MCID: ATM005
MIFTS: 28

Autoimmune Disease of Musculoskeletal System

Categories: Immune diseases, Muscle diseases

Aliases & Classifications for Autoimmune Disease of Musculoskeletal System

MalaCards integrated aliases for Autoimmune Disease of Musculoskeletal System:

Name: Autoimmune Disease of Musculoskeletal System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060032

Summaries for Autoimmune Disease of Musculoskeletal System

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system.

MalaCards based summary : Autoimmune Disease of Musculoskeletal System is related to juvenile ankylosing spondylitis and lichen planus pemphigoides. An important gene associated with Autoimmune Disease of Musculoskeletal System is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include t cells, eye and skin, and related phenotype is hematopoietic system.

Related Diseases for Autoimmune Disease of Musculoskeletal System

Diseases related to Autoimmune Disease of Musculoskeletal System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 juvenile ankylosing spondylitis 32.2 IL6 TNF
2 lichen planus pemphigoides 10.6 COL17A1 DST
3 pemphigoid gestationis 10.5 COL17A1 DST
4 diffuse cutaneous systemic sclerosis 10.5 CCR6 ICOSLG IRF5
5 scorpion envenomation 10.5 IL6 TNF
6 sialadenitis 10.5 TNF TNFSF13B TRIM21
7 subacute cutaneous lupus erythematosus 10.5 TNF TRIM21
8 vasculitis 10.5 APOH TNF TNFSF13B
9 autoimmune disease of skin and connective tissue 10.5 COL17A1 DST TNFRSF25
10 cellulitis 10.5 COL17A1 DST TNF
11 facial hemiatrophy 10.5 COL17A1 SNRNP70 TRIM21
12 heart block, congenital 10.5 DDX41 TNFRSF25 TRIM21
13 diffuse scleroderma 10.5 TNFRSF25 TOP1 TRIM21
14 leukomalacia 10.5 IL6 TNF
15 stromal keratitis 10.5 CCR6 IL6 TNF
16 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
17 superficial basal cell carcinoma 10.5 TLR7 TLR9
18 transverse myelitis 10.5 APOH IL6 TNF
19 myelitis 10.5 APOH IL6 TNF
20 viral encephalitis 10.5 IL6 TNF TNFSF13B
21 spinal cord disease 10.5 DDX41 IL6 TNF
22 bacterial infectious disease 10.5 IL6 TLR9 TNF
23 infective endocarditis 10.5 APOH IL6 TNF
24 endocarditis 10.5 APOH IL6 TNF
25 central nervous system vasculitis 10.5 IL6 TLR9 TNF
26 temporal arteritis 10.5 APOH IL6 TNF
27 autoimmune disease of eyes, ear, nose and throat 10.5 IL6 TLR9 TNF
28 sudden sensorineural hearing loss 10.5 APOH IL6
29 hypersensitivity reaction type iii disease 10.5 IL6 TLR9 TNF
30 autoimmune myocarditis 10.5 IL6 TNF
31 linear iga disease 10.5 COL17A1 DST
32 bullous pemphigoid 10.5 COL17A1 DST TNFSF13B
33 middle ear disease 10.5 IL6 TLR9 TNF
34 perinatal necrotizing enterocolitis 10.4 IL6 TLR9 TNF
35 adie pupil 10.4 TNFRSF25 TRIM21
36 keratoconjunctivitis sicca 10.4 IL6 TLR9 TNF
37 extrinsic cardiomyopathy 10.4 IL6 TLR9 TNF
38 lymph node disease 10.4 IL6 TLR9 TNF
39 uveal disease 10.4 IL6 TLR9 TNF
40 placenta disease 10.4 APOH IL6 TLR9
41 human immunodeficiency virus infectious disease 10.4 IL6 TLR9 TNF
42 tonsillitis 10.4 IL6 TLR9 TNF
43 dry eye syndrome 10.4 IL6 TLR9 TNF
44 parasitic protozoa infectious disease 10.4 IL6 TLR9 TNF
45 lichen disease 10.4 COL17A1 DST TLR9 TNF
46 filariasis 10.4 IL6 TLR9 TNF
47 purpura 10.4 APOH IL6 TNF
48 autoimmune disease of central nervous system 10.4 IL6 TLR9 TNF
49 lichen planus 10.4 COL17A1 DST TLR9 TNF
50 bacterial meningitis 10.4 IL6 TLR9 TNF

Graphical network of the top 20 diseases related to Autoimmune Disease of Musculoskeletal System:



Diseases related to Autoimmune Disease of Musculoskeletal System

Symptoms & Phenotypes for Autoimmune Disease of Musculoskeletal System

MGI Mouse Phenotypes related to Autoimmune Disease of Musculoskeletal System:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.32 CCR6 IL6 IRF5 SSB TLR7 TLR9

Drugs & Therapeutics for Autoimmune Disease of Musculoskeletal System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Musculoskeletal System

Genetic Tests for Autoimmune Disease of Musculoskeletal System

Anatomical Context for Autoimmune Disease of Musculoskeletal System

MalaCards organs/tissues related to Autoimmune Disease of Musculoskeletal System:

42
T Cells, Eye, Skin, Bone, Heart, Lymph Node, Spinal Cord

Publications for Autoimmune Disease of Musculoskeletal System

Variations for Autoimmune Disease of Musculoskeletal System

Expression for Autoimmune Disease of Musculoskeletal System

Search GEO for disease gene expression data for Autoimmune Disease of Musculoskeletal System.

Pathways for Autoimmune Disease of Musculoskeletal System

Pathways related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 CCR6 DDX41 ICOSLG IL6 IRF5 TLR7
2
Show member pathways
13.07 CCR6 IL6 MUSK TLR7 TLR9 TNF
3
Show member pathways
12.5 IL6 TLR7 TLR9 TNF TNFSF13B
4
Show member pathways
12.42 TLR7 TLR9 TNF TNFRSF25 TNFSF13B
5
Show member pathways
12.04 IL6 TLR7 TLR9 TNF
6
Show member pathways
11.92 IL6 TLR7 TLR9 TNF
7 11.89 IL6 TLR7 TLR9 TNF
8 11.67 IL6 TNF TNFSF13B
9
Show member pathways
11.67 IL6 TLR7 TLR9 TNF
10 11.61 IRF5 TLR7 TLR9 TNF TNFRSF25 TNFSF13B
11
Show member pathways
11.55 TNF TNFRSF25 TNFSF13B
12 11.3 IL6 TLR9 TNF
13 11.13 IL6 TLR7 TLR9 TNF
14 10.9 IL6 TLR9 TNF
15 10.85 COL17A1 IL6 MUSK TNF TNFSF13B

GO Terms for Autoimmune Disease of Musculoskeletal System

Cellular components related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endolysosome membrane GO:0036020 9.16 TLR7 TLR9
2 early phagosome GO:0032009 8.96 TLR7 TLR9
3 hemidesmosome GO:0030056 8.62 COL17A1 DST

Biological processes related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 CCR6 IL6 TLR7 TLR9 TNF TNFSF13B
2 positive regulation of inflammatory response GO:0050729 9.73 TLR7 TLR9 TNF
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.71 TNF TNFRSF25 TNFSF13B
4 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.69 TLR7 TLR9 TNF
5 humoral immune response GO:0006959 9.65 CCR6 IL6 TNF
6 defense response to virus GO:0051607 9.65 DDX41 IL6 IRF5 TLR7 TLR9
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.61 TLR7 TLR9 TNF
8 toll-like receptor 9 signaling pathway GO:0034162 9.59 TLR7 TLR9
9 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.58 TLR7 TLR9
10 hemidesmosome assembly GO:0031581 9.58 COL17A1 DST
11 I-kappaB phosphorylation GO:0007252 9.57 TLR7 TLR9
12 negative regulation of lipid storage GO:0010888 9.55 IL6 TNF
13 positive regulation of interferon-beta biosynthetic process GO:0045359 9.52 TLR7 TLR9
14 positive regulation of interleukin-8 production GO:0032757 9.5 TLR7 TLR9 TNF
15 response to peptidoglycan GO:0032494 9.49 IL6 IRF5
16 positive regulation of neuroinflammatory response GO:0150078 9.46 IL6 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.46 IL6 TLR7 TLR9 TNF
18 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.4 TLR7 TLR9
19 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.13 TLR7 TLR9 TNF
20 positive regulation of chemokine production GO:0032722 8.92 IL6 TLR7 TLR9 TNF
21 immune system process GO:0002376 10 ICOSLG IRF5 TLR7 TLR9 TNFSF13B

Molecular functions related to Autoimmune Disease of Musculoskeletal System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling pattern recognition receptor activity GO:0008329 8.96 TLR7 TLR9
2 siRNA binding GO:0035197 8.62 TLR7 TLR9

Sources for Autoimmune Disease of Musculoskeletal System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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