF25
14 11.8 IL10 IL6 TNF
15 11.77 IL6 TNF TNFSF13B
16
Show member pathways
11.77 IL10 IL6 TLR7 TLR9 TNF
17 11.73 C3 TLR7 TLR9
18
Show member pathways
11.65 TNF TNFRSF25 TNFSF13B
19 11.63 IL10 IL6 TNF
20 11.59 C3 IL10 IL6 TNF
21 11.48 C3 IL6 TNF
22 11.41 IL10 IL6 TNF
23 11.31 IL10 IL6 TLR9 TNF
24 11.2 IL10 IL6 TNF
25 11.11 IL10 IL6 TNF TNFSF13B
26 11.1 IL10 IL6 TNF
27 11 IL10 IL6 TLR9 TNF
28 10.89 IL10 IL6 TLR7 TLR9 TNF
29 10.87 COL17A1 IL10 IL6 MUSK TNF TNFSF13B

GO Terms for Autoimmune Disease of Musculoskeletal System

Cellular components related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 APOH C3 COL17A1 IL10 IL6 TLR9
2 endolysosome membrane GO:0036020 9.26 TLR7 TLR9
3 early phagosome GO:0032009 8.96 TLR7 TLR9
4 hemidesmosome GO:0030056 8.62 COL17A1 DST

Biological processes related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.96 IL10 IL6 IRF5 TNF
2 inflammatory response GO:0006954 9.85 C3 IL10 IL6 TLR7 TLR9 TNF
3 positive regulation of inflammatory response GO:0050729 9.79 TLR7 TLR9 TNF
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.78 TNF TNFRSF25 TNFSF13B
5 response to glucocorticoid GO:0051384 9.77 IL10 IL6 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.76 IL10 IL6 TNF TRIM21
7 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.75 TLR7 TLR9 TNF
8 defense response to virus GO:0051607 9.72 DDX41 IL6 IRF5 TLR7 TLR9
9 immune response GO:0006955 9.7 C3 IL10 IL6 TLR7 TLR9 TNF
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.69 TLR7 TLR9 TNF
11 negative regulation of growth of symbiont in host GO:0044130 9.65 IL10 TNF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 TNF
13 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.64 TLR7 TLR9
14 hemidesmosome assembly GO:0031581 9.63 COL17A1 DST
15 I-kappaB phosphorylation GO:0007252 9.63 TLR7 TLR9
16 response to molecule of bacterial origin GO:0002237 9.62 IL10 TLR9
17 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
18 negative regulation of interleukin-6 production GO:0032715 9.61 IL10 TLR9 TNF
19 endothelial cell apoptotic process GO:0072577 9.59 IL10 TNF
20 positive regulation of interferon-beta biosynthetic process GO:0045359 9.58 TLR7 TLR9
21 positive regulation of interleukin-8 production GO:0032757 9.58 TLR7 TLR9 TNF
22 negative regulation of interleukin-8 production GO:0032717 9.56 IL10 TLR9
23 positive regulation of interleukin-6 production GO:0032755 9.56 IL6 TLR7 TLR9 TNF
24 response to peptidoglycan GO:0032494 9.55 IL6 IRF5
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.54 IL10 TNF
26 positive regulation of neuroinflammatory response GO:0150078 9.52 IL6 TNF
27 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.49 TLR7 TLR9
28 receptor biosynthetic process GO:0032800 9.48 IL10 TNF
29 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.13 TLR7 TLR9 TNF
30 positive regulation of chemokine production GO:0032722 8.92 IL6 TLR7 TLR9 TNF
31 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 DDX41 IL10 IL6 IRF5 TLR9 TNF
32 innate immune response GO:0045087 10.04 C3 IRF5 TLR7 TLR9 TRIM21

Molecular functions related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling pattern recognition receptor activity GO:0008329 9.16 TLR7 TLR9
2 siRNA binding GO:0035197 8.96 TLR7 TLR9
3 cytokine activity GO:0005125 8.92 IL10 IL6 TNF TNFSF13B

Sources for Autoimmune Disease of Musculoskeletal System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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