MCID: ATM017
MIFTS: 37

Autoimmune Disease of the Nervous System

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Disease of the Nervous System

MalaCards integrated aliases for Autoimmune Disease of the Nervous System:

Name: Autoimmune Disease of the Nervous System 12 15
Autoimmune Diseases of the Nervous System 44
Autoimmune Nervous System Disorder 12
Autoimmune Diseases Nervous System 54

Classifications:



External Ids:

Disease Ontology 12 DOID:438
MeSH 44 D020274
NCIt 50 C99383
UMLS 71 C0751871

Summaries for Autoimmune Disease of the Nervous System

Disease Ontology : 12 An autoimmune disease affecting the nervous system.

MalaCards based summary : Autoimmune Disease of the Nervous System, also known as autoimmune diseases of the nervous system, is related to autoimmune disease of peripheral nervous system and autoimmune disease. An important gene associated with Autoimmune Disease of the Nervous System is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Mitoxantrone and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include thymus and t cells.

Related Diseases for Autoimmune Disease of the Nervous System

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease Autoimmune Disease of the Nervous System
Infectious Disease of the Nervous System

Diseases related to Autoimmune Disease of the Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 581)
# Related Disease Score Top Affiliating Genes
1 autoimmune disease of peripheral nervous system 32.5 MOG MBP IL17A IL10 IFNB1 ICOSLG
2 autoimmune disease 31.3 TNF MOG MBP IL17A IL10 IFNB1
3 neuromyelitis optica 31.2 MOG MBP IL17A AQP4
4 encephalitis 31.2 TNF MOG IL10 IFNB1 AQP4
5 guillain-barre syndrome 31.2 TNF MOG MBP IL17A
6 neuritis 31.0 TNF MOG MBP IL10 AQP4
7 chronic inflammatory demyelinating polyradiculoneuropathy 31.0 MBP IL17A IL10 IFNB1 ICOSLG
8 multiple sclerosis 30.7 TNF MOG MIR223 MIR155 MIR142 MBP
9 myasthenia gravis 11.2
10 neurosyphilis 10.7 IL17A IL10
11 polyradiculoneuropathy 10.6 MBP IL17A IL10
12 schistosomiasis 10.6 TNF IL17A IL10
13 dermatomyositis 10.6 MIR223 MIR155 MIR132
14 polyradiculopathy 10.6 MBP ICOSLG CD4
15 autoimmune optic neuritis 10.6 MOG MBP AQP4
16 balo concentric sclerosis 10.6 MOG MBP IFNB1 AQP4
17 herpes simplex virus keratitis 10.6 IFNB1 CD4 CCR6
18 cutaneous leishmaniasis 10.6 TNF IL17A IL10
19 internuclear ophthalmoplegia 10.6 MOG MBP IFNB1 AQP4
20 progressive relapsing multiple sclerosis 10.6 SERPINA3 IFNB1 H2AC18 CCR6
21 scabies 10.6 IL10 CD4 CCR6
22 optic papillitis 10.6 MOG CD4 AQP4
23 mikulicz disease 10.6 IL10 CD4 CCR6
24 immunodeficiency with hyper-igm, type 1 10.6 ICOSLG H2AC18 CD4 CCR6
25 chlamydia 10.6 TNF IL17A IL10
26 legume allergy 10.6 IL10 ICOSLG CD4 CCR6
27 fruit allergy 10.6 IL10 ICOSLG CD4 CCR6
28 blastomycosis 10.6 IL17A CD4 CCR6
29 pharyngitis 10.6 TNF CD8A CD4
30 pre-malignant neoplasm 10.6 SERPINA3 MIR142 H2AC18 CCR6
31 immunodeficiency 16 10.6 ICOSLG CD8A CD4 CCR6
32 autoimmune glomerulonephritis 10.6 ICOSLG CD8A CD4 CCR6
33 immunodeficiency 35 10.6 IL10 ICOSLG CCR6
34 childhood type dermatomyositis 10.6 TNF ICOSLG CD4 CCR6
35 meningovascular neurosyphilis 10.6 TNF MBP IL17A CD4
36 evans' syndrome 10.6 MIR142 IL10 CD4 CCR6
37 punctate inner choroidopathy 10.6 TNF IL10
38 dysgammaglobulinemia 10.6 MBP ICOSLG CD8A
39 subcutaneous mycosis 10.6 IL17A IL10 CD4 CCR6
40 inclusion body myositis 10.6 SERPINA3 MIR223 MIR155 ICOSLG
41 arachnoiditis 10.6 TNF CD4 AQP4
42 monoclonal gammopathy of uncertain significance 10.6 U2AF1 TNF ICOSLG CCR6
43 sialadenitis 10.6 TNF ICOSLG CD4 CCR6
44 cardiovascular organ benign neoplasm 10.6 SERPINA3 MIR132 H2AC18 CCR6
45 respiratory allergy 10.6 IL10 ICOSLG CD4 CCR6
46 dermatophytosis 10.6 IL17A CD4 CCR6
47 pustulosis of palm and sole 10.6 TNF IL17A CCR6
48 inflammatory bowel disease 18 10.6 IL17A IL10 CCR6
49 retinal vasculitis 10.6 TNF IFNB1 CD4 CCR6
50 gastrointestinal system benign neoplasm 10.6 SERPINA3 MIR142 H2AC18 CCR6

Graphical network of the top 20 diseases related to Autoimmune Disease of the Nervous System:



Diseases related to Autoimmune Disease of the Nervous System

Symptoms & Phenotypes for Autoimmune Disease of the Nervous System

Drugs & Therapeutics for Autoimmune Disease of the Nervous System

Drugs for Autoimmune Disease of the Nervous System (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
2 Analgesics Phase 4
3
Melphalan Approved Phase 2 148-82-3 4053 460612
4
Etoposide Approved Phase 2 33419-42-0 36462
5
Carmustine Approved, Investigational Phase 2 154-93-8 2578
6
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
7
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
8
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
9
Adenosine Approved, Investigational Phase 1, Phase 2 58-61-7 60961
10
Emtricitabine Approved, Investigational Phase 1, Phase 2 143491-57-0 60877
11
Abacavir Approved, Investigational Phase 2 136470-78-5 65140 441300
12
Lamivudine Approved, Investigational Phase 2 134678-17-4 60825
13
Zidovudine Approved Phase 2 30516-87-1 35370
14
Phenylalanine Approved, Investigational, Nutraceutical Phase 2 63-91-2 6140
15
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
16
Cortisone Experimental Phase 2 53-06-5 222786
17
Tenofovir Experimental, Investigational Phase 1, Phase 2 147127-20-6 464205
18 Keratolytic Agents Phase 2
19 Anti-Inflammatory Agents Phase 2
20 Etoposide phosphate Phase 2
21 Antimitotic Agents Phase 2
22 Hormone Antagonists Phase 2
23 glucocorticoids Phase 2
24 Hormones Phase 2
25 Antilymphocyte Serum Phase 2
26 Thymoglobulin Phase 2
27 Nitrogen Mustard Compounds Phase 2
28 Dermatologic Agents Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Tubulin Modulators Phase 2
31 Podophyllotoxin Phase 2 518-28-5
32 Immunosuppressive Agents Phase 2
33 Alkylating Agents Phase 2
34 Protective Agents Phase 1, Phase 2
35 Antioxidants Phase 1, Phase 2
36 Janus Kinase Inhibitors Phase 2
37 Anti-Infective Agents Phase 1, Phase 2
38 Antimetabolites Phase 2
39 Antiviral Agents Phase 1, Phase 2
40 Anti-HIV Agents Phase 1, Phase 2
41 Reverse Transcriptase Inhibitors Phase 1, Phase 2
42 interferons Phase 1, Phase 2
43 Anti-Retroviral Agents Phase 1, Phase 2
44 Pharmaceutical Solutions Phase 2
45 Interferon Type I Phase 2
46 Dideoxynucleosides Phase 2
47 Immunologic Factors Phase 2
48 Immunoglobulins Phase 2
49 Antibodies Phase 2
50 Immunoglobulins, Intravenous Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease) Completed NCT00304291 Phase 4 Mitoxantrone
2 A Phase 2 Double-Blind, Placebo Controlled Multi-Center Study to Evaluate the Efficacy and Safety of Tcelna in Subjects With Secondary Progressive Multiple Sclerosis Completed NCT01684761 Phase 2
3 Multicenter Clinical Trial Phase I / II Randomized, Placebo-controlled Study to Evaluate Safety and Feasibility of Therapy With Two Different Doses of Autologous Mesenchymal Stem Cells in Patients With Secondary Progressive Multiple Sclerosis Who do Not Respond to Treatment Completed NCT01056471 Phase 1, Phase 2
4 A Pilot Clinical Trial of Reverse Transcriptase Inhibitors in Children With Aicardi-Goutières Syndrome (AGS) Completed NCT02363452 Phase 2 Reverse transcriptase inhibitors: Zidovudine, Lamivudine, Abacavir
5 High-Dose Immunosuppressive Therapy Using Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) + Thymoglobulin Followed by Syngeneic or Autologous Hematopoietic Cell Transplantation for Patients With Autoimmune Neurologic Diseases Recruiting NCT00716066 Phase 2 Carmustine;Cytarabine;Etoposide;Melphalan;Prednisone
6 Randomized, Single-blind, Placebo-controlled Clinical Trial to Evaluate the Safety and Efficacy of Melatonin Administration in Patients With Multiple Progressive Primary Sclerosis Recruiting NCT03540485 Phase 1, Phase 2 Melatonin
7 Janus Kinase Inhibitor (Baricitinib) for Aicardi Goutières Syndrome Active, not recruiting NCT03921554 Phase 2 Baricitinib
8 Reverse Transcriptase Inhibitors in Aicardi Goutières Syndrome Not yet recruiting NCT03304717 Phase 1, Phase 2 Tenofovir (TDF) and Emtricitabine (FTC)
9 Inhibition of Reverse Transcription in Type I Interferon Mediated Neuropathology Not yet recruiting NCT04731103 Phase 2 Abacavir (ABC);Lamivudine (3TC);Abacavir (ABC)+Lamivudine (3TC)+Zidovudine (AZT)
10 Aerobic Exercise to Improve Mobility in Multiple Sclerosis: Optimizing Design and Execution for a Full-scale Multimodal Remyelination Clinical Trial Not yet recruiting NCT04539002 Phase 1, Phase 2
11 IVIG Treatment for Refractory Immune-Related Adult Epilepsy Terminated NCT01545518 Phase 2 IVIG
12 An Open Label Clinical Trial to Evaluate the Safety and Efficacy of CT103A Cells for the Treatment of Relapsed/Refractory Antibody-associated Idiopathic Inflammatory Diseases of the Nervous System Recruiting NCT04561557 Early Phase 1 Cyclophosphamide and fludarabine
13 An Open-label, Non-Randomized, Multi-Center Study to Assess the Safety and Effects of Autologous Adipose-Derived Stromal Cells Delivered Intravenously Into Patients With Multiple Sclerosis Withdrawn NCT01453764

Search NIH Clinical Center for Autoimmune Disease of the Nervous System

Cochrane evidence based reviews: autoimmune diseases of the nervous system

Genetic Tests for Autoimmune Disease of the Nervous System

Anatomical Context for Autoimmune Disease of the Nervous System

MalaCards organs/tissues related to Autoimmune Disease of the Nervous System:

40
Thymus, T Cells

Publications for Autoimmune Disease of the Nervous System

Articles related to Autoimmune Disease of the Nervous System:

(show all 16)
# Title Authors PMID Year
1
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. 61
32353424 2020
2
Surveying sleep quality and fatigue in multiple sclerosis patients at a multiple sclerosis center in Kermanshah, Iran, in 2017. 61
32455178 2020
3
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature. 61
30568655 2018
4
Clinical efficacy and mechanism of lymphoplasma exchange in the treatment of Guillain-Barre syndrome. 61
29096750 2017
5
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ? 61
26637427 2015
6
[Research advances in pathogenesis of anti-N-methyl-D-aspartate receptor encephalitis]. 61
24927429 2014
7
Current immune therapies of autoimmune disease of the nervous system with special emphasis to multiple sclerosis. 61
22612753 2012
8
Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis. 61
21113195 2010
9
[Treatment of autoimmune myasthenia]. 61
19836041 2010
10
Rituximab levels in cerebrospinal fluid of patients with neurological autoimmune disorders. 61
18971221 2009
11
Molecular mimicry in neurological disease: what is the evidence? 61
18193392 2008
12
[Multiple sclerosis--difficult answers to easy questions]. 61
17103358 2006
13
The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus. 61
9199973 1997
14
T-cell receptors: germline polymorphism and patterns of usage in demyelinating diseases. 54
1382445 1992
15
The pathogenetic significance of cross reactions in autoimmune disease of the nervous system. 61
25290977 1984
16
Lupus erythematosus: an autoimmune disease of the nervous system? 61
4109092 1971

Variations for Autoimmune Disease of the Nervous System

Expression for Autoimmune Disease of the Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of the Nervous System.

Pathways for Autoimmune Disease of the Nervous System

GO Terms for Autoimmune Disease of the Nervous System

Cellular components related to Autoimmune Disease of the Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF SERPINA3 MIR223 MIR155 MIR142 MIR132
2 external side of plasma membrane GO:0009897 9.23 TNF MOG IL17A ICOSLG CD8A CD4

Biological processes related to Autoimmune Disease of the Nervous System according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.97 IL17A IFNB1 ICOSLG CD8A CD4
2 gene silencing by miRNA GO:0035195 9.88 MIR9-1 MIR223 MIR155 MIR142 MIR132 MIR124-1
3 cytokine-mediated signaling pathway GO:0019221 9.77 TNF IL17A IL10 IFNB1 CD4
4 humoral immune response GO:0006959 9.71 TNF IFNB1 CCR6
5 immune response GO:0006955 9.7 TNF MBP IL17A IL10 CD8A CD4
6 T cell activation GO:0042110 9.67 ICOSLG CD8A CD4
7 negative regulation of blood vessel endothelial cell migration GO:0043537 9.65 TNF MIR155 MIR132
8 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.63 MIR223 MIR124-1 IL10
9 miRNA mediated inhibition of translation GO:0035278 9.62 MIR9-1 MIR155 MIR132 MIR124-1
10 negative regulation of interleukin-8 production GO:0032717 9.61 MIR155 MIR132 IL10
11 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.58 MBP IL10
12 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.58 TNF MBP
13 negative regulation of vascular wound healing GO:0061044 9.56 TNF MIR155
14 negative regulation of interleukin-6 production GO:0032715 9.56 TNF MIR155 MIR132 IL10
15 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
16 negative regulation of cytokine production involved in immune response GO:0002719 9.52 TNF IL10
17 negative regulation of necrotic cell death GO:0060547 9.51 MIR223 MIR155
18 negative regulation of inflammatory response GO:0050728 9.35 MIR223 MIR155 MIR142 MIR124-1 IL10
19 negative regulation of bicellular tight junction assembly GO:1903347 8.8 TNF MIR155 MIR142

Molecular functions related to Autoimmune Disease of the Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL17A IL10 IFNB1
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR9-1 MIR223 MIR155 MIR142 MIR132 MIR124-1

Sources for Autoimmune Disease of the Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....