MCID: ATM105
MIFTS: 25

Autoimmune Disease of Peripheral Nervous System

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Autoimmune Disease of Peripheral Nervous System

MalaCards integrated aliases for Autoimmune Disease of Peripheral Nervous System:

Name: Autoimmune Disease of Peripheral Nervous System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060033

Summaries for Autoimmune Disease of Peripheral Nervous System

Disease Ontology : 12 An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.

MalaCards based summary : Autoimmune Disease of Peripheral Nervous System is related to autoimmune peripheral neuropathy and autoimmune optic neuritis. An important gene associated with Autoimmune Disease of Peripheral Nervous System is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Neuroscience and Cell adhesion molecules (CAMs). Affiliated tissues include t cells and spinal cord, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Autoimmune Disease of Peripheral Nervous System

Diseases in the Peripheral Nervous System Disease family:

Autoimmune Disease of Peripheral Nervous System

Diseases related to Autoimmune Disease of Peripheral Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 autoimmune peripheral neuropathy 31.8 MAG RPS19
2 autoimmune optic neuritis 31.7 CNTNAP1 MBP MOG
3 guillain-barre syndrome 30.8 ALB GALE HMGA2 MBP PMP2 PMP22
4 congenital hypomyelination neuropathy 10.3 MBP PMP22
5 central pontine myelinolysis 10.3 MAG MBP
6 meningovascular neurosyphilis 10.3 ALB MBP
7 encephalitozoonosis 10.3 PMP2 TNF
8 osteosclerotic myeloma 10.3 MAG TNF
9 burns 10.3 ALB TNF
10 chronic graft versus host disease 10.2 ALB TNF
11 polyneuropathy 10.2 MAG MBP PMP22
12 chronic inflammatory demyelinating polyradiculoneuropathy 10.2 ALB NFASC PMP22
13 pelizaeus-merzbacher disease 10.2 MAG MBP PMP22
14 allergic encephalomyelitis 10.2 MBP MOG
15 jejunoileitis 10.2 ALB TNF
16 balo concentric sclerosis 10.2 MBP MOG
17 tuberculous peritonitis 10.2 ALB TNF
18 miller fisher syndrome 10.2 HMGA2 MAG TNF
19 panencephalitis, subacute sclerosing 10.2 MBP MOG
20 transient arthritis 10.2 ALB MBP
21 hypersensitivity reaction type iii disease 10.2 ALB TNF
22 transverse myelitis 10.2 MBP TNF
23 tabes dorsalis 10.2 DDX41 MBP
24 compartment syndrome 10.1 ALB TNF
25 demyelinating polyneuropathy 10.1 ALB MAG NFASC PMP22
26 internuclear ophthalmoplegia 10.1 MBP MOG
27 pneumocystosis 10.1 ALB TNF
28 autoimmune disease 10.1 MBP MOG TNF
29 myelitis 10.0 MBP MOG TNF
30 primary progressive multiple sclerosis 10.0 MBP MOG TNF
31 primary bacterial infectious disease 10.0 ALB DDX41 TNF
32 relapsing-remitting multiple sclerosis 10.0 MBP MOG TNF
33 central nervous system disease 10.0 MBP MOG TNF
34 autoimmune neuropathy 10.0 CNTNAP1 HMGA2 MAG NFASC
35 acute disseminated encephalomyelitis 10.0 MBP MOG
36 spindle cell synovial sarcoma 9.9 MAG MBP
37 optic neuritis 9.9 MAG MBP MOG TNF
38 autoimmune disease of central nervous system 9.9 MAG MBP MOG TNF
39 multiple sclerosis 9.9 MAG MBP MOG TNF
40 nervous system disease 9.9 ALB MBP MOG TNF
41 spinal cord disease 9.8 DDX41 MBP MOG TNF
42 immune system disease 9.8 DDX41 MBP MOG TNF
43 demyelinating disease 9.8 GALC MAG MBP MOG TNF
44 polyradiculoneuropathy 9.8 ALB MAG MBP NFASC PMP2 PMP22
45 charcot-marie-tooth disease 9.8 CNTNAP1 MAG MBP PMP2 PMP22
46 neuritis 9.6 MAG MBP MOG PMP2 PMP22 TNF
47 peripheral nervous system disease 9.5 ALB MAG MBP MOG NFASC PMP22

Graphical network of the top 20 diseases related to Autoimmune Disease of Peripheral Nervous System:



Diseases related to Autoimmune Disease of Peripheral Nervous System

Symptoms & Phenotypes for Autoimmune Disease of Peripheral Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Peripheral Nervous System:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 CNTNAP1 GALC GLDN MAG MBP MOG
2 mortality/aging MP:0010768 9.7 ALB CNTNAP1 DDX41 GALC GLDN MBP
3 nervous system MP:0003631 9.32 CNTNAP1 GALC GLDN MAG MBP MOG

Drugs & Therapeutics for Autoimmune Disease of Peripheral Nervous System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Peripheral Nervous System

Genetic Tests for Autoimmune Disease of Peripheral Nervous System

Anatomical Context for Autoimmune Disease of Peripheral Nervous System

MalaCards organs/tissues related to Autoimmune Disease of Peripheral Nervous System:

42
T Cells, Spinal Cord

Publications for Autoimmune Disease of Peripheral Nervous System

Variations for Autoimmune Disease of Peripheral Nervous System

Expression for Autoimmune Disease of Peripheral Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Peripheral Nervous System.

Pathways for Autoimmune Disease of Peripheral Nervous System

Pathways related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 CNTNAP1 MAG MBP NFASC
2 11.6 CNTNAP1 MAG NFASC
3 11.41 MAG MBP TNF
4 9.53 MAG MBP

GO Terms for Autoimmune Disease of Peripheral Nervous System

Cellular components related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 paranode region of axon GO:0033270 9.33 CNTNAP1 MAG NFASC
2 paranodal junction GO:0033010 9.26 CNTNAP1 NFASC
3 compact myelin GO:0043218 9.13 MAG MBP PMP22
4 myelin sheath GO:0043209 8.8 MAG MBP PMP2

Biological processes related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.46 NFASC PMP22
2 heterotypic cell-cell adhesion GO:0034113 9.43 GLDN NFASC
3 transmission of nerve impulse GO:0019226 9.4 MAG NFASC
4 central nervous system myelination GO:0022010 9.37 CNTNAP1 MAG
5 clustering of voltage-gated sodium channels GO:0045162 9.32 GLDN NFASC
6 paranodal junction assembly GO:0030913 9.26 CNTNAP1 NFASC
7 protein localization to juxtaparanode region of axon GO:0071205 9.16 CNTNAP1 NFASC
8 protein localization to paranode region of axon GO:0002175 8.96 CNTNAP1 NFASC
9 myelination GO:0042552 8.8 MBP NFASC PMP22

Molecular functions related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 8.96 ALB PMP2
2 protein binding involved in heterotypic cell-cell adhesion GO:0086080 8.62 GLDN NFASC

Sources for Autoimmune Disease of Peripheral Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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