Autoimmune Disease of Peripheral Nervous System disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ATM105 MIFTS: 27	Autoimmune Disease of Peripheral Nervous System Categories: Immune diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

Sources

Aliases & Classifications for Autoimmune Disease of Peripheral Nervous System

MalaCards integrated aliases for Autoimmune Disease of Peripheral Nervous System:

Name: Autoimmune Disease of Peripheral Nervous System ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060033

Sources

Summaries for Autoimmune Disease of Peripheral Nervous System

Disease Ontology : ¹² An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.

MalaCards based summary : Autoimmune Disease of Peripheral Nervous System is related to autoimmune peripheral neuropathy and guillain-barre syndrome. An important gene associated with Autoimmune Disease of Peripheral Nervous System is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Th17 Differentiation Pathway and Spinal Cord Injury. Affiliated tissues include t cells, skin and bone, and related phenotypes are behavior/neurological and growth/size/body region

Sources

Related Diseases for Autoimmune Disease of Peripheral Nervous System

Diseases in the Peripheral Nervous System Disease family:

Autoimmune Disease of Peripheral Nervous System

Diseases related to Autoimmune Disease of Peripheral Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)

#	Related Disease	Score	Top Affiliating Genes
1	autoimmune peripheral neuropathy	32.4	MAG ICOSLG CD4
2	guillain-barre syndrome	32.4	MOG MBP IL17A
3	chronic inflammatory demyelinating polyradiculoneuropathy	32.3	MBP IL17A IFNB1 ICOSLG
4	autoimmune optic neuritis	32.2	MOG MBP KCNJ10 DPYSL5 AQP4
5	allergic encephalomyelitis	10.5	MOG MBP
6	paraneoplastic polyneuropathy	10.4	MAG AMPH
7	acute retrobulbar neuritis	10.4	MBP AQP4
8	central pontine myelinolysis	10.4	MBP MAG AQP4
9	abducens nerve disease	10.4	MUSK AQP4
10	partial optic atrophy	10.4	DPYSL5 AMPH
11	chorea gravidarum	10.4	DPYSL5 CNTNAP2
12	color agnosia	10.4	MBP CNTNAP2 AQP4
13	optic papillitis	10.4	MOG CD4 AQP4
14	post-vaccinal encephalitis	10.4	MBP ICOSLG
15	acute transverse myelitis	10.4	IL6 AQP4
16	herpes simplex virus keratitis	10.4	IFNB1 CD4 CCR6
17	cerebellopontine angle tumor	10.4	DPYSL5 CNTNAP2
18	legume allergy	10.4	ICOSLG CD4 CCR6
19	fruit allergy	10.4	ICOSLG CD4 CCR6
20	autoimmune encephalitis	10.4	LGI1 CNTNAP2
21	immunodeficiency 16	10.4	ICOSLG CD4 CCR6
22	autoimmune glomerulonephritis	10.4	ICOSLG CD4 CCR6
23	balo concentric sclerosis	10.4	MOG MBP IFNB1 AQP4
24	postinfectious encephalitis	10.4	MBP LGI1 CNTNAP2
25	primary thrombocytopenia	10.4	ICOSLG CD4 CCR6
26	retinal vasculitis	10.4	IFNB1 CD4 CCR6
27	suppurative lymphadenitis	10.4	CD4 CCR6
28	sialadenitis	10.4	ICOSLG CD4 CCR6
29	anogenital venereal wart	10.4	IFNB1 CD4 CCR6
30	osteosclerotic myeloma	10.4	MAG IL6
31	immunoglobulin alpha deficiency	10.4	ICOSLG CD4 CCR6
32	anemia, autoimmune hemolytic	10.4	ICOSLG CD4 CCR6
33	nasopharyngitis	10.4	IL17A IFNB1 CCR6
34	dissociative amnesia	10.4	LGI1 CNTNAP2
35	respiratory allergy	10.4	ICOSLG CD4 CCR6
36	traumatic brain injury	10.4	MBP IL6 AQP4
37	brain injury	10.4	MBP IL6 AQP4
38	bullous skin disease	10.4	ICOSLG CD4 CCR6
39	primary progressive multiple sclerosis	10.4	MOG MBP IFNB1
40	immunodeficiency with hyper-igm, type 1	10.4	ICOSLG CD4 CCR6
41	vascular myelopathy	10.4	MOG DPYSL5 AQP4 AMPH
42	arachnoiditis	10.4	CD4 AQP4
43	thrombocytopenic purpura, autoimmune	10.4	ICOSLG CD4 CCR6
44	anal spasm	10.3	DPYSL5 CD4 AMPH
45	lambert-eaton myasthenic syndrome	10.3	SOX1 MUSK AMPH
46	agammaglobulinemia, x-linked	10.3	ICOSLG CD4 CCR6
47	herpes zoster	10.3	ICOSLG CD4 CCR6
48	neuroretinitis	10.3	DPYSL5 CD4
49	esophageal candidiasis	10.3	IL17A CD4 CCR6
50	subcutaneous mycosis	10.3	IL17A CD4 CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of Peripheral Nervous System:

Sources

Symptoms & Phenotypes for Autoimmune Disease of Peripheral Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Peripheral Nervous System:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10	AMPH AQP4 CNTN1 CNTNAP2 DPYSL5 IL6
2	growth/size/body region	MP:0005378	9.8	AQP4 CD4 CNTN1 CNTNAP2 IL17A IL6
3	nervous system	MP:0003631	9.55	AMPH AQP4 CCR6 CD4 CNTN1 CNTNAP2

Sources

Drugs & Therapeutics for Autoimmune Disease of Peripheral Nervous System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Peripheral Nervous System

Sources

Genetic Tests for Autoimmune Disease of Peripheral Nervous System

Sources

Anatomical Context for Autoimmune Disease of Peripheral Nervous System

MalaCards organs/tissues related to Autoimmune Disease of Peripheral Nervous System:

⁴⁰

T Cells, Skin, Bone, Thymus, Brain, Bone Marrow, Eye

Sources

Publications for Autoimmune Disease of Peripheral Nervous System

Articles related to Autoimmune Disease of Peripheral Nervous System:

#	Title	Authors	PMID	Year
1	Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system. ⁶¹	Abbas N...Zhu J	11078155	2000

Sources

Genes for Autoimmune Disease of Peripheral Nervous System

Genes related to Autoimmune Disease of Peripheral Nervous System (0 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AQP4	Aquaporin 4	Protein Coding	10.71	DISEASES inferred ¹⁵
2	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.46	DISEASES inferred ¹⁵ ¹⁵
3	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	9.32	DISEASES inferred ¹⁵
4	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.32	DISEASES inferred ¹⁵ ¹⁵
5	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	7.58	DISEASES inferred ¹⁵
6	IFNB1	Interferon Beta 1	Protein Coding	7.52	DISEASES inferred ¹⁵
7	MAG	Myelin Associated Glycoprotein	Protein Coding	7.49	DISEASES inferred ¹⁵
8	MBP	Myelin Basic Protein	Protein Coding	7.48	DISEASES inferred ¹⁵
9	NFASC	Neurofascin	Protein Coding	7.44	DISEASES inferred ¹⁵
10	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	7.37	DISEASES inferred ¹⁵
11	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	7.25	DISEASES inferred ¹⁵
12	AMPH	Amphiphysin	Protein Coding	7.1	DISEASES inferred ¹⁵
13	SOX1	SRY-Box Transcription Factor 1	Protein Coding	6.92	DISEASES inferred ¹⁵
14	CNTNAP2	Contactin Associated Protein 2	Protein Coding	6.92	DISEASES inferred ¹⁵
15	PNMA2	PNMA Family Member 2	Protein Coding	6.88	DISEASES inferred ¹⁵
16	CNTN1	Contactin 1	Protein Coding	6.81	DISEASES inferred ¹⁵
17	CD4	CD4 Molecule	Protein Coding	6.78	DISEASES inferred ¹⁵
18	IL17A	Interleukin 17A	Protein Coding	6.77	DISEASES inferred ¹⁵
19	KCNJ10	Potassium Inwardly Rectifying Channel Subfamily J Member 10	Protein Coding	6.73	DISEASES inferred ¹⁵
20	IL6	Interleukin 6	Protein Coding	6.72	DISEASES inferred ¹⁵
21	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	6.7	DISEASES inferred ¹⁵
22	CD19	CD19 Molecule	Protein Coding	6.61	DISEASES inferred ¹⁵
23	ALB	Albumin	Protein Coding	6.55	DISEASES inferred ¹⁵
24	IL10	Interleukin 10	Protein Coding	6.46	DISEASES inferred ¹⁵
25	CNTNAP1	Contactin Associated Protein 1	Protein Coding	6.45	DISEASES inferred ¹⁵
26	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	6.42	DISEASES inferred ¹⁵
27	CD8A	CD8a Molecule	Protein Coding	6.4	DISEASES inferred ¹⁵
28	AGRN	Agrin	Protein Coding	6.4	DISEASES inferred ¹⁵
29	GAD2	Glutamate Decarboxylase 2	Protein Coding	6.34	DISEASES inferred ¹⁵
30	AGFG1	ArfGAP With FG Repeats 1	Protein Coding	6.26	DISEASES inferred ¹⁵
31	RAPSN	Receptor Associated Protein Of The Synapse	Protein Coding	6.25	DISEASES inferred ¹⁵

Sources

Variations for Autoimmune Disease of Peripheral Nervous System

Sources

Expression for Autoimmune Disease of Peripheral Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Peripheral Nervous System.

Sources

Pathways for Autoimmune Disease of Peripheral Nervous System

Pathways related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.59	IL6 IL17A CD4
2	Spinal Cord Injury ¹	11.54	MBP MAG IL6 AQP4
3	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.51	IL17A CD4 CCR6
4	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.46	IL6 IL17A CD4
5	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.41	IL6 IFNB1 CD4
6	Cell adhesion molecules ³⁶	11.27	NFASC MAG ICOSLG CNTNAP2 CNTN1 CD4
7	IgA-Producing B Cells in the Intestine ⁶⁴	11.25	IL6 ICOSLG CCR6
8	Cytokines and Inflammatory Response ¹	10.59	IL6 IFNB1 CD4
9	Glial Cell Differentiation ¹	10.22	MBP MAG

Sources

GO Terms for Autoimmune Disease of Peripheral Nervous System

Cellular components related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.8	NFASC MUSK MAG KCNJ10 CD4 CCR6
2	paranodal junction	GO:0033010	9.16	NFASC CNTNAP2
3	external side of plasma membrane	GO:0009897	9.1	MOG IL17A ICOSLG CD4 CCR6 AQP4
4	compact myelin	GO:0043218	8.96	MBP MAG

Biological processes related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:0007399	9.83	SOX1 MAG LGI1 DPYSL5 CNTN1
2	immune response	GO:0006955	9.72	MBP IL6 IL17A CD4 CCR6
3	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.65	IL6 CNTN1 CD4
4	cell adhesion	GO:0007155	9.63	NFASC MOG MAG CNTNAP2 CNTN1 CD4
5	positive regulation of interleukin-6 production	GO:0032755	9.58	MBP IL6 IL17A
6	defense response to Gram-negative bacterium	GO:0050829	9.54	IL6 IL17A CD4
7	central nervous system myelination	GO:0022010	9.46	MAG KCNJ10
8	humoral immune response	GO:0006959	9.43	IL6 IFNB1 CCR6
9	neuron projection development	GO:0031175	9.26	LGI1 IL6 CNTNAP2 CNTN1
10	transmission of nerve impulse	GO:0019226	8.8	NFASC MAG CNTNAP2

Molecular functions related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.93	SOX1 PNMA2 NFASC MUSK MOG MBP
2	signaling receptor binding	GO:0005102	9.02	MOG MAG LGI1 ICOSLG CD4

Sources

Sources for Autoimmune Disease of Peripheral Nervous System

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia