MCID: ATM016
MIFTS: 31

Autoimmune Disease of Skin and Connective Tissue

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Autoimmune Disease of Skin and Connective Tissue

MalaCards integrated aliases for Autoimmune Disease of Skin and Connective Tissue:

Name: Autoimmune Disease of Skin and Connective Tissue 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060039

Summaries for Autoimmune Disease of Skin and Connective Tissue

Disease Ontology : 12 An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue.

MalaCards based summary : Autoimmune Disease of Skin and Connective Tissue is related to pemphigoid and pemphigus. An important gene associated with Autoimmune Disease of Skin and Connective Tissue is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin and t cells, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Autoimmune Disease of Skin and Connective Tissue

Diseases related to Autoimmune Disease of Skin and Connective Tissue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 806)
# Related Disease Score Top Affiliating Genes
1 pemphigoid 32.6 TNF IL1B DST COL17A1
2 pemphigus 32.3 TNF IL6 IL10 DST DSG3 DSG1
3 neurosyphilis 10.6 IL17A IL10
4 coccidioidomycosis 10.6 IL17A CD4 CCR6
5 external pathological resorption 10.6 TNF IL6
6 lichen planus pemphigoides 10.6 DST COL17A1
7 cork-handlers' disease 10.6 CD8A CD4
8 necrotic uveal melanoma 10.6 CD8A CD4
9 scorpion envenomation 10.6 TNF IL6
10 adult acute lymphocytic leukemia 10.6 CD8A CD4 CCR6
11 drug reaction with eosinophilia and systemic symptoms 10.6 TNF CRP
12 punctate inner choroidopathy 10.5 TNF IL10
13 type 1 diabetes mellitus 23 10.5 TNF CD8A CD4
14 tropical endomyocardial fibrosis 10.5 TNF IL10
15 suppurative lymphadenitis 10.5 CRP CD4 CCR6
16 norwegian scabies 10.5 IL17A CD8A CD4
17 toxic megacolon 10.5 TNF CRP CCR6
18 early yaws 10.5 CD8A CD4
19 rheumatoid arthritis interstitial lung disease 10.5 TNF CRP CD4
20 opportunistic bacterial infectious disease 10.5 TNF CRP CD4
21 granulomatous dermatitis 10.5 TNF CD8A CD4
22 nocardiosis 10.5 TNF CRP CD4
23 enthesopathy 10.5 TNF CRP CCR6
24 dermatophytosis 10.5 IL17A CD4 CCR6
25 primary syphilis 10.5 CRP CD8A CD4
26 gastrointestinal tuberculosis 10.5 TNF CRP CD4
27 intestinal tuberculosis 10.5 TNF CRP CD4
28 uveoparotid fever 10.5 TNF CD8A CD4
29 toxicodendron dermatitis 10.5 TNF IL2 CD8A
30 fasciitis 10.5 TNF IL6 IL2
31 mononeuritis of upper limb and mononeuritis multiplex 10.5 TNF CRP CD4
32 mononeuritis multiplex 10.5 TNF CRP CD4
33 lymph node tuberculosis 10.5 TNF CRP CD4
34 systemic autoimmune disease 10.5 IL6 IL17A CRP
35 immunodeficiency with hyper-igm, type 3 10.5 ICOSLG CD8A CD4
36 retinal vasculitis 10.5 TNF CD4 CCR6
37 abdominal tuberculosis 10.5 TNF CRP CD4
38 physiological polycythemia 10.5 TNF IL6 IL1B
39 secondary syphilis 10.5 CRP CD8A CD4
40 streptococcal toxic-shock syndrome 10.5 TNF IL6 IL2
41 parotid disease 10.5 CRP CD8A CD4
42 igg4-related disease 10.5 ICOSLG CRP CCR6
43 mucormycosis 10.5 CRP CD4 CCR6
44 whipple disease 10.5 TNF CRP CD4
45 idiopathic anterior uveitis 10.5 TNF IL6
46 ventilation pneumonitis 10.5 CD8A CD4
47 histoplasmosis 10.5 TNF CD4 CCR6
48 keratoconjunctivitis sicca 10.5 TNF CD4 CCR6
49 coronary aneurysm 10.5 TNF IL6 CRP
50 chondromalacia 10.5 TNF IL6 CRP

Graphical network of the top 20 diseases related to Autoimmune Disease of Skin and Connective Tissue:



Diseases related to Autoimmune Disease of Skin and Connective Tissue

Symptoms & Phenotypes for Autoimmune Disease of Skin and Connective Tissue

MGI Mouse Phenotypes related to Autoimmune Disease of Skin and Connective Tissue:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 CCR6 CD4 CRP CTLA4 DSG1 DSG3
2 hematopoietic system MP:0005397 10.25 CCR6 CD4 CD8A CTLA4 DSG3 IL10
3 immune system MP:0005387 10.17 CCR6 CD4 CD8A CRP CTLA4 DSG3
4 endocrine/exocrine gland MP:0005379 10.13 CD4 CD8A CTLA4 IL10 IL17A IL2
5 digestive/alimentary MP:0005381 10.11 CD4 CTLA4 DSG3 IL10 IL17A IL2
6 integument MP:0010771 10.07 CD4 CD8A CTLA4 DSG1 DSG3 IL10
7 neoplasm MP:0002006 9.76 IL10 IL1B IL2 IL23R IL6 TNF
8 no phenotypic analysis MP:0003012 9.56 CD4 IL10 IL17A IL2 IL23R PMEL
9 skeleton MP:0005390 9.32 CTLA4 DSG1 DSG3 IL10 IL17A IL1B

Drugs & Therapeutics for Autoimmune Disease of Skin and Connective Tissue

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Skin and Connective Tissue

Genetic Tests for Autoimmune Disease of Skin and Connective Tissue

Anatomical Context for Autoimmune Disease of Skin and Connective Tissue

MalaCards organs/tissues related to Autoimmune Disease of Skin and Connective Tissue:

40
Skin, T Cells

Publications for Autoimmune Disease of Skin and Connective Tissue

Variations for Autoimmune Disease of Skin and Connective Tissue

Expression for Autoimmune Disease of Skin and Connective Tissue

Search GEO for disease gene expression data for Autoimmune Disease of Skin and Connective Tissue.

Pathways for Autoimmune Disease of Skin and Connective Tissue

Pathways related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 TNF IL6 IL23R IL2 IL1B IL17A
2
Show member pathways
13.85 TNF IL6 IL23R IL2 IL1B IL17A
3
Show member pathways
13.71 TNF IL6 IL23R IL2 IL1B IL17A
4
Show member pathways
13.44 TNF IL6 IL23R IL2 IL1B IL17A
5
Show member pathways
13.39 TNF IL6 IL23R IL2 IL1B IL17A
6
Show member pathways
13.33 TNF IL6 IL23R IL2 IL1B IL17A
7
Show member pathways
12.76 TNF IL6 IL2 IL1B IL17A IL10
8
Show member pathways
12.66 TNF IL2 IL10 ICOSLG CD4
9
Show member pathways
12.62 TNF IL6 IL23R IL2 IL1B IL17A
10
Show member pathways
12.59 TNF IL6 IL23R IL2 IL1B IL17A
11 12.58 TNF IL2 IL1B IL17A IL10 CTLA4
12
Show member pathways
12.56 TNF IL6 IL2 IL1B IL17A IL10
13
Show member pathways
12.4 IL2 ICOSLG CTLA4 CD4
14
Show member pathways
12.39 TNF IL6 IL2 IL10 CCR6
15
Show member pathways
12.38 TNF IL6 IL2 IL1B CRP
16 12.36 TNF IL6 IL2 CD4
17
Show member pathways
12.35 TNF IL6 IL1B IL17A
18
Show member pathways
12.31 TNF IL6 IL2 IL1B IL17A IL10
19
Show member pathways
12.27 TNF IL6 IL2 IL1B IL10
20 12.26 TNF IL6 IL1B IL10
21 12.2 TNF IL6 IL1B IL10
22 12.16 ICOSLG CTLA4 CD8A CD4
23 12.08 TNF IL6 IL2 IL1B IL10 CD8A
24 12.05 TNF IL6 IL2 IL1B
25 12.05 TNF IL6 IL2 IL10 CD8A CD4
26 12.03 TNF IL6 IL23R IL1B IL17A IL10
27
Show member pathways
12.02 IL2 IL1B CD8A CD4
28 11.97 TNF IL6 IL1B IL10
29 11.96 TNF IL6 IL1B CD8A CD4
30 11.91 TNF IL6 IL1B IL17A CTLA4
31
Show member pathways
11.89 IL6 IL23R IL1B IL17A CD4
32 11.82 TNF IL6 IL1B IL10
33
Show member pathways
11.78 TNF IL2 CTLA4
34 11.75 CTLA4 CD8A CD4
35 11.73 TNF IL6 IL10 ICOSLG CTLA4 CCR6
36
Show member pathways
11.72 TNF IL6 IL2 IL1B
37 11.69 TNF IL6 IL1B
38
Show member pathways
11.68 TNF IL6 IL2 IL1B IL17A IL10
39
Show member pathways
11.67 TNF IL2 CD8A
40 11.64 TNF IL6 IL1B
41 11.61 TNF IL6 IL1B IL10
42 11.59 TNF IL6 IL1B IL10
43 11.58 TNF IL6 IL2
44 11.57 TNF IL6 IL2 IL1B IL10 CD8A
45 11.55 TNF IL2 IL1B
46 11.53 IL2 IL10 CD4
47 11.52 TNF IL6 IL1B
48 11.45 TNF IL6 IL1B IL10
49 11.42 TNF IL6 IL1B IL10
50
Show member pathways
11.41 TNF IL2 IL10

GO Terms for Autoimmune Disease of Skin and Connective Tissue

Cellular components related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10 TYRP1 TYR TNF PMEL IL23R ICOSLG
2 extracellular region GO:0005576 9.65 TNF PMEL IL6 IL2 IL1B IL17A
3 hemidesmosome GO:0030056 9.26 DST COL17A1
4 external side of plasma membrane GO:0009897 9.23 TNF IL23R IL17A ICOSLG CTLA4 CD8A

Biological processes related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.16 IL23R IL2 IL17A ICOSLG CTLA4 CD8A
2 adaptive immune response GO:0002250 10.07 IL2 IL17A ICOSLG CTLA4 CD8A CD4
3 inflammatory response GO:0006954 10 TNF IL6 IL23R IL1B IL17A CRP
4 positive regulation of protein phosphorylation GO:0001934 9.97 TNF IL2 IL1B CD4
5 cellular response to lipopolysaccharide GO:0071222 9.95 TNF IL6 IL1B IL10
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 TNF IL6 IL1B IL10
7 defense response to Gram-positive bacterium GO:0050830 9.9 TNF IL6 IL17A CRP
8 positive regulation of interleukin-6 production GO:0032755 9.86 TNF IL6 IL1B IL17A
9 regulation of insulin secretion GO:0050796 9.85 TNF IL6 IL1B
10 response to glucocorticoid GO:0051384 9.85 TNF IL6 IL10
11 defense response to Gram-negative bacterium GO:0050829 9.85 IL6 IL23R IL17A CD4
12 positive regulation of interleukin-8 production GO:0032757 9.84 TNF IL6 IL1B
13 humoral immune response GO:0006959 9.84 TNF IL6 CCR6
14 positive regulation of interleukin-1 beta production GO:0032731 9.83 TNF IL6 IL17A
15 T cell activation GO:0042110 9.82 ICOSLG CD8A CD4
16 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF IL6 IL10
17 positive regulation of activated T cell proliferation GO:0042104 9.78 IL23R IL2 ICOSLG
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 TNF IL6 IL23R IL2
19 negative regulation of neurogenesis GO:0050768 9.76 TNF IL6 IL1B
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.75 TNF IL6 IL17A
21 positive regulation of osteoclast differentiation GO:0045672 9.74 TNF IL23R IL17A
22 positive regulation of interferon-gamma production GO:0032729 9.73 TNF IL23R IL2 IL1B
23 positive regulation of immunoglobulin production GO:0002639 9.71 IL6 IL2 IL10
24 positive regulation of glial cell proliferation GO:0060252 9.69 TNF IL6 IL1B
25 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
26 endothelial cell apoptotic process GO:0072577 9.67 TNF IL10
27 positive regulation of interleukin-17 production GO:0032740 9.67 IL6 IL23R IL2
28 negative regulation of cytokine production involved in immune response GO:0002719 9.65 TNF IL10
29 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
30 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
31 positive regulation of plasma cell differentiation GO:1900100 9.63 IL2 IL10
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IL1B
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF IL1B IL10
34 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
35 cytokine-mediated signaling pathway GO:0019221 9.56 TNF IL6 IL23R IL2 IL1B IL17A
36 positive regulation of T cell proliferation GO:0042102 9.55 IL6 IL23R IL2 IL1B CD4
37 melanin biosynthetic process GO:0042438 9.54 TYRP1 TYR PMEL
38 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
39 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
40 immune response GO:0006955 9.32 TNF IL6 IL2 IL1B IL17A IL10

Molecular functions related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL6 IL2 IL1B IL17A IL10
2 monophenol monooxygenase activity GO:0004503 8.96 TYRP1 TYR

Sources for Autoimmune Disease of Skin and Connective Tissue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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