Autoimmune Disease of Peripheral Nervous System disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Autoimmune Disease of Peripheral Nervous System

MalaCards integrated aliases for Autoimmune Disease of Peripheral Nervous System:

Name: Autoimmune Disease of Peripheral Nervous System ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060033

Sources

Summaries for Autoimmune Disease of Peripheral Nervous System

Disease Ontology : ¹² An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.

MalaCards based summary : Autoimmune Disease of Peripheral Nervous System is related to autoimmune peripheral neuropathy and autoimmune optic neuritis. An important gene associated with Autoimmune Disease of Peripheral Nervous System is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Neuroscience and Cell adhesion molecules (CAMs). Affiliated tissues include t cells and spinal cord, and related phenotypes are behavior/neurological and mortality/aging

Sources

Related Diseases for Autoimmune Disease of Peripheral Nervous System

Diseases in the Peripheral Nervous System Disease family:

Autoimmune Disease of Peripheral Nervous System

Diseases related to Autoimmune Disease of Peripheral Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)

#	Related Disease	Score	Top Affiliating Genes
1	autoimmune peripheral neuropathy	31.8	MAG RPS19
2	autoimmune optic neuritis	31.7	CNTNAP1 MBP MOG
3	guillain-barre syndrome	30.8	ALB GALE HMGA2 MBP PMP2 PMP22
4	congenital hypomyelination neuropathy	10.3	MBP PMP22
5	central pontine myelinolysis	10.3	MAG MBP
6	meningovascular neurosyphilis	10.3	ALB MBP
7	encephalitozoonosis	10.3	PMP2 TNF
8	osteosclerotic myeloma	10.3	MAG TNF
9	burns	10.3	ALB TNF
10	chronic graft versus host disease	10.2	ALB TNF
11	polyneuropathy	10.2	MAG MBP PMP22
12	chronic inflammatory demyelinating polyradiculoneuropathy	10.2	ALB NFASC PMP22
13	pelizaeus-merzbacher disease	10.2	MAG MBP PMP22
14	allergic encephalomyelitis	10.2	MBP MOG
15	jejunoileitis	10.2	ALB TNF
16	balo concentric sclerosis	10.2	MBP MOG
17	tuberculous peritonitis	10.2	ALB TNF
18	miller fisher syndrome	10.2	HMGA2 MAG TNF
19	panencephalitis, subacute sclerosing	10.2	MBP MOG
20	transient arthritis	10.2	ALB MBP
21	hypersensitivity reaction type iii disease	10.2	ALB TNF
22	transverse myelitis	10.2	MBP TNF
23	tabes dorsalis	10.2	DDX41 MBP
24	compartment syndrome	10.1	ALB TNF
25	demyelinating polyneuropathy	10.1	ALB MAG NFASC PMP22
26	internuclear ophthalmoplegia	10.1	MBP MOG
27	pneumocystosis	10.1	ALB TNF
28	autoimmune disease	10.1	MBP MOG TNF
29	myelitis	10.0	MBP MOG TNF
30	primary progressive multiple sclerosis	10.0	MBP MOG TNF
31	primary bacterial infectious disease	10.0	ALB DDX41 TNF
32	relapsing-remitting multiple sclerosis	10.0	MBP MOG TNF
33	central nervous system disease	10.0	MBP MOG TNF
34	autoimmune neuropathy	10.0	CNTNAP1 HMGA2 MAG NFASC
35	acute disseminated encephalomyelitis	10.0	MBP MOG
36	spindle cell synovial sarcoma	9.9	MAG MBP
37	optic neuritis	9.9	MAG MBP MOG TNF
38	autoimmune disease of central nervous system	9.9	MAG MBP MOG TNF
39	multiple sclerosis	9.9	MAG MBP MOG TNF
40	nervous system disease	9.9	ALB MBP MOG TNF
41	spinal cord disease	9.8	DDX41 MBP MOG TNF
42	immune system disease	9.8	DDX41 MBP MOG TNF
43	demyelinating disease	9.8	GALC MAG MBP MOG TNF
44	polyradiculoneuropathy	9.8	ALB MAG MBP NFASC PMP2 PMP22
45	charcot-marie-tooth disease	9.8	CNTNAP1 MAG MBP PMP2 PMP22
46	neuritis	9.6	MAG MBP MOG PMP2 PMP22 TNF
47	peripheral nervous system disease	9.5	ALB MAG MBP MOG NFASC PMP22

Graphical network of the top 20 diseases related to Autoimmune Disease of Peripheral Nervous System:

Sources

Symptoms & Phenotypes for Autoimmune Disease of Peripheral Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Peripheral Nervous System:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.85	CNTNAP1 GALC GLDN MAG MBP MOG
2	mortality/aging	MP:0010768	9.7	ALB CNTNAP1 DDX41 GALC GLDN MBP
3	nervous system	MP:0003631	9.32	CNTNAP1 GALC GLDN MAG MBP MOG

Sources

Drugs & Therapeutics for Autoimmune Disease of Peripheral Nervous System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Peripheral Nervous System

Sources

Genetic Tests for Autoimmune Disease of Peripheral Nervous System

Sources

Anatomical Context for Autoimmune Disease of Peripheral Nervous System

MalaCards organs/tissues related to Autoimmune Disease of Peripheral Nervous System:

⁴²

T Cells, Spinal Cord

Sources

Publications for Autoimmune Disease of Peripheral Nervous System

Sources

Genes for Autoimmune Disease of Peripheral Nervous System

Genes related to Autoimmune Disease of Peripheral Nervous System (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PMP22	Peripheral Myelin Protein 22	Protein Coding	17.56	DISEASES inferred ¹⁵
2	MAG	Myelin Associated Glycoprotein	Protein Coding	17	DISEASES inferred ¹⁵
3	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	16.95	DISEASES inferred ¹⁵
4	GALC	Galactosylceramidase	Protein Coding	16.71	DISEASES inferred ¹⁵
5	NFASC	Neurofascin	Protein Coding	16.64	DISEASES inferred ¹⁵
6	PMP2	Peripheral Myelin Protein 2	Protein Coding	15.99	DISEASES inferred ¹⁵
7	ALB	Albumin	Protein Coding	15.92	DISEASES inferred ¹⁵
8	GLDN	Gliomedin	Protein Coding	15.88	DISEASES inferred ¹⁵
9	MBP	Myelin Basic Protein	Protein Coding	15.68	DISEASES inferred ¹⁵
10	TNF	Tumor Necrosis Factor	Protein Coding	15.66	DISEASES inferred ¹⁵
11	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	15.47	DISEASES inferred ¹⁵
12	DDX41	DEAD-Box Helicase 41	Protein Coding	15.25	DISEASES inferred ¹⁵
13	RPS19	Ribosomal Protein S19	Protein Coding	15.23	DISEASES inferred ¹⁵
14	GALE	UDP-Galactose-4-Epimerase	Protein Coding	15.15	DISEASES inferred ¹⁵
15	SUCLG2	Succinate-CoA Ligase GDP-Forming Beta Subunit	Protein Coding	15.13	DISEASES inferred ¹⁵
16	CNTNAP1	Contactin Associated Protein 1	Protein Coding	15.03	DISEASES inferred ¹⁵

Sources

Variations for Autoimmune Disease of Peripheral Nervous System

Sources

Expression for Autoimmune Disease of Peripheral Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Peripheral Nervous System.

Sources

Pathways for Autoimmune Disease of Peripheral Nervous System

Pathways related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.79	CNTNAP1 MAG MBP NFASC
2	Cell adhesion molecules (CAMs) ³⁸	11.6	CNTNAP1 MAG NFASC
3	Spinal Cord Injury ¹	11.41	MAG MBP TNF
4	Glial Cell Differentiation ¹	9.53	MAG MBP

Sources

GO Terms for Autoimmune Disease of Peripheral Nervous System

Cellular components related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	paranode region of axon	GO:0033270	9.33	CNTNAP1 MAG NFASC
2	paranodal junction	GO:0033010	9.26	CNTNAP1 NFASC
3	compact myelin	GO:0043218	9.13	MAG MBP PMP22
4	myelin sheath	GO:0043209	8.8	MAG MBP PMP2

Biological processes related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peripheral nervous system development	GO:0007422	9.46	NFASC PMP22
2	heterotypic cell-cell adhesion	GO:0034113	9.43	GLDN NFASC
3	transmission of nerve impulse	GO:0019226	9.4	MAG NFASC
4	central nervous system myelination	GO:0022010	9.37	CNTNAP1 MAG
5	clustering of voltage-gated sodium channels	GO:0045162	9.32	GLDN NFASC
6	paranodal junction assembly	GO:0030913	9.26	CNTNAP1 NFASC
7	protein localization to juxtaparanode region of axon	GO:0071205	9.16	CNTNAP1 NFASC
8	protein localization to paranode region of axon	GO:0002175	8.96	CNTNAP1 NFASC
9	myelination	GO:0042552	8.8	MBP NFASC PMP22

Molecular functions related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	fatty acid binding	GO:0005504	8.96	ALB PMP2
2	protein binding involved in heterotypic cell-cell adhesion	GO:0086080	8.62	GLDN NFASC

Sources

Sources for Autoimmune Disease of Peripheral Nervous System

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia