Autoimmune Disease of Skin and Connective Tissue disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ATM016 MIFTS: 31	Autoimmune Disease of Skin and Connective Tissue Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Autoimmune Disease of Skin and Connective Tissue

MalaCards integrated aliases for Autoimmune Disease of Skin and Connective Tissue:

Name: Autoimmune Disease of Skin and Connective Tissue ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060039

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Summaries for Autoimmune Disease of Skin and Connective Tissue

Disease Ontology : ¹² An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue.

MalaCards based summary : Autoimmune Disease of Skin and Connective Tissue is related to pemphigoid and pemphigus. An important gene associated with Autoimmune Disease of Skin and Connective Tissue is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin and t cells, and related phenotypes are homeostasis/metabolism and hematopoietic system

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Related Diseases for Autoimmune Disease of Skin and Connective Tissue

Diseases related to Autoimmune Disease of Skin and Connective Tissue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 806)

#	Related Disease	Score	Top Affiliating Genes
1	pemphigoid	32.6	TNF IL1B DST COL17A1
2	pemphigus	32.3	TNF IL6 IL10 DST DSG3 DSG1
3	neurosyphilis	10.6	IL17A IL10
4	coccidioidomycosis	10.6	IL17A CD4 CCR6
5	external pathological resorption	10.6	TNF IL6
6	lichen planus pemphigoides	10.6	DST COL17A1
7	cork-handlers' disease	10.6	CD8A CD4
8	necrotic uveal melanoma	10.6	CD8A CD4
9	scorpion envenomation	10.6	TNF IL6
10	adult acute lymphocytic leukemia	10.6	CD8A CD4 CCR6
11	drug reaction with eosinophilia and systemic symptoms	10.6	TNF CRP
12	punctate inner choroidopathy	10.5	TNF IL10
13	type 1 diabetes mellitus 23	10.5	TNF CD8A CD4
14	tropical endomyocardial fibrosis	10.5	TNF IL10
15	suppurative lymphadenitis	10.5	CRP CD4 CCR6
16	norwegian scabies	10.5	IL17A CD8A CD4
17	toxic megacolon	10.5	TNF CRP CCR6
18	early yaws	10.5	CD8A CD4
19	rheumatoid arthritis interstitial lung disease	10.5	TNF CRP CD4
20	opportunistic bacterial infectious disease	10.5	TNF CRP CD4
21	granulomatous dermatitis	10.5	TNF CD8A CD4
22	nocardiosis	10.5	TNF CRP CD4
23	enthesopathy	10.5	TNF CRP CCR6
24	dermatophytosis	10.5	IL17A CD4 CCR6
25	primary syphilis	10.5	CRP CD8A CD4
26	gastrointestinal tuberculosis	10.5	TNF CRP CD4
27	intestinal tuberculosis	10.5	TNF CRP CD4
28	uveoparotid fever	10.5	TNF CD8A CD4
29	toxicodendron dermatitis	10.5	TNF IL2 CD8A
30	fasciitis	10.5	TNF IL6 IL2
31	mononeuritis of upper limb and mononeuritis multiplex	10.5	TNF CRP CD4
32	mononeuritis multiplex	10.5	TNF CRP CD4
33	lymph node tuberculosis	10.5	TNF CRP CD4
34	systemic autoimmune disease	10.5	IL6 IL17A CRP
35	immunodeficiency with hyper-igm, type 3	10.5	ICOSLG CD8A CD4
36	retinal vasculitis	10.5	TNF CD4 CCR6
37	abdominal tuberculosis	10.5	TNF CRP CD4
38	physiological polycythemia	10.5	TNF IL6 IL1B
39	secondary syphilis	10.5	CRP CD8A CD4
40	streptococcal toxic-shock syndrome	10.5	TNF IL6 IL2
41	parotid disease	10.5	CRP CD8A CD4
42	igg4-related disease	10.5	ICOSLG CRP CCR6
43	mucormycosis	10.5	CRP CD4 CCR6
44	whipple disease	10.5	TNF CRP CD4
45	idiopathic anterior uveitis	10.5	TNF IL6
46	ventilation pneumonitis	10.5	CD8A CD4
47	histoplasmosis	10.5	TNF CD4 CCR6
48	keratoconjunctivitis sicca	10.5	TNF CD4 CCR6
49	coronary aneurysm	10.5	TNF IL6 CRP
50	chondromalacia	10.5	TNF IL6 CRP

Graphical network of the top 20 diseases related to Autoimmune Disease of Skin and Connective Tissue:

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Symptoms & Phenotypes for Autoimmune Disease of Skin and Connective Tissue

MGI Mouse Phenotypes related to Autoimmune Disease of Skin and Connective Tissue:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.27	CCR6 CD4 CRP CTLA4 DSG1 DSG3
2	hematopoietic system	MP:0005397	10.25	CCR6 CD4 CD8A CTLA4 DSG3 IL10
3	immune system	MP:0005387	10.17	CCR6 CD4 CD8A CRP CTLA4 DSG3
4	endocrine/exocrine gland	MP:0005379	10.13	CD4 CD8A CTLA4 IL10 IL17A IL2
5	digestive/alimentary	MP:0005381	10.11	CD4 CTLA4 DSG3 IL10 IL17A IL2
6	integument	MP:0010771	10.07	CD4 CD8A CTLA4 DSG1 DSG3 IL10
7	neoplasm	MP:0002006	9.76	IL10 IL1B IL2 IL23R IL6 TNF
8	no phenotypic analysis	MP:0003012	9.56	CD4 IL10 IL17A IL2 IL23R PMEL
9	skeleton	MP:0005390	9.32	CTLA4 DSG1 DSG3 IL10 IL17A IL1B

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Drugs & Therapeutics for Autoimmune Disease of Skin and Connective Tissue

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Skin and Connective Tissue

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Genetic Tests for Autoimmune Disease of Skin and Connective Tissue

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Anatomical Context for Autoimmune Disease of Skin and Connective Tissue

MalaCards organs/tissues related to Autoimmune Disease of Skin and Connective Tissue:

⁴⁰

Skin, T Cells

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Publications for Autoimmune Disease of Skin and Connective Tissue

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Genes for Autoimmune Disease of Skin and Connective Tissue

Genes related to Autoimmune Disease of Skin and Connective Tissue (0 elite genes):

(show all 45)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	13.15	DISEASES inferred ¹⁵ ¹⁵
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.94	DISEASES inferred ¹⁵ ¹⁵
3	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	9.56	DISEASES inferred ¹⁵
4	DST	Dystonin	Protein Coding	9.24	DISEASES inferred ¹⁵
5	TNF	Tumor Necrosis Factor	Protein Coding	8.78	DISEASES inferred ¹⁵
6	IL17A	Interleukin 17A	Protein Coding	8.66	DISEASES inferred ¹⁵
7	CD8A	CD8a Molecule	Protein Coding	8.12	DISEASES inferred ¹⁵
8	CD4	CD4 Molecule	Protein Coding	8.11	DISEASES inferred ¹⁵
9	TYR	Tyrosinase	Protein Coding	8.04	DISEASES inferred ¹⁵
10	CRP	C-Reactive Protein	Protein Coding	7.78	DISEASES inferred ¹⁵
11	IL6	Interleukin 6	Protein Coding	7.74	DISEASES inferred ¹⁵
12	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	7.74	DISEASES inferred ¹⁵
13	PMEL	Premelanosome Protein	Protein Coding	7.65	DISEASES inferred ¹⁵
14	IL2	Interleukin 2	Protein Coding	7.63	DISEASES inferred ¹⁵
15	DSG3	Desmoglein 3	Protein Coding	7.51	DISEASES inferred ¹⁵
16	IL23R	Interleukin 23 Receptor	Protein Coding	7.48	DISEASES inferred ¹⁵
17	DSG1	Desmoglein 1	Protein Coding	7.45	DISEASES inferred ¹⁵
18	IL1B	Interleukin 1 Beta	Protein Coding	7.4	DISEASES inferred ¹⁵
19	IL10	Interleukin 10	Protein Coding	7.4	DISEASES inferred ¹⁵
20	TYRP1	Tyrosinase Related Protein 1	Protein Coding	7.4	DISEASES inferred ¹⁵
21	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	7.33	DISEASES inferred ¹⁵
22	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	7.3	DISEASES inferred ¹⁵
23	DCT	Dopachrome Tautomerase	Protein Coding	7.29	DISEASES inferred ¹⁵
24	IL4	Interleukin 4	Protein Coding	7.27	DISEASES inferred ¹⁵
25	PDE4A	Phosphodiesterase 4A	Protein Coding	7.26	DISEASES inferred ¹⁵
26	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	7.25	DISEASES inferred ¹⁵
27	IL17F	Interleukin 17F	Protein Coding	7.25	DISEASES inferred ¹⁵
28	AIRE	Autoimmune Regulator	Protein Coding	7.21	DISEASES inferred ¹⁵
29	SERPINA3	Serpin Family A Member 3	Protein Coding	7.2	DISEASES inferred ¹⁵ ¹⁵
30	H2AC18	H2A Clustered Histone 18	Protein Coding	7.15	DISEASES inferred ¹⁵ ¹⁵
31	FOXP3	Forkhead Box P3	Protein Coding	7.14	DISEASES inferred ¹⁵
32	IL17RA	Interleukin 17 Receptor A	Protein Coding	7.13	DISEASES inferred ¹⁵
33	TOR1A	Torsin Family 1 Member A	Protein Coding	7.12	DISEASES inferred ¹⁵
34	PLEC	Plectin	Protein Coding	7.12	DISEASES inferred ¹⁵
35	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	7.11	DISEASES inferred ¹⁵
36	TGM2	Transglutaminase 2	Protein Coding	7.08	DISEASES inferred ¹⁵
37	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	7.06	DISEASES inferred ¹⁵
38	IFNG	Interferon Gamma	Protein Coding	7.02	DISEASES inferred ¹⁵
39	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	7.01	DISEASES inferred ¹⁵
40	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	6.93	DISEASES inferred ¹⁵
41	TRAF3IP2	TRAF3 Interacting Protein 2	Protein Coding	6.89	DISEASES inferred ¹⁵
42	CSF2	Colony Stimulating Factor 2	Protein Coding	6.88	DISEASES inferred ¹⁵
43	ERAP1	Endoplasmic Reticulum Aminopeptidase 1	Protein Coding	6.88	DISEASES inferred ¹⁵
44	IL13	Interleukin 13	Protein Coding	6.87	DISEASES inferred ¹⁵
45	IL15	Interleukin 15	Protein Coding	6.87	DISEASES inferred ¹⁵

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Variations for Autoimmune Disease of Skin and Connective Tissue

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Expression for Autoimmune Disease of Skin and Connective Tissue

Search GEO for disease gene expression data for Autoimmune Disease of Skin and Connective Tissue.

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Pathways for Autoimmune Disease of Skin and Connective Tissue

Pathways related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.03	TNF IL6 IL23R IL2 IL1B IL17A
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.85	TNF IL6 IL23R IL2 IL1B IL17A
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.71	TNF IL6 IL23R IL2 IL1B IL17A
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.44	TNF IL6 IL23R IL2 IL1B IL17A
5	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.39	TNF IL6 IL23R IL2 IL1B IL17A
6	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.33	TNF IL6 IL23R IL2 IL1B IL17A
7	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.76	TNF IL6 IL2 IL1B IL17A IL10
8	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.66	TNF IL2 IL10 ICOSLG CD4
9	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.62	TNF IL6 IL23R IL2 IL1B IL17A
10	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.59	TNF IL6 IL23R IL2 IL1B IL17A
11	NF-kappaB Signaling ⁴	12.58	TNF IL2 IL1B IL17A IL10 CTLA4
12	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.56	TNF IL6 IL2 IL1B IL17A IL10
13	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.4	IL2 ICOSLG CTLA4 CD4
14	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.39	TNF IL6 IL2 IL10 CCR6
15	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.38	TNF IL6 IL2 IL1B CRP
16	Human T-cell leukemia virus 1 infection ³⁶	12.36	TNF IL6 IL2 CD4
17	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.35	TNF IL6 IL1B IL17A
18	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.31	TNF IL6 IL2 IL1B IL17A IL10
19	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	12.27	TNF IL6 IL2 IL1B IL10
20	Tuberculosis ³⁶	12.26	TNF IL6 IL1B IL10
21	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.2	TNF IL6 IL1B IL10
22	Cell adhesion molecules ³⁶	12.16	ICOSLG CTLA4 CD8A CD4
23	Yersinia infection ³⁶	12.08	TNF IL6 IL2 IL1B IL10 CD8A
24	Spinal Cord Injury ¹	12.05	TNF IL6 IL2 IL1B
25	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	12.05	TNF IL6 IL2 IL10 CD8A CD4
26	Interleukin-4 and 13 signaling ⁶⁵	12.03	TNF IL6 IL23R IL1B IL17A IL10
27	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	12.02	IL2 IL1B CD8A CD4
28	Amoebiasis ³⁶	11.97	TNF IL6 IL1B IL10
29	Hematopoietic cell lineage ³⁶	11.96	TNF IL6 IL1B CD8A CD4
30	Rheumatoid arthritis ³⁶	11.91	TNF IL6 IL1B IL17A CTLA4
31	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.89	IL6 IL23R IL1B IL17A CD4
32	Pertussis ³⁶	11.82	TNF IL6 IL1B IL10
33	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.78	TNF IL2 CTLA4
34	CTLA4 Signaling ⁶³	11.75	CTLA4 CD8A CD4
35	IgA-Producing B Cells in the Intestine ⁶⁴	11.73	TNF IL6 IL10 ICOSLG CTLA4 CCR6
36	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.72	TNF IL6 IL2 IL1B
37	Lung fibrosis ¹	11.69	TNF IL6 IL1B
38	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.68	TNF IL6 IL2 IL1B IL17A IL10
39	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.67	TNF IL2 CD8A
40	Legionellosis ³⁶	11.64	TNF IL6 IL1B
41	Malaria ³⁶	11.61	TNF IL6 IL1B IL10
42	Interleukin-10 signaling ⁶⁵	11.59	TNF IL6 IL1B IL10
43	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.58	TNF IL6 IL2
44	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.57	TNF IL6 IL2 IL1B IL10 CD8A
45	Aryl Hydrocarbon Receptor Pathway ¹	11.55	TNF IL2 IL1B
46	Th2 Differentiation Pathway ⁶⁴	11.53	IL2 IL10 CD4
47	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.52	TNF IL6 IL1B
48	African trypanosomiasis ³⁶	11.45	TNF IL6 IL1B IL10
49	IL-10 Pathway ⁶³	11.42	TNF IL6 IL1B IL10
50	IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Show member pathways IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.41	TNF IL2 IL10

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GO Terms for Autoimmune Disease of Skin and Connective Tissue

Cellular components related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of membrane	GO:0016021	10	TYRP1 TYR TNF PMEL IL23R ICOSLG
2	extracellular region	GO:0005576	9.65	TNF PMEL IL6 IL2 IL1B IL17A
3	hemidesmosome	GO:0030056	9.26	DST COL17A1
4	external side of plasma membrane	GO:0009897	9.23	TNF IL23R IL17A ICOSLG CTLA4 CD8A

Biological processes related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

(show all 40)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	10.16	IL23R IL2 IL17A ICOSLG CTLA4 CD8A
2	adaptive immune response	GO:0002250	10.07	IL2 IL17A ICOSLG CTLA4 CD8A CD4
3	inflammatory response	GO:0006954	10	TNF IL6 IL23R IL1B IL17A CRP
4	positive regulation of protein phosphorylation	GO:0001934	9.97	TNF IL2 IL1B CD4
5	cellular response to lipopolysaccharide	GO:0071222	9.95	TNF IL6 IL1B IL10
6	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.92	TNF IL6 IL1B IL10
7	defense response to Gram-positive bacterium	GO:0050830	9.9	TNF IL6 IL17A CRP
8	positive regulation of interleukin-6 production	GO:0032755	9.86	TNF IL6 IL1B IL17A
9	regulation of insulin secretion	GO:0050796	9.85	TNF IL6 IL1B
10	response to glucocorticoid	GO:0051384	9.85	TNF IL6 IL10
11	defense response to Gram-negative bacterium	GO:0050829	9.85	IL6 IL23R IL17A CD4
12	positive regulation of interleukin-8 production	GO:0032757	9.84	TNF IL6 IL1B
13	humoral immune response	GO:0006959	9.84	TNF IL6 CCR6
14	positive regulation of interleukin-1 beta production	GO:0032731	9.83	TNF IL6 IL17A
15	T cell activation	GO:0042110	9.82	ICOSLG CD8A CD4
16	positive regulation of JAK-STAT cascade	GO:0046427	9.8	TNF IL6 IL10
17	positive regulation of activated T cell proliferation	GO:0042104	9.78	IL23R IL2 ICOSLG
18	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.78	TNF IL6 IL23R IL2
19	negative regulation of neurogenesis	GO:0050768	9.76	TNF IL6 IL1B
20	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.75	TNF IL6 IL17A
21	positive regulation of osteoclast differentiation	GO:0045672	9.74	TNF IL23R IL17A
22	positive regulation of interferon-gamma production	GO:0032729	9.73	TNF IL23R IL2 IL1B
23	positive regulation of immunoglobulin production	GO:0002639	9.71	IL6 IL2 IL10
24	positive regulation of glial cell proliferation	GO:0060252	9.69	TNF IL6 IL1B
25	regulation of establishment of endothelial barrier	GO:1903140	9.68	TNF IL1B
26	endothelial cell apoptotic process	GO:0072577	9.67	TNF IL10
27	positive regulation of interleukin-17 production	GO:0032740	9.67	IL6 IL23R IL2
28	negative regulation of cytokine production involved in immune response	GO:0002719	9.65	TNF IL10
29	positive regulation of fever generation	GO:0031622	9.65	TNF IL1B
30	sequestering of triglyceride	GO:0030730	9.64	TNF IL1B
31	positive regulation of plasma cell differentiation	GO:1900100	9.63	IL2 IL10
32	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.63	TNF IL1B
33	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.63	TNF IL1B IL10
34	positive regulation of neuroinflammatory response	GO:0150078	9.58	TNF IL6 IL1B
35	cytokine-mediated signaling pathway	GO:0019221	9.56	TNF IL6 IL23R IL2 IL1B IL17A
36	positive regulation of T cell proliferation	GO:0042102	9.55	IL6 IL23R IL2 IL1B CD4
37	melanin biosynthetic process	GO:0042438	9.54	TYRP1 TYR PMEL
38	negative regulation of lipid storage	GO:0010888	9.5	TNF IL6 CRP
39	vascular endothelial growth factor production	GO:0010573	9.43	TNF IL6 IL1B
40	immune response	GO:0006955	9.32	TNF IL6 IL2 IL1B IL17A IL10

Molecular functions related to Autoimmune Disease of Skin and Connective Tissue according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.1	TNF IL6 IL2 IL1B IL17A IL10
2	monophenol monooxygenase activity	GO:0004503	8.96	TYRP1 TYR

Sources

Sources for Autoimmune Disease of Skin and Connective Tissue

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia