MCID: ATM105
MIFTS: 25

Autoimmune Disease of Peripheral Nervous System

Categories: Immune diseases, Neuronal diseases
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Aliases & Classifications for Autoimmune Disease of Peripheral Nervous System

MalaCards integrated aliases for Autoimmune Disease of Peripheral Nervous System:

Name: Autoimmune Disease of Peripheral Nervous System 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060033

Summaries for Autoimmune Disease of Peripheral Nervous System

Disease Ontology: 11 An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.

MalaCards based summary: Autoimmune Disease of Peripheral Nervous System is related to guillain-barre syndrome and autoimmune optic neuritis. An important gene associated with Autoimmune Disease of Peripheral Nervous System is AQP4 (Aquaporin 4), and among its related pathways/superpathways are IL27-mediated signaling events and Th17 Differentiation. Affiliated tissues include t cells, and related phenotypes are nervous system and growth/size/body region

Related Diseases for Autoimmune Disease of Peripheral Nervous System

Diseases in the Peripheral Nervous System Disease family:

Autoimmune Disease of Peripheral Nervous System

Diseases related to Autoimmune Disease of Peripheral Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 424)
# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 32.4 MOG MBP IL17A
2 autoimmune optic neuritis 32.4 MOG MBP MAG DPYSL5 AQP4
3 autoimmune peripheral neuropathy 32.3 NFASC MAG ICOSLG CNTN1 CD4
4 chronic inflammatory demyelinating polyradiculoneuropathy 32.1 NFASC MUSK MBP MAG IFNB1 ICOSLG
5 intermittent proptosis 10.5 MOG AQP4
6 tuberculous encephalopathy 10.5 MOG AQP4
7 sarcoid meningitis 10.4 MOG MBP AQP4
8 acute hemorrhagic leukoencephalitis 10.4 MOG MBP AQP4
9 abducens palsy 10.4 MUSK MOG AQP4
10 central pontine myelinolysis 10.4 MBP MAG AQP4
11 supratentorial meningioma 10.4 LGI1 AQP4
12 arachnoiditis 10.4 MBP CD4 AQP4
13 mikulicz disease 10.4 ICOSLG CD4 CCR6
14 cranial nerve palsy 10.4 MOG CD4 AQP4
15 acute retrobulbar neuritis 10.4 MOG MBP IFNB1 AQP4
16 cerebellopontine angle meningioma 10.4 DPYSL5 AMPH
17 inappropriate adh syndrome 10.4 LGI1 IL6 AQP4
18 castleman disease 10.4 IL6 CD4 CCR6
19 pollen allergy 10.4 ICOSLG CD4 CCR6
20 xerophthalmia 10.4 ICOSLG CD4 CCR6
21 immunodeficiency 14 10.4 ICOSLG CD4 CCR6
22 immunodeficiency 16 10.4 ICOSLG CD4 CCR6
23 pharyngitis 10.4 IL6 CD4 CCR6
24 legume allergy 10.4 ICOSLG CD4 CCR6
25 fruit allergy 10.4 ICOSLG CD4 CCR6
26 osteosclerotic myeloma 10.4 MAG IL6
27 syphilis 10.4 IL17A CD4 CCR6
28 peanut allergy 10.4 ICOSLG CD4 CCR6
29 dysgammaglobulinemia 10.4 MBP ICOSLG CD4
30 childhood type dermatomyositis 10.4 ICOSLG CD4 CCR6
31 cerebritis 10.4 IL6 CD4 AQP4
32 akinetic mutism 10.4 PNMA2 MBP LGI1
33 autoimmune pancreatitis 10.4 ICOSLG CD4 CCR6
34 retinal vasculitis 10.4 IFNB1 CD4 CCR6
35 subacute sclerosing panencephalitis 10.4 MOG MBP IL6
36 genital herpes 10.4 IFNB1 CD4 CCR6
37 keratoconjunctivitis sicca 10.4 ICOSLG CD4 CCR6
38 sialadenitis 10.4 ICOSLG CD4 CCR6
39 vascular myelopathy 10.4 MOG DPYSL5 AQP4 AMPH
40 stomatitis 10.4 IL6 IFNB1 CD4
41 pernicious anemia 10.4 ICOSLG CD4 CCR6
42 congenital hypogammaglobulinemia 10.4 CD4 CD19
43 angioimmunoblastic t-cell lymphoma 10.4 ICOSLG CD4 CCR6
44 mononeuritis of upper limb and mononeuritis multiplex 10.4 MAG DPYSL5 CD4
45 mononeuritis multiplex 10.4 MAG DPYSL5 CD4
46 auditory agnosia 10.4 LGI1 CNTNAP2
47 non-severe covid-19 10.4 IL6 CD4 CCR6
48 agammaglobulinemia, x-linked 10.4 ICOSLG CD19 CCR6
49 bell's palsy 10.4 MBP IL6 CD4
50 interstitial nephritis 10.4 ICOSLG CD4 CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of Peripheral Nervous System:



Diseases related to Autoimmune Disease of Peripheral Nervous System

Symptoms & Phenotypes for Autoimmune Disease of Peripheral Nervous System

MGI Mouse Phenotypes related to Autoimmune Disease of Peripheral Nervous System:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.25 AMPH AQP4 CCR6 CD19 CD4 CNTN1
2 growth/size/body region MP:0005378 10.07 AQP4 CD19 CD4 CNTN1 CNTNAP2 IL17A
3 behavior/neurological MP:0005386 10.03 AMPH AQP4 CD19 CNTN1 CNTNAP2 DPYSL5
4 immune system MP:0005387 9.73 AQP4 CCR6 CD19 CD4 ICOSLG IFNB1
5 hematopoietic system MP:0005397 9.4 AQP4 CCR6 CD19 CD4 ICOSLG IFNB1

Drugs & Therapeutics for Autoimmune Disease of Peripheral Nervous System

Search Clinical Trials, NIH Clinical Center for Autoimmune Disease of Peripheral Nervous System

Genetic Tests for Autoimmune Disease of Peripheral Nervous System

Anatomical Context for Autoimmune Disease of Peripheral Nervous System

Organs/tissues related to Autoimmune Disease of Peripheral Nervous System:

MalaCards : T Cells

Publications for Autoimmune Disease of Peripheral Nervous System

Articles related to Autoimmune Disease of Peripheral Nervous System:

# Title Authors PMID Year
1
Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system. 62
11078155 2000

Variations for Autoimmune Disease of Peripheral Nervous System

Expression for Autoimmune Disease of Peripheral Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Peripheral Nervous System.

Pathways for Autoimmune Disease of Peripheral Nervous System

GO Terms for Autoimmune Disease of Peripheral Nervous System

Cellular components related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.18 NFASC MUSK MAG CD4 CD19 CCR6
2 plasma membrane GO:0005887 10.18 NFASC MUSK MAG CD4 CD19 CCR6
3 external side of plasma membrane GO:0009897 9.47 MOG IL17A ICOSLG CD4 CD19 CCR6
4 compact myelin GO:0043218 9.26 MBP MAG

Biological processes related to Autoimmune Disease of Peripheral Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection development GO:0031175 9.8 LGI1 IL6 CNTNAP2 CNTN1
2 central nervous system myelin formation GO:0032289 9.62 MAG CNTN1
3 regulation of vascular endothelial growth factor production GO:0010574 9.46 IL6 AQP4
4 transmission of nerve impulse GO:0019226 9.43 NFASC MAG CNTNAP2
5 myelination GO:0042552 9.1 NFASC MBP MAG CNTN1

Sources for Autoimmune Disease of Peripheral Nervous System

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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