Autoimmune Disease of Peripheral Nervous System disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Autoimmune Disease of Peripheral Nervous System

MalaCards integrated aliases for Autoimmune Disease of Peripheral Nervous System:

Name: Autoimmune Disease of Peripheral Nervous System ¹¹ ¹⁴

Classifications:

MalaCards categories:
Anatomical: Immune diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060033

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Summaries for Autoimmune Disease of Peripheral Nervous System

Disease Ontology: ¹¹ An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.

MalaCards based summary: Autoimmune Disease of Peripheral Nervous System is related to guillain-barre syndrome and autoimmune optic neuritis. An important gene associated with Autoimmune Disease of Peripheral Nervous System is AQP4 (Aquaporin 4), and among its related pathways/superpathways are IL27-mediated signaling events and Th17 Differentiation. Affiliated tissues include t cells, and related phenotypes are nervous system and growth/size/body region

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Related Diseases for Autoimmune Disease of Peripheral Nervous System

Diseases in the Peripheral Nervous System Disease family:

Autoimmune Disease of Peripheral Nervous System

Diseases related to Autoimmune Disease of Peripheral Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 424)

#	Related Disease	Score	Top Affiliating Genes
1	guillain-barre syndrome	32.4	MOG MBP IL17A
2	autoimmune optic neuritis	32.4	MOG MBP MAG DPYSL5 AQP4
3	autoimmune peripheral neuropathy	32.3	NFASC MAG ICOSLG CNTN1 CD4
4	chronic inflammatory demyelinating polyradiculoneuropathy	32.1	NFASC MUSK MBP MAG IFNB1 ICOSLG
5	intermittent proptosis	10.5	MOG AQP4
6	tuberculous encephalopathy	10.5	MOG AQP4
7	sarcoid meningitis	10.4	MOG MBP AQP4
8	acute hemorrhagic leukoencephalitis	10.4	MOG MBP AQP4
9	abducens palsy	10.4	MUSK MOG AQP4
10	central pontine myelinolysis	10.4	MBP MAG AQP4
11	supratentorial meningioma	10.4	LGI1 AQP4
12	arachnoiditis	10.4	MBP CD4 AQP4
13	mikulicz disease	10.4	ICOSLG CD4 CCR6
14	cranial nerve palsy	10.4	MOG CD4 AQP4
15	acute retrobulbar neuritis	10.4	MOG MBP IFNB1 AQP4
16	cerebellopontine angle meningioma	10.4	DPYSL5 AMPH
17	inappropriate adh syndrome	10.4	LGI1 IL6 AQP4
18	castleman disease	10.4	IL6 CD4 CCR6
19	pollen allergy	10.4	ICOSLG CD4 CCR6
20	xerophthalmia	10.4	ICOSLG CD4 CCR6
21	immunodeficiency 14	10.4	ICOSLG CD4 CCR6
22	immunodeficiency 16	10.4	ICOSLG CD4 CCR6
23	pharyngitis	10.4	IL6 CD4 CCR6
24	legume allergy	10.4	ICOSLG CD4 CCR6
25	fruit allergy	10.4	ICOSLG CD4 CCR6
26	osteosclerotic myeloma	10.4	MAG IL6
27	syphilis	10.4	IL17A CD4 CCR6
28	peanut allergy	10.4	ICOSLG CD4 CCR6
29	dysgammaglobulinemia	10.4	MBP ICOSLG CD4
30	childhood type dermatomyositis	10.4	ICOSLG CD4 CCR6
31	cerebritis	10.4	IL6 CD4 AQP4
32	akinetic mutism	10.4	PNMA2 MBP LGI1
33	autoimmune pancreatitis	10.4	ICOSLG CD4 CCR6
34	retinal vasculitis	10.4	IFNB1 CD4 CCR6
35	subacute sclerosing panencephalitis	10.4	MOG MBP IL6
36	genital herpes	10.4	IFNB1 CD4 CCR6
37	keratoconjunctivitis sicca	10.4	ICOSLG CD4 CCR6
38	sialadenitis	10.4	ICOSLG CD4 CCR6
39	vascular myelopathy	10.4	MOG DPYSL5 AQP4 AMPH
40	stomatitis	10.4	IL6 IFNB1 CD4
41	pernicious anemia	10.4	ICOSLG CD4 CCR6
42	congenital hypogammaglobulinemia	10.4	CD4 CD19
43	angioimmunoblastic t-cell lymphoma	10.4	ICOSLG CD4 CCR6
44	mononeuritis of upper limb and mononeuritis multiplex	10.4	MAG DPYSL5 CD4
45	mononeuritis multiplex	10.4	MAG DPYSL5 CD4
46	auditory agnosia	10.4	LGI1 CNTNAP2
47	non-severe covid-19	10.4	IL6 CD4 CCR6
48	agammaglobulinemia, x-linked	10.4	ICOSLG CD19 CCR6
49	bell's palsy	10.4	MBP IL6 CD4
50	interstitial nephritis	10.4	ICOSLG CD4 CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of Peripheral Nervous System:

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Symptoms & Phenotypes for Autoimmune Disease of Peripheral Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Peripheral Nervous System:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.25	AMPH AQP4 CCR6 CD19 CD4 CNTN1
2	growth/size/body region	MP:0005378	10.07	AQP4 CD19 CD4 CNTN1 CNTNAP2 IL17A
3	behavior/neurological	MP:0005386	10.03	AMPH AQP4 CD19 CNTN1 CNTNAP2 DPYSL5
4	immune system	MP:0005387	9.73	AQP4 CCR6 CD19 CD4 ICOSLG IFNB1
5	hematopoietic system	MP:0005397	9.4	AQP4 CCR6 CD19 CD4 ICOSLG IFNB1

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Drugs & Therapeutics for Autoimmune Disease of Peripheral Nervous System

Search Clinical Trials, NIH Clinical Center for Autoimmune Disease of Peripheral Nervous System

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Genetic Tests for Autoimmune Disease of Peripheral Nervous System

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Anatomical Context for Autoimmune Disease of Peripheral Nervous System

Organs/tissues related to Autoimmune Disease of Peripheral Nervous System:

MalaCards : T Cells

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Publications for Autoimmune Disease of Peripheral Nervous System

Articles related to Autoimmune Disease of Peripheral Nervous System:

#	Title	Authors	PMID	Year
1	Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system. ⁶²	Abbas N...Zhu J	11078155	2000

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Genes for Autoimmune Disease of Peripheral Nervous System

Genes related to Autoimmune Disease of Peripheral Nervous System (0 elite genes):

(show all 36)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AQP4	Aquaporin 4	Protein Coding	10.56	DISEASES inferred ¹⁴
2	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	9.54	DISEASES inferred ¹⁴
3	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.22	DISEASES inferred ¹⁴ ¹⁴
4	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	8.88	DISEASES inferred ¹⁴ ¹⁴
5	MBP	Myelin Basic Protein	Protein Coding	7.52	DISEASES inferred ¹⁴
6	NFASC	Neurofascin	Protein Coding	7.5	DISEASES inferred ¹⁴
7	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	7.5	DISEASES inferred ¹⁴
8	IFNB1	Interferon Beta 1	Protein Coding	7.38	DISEASES inferred ¹⁴
9	MAG	Myelin Associated Glycoprotein	Protein Coding	7.33	DISEASES inferred ¹⁴
10	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	7.28	DISEASES inferred ¹⁴
11	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	7.19	DISEASES inferred ¹⁴
12	CNTNAP2	Contactin Associated Protein 2	Protein Coding	7.06	DISEASES inferred ¹⁴
13	AMPH	Amphiphysin	Protein Coding	7.04	DISEASES inferred ¹⁴
14	IL6	Interleukin 6	Protein Coding	6.94	DISEASES inferred ¹⁴
15	CNTN1	Contactin 1	Protein Coding	6.93	DISEASES inferred ¹⁴
16	SOX1	SRY-Box Transcription Factor 1	Protein Coding	6.9	DISEASES inferred ¹⁴
17	CD19	CD19 Molecule	Protein Coding	6.86	DISEASES inferred ¹⁴
18	CD4	CD4 Molecule	Protein Coding	6.82	DISEASES inferred ¹⁴
19	PNMA2	PNMA Family Member 2	Protein Coding	6.77	DISEASES inferred ¹⁴
20	IL17A	Interleukin 17A	Protein Coding	6.68	DISEASES inferred ¹⁴
21	ALB	Albumin	Protein Coding	6.54	DISEASES inferred ¹⁴
22	IL10	Interleukin 10	Protein Coding	6.53	DISEASES inferred ¹⁴
23	CD8A	CD8a Molecule	Protein Coding	6.51	DISEASES inferred ¹⁴
24	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	6.49	DISEASES inferred ¹⁴
25	NEFL	Neurofilament Light Chain	Protein Coding	6.49	DISEASES inferred ¹⁴
26	CNTNAP1	Contactin Associated Protein 1	Protein Coding	6.47	DISEASES inferred ¹⁴
27	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	6.44	DISEASES inferred ¹⁴
28	GAD2	Glutamate Decarboxylase 2	Protein Coding	6.42	DISEASES inferred ¹⁴
29	TNF	Tumor Necrosis Factor	Protein Coding	6.38	DISEASES inferred ¹⁴
30	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	6.33	DISEASES inferred ¹⁴
31	AGRN	Agrin	Protein Coding	6.32	DISEASES inferred ¹⁴
32	KCNJ10	Potassium Inwardly Rectifying Channel Subfamily J Member 10	Protein Coding	6.32	DISEASES inferred ¹⁴
33	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	6.31	DISEASES inferred ¹⁴
34	IGLON5	IgLON Family Member 5	Protein Coding	6.26	DISEASES inferred ¹⁴
35	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	6.26	DISEASES inferred ¹⁴
36	AGFG1	ArfGAP With FG Repeats 1	Protein Coding	6.25	DISEASES inferred ¹⁴

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Variations for Autoimmune Disease of Peripheral Nervous System

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Expression for Autoimmune Disease of Peripheral Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Peripheral Nervous System.

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Pathways for Autoimmune Disease of Peripheral Nervous System

Pathways related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.65	IL6 IL17A CD4
2	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.59	IL6 IL17A CD4
3	Spinal cord injury ⁷⁴	11.52	MBP MAG IL6 AQP4
4	Innate Lymphoid Cells Differentiation ⁶⁵	11.51	IL17A CD4 CCR6
5	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.47	IL6 IFNB1 CD4
6	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.4	IL6 ICOSLG CD19
7	Th17 cell differentiation pathway ⁷⁴	11.34	IL6 IL17A CD4
8	Dendritic Cells Developmental Lineage Pathway ⁶⁵	10.79	IL6 IFNB1 CD4 CD19
9	Cytokines and inflammatory response ⁷⁴	10.59	IL6 IFNB1 CD4
10	Glial cell differentiation ⁷⁴	10.16	MBP MAG

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GO Terms for Autoimmune Disease of Peripheral Nervous System

Cellular components related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.18	NFASC MUSK MAG CD4 CD19 CCR6
2	plasma membrane	GO:0005887	10.18	NFASC MUSK MAG CD4 CD19 CCR6
3	external side of plasma membrane	GO:0009897	9.47	MOG IL17A ICOSLG CD4 CD19 CCR6
4	compact myelin	GO:0043218	9.26	MBP MAG

Biological processes related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neuron projection development	GO:0031175	9.8	LGI1 IL6 CNTNAP2 CNTN1
2	central nervous system myelin formation	GO:0032289	9.62	MAG CNTN1
3	regulation of vascular endothelial growth factor production	GO:0010574	9.46	IL6 AQP4
4	transmission of nerve impulse	GO:0019226	9.43	NFASC MAG CNTNAP2
5	myelination	GO:0042552	9.1	NFASC MBP MAG CNTN1

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Sources for Autoimmune Disease of Peripheral Nervous System

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ATM105 MIFTS: 25	Autoimmune Disease of Peripheral Nervous System Categories: Immune diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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