MCID: ATM018
MIFTS: 26

Autoimmune Disease of Urogenital Tract

Categories: Immune diseases

Aliases & Classifications for Autoimmune Disease of Urogenital Tract

MalaCards integrated aliases for Autoimmune Disease of Urogenital Tract:

Name: Autoimmune Disease of Urogenital Tract 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060049

Summaries for Autoimmune Disease of Urogenital Tract

Disease Ontology : 12 An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract.

MalaCards based summary : Autoimmune Disease of Urogenital Tract is related to autoimmune glomerulonephritis and purulent acute otitis media. An important gene associated with Autoimmune Disease of Urogenital Tract is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Phagosome and Small cell lung cancer. Affiliated tissues include skin, t cells and bone, and related phenotypes are Reduced mammosphere formation and immune system

Related Diseases for Autoimmune Disease of Urogenital Tract

Diseases related to Autoimmune Disease of Urogenital Tract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 396)
# Related Disease Score Top Affiliating Genes
1 autoimmune glomerulonephritis 31.4 ICOSLG FGL2 FCGR2B COL4A3 CD8A CD4
2 purulent acute otitis media 10.4 PRTN3 MPO
3 allergic cutaneous vasculitis 10.4 PRTN3 MPO
4 multiple cranial nerve palsy 10.4 PRTN3 MPO
5 acute frontal sinusitis 10.4 PRTN3 MPO
6 anca-associated vasculitis 10.4 PRTN3 MPO
7 glossopharyngeal nerve disease 10.4 PRTN3 MPO
8 wissler-fanconi syndrome 10.4 PRTN3 CD4
9 scleritis 10.4 PRTN3 MPO CCR6
10 progressive relapsing multiple sclerosis 10.3 H2AC18 CFHR2 CCR6
11 orbital granuloma 10.3 PRTN3 MPO FCGR2B
12 suppurative lymphadenitis 10.3 CD4 CCR6
13 igg4-related disease 10.3 PLA2R1 ICOSLG CCR6
14 riedel's fibrosing thyroiditis 10.3 CD4 ALB
15 legume allergy 10.3 ICOSLG CD4 CCR6
16 fruit allergy 10.3 ICOSLG CD4 CCR6
17 monoclonal gammopathy of uncertain significance 10.3 ICOSLG CFHR2 CCR6
18 chronic conjunctivitis 10.3 ICOSLG CD4 CCR6
19 mononeuritis of upper limb and mononeuritis multiplex 10.3 PRTN3 MPO CD4
20 mononeuritis multiplex 10.3 PRTN3 MPO CD4
21 alport syndrome 1, x-linked 10.3 COL4A5 COL4A4
22 childhood type dermatomyositis 10.3 ICOSLG CD4 CCR6
23 sialadenitis 10.3 ICOSLG CD4 CCR6
24 chronic maxillary sinusitis 10.3 PRTN3 MPO
25 respiratory allergy 10.3 ICOSLG CD4 CCR6
26 yellow nail syndrome 10.3 CCR6 ALB
27 cholangitis 10.3 PRTN3 MPO ALB
28 bullous skin disease 10.3 ICOSLG CD4 CCR6
29 urethral syndrome 10.3 H2AC18 CD4 CCR6
30 autoimmune neuropathy 10.3 ICOSLG FCGR2B CD4
31 cryptococcal meningitis 10.3 FCGR2B CD4 CCR6
32 multicentric castleman disease 10.3 H2AC18 CFHR2 CD4
33 agammaglobulinemia, x-linked 10.3 ICOSLG CD4 CCR6
34 x-linked alport syndrome 10.3 COL4A5 COL4A4 COL4A3
35 pierson syndrome 10.3 COL4A5 COL4A4 COL4A3
36 autosomal dominant alport syndrome 10.3 COL4A5 COL4A4 COL4A3
37 herpes simplex virus keratitis 10.3 CD4 CCR6
38 polyradiculopathy 10.3 ICOSLG CD4
39 epidural abscess 10.3 CD4 ALB
40 granulomatous myositis 10.3 PRTN3 CD8A
41 lymphadenitis 10.3 ICOSLG CD4 CCR6
42 necrotic uveal melanoma 10.3 CD8A CD4
43 porencephaly 10.2 COL4A5 COL4A4 COL4A3
44 leiomyomatosis 10.2 COL4A5 COL4A4 COL4A3
45 mucormycosis 10.2 CD4 CCR6 ALB
46 splenic tuberculosis 10.2 PRTN3 CD4 ALB
47 early yaws 10.2 CD8A CD4
48 lung abscess 10.2 PRTN3 CD4 ALB
49 c syndrome 10.2 CFHR2 CD4 ALB
50 cecal disease 10.2 CD4 CCR6 ALB

Graphical network of the top 20 diseases related to Autoimmune Disease of Urogenital Tract:



Diseases related to Autoimmune Disease of Urogenital Tract

Symptoms & Phenotypes for Autoimmune Disease of Urogenital Tract

GenomeRNAi Phenotypes related to Autoimmune Disease of Urogenital Tract according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 ALB CCR6 CD52 COL4A5 FCGR2A FGL2

MGI Mouse Phenotypes related to Autoimmune Disease of Urogenital Tract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.8 ALB CCR6 CD4 CD8A COL4A3 COL4A4
2 renal/urinary system MP:0005367 9.23 ALB CD8A COL4A3 COL4A4 COL4A5 FCGR2B

Drugs & Therapeutics for Autoimmune Disease of Urogenital Tract

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Urogenital Tract

Genetic Tests for Autoimmune Disease of Urogenital Tract

Anatomical Context for Autoimmune Disease of Urogenital Tract

MalaCards organs/tissues related to Autoimmune Disease of Urogenital Tract:

40
Skin, T Cells, Bone, Lung, Eye, Thymus, Bone Marrow

Publications for Autoimmune Disease of Urogenital Tract

Variations for Autoimmune Disease of Urogenital Tract

Expression for Autoimmune Disease of Urogenital Tract

Search GEO for disease gene expression data for Autoimmune Disease of Urogenital Tract.

Pathways for Autoimmune Disease of Urogenital Tract

GO Terms for Autoimmune Disease of Urogenital Tract

Cellular components related to Autoimmune Disease of Urogenital Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.01 PRTN3 MPO IL17A FGL2 COL4A5 COL4A4
2 collagen-containing extracellular matrix GO:0062023 9.77 PRTN3 FGL2 COL4A5 COL4A4 COL4A3
3 extracellular region GO:0005576 9.73 PRTN3 PLA2R1 MPO IL17A FGL2 COL4A5
4 endoplasmic reticulum lumen GO:0005788 9.72 COL4A5 COL4A4 COL4A3 CD4 ALB
5 external side of plasma membrane GO:0009897 9.63 IL17A ICOSLG FCGR2B CD8A CD4 CCR6
6 basement membrane GO:0005604 9.61 COL4A5 COL4A4 COL4A3
7 collagen trimer GO:0005581 9.56 COL4A5 COL4A4 COL4A3 CERT1
8 collagen type IV trimer GO:0005587 8.8 COL4A5 COL4A4 COL4A3

Biological processes related to Autoimmune Disease of Urogenital Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 9.43 ICOSLG CD8A CD4
2 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.37 COL4A5 COL4A3
3 cell surface receptor signaling pathway GO:0007166 9.35 FCGR2B FCGR2A COL4A3 CD8A CD4
4 glomerular basement membrane development GO:0032836 9.32 COL4A4 COL4A3
5 negative regulation of dendritic cell antigen processing and presentation GO:0002605 9.16 FGL2 FCGR2B
6 immune response GO:0006955 9.1 IL17A FCGR2B CERT1 CD8A CD4 CCR6

Molecular functions related to Autoimmune Disease of Urogenital Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 9.16 FCGR2B FCGR2A
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL4A5 COL4A4 COL4A3
3 extracellular matrix structural constituent GO:0005201 9.02 FGL2 COL4A5 COL4A4 COL4A3 CD4

Sources for Autoimmune Disease of Urogenital Tract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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