MCID: ATM105
MIFTS: 27

Autoimmune Disease of Peripheral Nervous System

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Autoimmune Disease of Peripheral Nervous System

MalaCards integrated aliases for Autoimmune Disease of Peripheral Nervous System:

Name: Autoimmune Disease of Peripheral Nervous System 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060033

Summaries for Autoimmune Disease of Peripheral Nervous System

Disease Ontology : 12 An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.

MalaCards based summary : Autoimmune Disease of Peripheral Nervous System is related to autoimmune peripheral neuropathy and guillain-barre syndrome. An important gene associated with Autoimmune Disease of Peripheral Nervous System is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Th17 Differentiation Pathway and Spinal Cord Injury. Affiliated tissues include t cells, skin and bone, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Autoimmune Disease of Peripheral Nervous System

Diseases in the Peripheral Nervous System Disease family:

Autoimmune Disease of Peripheral Nervous System

Diseases related to Autoimmune Disease of Peripheral Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 autoimmune peripheral neuropathy 32.4 MAG ICOSLG CD4
2 guillain-barre syndrome 32.4 MOG MBP IL17A
3 chronic inflammatory demyelinating polyradiculoneuropathy 32.3 MBP IL17A IFNB1 ICOSLG
4 autoimmune optic neuritis 32.2 MOG MBP KCNJ10 DPYSL5 AQP4
5 allergic encephalomyelitis 10.5 MOG MBP
6 paraneoplastic polyneuropathy 10.4 MAG AMPH
7 acute retrobulbar neuritis 10.4 MBP AQP4
8 central pontine myelinolysis 10.4 MBP MAG AQP4
9 abducens nerve disease 10.4 MUSK AQP4
10 partial optic atrophy 10.4 DPYSL5 AMPH
11 chorea gravidarum 10.4 DPYSL5 CNTNAP2
12 color agnosia 10.4 MBP CNTNAP2 AQP4
13 optic papillitis 10.4 MOG CD4 AQP4
14 post-vaccinal encephalitis 10.4 MBP ICOSLG
15 acute transverse myelitis 10.4 IL6 AQP4
16 herpes simplex virus keratitis 10.4 IFNB1 CD4 CCR6
17 cerebellopontine angle tumor 10.4 DPYSL5 CNTNAP2
18 legume allergy 10.4 ICOSLG CD4 CCR6
19 fruit allergy 10.4 ICOSLG CD4 CCR6
20 autoimmune encephalitis 10.4 LGI1 CNTNAP2
21 immunodeficiency 16 10.4 ICOSLG CD4 CCR6
22 autoimmune glomerulonephritis 10.4 ICOSLG CD4 CCR6
23 balo concentric sclerosis 10.4 MOG MBP IFNB1 AQP4
24 postinfectious encephalitis 10.4 MBP LGI1 CNTNAP2
25 primary thrombocytopenia 10.4 ICOSLG CD4 CCR6
26 retinal vasculitis 10.4 IFNB1 CD4 CCR6
27 suppurative lymphadenitis 10.4 CD4 CCR6
28 sialadenitis 10.4 ICOSLG CD4 CCR6
29 anogenital venereal wart 10.4 IFNB1 CD4 CCR6
30 osteosclerotic myeloma 10.4 MAG IL6
31 immunoglobulin alpha deficiency 10.4 ICOSLG CD4 CCR6
32 anemia, autoimmune hemolytic 10.4 ICOSLG CD4 CCR6
33 nasopharyngitis 10.4 IL17A IFNB1 CCR6
34 dissociative amnesia 10.4 LGI1 CNTNAP2
35 respiratory allergy 10.4 ICOSLG CD4 CCR6
36 traumatic brain injury 10.4 MBP IL6 AQP4
37 brain injury 10.4 MBP IL6 AQP4
38 bullous skin disease 10.4 ICOSLG CD4 CCR6
39 primary progressive multiple sclerosis 10.4 MOG MBP IFNB1
40 immunodeficiency with hyper-igm, type 1 10.4 ICOSLG CD4 CCR6
41 vascular myelopathy 10.4 MOG DPYSL5 AQP4 AMPH
42 arachnoiditis 10.4 CD4 AQP4
43 thrombocytopenic purpura, autoimmune 10.4 ICOSLG CD4 CCR6
44 anal spasm 10.3 DPYSL5 CD4 AMPH
45 lambert-eaton myasthenic syndrome 10.3 SOX1 MUSK AMPH
46 agammaglobulinemia, x-linked 10.3 ICOSLG CD4 CCR6
47 herpes zoster 10.3 ICOSLG CD4 CCR6
48 neuroretinitis 10.3 DPYSL5 CD4
49 esophageal candidiasis 10.3 IL17A CD4 CCR6
50 subcutaneous mycosis 10.3 IL17A CD4 CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of Peripheral Nervous System:



Diseases related to Autoimmune Disease of Peripheral Nervous System

Symptoms & Phenotypes for Autoimmune Disease of Peripheral Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Peripheral Nervous System:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 AMPH AQP4 CNTN1 CNTNAP2 DPYSL5 IL6
2 growth/size/body region MP:0005378 9.8 AQP4 CD4 CNTN1 CNTNAP2 IL17A IL6
3 nervous system MP:0003631 9.55 AMPH AQP4 CCR6 CD4 CNTN1 CNTNAP2

Drugs & Therapeutics for Autoimmune Disease of Peripheral Nervous System

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Peripheral Nervous System

Genetic Tests for Autoimmune Disease of Peripheral Nervous System

Anatomical Context for Autoimmune Disease of Peripheral Nervous System

MalaCards organs/tissues related to Autoimmune Disease of Peripheral Nervous System:

40
T Cells, Skin, Bone, Thymus, Brain, Bone Marrow, Eye

Publications for Autoimmune Disease of Peripheral Nervous System

Articles related to Autoimmune Disease of Peripheral Nervous System:

# Title Authors PMID Year
1
Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system. 61
11078155 2000

Variations for Autoimmune Disease of Peripheral Nervous System

Expression for Autoimmune Disease of Peripheral Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Peripheral Nervous System.

Pathways for Autoimmune Disease of Peripheral Nervous System

GO Terms for Autoimmune Disease of Peripheral Nervous System

Cellular components related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 NFASC MUSK MAG KCNJ10 CD4 CCR6
2 paranodal junction GO:0033010 9.16 NFASC CNTNAP2
3 external side of plasma membrane GO:0009897 9.1 MOG IL17A ICOSLG CD4 CCR6 AQP4
4 compact myelin GO:0043218 8.96 MBP MAG

Biological processes related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.83 SOX1 MAG LGI1 DPYSL5 CNTN1
2 immune response GO:0006955 9.72 MBP IL6 IL17A CD4 CCR6
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.65 IL6 CNTN1 CD4
4 cell adhesion GO:0007155 9.63 NFASC MOG MAG CNTNAP2 CNTN1 CD4
5 positive regulation of interleukin-6 production GO:0032755 9.58 MBP IL6 IL17A
6 defense response to Gram-negative bacterium GO:0050829 9.54 IL6 IL17A CD4
7 central nervous system myelination GO:0022010 9.46 MAG KCNJ10
8 humoral immune response GO:0006959 9.43 IL6 IFNB1 CCR6
9 neuron projection development GO:0031175 9.26 LGI1 IL6 CNTNAP2 CNTN1
10 transmission of nerve impulse GO:0019226 8.8 NFASC MAG CNTNAP2

Molecular functions related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 SOX1 PNMA2 NFASC MUSK MOG MBP
2 signaling receptor binding GO:0005102 9.02 MOG MAG LGI1 ICOSLG CD4

Sources for Autoimmune Disease of Peripheral Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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