MCID: ATM018
MIFTS: 24

Autoimmune Disease of Urogenital Tract

Categories: Immune diseases

Aliases & Classifications for Autoimmune Disease of Urogenital Tract

MalaCards integrated aliases for Autoimmune Disease of Urogenital Tract:

Name: Autoimmune Disease of Urogenital Tract 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060049

Summaries for Autoimmune Disease of Urogenital Tract

Disease Ontology : 12 An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract.

MalaCards based summary : Autoimmune Disease of Urogenital Tract is related to autoimmune glomerulonephritis and antipyrine metabolism. An important gene associated with Autoimmune Disease of Urogenital Tract is DLAT (Dihydrolipoamide S-Acetyltransferase), and among its related pathways/superpathways are Metabolism and Selenium Micronutrient Network. Affiliated tissues include t cells, liver and pancreas, and related phenotype is digestive/alimentary.

Related Diseases for Autoimmune Disease of Urogenital Tract

Diseases related to Autoimmune Disease of Urogenital Tract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 autoimmune glomerulonephritis 11.2
2 antipyrine metabolism 10.2 ALB F2
3 non-a-e hepatitis 10.2 ALB F2
4 epstein-barr virus hepatitis 10.2 ALB F2
5 fournier gangrene 10.2 ALB F2
6 abdominal tuberculosis 10.2 ALB F2
7 background diabetic retinopathy 10.2 ALB TLR9
8 kwashiorkor 10.1 ALB F2
9 hepatic coma 10.1 ALB F2
10 infantile liver failure syndrome 1 10.1 ALB F2
11 hepatitis a 10.1 ALB F2 SEPSECS
12 halothane hepatitis 10.1 DLAT OGDH SEPSECS
13 choledocholithiasis 10.1 ABCB4 ALB F2
14 gastrointestinal system cancer 10.1 ALB F2 TLR9
15 endocrine gland cancer 10.1 ALB F2 TLR9
16 cholecystitis 10.1 ABCB4 ALB F2
17 splenic disease 10.1 ALB F2
18 immune system disease 10.1 ALB SCHIP1 TLR9
19 esophageal varix 10.1 ALB F2
20 crest syndrome 10.1 CENPB LBR
21 ascending cholangitis 10.0 ALB F2
22 sclerosing cholangitis 10.0 ABCB4 ALB GGT1
23 bilirubin metabolic disorder 10.0 ALB F2 GGT1
24 obstructive jaundice 10.0 ALB F2 GGT1
25 collagen disease 10.0 CENPB SCHIP1 TLR9
26 autoimmune hepatitis 10.0 DLAT F2 GGT1 SEPSECS
27 systemic scleroderma 9.9 CENPB SCHIP1 TLR9
28 cholestasis 9.9 ABCB4 F2 GGT1
29 cyclosporiasis 9.9 GGT1 GGT2
30 algoneurodystrophy 9.9 GGT1 GGT2
31 periampullary adenoma 9.9 GGT1 GGT2
32 pancreatic cystadenocarcinoma 9.9 GGT1 GGT2
33 ethmoid sinus cancer 9.9 GGT1 GGT2
34 ethmoid sinus adenocarcinoma 9.9 GGT1 GGT2
35 viral hepatitis 9.9 ALB F2 GGT1 SEPSECS TLR9
36 cholangitis 9.8 ABCB4 ALB DLAT F2 GGT1 SP100
37 liver disease 9.7 ABCB4 ALB DLAT F2 GGT1 SEPSECS
38 cholangitis, primary sclerosing 9.7 ABCB4 ALB DLAT GGT1 NUP210 SEPSECS
39 hepatic tuberculosis 9.7 ALB F2 GGT1 GGT2
40 colloid carcinoma of the pancreas 9.7 GGT1 GGT2
41 gastrointestinal system disease 9.6 ALB F2 GGT1 GGT2 TLR9
42 bile duct disease 9.6 ABCB4 ALB F2 GGT1 GGT2
43 biliary tract disease 9.6 ABCB4 ALB F2 GGT1 GGT2
44 primary biliary cirrhosis 8.6 ABCB4 ALB CENPB DBT DLAT F2

Graphical network of the top 20 diseases related to Autoimmune Disease of Urogenital Tract:



Diseases related to Autoimmune Disease of Urogenital Tract

Symptoms & Phenotypes for Autoimmune Disease of Urogenital Tract

MGI Mouse Phenotypes related to Autoimmune Disease of Urogenital Tract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 ABCB4 ALB F2 LBR SCHIP1 SLC4A2

Drugs & Therapeutics for Autoimmune Disease of Urogenital Tract

Search Clinical Trials , NIH Clinical Center for Autoimmune Disease of Urogenital Tract

Genetic Tests for Autoimmune Disease of Urogenital Tract

Anatomical Context for Autoimmune Disease of Urogenital Tract

MalaCards organs/tissues related to Autoimmune Disease of Urogenital Tract:

41
T Cells, Liver, Pancreas

Publications for Autoimmune Disease of Urogenital Tract

Variations for Autoimmune Disease of Urogenital Tract

Expression for Autoimmune Disease of Urogenital Tract

Search GEO for disease gene expression data for Autoimmune Disease of Urogenital Tract.

Pathways for Autoimmune Disease of Urogenital Tract

GO Terms for Autoimmune Disease of Urogenital Tract

Cellular components related to Autoimmune Disease of Urogenital Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 9.46 DBT DLAT OGDH PDHX
2 nuclear body GO:0016604 9.26 CENPB SCHIP1 SP100 SP140
3 pyruvate dehydrogenase complex GO:0045254 8.62 DLAT PDHX

Biological processes related to Autoimmune Disease of Urogenital Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamate metabolic process GO:0006536 9.4 GGT1 GGT2
2 zymogen activation GO:0031638 9.37 GGT1 GGT2
3 glutathione catabolic process GO:0006751 9.32 GGT1 GGT2
4 leukotriene D4 biosynthetic process GO:1901750 9.26 GGT1 GGT2
5 cysteine biosynthetic process GO:0019344 9.16 GGT1 GGT2
6 regulation of immune system process GO:0002682 8.96 GGT1 GGT2
7 peptide modification GO:0031179 8.62 GGT1 GGT2

Molecular functions related to Autoimmune Disease of Urogenital Tract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 9.32 GGT1 GGT2
2 chromo shadow domain binding GO:0070087 9.26 LBR SP100
3 transferase activity, transferring acyl groups GO:0016746 9.26 DBT DLAT GGT1 PDHX
4 pyruvate dehydrogenase (NAD+) activity GO:0034604 9.16 DLAT PDHX
5 peptidyltransferase activity GO:0000048 8.62 GGT1 GGT2

Sources for Autoimmune Disease of Urogenital Tract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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